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Conserved domains on  [gi|302564087|ref|NP_001181013|]
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gypsy retrotransposon integrase-like protein 1 [Macaca mulatta]

Protein Classification

integrase( domain architecture ID 16054273)

integrase containing a zinc-binding domain functions in DNA integration or recombination, such as human Gypsy retrotransposon integrase-like protein 1 (GIN1)

CATH:  3.30.420.10
EC:  3.1.26.-
Gene Ontology:  GO:0003676|GO:0005524|GO:0003677|GO:0046872|GO:0015074|GO:0006310|GO:0016893
PubMed:  11774877
SCOP:  4000539

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrase_H2C2 pfam17921
Integrase zinc binding domain; This zinc binding domain is found in a wide variety of ...
 65-124 1.87e-13

Integrase zinc binding domain; This zinc binding domain is found in a wide variety of integrase proteins.


:

Pssm-ID: 465569 [Multi-domain]  Cd Length: 58  Bit Score: 64.96  E-value: 1.87e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564087   65 VSEEEKKKVLRECHenDSGAHHGISRTLTLVESNYYWTSVTNDVKQWVYACQHCQVAKNT 124
Cdd:pfam17921   1 VPKSLRKEILKEAH--DSGGHLGIEKTLARLRRRYWWPGMRKDVKKYVKSCETCQRRKPS 58
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 155-229 6.37e-05

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


:

Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 41.92  E-value: 6.37e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 302564087  155 NRSHVYAIIMTDLFTKWVVILPLCDVSASEVSKAIINIFFLY--GPPQKIIMDQRDEFIQQINIELYRLFGIKQIVI 229
Cdd:pfam00665  17 GGGKLYLLVIVDDFSREILAWALSSEMDAELVLDALERAIAFrgGVPLIIHSDNGSEYTSKAFREFLKDLGIKPSFS 93
 
Name Accession Description Interval E-value
Integrase_H2C2 pfam17921
Integrase zinc binding domain; This zinc binding domain is found in a wide variety of ...
 65-124 1.87e-13

Integrase zinc binding domain; This zinc binding domain is found in a wide variety of integrase proteins.


Pssm-ID: 465569 [Multi-domain]  Cd Length: 58  Bit Score: 64.96  E-value: 1.87e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564087   65 VSEEEKKKVLRECHenDSGAHHGISRTLTLVESNYYWTSVTNDVKQWVYACQHCQVAKNT 124
Cdd:pfam17921   1 VPKSLRKEILKEAH--DSGGHLGIEKTLARLRRRYWWPGMRKDVKKYVKSCETCQRRKPS 58
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 155-229 6.37e-05

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 41.92  E-value: 6.37e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 302564087  155 NRSHVYAIIMTDLFTKWVVILPLCDVSASEVSKAIINIFFLY--GPPQKIIMDQRDEFIQQINIELYRLFGIKQIVI 229
Cdd:pfam00665  17 GGGKLYLLVIVDDFSREILAWALSSEMDAELVLDALERAIAFrgGVPLIIHSDNGSEYTSKAFREFLKDLGIKPSFS 93
 
Name Accession Description Interval E-value
Integrase_H2C2 pfam17921
Integrase zinc binding domain; This zinc binding domain is found in a wide variety of ...
 65-124 1.87e-13

Integrase zinc binding domain; This zinc binding domain is found in a wide variety of integrase proteins.


Pssm-ID: 465569 [Multi-domain]  Cd Length: 58  Bit Score: 64.96  E-value: 1.87e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564087   65 VSEEEKKKVLRECHenDSGAHHGISRTLTLVESNYYWTSVTNDVKQWVYACQHCQVAKNT 124
Cdd:pfam17921   1 VPKSLRKEILKEAH--DSGGHLGIEKTLARLRRRYWWPGMRKDVKKYVKSCETCQRRKPS 58
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 155-229 6.37e-05

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 41.92  E-value: 6.37e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 302564087  155 NRSHVYAIIMTDLFTKWVVILPLCDVSASEVSKAIINIFFLY--GPPQKIIMDQRDEFIQQINIELYRLFGIKQIVI 229
Cdd:pfam00665  17 GGGKLYLLVIVDDFSREILAWALSSEMDAELVLDALERAIAFrgGVPLIIHSDNGSEYTSKAFREFLKDLGIKPSFS 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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