NCBI Conserved Domain Search

Conserved domains on [gi|301171613|ref|NP_001180356|]

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histone-lysine N-methyltransferase SUV39H2 isoform 4 [Homo sapiens]

Protein Classification

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List of domain hits

Name

Accession

Description

Interval

E-value

SET super family

cl40432

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...

40-169

7.15e-98

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.

The actual alignment was detected with superfamily member cd10532:

Pssm-ID: 394802 [Multi-domain] Cd Length: 243 Bit Score: 282.55 E-value: 7.15e-98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFST 119
Cdd:cd10532  114 YVGEVITSEEAERRGQFYDSKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFST 193

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 301171613 120 RTINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYL 169
Cdd:cd10532  194 RTIKAGEELTFDYQMKGSGDLSSDSIDNSPAKKRVRTVCKCGAVTCRGYL 243

CD_CSD super family

cl28914

CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains; Members of this ...

1-35

4.09e-20

CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains; Members of this group are chromodomains or chromo shadow domains; these are SH3-fold-beta-barrel domains of the chromo-like superfamily. Chromodomains lack the first strand of the SH3-fold-beta-barrel, this first strand is altered by insertion in the chromo shadow domains. The chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. Chromodomain-containing proteins include: i) those having an N-terminal chromodomain followed by a related chromo shadow domain, such as Drosophila and human heterochromatin protein Su(var)205 (HP1), and mammalian modifier 1 and 2; ii) those having a single chromodomain, such as Drosophila protein Polycomb (Pc), mammalian modifier 3, human Mi-2 autoantigen, and several yeast and Caenorhabditis elegans proteins of unknown function; iii) those having paired tandem chromodomains, such as mammalian DNA-binding/helicase proteins CHD-1 to CHD-4 and yeast protein CHD1; (iv) and elongation factor eEF3, a member of the ATP-binding cassette (ABC) family of proteins, that serves an essential function in the translation cycle of fungi. eEF3 is a soluble factor lacking a transmembrane domain and having two ABC domains arranged in tandem, with a unique chromodomain inserted within the ABC2 domain.

The actual alignment was detected with superfamily member cd18639:

Pssm-ID: 475127 Cd Length: 49 Bit Score: 78.71 E-value: 4.09e-20

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 301171613   1 MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSN 35
Cdd:cd18639   15 QEYYLVKWKGYPDSENTWEPRQNLKCSRLLKQFHK 49

Name

Accession

Description

Interval

E-value

SET_SUV39H2

cd10532

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...

40-169

7.15e-98

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.

Pssm-ID: 380930 [Multi-domain] Cd Length: 243 Bit Score: 282.55 E-value: 7.15e-98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFST 119
Cdd:cd10532  114 YVGEVITSEEAERRGQFYDSKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFST 193

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 301171613 120 RTINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYL 169
Cdd:cd10532  194 RTIKAGEELTFDYQMKGSGDLSSDSIDNSPAKKRVRTVCKCGAVTCRGYL 243

SET

smart00317

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...

40-133

9.58e-29

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues

Pssm-ID: 214614 [Multi-domain] Cd Length: 124 Bit Score: 102.80 E-value: 9.58e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613    40 YLSQVITSEEAERRGQFYDNKGI--TYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDtrlpRIALF 117
Cdd:smart00317  30 YVGEIITSEEAEERPKAYDTDGAkaFYLFDID---SDLCIDARRKGNLARFINHSCEPNCELLFVEVNGDD----RIVIF 102

                           90
                   ....*....|....*.
gi 301171613   118 STRTINAGEELTFDYQ 133
Cdd:smart00317 103 ALRDIKPGEELTIDYG 118

SET

pfam00856

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...

44-132

5.99e-22

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.

Pssm-ID: 459965 [Multi-domain] Cd Length: 115 Bit Score: 85.27 E-value: 5.99e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613   44 VITSEEAERRGQFY-----DNKGITYLFDLDyESDEFTVD--AARYGNVSHFVNHSCDPNLQVFNVFIDnldtRLPRIAL 116
Cdd:pfam00856  24 LITKEEADKRELLYydkleLRLWGPYLFTLD-EDSEYCIDarALYYGNWARFINHSCDPNCEVRVVYVN----GGPRIVI 98

                          90
                  ....*....|....*.
gi 301171613  117 FSTRTINAGEELTFDY 132
Cdd:pfam00856  99 FALRDIKPGEELTIDY 114

SET

COG2940

SET domain-containing protein (function unknown) [General function prediction only];

40-167

5.73e-21

SET domain-containing protein (function unknown) [General function prediction only];

Pssm-ID: 442183 [Multi-domain] Cd Length: 134 Bit Score: 83.09 E-value: 5.73e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFyDNKGITYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQvfnvfidnLDTRLPRIALFST 119
Cdd:COG2940   35 YPGEVITWAEAERREPH-KEPLHTYLFELD---DDGVIDGALGGNPARFINHSCDPNCE--------ADEEDGRIFIVAL 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 301171613 120 RTINAGEELTFDYqmkgsgdisSDSIDHSPAKkrvrtvCKCGavTCRG 167
Cdd:COG2940  103 RDIAAGEELTYDY---------GLDYDEEEYP------CRCP--NCRG 133

CD_SUV39H1_like

cd18639

chromodomain of histone methyltransferase SUV39H1, and similar proteins; CHRomatin ...

1-35

4.09e-20

chromodomain of histone methyltransferase SUV39H1, and similar proteins; CHRomatin Organization Modifier (chromo) domain of human SUV39H1, a histone lysine methyltransferase (HMT) which catalyzes di- and tri-methylation of lysine 9 of histone H3 (H3K9me2/3), leading to heterochromatin formation and gene silencing. H3K9me2/3 represents a specific mark for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3, and/or CBX5) proteins to methylated histones. SUV39H1 mainly functions in heterochromatin regions. The human SUV39H1/2, histone H3K9 methyltransferases, are the mammalian homologs of Drosophila Su(var)3-9 and Schizosaccharomyces pombe Clr4. SUV39H1 contains a chromodomain at its N-terminus and a SET domain at its C-terminus. Although the SET domain performs the catalytic activity, the chromodomain of SUV39H1 is essential for the catalytic activity of SUV39H1. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.

Pssm-ID: 349289 Cd Length: 49 Bit Score: 78.71 E-value: 4.09e-20

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 301171613   1 MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSN 35
Cdd:cd18639   15 QEYYLVKWKGYPDSENTWEPRQNLKCSRLLKQFHK 49

Chromo

pfam00385

Chromo (CHRromatin organization MOdifier) domain;

2-33

1.51e-11

Chromo (CHRromatin organization MOdifier) domain;

Pssm-ID: 459793 [Multi-domain] Cd Length: 52 Bit Score: 56.43 E-value: 1.51e-11

                          10        20        30
                  ....*....|....*....|....*....|...
gi 301171613    2 EYYLVKWKGWPDSTNTWEPLQNL-KCPLLLQQF 33
Cdd:pfam00385  17 EEYLVKWKGYPYDENTWEPEENLsKCPELIEEF 49

CHROMO

smart00298

Chromatin organization modifier domain;

4-33

4.51e-08

Chromatin organization modifier domain;

Pssm-ID: 214605 [Multi-domain] Cd Length: 55 Bit Score: 47.21 E-value: 4.51e-08

                           10        20        30
                   ....*....|....*....|....*....|.
gi 301171613     4 YLVKWKGWPDSTNTWEPLQNLK-CPLLLQQF 33
Cdd:smart00298  20 YLVKWKGYSYSEDTWEPEENLLnCSKKLDNY 50

Name

Accession

Description

Interval

E-value

SET_SUV39H2

cd10532

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...

40-169

7.15e-98

Pssm-ID: 380930 [Multi-domain] Cd Length: 243 Bit Score: 282.55 E-value: 7.15e-98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFST 119
Cdd:cd10532  114 YVGEVITSEEAERRGQFYDSKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFST 193

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 301171613 120 RTINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYL 169
Cdd:cd10532  194 RTIKAGEELTFDYQMKGSGDLSSDSIDNSPAKKRVRTVCKCGAVTCRGYL 243

SET_SUV39H

cd10542

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...

40-169

1.04e-77

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.

Pssm-ID: 380940 [Multi-domain] Cd Length: 245 Bit Score: 231.41 E-value: 1.04e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGITYLFDLDYESD--EFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALF 117
Cdd:cd10542  117 YVGEIITSEEAERRGKIYDANGRTYLFDLDYNDDdcEYTVDAAYYGNISHFINHSCDPNLAVYAVWINHLDPRLPRIAFF 196

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 301171613 118 STRTINAGEELTFDYQMKGSGDISSdsiDHSPAKKRVRTVCKCGAVTCRGYL 169
Cdd:cd10542  197 AKRDIKAGEELTFDYLMTGTGGSSE---STIPKPKDVRVPCLCGSKNCRKYL 245

SET_SUV39H1

cd10525

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...

40-169

1.27e-65

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.

Pssm-ID: 380923 [Multi-domain] Cd Length: 255 Bit Score: 201.27 E-value: 1.27e-65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFST 119
Cdd:cd10525  116 YVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIALFAT 195

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613 120 RTINAGEELTFDYQM----------KGSGDISSDSIDHSPaKKRVRTVCKCGAVTCRGYL 169
Cdd:cd10525  196 RTIRAGEELTFDYNMqvdpvdaestKMDSNFGLAGLPGSP-KKRVRIECKCGVRSCRKYL 254

SET_SETDB-like

cd10538

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...

40-133

2.93e-47

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.

Pssm-ID: 380936 [Multi-domain] Cd Length: 217 Bit Score: 152.91 E-value: 2.93e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGITYLFDLDYESD------EFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPR 113
Cdd:cd10538  118 YVGEVITTSEADRRGKIYDKSGGSYLFDLDEFSDsdgdgeELCVDATFCGNVSRFINHSCDPNLFPFNVVIDHDDLRYPR 197

                         90       100
                 ....*....|....*....|
gi 301171613 114 IALFSTRTINAGEELTFDYQ 133
Cdd:cd10538  198 IALFATRDILPGEELTFDYG 217

SET_SUV39H_Clr4-like

cd20073

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...

40-169

4.96e-39

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.

Pssm-ID: 380999 [Multi-domain] Cd Length: 259 Bit Score: 133.47 E-value: 4.96e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGITYLFDLDYESDE----FTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIA 115
Cdd:cd20073  122 YLGEVITQSEAEIRGKKYDNVGVTYLFDLDLFEDQvdeyYTVDAQYCGDVTRFINHSCDPNLAIYSVLRDKSDSKIYDLA 201

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 301171613 116 LFSTRTINAGEELTFDY-------QMKGSGDISSDSIDHSPAKKRvrtvCKCGAVTCRGYL 169
Cdd:cd20073  202 FFAIKDIPALEELTFDYsgrnnfdQLGFIGNRSNSKYINLKNKRP----CYCGSANCRGWL 258

SET_SETDB1

cd10517

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...

40-169

8.44e-31

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.

Pssm-ID: 380915 [Multi-domain] Cd Length: 288 Bit Score: 112.77 E-value: 8.44e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKgitYLFDLD-----------YESDE----FTVDAARYGNVSHFVNHSCDPNLQVFNVFI 104
Cdd:cd10517  158 YAGQILTEDEANEEGLQYGDE---YFAELDyievveklkegYESDVeehcYIIDAKSEGNLGRYLNHSCSPNLFVQNVFV 234

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 301171613 105 DNLDTRLPRIALFSTRTINAGEELTFDYQMkgsgdissdSIDHSPAKKRvrtVCKCGAVTCRGYL 169
Cdd:cd10517  235 DTHDLRFPWVAFFASRYIRAGTELTWDYNY---------EVGSVPGKVL---YCYCGSSNCRGRL 287

SET_SETD1-like

cd10518

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...

40-166

1.79e-29

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).

Pssm-ID: 380916 Cd Length: 150 Bit Score: 105.37 E-value: 1.79e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGI--TYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDtrlpRIALF 117
Cdd:cd10518   43 YVGEVIRPIVADKREKRYDEEGGggTYMFRID---EDLVIDATKKGNIARFINHSCDPNCYAKIITVDGEK----HIVIF 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 301171613 118 STRTINAGEELTFDYQMkgsgdissdsidhsPAKKRVRTVCKCGAVTCR 166
Cdd:cd10518  116 AKRDIAPGEELTYDYKF--------------PIEDEEKIPCLCGAPNCR 150

SET_EHMT

cd10543

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...

40-166

1.96e-29

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.

Pssm-ID: 380941 [Multi-domain] Cd Length: 231 Bit Score: 107.81 E-value: 1.96e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGqfyDNkgiTYLFDLD-YESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFS 118
Cdd:cd10543  120 YIGELISDSEADSRE---DD---SYLFDLDnKDGETYCIDARRYGNISRFINHLCEPNLIPVRVFVEHQDLRFPRIAFFA 193

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 301171613 119 TRTINAGEELTFDYqmkGSG--DIssdsidhspakKRVRTVCKCGAVTCR 166
Cdd:cd10543  194 SRDIKAGEELGFDY---GEKfwRI-----------KGKYFTCRCGSPKCK 229

SET

smart00317

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...

40-133

9.58e-29

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues

Pssm-ID: 214614 [Multi-domain] Cd Length: 124 Bit Score: 102.80 E-value: 9.58e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613    40 YLSQVITSEEAERRGQFYDNKGI--TYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDtrlpRIALF 117
Cdd:smart00317  30 YVGEIITSEEAEERPKAYDTDGAkaFYLFDID---SDLCIDARRKGNLARFINHSCEPNCELLFVEVNGDD----RIVIF 102

                           90
                   ....*....|....*.
gi 301171613   118 STRTINAGEELTFDYQ 133
Cdd:smart00317 103 ALRDIKPGEELTIDYG 118

SET_SETD2

cd19172

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...

40-169

1.89e-27

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.

Pssm-ID: 380949 [Multi-domain] Cd Length: 142 Bit Score: 99.96 E-value: 1.89e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGITYLFDLDYESDEFtVDAARYGNVSHFVNHSCDPN--LQVFNVfidnldTRLPRIALF 117
Cdd:cd19172   31 YVGEVLDEKEFKRRMKEYAREGNRHYYFMALKSDEI-IDATKKGNLSRFINHSCEPNceTQKWTV------NGELRVGFF 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 301171613 118 STRTINAGEELTFDYQMKGSGDIssdsidhspAKKrvrtvCKCGAVTCRGYL 169
Cdd:cd19172  104 AKRDIPAGEELTFDYQFERYGKE---------AQK-----CYCGSPNCRGYI 141

SET_EZH

cd10519

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...

40-132

4.19e-27

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.

Pssm-ID: 380917 Cd Length: 117 Bit Score: 98.47 E-value: 4.19e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGITYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQVfNVFIDNLDTrlpRIALFST 119
Cdd:cd10519   30 YTGELISQDEADRRGKIYDKYNSSYLFNLN---DQFVVDATRKGNKIRFANHSSNPNCYA-KVMMVNGDH---RIGIFAK 102

                         90
                 ....*....|...
gi 301171613 120 RTINAGEELTFDY 132
Cdd:cd10519  103 RDIEAGEELFFDY 115

SET_SETD2-like

cd10531

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...

40-166

5.32e-27

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.

Pssm-ID: 380929 Cd Length: 136 Bit Score: 98.87 E-value: 5.32e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGITYLFDLDYESDEFtVDAARYGNVSHFVNHSCDPNL--QVFNVFIDnldtrlPRIALF 117
Cdd:cd10531   29 YVGEVIDKKEFKERLDEYEELGKSNFYILSLSDDVV-IDATRKGNLSRFINHSCEPNCetQKWIVNGE------YRIGIF 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 301171613 118 STRTINAGEELTFDYQMKGSGDISsdsidhspakkrvrTVCKCGAVTCR 166
Cdd:cd10531  102 ALRDIPAGEELTFDYNFVNYNEAK--------------QVCLCGAQNCR 136

SET_SUV39H_DIM5-like

cd19473

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...

39-169

7.40e-27

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.

Pssm-ID: 380996 [Multi-domain] Cd Length: 274 Bit Score: 102.01 E-value: 7.40e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  39 NYLSQVITSEEAERRgqfYDNKGIT-----YLFDLDYESDE-----------FTVDAARYGNVSHFVNHSCDPNLQVFNV 102
Cdd:cd19473  134 CYVGEIITPEEAQRR---RDAATIAqrkdvYLFALDKFSDPdsldprlrgdpYEIDGEFMSGPTRFINHSCDPNLRIFAR 210

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 301171613 103 FIDNLDTRLPRIALFSTRTINAGEELTFDYQmkgSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYL 169
Cdd:cd19473  211 VGDHADKHIHDLAFFAIKDIPRGTELTFDYV---DGVTGLDDDAGDEEKEKEMTKCLCGSPKCRGYL 274

SET_EHMT1

cd10535

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...

40-166

1.47e-25

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.

Pssm-ID: 380933 [Multi-domain] Cd Length: 231 Bit Score: 97.70 E-value: 1.47e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQfydnkgITYLFDLDYESDE-FTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFS 118
Cdd:cd10535  120 YVGELISDSEADVREE------DSYLFDLDNKDGEvYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFS 193

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 301171613 119 TRTINAGEELTFDYQMKgSGDISSDSIDhspakkrvrtvCKCGAVTCR 166
Cdd:cd10535  194 TRLIEAGEQLGFDYGER-FWDIKGKLFS-----------CRCGSPKCR 229

SET_NSD

cd19173

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...

38-169

1.34e-24

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.

Pssm-ID: 380950 [Multi-domain] Cd Length: 142 Bit Score: 92.76 E-value: 1.34e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  38 HNYLSQVITSEEAERRGQFYDNKGITYLFDLDYESDeFTVDAARYGNVSHFVNHSCDPNL--QVFNVfidNLDTRlprIA 115
Cdd:cd19173   29 IEYVGELIDEEECRRRLKKAHENNITNFYMLTLDKD-RIIDAGPKGNLSRFMNHSCQPNCetQKWTV---NGDTR---VG 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 301171613 116 LFSTRTINAGEELTFDYQMKGSGDissdsidhspakkrVRTVCKCGAVTCRGYL 169
Cdd:cd19173  102 LFAVRDIPAGEELTFNYNLDCLGN--------------EKKVCRCGAPNCSGFL 141

SET_KMT2A_2B

cd19170

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...

40-170

1.62e-24

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).

Pssm-ID: 380947 [Multi-domain] Cd Length: 152 Bit Score: 92.84 E-value: 1.62e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGI-TYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDtrlpRIALFS 118
Cdd:cd19170   43 YAGEVIRSVLTDKREKYYESKGIgCYMFRID---DDEVVDATMHGNAARFINHSCEPNCYSRVVNIDGKK----HIVIFA 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 301171613 119 TRTINAGEELTFDYQMkgsgdissdsidhspAKKRVRTVCKCGAVTCRGYLN 170
Cdd:cd19170  116 LRRILRGEELTYDYKF---------------PIEDVKIPCTCGSKKCRKYLN 152

SET_SETMAR

cd10544

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...

40-169

6.94e-24

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.

Pssm-ID: 380942 [Multi-domain] Cd Length: 254 Bit Score: 93.90 E-value: 6.94e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGITYLFDL-DYESD----EFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLdtrLPRI 114
Cdd:cd10544  119 YAGEVIGFEEARRRTKSQTKGDMNYIIVLrEHLSSgkvlETFVDPTYIGNIGRFLNHSCEPNLFMVPVRVDSM---VPKL 195

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 301171613 115 ALFSTRTINAGEELTFDYQMKGSGDISSDSI---DHSPAKKrvrtVCKCGAVTCRGYL 169
Cdd:cd10544  196 ALFAARDIVAGEELSFDYSGEFSNSVESVTLarqDESKSRK----PCLCGAENCRGFL 249

SET_EHMT2

cd10533

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...

40-166

3.52e-23

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.

Pssm-ID: 380931 [Multi-domain] Cd Length: 239 Bit Score: 91.62 E-value: 3.52e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRgqfydnKGITYLFDLDYESDE-FTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFS 118
Cdd:cd10533  120 YVGELISDAEADVR------EDDSYLFDLDNKDGEvYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS 193

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 301171613 119 TRTINAGEELTFDYqmkgsGDISSDsidhspAKKRVRTvCKCGAVTCR 166
Cdd:cd10533  194 SRDIRTGEELGFDY-----GDRFWD------IKSKYFT-CQCGSEKCK 229

SET_ASH1L

cd19174

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...

40-170

4.27e-23

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).

Pssm-ID: 380951 [Multi-domain] Cd Length: 141 Bit Score: 88.89 E-value: 4.27e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERR--GQFYDNKGiTYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPN--LQVFNVfidnldTRLPRIA 115
Cdd:cd19174   29 YVGEVVSEQEFRRRmiEQYHNHSH-HYCLNLD---SGMVIDGYRMGNEARFVNHSCDPNceMQKWSV------NGVYRIG 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 301171613 116 LFSTRTINAGEELTFDYQMkgsgdissdsidHSPAKKRVrTVCKCGAVTCRGYLN 170
Cdd:cd19174   99 LFALKDIPAGEELTYDYNF------------HSFNVEKQ-QPCKCGSPNCRGVIG 140

SET_KMT2C_2D

cd19171

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...

40-169

2.11e-22

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.

Pssm-ID: 380948 [Multi-domain] Cd Length: 153 Bit Score: 87.49 E-value: 2.11e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYD--NKGItYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDnldtRLPRIALF 117
Cdd:cd19171   43 YIGEIIRNEVANRREKIYEsqNRGI-YMFRID---NDWVIDATMTGGPARYINHSCNPNCVAEVVTFD----KEKKIIII 114

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 301171613 118 STRTINAGEELTFDYQMkgsgDISSDSiDHSPakkrvrtvCKCGAVTCRGYL 169
Cdd:cd19171  115 SNRRIAKGEELTYDYKF----DFEDDQ-HKIP--------CLCGAPNCRKWM 153

SET_ASHR3-like

cd19175

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...

40-169

5.83e-22

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).

Pssm-ID: 380952 [Multi-domain] Cd Length: 139 Bit Score: 85.93 E-value: 5.83e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGIT--YLFDLDYEsdeFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDtrlpRIALF 117
Cdd:cd19175   29 YVGEVIDDKTCEERLWDMKHKGEKnfYMCEIDKD---MVIDATFKGNLSRFINHSCDPNCELQKWQVDGET----RIGVF 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 301171613 118 STRTINAGEELTFDYQMKGSGdissdsidhsPAKKrvrtvCKCGAVTCRGYL 169
Cdd:cd19175  102 AIRDIKKGEELTYDYQFVQFG----------ADQD-----CHCGSKNCRGKL 138

SET

pfam00856

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...

44-132

5.99e-22

Pssm-ID: 459965 [Multi-domain] Cd Length: 115 Bit Score: 85.27 E-value: 5.99e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613   44 VITSEEAERRGQFY-----DNKGITYLFDLDyESDEFTVD--AARYGNVSHFVNHSCDPNLQVFNVFIDnldtRLPRIAL 116
Cdd:pfam00856  24 LITKEEADKRELLYydkleLRLWGPYLFTLD-EDSEYCIDarALYYGNWARFINHSCDPNCEVRVVYVN----GGPRIVI 98

                          90
                  ....*....|....*.
gi 301171613  117 FSTRTINAGEELTFDY 132
Cdd:pfam00856  99 FALRDIKPGEELTIDY 114

SET_SETD1

cd19169

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...

40-166

5.18e-21

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.

Pssm-ID: 380946 Cd Length: 148 Bit Score: 83.54 E-value: 5.18e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGI--TYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDtrlpRIALF 117
Cdd:cd19169   42 YVGQVIRQSVADEREKRYEAIGIgsSYLFRVD---DDTIIDATKCGNLARFINHSCNPNCYAKIITVESQK----KIVIY 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 301171613 118 STRTINAGEELTFDYQMKgsgdISSDSIDhspakkrvrtvCKCGAVTCR 166
Cdd:cd19169  115 SKRPIAVNEEITYDYKFP----IEDEKIP-----------CLCGAPQCR 148

SET

COG2940

SET domain-containing protein (function unknown) [General function prediction only];

40-167

5.73e-21

SET domain-containing protein (function unknown) [General function prediction only];

Pssm-ID: 442183 [Multi-domain] Cd Length: 134 Bit Score: 83.09 E-value: 5.73e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFyDNKGITYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQvfnvfidnLDTRLPRIALFST 119
Cdd:COG2940   35 YPGEVITWAEAERREPH-KEPLHTYLFELD---DDGVIDGALGGNPARFINHSCDPNCE--------ADEEDGRIFIVAL 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 301171613 120 RTINAGEELTFDYqmkgsgdisSDSIDHSPAKkrvrtvCKCGavTCRG 167
Cdd:COG2940  103 RDIAAGEELTYDY---------GLDYDEEEYP------CRCP--NCRG 133

SET_NSD2

cd19211

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...

32-169

1.22e-20

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).

Pssm-ID: 380988 [Multi-domain] Cd Length: 142 Bit Score: 82.73 E-value: 1.22e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  32 QFSNDkhnYLSQVITSEEAERRGQFYDNKGITYLFDLDYESDEFtVDAARYGNVSHFVNHSCDPNLQVFNVFIdNLDTrl 111
Cdd:cd19211   26 EFVNE---YVGELIDEEECMARIKHAHENDITHFYMLTIDKDRI-IDAGPKGNYSRFMNHSCQPNCETQKWTV-NGDT-- 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 301171613 112 pRIALFSTRTINAGEELTFDYQMKGSGDissdsidhspakkrVRTVCKCGAVTCRGYL 169
Cdd:cd19211   99 -RVGLFAVCDIPAGTELTFNYNLDCLGN--------------EKTVCRCGAPNCSGFL 141

SET_AtSUVH-like

cd10545

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...

40-132

1.86e-20

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.

Pssm-ID: 380943 [Multi-domain] Cd Length: 232 Bit Score: 84.38 E-value: 1.86e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQ----------FYDNKGITYLFDLDYESD-------------EFTVDAARYGNVSHFVNHSCDPN 96
Cdd:cd10545  115 YVGELLDTSEADTRSGnddylfdidnRQTNRGWDGGQRLDVGMSdgerssaedeessEFTIDAGSFGNVARFINHSCSPN 194

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 301171613  97 LQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDY 132
Cdd:cd10545  195 LFVQCVLYDHNDLRLPRVMLFAADNIPPLQELTYDY 230

SET_KMT2A

cd19206

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...

40-170

3.24e-20

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).

Pssm-ID: 380983 [Multi-domain] Cd Length: 154 Bit Score: 81.99 E-value: 3.24e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGI-TYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNlqVFNVFIdNLDTRlPRIALFS 118
Cdd:cd19206   43 YSGNVIRSILTDKREKYYDSKGIgCYMFRID---DSEVVDATMHGNAARFINHSCEPN--CYSRVI-NIDGQ-KHIVIFA 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 301171613 119 TRTINAGEELTFDYQMKgsgdiSSDSIDHSPakkrvrtvCKCGAVTCRGYLN 170
Cdd:cd19206  116 MRKIYRGEELTYDYKFP-----IEDASNKLP--------CNCGAKKCRKFLN 154

CD_SUV39H1_like

cd18639

chromodomain of histone methyltransferase SUV39H1, and similar proteins; CHRomatin ...

1-35

4.09e-20

Pssm-ID: 349289 Cd Length: 49 Bit Score: 78.71 E-value: 4.09e-20

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 301171613   1 MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSN 35
Cdd:cd18639   15 QEYYLVKWKGYPDSENTWEPRQNLKCSRLLKQFHK 49

SET_LegAS4-like

cd10522

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...

40-132

1.46e-19

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.

Pssm-ID: 380920 [Multi-domain] Cd Length: 122 Bit Score: 79.31 E-value: 1.46e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYdnKGITYLFDLDYesDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDnldtRLPRIALFST 119
Cdd:cd10522   32 YTGEVLDRWEEDRDSVYH--YDPLYPFDLNG--DILVIDAGKKGNLTRFINHSDQPNLELIVRTLK----GEQHIGFVAI 103

                         90
                 ....*....|...
gi 301171613 120 RTINAGEELTFDY 132
Cdd:cd10522  104 RDIKPGEELFISY 116

SET_EZH2

cd19218

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...

40-133

2.04e-19

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.

Pssm-ID: 380995 Cd Length: 120 Bit Score: 78.80 E-value: 2.04e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGITYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQVfNVFIDNLDTrlpRIALFST 119
Cdd:cd19218   33 YCGEIISQDEADRRGKVYDKYMCSFLFNLN---NDFVVDATRKGNKIRFANHSVNPNCYA-KVMMVNGDH---RIGIFAK 105

                         90
                 ....*....|....
gi 301171613 120 RTINAGEELTFDYQ 133
Cdd:cd19218  106 RAIQTGEELFFDYR 119

SET_SETDB

cd10541

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...

40-169

8.91e-19

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.

Pssm-ID: 380939 [Multi-domain] Cd Length: 236 Bit Score: 79.90 E-value: 8.91e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFydnKGITYLFDLDY-ESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFS 118
Cdd:cd10541  121 YAGKILTDDFADKEGLE---MGDEYFANLDHiEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFA 197

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 301171613 119 TRTINAGEELTFDYQMKgsgdissdsIDHSPAKKrvrTVCKCGAVTCRGYL 169
Cdd:cd10541  198 SKRIKAGTELTWDYNYE---------VGSVEGKE---LLCCCGSNECRGRL 236

SET_SET1

cd20072

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...

40-166

9.02e-19

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).

Pssm-ID: 380998 Cd Length: 148 Bit Score: 77.85 E-value: 9.02e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGI--TYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDtrlpRIALF 117
Cdd:cd20072   42 YVGEVIRQQVADEREKRYLRQGIgsSYLFRID---DDTVVDATKKGNIARFINHCCDPNCTAKIIKVEGEK----RIVIY 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 301171613 118 STRTINAGEELTFDYQMKGSGDissdsidhspakkrvRTVCKCGAVTCR 166
Cdd:cd20072  115 AKRDIAAGEELTYDYKFPREED---------------KIPCLCGAPNCR 148

SET_NSD1

cd19210

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...

32-169

2.73e-18

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.

Pssm-ID: 380987 [Multi-domain] Cd Length: 142 Bit Score: 76.50 E-value: 2.73e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  32 QFSNDkhnYLSQVITSEEAERRGQFYDNKGITYLFDLDYESDEFtVDAARYGNVSHFVNHSCDPNLQVfNVFIDNLDTrl 111
Cdd:cd19210   26 EFVNE---YVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRI-IDAGPKGNYARFMNHCCQPNCET-QKWTVNGDT-- 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613 112 pRIALFSTRTINAGEELTFDYQMK--GSGdissdsidhspakkrvRTVCKCGAVTCRGYL 169
Cdd:cd19210   99 -RVGLFALCDIKAGTELTFNYNLEclGNG----------------KTVCKCGAPNCSGFL 141

SET_SETDB2

cd10523

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...

75-169

3.60e-18

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.

Pssm-ID: 380921 [Multi-domain] Cd Length: 266 Bit Score: 78.72 E-value: 3.60e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  75 FTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYqmkgsgdiSSDSidHSPAKKRV 154
Cdd:cd10523  184 CFLDASKEGNVGRFLNHSCCPNLFVQNVFVDTHDKNFPWVAFFTNRVVKAGTELTWDY--------SYDA--GTSPEQEI 253

                         90
                 ....*....|....*
gi 301171613 155 RtvCKCGAVTCRGYL 169
Cdd:cd10523  254 P--CLCGVNKCQKKI 266

SET_EZH1

cd19217

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...

40-133

6.45e-17

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.

Pssm-ID: 380994 Cd Length: 136 Bit Score: 72.79 E-value: 6.45e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGITYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDtrlpRIALFST 119
Cdd:cd19217   35 YCGELISQDEADRRGKVYDKYMSSFLFNLN---NDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDH----RIGIFAK 107

                         90
                 ....*....|....
gi 301171613 120 RTINAGEELTFDYQ 133
Cdd:cd19217  108 RAIQQGEELFFDYR 121

SET_NSD3

cd19212

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...

25-169

7.06e-17

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.

Pssm-ID: 380989 [Multi-domain] Cd Length: 142 Bit Score: 72.65 E-value: 7.06e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  25 KCPLLLQQFSNDkhnYLSQVITSEEAERRGQFYDNKGITYLFDLDYESDEFtVDAARYGNVSHFVNHSCDPNLQVfNVFI 104
Cdd:cd19212   19 KRSIKKGEFVNE---YVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRI-IDAGPKGNYSRFMNHSCNPNCET-QKWT 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 301171613 105 DNLDTrlpRIALFSTRTINAGEELTFDYQMK--GSGdissdsidhspakkrvRTVCKCGAVTCRGYL 169
Cdd:cd19212   94 VNGDV---RVGLFALCDIPAGMELTFNYNLDclGNG----------------RTECHCGADNCSGFL 141

SET_KMT2B

cd19207

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...

40-170

6.43e-16

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.

Pssm-ID: 380984 [Multi-domain] Cd Length: 154 Bit Score: 70.82 E-value: 6.43e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGI-TYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDtrlpRIALFS 118
Cdd:cd19207   43 YSGIVIRSVLTDKREKFYDSKGIgCYMFRID---DFDVVDATMHGNAARFINHSCEPNCYSRVIHVEGQK----HIVIFA 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 301171613 119 TRTINAGEELTFDYQMKgsgdiSSDSIDHSPakkrvrtvCKCGAVTCRGYLN 170
Cdd:cd19207  116 LRKIYRGEELTYDYKFP-----IEDASNKLP--------CNCGAKRCRRFLN 154

SET

cd08161

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...

85-132

1.29e-14

Pssm-ID: 380914 [Multi-domain] Cd Length: 72 Bit Score: 64.96 E-value: 1.29e-14

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 301171613  85 VSHFVNHSCDPNLQVFNVFIDnldtRLPRIALFSTRTINAGEELTFDY 132
Cdd:cd08161   28 LARFINHSCEPNCEFEEVYVG----GKPRVFIVALRDIKAGEELTVDY 71

SET_SETD1B

cd19205

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...

40-170

1.81e-14

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.

Pssm-ID: 380982 [Multi-domain] Cd Length: 153 Bit Score: 67.00 E-value: 1.81e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGI--TYLFDLDYESdefTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDtrlpRIALF 117
Cdd:cd19205   43 YVGQNIRQVIADMREKRYEDEGIgsSYMFRVDHDT---IIDATKCGNFARFINHSCNPNCYAKVITVESQK----KIVIY 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 301171613 118 STRTINAGEELTFDYQMKgsgdISSDSIDhspakkrvrtvCKCGAVTCRGYLN 170
Cdd:cd19205  116 SKQHINVNEEITYDYKFP----IEDVKIP-----------CLCGSENCRGTLN 153

SET_SETD1A

cd19204

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...

40-170

2.38e-14

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.

Pssm-ID: 380981 [Multi-domain] Cd Length: 153 Bit Score: 66.59 E-value: 2.38e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGI--TYLFDLDYESdefTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDtrlpRIALF 117
Cdd:cd19204   43 YVGQNIRQVVADMREKRYVQEGIgsSYLFRVDHDT---IIDATKCGNLARFINHCCTPNCYAKVITIESQK----KIVIY 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 301171613 118 STRTINAGEELTFDYQMKgsgdISSDSIDhspakkrvrtvCKCGAVTCRGYLN 170
Cdd:cd19204  116 SKQPIGVNEEITYDYKFP----IEDNKIP-----------CLCGTENCRGTLN 153

SET_KMT2D

cd19209

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...

40-169

6.41e-14

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.

Pssm-ID: 380986 [Multi-domain] Cd Length: 155 Bit Score: 65.49 E-value: 6.41e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYD--NKGItYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDtrlpRIALF 117
Cdd:cd19209   45 YIGTIIRNEVANRREKIYEeqNRGI-YMFRIN---NEHVIDATLTGGPARYINHSCAPNCVAEVVTFDKED----KIIII 116

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 301171613 118 STRTINAGEELTFDYQMkgsgDISSDSIDhspakkrvrTVCKCGAVTCRGYL 169
Cdd:cd19209  117 SSRRIPKGEELTYDYQF----DFEDDQHK---------IPCHCGAWNCRKWM 155

SET_KMT2C

cd19208

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...

40-169

1.94e-13

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.

Pssm-ID: 380985 [Multi-domain] Cd Length: 154 Bit Score: 64.26 E-value: 1.94e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYD--NKGItYLFDLDyesDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDnldtRLPRIALF 117
Cdd:cd19208   44 YIGTIIRNEVANRKEKLYEsqNRGV-YMFRID---NDHVIDATLTGGPARYINHSCAPNCVAEVVTFE----KGHKIIIS 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 301171613 118 STRTINAGEELTFDYQMkgsgDISSDsidhspakkRVRTVCKCGAVTCRGYL 169
Cdd:cd19208  116 SSRRIQKGEELCYDYKF----DFEDD---------QHKIPCHCGAVNCRKWM 154

SET_EZH-like

cd19168

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...

40-132

5.16e-13

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.

Pssm-ID: 380945 Cd Length: 124 Bit Score: 62.21 E-value: 5.16e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGITYLFDLDyesDEFTVDAARYGNVSHFVNHSCDP----NLQVFNVFidnlDTRLPRIA 115
Cdd:cd19168   31 YTGELISHDEGVRREHRRGDVSYLYLFEEQ---EGIWVDAAIYGNLSRYINHATDKvktgNCMPKIMY----VNHEWRIK 103

                         90
                 ....*....|....*..
gi 301171613 116 LFSTRTINAGEELTFDY 132
Cdd:cd19168  104 FTAIKDIKIGEELFFNY 120

SET_SETD8

cd10528

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...

44-132

2.43e-12

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.

Pssm-ID: 380926 [Multi-domain] Cd Length: 141 Bit Score: 60.67 E-value: 2.43e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  44 VITSEEAERRGQFY--DNKGITYLFDLDYESDEFTVDAA----RYGnvsHFVNHSC-DPNLQVFNVFIDNLdtrlPRIAL 116
Cdd:cd10528   50 LITITEAKKREALYakDPSTGCYMYYFQYKGKTYCVDATkesgRLG---RLINHSKkKPNLKTKLLVIDGV----PHLIL 122

                         90
                 ....*....|....*.
gi 301171613 117 FSTRTINAGEELTFDY 132
Cdd:cd10528  123 VAKRDIKPGEELLYDY 138

Chromo

pfam00385

Chromo (CHRromatin organization MOdifier) domain;

2-33

1.51e-11

Chromo (CHRromatin organization MOdifier) domain;

Pssm-ID: 459793 [Multi-domain] Cd Length: 52 Bit Score: 56.43 E-value: 1.51e-11

                          10        20        30
                  ....*....|....*....|....*....|...
gi 301171613    2 EYYLVKWKGWPDSTNTWEPLQNL-KCPLLLQQF 33
Cdd:pfam00385  17 EEYLVKWKGYPYDENTWEPEENLsKCPELIEEF 49

CD_CSD

cd00024

CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains; Members of this ...

3-33

8.13e-11

Pssm-ID: 349274 [Multi-domain] Cd Length: 50 Bit Score: 54.41 E-value: 8.13e-11

                         10        20        30
                 ....*....|....*....|....*....|..
gi 301171613   3 YYLVKWKGWPDSTNTWEPLQNLK-CPLLLQQF 33
Cdd:cd00024   17 EYLVKWKGYPPEENTWEPEENLTnAPELIKEY 48

SET_SpSET3-like

cd19183

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...

77-133

1.25e-10

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.

Pssm-ID: 380960 Cd Length: 173 Bit Score: 57.03 E-value: 1.25e-10

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 301171613  77 VDAARYGNVSHFVNHSCDPNLQVFNVFIDNLdtRLPRIALFSTRTINAGEELTFDYQ 133
Cdd:cd19183   69 IDTRRSGSVARFIRRSCRPNAELVTVASDSG--SVLKFVLYASRDISPGEEITIGWD 123

CD_HP1a_insect

cd18653

chromodomain of insect HP1a; CHRomatin Organization Modifier (chromo) domain of insect HP1a. ...

1-33

1.50e-10

chromodomain of insect HP1a; CHRomatin Organization Modifier (chromo) domain of insect HP1a. HP1a is a member of the heterochromatin protein family, and is enriched in the heterochromatin and associated with centromeres. HP1 has diverse functions in heterochromatin formation and impacts both gene expression and gene silencing. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. In Drosophila, there are at least five HP1 family proteins, this subgroup includes the CD of Drosophila melanogaster HP1a.

Pssm-ID: 349300 Cd Length: 50 Bit Score: 53.88 E-value: 1.50e-10

                         10        20        30
                 ....*....|....*....|....*....|...
gi 301171613   1 MEYYLvKWKGWPDSTNTWEPLQNLKCPLLLQQF 33
Cdd:cd18653   17 VEYYL-KWKGYPETENTWEPEENLDCQDLIQQY 48

SET_SETD5-like

cd10529

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...

40-132

1.65e-10

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.

Pssm-ID: 380927 Cd Length: 127 Bit Score: 55.74 E-value: 1.65e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYdNKGITYLFDLD-YESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNldTRLpRIALFS 118
Cdd:cd10529   34 YKGEVSLRSEFKEDNGFF-KRPSPFVFFYDgFEGLPLCVDARKYGNEARFIRRSCRPNAELRHVVVSN--GEL-RLFIFA 109

                         90
                 ....*....|....*.
gi 301171613 119 TRTINAGEELT--FDY 132
Cdd:cd10529  110 LKDIRKGTEITipFDY 125

CD_HP1_like

cd18631

chromodomain of heterochromatin protein 1 proteins, including HP1alpha, HP1beta, and HP1gamma; ...

4-35

1.77e-10

chromodomain of heterochromatin protein 1 proteins, including HP1alpha, HP1beta, and HP1gamma; CHRomatin Organization Modifier (chromo) domain of mammalian HP1alpha (Cbx5), HP1beta (Cbx1), HP1gamma (Cbx5), and similar proteins. HP1 has diverse functions in heterochromatin formation and impacts both gene expression and gene silencing. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. There are three human homologs of HP1 proteins: HP1alpha (also known as Cbx5), HP1beta (also known as Cbx1), and HP1gamma (also known as Cbx3).

Pssm-ID: 349281 Cd Length: 50 Bit Score: 53.60 E-value: 1.77e-10

                         10        20        30
                 ....*....|....*....|....*....|..
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSN 35
Cdd:cd18631   19 YLLKWKGYPDEDNTWEPEENLDCPDLIAEFEE 50

CD_HP1gamma_Cbx3

cd18652

chromodomain of heterochromatin protein 1 homolog gamma; CHRomatin Organization Modifier ...

1-35

3.21e-09

chromodomain of heterochromatin protein 1 homolog gamma; CHRomatin Organization Modifier (chromo) domain of heterochromatin protein 1 homolog gamma (also known as HP1gamma, Cbx3, and Chromobox 3), and related proteins. HP1gamma is a highly conserved non-histone protein, which is a member of the heterochromatin protein family, and is enriched in the heterochromatin and associated with centromeres. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. In addition to being involved in transcriptional silencing in heterochromatin-like complexes, HP1gamma also binds lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the protein may explain the association of heterochromatin with the inner nuclear membrane. HP1gamma is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. There are three human homologs of HP1 proteins: HP1alpha (also known as Cbx5), HP1beta (also known as Cbx1), and HP1gamma.

Pssm-ID: 349299 Cd Length: 50 Bit Score: 50.39 E-value: 3.21e-09

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 301171613   1 MEYYLvKWKGWPDSTNTWEPLQNLKCPLLLQQFSN 35
Cdd:cd18652   17 VEYFL-KWKGFTDADNTWEPEENLDCPELIEAFLN 50

CD_HP1beta_Cbx1

cd18650

chromodomain of heterochromatin protein 1 homolog beta; CHRomatin Organization Modifier ...

4-33

4.36e-09

chromodomain of heterochromatin protein 1 homolog beta; CHRomatin Organization Modifier (chromo) domain of heterochromatin protein 1 homolog beta (also known as HP1beta, CBX1, and chromobox 1), and related proteins. HP1beta is a highly conserved non-histone protein, which is a member of the heterochromatin protein family, and is enriched in the heterochromatin and associated with centromeres. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. There are three human homologs of HP1 proteins: HP1alpha (also known as Cbx5), HP1beta, and HP1gamma (also known as Cbx3).

Pssm-ID: 349297 Cd Length: 50 Bit Score: 49.94 E-value: 4.36e-09

                         10        20        30
                 ....*....|....*....|....*....|
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLKCPLLLQQF 33
Cdd:cd18650   19 YLLKWKGFSDEDNTWEPEENLDCPDLIAEF 48

chromodomain

cd18968

CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain ...

4-33

4.41e-09

CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain. Chromodomains belong to the chromo-like superfamily of SH3-fold-beta-barrel domains which includes chromo shadow domains and chromo barrel domains. Chromodomains differ from these in that they lack the first strand of the SH3-fold-beta-barrel. This first strand is altered by insertion in the chromo shadow domains, and chromo barrel domains are typical SH3-fold-beta-barrel domains with sequence similarity to the canonical chromo domain.

Pssm-ID: 349324 Cd Length: 57 Bit Score: 50.04 E-value: 4.41e-09

                         10        20        30
                 ....*....|....*....|....*....|.
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLK-CPLLLQQF 33
Cdd:cd18968   25 YLVKWAGYPDEENTWEPEESFDgCDDLLERF 55

CD_HP1alpha_Cbx5

cd18651

chromodomain of heterochromatin protein 1 homolog alpha; CHRomatin Organization Modifier ...

4-33

1.65e-08

chromodomain of heterochromatin protein 1 homolog alpha; CHRomatin Organization Modifier (chromo) domain of heterochromatin protein 1 homolog alpha (also known as HP1alpha, Cbx5, and Chromobox 5), and related proteins. HP1alpha has diverse functions in heterochromatin formation, gene regulation, and mitotic progression, and forms complex networks of gene, RNA, and protein interactions. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. There are three human homologs of HP1 proteins: HP1alpha, HP1beta (also known as Cbx1), and HP1gamma (also known as Cbx3).

Pssm-ID: 349298 Cd Length: 50 Bit Score: 48.45 E-value: 1.65e-08

                         10        20        30
                 ....*....|....*....|....*....|
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLKCPLLLQQF 33
Cdd:cd18651   19 YLLKWKGFSEEHNTWEPEKNLDCPELISEF 48

CD_HP1_like

cd18960

chromodomain of heterochromatin protein 1 proteins, including HP1alpha, HP1beta, and HP1gamma; ...

2-33

1.84e-08

chromodomain of heterochromatin protein 1 proteins, including HP1alpha, HP1beta, and HP1gamma; uncharacterized subgroup; CHRomatin Organization Modifier (chromo) domain of mammalian HP1alpha (Cbx5), HP1beta (Cbx1), HP1gamma (Cbx5), and similar proteins. HP1 has diverse functions in heterochromatin formation and impacts both gene expression and gene silencing. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. There are three human homologs of HP1 proteins: HP1alpha (also known as Cbx5), HP1beta (also known as Cbx1), and HP1gamma (also known as Cbx3).

Pssm-ID: 349316 Cd Length: 51 Bit Score: 48.32 E-value: 1.84e-08

                         10        20        30
                 ....*....|....*....|....*....|..
gi 301171613   2 EYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQF 33
Cdd:cd18960   18 EEFLIKWQGFPESDSSWEPRENLQCDEMLEEF 49

CD_POL_like

cd18974

chromodomain of Penicillium solitum protein PENSOL_c198G03123; This subgroup includes the ...

3-33

1.86e-08

chromodomain of Penicillium solitum protein PENSOL_c198G03123; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in Penicillium solitum protein PENSOL_c198G03123 a putative polyprotein from a Ty3/Gypsy long terminal repeat (LTR) retroelement. The pol gene in TY3/gypsy elements generally encodes domains in the following order: an aspartyl protease, a reverse transcriptase, RNase H, and an integrase, here the chromodomain is found at the C-terminus of the integrase domain. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.

Pssm-ID: 349330 Cd Length: 50 Bit Score: 48.24 E-value: 1.86e-08

                         10        20        30
                 ....*....|....*....|....*....|..
gi 301171613   3 YYLVKWKGWPDSTNTWEPLQNLK-CPLLLQQF 33
Cdd:cd18974   17 HYLVKWKGWPAEYNQWEPEDDMEnAPKAIQSY 48

SET_SMYD

cd20071

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...

82-132

4.28e-08

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.

Pssm-ID: 380997 [Multi-domain] Cd Length: 122 Bit Score: 49.30 E-value: 4.28e-08

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 301171613  82 YGNVSHFvNHSCDPNlqVFNVFIDNldtrlPRIALFSTRTINAGEELTFDY 132
Cdd:cd20071   53 FPLASLL-NHSCDPN--AVVVFDGN-----GTLRVRALRDIKAGEELTISY 95

CHROMO

smart00298

Chromatin organization modifier domain;

4-33

4.51e-08

Chromatin organization modifier domain;

Pssm-ID: 214605 [Multi-domain] Cd Length: 55 Bit Score: 47.21 E-value: 4.51e-08

                           10        20        30
                   ....*....|....*....|....*....|.
gi 301171613     4 YLVKWKGWPDSTNTWEPLQNLK-CPLLLQQF 33
Cdd:smart00298  20 YLVKWKGYSYSEDTWEPEENLLnCSKKLDNY 50

CD_polycomb_like

cd18627

chromodomain of polycomb and chromobox family proteins; CHRomatin Organization Modifier ...

4-35

1.24e-07

chromodomain of polycomb and chromobox family proteins; CHRomatin Organization Modifier (chromo) domain of Polycomb and Polycomb-group (PcG) chromobox (CBX) family proteins such as CBX2, CBX4, CBX6, CBX7, and CBX8. These CBX proteins are components of the PcG repressive complex PRC1, one of the two classes of PRCs. PcG proteins form large multiprotein complexes (PcG bodies) which are involved in the stable repression of genes involved in development, signaling or cancer via chromatin-based epigenetic modifications. Mammalian PRC1 includes canonical (cPRC1) and non-canonical complexes; cPRC1, contains four core subunits including one CBX protein (CBX2, CBX4, and CBX6-CBX8) that binds H3K27me3. CBX family members have different affinity for H3K27me3, with CBX7 having the highest binding capability. The human CBX proteins show distinct nuclear localizations and contribute differently to transcriptional repression. Some CBX proteins of the PRC1 complex have been implicated in transcriptional activation as well as in PRC1-independent roles in embryonic stem cells and in somatic cells.

Pssm-ID: 349277 Cd Length: 49 Bit Score: 46.23 E-value: 1.24e-07

                         10        20        30
                 ....*....|....*....|....*....|..
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSN 35
Cdd:cd18627   18 YLVKWKGWSQKYNTWEPEENILDPRLLAAFES 49

CD_Rhino

cd18630

chromodomain of Drosophila melanogaster Rhino, and similar proteins; N-terminal CHRomatin ...

4-35

1.91e-07

chromodomain of Drosophila melanogaster Rhino, and similar proteins; N-terminal CHRomatin Organization Modifier (chromo) domain of Drosophila melanogaster Rhino (also known as heterochromatin protein 1-like), and similar proteins. Rhino is a female-specific protein that affects chromosome structure and egg polarity that is required for germline PIWI-interacting RNA (piRNA) production. In Drosophila the RDC (rhino, deadlock, and cutoff) complex, composed of rhino, the protein deadlock (Del) and the Rai1-like transcription termination cofactor cutoff (Cuff) binds to chromatin of dual-strand piRNA clusters, special genomic regions, which encode piRNA precursors. The RDC complex is anchored to H3K9me3-marked chromatin in part via the H3K9me3-binding activity of Rhino, and is required for transcription of piRNA precursors. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.

Pssm-ID: 349280 Cd Length: 51 Bit Score: 45.59 E-value: 1.91e-07

                         10        20        30
                 ....*....|....*....|....*....|...
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNL-KCPLLLQQFSN 35
Cdd:cd18630   19 VLVKWSGFPNENNTWEPLENLgNCMKLVADYEA 51

CD_Cbx4

cd18645

chromodomain of chromobox homolog 4; CHRomatin Organization Modifier (chromo) domain of ...

4-35

2.02e-07

chromodomain of chromobox homolog 4; CHRomatin Organization Modifier (chromo) domain of chromobox homolog 4 (CBX4), a component of the PcG repressive complex PRC1, one of the two classes of PRCs. PcG proteins form large multiprotein complexes (PcG bodies) which are involved in the stable repression of genes involved in development, signaling or cancer via chromatin-based epigenetic modifications. Mammalian PRC1 includes canonical (cPRC1) and non-canonical complexes; cPRC1, contains four core subunits including one CBX protein (CBX2, CBX4, and CBX6-CBX8) that binds H3K27me3. CBX family members have different affinity for H3K27me3, with CBX7 having the highest binding capability. The human CBX proteins show distinct nuclear localizations and contribute differently to transcriptional repression. Some CBX proteins of the PRC1 complex have been implicated in transcriptional activation as well as in PRC1-independent roles in embryonic stem cells and in somatic cells. In addition to a chromodomain with H3K27me3-binding activity, Cbx4 contains two SUMO-interacting motifs responsible for its small ubiquitin-related modifier (SUMO) E3 ligase activity. CBX proteins may act as an oncogene or tumor suppressor in a cell-type-dependent manner, for example CBX8 promotes proliferation while suppressing metastasis, in colorectal carcinoma progression. CBX4 may serve as a tumor suppressor in colorectal carcinoma, and has been shown to be an oncogene in osteosarcoma and breast cancer.

Pssm-ID: 349292 Cd Length: 55 Bit Score: 45.82 E-value: 2.02e-07

                         10        20        30
                 ....*....|....*....|....*....|..
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSN 35
Cdd:cd18645   21 YLVKWRGWSPKYNTWEPEENILDPRLLIAFQN 52

CD_MarY1_POL_like

cd18975

chromodomain of Tricholoma matsutake polyprotein, and similar proteins; This subgroup includes ...

4-33

3.03e-07

chromodomain of Tricholoma matsutake polyprotein, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in the polyprotein from the MarY1 Ty3/Gypsy long terminal repeat (LTR) retroelement from the from the Ectomycorrhizal Basidiomycete Tricholoma matsutake. The pol gene in TY3/gypsy elements generally encodes domains in the following order: prt-reverse transcriptase-RNase H-integrase, in marY1 POL the chromodomain is found at the C-terminus of the integrase domain. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.

Pssm-ID: 349331 Cd Length: 49 Bit Score: 45.23 E-value: 3.03e-07

                         10        20        30
                 ....*....|....*....|....*....|
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLKCPLLLQQF 33
Cdd:cd18975   18 YLIQWKGYPLEEASWELEDNIKNPRLIEEF 47

CD_Cbx2

cd18647

chromodomain of chromobox homolog 2; CHRomatin Organization Modifier (chromo) domain of ...

4-34

3.65e-07

chromodomain of chromobox homolog 2; CHRomatin Organization Modifier (chromo) domain of chromobox homolog 2 (CBX2), a component of the PcG repressive complex PRC1, one of the two classes of PRCs. PcG proteins form large multiprotein complexes (PcG bodies) which are involved in the stable repression of genes involved in development, signaling or cancer via chromatin-based epigenetic modifications. Mammalian PRC1 includes canonical (cPRC1) and non-canonical complexes; cPRC1, contains four core subunits including one CBX protein (CBX2, CBX4, and CBX6-CBX8) that binds H3K27me3. CBX family members have different affinity for H3K27me3, with CBX7 having the highest binding capability. The human CBX proteins show distinct nuclear localizations and contribute differently to transcriptional repression. Some CBX proteins of the PRC1 complex have been implicated in transcriptional activation as well as in PRC1-independent roles in embryonic stem cells and in somatic cells.

Pssm-ID: 349294 Cd Length: 53 Bit Score: 45.05 E-value: 3.65e-07

                         10        20        30
                 ....*....|....*....|....*....|.
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLKCPLLLQQFS 34
Cdd:cd18647   21 YLVKWRGWSSKHNSWEPEENILDPRLLLAFQ 51

chromodomain

cd18966

CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain ...

3-32

3.91e-07

Pssm-ID: 349322 Cd Length: 49 Bit Score: 44.58 E-value: 3.91e-07

                         10        20        30
                 ....*....|....*....|....*....|
gi 301171613   3 YYLVKWKGWPDSTNTWEPLQNLKCPLLLQQ 32
Cdd:cd18966   17 RYLVKWEGYPLEEATWEPEENIGDEELLKE 46

CD_polycomb

cd18644

chromodomain of polycomb; CHRomatin Organization Modifier (chromo) domain of the PcG ...

4-24

7.71e-07

chromodomain of polycomb; CHRomatin Organization Modifier (chromo) domain of the PcG (polycomb-group) chromodomain protein Polycomb (Pc) from Drosophila melanogaster, anthropod, worm, and sea cucumber, and similar proteins. Pc is a component of the Polycomb-group (PcG) multiprotein PRC1 complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The core subunits of PRC1 are polycomb (Pc), polyhomeotic (Ph), posterior sex combs (Psc), and sex comb extra (Sce, also known as dRing). Polycomb (Pc) plays a role in modulating life span in flies, it negatively regulates longevity.

Pssm-ID: 349291 Cd Length: 54 Bit Score: 43.99 E-value: 7.71e-07

                         10        20
                 ....*....|....*....|.
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNL 24
Cdd:cd18644   21 YLVKWKGWSNKHNTWEPEENI 41

SET_KMT2E

cd19182

SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar ...

40-132

9.33e-07

SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; KMT2E (also termed inactive lysine N-methyltransferase 2E, myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. It associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Lack of key residues in the SET domain as well as the presence of an unusually large loop in the SET-I subdomain preclude the interaction of MLL5 SET with its cofactor and substrate thus making MLL5 devoid of any in vitro methyltransferase activity on full-length histones and histone H3 peptide.

Pssm-ID: 380959 Cd Length: 129 Bit Score: 45.65 E-value: 9.33e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNldtrLPRIALFST 119
Cdd:cd19182   36 YRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHVIEDG----TIHLYIYSI 111

                         90
                 ....*....|....*..
gi 301171613 120 RTINAGEELT----FDY 132
Cdd:cd19182  112 RSIPKGTEITiafdFDY 128

CD_Chro-like

cd18640

chromodomain of Drosophila melanogaster chromator chromodomain protein, and similar proteins; ...

4-33

1.46e-06

chromodomain of Drosophila melanogaster chromator chromodomain protein, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in chromodomain of Drosophila melanogaster chromator (also known as Chriz/Chro) chromodomain protein, and similar proteins. Chromator is a nuclear protein that plays a role in proper spindle dynamics during mitosis. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.

Pssm-ID: 349290 Cd Length: 52 Bit Score: 43.43 E-value: 1.46e-06

                         10        20        30
                 ....*....|....*....|....*....|.
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNL-KCPLLLQQF 33
Cdd:cd18640   20 YLVKWENRSHHENTWEPMANLeRCKYLLQMF 50

SET_SETD5

cd19181

SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and ...

40-165

1.99e-06

SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. SETD5 loss-of-function mutations are a likely cause of a familial syndromic intellectual disability with variable phenotypic expression.

Pssm-ID: 380958 Cd Length: 150 Bit Score: 45.38 E-value: 1.99e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  40 YLSQVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNldtrLPRIALFST 119
Cdd:cd19181   36 YRGKVMLRQQFEVNGHFFKRPYPFVLFYSKFNGVEMCVDARTFGNDARFIRRSCTPNAEVRHMIADG----MIHLCIYAV 111

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 301171613 120 RTINAGEELT--FDYqmkgsgdissdsiDHSPAKKRVRTVCKCGAVTC 165
Cdd:cd19181  112 AAIAKDAEVTiaFDY-------------EYSNCNYKVDCACHKGNRNC 146

SET_SMYD4

cd10536

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...

88-132

4.39e-06

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.

Pssm-ID: 380934 [Multi-domain] Cd Length: 218 Bit Score: 44.98 E-value: 4.39e-06

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 301171613  88 FVNHSCDPNlqVFNVFIDNLdtrlprIALFSTRTINAGEELTFDY 132
Cdd:cd10536  153 LLNHSCDPN--TIRSFYGNT------IVVRATRPIKKGEEITICY 189

CD_Cbx7

cd18646

chromodomain of chromobox homolog 7; CHRomatin Organization Modifier (chromo) domain of ...

4-30

1.36e-05

chromodomain of chromobox homolog 7; CHRomatin Organization Modifier (chromo) domain of chromobox homolog 7 (CBX7), a component of the PcG repressive complex PRC1, one of the two classes of PRCs. PcG proteins form large multiprotein complexes (PcG bodies) which are involved in the stable repression of genes involved in development, signaling or cancer via chromatin-based epigenetic modifications. Mammalian PRC1 includes canonical (cPRC1) and non-canonical complexes; cPRC1, contains four core subunits including one CBX protein (CBX2, CBX4, and CBX6-CBX8) that binds H3K27me3. CBX family members have different affinity for H3K27me3, with CBX7 having the highest binding capability. The human CBX proteins show distinct nuclear localizations and contribute differently to transcriptional repression. Some CBX proteins of the PRC1 complex have been implicated in transcriptional activation as well as in PRC1-independent roles in embryonic stem cells and in somatic cells. CBX proteins may act as an oncogene or tumor suppressor in a cell-type-dependent manner, for example CBX8 promotes proliferation while suppressing metastasis, in colorectal carcinoma progression. CBX7 has been shown to function as a tumor suppressor in lung carcinoma and an oncogene in gastric cancer and lymphoma.

Pssm-ID: 349293 Cd Length: 56 Bit Score: 40.84 E-value: 1.36e-05

                         10        20
                 ....*....|....*....|....*..
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLKCPLLL 30
Cdd:cd18646   22 YLVKWKGWPPKYSTWEPEEHILDPRLV 48

CD_Cbx8

cd18649

chromodomain of chromobox homolog 8; CHRomatin Organization Modifier (chromo) domain of ...

4-35

2.67e-05

chromodomain of chromobox homolog 8; CHRomatin Organization Modifier (chromo) domain of chromobox homolog 8 (CBX8), a component of the PcG repressive complex PRC1, one of the two classes of PRCs. PcG proteins form large multiprotein complexes (PcG bodies) which are involved in the stable repression of genes involved in development, signaling or cancer via chromatin-based epigenetic modifications. Mammalian PRC1 includes canonical (cPRC1) and non-canonical complexes; cPRC1, contains four core subunits including one CBX protein (CBX2, CBX4, and CBX6-CBX8) that binds H3K27me3. CBX family members have different affinity for H3K27me3, with CBX7 having the highest binding capability. The human CBX proteins show distinct nuclear localizations and contribute differently to transcriptional repression. Some CBX proteins of the PRC1 complex have been implicated in transcriptional activation as well as in PRC1-independent roles in embryonic stem cells and in somatic cells. CBX proteins may act as an oncogene or tumor suppressor in a cell-type-dependent manner, CBX8 for example promotes proliferation while suppressing metastasis, in colorectal carcinoma progression.

Pssm-ID: 349296 Cd Length: 55 Bit Score: 40.09 E-value: 2.67e-05

                         10        20        30
                 ....*....|....*....|....*....|..
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSN 35
Cdd:cd18649   22 YLVKWKGWSQKYSTWEPEENILDARLLAAFEE 53

CD_POL_like

cd18976

chromodomain of uncharacterized putative retroelement polyprotein proteins; This subgroup ...

4-33

2.78e-05

chromodomain of uncharacterized putative retroelement polyprotein proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in uncharacterized putative retrotransposon proteins, and similar proteins. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.

Pssm-ID: 349332 Cd Length: 51 Bit Score: 39.86 E-value: 2.78e-05

                         10        20        30
                 ....*....|....*....|....*....|..
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNL--KCPLLLQQF 33
Cdd:cd18976   18 YLVKWRGFPRSEATWEPREELmrRCAELVAAY 49

CD_POL_like

cd18972

chromodomain of a Moniliophthora perniciosa FA553 putative retrotransposon polyprotein, and ...

4-33

3.85e-05

chromodomain of a Moniliophthora perniciosa FA553 putative retrotransposon polyprotein, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in a Moniliophthora perniciosa FA553 putative retrotelement polyprotein, which includes domains in the following order: a reverse transcriptase, RNase H, and an integrase, here the chromodomain is found at the C-terminus of the integrase domain. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related "chromo shadow" domain

Pssm-ID: 349328 Cd Length: 50 Bit Score: 39.42 E-value: 3.85e-05

                         10        20        30
                 ....*....|....*....|....*....|.
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLK-CPLLLQQF 33
Cdd:cd18972   18 FLVSWLGYDSSHNEWKQKEELEnARELLQDY 48

CD_DDE_transposase_like

cd18978

chromodomain of Rhizopus microsporus putative DDE transposases, and similar proteins; This ...

4-35

4.20e-05

chromodomain of Rhizopus microsporus putative DDE transposases, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in Rhizopus microsporus putative DDE transposases, and similar proteins. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.

Pssm-ID: 349334 Cd Length: 52 Bit Score: 39.22 E-value: 4.20e-05

                         10        20        30
                 ....*....|....*....|....*....|..
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSN 35
Cdd:cd18978   21 YLVKWKGYDDTDNSWVTQEDFNDKDMIDEYEN 52

CD_Tf2-1_POL_like

cd18973

chromodomain of Rhizoctonia solani AG-1 IB retrotransposable element Tf2 155 kDa protein type ...

4-25

5.86e-05

chromodomain of Rhizoctonia solani AG-1 IB retrotransposable element Tf2 155 kDa protein type 1, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in Rhizoctonia solani AG-1 IB retrotransposable element Tf2 155 kDa protein type 1 (Tf2-1), and similar proteins. It belongs to the Ty3/gypsy family of long terminal repeat (LTR) retrotransposons. The pol gene in TY3/gypsy elements generally encodes domains in the following order: an aspartyl protease, a reverse transcriptase, RNase H, and an integrase, here the chromodomain is found at the C-terminus of the integrase domain. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.

Pssm-ID: 349329 Cd Length: 50 Bit Score: 39.15 E-value: 5.86e-05

                         10        20
                 ....*....|....*....|..
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLK 25
Cdd:cd18973   18 YLVKWKGYGPEHNTWEPRENLE 39

chromodomain

cd18965

CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain ...

4-25

6.62e-05

Pssm-ID: 349321 Cd Length: 53 Bit Score: 39.00 E-value: 6.62e-05

                         10        20
                 ....*....|....*....|..
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLK 25
Cdd:cd18965   18 YLVKWHGLPESENTWEREKDIK 39

CD_CMT3_like

cd18635

chromodomain of chromomethylase 3, and similar proteins; CHRomatin Organization Modifier ...

3-33

7.84e-05

chromodomain of chromomethylase 3, and similar proteins; CHRomatin Organization Modifier (chromo) domain of DNA (cytosine-5)-methyltransferase chromomethylase 3 (CMT3, EC:2.1.1.37), and similar proteins. CMT3 is primarily a CHG (where H is either A, T or C) methyltransferase and is predominantly expressed in actively replicating cells. The protein is involved in preferentially methylating transposon-related sequences, reducing their mobility. Studies suggest that in order to target DNA methylation, CMT3 associates with H3K9me2-containing nucleosomes through binding of its BAH- and chromo-domains to H3K9me2. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.

Pssm-ID: 349285 Cd Length: 57 Bit Score: 38.83 E-value: 7.84e-05

                         10        20        30
                 ....*....|....*....|....*....|..
gi 301171613   3 YYLVKWKGWPDSTNTWEPLQNL-KCPLLLQQF 33
Cdd:cd18635   24 YFKVRWKGYGPEEDTWEPIEGLsNCPEKIKEF 55

CD_POL_like

cd18971

chromodomain of a Magnaporthe grisea putative retrotransposon polyprotein, and similar ...

4-25

7.98e-05

chromodomain of a Magnaporthe grisea putative retrotransposon polyprotein, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in a Magnaporthe grisea putative retrotransposon polyprotein which includes domains in the following order: an aspartyl protease, a reverse transcriptase, RNase H, and an integrase, here the chromodomain is found at the C-terminus of the integrase domain. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.

Pssm-ID: 349327 Cd Length: 50 Bit Score: 38.53 E-value: 7.98e-05

                         10        20
                 ....*....|....*....|..
gi 301171613   4 YLVKWKGWPDStnTWEPLQNLK 25
Cdd:cd18971   21 VLVKWVGYAEP--TWEPLDNLA 40

CD_MT_like

cd18962

chromodomain of a putative Coemansia reversa NRRL 1564 methyltransferase, and similar proteins; ...

4-33

9.44e-05

chromodomain of a putative Coemansia reversa NRRL 1564 methyltransferase, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in a Coemansia reversa NRRL 1564 SET (Su(var)3-9, enhancer-of-zeste, trithorax) domain-containing protein, and similar proteins. The SU(VAR)3-9 protein is the main chromocenter-specific histone H3-K9 methyltransferase (HMTase) in Drosophila where it plays a role in heterochromatic gene silencing. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.

Pssm-ID: 349318 Cd Length: 52 Bit Score: 38.32 E-value: 9.44e-05

                         10        20        30
                 ....*....|....*....|....*....|
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLKCPLLLQQF 33
Cdd:cd18962   21 YEVKWEGYPSDHNNWVAEWDLNDKEILRKY 50

chromodomain

cd18964

CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain ...

4-33

1.17e-04

Pssm-ID: 349320 Cd Length: 54 Bit Score: 38.08 E-value: 1.17e-04

                         10        20        30
                 ....*....|....*....|....*....|.
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNL-KCPLLLQQF 33
Cdd:cd18964   22 WLVKWDGYPIEDATWEPPENLgEHAKLIEDF 52

CD_Clr4_like

cd18632

N-terminal chromodomain of the fission yeast histone methyltransferase Clr4, and similar ...

4-37

1.23e-04

N-terminal chromodomain of the fission yeast histone methyltransferase Clr4, and similar proteins; N-terminal CHRomatin Organization Modifier (chromo) domain of cryptic loci regulator 4 (Clr4), a histone H3 lysine methyltransferase which targets H3K9. Clr4 regulates silencing and switching at the mating-type loci and affects chromatin structure at centromeres. Clr4 is a catalytic component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.

Pssm-ID: 349282 Cd Length: 55 Bit Score: 38.26 E-value: 1.23e-04

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLK-CPLLLQQFSNDK 37
Cdd:cd18632   21 YLVRWKNYSKNHDTWEPAENLSgCQAVLEKWKRKK 55

SET_SpSet7-like

cd10540

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...

63-132

1.49e-04

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).

Pssm-ID: 380938 Cd Length: 112 Bit Score: 39.16 E-value: 1.49e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 301171613  63 TYLFDLDYE-SDEFTVDAARYGnvSHFvNHSCDPNLQVfnvfidNLDTRLPRIALFSTRTINAGEELTFDY 132
Cdd:cd10540   45 TVLDHYVFSwGDGCLALALGYG--SMF-NHSYTPNAEY------EIDFENQTIVFYALRDIEAGEELTINY 106

CD_Cbx6

cd18648

chromodomain of chromobox homolog 6; CHRomatin Organization Modifier (chromo) domain of ...

4-33

1.50e-04

chromodomain of chromobox homolog 6; CHRomatin Organization Modifier (chromo) domain of chromobox homolog 6 (CBX6), a component of the PcG repressive complex PRC1, one of the two classes of PRCs. PcG proteins form large multiprotein complexes (PcG bodies) which are involved in the stable repression of genes involved in development, signaling or cancer via chromatin-based epigenetic modifications. Mammalian PRC1 includes canonical (cPRC1) and non-canonical complexes; cPRC1, contains four core subunits including one CBX protein (CBX2, CBX4, and CBX6-CBX8) that binds H3K27me3. CBX family members have different affinity for H3K27me3, with CBX7 having the highest binding capability. The human CBX proteins show distinct nuclear localizations and contribute differently to transcriptional repression. Some CBX proteins of the PRC1 complex have been implicated in transcriptional activation as well as in PRC1-independent roles in embryonic stem cells and in somatic cells.

Pssm-ID: 349295 Cd Length: 58 Bit Score: 38.11 E-value: 1.50e-04

                         10        20        30
                 ....*....|....*....|....*....|
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLKCPLLLQQF 33
Cdd:cd18648   21 YLVKWKGWAIKYSTWEPEENILDSRLIAAF 50

SET_Suv4-20-like

cd10524

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...

88-166

2.98e-04

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.

Pssm-ID: 380922 [Multi-domain] Cd Length: 141 Bit Score: 38.80 E-value: 2.98e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 301171613  88 FVNHSCDPNLQVFNvfidnldTRLPRIALFSTRTINAGEELTFDYQMKGSGDISSDsidhspakkrvrtvCKCgaVTCR 166
Cdd:cd10524   79 FINHDCRPNCKFVP-------TGKSTACVKVLRDIEPGEEITVYYGDNYFGENNEE--------------CEC--ETCE 134

CD1_tandem_CHD1-2_like

cd18666

repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 1 and ...

4-25

3.84e-04

repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 1 and 2, and similar proteins; Repeat 1 of tandem CHRomatin Organization Modifier (chromo) domains, found in CHD (chromodomain helicase DNA-binding) proteins such as mammalian helicase DNA-binding proteins CHD1 and CHD2. The CHD proteins belong to the SNF2 superfamily of ATP-dependent chromatin remodelers and contain two signature motifs: a pair of chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein. CHD chromatin remodelers are important regulators of transcription and play critical roles during developmental processes. The N-terminal chromodomains of CHD1 have been shown to guard against sliding hexasomes. Mutations in the chromodomains of mouse CHD1 result in nuclear redistribution, suggesting that the chromodomain is essential for proper association with chromatin; also, deletion of the chromodomains in the Drosophila melanogaster CHD3-4 homolog impaired nucleosome binding, mobilization, and ATPase functions. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.

Pssm-ID: 349313 Cd Length: 85 Bit Score: 37.66 E-value: 3.84e-04

                         10        20
                 ....*....|....*....|..
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLK 25
Cdd:cd18666   49 YLIKWKGWSHIHNTWESEESLK 70

CD_NC-like

cd18980

chromodomain of a Tasahii var. asahii CBS 8904 retrotransposon nucleocapsid protein, and ...

2-24

6.93e-04

chromodomain of a Tasahii var. asahii CBS 8904 retrotransposon nucleocapsid protein, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in Trichosporon asahii var. asahii CBS 8904 retrotransposon nucleocapsid protein, and similar proteins. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.

Pssm-ID: 349336 Cd Length: 56 Bit Score: 36.40 E-value: 6.93e-04

                         10        20
                 ....*....|....*....|...
gi 301171613   2 EYYLVKWKGWPDSTNTWEPLQNL 24
Cdd:cd18980   22 NFYLVRWRGYGPSHDSWEPTSAL 44

SET_SMYD3

cd19203

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 ...

82-132

7.42e-04

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins; SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers.

Pssm-ID: 380980 [Multi-domain] Cd Length: 210 Bit Score: 38.50 E-value: 7.42e-04

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 301171613  82 YGNVSHFvNHSCDPN-LQVFNVFidnldtrlpRIALFSTRTINAGEELTFDY 132
Cdd:cd19203  140 YPSASLL-NHSCDPNcVIVFNGP---------HLLLRAIREIEVGEELTISY 181

CD_EhHp1_like

cd18638

chromodomain of Entamoeba histolytica heterochromatin protein 1, and similar proteins; This ...

4-33

9.47e-04

chromodomain of Entamoeba histolytica heterochromatin protein 1, and similar proteins; This subgroup includes the N-terminal CHRomatin Organization Modifier (chromo) domain of heterochromatin protein 1 (HP1)-like protein from Entamoeba histolytica, and similar proteins. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.

Pssm-ID: 349288 Cd Length: 52 Bit Score: 35.70 E-value: 9.47e-04

                         10        20        30
                 ....*....|....*....|....*....|..
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLK--CPLLLQQF 33
Cdd:cd18638   19 YFVKWKGYSAKENTWETEDNLEksYKEMIDEF 50

CD_CDY

cd18634

chromodomain of the Chromodomain Y-like protein family; This group includes the chromodomain ...

4-25

2.49e-03

chromodomain of the Chromodomain Y-like protein family; This group includes the chromodomain found in the mammalian chromodomain Y-like (CDY) protein family, and similar proteins. The human CDY family includes 6 proteins: the genes encoding four of these: two copies of CDY1 (CDY1a, CDY1a) and two copies of CDY2(CDY2a and CDY2b), are located on chromosome Y, and the genes encoding the other two members (CDYL and CDYL2) are located on autosomes. The chromosomal genes are only present in primates, whereas the CDYL and CDYL2 genes exist in most mammalian species. The CDY family proteins contain two functional domains: a chromodomain involved in chromatin binding and a catalytic domain found in many coenzyme A (CoA)- dependent acylation enzymes. CDYL is ubiquitously expressed, whereas CDYL2 shows selective expression in tissues of testis, prostate, spleen, and leukocyte. The CDYL genes are ubiquitously expressed, the CDY genes are only expressed in the testis. Deletion of the CDY1b gene has been shown to be a risk factor for male infertility. Impairments in CDY2 expression could be implicated in the pathogenesis of maturation arrest (a failure of germ cell development).

Pssm-ID: 349284 Cd Length: 52 Bit Score: 34.73 E-value: 2.49e-03

                         10        20
                 ....*....|....*....|..
gi 301171613   4 YLVKWKGWPDSTNTWEPLQNLK 25
Cdd:cd18634   20 YLVRWKGYDSEDDTWEPEQHLL 41

SET_ATXR5_6-like

cd10539

SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The ...

55-132

3.41e-03

SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The family includes Arabidopsis thaliana ATXR5 and ATXR6. Both ATXR5 (also termed protein SET DOMAIN GROUP 15, or TRX-related protein 5) and ATXR6 (also termed protein SET DOMAIN GROUP 34, or TRX-related protein 6) function as histone methyltransferase that specifically monomethylates 'Lys-37' of histone H3 (H3K27me1). They are required for chromatin structure and gene silencing.

Pssm-ID: 380937 Cd Length: 138 Bit Score: 35.85 E-value: 3.41e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301171613  55 QFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFV----NHSCD----PNLQVFNVFIDNldtrLPRIALFSTRTINAGE 126
Cdd:cd10539   44 EFDDNDSIMTLLLAGDPSKSLVICPDKRGNIARFIsginNHTKDgkkkQNCKCVRYSING----EARVLLVATRDIAKGE 119


                 ....*.
gi 301171613 127 ELTFDY 132
Cdd:cd10539  120 RLYYDY 125

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01