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Conserved domains on  [gi|302564804|ref|NP_001181084|]
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ankyrin repeat and SOCS box protein 11 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-261 6.56e-36

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.46  E-value: 6.56e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  43 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGS 122
Cdd:COG0666   53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 123 AACVNVLLEFGAK--AQFEvHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGAS 200
Cdd:COG0666  133 LEIVKLLLEAGADvnAQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 302564804 201 VDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 261
Cdd:COG0666  212 VNAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 261-302 7.07e-19

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239698  Cd Length: 42  Bit Score: 78.29  E-value: 7.07e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 302564804 261 EGPPALSQLCRLCVRKCLGRACHQAIHKLRLPEPLERFLLYQ 302
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-261 6.56e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.46  E-value: 6.56e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  43 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGS 122
Cdd:COG0666   53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 123 AACVNVLLEFGAK--AQFEvHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGAS 200
Cdd:COG0666  133 LEIVKLLLEAGADvnAQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 302564804 201 VDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 261
Cdd:COG0666  212 VNAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 261-302 7.07e-19

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 78.29  E-value: 7.07e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 302564804 261 EGPPALSQLCRLCVRKCLGRACHQAIHKLRLPEPLERFLLYQ 302
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 41-263 1.03e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 79.71  E-value: 1.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  41 CWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVA-----CAKALLENGAHVNGVTVHGATPLF 115
Cdd:PHA03100  32 YKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAPDNNGITPLL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 116 NA--CCSGSAACVNVLLEFGAKaqFEVHLA---SPIHEAVKRGHR--ECMEILLANNVNIDhevpqlgtplyvACTyqRV 188
Cdd:PHA03100 112 YAisKKSNSYSIVEYLLDNGAN--VNIKNSdgeNLLHLYLESNKIdlKILKLLIDKGVDIN------------AKN--RV 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 189 DCvkkLLELGASVD----HGqwlDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREGP 263
Cdd:PHA03100 176 NY---LLSYGVPINikdvYG---FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEiFKLLLNNGP 249
Ank_2 pfam12796
Ankyrin repeats (3 copies);
81-169 5.01e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.37  E-value: 5.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804   81 LHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFgAKAQFEVHLASPIHEAVKRGHRECMEI 160
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79


                  ....*....
gi 302564804  161 LLANNVNID 169
Cdd:pfam12796  80 LLEKGADIN 88
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 262-300 3.63e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 54.09  E-value: 3.63e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 302564804  262 GPPALSQLCRLCVRKCLGRACHQAIHKLRLPEPLERFLL 300
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 264-302 4.63e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 42.78  E-value: 4.63e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 302564804   264 PALSQLCRLCVRKCLGrachqAIHKLRLPEPLERFLLYQ 302
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 144-240 2.23e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.61  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 144 SPIHEAVKRGHRECMEILLANNvNID-HEVPQLG-TPLYVACTYQRVDCVKKLLE---------LGASVDHGQwldTPLH 212
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCP-SCDlFQRGALGeTALHVAALYDNLEAAVVLMEaapelvnepMTSDLYQGE---TALH 94

                         90       100
                 ....*....|....*....|....*...
gi 302564804 213 AAARQSNVEVIHLLTDYGANLKRRNAQG 240
Cdd:cd22192   95 IAVVNQNLNLVRELIARGADVVSPRATG 122
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 208-233 3.50e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 3.50e-03
                           10        20
                   ....*....|....*....|....*.
gi 302564804   208 DTPLHAAARQSNVEVIHLLTDYGANL 233
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADI 28
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-261 6.56e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.46  E-value: 6.56e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  43 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGS 122
Cdd:COG0666   53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 123 AACVNVLLEFGAK--AQFEvHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGAS 200
Cdd:COG0666  133 LEIVKLLLEAGADvnAQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 302564804 201 VDH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 261
Cdd:COG0666  212 VNAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-261 6.76e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 122.76  E-value: 6.76e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  43 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGS 122
Cdd:COG0666   20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 123 AACVNVLLEFGAK-AQFEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASV 201
Cdd:COG0666  100 LEIVKLLLEAGADvNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV 179

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 302564804 202 DH-GQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 261
Cdd:COG0666  180 NArDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-199 2.85e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 105.04  E-value: 2.85e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSA 123
Cdd:COG0666  120 GETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHL 199

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 302564804 124 ACVNVLLEFGAKAQFEVHL-ASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGA 199
Cdd:COG0666  200 EIVKLLLEAGADVNAKDNDgKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALL 276
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 261-302 7.07e-19

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 78.29  E-value: 7.07e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 302564804 261 EGPPALSQLCRLCVRKCLGRACHQAIHKLRLPEPLERFLLYQ 302
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
42-179 6.71e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.23  E-value: 6.71e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  42 WADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSG 121
Cdd:COG0666  151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 302564804 122 SAACVNVLLEFGAKAQ-FEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPL 179
Cdd:COG0666  231 NLEIVKLLLEAGADLNaKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 41-263 1.03e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 79.71  E-value: 1.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  41 CWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVA-----CAKALLENGAHVNGVTVHGATPLF 115
Cdd:PHA03100  32 YKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAPDNNGITPLL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 116 NA--CCSGSAACVNVLLEFGAKaqFEVHLA---SPIHEAVKRGHR--ECMEILLANNVNIDhevpqlgtplyvACTyqRV 188
Cdd:PHA03100 112 YAisKKSNSYSIVEYLLDNGAN--VNIKNSdgeNLLHLYLESNKIdlKILKLLIDKGVDIN------------AKN--RV 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 189 DCvkkLLELGASVD----HGqwlDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVE-QALLLREGP 263
Cdd:PHA03100 176 NY---LLSYGVPINikdvYG---FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEiFKLLLNNGP 249
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 45-247 9.84e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 77.41  E-value: 9.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN------------------------- 99
Cdd:PHA02876 179 ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNrsninkndlsllkairnedletsll 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 100 ----GAHVNGVTVHGATPLFNACCSGS-AACVNVLLEFGAKAQFE-VHLASPIHEAVKRGH-RECMEILLANNVNIDHEV 172
Cdd:PHA02876 259 lydaGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKnIKGETPLYLMAKNGYdTENIRTLIMLGADVNAAD 338

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 302564804 173 PQLGTPLYVACTYQRV-DCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLA 247
Cdd:PHA02876 339 RLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDkTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFA 415
Ank_2 pfam12796
Ankyrin repeats (3 copies);
81-169 5.01e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.37  E-value: 5.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804   81 LHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFgAKAQFEVHLASPIHEAVKRGHRECMEI 160
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79


                  ....*....
gi 302564804  161 LLANNVNID 169
Cdd:pfam12796  80 LLEKGADIN 88
Ank_2 pfam12796
Ankyrin repeats (3 copies);
146-237 5.38e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 5.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  146 IHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLElGASVDHGQWLDTPLHAAARQSNVEVIHL 225
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 302564804  226 LTDYGANLKRRN 237
Cdd:pfam12796  80 LLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
48-135 1.12e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.22  E-value: 1.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804   48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENgAHVNgVTVHGATPLFNACCSGSAACVN 127
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVN-LKDNGRTALHYAARSGHLEIVK 78


                  ....*...
gi 302564804  128 VLLEFGAK 135
Cdd:pfam12796  79 LLLEKGAD 86
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 261-302 5.25e-14

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 64.82  E-value: 5.25e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 302564804 261 EGPPALSQLCRLCVRKCLGRACHQAIHKLRLPEPLERFLLYQ 302
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 60-247 6.41e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 71.53  E-value: 6.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  60 LKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQF- 138
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVk 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 139 EVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRvdCVKKLLELGASVDHgQWLD--TPLHAAAR 216
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR--SAIELLINNASIND-QDIDgsTPLHHAIN 263

                        170       180       190
                 ....*....|....*....|....*....|..
gi 302564804 217 -QSNVEVIHLLTDYGANLKRRNAQGKSALDLA 247
Cdd:PHA02874 264 pPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 94-252 1.70e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 67.60  E-value: 1.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  94 KALLENGAHVNGVTVH-GATPLFNACCSGSAACVNVLLEFGAKAQF-EVHLASPIHEAVKRGHRECMEILLANNVNIDHE 171
Cdd:PHA02878 151 KLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIpDKTNNSPLHHAVKHYNKPIVHILLENGASTDAR 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 172 VPQLGTPLYVACTY-QRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSnvEVIHLLTDYGANLKRRNAQGKSALDLAA 248
Cdd:PHA02878 231 DKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYILglTALHSSIKSE--RKLKLLLEYGADINSLNSYKLTPLSSAV 308


                 ....
gi 302564804 249 PKSS 252
Cdd:PHA02878 309 KQYL 312
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 80-254 8.60e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 65.01  E-value: 8.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  80 SLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQFEV-HLASPIHEAVKRGHRECM 158
Cdd:PHA02875   5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYpDIESELHDAVEEGDVKAV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 159 EILLANNVNIDHEVPQLG-TPLYVACTYQRVDCVKKLLELGASVDHGQwLD--TPLHAAARQSNVEVIHLLTDYGANLKR 235
Cdd:PHA02875  85 EELLDLGKFADDVFYKDGmTPLHLATILKKLDIMKLLIARGADPDIPN-TDkfSPLHLAVMMGDIKGIELLIDHKACLDI 163

                        170
                 ....*....|....*....
gi 302564804 236 RNAQGKSALDLAAPKSSVE 254
Cdd:PHA02875 164 EDCCGCTPLIIAMAKGDIA 182
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 263-302 1.13e-11

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 58.64  E-value: 1.13e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 302564804 263 PPALSQLCRLCVRKCLGRACHQAIHKLRLPEPLERFLLYQ 302
Cdd:cd03587    2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 46-258 1.55e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 64.70  E-value: 1.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  46 SPLHEAAAQGRLLAL-KTLIAQGVNVNLVTINRVSSLHEACLGGH-VACAKALLENGAHVNGVTVHGATPLFNACC-SGS 122
Cdd:PHA02876 275 TPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRN 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 123 AACVNVLLEFGAKAQF-EVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVA-CTYQRVDCVKKLLELGAS 200
Cdd:PHA02876 355 KDIVITLLELGANVNArDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGAN 434

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 201 VD-HGQWLDTPLHAAARQS-NVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALL 258
Cdd:PHA02876 435 VNsKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIALEYHGIVNILL 494
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 262-300 3.63e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 54.09  E-value: 3.63e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 302564804  262 GPPALSQLCRLCVRKCLGRACHQAIHKLRLPEPLERFLL 300
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 48-195 6.05e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 59.59  E-value: 6.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVN 127
Cdd:PHA02874 128 LHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIK 207

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 128 VLLEFGAKAQFEVHLA-SPIHEAVKRgHRECMEiLLANNVNIDHEVPQLGTPLYVACTYQ-RVDCVKKLL 195
Cdd:PHA02874 208 LLIDHGNHIMNKCKNGfTPLHNAIIH-NRSAIE-LLINNASINDQDIDGSTPLHHAINPPcDIDIIDILL 275
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 46-232 7.04e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 59.23  E-value: 7.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVH-GATPLFNACCSGSAA 124
Cdd:PHA02875  37 SPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKdGMTPLHLATILKKLD 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 125 CVNVLLEFGAKAQF-EVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH 203
Cdd:PHA02875 117 IMKLLIARGADPDIpNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDY 196

                        170       180       190
                 ....*....|....*....|....*....|.
gi 302564804 204 -GQWLDTPLHAAARQSN-VEVIHLLTDYGAN 232
Cdd:PHA02875 197 fGKNGCVAALCYAIENNkIDIVRLFIKRGAD 227
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 51-203 2.31e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 58.34  E-value: 2.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  51 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLL 130
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 302564804 131 EFGAKAqfEVHLASPIH-EAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDH 203
Cdd:PLN03192 612 HFASIS--DPHAAGDLLcTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDK 683
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 46-175 8.64e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 56.21  E-value: 8.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  46 SPLHEAAAQGR--LLALKTLIAQGVNVNLvtINRVsslheaclgghvacaKALLENGAHVNGVTVHGATPLFNACCSGSA 123
Cdd:PHA03100 143 NLLHLYLESNKidLKILKLLIDKGVDINA--KNRV---------------NYLLSYGVPINIKDVYGFTPLHYAVYNNNP 205

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 302564804 124 ACVNVLLEFGA----KAQFEVhlaSPIHEAVKRGHRECMEILLANNVNIDHEVPQL 175
Cdd:PHA03100 206 EFVKYLLDLGAnpnlVNKYGD---TPLHIAILNNNKEIFKLLLNNGPSIKTIIETL 258
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 55-248 1.00e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 55.74  E-value: 1.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  55 GRLLALKTLIAQGVN-VNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFG 133
Cdd:PHA02874  12 GDIEAIEKIIKNKGNcINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 134 AKAQFevhLASPIHEavkrghRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASV----DHGQWldt 209
Cdd:PHA02874  92 VDTSI---LPIPCIE------KDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVniedDNGCY--- 159

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 302564804 210 PLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAA 248
Cdd:PHA02874 160 PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAA 198
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 114-259 1.00e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 55.77  E-value: 1.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 114 LFNACCSGSAACVNVLLEFGAKAQFEVHLA-SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVK 192
Cdd:PHA02875   6 LCDAILFGELDIARRLLDIGINPNFEIYDGiSPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 302564804 193 KLLELGASVDHGQWLD--TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
Cdd:PHA02875  86 ELLDLGKFADDVFYKDgmTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELL 154
PHA03095 PHA03095
ankyrin-like protein; Provisional
 50-245 3.04e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 54.26  E-value: 3.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  50 EAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAK---ALLENGAHVNGVTVHGATPLFNACCSGS-AAC 125
Cdd:PHA03095  20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDivrLLLEAGADVNAPERCGFTPLHLYLYNATtLDV 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 126 VNVLLEFGAkaqfevhlaspiheavkrghrecmeillanNVNIDHEVPQlgTPLYVACTYQRVD--CVKKLLELGASV-- 201
Cdd:PHA03095 100 IKLLIKAGA------------------------------DVNAKDKVGR--TPLHVYLSGFNINpkVIRLLLRKGADVna 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 302564804 202 --DHGQwldTPLHAAARQSN--VEVIHLLTDYGANLKRRNAQGKSALD 245
Cdd:PHA03095 148 ldLYGM---TPLAVLLKSRNanVELLRLLIDAGADVYAVDDRFRSLLH 192
PHA03095 PHA03095
ankyrin-like protein; Provisional
 44-248 1.13e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 52.72  E-value: 1.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  44 DRSPLH---EAAAQGRLLALKTLIAQGVNVNLVTINRVSSLH-EACLGGHVACAKALLENGAHVNGVTVHGATPLfNACC 119
Cdd:PHA03095  47 GKTPLHlylHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPL-HVYL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 120 SG---SAACVNVLLEFGAKAQ-FEVHLASPIHEAVKRgHRECMEIL--LANNVNIDHEVPQLG-TPLYVACTY--QRVDC 190
Cdd:PHA03095 126 SGfniNPKVIRLLLRKGADVNaLDLYGMTPLAVLLKS-RNANVELLrlLIDAGADVYAVDDRFrSLLHHHLQSfkPRARI 204

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 302564804 191 VKKLLELGASVDHGQWLD-TPLHAAARQSNVEVIHL--LTDYGANLKRRNAQGKSALDLAA 248
Cdd:PHA03095 205 VRELIRAGCDPAATDMLGnTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAA 265
Ank_4 pfam13637
Ankyrin repeats (many copies);
45-97 2.70e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.50  E-value: 2.70e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 302564804   45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALL 97
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 44-195 5.79e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 50.65  E-value: 5.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNAccsgSA 123
Cdd:PHA02878 168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIS----VG 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 124 ACVN-----VLLEFGA--KAQFEVHLASPIHEAVKRGHRecMEILL-----ANNVNIDHEvpqlgTPLYVAC-TYQRVDC 190
Cdd:PHA02878 244 YCKDydilkLLLEHGVdvNAKSYILGLTALHSSIKSERK--LKLLLeygadINSLNSYKL-----TPLSSAVkQYLCINI 316


                 ....*
gi 302564804 191 VKKLL 195
Cdd:PHA02878 317 GRILI 321
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 263-302 6.23e-07

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 45.25  E-value: 6.23e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 302564804 263 PPALSQLCRLCVRKCLGRACHQAIHKLRLPEPLERFLLYQ 302
Cdd:cd03724    3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQYR 42
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 263-302 7.96e-07

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 44.99  E-value: 7.96e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 302564804 263 PPALSQLCRLCVRKCLGRACHQAIHKLRLPEPLERFLLYQ 302
Cdd:cd03718    3 PLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLYQ 42
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 46-212 8.20e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.45  E-value: 8.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  46 SPLHEAAAQGRLL-ALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPL-FNACCSGSA 123
Cdd:PHA02876 343 TPLHQASTLDRNKdIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALhFALCGTNPY 422

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 124 ACVNVLLEFGAKAQFE-VHLASPIHEAVKRGHR-ECMEILLANNVNIDHEVPQLGTPLYVACTYQRVdcVKKLLELGASV 201
Cdd:PHA02876 423 MSVKTLIDRGANVNSKnKDLSTPLHYACKKNCKlDVIEMLLDNGADVNAINIQNQYPLLIALEYHGI--VNILLHYGAEL 500

                        170
                 ....*....|.
gi 302564804 202 DHGQWLDTPLH 212
Cdd:PHA02876 501 RDSRVLHKSLN 511
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 112-261 9.13e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.96  E-value: 9.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 112 TPLFNACCSGSAACVNVLLEFGAKA-QFEVHLASPIHEAVKRGHRECMEILLANNVNIdhevpqlgTPLYVACTYQrvDC 190
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADInHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDT--------SILPIPCIEK--DM 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 302564804 191 VKKLLELGASVD-HGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE 261
Cdd:PHA02874 107 IKTILDCGIDVNiKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLE 178
Ank_2 pfam12796
Ankyrin repeats (3 copies);
45-104 1.18e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.88  E-value: 1.18e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804   45 RSPLHEAAAQGRLLALKTLIAQgVNVNLVTINRvSSLHEACLGGHVACAKALLENGAHVN 104
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVKLLLEKGADIN 88
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 47-193 1.37e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.19  E-value: 1.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  47 PLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAAcV 126
Cdd:PHA02874 160 PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSA-I 238

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 302564804 127 NVLLEFGAKAQFEVHLASPIHEAVKRG-HRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKK 193
Cdd:PHA02874 239 ELLINNASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDPVIK 306
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 93-162 1.61e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.51  E-value: 1.61e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 302564804  93 AKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQ-FEVHLASPIHEAVKRGHRECMEILL 162
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTlLDKDGKTPLELAEENGFREVVQLLS 168
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 264-302 4.63e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 42.78  E-value: 4.63e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 302564804   264 PALSQLCRLCVRKCLGrachqAIHKLRLPEPLERFLLYQ 302
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 261-302 1.13e-05

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 41.77  E-value: 1.13e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 302564804 261 EGPPALSQLCRLCVRKCLGRACHQAIHKLRLPEPLERFLLYQ 302
Cdd:cd03721    1 EPPRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQ 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
177-226 3.16e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 3.16e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 302564804  177 TPLYVACTYQRVDCVKKLLELGASVDH--GQWlDTPLHAAARQSNVEVIHLL 226
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAvdGNG-ETALHFAASNGNVEVLKLL 53
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 263-302 3.36e-05

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 40.48  E-value: 3.36e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 302564804 263 PPALSQLCRLCVRKCLGRACHQAIHKLRLPEPLERFLLYQ 302
Cdd:cd03720    3 PRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 81-262 3.74e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.87  E-value: 3.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  81 LHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNAC-----------------CSGS--------------------- 122
Cdd:PHA02878  41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICkepnklgmkemirsinkCSVFytlvaikdafnnrnveifkii 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 123 --------------------------AACVNVLLEFGA--KAQFEVHLASPIHEAVKRGHRECMEILLANNVNIDheVPQ 174
Cdd:PHA02878 121 ltnrykniqtidlvyidkkskddiieAEITKLLLSYGAdiNMKDRHKGNTALHYATENKDQRLTELLLSYGANVN--IPD 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 175 LG--TPLYVACTYQRVDCVKKLLELGASVDH-GQWLDTPLH-AAARQSNVEVIHLLTDYGANLkrrNAQ----GKSALDL 246
Cdd:PHA02878 199 KTnnSPLHHAVKHYNKPIVHILLENGASTDArDKCGNTPLHiSVGYCKDYDILKLLLEHGVDV---NAKsyilGLTALHS 275

                        250
                 ....*....|....*.
gi 302564804 247 AApKSSVEQALLLREG 262
Cdd:PHA02878 276 SI-KSERKLKLLLEYG 290
Ank_4 pfam13637
Ankyrin repeats (many copies);
77-130 4.08e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 4.08e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 302564804   77 RVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLL 130
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 263-300 4.65e-05

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 40.12  E-value: 4.65e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 302564804 263 PPALSQLCRLCVRKCLGRACHQAIHKLRLPEPLERFLL 300
Cdd:cd03723    3 PRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLL 40
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 263-302 4.99e-05

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 39.96  E-value: 4.99e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 302564804 263 PPALSQLCRLCVRKCLGRACHQAIHKLRLPEPLERFLLYQ 302
Cdd:cd03744    3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLYQ 42
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 99-259 5.94e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.47  E-value: 5.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  99 NGAHVNGVTvhgATPLFNACCSGSAACVNVLLEFGAKAQF-EVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGT 177
Cdd:PLN03192 517 GGEHDDPNM---ASNLLTVASTGNAALLEELLKAKLDPDIgDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNT 593

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 178 PLY--VACTYQRVdcvKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQ 255
Cdd:PLN03192 594 ALWnaISAKHHKI---FRILYHFASISDPHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDM 670


                 ....
gi 302564804 256 ALLL 259
Cdd:PLN03192 671 VRLL 674
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 48-136 9.14e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.73  E-value: 9.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804  48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVN 127
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                         90
                 ....*....|....*.
gi 302564804 128 VLL-------EFGAKA 136
Cdd:PTZ00322 166 LLSrhsqchfELGANA 181
Ank_4 pfam13637
Ankyrin repeats (many copies);
209-259 9.89e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 9.89e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 302564804  209 TPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLL 259
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 263-301 1.05e-04

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 39.00  E-value: 1.05e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 302564804 263 PPALSQLCRLCVRKCLGRACHQAIHKLRLPEPLERFLLY 301
Cdd:cd03729    3 PLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSY 41
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 263-302 3.56e-04

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 37.63  E-value: 3.56e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 302564804 263 PPALSQLCRLCVRKCLGRACHQAIHKLRLPEPLERFLLYQ 302
Cdd:cd03743    3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 261-302 4.40e-04

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 37.31  E-value: 4.40e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 302564804 261 EGPPALSQLCRLCVRKCLGRACHQAIHKLRLPEPLERFLLYQ 302
Cdd:cd03719    1 AEPHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYLLYQ 42
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 46-117 4.59e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.49  E-value: 4.59e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 302564804  46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLggHVACAKALLENGAHVNGVTVHGATPLFNA 117
Cdd:PHA02874 192 SPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPLHHA 261
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 177-252 8.87e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.65  E-value: 8.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 177 TPLYVACTYQRVDCVKKLLELGASVdhgQWLD----TPLHAAARQSNVEVIHLLT-------DYGANLKRRNAQGKSALD 245
Cdd:PTZ00322 117 TPLHIACANGHVQVVRVLLEFGADP---TLLDkdgkTPLELAEENGFREVVQLLSrhsqchfELGANAKPDSFTGKPPSL 193


                 ....*..
gi 302564804 246 LAAPKSS 252
Cdd:PTZ00322 194 EDSPISS 200
Ank_4 pfam13637
Ankyrin repeats (many copies);
144-195 8.98e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 8.98e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 302564804  144 SPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLL 195
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 257-301 1.13e-03

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 36.12  E-value: 1.13e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 302564804   257 LLLREGPPALSQLCRLCVRKCLGRachQAIHKLRLPEPLERFLLY 301
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRT---DQIKTLPLPPKLKDYLSY 42
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 261-302 1.32e-03

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 36.36  E-value: 1.32e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 302564804 261 EGPPALSQLCRLCVRKCLGR---ACHQAIHKLRLPEPLERFLLYQ 302
Cdd:cd03730    1 TNPRSLKHLCRLKIRACMGRlrlRCPVFMSFLPLPNRLKAYILYK 45
Ank_5 pfam13857
Ankyrin repeats (many copies);
63-114 1.68e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.17  E-value: 1.68e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 302564804   63 LIAQG-VNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPL 114
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 144-240 2.23e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.61  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564804 144 SPIHEAVKRGHRECMEILLANNvNID-HEVPQLG-TPLYVACTYQRVDCVKKLLE---------LGASVDHGQwldTPLH 212
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCP-SCDlFQRGALGeTALHVAALYDNLEAAVVLMEaapelvnepMTSDLYQGE---TALH 94

                         90       100
                 ....*....|....*....|....*...
gi 302564804 213 AAARQSNVEVIHLLTDYGANLKRRNAQG 240
Cdd:cd22192   95 IAVVNQNLNLVRELIARGADVVSPRATG 122
Ank_5 pfam13857
Ankyrin repeats (many copies);
205-247 3.42e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.01  E-value: 3.42e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 302564804  205 QWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLA 247
Cdd:pfam13857  14 GEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 208-233 3.50e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 3.50e-03
                           10        20
                   ....*....|....*....|....*.
gi 302564804   208 DTPLHAAARQSNVEVIHLLTDYGANL 233
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADI 28
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 261-302 3.80e-03

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 34.49  E-value: 3.80e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 302564804 261 EGPPALSQLCRLCVRKCLGRachQAIHKLRLPEPLERFLLYQ 302
Cdd:cd03717    1 TSVRSLQHLCRFVIRQCTRR---DLIDQLPLPRRLKDYLKEY 39
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 48-109 7.55e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 37.93  E-value: 7.55e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 302564804  48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVH 109
Cdd:PLN03192 626 LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 261-302 8.94e-03

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 34.04  E-value: 8.94e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 302564804 261 EGPPALSQLCRLCVRKCLG--RACHQA-IHKLRLPEPLERFLLYQ 302
Cdd:cd03731    1 ENPRPLKHLCRLKIRKLMGlqKLQQPSsMKKLPLPPALKRYILYK 45
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 177-202 9.26e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 9.26e-03
                           10        20
                   ....*....|....*....|....*.
gi 302564804   177 TPLYVACTYQRVDCVKKLLELGASVD 202
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 144-169 9.92e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 9.92e-03
                           10        20
                   ....*....|....*....|....*.
gi 302564804   144 SPIHEAVKRGHRECMEILLANNVNID 169
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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