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Conserved domains on  [gi|300797489|ref|NP_001180047|]
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zinc finger protein 652 [Bos taurus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
457-480 9.41e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 9.41e-05
                          10        20
                  ....*....|....*....|....
gi 300797489  457 NMKRHRRTHTGEKPYPCDVCGQRF 480
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
441-490 1.48e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.48e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 300797489 441 KPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHK 490
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSR 81
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 383-466 1.04e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797489 383 GEKPFRCE--NCDERFQYKYQLRSHMsIHiGHkqfmcqwCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKR 460
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH-GH-------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 300797489 461 HRRTHT 466
Cdd:COG5189  417 HRKHSH 422
PLN03086 super family cl29366
PRLI-interacting factor K; Provisional
 242-306 2.22e-03

PRLI-interacting factor K; Provisional


The actual alignment was detected with superfamily member PLN03086:

Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 41.01  E-value: 2.22e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300797489 242 EEKETLTCEKCPRVFNTRwYLEKHMNVTHRRMQicdkCGKKFVLESELSL-HQQTDCE-KNIQCVSC 306
Cdd:PLN03086 449 EAKNHVHCEKCGQAFQQG-EMEKHMKVFHEPLQ----CPCGVVLEKEQMVqHQASTCPlRLITCRFC 510
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 499-547 4.09e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 4.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 300797489  499 PVNVPPAVQIPLTTSPATPVPSAVNTPTTPAPPVSMNPVGTLPPRPiPH 547
Cdd:pfam03154 181 ASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAA-PH 228
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
457-480 9.41e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 9.41e-05
                          10        20
                  ....*....|....*....|....
gi 300797489  457 NMKRHRRTHTGEKPYPCDVCGQRF 480
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
441-490 1.48e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.48e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 300797489 441 KPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHK 490
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSR 81
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 383-466 1.04e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797489 383 GEKPFRCE--NCDERFQYKYQLRSHMsIHiGHkqfmcqwCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKR 460
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH-GH-------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 300797489 461 HRRTHT 466
Cdd:COG5189  417 HRKHSH 422
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 443-465 1.16e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|...
gi 300797489  443 FICEICGKSFTSRPNMKRHRRTH 465
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 242-306 2.22e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 41.01  E-value: 2.22e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300797489 242 EEKETLTCEKCPRVFNTRwYLEKHMNVTHRRMQicdkCGKKFVLESELSL-HQQTDCE-KNIQCVSC 306
Cdd:PLN03086 449 EAKNHVHCEKCGQAFQQG-EMEKHMKVFHEPLQ----CPCGVVLEKEQMVqHQASTCPlRLITCRFC 510
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 499-547 4.09e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 4.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 300797489  499 PVNVPPAVQIPLTTSPATPVPSAVNTPTTPAPPVSMNPVGTLPPRPiPH 547
Cdd:pfam03154 181 ASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAA-PH 228
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
252-461 5.65e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 5.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797489 252 CPRVFNTRWYLEKHMNVTHRRMQICDKCGKKFVLESELSlHQQTD------CEKNIQCVSCNKSF--KKLWSLHEHIKIV 323
Cdd:COG5048  236 SPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSS-PNESDsssekgFSLPIKSKQCNISFsrSSPLTRHLRSVNH 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797489 324 HGYAEKKFSC--EICEKKFYTMAHVRKHMVAHTKDMPFTCETCGKSFKRS-------------MSLKVHSLQHSGEKPFR 388
Cdd:COG5048  315 SGESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSpllnneppqslqqYKDLKNDKKSETLSNSC 394

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300797489 389 CENCDERFQYKYQLRSHMSIhiGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFtSRPNMKRH 461
Cdd:COG5048  395 IRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR-RDLDLSNH 464
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
457-480 9.41e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 9.41e-05
                          10        20
                  ....*....|....*....|....
gi 300797489  457 NMKRHRRTHTGEKPYPCDVCGQRF 480
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
441-490 1.48e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.48e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 300797489 441 KPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHK 490
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSR 81
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 439-490 4.00e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 4.00e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300797489 439 GEKPFICEI--CGKSFTSRPNMKRHR-------RTH------------TGEKPYPCDVCGQRFRFSNMLKAHK 490
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMlhghqnqKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 383-466 1.04e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797489 383 GEKPFRCE--NCDERFQYKYQLRSHMsIHiGHkqfmcqwCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKR 460
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH-GH-------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 300797489 461 HRRTHT 466
Cdd:COG5189  417 HRKHSH 422
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 443-465 1.16e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|...
gi 300797489  443 FICEICGKSFTSRPNMKRHRRTH 465
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
429-454 1.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.20e-03
                          10        20
                  ....*....|....*....|....*.
gi 300797489  429 YFDEHMKTHTGEKPFICEICGKSFTS 454
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 242-306 2.22e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 41.01  E-value: 2.22e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300797489 242 EEKETLTCEKCPRVFNTRwYLEKHMNVTHRRMQicdkCGKKFVLESELSL-HQQTDCE-KNIQCVSC 306
Cdd:PLN03086 449 EAKNHVHCEKCGQAFQQG-EMEKHMKVFHEPLQ----CPCGVVLEKEQMVqHQASTCPlRLITCRFC 510
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 499-547 4.09e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 4.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 300797489  499 PVNVPPAVQIPLTTSPATPVPSAVNTPTTPAPPVSMNPVGTLPPRPiPH 547
Cdd:pfam03154 181 ASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAA-PH 228
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
252-461 5.65e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 5.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797489 252 CPRVFNTRWYLEKHMNVTHRRMQICDKCGKKFVLESELSlHQQTD------CEKNIQCVSCNKSF--KKLWSLHEHIKIV 323
Cdd:COG5048  236 SPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSS-PNESDsssekgFSLPIKSKQCNISFsrSSPLTRHLRSVNH 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300797489 324 HGYAEKKFSC--EICEKKFYTMAHVRKHMVAHTKDMPFTCETCGKSFKRS-------------MSLKVHSLQHSGEKPFR 388
Cdd:COG5048  315 SGESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSpllnneppqslqqYKDLKNDKKSETLSNSC 394

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300797489 389 CENCDERFQYKYQLRSHMSIhiGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFtSRPNMKRH 461
Cdd:COG5048  395 IRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR-RDLDLSNH 464
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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