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Conserved domains on  [gi|302563645|ref|NP_001180713|]
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olfactory receptor 4F3/4F16/4F29 [Macaca mulatta]

Protein Classification

olfactory receptor family 4 protein( domain architecture ID 11607035)

olfactory receptor family 4 protein is an odorant receptor belonging to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
35-291 1.98e-161

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 450.50  E-value: 1.98e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15226   11 YVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMVL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15226   91 LIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLACTDTYV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMDKFLAIF 274
Cdd:cd15226  171 LELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTFPVDKFLAVF 250
                        250
                 ....*....|....*..
gi 302563645 275 DAVLTPFLNPVVYTFRN 291
Cdd:cd15226  251 YTVITPLLNPIIYTLRN 267
 
Name Accession Description Interval E-value
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
35-291 1.98e-161

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 450.50  E-value: 1.98e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15226   11 YVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMVL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15226   91 LIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLACTDTYV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMDKFLAIF 274
Cdd:cd15226  171 LELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTFPVDKFLAVF 250
                        250
                 ....*....|....*..
gi 302563645 275 DAVLTPFLNPVVYTFRN 291
Cdd:cd15226  251 YTVITPLLNPIIYTLRN 267
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
35-301 3.71e-37

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 133.78  E-value: 3.71e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645   35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDtyr 194
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCAD--- 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  195 lqfmVTVNS---GFICVGTFFI----LLISYIFILFTVRKHSSG-GSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQ 266
Cdd:pfam13853 162 ----IKVNNiygLFVVTSTFGIdsllIVLSYGLILRTVLGIASReGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHN 237
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 302563645  267 MDKFLAIFDA----VLTPFLNPVVYTFRNKEMKAAIKRV 301
Cdd:pfam13853 238 VPPLLQIMMAnaylFFPPVLNPIVYSVKTKQIRDCVKRM 276
 
Name Accession Description Interval E-value
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
35-291 1.98e-161

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 450.50  E-value: 1.98e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15226   11 YVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMVL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15226   91 LIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLACTDTYV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMDKFLAIF 274
Cdd:cd15226  171 LELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTFPVDKFLAVF 250
                        250
                 ....*....|....*..
gi 302563645 275 DAVLTPFLNPVVYTFRN 291
Cdd:cd15226  251 YTVITPLLNPIIYTLRN 267
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
35-291 1.58e-118

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 341.50  E-value: 1.58e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15939   11 YLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15939   91 LTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACTDTYV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMDKFLAIF 274
Cdd:cd15939  171 IGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTFPIDKVVAVF 250
                        250
                 ....*....|....*..
gi 302563645 275 DAVLTPFLNPVVYTFRN 291
Cdd:cd15939  251 YTIITPMLNPLIYTLRN 267
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
35-291 1.72e-109

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 318.66  E-value: 1.72e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd13954   11 YLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLGGTECFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd13954   91 LAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLSCSDTSL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRK-HSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPN--SQMDKFL 271
Cdd:cd13954  171 NELVIFILAGFVGLGSFLLTLVSYIYIISTILKiPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSSysSDLDKVV 250
                        250       260
                 ....*....|....*....|
gi 302563645 272 AIFDAVLTPFLNPVVYTFRN 291
Cdd:cd13954  251 SVFYTVVTPMLNPIIYSLRN 270
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
35-291 1.85e-109

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 318.51  E-value: 1.85e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15936   11 YLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEVFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15936   91 LSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACTDTFL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMDKFLAIF 274
Cdd:cd15936  171 LELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTFPMDKAVSVL 250
                        250
                 ....*....|....*..
gi 302563645 275 DAVLTPFLNPVVYTFRN 291
Cdd:cd15936  251 YTVITPMLNPMIYTLRN 267
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
35-298 5.44e-101

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 297.44  E-value: 5.44e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15225   11 YLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTECFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15225   91 LAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACADTSL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRK-HSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPN--SQMDKFL 271
Cdd:cd15225  171 NEIAIFVASVLVILVPFLLILVSYIFIISTILKiPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSysPETDKLL 250
                        250       260
                 ....*....|....*....|....*..
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15225  251 SLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
35-291 5.95e-98

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 289.34  E-value: 5.95e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15940   11 YLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15940   91 LTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACTDTYL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMDKFLAIF 274
Cdd:cd15940  171 IDILIVSNSGLISLVCFVALLGSYIVILVSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFSEDKVVSVF 250
                        250
                 ....*....|....*..
gi 302563645 275 DAVLTPFLNPVVYTFRN 291
Cdd:cd15940  251 YTVVTPLLNPIIYTLRN 267
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
35-291 1.68e-96

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 285.94  E-value: 1.68e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15230   11 YLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15230   91 LAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCSDTHI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQM--DKFL 271
Cdd:cd15230  171 NELVLFAFSGFIGLSTLLIILISYLYILITIlRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYSLdqDKVV 250
                        250       260
                 ....*....|....*....|
gi 302563645 272 AIFDAVLTPFLNPVVYTFRN 291
Cdd:cd15230  251 SVFYTVVIPMLNPLIYSLRN 270
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
35-291 3.40e-96

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 285.12  E-value: 3.40e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHL-HSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMV 113
Cdd:cd15935   11 YAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEML 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 114 LLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTY 193
Cdd:cd15935   91 LLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIKLACMDTY 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 194 RLQFMVTVNSGFICVGTFFILLISYIFILFTVRKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMDKFLAI 273
Cdd:cd15935  171 VVEVLMVANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSSSSVDKVASV 250
                        250
                 ....*....|....*...
gi 302563645 274 FDAVLTPFLNPVVYTFRN 291
Cdd:cd15935  251 FYTLITPALNPLIYTLRN 268
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
35-291 3.66e-96

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 285.09  E-value: 3.66e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15937   11 YLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAAEMFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15937   91 LVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIKLACTNTYT 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMDKFLAIF 274
Cdd:cd15937  171 VELLMFSNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSFPMDKVVAVF 250
                        250
                 ....*....|....*..
gi 302563645 275 DAVLTPFLNPVVYTFRN 291
Cdd:cd15937  251 HTVIFPLLNPMIYTLRN 267
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
35-298 4.04e-95

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 282.56  E-value: 4.04e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15229   11 YLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15229   91 LSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSCSDTFA 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQ--MDKFL 271
Cdd:cd15229  171 NKMVLLTSSVIFGLGSFLLTLVSYIHIISTIlRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSASSsvLDRVF 250
                        250       260
                 ....*....|....*....|....*..
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15229  251 SIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
35-291 4.26e-92

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 274.75  E-value: 4.26e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15912   11 YLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTTEFFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15912   91 LAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKLSCSDTRL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMD--KFL 271
Cdd:cd15912  171 IELLDFILASVVLLGSLLLTIVSYIYIISTIlRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQSSSLDlnKVV 250
                        250       260
                 ....*....|....*....|
gi 302563645 272 AIFDAVLTPFLNPVVYTFRN 291
Cdd:cd15912  251 ALLNTVVTPLLNPFIYTLRN 270
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
35-291 1.89e-91

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 272.79  E-value: 1.89e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15227   11 YLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASELAL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15227   91 LTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKLSCSDTYL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRK-HSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPN--SQMDKFL 271
Cdd:cd15227  171 NEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRiPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDspSLLDLLL 250
                        250       260
                 ....*....|....*....|
gi 302563645 272 AIFDAVLTPFLNPVVYTFRN 291
Cdd:cd15227  251 SVFYSVVPPTLNPIIYSLRN 270
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
35-297 3.44e-91

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 272.50  E-value: 3.44e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15421   11 FLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGAECLL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15421   91 LALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLSCADTSA 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHP--NSQMDKFL 271
Cdd:cd15421  171 YETVVYVSGVLFLLIPFSLILASYALILLTVlRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSyhSPEQDKVV 250
                        250       260
                 ....*....|....*....|....*.
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAA 297
Cdd:cd15421  251 SVFYTILTPMLNPLIYSLRNKEVLGA 276
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
35-300 3.54e-90

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 270.28  E-value: 3.54e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15417   11 YLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTECFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15417   91 LAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLSCSDTFI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRK-HSSGGSSKALSTLSAHITVVLLFFGPPVFVYTwpHPNSQ----MDK 269
Cdd:cd15417  171 SQVVLFLVAVLFGVFSVLVVLISYGYIISTILKiRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYL--RPSSShsqdQDK 248
                        250       260       270
                 ....*....|....*....|....*....|.
gi 302563645 270 FLAIFDAVLTPFLNPVVYTFRNKEMKAAIKR 300
Cdd:cd15417  249 VASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
35-298 7.32e-89

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 266.78  E-value: 7.32e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15235   12 YLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15235   92 LAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDTSL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHP--NSQMDKFL 271
Cdd:cd15235  172 NELLIFTEGAVVVLGPFLLIVLSYARILAAVlKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSsySADKDRVA 251
                        250       260
                 ....*....|....*....|....*..
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15235  252 TVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
35-298 3.68e-88

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 264.90  E-value: 3.68e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15231   11 YLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTECLL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15231   91 LAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLKLSCSDTSL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRK-HSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPN--SQMDKFL 271
Cdd:cd15231  171 NEVLLLVASVFIGLTPFLFIVISYVYIISTILKiRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGysLDKDTLI 250
                        250       260
                 ....*....|....*....|....*..
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15231  251 SVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
11-301 1.91e-87

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 263.84  E-value: 1.91e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  11 EFVFLGLTHSWEKQLLLLVFSSVLYVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHK 90
Cdd:cd15943    1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  91 VISFGGCIAQIFFIHVIGGVEMVLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCG 170
Cdd:cd15943   81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 171 PNVLDSFYCDLPRLLRLACTDTYRLQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLL 249
Cdd:cd15943  161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAIlRIHSSEGRRKAFSTCASHLMAVTI 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 302563645 250 FFGPPVFVYTWPHPNSQM--DKFLAIFDAVLTPFLNPVVYTFRNKEMKAAIKRV 301
Cdd:cd15943  241 FYGTTLFMYLRPSSSYSLdqDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRI 294
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
35-291 2.65e-87

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 262.60  E-value: 2.65e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15237   11 YLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVTECVL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15237   91 LAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKLACADTSL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNS--QMDKFL 271
Cdd:cd15237  171 NEAVIFVTSVLVLLIPFSLILASYIRILATIlRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTHspDQDKMI 250
                        250       260
                 ....*....|....*....|
gi 302563645 272 AIFDAVLTPFLNPVVYTFRN 291
Cdd:cd15237  251 SVFYTIVTPMLNPLIYSLRN 270
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
35-291 3.26e-87

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 262.24  E-value: 3.26e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15915   11 YLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEAML 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15915   91 LAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLACGDTSL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFIL-FTVRK-HSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQM--DKF 270
Cdd:cd15915  171 NLWLLNIVTGSIALGTFILTLLSYIYIIsFLLLKvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGDSLeqDRI 250
                        250       260
                 ....*....|....*....|.
gi 302563645 271 LAIFDAVLTPFLNPVVYTFRN 291
Cdd:cd15915  251 VALLYTVVTPVLNPLIYTLRN 271
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
35-291 2.48e-86

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 259.80  E-value: 2.48e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15938   11 YTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15938   91 LTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACTDTCV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRkhSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMDKFLAIF 274
Cdd:cd15938  171 TELLMVSNSGLISTVCFVVLVTSYTTILVTIR--STEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFPVDKHVSVL 248
                        250
                 ....*....|....*..
gi 302563645 275 DAVLTPFLNPVVYTFRN 291
Cdd:cd15938  249 YNVITPMLNPLIYTLRN 265
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
35-298 4.43e-86

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 259.67  E-value: 4.43e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15228   11 YLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTECLL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15228   91 YTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLACADTSI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRK-HSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMDKFLAI 273
Cdd:cd15228  171 AETVSFTNVGLVPLTCFLLILASYVRIVISILKmRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSPVLVTPVQI 250
                        250       260
                 ....*....|....*....|....*
gi 302563645 274 FDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15228  251 FNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
35-291 8.45e-86

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 258.57  E-value: 8.45e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15911   11 YIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATECYL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15911   91 LAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCSDTSL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQ--MDKFL 271
Cdd:cd15911  171 VELVTFILSSIVTLPPFLLTLTSYICIISTIlRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTSrdLNKVF 250
                        250       260
                 ....*....|....*....|
gi 302563645 272 AIFDAVLTPFLNPVVYTFRN 291
Cdd:cd15911  251 SLFYTVLTPLVNPLIYSLRN 270
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
12-295 1.02e-85

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 259.18  E-value: 1.02e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  12 FVFLGLTHSWEKQLLLLVFSSVLYVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKV 91
Cdd:cd15408    1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  92 ISFGGCIAQIFFIHVIGGVEMVLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGP 171
Cdd:cd15408   81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 172 NVLDSFYCDLPRLLRLACTDTYRLQFMVTVNSGFICVGTFFILLISYIFILFTVRK-HSSGGSSKALSTLSAHITVVLLF 250
Cdd:cd15408  161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRmRSAEGRHKAFSTCASHLTAVTLF 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 302563645 251 FGPPVFVYTWP-HPNSQ-MDKFLAIFDAVLTPFLNPVVYTFRNKEMK 295
Cdd:cd15408  241 YGSLAFMYLRPsSRYSLdLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
35-297 7.57e-85

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 256.56  E-value: 7.57e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15429   11 YLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEFIL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15429   91 LAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDTSL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNS--QMDKFL 271
Cdd:cd15429  171 NEVAILVSSVVVLLTPCFLVLLSYIHIISAIlRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSsaLQEKMI 250
                        250       260
                 ....*....|....*....|....*.
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAA 297
Cdd:cd15429  251 SLFYAVVTPMLNPLIYSLRNKEVKGA 276
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
35-300 4.50e-84

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 254.54  E-value: 4.50e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15419   11 YMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEGFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15419   91 LAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLSCSDTFI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQM--DKFL 271
Cdd:cd15419  171 NELVMFVLCGLIIVSTILVILVSYAYILSTIlRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAVSSPeqSKVV 250
                        250       260
                 ....*....|....*....|....*....
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAIKR 300
Cdd:cd15419  251 SVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
35-300 1.67e-83

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 253.10  E-value: 1.67e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15409   11 YLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15409   91 LAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKISCTDPSI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQM--DKFL 271
Cdd:cd15409  171 NELVLFIFSGSIQVFTILTVLISYSYILFTIlKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYALdqDMMD 250
                        250       260
                 ....*....|....*....|....*....
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAIKR 300
Cdd:cd15409  251 SLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
35-291 4.73e-83

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 251.76  E-value: 4.73e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15918   11 YLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDNFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15918   91 LAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCSDTHL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRK-HSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPN--SQMDKFL 271
Cdd:cd15918  171 NELVILVLGGLVGLVPFLCILVSYVRIVSAVLRiPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSShsASKDSVA 250
                        250       260
                 ....*....|....*....|
gi 302563645 272 AIFDAVLTPFLNPVVYTFRN 291
Cdd:cd15918  251 AVMYTVVTPMLNPFIYSLRN 270
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
35-291 4.79e-83

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 251.79  E-value: 4.79e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15232   11 YAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSELLL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15232   91 LTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCSDTSL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPpvFVYTWPHPNS----QMDK 269
Cdd:cd15232  171 NEIMAFVADVFFGVGNFLLTLTSYGFIIRSIlRIRSTEGKKKAFSTCSSHLIVVSLYYST--VIYTYIRPSSsyspEKDK 248
                        250       260
                 ....*....|....*....|..
gi 302563645 270 FLAIFDAVLTPFLNPVVYTFRN 291
Cdd:cd15232  249 VVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
35-291 5.18e-83

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 251.39  E-value: 5.18e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15947   11 YLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGSTECVL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15947   91 LAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIKLACVDTTF 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMD--KFL 271
Cdd:cd15947  171 NELELFVASVFFLLVPLSLILVSYGFIARAVlRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSYSQDqgKFI 250
                        250       260
                 ....*....|....*....|
gi 302563645 272 AIFDAVLTPFLNPVVYTFRN 291
Cdd:cd15947  251 SLFYTVVTPTLNPLIYTLRN 270
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
35-300 2.03e-82

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 250.31  E-value: 2.03e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15411   11 YVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15411   91 LGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDTHV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRK-HSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQ--MDKFL 271
Cdd:cd15411  171 NEMLIFILAGLTLVGSLLIILVSYTYILSTILKiRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSYSlgQDKVA 250
                        250       260
                 ....*....|....*....|....*....
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAIKR 300
Cdd:cd15411  251 SVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
35-298 2.16e-82

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 250.06  E-value: 2.16e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREH-KVISFGGCIAQIFFIHVIGGVEMV 113
Cdd:cd15916   11 YLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFFHFLGSTECF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 114 LLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTY 193
Cdd:cd15916   91 LYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACADTT 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 194 RLQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMDKFLA 272
Cdd:cd15916  171 INELVIFASIGVVALGCFILILLSYGNIVRAIlRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSKEALDGVIA 250
                        250       260
                 ....*....|....*....|....*.
gi 302563645 273 IFDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15916  251 VFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
12-301 5.62e-82

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 249.88  E-value: 5.62e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  12 FVFLGLTHSWEKQLLLLVFSSVLYVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKV 91
Cdd:cd15410    1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  92 ISFGGCIAQIFFIHVIGGVEMVLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGP 171
Cdd:cd15410   81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 172 NVLDSFYCDLPRLLRLACTDTYRLQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLF 250
Cdd:cd15410  161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTIlRIRSAEGRQKAFSTCASHLTAITIF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 302563645 251 FGPPVFVYTWPHPNSQM--DKFLAIFDAVLTPFLNPVVYTFRNKEMKAAIKRV 301
Cdd:cd15410  241 HGTILFMYCRPSSSYSLdtDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKL 293
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
35-300 9.09e-80

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 243.43  E-value: 9.09e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15416   11 YSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVECFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15416   91 LAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKLSCSDIRL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMD--KFL 271
Cdd:cd15416  171 AKILPSISSGIIILVTVLTIIISYLYILIAIlRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYSMDqnKVV 250
                        250       260
                 ....*....|....*....|....*....
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAIKR 300
Cdd:cd15416  251 SVFYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
35-291 1.49e-79

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 242.51  E-value: 1.49e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15431   11 YLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITECLL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFqLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15431   91 LAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVI-PVLTMPLHFCGPNVINHFFCEVQALLKLACSDTSL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNS--QMDKFL 271
Cdd:cd15431  170 NEILMFATSIFTLLLPFSFILVSYIRIGVAVlRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKSssDQDKII 249
                        250       260
                 ....*....|....*....|
gi 302563645 272 AIFDAVLTPFLNPVVYTFRN 291
Cdd:cd15431  250 SVFYGVVTPMLNPLIYSLRN 269
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
35-297 4.14e-79

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 241.85  E-value: 4.14e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15420   11 YIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTECVL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15420   91 LAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLACADTWI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRK-HSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQ--MDKFL 271
Cdd:cd15420  171 NEILIFAGCVFILLGPFSLILISYLHILAAILKiQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNSaeQEKIL 250
                        250       260
                 ....*....|....*....|....*.
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAA 297
Cdd:cd15420  251 SLFYSLFNPMLNPLIYSLRNKQVKGA 276
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
12-300 1.11e-78

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 241.19  E-value: 1.11e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  12 FVFLGLTHSWEKQLLLLVFSSVLYVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKV 91
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  92 ISFGGCIAQIFFIHVIGGVEMVLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGP 171
Cdd:cd15945   81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 172 NVLDSFYCDLPRLLRLACTDTYRLQFMVTVNSGFICVGTFFILLISYIFILFTVRK-HSSGGSSKALSTLSAHITVVLLF 250
Cdd:cd15945  161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKiRSAEGRFKAFSTCASHLTAVGLF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 302563645 251 FGPPVFVYTWPHPNS--QMDKFLAIFDAVLTPFLNPVVYTFRNKEMKAAIKR 300
Cdd:cd15945  241 YGTLLFMYLRPSSSYslDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
35-300 1.33e-77

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 238.08  E-value: 1.33e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15415   11 YFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEGFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15415   91 LAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSDTHI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHP--NSQMDKFL 271
Cdd:cd15415  171 NELLLLTFSGVIAMSTLLTIIISYIFILFAIlRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSqySLEQEKVS 250
                        250       260
                 ....*....|....*....|....*....
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAIKR 300
Cdd:cd15415  251 AVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
35-298 4.35e-77

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 236.51  E-value: 4.35e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15434   11 YLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGGTECVL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15434   91 LAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIKLACVDTTA 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMD--KFL 271
Cdd:cd15434  171 YEATIFALGVFILLFPLSLILVSYGYIARAVlKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSVSQDqgKFL 250
                        250       260
                 ....*....|....*....|....*..
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15434  251 TLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
35-291 2.60e-75

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 231.79  E-value: 2.60e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15224   11 YVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15224   91 LAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCTDMSL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRKHSSG-GSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMD--KFL 271
Cdd:cd15224  171 AELVDFILALIILLVPLLVTVASYICIISTVLRIPSAtGRQKAFSTCASHLTVVIIFYSATLFMYARPKAISSFDsnKLV 250
                        250       260
                 ....*....|....*....|
gi 302563645 272 AIFDAVLTPFLNPVVYTFRN 291
Cdd:cd15224  251 SVLYTVVTPLLNPIIYCLRN 270
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
35-298 4.92e-75

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 231.55  E-value: 4.92e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15942   11 YLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAECFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15942   91 YTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADTAF 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRK-HSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMDKFLAI 273
Cdd:cd15942  171 NELVTFIDIGLVAMTCFLLILMSYVYIVSAILKiPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQDPLDGVVAV 250
                        250       260
                 ....*....|....*....|....*
gi 302563645 274 FDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15942  251 FYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
35-300 4.96e-75

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 231.44  E-value: 4.96e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15413   11 YLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15413   91 LSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCSDTHE 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNS--QMDKFL 271
Cdd:cd15413  171 KELIILIFAGFNLISSLLIVLVSYLFILSAIlRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSHslDTDKMA 250
                        250       260
                 ....*....|....*....|....*....
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAIKR 300
Cdd:cd15413  251 SVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
35-291 7.72e-75

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 230.72  E-value: 7.72e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15914   11 YLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGITECYL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15914   91 LTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLACTDTSL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRK-HSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQM--DKFL 271
Cdd:cd15914  171 NVLVDFVIHAVIILLTFLLILLSYVKIISVVLKiPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSYSLdyDRAI 250
                        250       260
                 ....*....|....*....|
gi 302563645 272 AIFDAVLTPFLNPVVYTFRN 291
Cdd:cd15914  251 AVVYAVLTPFFNPIIYSLRN 270
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
16-301 8.13e-75

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 231.49  E-value: 8.13e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  16 GLTHSWEKQLLLLVFSSVLYVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFG 95
Cdd:cd15406    1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  96 GCIAQIFFIHVIGGVEMVLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLD 175
Cdd:cd15406   81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 176 SFYCDLPRLLRLACTDTYRLQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPP 254
Cdd:cd15406  161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSIlRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 302563645 255 VFVYTWPHPNSQMD--KFLAIFDAVLTPFLNPVVYTFRNKEMKAAIKRV 301
Cdd:cd15406  241 IFMYLKPSSSSSMTqeKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
35-298 4.74e-74

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 228.90  E-value: 4.74e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15432   11 YILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGSTECVL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15432   91 LAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCVDTTA 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMD--KFL 271
Cdd:cd15432  171 NEAELFVISVLLLLIPLGLILISYIFIVRAVlRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNSSHDrgKMV 250
                        250       260
                 ....*....|....*....|....*..
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15432  251 ALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
35-298 1.23e-73

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 227.70  E-value: 1.23e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15424   11 YLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTECLL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15424   91 LGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACADTHI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNS--QMDKFL 271
Cdd:cd15424  171 TEAIVFGAGVLILLVPLSVILTSYGLILASVlQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGStpDRDKQI 250
                        250       260
                 ....*....|....*....|....*..
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15424  251 AVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
35-300 4.77e-73

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 226.51  E-value: 4.77e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15412   11 YLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEYYM 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15412   91 LAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCSDTYV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPhPNS---QMDKF 270
Cdd:cd15412  171 KETAMFIVAGFNLSSSLLIILISYLFILIAIlRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRP-PSEesvEQSKI 249
                        250       260       270
                 ....*....|....*....|....*....|
gi 302563645 271 LAIFDAVLTPFLNPVVYTFRNKEMKAAIKR 300
Cdd:cd15412  250 VAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
35-298 1.64e-72

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 225.11  E-value: 1.64e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHS-PMYFLLANLSFIDLGACSVTSPKMIYDLFR-EHKVISFGGCIAQIFFIHVIGGVEM 112
Cdd:cd15941   11 YLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTlSGRTISFEGCVVQLYAFHFLASTEC 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 113 VLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDT 192
Cdd:cd15941   91 FLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLACADT 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 193 YRLQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMDKFL 271
Cdd:cd15941  171 TINELVILANIGIVAAGCFLLIVISYIYIVAAVlRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSSSQAGAGAP 250
                        250       260
                 ....*....|....*....|....*..
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15941  251 AVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
35-291 1.14e-70

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 219.88  E-value: 1.14e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15913   11 YILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTTECFF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15913   91 LSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLALSCVPAPG 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRKHSSG-GSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQ--MDKFL 271
Cdd:cd15913  171 TELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAaGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGNStgMQKIV 250
                        250       260
                 ....*....|....*....|
gi 302563645 272 AIFDAVLTPFLNPVVYTFRN 291
Cdd:cd15913  251 TLFYSVVTPLLNPLIYSLRN 270
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
35-300 1.51e-70

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 219.98  E-value: 1.51e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15407   11 YLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFATVENFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15407   91 LASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALSCSDIHI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQM--DKFL 271
Cdd:cd15407  171 SEIVLFFLASFNVFFALLVILISYLFIFITIlRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSMdtDKMA 250
                        250       260
                 ....*....|....*....|....*....
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAIKR 300
Cdd:cd15407  251 SVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
12-301 2.68e-70

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 220.04  E-value: 2.68e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  12 FVFLGLTHSWEKQLLLLVFSSVLYVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKV 91
Cdd:cd15944    1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  92 ISFGGCIAQIFFIHVIGGVEMVLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGP 171
Cdd:cd15944   81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 172 NVLDSFYCDLPRLLRLACTDTYRLQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLF 250
Cdd:cd15944  161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAIlRMRSAEGRRKAFSTCASHFTGVTLF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 302563645 251 FGPPVFVYTWPHPNSQM--DKFLAIFDAVLTPFLNPVVYTFRNKEMKAAIKRV 301
Cdd:cd15944  241 YGTVIFMYLRPTSVYSLdqDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKL 293
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
35-291 6.50e-70

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 218.01  E-value: 6.50e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15430   11 YLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECVL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15430   91 LAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVDISL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHP--NSQMDKFL 271
Cdd:cd15430  171 NEIIMLVGNIIFLVIPLLLICISYIFILSTIlRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSknAQISDKLI 250
                        250       260
                 ....*....|....*....|
gi 302563645 272 AIFDAVLTPFLNPVVYTFRN 291
Cdd:cd15430  251 TLFYGVVTPMLNPIIYSLRN 270
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
35-301 1.51e-69

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 217.68  E-value: 1.51e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15414   11 YLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAECFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15414   91 LASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSLSCADTQI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQM--DKFL 271
Cdd:cd15414  171 NKWVLFIMAGALGVLSGLIILVSYIYILIAIlRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSSSLdlDKVV 250
                        250       260       270
                 ....*....|....*....|....*....|
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAIKRV 301
Cdd:cd15414  251 SVFYTAVIPMLNPLIYSLRNKEVKDALRRT 280
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
35-298 1.13e-68

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 215.13  E-value: 1.13e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15234   11 YLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDNFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15234   91 LAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACSDTLI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRK-HSSGGSSKALSTLSAHITVVLLFFGPPVFVY---TWPHpNSQMDKF 270
Cdd:cd15234  171 NNILIYLATVIFGGIPLSGIIFSYYKIVSSILRiPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYissAVTH-SSRKTAV 249
                        250       260
                 ....*....|....*....|....*...
gi 302563645 271 LAIFDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15234  250 ASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
35-301 3.40e-68

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 214.26  E-value: 3.40e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15418   12 YILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSECFL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15418   92 LAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACDDTRV 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNS--QMDKFL 271
Cdd:cd15418  172 YELILYFILGFNVIAPTALILASYTFILAAIlRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSSHtpDRDKVV 251
                        250       260       270
                 ....*....|....*....|....*....|
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAIKRV 301
Cdd:cd15418  252 ALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
35-298 1.37e-67

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 212.28  E-value: 1.37e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15405   11 YVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECYV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15405   91 LTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSCTSTYV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMD--KFL 271
Cdd:cd15405  171 NELVVFVVVGINIIVPSVTIFISYALILSNIlHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGSVNqgKVS 250
                        250       260
                 ....*....|....*....|....*..
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15405  251 SVFYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
35-298 6.05e-67

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 210.80  E-value: 6.05e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15233   11 YIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15233   91 LTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSCSSTHL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHP--NSQMDKFL 271
Cdd:cd15233  171 NELLLFVFAFFMALAPCVLIVVSYAHVVAAVlRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSvySSDKDKVI 250
                        250       260
                 ....*....|....*....|....*..
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15233  251 GILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
35-298 1.47e-65

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 207.34  E-value: 1.47e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15433   11 YLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAECVL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15433   91 LAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLACGDDET 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHP--NSQMDKFL 271
Cdd:cd15433  171 TEVQMFVARVVILLLPAALILGSYGHVAHAVlRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHrySQAHGKFV 250
                        250       260
                 ....*....|....*....|....*..
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15433  251 SLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
35-291 1.52e-65

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 206.95  E-value: 1.52e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15946   11 YLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECTL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15946   91 FSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKLACADTSL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRK-HSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPN--SQMDKFL 271
Cdd:cd15946  171 NEMVDFVLGVIVLVVPLSLILASYVNIFKAILKiRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNysPERDKKI 250
                        250       260
                 ....*....|....*....|
gi 302563645 272 AIFDAVLTPFLNPVVYTFRN 291
Cdd:cd15946  251 SLFYNVFTALLNPVIYSLRN 270
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
35-298 1.90e-64

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 204.23  E-value: 1.90e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15236   11 YLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15236   91 LAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTSL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRK-HSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMDK--FL 271
Cdd:cd15236  171 NELVIFTEGGLLFVLPLLLILGSYIRIAATILKvPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSSDKdiVA 250
                        250       260
                 ....*....|....*....|....*..
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15236  251 SVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
35-298 6.08e-64

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 203.10  E-value: 6.08e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15428   11 YLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITECAL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15428   91 LSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLASTDTHQ 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRKHSSG-GSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNS--QMDKFL 271
Cdd:cd15428  171 AEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLtGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSSTskEYDKMI 250
                        250       260
                 ....*....|....*....|....*..
gi 302563645 272 AIFDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15428  251 SVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
35-298 4.65e-53

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 175.17  E-value: 4.65e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15223   11 YLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAMESSI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15223   91 LLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACGDTTI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRKHSSGGS-SKALSTLSAHITVVLLFFGPPVF---VYTWPHPNSQ-MDK 269
Cdd:cd15223  171 NSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEArSKALNTCGSHLIVILFFYTAVLVsslTYRFGKTIPPdVHV 250
                        250       260
                 ....*....|....*....|....*....
gi 302563645 270 FLAIFDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15223  251 LLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
35-294 1.26e-52

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 174.01  E-value: 1.26e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15917   11 YLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAMESGV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRmCILFLAVAWTLGVSHSLFQLAFLV-NLPFCGPNVLDSFYCDLPRLLRLACTDTy 193
Cdd:cd15917   91 LLAMAFDRYVAICYPLRYTTILTNT-VVGKIGLAILLRAVALIIPLPLLVrRLPYCGSNVISHSYCEHMAVVKLACGDT- 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 194 rlqfmvTVNSGF-----ICVGTFFILLI--SYIFILFTVRKHSSG-GSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNS 265
Cdd:cd15917  169 ------RVNSIYglfvaLLIVGFDLLFIalSYVLILRAVLQLPSKeARLKALSTCGSHICVILIFYTPALFSFLTHRFGH 242
                        250       260       270
                 ....*....|....*....|....*....|...
gi 302563645 266 QMDK----FLAIFDAVLTPFLNPVVYTFRNKEM 294
Cdd:cd15917  243 HVPPhvhiLLANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
35-293 8.26e-51

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 169.01  E-value: 8.26e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15221   11 YIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVTESAI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVShSLFQLAFLVN-LPFCGPNVLDSFYCDLPRLLRLACTDty 193
Cdd:cd15221   91 LLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFC-IVFPFVFLLKrLPYCGHNVIPHTYCEHMGIARLACAD-- 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 194 rlqfmVTVNS------GFICVGTFFILL-ISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVF-VYTW---P 261
Cdd:cd15221  168 -----ITVNIwygltvALLTVGLDVVLIaVSYALILRAVfRLPSKDARLKALSTCGSHVCVILMFYTPAFFsFLTHrfgR 242
                        250       260       270
                 ....*....|....*....|....*....|..
gi 302563645 262 HPNSQMDKFLAIFDAVLTPFLNPVVYTFRNKE 293
Cdd:cd15221  243 HIPRHVHILLANLYVLVPPMLNPIVYGVKTKQ 274
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
35-294 1.21e-50

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 168.71  E-value: 1.21e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15952   11 YLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGMESAV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDtyr 194
Cdd:cd15952   91 LVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACAS--- 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLI--SYIFILFTVRKHSSGGSS-KALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMDKFL 271
Cdd:cd15952  168 IRINIIYGLFAISVLVLDVILIalSYVLILRAVFRLPSHDARlKALSTCGSHVCVILAFYTPALFSFLTHRFGHNIPRYI 247
                        250       260
                 ....*....|....*....|....*..
gi 302563645 272 AIFDA----VLTPFLNPVVYTFRNKEM 294
Cdd:cd15952  248 HILLAnlyvVLPPMLNPVIYGVRTKQI 274
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
35-293 2.97e-50

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 167.68  E-value: 2.97e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15222   11 YLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMESSV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVShSLFQLAFLVN-LPFCGPNVLDSFYCDLPRLLRLACTDTy 193
Cdd:cd15222   91 LLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVL-LLLPLPFLLKrLPFCHSNVLSHSYCLHQDVMKLACSDT- 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 194 rlqfmvTVNS---GFICVGTF-----FILLiSYIFILFTVRKHSSG-GSSKALSTLSAHITVVLLFFGPPVFVYTWPHPN 264
Cdd:cd15222  169 ------RVNSiygLFVVLSTMgldslLILL-SYVLILKTVLGIASReERLKALNTCVSHICAVLIFYVPMIGLSMVHRFG 241
                        250       260       270
                 ....*....|....*....|....*....|...
gi 302563645 265 SQMDKFLAIFDA----VLTPFLNPVVYTFRNKE 293
Cdd:cd15222  242 KHASPLVHVLMAnvylLVPPVLNPIIYSVKTKQ 274
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
35-294 1.25e-47

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 161.04  E-value: 1.25e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15950   11 YVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVESGV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMcILFLAVAWTLGVSHSLFQLAFLV-NLPFCGPNVLDSFYCDLPRLLRLACTDT- 192
Cdd:cd15950   91 LLAMAFDRYVAICHPLRYSAILTSQV-IAQIGLAIVLRALLFMTPLTCLVtSLPYCGSRVVPHSYCEHMAVVKLACADPr 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 193 YRLQFMVTVNSGFICVGTFFIlLISYIFILFTVRKHSSGGSS-KALSTLSAHITVVLLFFGPPVF-VYT--WPH---PNS 265
Cdd:cd15950  170 PSSLYSITGSTLVVGTDSAFI-AVSYGLILRAVLGLSSKEARlKAFSTCGSHVCVILLFYIPGLLsIYTqrFGQgvpPHT 248
                        250       260
                 ....*....|....*....|....*....
gi 302563645 266 QMdkFLAIFDAVLTPFLNPVVYTFRNKEM 294
Cdd:cd15950  249 QV--LLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
35-293 1.45e-45

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 155.50  E-value: 1.45e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15953   11 YIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIMESAV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMS-PRMCILFLAVAwtlgVSHSLFQLA---FLVNLPFCGPNVLDSFYCDLPRLLRLACT 190
Cdd:cd15953   91 LVAMAFDRYVAICNPLRYATILTnSRIAKLGLVGL----IRGVLLILPlplLLSRLPFCANRIIPHTYCEHMAVVKLACG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 191 DT--YRLQFMVTVnsgfICVGTFFILLI--SYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFvYTWPHPNS 265
Cdd:cd15953  167 DTtiNRIYGLVVA----LLVVGLDLLLIalSYALIIRAVlRLSSKKARQKALNTCTAHICVILMSYTPALF-SFLTHRFG 241
                        250       260       270
                 ....*....|....*....|....*....|...
gi 302563645 266 Q-----MDKFLAIFDAVLTPFLNPVVYTFRNKE 293
Cdd:cd15953  242 QgiaphIHIILANLYLLVPPMLNPIIYGVKTKE 274
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
35-293 1.46e-41

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 145.18  E-value: 1.46e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15951   11 YAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMESGI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTyr 194
Cdd:cd15951   91 FVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACADT-- 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 lqfmvTVNSGF-----ICVGTFFILLI--SYIFILFTVRKHSSGGSS-KALSTLSAHITVVLLFFGPPVFVYTWPHPNSQ 266
Cdd:cd15951  169 -----RVSRAYglsvaFLVGGLDVIFIavSYIQILRAVFKLPSKEARlKTFGTCGSHICVILVFYIPALFSFLTHRFGHN 243
                        250       260       270
                 ....*....|....*....|....*....|.
gi 302563645 267 MDKFLAIFDA----VLTPFLNPVVYTFRNKE 293
Cdd:cd15951  244 VPPHVHILIAnvylLVPPMLNPIIYGVRTKQ 274
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
35-295 1.83e-40

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 142.35  E-value: 1.83e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15948   12 FTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMESAV 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMcILFLAVAWTLGVSHSLFQLAFLVN-LPFCGPNVLDSFYCDLPRLLRLACTDTY 193
Cdd:cd15948   92 LLAMAFDRYVAICNPLRYATILTNSV-ITKIGLAALARAVTLMTPLPFLLRrLPYCRSHVIAHCYCEHMAVVKLACGDTR 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 194 RLQFMVTVNSGFICVGTFFILLISYIFILFTVRKHSSGGSS-KALSTLSAHITVVLLFFGPPVFVYTW----PHPNSQMD 268
Cdd:cd15948  171 FNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQlKAFGTCGSHICAILVFYTPVVLSSTMhrfaRHVAPHVH 250
                        250       260
                 ....*....|....*....|....*..
gi 302563645 269 KFLAIFDAVLTPFLNPVVYTFRNKEMK 295
Cdd:cd15948  251 ILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
35-301 3.71e-37

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 133.78  E-value: 3.71e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645   35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDtyr 194
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCAD--- 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  195 lqfmVTVNS---GFICVGTFFI----LLISYIFILFTVRKHSSG-GSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQ 266
Cdd:pfam13853 162 ----IKVNNiygLFVVTSTFGIdsllIVLSYGLILRTVLGIASReGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHN 237
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 302563645  267 MDKFLAIFDA----VLTPFLNPVVYTFRNKEMKAAIKRV 301
Cdd:pfam13853 238 VPPLLQIMMAnaylFFPPVLNPIVYSVKTKQIRDCVKRM 276
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
35-294 5.17e-37

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 133.45  E-value: 5.17e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15956   11 YVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAMESGV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSpRMCILFLAVAWTL-GVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTY 193
Cdd:cd15956   91 LVAMALDRFVAICNPLHYATILT-LEVVAKAGLLLALrGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACGATT 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 194 RLQFMVTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTW----PHPNSQMD 268
Cdd:cd15956  170 VDSLYGLALALFIGGGDVLFIAYSYGLIVKTVlRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMhrfgHSVPSAAH 249
                        250       260
                 ....*....|....*....|....*.
gi 302563645 269 KFLAIFDAVLTPFLNPVVYTFRNKEM 294
Cdd:cd15956  250 VLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
35-295 1.48e-32

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 121.81  E-value: 1.48e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15949   27 YLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSSNEIPLHACLLQMFLIHSFSAIESGI 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTyR 194
Cdd:cd15949  107 FLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWYRTNIIAHSYCEHMAVVGLACGDV-S 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGF--ICVGTFFILLiSYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPV-------FVYTWPHPN 264
Cdd:cd15949  186 INNHYGLTIGFlvLIMDSLFIVL-SYIMILRVVqRLATSEARLKTFGTCVSHVCAILAFYVPIAvsslihrFGQNVPPPT 264
                        250       260       270
                 ....*....|....*....|....*....|.
gi 302563645 265 SQMdkfLAIFDAVLTPFLNPVVYTFRNKEMK 295
Cdd:cd15949  265 HIL---LANFYLLIPPMLNPIVYGVRTKQIQ 292
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
41-287 2.01e-32

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 120.48  E-value: 2.01e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645   41 GNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMI-YDLFREHKVISFGGCIAQIFFIHVIGGVEMVLLIAMA 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLvYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  120 FDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVldsFYCDLPRLLRLACTDTYRLQFMV 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNV---TVCFIDFPEDLSKPVSYTLLISV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  200 TvnsGFICVgtFFILLISYIFILFTVRKHSSGGSS--------KALSTLSAHITVVLLFFGPPVFVYTWP------HPNS 265
Cdd:pfam00001 158 L---GFLLP--LLVILVCYTLIIRTLRKSASKQKSsertqrrrKALKTLAVVVVVFILCWLPYHIVNLLDslaldcELSR 232
                         250       260
                  ....*....|....*....|....
gi 302563645  266 QMDKFLAIFD--AVLTPFLNPVVY 287
Cdd:pfam00001 233 LLDKALSVTLwlAYVNSCLNPIIY 256
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
35-294 5.41e-30

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 114.92  E-value: 5.41e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15954   11 YIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGMESGV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15954   91 LMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACANIRV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRKHSSG-GSSKALSTLSAHITVVLLFFGPPVFV-----YTWPHPNSQMD 268
Cdd:cd15954  171 DAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKeARSKAFSTCTAHICAIVITYTPAFFTffahrFGGHHITPHIH 250
                        250       260
                 ....*....|....*....|....*.
gi 302563645 269 KFLAIFDAVLTPFLNPVVYTFRNKEM 294
Cdd:cd15954  251 IIMANLYLLLPPMMNPIVYGVKTKQI 276
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
35-294 3.28e-29

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 112.55  E-value: 3.28e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15955   11 FLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFESGI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCI-LFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTy 193
Cdd:cd15955   91 LLAMALDRYVAICHPLRHSSILTPQVLLgIGVLVVVRAVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAADDV- 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 194 RLQFMVTVNSGFICVGTFFI-LLISYIFILFTV-RKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPHPNSQMDKFL 271
Cdd:cd15955  170 RVNKIYGLFVAFSILGFDIIfITTSYALIFRAVfRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHHVAPYV 249
                        250       260
                 ....*....|....*....|....*..
gi 302563645 272 AIFDA----VLTPFLNPVVYTFRNKEM 294
Cdd:cd15955  250 HILLSnlylLVPPVLNPIVYGVKTKQI 276
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
36-291 8.53e-25

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 100.83  E-value: 8.53e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLL 115
Cdd:cd00637   10 VVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 116 IAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCdlprllrlactDTYRL 195
Cdd:cd00637   90 TAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWP-----------DLTLS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 196 QFMVTVNSGFICVGTFFILLISYIFILFTVRKHSSGGSS---------------KALSTLSAHITVVLLFFGPPVFVYTW 260
Cdd:cd00637  159 KAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSsssnssrrrrrrrerKVTKTLLIVVVVFLLCWLPYFILLLL 238
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 302563645 261 PHPNSQMDKFLAIFD------AVLTPFLNPVVYTFRN 291
Cdd:cd00637  239 DVFGPDPSPLPRILYflalllAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
36-298 2.70e-17

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 79.91  E-value: 2.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLL 115
Cdd:cd14967   11 LVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCTASILNL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 116 IAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLfqLAFLVNLPFCGPNVLDSFYCDLPrllrlactdtyrL 195
Cdd:cd14967   91 CAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISL--PPLVGWRDETQPSVVDCECEFTP------------N 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 196 QFMVTVNSGFICVGTFFILLISYIFILFTVRKHssggsSKALSTLSAhITVVLLFFGPPVF----VYTWPHPNSQMDKFL 271
Cdd:cd14967  157 KIYVLVSSVISFFIPLLIMIVLYARIFRVARRE-----LKAAKTLAI-IVGAFLLCWLPFFiiylVSAFCPPDCVPPILY 230
                        250       260
                 ....*....|....*....|....*....
gi 302563645 272 AIFD--AVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd14967  231 AVFFwlGYLNSALNPIIYALFNRDFRRAF 259
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
36-298 1.34e-15

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 75.32  E-value: 1.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLL 115
Cdd:cd14969   12 VLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 116 IAMAFDRYAAICKPLHYlTIMSPRMCILFLAVAWTLGVSHSLFqlaflvnlPFCGPNVLDsfycdlPRLLRLACTDTYRL 195
Cdd:cd14969   92 AALAFERYLVIVRPLKA-FRLSKRRALILIAFIWLYGLFWALP--------PLFGWSSYV------PEGGGTSCSVDWYS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 196 QfmVTVNSGFICVGTFF-------ILLISYIFILFTVRKHS-----SGGSSKALSTLSAHITVVLLFFGPPV-FVYTW-P 261
Cdd:cd14969  157 K--DPNSLSYIVSLFVFcfflplaIIIFCYYKIYRTLRKMSkraarRKNSAITKRTKKAEKKVAKMVLVMIVaFLIAWtP 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 302563645 262 ----------HPNSQMDKFLAIFDAVL---TPFLNPVVYTFRNKEMKAAI 298
Cdd:cd14969  235 yavvslyvsfGGESTIPPLLATIPALFaksSTIYNPIIYVFMNKQFRRAL 284
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
38-229 3.69e-13

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 68.51  E-value: 3.69e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  38 SITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLLIA 117
Cdd:cd15083   14 GVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTLAA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 118 MAFDRYAAICKPLHYLTIMSPRMCILFLAVAWtlgvshslFQLAFLVNLPFCGPNVLdsfycdLPRLLRLACTDTYrLQF 197
Cdd:cd15083   94 IAVDRYLVITRPMKASVRISHRRALIVIAVVW--------LYSLLWVLPPLFGWSRY------VLEGLLTSCSFDY-LSR 158
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 302563645 198 MVTVNSGFICVGTF------FILLISYIFILFTVRKHS 229
Cdd:cd15083  159 DDANRSYVICLLIFgfvlplLIIIYCYSFIFRAVRRHE 196
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
36-297 5.99e-10

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 58.81  E-value: 5.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIydLFREHKVISFGGCIAQIFFIHVIGGVEMVLL 115
Cdd:cd14968   12 VLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAI--LISLGLPTNFHGCLFMACLVLVLTQSSIFSL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 116 IAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTlgvshslfqLAFLVNL-PFCGPNVLDSFyCDLPRLLRLAC--TDT 192
Cdd:cd14968   90 LAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWV---------LSFLVGLtPMFGWNNGAPL-ESGCGEGGIQClfEEV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 193 YRLQFMVTVN-SGFICVGTFFILLIsYIFILFTVRK--------HSSGGSSK-------------------ALSTLSAHI 244
Cdd:cd14968  160 IPMDYMVYFNfFACVLVPLLIMLVI-YLRIFRVIRKqlrqieslLRSRRSRStlqkevkaakslaiilflfALCWLPLHI 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 302563645 245 TVVLLFFGPPVFVytwphPNSQMdkFLAIFDAVLTPFLNPVVYTFRNKEMKAA 297
Cdd:cd14968  239 INCITLFCPECKV-----PKILT--YIAILLSHANSAVNPIVYAYRIRKFRQT 284
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
38-297 6.36e-10

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 58.84  E-value: 6.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  38 SITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGAcSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLLIA 117
Cdd:cd14972   12 IVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLA-GIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLASAYSLLA 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 118 MAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVshslfqlaFLVNLPFCGPNVLDSFycdlprllRLACTDTYRLqf 197
Cdd:cd14972   91 IAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSV--------LLALLPVLGWNCVLCD--------QESCSPLGPG-- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 198 mVTVNSGFICVGTFFILLISYIF----ILFTVRKHSSGGSSKALSTLSAH--------ITVVLLFFgppVFVYTW----- 260
Cdd:cd14972  153 -LPKSYLVLILVFFFIALVIIVFlyvrIFWCLWRHANAIAARQEAAVPAQpstsrklaKTVVIVLG---VFLVCWlplli 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 302563645 261 -----PHPNSQMDKF----LAIFDAVLTPFLNPVVYTFRNKEMKAA 297
Cdd:cd14972  229 llvldVLCPSVCDIQavfyYFLVLALLNSAINPIIYAFRLKEMRRA 274
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
36-227 2.72e-09

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 57.26  E-value: 2.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFsVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQI-----FFIHVIGGV 110
Cdd:cd14978   12 IFGIIGNILNLV-VLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFlpyiyPLANTFQTA 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 111 EMVLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRlacT 190
Cdd:cd14978   91 SVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTLLRQ---N 167
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 302563645 191 DTYRLQFMVTVNSGFICVGTFFILLISYIFILFTVRK 227
Cdd:cd14978  168 ETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRK 204
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
36-157 1.89e-08

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 54.53  E-value: 1.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSP-KMIYDLFREHKvisFGGCIAQIFFihVIGGVEMVL 114
Cdd:cd15203   12 VLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPfTLIYTLTKNWP---FGSILCKLVP--SLQGVSIFV 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 302563645 115 ----LIAMAFDRYAAICKPLHylTIMSPRMCILFLAVAWTLGVSHSL 157
Cdd:cd15203   87 stltLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLSL 131
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
35-251 2.01e-08

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 54.60  E-value: 2.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFrEHKVISFGG--CIAQIFFIHVIGGVEM 112
Cdd:cd14997   11 FVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETW-AREPWLLGEfmCKLVPFVELTVAHASV 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 113 VLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSL--FQLAFLVNLPFCGPNVLDSfyCDLPrllrlaCT 190
Cdd:cd14997   90 LTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSpvLFITEFKEEDFNDGTPVAV--CRTP------AD 161
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 302563645 191 DTYRLQFMVTVNSGFICVgTFFILLISYIFILFTVRKHSS----GGSSKALSTLSAH-------ITVVLLFF 251
Cdd:cd14997  162 TFWKVAYILSTIVVFFVV-PLAILSGLYSVICRRLVGHPAlesrRADAANRHTLRSRrqvvymlITVVVLFF 232
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
36-162 3.30e-08

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 53.73  E-value: 3.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSvTSPKMIYDLFREHKVISFGGCiaQIF-FIHVIGG-VEMV 113
Cdd:cd15079   12 IVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMI-KMPIFIYNSFYEGWALGPLGC--QIYaFLGSLSGiGSIW 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 302563645 114 LLIAMAFDRYAAICKPLHyLTIMSPRMCILFLAVAWTLGVSHSLFQLAF 162
Cdd:cd15079   89 TNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYALPWALLPLLF 136
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
36-292 3.38e-08

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 53.76  E-value: 3.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSP-KMIYDLFREHkviSFGG--CIAQIFFIHVIGGVEM 112
Cdd:cd14993   12 LLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPlTLLENVYRPW---VFGEvlCKAVPYLQGVSVSASV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 113 VLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTlgvshslfqLAFLVNLPFCGPNVLDSFYCDLP-RLLRLACTD 191
Cdd:cd14993   89 LTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWV---------IAIIIMLPLLVVYELEEIISSEPgTITIYICTE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 192 TYRLQFM----VTVNSGFICVGTFFILLISYIFILFTV-RKHSSGGSSKALSTLSAH------------ITVVLLFFGP- 253
Cdd:cd14993  160 DWPSPELrkayNVALFVVLYVLPLLIISVAYSLIGRRLwRRKPPGDRGSANSTSSRRilrskkkvarmlIVVVVLFALSw 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 302563645 254 -PVFVY-TWPHPNSQMDKFLAIFDAVLTPFL----------NPVVYTFRNK 292
Cdd:cd14993  240 lPYYVLsILLDFGPLSSEESDENFLLILPFAqllgysnsaiNPIIYCFMSK 290
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
35-248 3.52e-08

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 53.92  E-value: 3.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVT-SPKMIYDLFREH-------KVISFGgciaQIFFIHv 106
Cdd:cd14986   11 FVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTvLTQIIWEATGEWvagdvlcRIVKYL----QVVGLF- 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 107 iggVEMVLLIAMAFDRYAAICKPLHYLTimSPRMCILFLAVAWTlgvshslfqLAFLVNLP----FCGPNVLDSFYcdlp 182
Cdd:cd14986   86 ---ASTYILVSMSLDRYQAIVKPMSSLK--PRKRARLMIVVAWV---------LSFLFSIPqlviFVERELGDGVH---- 147
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 183 rllrlACTDTYRLQFMVTVNSGFICVGTFF----ILLISYIFILFTVRKHSSGGSSKALSTLSAHITVVL 248
Cdd:cd14986  148 -----QCWSSFYTPWQRKVYITWLATYVFVipliILSYCYGRILRTIWIRSRQKTDRPIAPTAMSCRSVS 212
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
39-227 1.02e-07

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 52.41  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  39 ITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPkmIYDLFREHKVISFG--GCIAQIFFIHVIGGVEMVLLI 116
Cdd:cd15336   15 MLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSP--IFFVNSLHKRWIFGekGCELYAFCGALFGITSMITLL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 117 AMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLfqlaflvnLPFCGPnvldSFYcdLPRLLRLACTDTYrLQ 196
Cdd:cd15336   93 AISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSL--------PPLFGW----SAY--VPEGLLTSCTWDY-MT 157
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 302563645 197 FMVTVNS--GFICVGTFFILLI----SYIFILFTVRK 227
Cdd:cd15336  158 FTPSVRAytMLLFCFVFFIPLGiiiyCYLFIFLAIRS 194
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
36-289 1.12e-07

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 52.36  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFID--LGAC--------SVTSPKMIYDLF-REHKVISFGGCIAQIFFI 104
Cdd:cd15312   12 LLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDflLGFLvmpysmvrSVESCWYFGDLFcKIHSSLDMMLSTTSIFHL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 105 HVIggvemvlliamAFDRYAAICKPLHYLTIMSPRMCILFLAVAWtlgvshsLFQLAFLVNLPFCGPNV--LDSFycdlp 182
Cdd:cd15312   92 CFI-----------AVDRYYAVCDPLHYRTKITTPVIKVFLVISW-------SVPCLFAFGVVFSEVNLegIEDY----- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 183 rLLRLACTDTYRLQF-----MVTVNSGFICVGTFFILLisYIFILFTVRKH-------------------SSGGSSKALS 238
Cdd:cd15312  149 -VALVSCTGSCVLIFnklwgVIASLIAFFIPGTVMIGI--YIKIFFVARKHakvinnrpsvtkgdsknklSKKKERKAAK 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 302563645 239 TLSAHITVVLLFFgPPVFVYTWPHPNSQMDKFLAIFDAVL-----TPFLNPVVYTF 289
Cdd:cd15312  226 TLSIVMGVFLLCW-LPFFVATLIDPFLNFSTPVDLFDALVwlgyfNSTCNPLIYGF 280
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
39-297 1.32e-07

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 51.99  E-value: 1.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  39 ITGNILIVFSVTTDPHL-HSPMYFLLANLSFIDLGACSVTSPKMIYDLFR----EHKVIsfggCIAQIFFIHVIGGVEMV 113
Cdd:cd15104   14 ITGNLLVIVALLKLIRKkDTKSNCFLLNLAIADFLVGLAIPGLATDELLSdgenTQKVL----CLLRMCFVITSCAASVL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 114 LLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAW-------------------TLGVSHSLFQLA---FLVNLPFCG- 170
Cdd:cd15104   90 SLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWlysgligflplispqfqqtSYKGKCSFFAAFhprVLLVLSCMVf 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 171 -PNVLDSFYCDLpRLLRLACTDTYRLQFMVTVNSGFIcvgtffillisyifilftvrkHSSGGSS--KALSTLSAHITVV 247
Cdd:cd15104  170 fPALLLFVFCYC-DILKIARVHSRAIYKVEHALARQI---------------------HPRRTLSdfKAARTVAVLIGCF 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 302563645 248 LLFFGPPVF------VYTWPHPNSQMDKFLAIFdAVLTPFLNPVVYTFRNKEMKAA 297
Cdd:cd15104  228 LLSWLPFQItglvqaLCDECKLYDVLEDYLWLL-GLCNSLLNPWIYAFWQKEVRRA 282
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
36-251 1.47e-07

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 51.85  E-value: 1.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDL--GACSVTsPKMIYDLfrehkVISFGGCIAQIFFIHVIGGVEMV 113
Cdd:cd15196   12 VLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLlvALFNVL-PQLIWDI-----TYRFYGGDLLCRLVKYLQVVGMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 114 L----LIAMAFDRYAAICKPLHYLTImSPRMCILFLAVAWTLGVSHSLFQLaFLVNLPFCGPNVLDsfycdlprllrlaC 189
Cdd:cd15196   86 AssyvLVATAIDRYIAICHPLSSHRW-TSRRVHLMVAIAWVLSLLLSIPQL-FIFSYQEVGSGVYD-------------C 150
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302563645 190 TDTYRLQFMVTVNSGFICVGTFF----ILLISYIFILFTVRKhssggssKALSTLSAHITVVLLFF 251
Cdd:cd15196  151 WATFEPPWGLRAYITWFTVAVFVvpliILAFCYGRICYVVWR-------AKIKTVKLTLVVVACYI 209
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
36-151 3.91e-07

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 50.52  E-value: 3.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFID--LGAC--------SVTSPKMIYDLF-REHKVISFGGCIAQIFfi 104
Cdd:cd15317   12 LITVSGNLVVIISISHFKQLHSPTNMLVLSLATADflLGLCvmpfsmirTVETCWYFGDLFcKFHTGLDLLLCTTSIF-- 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 302563645 105 hviggvemvLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTL 151
Cdd:cd15317   90 ---------HLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLV 127
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
36-156 4.33e-07

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 50.43  E-value: 4.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVIsFGGCIAQIFF-IHVIGGVEMVL 114
Cdd:cd15067   11 LVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGYWL-FGRDWCDVWHsFDVLASTASIL 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 302563645 115 -LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHS 156
Cdd:cd15067   90 nLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALIS 132
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
42-298 5.58e-07

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 50.16  E-value: 5.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  42 NILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISfggciAQIFF----IHVIGGVEMVLLIA 117
Cdd:cd15102   18 NLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANILLSGARTLRLSP-----AQWFLregsMFVALSASVFSLLA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 118 MAFDRYAAICKPLHYLTIMSPRMcILFLAVAWTLGVShslfqlafLVNLPFCGPNVLdsfyCDLPR---LLRLactdtYR 194
Cdd:cd15102   93 IAIERHLTMAKMKPYGASKTSRV-LLLIGACWLISLL--------LGGLPILGWNCL----GALDAcstVLPL-----YS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRKHSSG---GSSKALSTLSAHITVVLLF---FGP-------PVFVYTWP 261
Cdd:cd15102  155 KHYVLFCVTIFAGILAAIVALYARIYCLVRASGRKATrasASPRSLALLKTVLIVLLVFiacWGPlfillllDVACPVKT 234
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 302563645 262 HPN-SQMDKFLAIfdAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15102  235 CPIlYKADWFLAL--AVLNSALNPIIYTLRSRELRRAV 270
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
36-228 8.96e-07

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 49.66  E-value: 8.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDL-GACSVTSPKMIYDLFREHkviSFGG--CIAQIFFIHVIGGVEM 112
Cdd:cd15065   11 VLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLlVALLVMTFAVVNDLLGYW---LFGEtfCNIWISFDVMCSTASI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 113 VLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGvshslFQLAFL-VNLPFCGPNVLDSFYCDLPRLLRLACtd 191
Cdd:cd15065   88 LNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILS-----ALISFLpIHLGWHRLSQDEIKGLNHASNPKPSC-- 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 302563645 192 TYRLQFMVTVNSGFICvgtFFI----LLISYIFILFTVRKH 228
Cdd:cd15065  161 ALDLNPTYAVVSSLIS---FYIpclvMLLIYSRLYLYARKH 198
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
37-297 1.28e-06

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 48.86  E-value: 1.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  37 ASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLG-ACSVTSPKMIYDLFREHKvisFGGCIAQIFFI-HVIGGVEMVL 114
Cdd:cd15064   13 ATILGNALVIAAILLTRKLHTPANYLIASLAVADLLvAVLVMPLSAVYELTGRWI---LGQVLCDIWISlDVTCCTASIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 -LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFlvnlpFCGPNVLDSFYCDLPRllrlactdty 193
Cdd:cd15064   90 hLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFG-----WRTPDSEDPSECLISQ---------- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 194 rlQFMVTVNSGFicvGTFFILLIsYIFILFTVRKHSSGGSSKALSTLsAHITVVLLFFGPPVFVYTWPHPNSQMDKFLAI 273
Cdd:cd15064  155 --DIGYTIFSTF---GAFYIPLL-LMLILYWKIYRAAARERKAAKTL-GIILGAFIVCWLPFFLVALIVPLCSHCWIPLA 227
                        250       260       270
                 ....*....|....*....|....*....|
gi 302563645 274 FDAVLT------PFLNPVVYTFRNKEMKAA 297
Cdd:cd15064  228 LKSFFLwlgyfnSLINPLIYTFFNKDFRKA 257
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
38-157 1.32e-06

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 48.99  E-value: 1.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  38 SITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVI-SFGGCIAQIFFIHVIGGVEMVLLI 116
Cdd:cd15005   14 SLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAVLFCFHSAFTLF 93
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 302563645 117 AMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSL 157
Cdd:cd15005   94 CIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAF 134
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
36-130 1.45e-06

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 48.81  E-value: 1.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGC--IAQIFFIHVIGGVemV 113
Cdd:cd15001   11 VLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCkaVAYLQLLSFICSV--L 88
                         90
                 ....*....|....*..
gi 302563645 114 LLIAMAFDRYAAICKPL 130
Cdd:cd15001   89 TLTAISIERYYVILHPM 105
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
36-229 2.12e-06

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 48.47  E-value: 2.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTS-PKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15337   12 ILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGfPLKTISSFNKKWIWGKVACELYGFAGGIFGFMSITT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLfqlaflvnLPFC--GPNVLDSFY--CDLPRLLRLACT 190
Cdd:cd15337   92 LAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSI--------PPFFgwGRYVPEGFQtsCTFDYLSRDLNN 163
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 302563645 191 DTYRLQFMVTvnsGFICvgTFFILLISYIFILFTVRKHS 229
Cdd:cd15337  164 RLFILGLFIF---GFLC--PLLIIIFCYVNIIRAVRNHE 197
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
36-295 2.45e-06

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 48.39  E-value: 2.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIydlfrehkVISFG------GCIAQIFFIHVIGG 109
Cdd:cd15069   12 ALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAI--------TISLGfctdfhSCLFLACFVLVLTQ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 110 VEMVLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTlgvshslfqLAFLVNL-PFCGPNVLDSFY--CDLPR--- 183
Cdd:cd15069   84 SSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWV---------LAFGIGLtPFLGWNKAMSATnnSTNPAdhg 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 184 ------LLRLACTDTYRLQFMVTVNSgFICV-GTFFILLISYIFILF-----------------TVRKHSSGGSSKALST 239
Cdd:cd15069  155 tnhsccLISCLFENVVPMSYMVYFNF-FGCVlPPLLIMLVIYIKIFLvacrqlqrtelmdhsrtTLQREIHAAKSLAIIV 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 302563645 240 -------LSAHITVVLLFFGPpvfvyTWPHPNSQMDKFLAIFDAVLTPFLNPVVYTFRNKEMK 295
Cdd:cd15069  234 gifalcwLPVHILNCITLFQP-----EFSKSKPKWAMNVAILLSHANSVVNPIVYAYRNRDFR 291
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
35-158 2.45e-06

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 48.12  E-value: 2.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHK-VISFGGCIAQIFFIHVIGGVEMV 113
Cdd:cd14979   11 FVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPwAFGDGGCKLYYFLFEACTYATVL 90
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 302563645 114 LLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLF 158
Cdd:cd14979   91 TIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIP 135
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
36-298 2.59e-06

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 48.19  E-value: 2.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLL 115
Cdd:cd15073   12 IISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 116 IAMAFDRYAAICKPLHYLTiMSPRMCILFLAVAWTLGVshslfqlaFLVNLPFCGpnvldsFYCDLPRLLRLACTDTYRL 195
Cdd:cd15073   92 TVVAVDRYLTICRPDLGRK-MTTNTYTVMILLAWTNAF--------FWAAMPLVG------WASYALDPTGATCTINWRK 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 196 Q-------FMVTVNSGFICvgTFFILLISYIFILFTVRKHSSGGSSKALS---TLSAHIT-----VVLLFF---GPPVFV 257
Cdd:cd15073  157 NdssfvsyTMSVIVVNFIV--PLAVMFYCYYNVSRFVKKVLASDCLESVNidwTDQNDVTkmsviMIVMFLvawSPYSIV 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 302563645 258 YTWP---HPNSqMDKFLAIFDAVL---TPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15073  235 CLWAsfgEPKK-IPPWMAIIPPLFaksSTFYNPCIYVIANKKFRRAI 280
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
36-289 2.69e-06

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 47.93  E-value: 2.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFID-LGACSVTSPKMIY---------DLF-REHKVISFGGCIAQIFfi 104
Cdd:cd15055   12 LLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADfLVGLLVMPFSMIRsietcwyfgDTFcKLHSSLDYILTSASIF-- 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 105 hviggvEMVLLiamAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVshsLFQLAFLV-NLPFCGPNVLDSFYCDlpr 183
Cdd:cd15055   90 ------NLVLI---AIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSA---LYSSVLLYdNLNQPGLIRYNSCYGE--- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 184 llrlaCTdtyrlqFMVTVNSGFI-CVGTFF----ILLISYIFILFTVRKH---------------SSGGSS-----KALS 238
Cdd:cd15055  155 -----CV------VVVNFIWGVVdLVLTFIlpctVMIVLYMRIFVVARSQarairshtaqvslegSSKKVSkkserKAAK 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 302563645 239 TLSAHITVVLLFFgPPVFVYTWPHPNSQMDKFLAIFDAVLTPF---LNPVVYTF 289
Cdd:cd15055  224 TLGIVVGVFLLCW-LPYYIVSLVDPYISTPSSVFDVLIWLGYFnscLNPLIYAL 276
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
38-231 5.45e-06

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 46.88  E-value: 5.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  38 SITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLLIA 117
Cdd:cd15074   14 STLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSINTLTA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 118 MAFDRYAAICKPLHYLTIMSPRMCILfLAVAWTLGvshslfqlAFLVNLPFCGPnvldSFYcdLPRLLRLACT-----DT 192
Cdd:cd15074   94 ISIYRYLKICHPPYGPKLSRRHVCIV-IVAIWLYA--------LFWAVAPLVGW----GSY--GPEPFGTSCSidwtgAS 158
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 302563645 193 YRLQFMVTVNSGFICVGTF--FILLISYIFILFTVRKHSSG 231
Cdd:cd15074  159 ASVGGMSYIISIFIFCYLLpvLIIVFSYVKIIRKVKSSRKR 199
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
38-175 7.02e-06

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 46.73  E-value: 7.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  38 SITGNILIVFSVTTDPHLHSPMYFLLANLSFIDL-GACSVTSPKMIYDL-FREHkvisfggciAQIFFIHVIGGVEMV-- 113
Cdd:cd15387   14 ALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLvVAVFQVLPQLIWDItFRFY---------GPDFLCRLVKYLQVVgm 84
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 302563645 114 -----LLIAMAFDRYAAICKPLHYLTIMSPRMCILFlavAWTLGVSHSLFQLaFLVNLPFCGPNVLD 175
Cdd:cd15387   85 fastyMLLLMSIDRCLAICQPLRSLHRRSDRVYVLF---SWLLSLVFSIPQV-HIFSLREVGNGVYD 147
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
35-225 9.55e-06

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 46.55  E-value: 9.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHK-VISFGGCIAQIFFIHVIGGVEMV 113
Cdd:cd15134   11 FVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQYPwVFGEVFCKLRAFLSEMSSYASVL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 114 LLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSL-----FQLAFLVNLPFCGPNVLDSFYCDLPRllrla 188
Cdd:cd15134   91 TITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALpfaiqTRIVYLEYPPTSGEALEESAFCAMLN----- 165
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 302563645 189 ctdTYRLQFMVTVNSGFIcvgtFFILLISYIFILFTV 225
Cdd:cd15134  166 ---EIPPITPVFQLSTFL----FFIIPMIAIIVLYVL 195
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
38-151 2.31e-05

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 44.96  E-value: 2.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  38 SITGNILIVFSVTTDPHLHSPMYFLLANLSFIDL--GACSVTspkmIYDLFREHKVISFGGCIAQIFFI--HVIGGVEMV 113
Cdd:cd15297   14 TIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLiiGVFSMN----LYTLYTVIGYWPLGPVVCDLWLAldYVVSNASVM 89
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 302563645 114 LLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTL 151
Cdd:cd15297   90 NLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVL 127
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
36-154 2.34e-05

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 44.93  E-value: 2.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDL--GACSVTSPKMIYDLFREHKVI--SFGGCIAQIF----FIHVI 107
Cdd:cd15354   12 IISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMlvSVSNAWETITIYLLNNRHLVIedAFVRHIDNVFdsliCISVV 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 302563645 108 GgvEMVLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVS 154
Cdd:cd15354   92 A--SMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTG 136
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
36-154 2.61e-05

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 44.84  E-value: 2.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLL 115
Cdd:cd15085   12 TFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGIVSLWSL 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 302563645 116 IAMAFDRYAAICKPLHYLTIMSPRMC---------ILFLAVAWTLGVS 154
Cdd:cd15085   92 TLLAYERYNVVCKPMGGLKLSTKRGYqgllfiwlfCLFWAVAPLFGWS 139
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
39-157 2.70e-05

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 44.88  E-value: 2.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  39 ITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPkmIYDLFREHKVISFGGCIAQIF-FIHVIGGVEMVL-LI 116
Cdd:cd15325   15 VLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLP--FSAIFEILGYWAFGRVFCNIWaAVDVLCCTASIMsLC 92
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 302563645 117 AMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSL 157
Cdd:cd15325   93 IISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISI 133
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
36-246 4.33e-05

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 44.54  E-value: 4.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIydLFREHKVISFGGCIAQIFFIHVIGGVEMVLL 115
Cdd:cd15068   12 VLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI--TISTGFCAACHGCLFIACFVLVLTQSSIFSL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 116 IAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVshsLFQLAFLVNLPFCGPNVLDSFYCDLPRLLRLAC--TDTY 193
Cdd:cd15068   90 LAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSF---AIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVAClfEDVV 166
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 302563645 194 RLQFMVTVNSgFICVGTFFILLIS-YIFILFTVRKHSSGGSSKALSTLSAHITV 246
Cdd:cd15068  167 PMNYMVYFNF-FACVLVPLLLMLGvYLRIFLAARRQLKQMESQPLPGERARSTL 219
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
36-168 4.42e-05

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 44.39  E-value: 4.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGG--------CIAQIFFIHVI 107
Cdd:cd15350   12 AVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADMGYLNRRGpfetklddIMDSLFCLSLL 91
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 302563645 108 GGVEMVLLIAMafDRYAAICKPLHYLTIMSPRMCILFLAVAWTL----GVSHSLFQLAFLVNLPF 168
Cdd:cd15350   92 GSIFSILAIAA--DRYITIFHALRYHNIMTMRRTLVILAIIWTFcggsGILMILFFHFVATVICF 154
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
36-253 6.76e-05

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 43.80  E-value: 6.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLL 115
Cdd:cd17790   12 LVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVMNL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 116 IAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTlgVSHSLFQLAFLVNLPFCGPNVLDSFYCdlprllrlactdtyRL 195
Cdd:cd17790   92 LIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWL--ISFVLWAPAILFWQYLVGERTVLAGQC--------------YI 155
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 302563645 196 QFMVTVNSGFICVGTFFILLISYIFILFTVRKHSSGGSSKALSTLSAHITVVLLFFGP 253
Cdd:cd17790  156 QFLSQPIITFGTAIAAFYLPVTIMIILYWRIYRETIKEKKAARTLSAILLAFILTWTP 213
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
36-289 7.42e-05

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 43.77  E-value: 7.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFID-LGACSVTSPKMiydlfrehkVISFGGCI-AQIFFIHVIGGVEMV 113
Cdd:cd15314   12 LVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADlLVGGLVMPPSM---------VRSVETCWyFGDLFCKIHSSFDIT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 114 LLIA-------MAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVshslfqlAFLVNLPFCGPNVLDSFYCDlprllr 186
Cdd:cd15314   83 LCTAsilnlcfISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSA-------LVGFGIIFLELNIKGIYYNH------ 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 187 LACTDtYRLQFMVTVNSGFICVGTF----FILLISYIFILFTVRKHS---------SGGSS-----KALSTLsAHITVVL 248
Cdd:cd15314  150 VACEG-GCLVFFSKVSSVVGSVFSFyipaVIMLCIYLKIFLVAQRQArsiqsartkSGASSskmerKATKTL-AIVMGVF 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 302563645 249 LFFGPPVFVYTWPHPNSQMDKFLAIFDAV-----LTPFLNPVVYTF 289
Cdd:cd15314  228 LLCWTPFFLCNIIDPFINYSIPPVLIEVLnwlgySNSTLNPFIYAF 273
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
36-157 7.99e-05

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 43.34  E-value: 7.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSP--------------KMIYDLFREHKVISfggCIAQI 101
Cdd:cd15326   12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPfsatleilgywvfgRIFCDIWAAVDVLC---CTASI 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 302563645 102 FFihviggvemvlLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSL 157
Cdd:cd15326   89 LS-----------LCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISI 133
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
36-150 9.12e-05

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 43.25  E-value: 9.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFID-LGACS-------VTSPKMIYDLFREHKVISFGGCIAQIFFIHVI 107
Cdd:cd15103   12 IVSLLENILVILAIAKNKNLHSPMYFFICSLAVADmLVSVSnaletivIILLNNGYLVPRDSFEQHIDNVIDSMICSSLL 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 302563645 108 GgvEMVLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWT 150
Cdd:cd15103   92 A--SICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWV 132
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
36-295 9.97e-05

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 43.23  E-value: 9.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIydLFREHKVISFGGCIAQIFFIHVIGGVEMVLL 115
Cdd:cd15070   12 LCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAI--VVSLGVTIHFYSCLFMSCLLVVFTHASIMSL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 116 IAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTlgvshslfqLAFLVNL-PFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd15070   90 LAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWL---------VSFLVGLtPMFGWNRKPSLESVNTTPLQCQFTSVMR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVNSGFICVGTFFILLISYIFILFTVRKHSSGGSSK-------------------------ALSTLSAHITVVLL 249
Cdd:cd15070  161 MDYMVYFSFFTWILIPLVIMCALYVDIFYIIRNKLSQNATGfretgafygrefktakslalvlflfAVCWLPLSIINCVV 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 302563645 250 FFGPPVfvytwphPNSQMdkFLAIFDAVLTPFLNPVVYTFRNKEMK 295
Cdd:cd15070  241 YFNPKV-------PKIAL--YLGILLSHANSMMNPIVYACKIKKFK 277
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
36-297 1.02e-04

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 43.09  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSP-KMIYDLFREHkviSFGGCIAQIFF-IHVIGGVEMV 113
Cdd:cd15051   12 LLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPfSAIYELRGEW---PLGPVFCNIYIsLDVMLCTASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 114 L-LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPfcGPNVLDSfycDLPRLLRLACTDT 192
Cdd:cd15051   89 LnLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIHLGWNTP--DGRVQNG---DTPNQCRFELNPP 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 193 YRLqfmvtvnsgFICVGTFFILLI----SYIFILFTVRKH----------SSGGSSKALSTLSAH-----ITVVLLFF-- 251
Cdd:cd15051  164 YVL---------LVAIGTFYLPLLimcgVYLRIFRIAREQakrinaltpaSTANSSKSAATAREHkatvtLAAVLGAFii 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 302563645 252 --GPPVFVYTWP-----HPNSQMDKFLaIFDAVLTPFLNPVVYTFRNKEMKAA 297
Cdd:cd15051  235 cwFPYFTYFTYRglcgdNINETALSVV-LWLGYANSALNPILYAFLNRDFRRA 286
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
36-151 1.23e-04

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 42.92  E-value: 1.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFID--LGAC--------SVTSPKMIYDLF-REHKVISFGGCIAQIFFI 104
Cdd:cd15318   12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADmlLGLTvlpfstirSVESCWYFGDSFcRLHTCLDTLFCLTSIFHL 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 302563645 105 HVIggvemvlliamAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTL 151
Cdd:cd15318   92 CFI-----------SIDRHCAICDPLLYPSKFTIRVACIFIAAGWLV 127
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
36-149 2.34e-04

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 42.18  E-value: 2.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMI--------YDLFREHKVISFGGCIAQIFFIHVI 107
Cdd:cd15352   12 IVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETImiavlnsgYLVISDQFIQHMDNVFDSMICISLV 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 302563645 108 GGVemVLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAW 149
Cdd:cd15352   92 ASI--CNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIW 131
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
38-157 3.10e-04

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 41.71  E-value: 3.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  38 SITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPkmIYDLFREHKVISFGGCIAQIF-FIHVIGGVEMVL-L 115
Cdd:cd15062   14 AIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLP--FSATLEVLGYWAFGRIFCDVWaAVDVLCCTASIMsL 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 302563645 116 IAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSL 157
Cdd:cd15062   92 CVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISI 133
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
35-157 3.15e-04

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 41.50  E-value: 3.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPkmIYDLFREHKVISFGGCIAQIFF-IHVIGGVEMV 113
Cdd:cd15330   11 ILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLP--MAALYQVLNKWTLGQVTCDLFIaLDVLCCTSSI 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 302563645 114 L-LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSL 157
Cdd:cd15330   89 LhLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISI 133
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
41-151 3.93e-04

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 41.51  E-value: 3.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  41 GNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLLIAMAF 120
Cdd:cd15096   17 GNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVYTLVLMSL 96
                         90       100       110
                 ....*....|....*....|....*....|.
gi 302563645 121 DRYAAICKPLHYLTIMSPRMCILFLAVAWTL 151
Cdd:cd15096   97 DRYLAVVHPITSMSIRTERNTLIAIVGIWIV 127
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
39-157 4.61e-04

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 41.10  E-value: 4.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  39 ITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLLIAM 118
Cdd:cd15210   15 VPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLLTLVLI 94
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 302563645 119 AFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSL 157
Cdd:cd15210   95 TLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFL 133
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
39-151 4.75e-04

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 40.89  E-value: 4.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  39 ITGNILIVFSVTTDPHLHSPMYFLLANLSFIDL--GACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVlli 116
Cdd:cd15905   13 IFANLFIILGIACNRKLHNTANYFFLSLLLADLltGVALPFIPGMSNESRRGYHSCLFVYVAPNFLFLSFLANLLMV--- 89
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 302563645 117 amAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTL 151
Cdd:cd15905   90 --HYERYLCIVYPLQYHNFWVHRWVPLALLLTWAL 122
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
36-157 4.89e-04

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 40.95  E-value: 4.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLL 115
Cdd:cd15202   12 VFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVSAYTL 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 302563645 116 IAMAFDRYAAICKPLHYLTimSPRMCILFLAVAWTLGVSHSL 157
Cdd:cd15202   92 TAIAVDRYQAIMHPLKPRI--SKTKAKFIIAVIWTLALAFAL 131
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
36-297 6.22e-04

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 40.79  E-value: 6.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIY---------------DLFREHKVISfggCIAQ 100
Cdd:cd15053   12 LLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYvevnggkwylgpilcDIYIAMDVMC---STAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 101 IFfihviggvemvLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTlgvshslfqLAFLVNLP-FCGPNVLDSfyc 179
Cdd:cd15053   89 IF-----------NLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWV---------VSAAIACPlLFGLNNVPY--- 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 180 DLPRLLRLACTDtyrlqFMV--TVNSGFIcvgTFFILLISYIFILFTVRKHssggsSKALSTLSAHITVVLL----FFGP 253
Cdd:cd15053  146 RDPEECRFYNPD-----FIIysSISSFYI---PCIVMLLLYYRIFRALRRE-----KKATKTLAIVLGVFLFcwlpFFTL 212
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 302563645 254 PVFVYTWPHPNSQ------MDKFLAIFDAVLTPFLNPVVYTFRNKEMKAA 297
Cdd:cd15053  213 NILNAICPKLQNQschvgpALFSLTTWLGYVNSFLNPIIYTIFNIEFRKA 262
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
36-151 7.23e-04

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 40.39  E-value: 7.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDL--GACSVTspkmIYDLFREHKVISFGGCIAQIFFI--HVIGGVE 111
Cdd:cd15298   12 LVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLiiGAFSMN----LYTVYIIKGYWPLGAVVCDLWLAldYVVSNAS 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 302563645 112 MVLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTL 151
Cdd:cd15298   88 VMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVL 127
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
36-151 8.59e-04

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 40.38  E-value: 8.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDL--GACSVTspkmIYDLFREHKVISFGGCIAQIFFI--HVIGGVE 111
Cdd:cd15049   12 LVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLiiGLVSMN----LYTVYLVMGYWPLGPLLCDLWLAldYVASNAS 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 302563645 112 MVLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTL 151
Cdd:cd15049   88 VMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVI 127
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
36-153 8.80e-04

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 40.37  E-value: 8.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMY-FLLANLSFIDLGACSVTSP-KMIYDLFREHKVISFggCIAQIFFIHVIGGVEMV 113
Cdd:cd15320   13 LSTLLGNTLVCAAVIRFRHLRSKVTnFFVISLAVSDLLVAVLVMPwKAVAEIAGFWPFGSF--CNIWVAFDIMCSTASIL 90
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 302563645 114 LLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGV 153
Cdd:cd15320   91 NLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSV 130
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
42-299 8.83e-04

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 40.32  E-value: 8.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  42 NILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLLIAMAFD 121
Cdd:cd15334   18 NSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 122 RYAAICKPLHYLTIMSPRMCILFLAVAWTLGVshslfqlafLVNLPfcgpnvldsfycdlPRLLRLACTDTYRLQFMVTV 201
Cdd:cd15334   98 RYRAITDAVEYARKRTPKHAGIMIAVVWIISI---------FISMP--------------PLFWRHQTTSREDECIIKHD 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 202 NSGFICVGTF--FILLISYIFILFTVRKHSSGGSSKALSTL----SAHITVVLLFFGPPVFVYTWP--HPNSQMDKFLAI 273
Cdd:cd15334  155 HIVFTIYSTFgaFYIPLALILILYYKIYRAATRERKAATTLglilGAFVICWLPFFVKEVIVNTCDscYISEEMSNFLTW 234
                        250       260
                 ....*....|....*....|....*.
gi 302563645 274 FdAVLTPFLNPVVYTFRNKEMKAAIK 299
Cdd:cd15334  235 L-GYINSLINPLIYTIFNEDFKKAFQ 259
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
37-156 9.74e-04

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 40.21  E-value: 9.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  37 ASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLLI 116
Cdd:cd15215   12 ASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGVNTIV 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 302563645 117 AMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHS 156
Cdd:cd15215   92 VVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQS 131
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
36-297 1.05e-03

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 39.89  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSP-KMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15305   12 ILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPvSLIAILYDYAWPLPRYLCPIWISLDVLFSTASIMH 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSlfqlaflVNLPFCGpnvldsFYCDLPRLLRLACtdtyr 194
Cdd:cd15305   92 LCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGIS-------MPIPVIG------LQDDEKVFVNGTC----- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 lqfmVTVNSGFICVGTFF-------ILLISYIFILFTVRKHSSGGSSKALSTLSAHITVVLLFFGPPVFVYTWPH----- 262
Cdd:cd15305  154 ----VLNDENFVLIGSFVaffipliIMVITYCLTIQVLQRQQAINNERRASKVLGIVFFLFLIMWCPFFITNILSvlcke 229
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 302563645 263 --PNSQMDKFLAIFDAV--LTPFLNPVVYTFRNKEMKAA 297
Cdd:cd15305  230 acDQKLMEELLNVFVWVgyVSSGINPLVYTLFNKTYRRA 268
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
36-295 1.05e-03

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 40.15  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGAC-------SVTSPKMIYDLFREhkvisfgGCIAQIFFIHVIG 108
Cdd:cd15075   12 IASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTvfggllsVVTNAVGYFNLGRV-------GCVLEGFAVAFFG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 109 GVEMVLLIAMAFDRYAAICKPLHYLTiMSPRMCILFLAVAWTlgvshslfqLAFLVNLP---------------FCGPNv 173
Cdd:cd15075   85 IAALCTVAVIAVDRLFVVCKPLGTLT-FQTRHALAGIASSWL---------WSLIWNTPplfgwgsyqlegvmtSCAPD- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 174 ldsFYCDLPRLLrlactdTYRLQFMVtvnsgFICVGTFFILLISYIFILFTVRK-----HSSGGSSKALSTLSAHITVVL 248
Cdd:cd15075  154 ---WYSRDPVNV------SYILCYFS-----FCFAIPFAIILVSYGYLLWTLRQvaklgVAEGGSTAKAEVQVARMVVVM 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 302563645 249 LFfgppVFVYTW-PH----------PNSQMDKFLAIFDAVLTP---FLNPVVYTFRNKEMK 295
Cdd:cd15075  220 VM----AFLLCWlPYaafaltvvskPDVYINPLIATVPMYLAKsstVYNPIIYIFMNKQFR 276
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
36-169 1.08e-03

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 39.97  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLL 115
Cdd:cd15390   12 LVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTVAASVFTL 91
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 302563645 116 IAMAFDRYAAICKPLhyLTIMSPRMCILFLAVAWtlgvshslfQLAFLVNLPFC 169
Cdd:cd15390   92 MAISIDRYIAIVHPL--RPRLSRRTTKIAIAVIW---------LASFLLALPQL 134
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
36-153 1.28e-03

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 39.76  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFF--IHVIGGVemV 113
Cdd:cd15209   12 VVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFImgLSVIGSI--F 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 302563645 114 LLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGV 153
Cdd:cd15209   90 NITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTV 129
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
36-151 1.33e-03

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 39.60  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSP-KMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15052   12 IATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLDVLFCTASIMH 91
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTL 151
Cdd:cd15052   92 LCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLI 128
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
36-153 1.37e-03

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 39.72  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMY-FLLANLSFIDLG-ACSVTSPKMIYDLFrehKVISFGG-CIAQIFFIHVIGGVEM 112
Cdd:cd15057   12 LLTLLGNALVIAAVLRFRHLRSKVTnYFIVSLAVSDLLvAILVMPWAAVNEVA---GYWPFGSfCDVWVSFDIMCSTASI 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 302563645 113 VLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGV 153
Cdd:cd15057   89 LNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSA 129
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
42-297 1.37e-03

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 39.80  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  42 NILIVFSVTTDPHLHSPMYFLLANLSFIDLGAcSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLLIAMAFD 121
Cdd:cd15345   18 NLMVLIAIWKNNRFHNRMYFFIGNLALCDLLA-GIAYKVNILMSGKKTFSLSPTQWFLREGSMFVALGASTFSLLAIAIE 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 122 RYAAICKPLHYLTIMSPRMcILFLAVAWTLGVShslfqlafLVNLPFCGPNVLDSFYcDLPRLLRLactdtYRLQFMVTV 201
Cdd:cd15345   97 RHLTMIKMRPYDANKRYRV-FLLIGTCWLISVL--------LGALPILGWNCLDNLP-DCSTILPL-----YSKKYVAFC 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 202 NSGFICVGTFFILLISYIFILFTV---RKHSSGGSSKALSTLSAHITVVLLFFG--PPVF------VYTWPHPNS---QM 267
Cdd:cd15345  162 ISIFIAILVAIVILYARIYILVKSssrRVTNHRNSERSMALLRTVVIVVGVFIAcwSPLFilllidVACEVKQCPilyKA 241
                        250       260       270
                 ....*....|....*....|....*....|
gi 302563645 268 DKFLAIfdAVLTPFLNPVVYTFRNKEMKAA 297
Cdd:cd15345  242 DWFIAL--AVLNSAMNPIIYTLASKEMRRA 269
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
42-298 1.56e-03

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 39.53  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  42 NILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISfggcIAQIFFIHVIGGVEMVLLIAMAFD 121
Cdd:cd15962   18 NAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCGLILNFVFQYVIQSETIS----LITVGFLVASFTASVSSLLAITVD 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 122 RYAAICKPLHYLTIMSPRMCILFLAVAWTLGVshslfqlaFLVNLPFCGPNVLDSF-YCDLPRLLRLACTDTYRLQFMVT 200
Cdd:cd15962   94 RYLSLYNALTYYSEKTVLGVHLMLAATWGVSL--------CLGLLPVLGWNCLEERaSCSIVRPLTKSNVTLLSASFFFI 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 201 vnsgficvgtFFILLISYIFILFTVRKHSS--------------GGSSKALSTLSahitVVLLFFGP---PVFVY--TWP 261
Cdd:cd15962  166 ----------FILMLHLYIKICKIVCRHAHqialqqhfltashyVATKKGVSTLA----IILGTFGAswlPFAIYcvVGD 231
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 302563645 262 HPNSQMDKFLAIFDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15962  232 HEYPAVYTYATLLPATYNSMINPIIYAYRNQEIQRSM 268
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
36-170 1.56e-03

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 39.72  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFrEHKVISFGG--CIAQIFFIHVIGGVEMV 113
Cdd:cd15394   12 LVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAF-EPRGWVFGRfmCYFVFLMQPVTVYVSVF 90
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 302563645 114 LLIAMAFDRYAAICKPLHylTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNLPFCG 170
Cdd:cd15394   91 TLTAIAVDRYYVTVYPLR--RRISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEFKG 145
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
42-298 1.64e-03

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 39.24  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  42 NILIVFSVTTDPHLHSPMYFLLANLSFIDL--GACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGgvemvlLIAMA 119
Cdd:cd15961   18 NAIVVLIIFQNPSLRAPMFLLIGSLALADLlaGIGLILNFIFAYLLQSEAAKLVTVGLIVASFSASVCS------LLAIT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 120 FDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLfqlaflvnLPFCGPNVL-DSFYCDLPRLLRLACTDTYRLQFM 198
Cdd:cd15961   92 VDRYLSLYYALTYNSERTVTFTYVMLVLLWGASICLGL--------LPVMGWNCLaDESTCSVVRPLTKNNAAILSVSFL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 199 VTvnsgficvgtFFILLISYIFILFTVRKHSSG--------------GSSKALSTLSAHITVVLLFFGPPVFV-----YT 259
Cdd:cd15961  164 LM----------FALMLQLYIQICKIVMRHAHQialqhhflatshyvTTRKGVSTLAIILGTFAACWMPFTLYsliadYT 233
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 302563645 260 WPhpnsQMDKFLAIFDAVLTPFLNPVVYTFRNKEMKAAI 298
Cdd:cd15961  234 YP----SIYTYATLLPATYNSIINPVIYAFRNQEIQKAL 268
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
36-150 1.65e-03

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 39.51  E-value: 1.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFID-LGACSVTSPKMIYDLfrehkvISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15353   12 IVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADmLVSVSNGSETVVITL------LNGNDTDAQSFTVNIDNVIDSVI 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 302563645 115 ----------LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWT 150
Cdd:cd15353   86 cssllasicsLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWT 131
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
36-297 1.96e-03

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 39.01  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPkmIYDLFREHKVISFGGCIAQIFFIHVIG--GVEMV 113
Cdd:cd15333   16 LATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMP--ISIVYTVTGTWTLGQVVCDIWLSSDITccTASIL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 114 LLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLaflvnlpfcgpnvldsFYCDLPRLLRLACTDTY 193
Cdd:cd15333   94 HLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPF----------------FWRQAKAEEEVSECVVN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 194 RLQFMVTVNSGFicvGTFFI----LLISYIFILFTVRKHSSGGSSKALSTLSAHITVVLLFFgppVFVYTWPHPNSQMDK 269
Cdd:cd15333  158 TDHILYTVYSTV---GAFYIptllLIALYGRIYVEARARERKATKTLGIILGAFIVCWLPFF---IISLVLPICKDACWF 231
                        250       260       270
                 ....*....|....*....|....*....|...
gi 302563645 270 FLAIFD-----AVLTPFLNPVVYTFRNKEMKAA 297
Cdd:cd15333  232 HLAIFDfftwlGYLNSLINPIIYTMSNEDFKQA 264
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
36-293 2.14e-03

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 39.18  E-value: 2.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLL 115
Cdd:cd15329   12 LGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVLLCTASILNL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 116 IAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAFLVNlpfcgpNVLDSFYCDLprllrlacTDTYRL 195
Cdd:cd15329   92 CAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKN------KVNDPGVCQV--------SQDFGY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 196 QFMVTVnsgficvGTFFILLISYIFILFTVRKHSSGgSSKALSTL----SAHITVVLLFFGPPVF--VYTWPHPNSQMDK 269
Cdd:cd15329  158 QIYATF-------GAFYIPLIVMLVLYYKIYRAAKS-ERKAIKTLgiimGAFTLCWLPFFILALLrpFLKPIKCSCIPLW 229
                        250       260
                 ....*....|....*....|....*.
gi 302563645 270 FLAIFD--AVLTPFLNPVVYTFRNKE 293
Cdd:cd15329  230 LSRLFLwlGYANSFLNPIIYAKFNRE 255
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
36-157 2.26e-03

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 38.86  E-value: 2.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLL 115
Cdd:cd15389   12 VISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYVSTLTL 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 302563645 116 IAMAFDRYAAICKPLHylTIMSPRMCILFLAVAWTLGVSHSL 157
Cdd:cd15389   92 TAIALDRHRVILHPLK--PRITPCQGVVVIAIIWIMASCLSL 131
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
36-151 2.56e-03

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 39.01  E-value: 2.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLL 115
Cdd:cd15056   12 LLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVLLTTASIMHL 91
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 302563645 116 IAMAFDRYAAIC-KPLHYLtiMSPRMCILFLAVAWTL 151
Cdd:cd15056   92 CCIALDRYYAICcQPLVYK--MTPLRVAVMLGGCWVI 126
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
36-153 2.83e-03

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 38.68  E-value: 2.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFF--IHVIGGVemV 113
Cdd:cd15400   12 VVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVmgLSVIGSI--F 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 302563645 114 LLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGV 153
Cdd:cd15400   90 NITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTV 129
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
38-228 2.83e-03

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 38.67  E-value: 2.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  38 SITGNILIVFSVTTDPHLH-SPMYFLLANLSFIDLGACSVTSpkmiYDLFREHkviSFGGCIAQIFFIHVIGGVEMVL-- 114
Cdd:cd15341   14 CILENVAVLYLILSSPKLRrKPSYLFIGSLALADFLASVVFA----CSFVDFH---VFHGVDSSAIFLLKLGGVTMSFta 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 ----LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGvshslfqlAFLVNLPFCGPNVLDsfycdlprlLRLACT 190
Cdd:cd15341   87 slgsLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLT--------ALIAYLPLMGWNCCP---------LNSPCS 149
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 302563645 191 DTYRLQFMVTVNSGFICVGTFFILLI-SYIFILFTVRKH 228
Cdd:cd15341  150 ELFPLIPNDYLLSWLLLVAILLSGIIyTYGHVLWKAHKH 188
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
35-291 2.98e-03

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 38.56  E-value: 2.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd14964    9 TCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGANLASIWT 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTlgvshslfqLAFLVNLPFCGPNVLDSFYCDLPRLLRLACTDTYR 194
Cdd:cd14964   89 TLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWG---------VSLLLSIPPLVGKGAIPRYNTLTGSCYLICTTIYL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 195 LQFMVTVnsgfICVGTFFILLISYIFILFT----VRKHSSGGSSKALSTLSAHIT--------VVLLFFGPPVFVYTWPH 262
Cdd:cd14964  160 TWGFLLV----SFLLPLVAFLVIFSRIVLRlrrrVRAIRSAASLNTDKNLKATKSllilvitfLLCWLPFSIVFILHALV 235
                        250       260       270
                 ....*....|....*....|....*....|..
gi 302563645 263 PNSQMDKFLAIFD---AVLTPFLNPVVYTFRN 291
Cdd:cd14964  236 AAGQGLNLLSILAnllAVLASTLNPFIYCLGN 267
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
39-153 3.34e-03

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 38.56  E-value: 3.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  39 ITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLLIAM 118
Cdd:cd14977   15 IIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQVTSLGVTVFSLCAL 94
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 302563645 119 AFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGV 153
Cdd:cd14977   95 SIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSV 129
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
35-149 3.81e-03

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 38.19  E-value: 3.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLG-ACSVTSPKMIYDLFrEHKVISFGGCIAQIFFIHVIGGVEMV 113
Cdd:cd15012   10 FCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCvGIFCVLQNLSIYLI-PSWPFGEVLCRMYQFVHSLSYTASIG 88
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 302563645 114 LLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAW 149
Cdd:cd15012   89 ILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVW 124
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
43-162 4.04e-03

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 38.21  E-value: 4.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  43 ILIVFSVTTDPHLHSPMYFLLaNLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLLIAMAFDR 122
Cdd:cd15219   20 VLLCFLYSAELRKQVPGIFLL-NLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLTSNAMLSMAALSIDR 98
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 302563645 123 YAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAF 162
Cdd:cd15219   99 WIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFL 138
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
38-162 4.12e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 38.24  E-value: 4.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  38 SITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIF--FIHVIGGVEMV-- 113
Cdd:cd15351   14 SLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMdnVIDTMICSSVVss 93
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 302563645 114 --LLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLFQLAF 162
Cdd:cd15351   94 lsFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIVY 144
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
35-164 4.20e-03

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 38.17  E-value: 4.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTS-PKMIYDLFREHKVISFgGCIAQIFFIHVIGGVEMV 113
Cdd:cd15197   11 FVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVlTDIIWRITVEWRAGDF-ACKVIRYLQVVVTYASTY 89
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 302563645 114 LLIAMAFDRYAAICKPLHYLTimSPRMCILFLAVAWTLGvshSLFQLAFLV 164
Cdd:cd15197   90 VLVALSIDRYDAICHPMNFSQ--SGRQARVLICVAWILS---ALFSIPMLI 135
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
41-157 5.11e-03

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 37.83  E-value: 5.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  41 GNILIVFSVTTDPHLHSPMYFLLANLSFIDLG--ACSVTSPKMIYDLfrEHKVISFGGCIAQIFFIHVIGGVEMVLLIAM 118
Cdd:cd14971   17 GNSLVILVVARNKPMRSTTNLFILNLAVADLTflLFCVPFTATIYPL--PGWVFGDFMCKFVHYFQQVSMHASIFTLVAM 94
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 302563645 119 AFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSL 157
Cdd:cd14971   95 SLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAA 133
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
36-160 5.25e-03

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 37.86  E-value: 5.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLG-ACSVTSPKMIYDL-FRehkvisFGG----CIAQIFFIHVIGG 109
Cdd:cd15386   12 VVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVvALFQVLPQLIWEItYR------FQGpdllCRAVKYLQVLSMF 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 302563645 110 VEMVLLIAMAFDRYAAICKPLHYLTIMSPRMCILfLAVAWTLGVSHSLFQL 160
Cdd:cd15386   86 ASTYMLIMMTVDRYIAVCHPLRTLQQPSRQAYLM-IGATWLLSCILSLPQV 135
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
36-297 6.74e-03

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 37.33  E-value: 6.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLG-ACSVTSPKMIYDLfREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15331   12 LATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMvAVLVMPLSAVYEV-SQHWFLGPEVCDMWISMDVLCCTASILH 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 115 LIAMAFDRYAAICKpLHYLTIMSPRMCILFLAVAWTLGVSHSLfqlaflvnLPFCG---PNVLDSfycdlpRLLRLACTD 191
Cdd:cd15331   91 LVAIALDRYWAVTN-IDYIRRRTAKRILIMIAVVWFVSLIISI--------APLFGwkdEDDLDR------VLKTGVCLI 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 192 TYRLQFMVtvnsgFICVGTFFILLISYIFI---LFTVRKHssggSSKALSTLsAHITVVLLFFGPPVFVYTWPHP---NS 265
Cdd:cd15331  156 SQDYGYTI-----FSTVGAFYVPLLLMIIIywkIYQAAKR----ERKAARTL-AIITGAFVVCWLPFFLVALVMPfcgAW 225
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 302563645 266 QMDKFLAIFDAVLTPF---LNPVVYTFRNKEMKAA 297
Cdd:cd15331  226 QISRFLESFFLWLGYFnslLNPIIYTIFSPDFRGA 260
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
35-150 7.06e-03

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 37.61  E-value: 7.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  35 YVASITGNI--LIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYdLFREHKVISFGG--CIAQIFFIHVIGGV 110
Cdd:cd14981   11 FVFGVLGNLlaLIVLARSSKSHKWSVFYRLVAGLAITDLLGILLTSPVVLA-VYASNFEWDGGQplCDYFGFMMSFFGLS 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 302563645 111 EMVLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWT 150
Cdd:cd14981   90 SLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWA 129
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
38-253 8.31e-03

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 37.31  E-value: 8.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  38 SITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLLIA 117
Cdd:cd15300   14 TIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYVASNASVMNLLV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 118 MAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTlgVSHSLFQLAFLVNLPFCGPNVLDSFYCdlprllrlactdtyRLQF 197
Cdd:cd15300   94 ISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWL--ISFILWAPPILCWQYFVGKRTVPEREC--------------QIQF 157
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 302563645 198 MVTVNSGFICVGTFFILLISYIFILFTVRKHSSGGSSKALSTLSAHITVVLLFFGP 253
Cdd:cd15300  158 LSEPTITFGTAIAAFYIPVSVMTILYCRIYKETIKERKAAQTLSAILLAFIITWTP 213
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
38-151 8.44e-03

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 37.02  E-value: 8.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  38 SITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLLIA 117
Cdd:cd15050   14 TVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIFSLFI 93
                         90       100       110
                 ....*....|....*....|....*....|....
gi 302563645 118 MAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTL 151
Cdd:cd15050   94 LCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLL 127
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
36-253 8.68e-03

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 37.24  E-value: 8.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNI--LIVFSVTTdpHLHSPMYFLLANLSFIDLgACSVTSP-KMIYDLFREHKVISFGGC--IAQIFFIHVIGGV 110
Cdd:cd14982   12 ILGLLGNIlaLWVFLRKM--KKRSPTTIYMINLALADL-LFVLTLPfRIYYYLNGGWWPFGDFLCrlTGLLFYINMYGSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 111 emVLLIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSLfqLAFLVNLPFCGPNVLDSFYCDLPRLLRLACT 190
Cdd:cd14982   89 --LFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASV--PLLLLRSTIAKENNSTTCFEFLSEWLASAAP 164
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 302563645 191 dtyrlqfMVTVNSGFICVGTFFILLISYIFILFTVRK-----HSSGGSSKALSTLSAHITVVLLFFGP 253
Cdd:cd14982  165 -------IVLIALVVGFLIPLLIILVCYSLIIRALRRrskqsQKSVRKRKALRMILIVLAVFLVCFLP 225
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
36-298 9.55e-03

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 37.19  E-value: 9.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSPKMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVLL 115
Cdd:cd15081   24 FASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGFTVSVCGITGLWSL 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 116 IAMAFDRYAAICKPLHYLTiMSPRMCILFLAVAWTLGVShslfqlaflvnlpFCGPNVLD-SFYcdLPRLLRLAC----- 189
Cdd:cd15081  104 TIISWERWVVVCKPFGNIK-FDGKLAIVGIIFSWVWSAV-------------WCAPPIFGwSRY--WPHGLKTSCgpdvf 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645 190 -------TDTYRLQFMVTVnsgfiCVGTFFILLISYIFILFTVR-----KHSSGGSSKALSTLSAHITVVLLFF----GP 253
Cdd:cd15081  168 sgssdpgVQSYMIVLMITC-----CIIPLAIIILCYLQVWLAIRavaqqQKESESTQKAEKEVSRMVVVMIFAYcfcwGP 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 302563645 254 PVFV--YTWPHPNSQMDKFLAIFDAVLTP---FLNPVVYTFRNKEMKAAI 298
Cdd:cd15081  243 YTFFacFAAANPGYAFHPLAAALPAYFAKsatIYNPIIYVFMNRQFRNCI 292
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
36-157 9.69e-03

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 37.22  E-value: 9.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302563645  36 VASITGNILIVFSVTTDPHLHSPMYFLLANLSFIDLGACSVTSP-KMIYDLFREHKVISFGGCIAQIFFIHVIGGVEMVL 114
Cdd:cd15304   12 ILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMH 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 302563645 115 LIAMAFDRYAAICKPLHYLTIMSPRMCILFLAVAWTLGVSHSL 157
Cdd:cd15304   92 LCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISM 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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