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Conserved domains on  [gi|1783383632|ref|NP_001181022|]
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WD repeat and coiled-coil-containing protein [Macaca mulatta]

Protein Classification

WDCP domain-containing protein( domain architecture ID 10634116)

WDCP domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WDCP pfam15390
WD repeat and coiled-coil-containing protein family; This family includes WD repeat and ...
2-672 0e+00

WD repeat and coiled-coil-containing protein family; This family includes WD repeat and coiled-coil-containing protein (WDCP, previously known as C2orf44), which is found in eukaryotes and consists of around 721 amino acids. The N-terminal contains two WD (tryptophan-aspartic acid) repeats (WD1 and WD2). WD repeats may be involved in a range of biological functions including apoptosis, transcriptional regulation and signal transduction. The C-terminal contains a proline-rich sequence (PPRLPQR), and is predicted to have leucine-rich coiled coil region (CC). WDCP was identified in a proteomic screen to find signalling components that interact with Hck (hematopoietic cell kinase), a non-receptor tyrosine kinase. WDCP was shown to bind tightly and specifically to the SH3 domain of Hck in U937 human monocytic cells. WDCP was also shown to exist as an oligomer when expressed in mammalian cells. While the function of WDCP is unknown, it has been identified in a gene fusion event with anaplastic lymphoma kinase (ALK) in colorectal cancer patients.


:

Pssm-ID: 464697  Cd Length: 688  Bit Score: 1276.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632   2 ELGKGKLLRTGLNALHQAVHLIHGLAWTDGNQVVLTNLQLHNGEVKFGDSKVIGQFECVCGLSWAPPVADDTPVLLAVQQ 81
Cdd:pfam15390   1 ELGKGKLLRTGLNALYQAIHPVHGLAWTDGKQVVLTDLQLHNGEPKFGDSNVIGQFEHVHGLSWAPPGTADTPALLAVQH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632  82 EKRVTVWQLCPSPTESSRWLTSQTCEIRGSLPILPQGCVWHPKCAILTVLTAQDVSIFPNVHSDNSQVKADINTQDRIHC 161
Cdd:pfam15390  81 KKHVTVWQLCPSTTETSKLLVSQTCEIREPFPVLPQGCVWHPKKAILTVLTARDVSVLHSVHCDSSRVKADIKGSGLIHC 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632 162 ACWTQDGLRLVVAVGSSLHSYIWDSAQKTLHRCSSCLVFDVDSHVCSITATVDSQVAIATELPLDKICGLNASETFNVPP 241
Cdd:pfam15390 161 ACWTKDGQRLVVAVGSALHSYIWDSAQKTLHRCSFCPVFDVGSYICSIEATVDSQVAVATELPLDKICGLNAGEAFDVPP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632 242 NSKDTTLYALPVIGEVPSIDKEATDSEKDSEVSV-SSSYLEPLDLTHIHFSQHKSEGNSLICLRKKDYLTGTGQDSSHLV 320
Cdd:pfam15390 241 SGEDTSQSTLPVSDEEPSVDKGASSSDSESSTSVvSSSSSDPLDLTHILANRRRSDPSPLICLRKKDYLTGTGQDSSHLV 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632 321 LVTFKKAVTMTRKVTIPGILVPDLIAFNLKAHVVAVASNTCNIILIYSLIPSSVPNIQQIRLENTERPKGICFLTDKLLL 400
Cdd:pfam15390 321 LVTFEKKVTTTRKVSIPGILVPDLIAFDPKAQVVAVASNTCNIILVYSVTPSSMPNIQQIQLEKNERPKGICFLTDKLLL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632 401 ILVGKQKLTDTTFLPSSKSDQYAISLIVREVMLEEEPSITSSESHTTYSTFSAPLNKANRKKLIESLSPDFCHQNKGLLL 480
Cdd:pfam15390 401 ILVGKQKSTDPAFLPSSKSDKYIIRLMVKELMLEEESSVTSSESQSSYSTFSSLLNKANRKKLIESLSPDFCPQNRGLLL 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632 481 TANTSSQTGRPGRTLIKEI----QSPLSSICD---------DSIAL---DAEPVTQPASLPRHSSTPDHTSTLEPPHLPQ 544
Cdd:pfam15390 481 PGNTSIQSPRPGRTLIEEIksleQSPPSSVCDlseralssnSSIALetlDAEPVNRSATLPSPSSTPDSSSTPESPNLPQ 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632 545 RKSLQSEKETYKLSKEVEILSRNLVEMQRCFSELTNCLHNGRKSSSVYPLSQDLPYVHIIYQKPYYLGPVVEKRAVLLCD 624
Cdd:pfam15390 561 NNNLSKEKETEQLSKELERLSRNFTEVQQCLSELTDFLQNGKKSSPVYPLSQDPPYVHITYQKPYSVGPVVEKRAVLLCD 640
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*...
gi 1783383632 625 GKLRLSTVQQTFGLSLIEMLHDCHWILLTADNEGFIPLTFTATQEIII 672
Cdd:pfam15390 641 GKLRLSTVQQLFGLSLVEMLHGSHWILLTADSEGFIPLTFTATQEIII 688
 
Name Accession Description Interval E-value
WDCP pfam15390
WD repeat and coiled-coil-containing protein family; This family includes WD repeat and ...
2-672 0e+00

WD repeat and coiled-coil-containing protein family; This family includes WD repeat and coiled-coil-containing protein (WDCP, previously known as C2orf44), which is found in eukaryotes and consists of around 721 amino acids. The N-terminal contains two WD (tryptophan-aspartic acid) repeats (WD1 and WD2). WD repeats may be involved in a range of biological functions including apoptosis, transcriptional regulation and signal transduction. The C-terminal contains a proline-rich sequence (PPRLPQR), and is predicted to have leucine-rich coiled coil region (CC). WDCP was identified in a proteomic screen to find signalling components that interact with Hck (hematopoietic cell kinase), a non-receptor tyrosine kinase. WDCP was shown to bind tightly and specifically to the SH3 domain of Hck in U937 human monocytic cells. WDCP was also shown to exist as an oligomer when expressed in mammalian cells. While the function of WDCP is unknown, it has been identified in a gene fusion event with anaplastic lymphoma kinase (ALK) in colorectal cancer patients.


Pssm-ID: 464697  Cd Length: 688  Bit Score: 1276.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632   2 ELGKGKLLRTGLNALHQAVHLIHGLAWTDGNQVVLTNLQLHNGEVKFGDSKVIGQFECVCGLSWAPPVADDTPVLLAVQQ 81
Cdd:pfam15390   1 ELGKGKLLRTGLNALYQAIHPVHGLAWTDGKQVVLTDLQLHNGEPKFGDSNVIGQFEHVHGLSWAPPGTADTPALLAVQH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632  82 EKRVTVWQLCPSPTESSRWLTSQTCEIRGSLPILPQGCVWHPKCAILTVLTAQDVSIFPNVHSDNSQVKADINTQDRIHC 161
Cdd:pfam15390  81 KKHVTVWQLCPSTTETSKLLVSQTCEIREPFPVLPQGCVWHPKKAILTVLTARDVSVLHSVHCDSSRVKADIKGSGLIHC 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632 162 ACWTQDGLRLVVAVGSSLHSYIWDSAQKTLHRCSSCLVFDVDSHVCSITATVDSQVAIATELPLDKICGLNASETFNVPP 241
Cdd:pfam15390 161 ACWTKDGQRLVVAVGSALHSYIWDSAQKTLHRCSFCPVFDVGSYICSIEATVDSQVAVATELPLDKICGLNAGEAFDVPP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632 242 NSKDTTLYALPVIGEVPSIDKEATDSEKDSEVSV-SSSYLEPLDLTHIHFSQHKSEGNSLICLRKKDYLTGTGQDSSHLV 320
Cdd:pfam15390 241 SGEDTSQSTLPVSDEEPSVDKGASSSDSESSTSVvSSSSSDPLDLTHILANRRRSDPSPLICLRKKDYLTGTGQDSSHLV 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632 321 LVTFKKAVTMTRKVTIPGILVPDLIAFNLKAHVVAVASNTCNIILIYSLIPSSVPNIQQIRLENTERPKGICFLTDKLLL 400
Cdd:pfam15390 321 LVTFEKKVTTTRKVSIPGILVPDLIAFDPKAQVVAVASNTCNIILVYSVTPSSMPNIQQIQLEKNERPKGICFLTDKLLL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632 401 ILVGKQKLTDTTFLPSSKSDQYAISLIVREVMLEEEPSITSSESHTTYSTFSAPLNKANRKKLIESLSPDFCHQNKGLLL 480
Cdd:pfam15390 401 ILVGKQKSTDPAFLPSSKSDKYIIRLMVKELMLEEESSVTSSESQSSYSTFSSLLNKANRKKLIESLSPDFCPQNRGLLL 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632 481 TANTSSQTGRPGRTLIKEI----QSPLSSICD---------DSIAL---DAEPVTQPASLPRHSSTPDHTSTLEPPHLPQ 544
Cdd:pfam15390 481 PGNTSIQSPRPGRTLIEEIksleQSPPSSVCDlseralssnSSIALetlDAEPVNRSATLPSPSSTPDSSSTPESPNLPQ 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632 545 RKSLQSEKETYKLSKEVEILSRNLVEMQRCFSELTNCLHNGRKSSSVYPLSQDLPYVHIIYQKPYYLGPVVEKRAVLLCD 624
Cdd:pfam15390 561 NNNLSKEKETEQLSKELERLSRNFTEVQQCLSELTDFLQNGKKSSPVYPLSQDPPYVHITYQKPYSVGPVVEKRAVLLCD 640
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*...
gi 1783383632 625 GKLRLSTVQQTFGLSLIEMLHDCHWILLTADNEGFIPLTFTATQEIII 672
Cdd:pfam15390 641 GKLRLSTVQQLFGLSLVEMLHGSHWILLTADSEGFIPLTFTATQEIII 688
 
Name Accession Description Interval E-value
WDCP pfam15390
WD repeat and coiled-coil-containing protein family; This family includes WD repeat and ...
2-672 0e+00

WD repeat and coiled-coil-containing protein family; This family includes WD repeat and coiled-coil-containing protein (WDCP, previously known as C2orf44), which is found in eukaryotes and consists of around 721 amino acids. The N-terminal contains two WD (tryptophan-aspartic acid) repeats (WD1 and WD2). WD repeats may be involved in a range of biological functions including apoptosis, transcriptional regulation and signal transduction. The C-terminal contains a proline-rich sequence (PPRLPQR), and is predicted to have leucine-rich coiled coil region (CC). WDCP was identified in a proteomic screen to find signalling components that interact with Hck (hematopoietic cell kinase), a non-receptor tyrosine kinase. WDCP was shown to bind tightly and specifically to the SH3 domain of Hck in U937 human monocytic cells. WDCP was also shown to exist as an oligomer when expressed in mammalian cells. While the function of WDCP is unknown, it has been identified in a gene fusion event with anaplastic lymphoma kinase (ALK) in colorectal cancer patients.


Pssm-ID: 464697  Cd Length: 688  Bit Score: 1276.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632   2 ELGKGKLLRTGLNALHQAVHLIHGLAWTDGNQVVLTNLQLHNGEVKFGDSKVIGQFECVCGLSWAPPVADDTPVLLAVQQ 81
Cdd:pfam15390   1 ELGKGKLLRTGLNALYQAIHPVHGLAWTDGKQVVLTDLQLHNGEPKFGDSNVIGQFEHVHGLSWAPPGTADTPALLAVQH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632  82 EKRVTVWQLCPSPTESSRWLTSQTCEIRGSLPILPQGCVWHPKCAILTVLTAQDVSIFPNVHSDNSQVKADINTQDRIHC 161
Cdd:pfam15390  81 KKHVTVWQLCPSTTETSKLLVSQTCEIREPFPVLPQGCVWHPKKAILTVLTARDVSVLHSVHCDSSRVKADIKGSGLIHC 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632 162 ACWTQDGLRLVVAVGSSLHSYIWDSAQKTLHRCSSCLVFDVDSHVCSITATVDSQVAIATELPLDKICGLNASETFNVPP 241
Cdd:pfam15390 161 ACWTKDGQRLVVAVGSALHSYIWDSAQKTLHRCSFCPVFDVGSYICSIEATVDSQVAVATELPLDKICGLNAGEAFDVPP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632 242 NSKDTTLYALPVIGEVPSIDKEATDSEKDSEVSV-SSSYLEPLDLTHIHFSQHKSEGNSLICLRKKDYLTGTGQDSSHLV 320
Cdd:pfam15390 241 SGEDTSQSTLPVSDEEPSVDKGASSSDSESSTSVvSSSSSDPLDLTHILANRRRSDPSPLICLRKKDYLTGTGQDSSHLV 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632 321 LVTFKKAVTMTRKVTIPGILVPDLIAFNLKAHVVAVASNTCNIILIYSLIPSSVPNIQQIRLENTERPKGICFLTDKLLL 400
Cdd:pfam15390 321 LVTFEKKVTTTRKVSIPGILVPDLIAFDPKAQVVAVASNTCNIILVYSVTPSSMPNIQQIQLEKNERPKGICFLTDKLLL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632 401 ILVGKQKLTDTTFLPSSKSDQYAISLIVREVMLEEEPSITSSESHTTYSTFSAPLNKANRKKLIESLSPDFCHQNKGLLL 480
Cdd:pfam15390 401 ILVGKQKSTDPAFLPSSKSDKYIIRLMVKELMLEEESSVTSSESQSSYSTFSSLLNKANRKKLIESLSPDFCPQNRGLLL 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632 481 TANTSSQTGRPGRTLIKEI----QSPLSSICD---------DSIAL---DAEPVTQPASLPRHSSTPDHTSTLEPPHLPQ 544
Cdd:pfam15390 481 PGNTSIQSPRPGRTLIEEIksleQSPPSSVCDlseralssnSSIALetlDAEPVNRSATLPSPSSTPDSSSTPESPNLPQ 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783383632 545 RKSLQSEKETYKLSKEVEILSRNLVEMQRCFSELTNCLHNGRKSSSVYPLSQDLPYVHIIYQKPYYLGPVVEKRAVLLCD 624
Cdd:pfam15390 561 NNNLSKEKETEQLSKELERLSRNFTEVQQCLSELTDFLQNGKKSSPVYPLSQDPPYVHITYQKPYSVGPVVEKRAVLLCD 640
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*...
gi 1783383632 625 GKLRLSTVQQTFGLSLIEMLHDCHWILLTADNEGFIPLTFTATQEIII 672
Cdd:pfam15390 641 GKLRLSTVQQLFGLSLVEMLHGSHWILLTADSEGFIPLTFTATQEIII 688
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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