|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02414 |
PLN02414 |
glycine dehydrogenase (decarboxylating) |
51-1009 |
0e+00 |
|
glycine dehydrogenase (decarboxylating)
Pssm-ID: 178035 [Multi-domain] Cd Length: 993 Bit Score: 1488.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 51 RLLERLLPRH------------DDFARRHIGPGDKDQKEMLQALGLASVDELIEKTIPASIRlKRPLKM---DDPVCENE 115
Cdd:PLN02414 11 GLLRRLVNEQtrsisvealkpsDTFPRRHNSATPEEQKAMAEYCGFDSLDALIDATVPKSIR-LDSMKLskyDEGLTESQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 116 ILATLHAISNKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANAS 195
Cdd:PLN02414 90 MLEHMKSLASKNKVFKSYIGMGYYNTHVPPVILRNILENPGWYTQYTPYQAEIAQGRLESLLNYQTMITDLTGLPMSNAS 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 196 LLDEATAAAEAMQLCHRQNKRRK--FFVDPRCHPQTIAVVQTRAKYSGVLIELKLPHEMDFSSKDVSGVLFQYPDTEGKV 273
Cdd:PLN02414 170 LLDEGTAAAEAMAMCNNILKGKKkkFLIASNCHPQTIDVCQTRADGLGLEVVVADEKDFDYSSGDVCGVLVQYPATDGEV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 274 EDFTELVERAHEAGSLACCATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRENLVRMMPGRMVGVTR 353
Cdd:PLN02414 250 LDYAEFVKNAHANGVKVVMATDLLALTMLKPPGEWGADIVVGSAQRFGVPMGYGGPHAAFLATSQEYKRLMPGRIIGVSV 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 354 DVSGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAVMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQHDL 433
Cdd:PLN02414 330 DSSGKPALRMAMQTREQHIRRDKATSNICTAQALLANMAAMYAVYHGPEGLKTIAQRVHGLAGVFAAGLKKLGFQVQSLP 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 434 FFDTLKIQCGcSVKEVLGRAAQRQINIRLFEDGTLGISLDETVNEKDLDDLLWIFGCESSAELVAESMGEERRGILGTAF 513
Cdd:PLN02414 410 FFDTVKVKCS-DADAIADAAAKVGINLRVVDANTVTVSFDETTTLEDVDKLFKVFAGGKPVPFTAESLAPEVDSSIPSSL 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 514 KRTSPFLTHQVFNSYHSETNIVRYMKRLENKDISLVHSMIPLGSCTMKLNSSSELTPITWKEFANIHPFVPLDQAQGYQQ 593
Cdd:PLN02414 489 ARESPYLTHPIFNQYHSEHELLRYLHRLQNKDLSLVHSMIPLGSCTMKLNATTEMMPVTWPEFANIHPFAPVDQAQGYQE 568
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 594 LFRELEKDLCELTGYDRISFQPNSGAQGEYAGLASIRAYLDAKGETHRTVCLIPKSAHGTNPASAHMAGMRIQPVEVDKY 673
Cdd:PLN02414 569 MFEDLGDLLCEITGFDSFSLQPNAGAAGEYAGLMVIRAYHLSRGDHHRNVCIIPVSAHGTNPASAAMCGMKIVVVGTDAK 648
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 674 GNIDAAHLKAMVDKHKENLAAIMITYPSTNGVFEENIGDVCDLIHLHGGQVYLDGANMNAQVGLCRPGDFGSDVSHLNLH 753
Cdd:PLN02414 649 GNINIEELRKAAEAHKDNLAALMVTYPSTHGVYEEGIDEICDIIHDNGGQVYMDGANMNAQVGLTSPGFIGADVCHLNLH 728
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 754 KTFCIPHGGGGPGMGPIGVKKHLVPFLPNHPII---SLKPSEDAQALGTVSAAPWGSSCILPISWAYIKMMGGKGLKQAT 830
Cdd:PLN02414 729 KTFCIPHGGGGPGMGPIGVKKHLAPFLPSHPVVptgGIPRPEKTQPLGTISAAPWGSALILPISYTYIAMMGSEGLTDAS 808
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 831 EIAILNANYMAKRLEKHYRVLFRGARGYVAHEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWPVAGTLMIEPTES 910
Cdd:PLN02414 809 KIAILNANYMAKRLEGHYPVLFRGKNGTCAHEFIIDLRPFKNTAGIEPEDVAKRLMDYGFHAPTMSWPVPGTLMIEPTES 888
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 911 EDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSHWDRPYSREVAAFPLPFVKpENKFWPTISRID 990
Cdd:PLN02414 889 ESKAELDRFCDALISIREEIADIENGKADRENNVLKGAPHPPSLLMADKWDKPYSREYAAFPAPWVR-ASKFWPTTGRVD 967
|
970
....*....|....*....
gi 300794105 991 DIYGDQHLVCTCPPMDVYE 1009
Cdd:PLN02414 968 NVYGDRNLVCTLPSAAEEE 986
|
|
| gcvP |
TIGR00461 |
glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in ... |
66-1002 |
0e+00 |
|
glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in bacterial, mammalian and plant sources. The enzyme catalyzes the reaction: GLYCINE + LIPOYLPROTEIN = S-AMINOMETHYL-DIHYDROLIPOYLPROTEIN + CO2. It is part of the glycine decarboxylase multienzyme complex (GDC) consisting of four proteins P, H, L and T. Active site in E.coli is located as the (K) residues at position 713 of the SEED alignment. [Energy metabolism, Amino acids and amines]
Pssm-ID: 273089 [Multi-domain] Cd Length: 939 Bit Score: 1304.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 66 RHIGPGDKDQKEMLQALGLASVDELIEKTIPASIRLKRPLKMDDPVCENEILATLHAISNKNQIWRSYIGMGYYNCSVPQ 145
Cdd:TIGR00461 1 RHLGPGETEQRQMLQTLGFDTLNALIDQAVPPAIRFPRPLQLPAPQSEYGALAQLKSIASKNQVFRSYIGMGYYDTILPP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 146 TILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANASLLDEATAAAEAMQLCHR--QNKRRKFFVDP 223
Cdd:TIGR00461 81 VIQRNILENPGWYTAYTPYQPEISQGRLEALLNFQTVVMDLTGLEIANASLLDEGTAAAEAMALSYGvsKSKANAFFVAQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 224 RCHPQTIAVVQTRAKYSGVLIELKLPHEMDFSSkDVSGVLFQYPDTEGKVEDFTELVERAHEAGSLACCATDLLALCILR 303
Cdd:TIGR00461 161 DCHPQTIEVIKTRANPFGIEVIVGDHHTFSFST-DVFGALLQYPATDGAIYDYRSLIDKLHSHKALVSVAADPMALTLLT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 304 PPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRENLVRMMPGRMVGVTRDVSGKEVYRLALQTREQHIRRDKATSNICT 383
Cdd:TIGR00461 240 PPGELGADIVVGSTQRFGVPMGYGGPHAAFFATKDEYQRKMPGRIVGVSKDAHGNTALRLALQTREQHIRRDKATSNICT 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 384 AQALLANMAVMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQHDLFFDTLKIQCG-CSVKEVLGRAAQRQINIRL 462
Cdd:TIGR00461 320 AQVLLANMASMYGVYHGPTGLKNIALRIHQLTVILAIGLKRLNYSLNNDYFFDTLRVGVGeQSAPAILKAAEGRGINLRP 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 463 FEDGTLGISLDETVNEKDLDDLLWIFGCESSAELVAESMGEERRGILGTAFKRTSPFLTHQVFNSYHSETNIVRYMKRLE 542
Cdd:TIGR00461 400 LVPGEVGISLDETTTVQDVLDLWQVFAGKDNLPFTPEELWSDVKTSFPADLTRQDEILQDAVFNQYHSETEMLRYLHQLE 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 543 NKDISLVHSMIPLGSCTMKLNSSSELTPITWKEFANIHPFVPLDQAQGYQQLFRELEKDLCELTGYDRISFQPNSGAQGE 622
Cdd:TIGR00461 480 SKDLALNTSMIPLGSCTMKLNATAEMMPITWPEFGKIHPFAPAGQTEGYQILIAQLEAWLGEITGFDAISLQPNSGAQGE 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 623 YAGLASIRAYLDAKGETHRTVCLIPKSAHGTNPASAHMAGMRIQPVEVDKYGNIDAAHLKAMVDKHKENLAAIMITYPST 702
Cdd:TIGR00461 560 YAGLQVIRQYHESRGEEHRNICLIPESAHGTNPASAVMAGMQVVPVKCDGEGNIDLEDLTSKAEQYGDRLAALMVTYPST 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 703 NGVFEENIGDVCDLIHLHGGQVYLDGANMNAQVGLCRPGDFGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLVPFLPN 782
Cdd:TIGR00461 640 HGVFEATIGTICDIVHRFGGQVYLDGANMNAQVGLTSPGDFGADVCHLNLHKTFCIPHGGGGPGMGPIGVKSHLQPFLPR 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 783 HPIISLKPSE-DAQALGTVSAAPWGSSCILPISWAYIKMMGGKGLKQATEIAILNANYMAKRLEKHYRVLFRGARGYVAH 861
Cdd:TIGR00461 720 HSLNSTAELQgEDQSIGMVSAAPYGSASILPISWMYIAMMGPEGLTKASEVAILNANYMAKRLEDYYPILFRGNNELVAH 799
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 862 EFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWPVAGTLMIEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDPR 941
Cdd:TIGR00461 800 ECILDLRPLKKQAGIEVEDVAKRLMDYGFHAPTVSFPVLGTLMVEPTESESLGELDRFCDAMIAIYQEIQAITAGEIDPA 879
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 300794105 942 VNPLKMSPHSLTCVTSSHWDRPYSREVAAFPLPFVKpENKFWPTISRIDDIYGDQHLVCTC 1002
Cdd:TIGR00461 880 DNPLKNAPHTAQSLICGEWNHPYSREEAAYPAPWTK-QFKFWPTVGRLDDTYGDRNLVCSC 939
|
|
| GDC-P |
pfam02347 |
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ... |
65-488 |
0e+00 |
|
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
Pssm-ID: 396772 [Multi-domain] Cd Length: 428 Bit Score: 764.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 65 RRHIGPGDKDQKEMLQALGLASVDELIEKTIPASIRLKRPLKMDDPVCENEILATLHAISNKNQIWRSYIGMGYYNCSVP 144
Cdd:pfam02347 1 DRHIGPSEKDQQEMLATLGYSSLDDLIGKAVPKNIRFAKPLQLPAPKSEYEALAELEAIASKNTVYRSFIGMGYYDTILP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 145 QTILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANASLLDEATAAAEAMQLCHRQNKRR--KFFVD 222
Cdd:pfam02347 81 PVILRNILENPEWYTAYTPYQPEISQGRLEALLNFQTMICDLTGLDIANASLLDEGTAAAEAMALAARASKKKgkKFVVD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 223 PRCHPQTIAVVQTRAKYSGVLIELKLPHEMDFS-SKDVSGVLFQYPDTEGKVEDFTELVERAHEAGSLACCATDLLALCI 301
Cdd:pfam02347 161 KDVHPQTLEVLKTRAKPFGIEIVEVDYTEEGVTdLKDVFGVLVQYPNTDGRIEDYKELIELAHQRKSLVVVAADLLALTL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 302 LRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRENLVRMMPGRMVGVTRDVSGKEVYRLALQTREQHIRRDKATSNI 381
Cdd:pfam02347 241 LKPPGEFGADIAVGSAQRFGVPLGYGGPHAGFFAVKKELVRKMPGRLVGVSKDANGKRALRLALQTREQHIRRDKATSNI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 382 CTAQALLANMAVMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQHDLFFDTLKIQCG-CSVKEVLGRAAQRQINI 460
Cdd:pfam02347 321 CTAQALLANMASMYAVYHGPNGLKEIARRIHSLTLYLAKALKKLGHELVHKHFFDTLLIEVEdKAVEEVLARAEARGINL 400
|
410 420
....*....|....*....|....*...
gi 300794105 461 RLFEDGTLGISLDETVNEKDLDDLLWIF 488
Cdd:pfam02347 401 RYVDLGHVGIALDETVTKEDIDDLLQVF 428
|
|
| GcvP2 |
COG1003 |
Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport ... |
509-1001 |
0e+00 |
|
Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440627 Cd Length: 468 Bit Score: 734.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 509 LGTAFKRTSPflthqVFNSYHSETNIVRYMKRLENKDISLVHSMIPLGSCTMKLNSSSELTPITWKEFANIHPFVPLDQA 588
Cdd:COG1003 14 LPEALLRKSP-----VFLPEVSETEVLRHYTRLSQKNLGLDTGMIPLGSCTMKYNPKINEEPATLPGFANLHPFQPEETV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 589 QGYQQLFRELEKDLCELTGYDRISFQPNSGAQGEYAGLASIRAYLDAKGETHRTVCLIPKSAHGTNPASAHMAGMRIQPV 668
Cdd:COG1003 89 QGYLELMYELEEWLAEITGMDAVSLQPNAGAQGEYAGLLAIRAYHESRGEGHRNEILIPDSAHGTNPASAAMAGFKVVVV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 669 EVDKYGNIDAAHLKAMVDkhkENLAAIMITYPSTNGVFEENIGDVCDLIHLHGGQVYLDGANMNAQVGLCRPGDFGSDVS 748
Cdd:COG1003 169 KSDEDGNVDLEDLKAKVG---DRTAALMLTNPSTHGVFEEDIKEICDIVHEAGGLVYYDGANLNAIVGLARPGDMGFDVC 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 749 HLNLHKTFCIphggggpgmgpigVKKHLVPFLPNHPII----SLKPSEDAQALGTVSAAPWGSSCILPISWAYIKMMGGK 824
Cdd:COG1003 246 HLNLHKTFSTphggggpgsgpvgVKEHLAPFLPGPPVVkdgdKYRLDYDRPKSIGRSAAFYGNAGVLVRAYAYIRMMGAE 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 825 GLKQATEIAILNANYMAKRLEKHYRVLFRGaRGYVAHEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWP--VAGT 902
Cdd:COG1003 326 GLREATEVAVLNANYLAARLKDHYPVLYTG-NGRCAHEFILDLRPLKKETGVTTLDIAKRLLDYGFHAPTMYFPliVPET 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 903 LMIEPTESEDKAELDRFCDAMISIRQEIADieegriDPrvNPLKMSPHSLtcvtsshwdrpysrevaafplpfvkpenkf 982
Cdd:COG1003 405 LMIEPTESESKEELDRFIDAMIAIREEARE------DP--EPLKNAPHTT------------------------------ 446
|
490
....*....|....*....
gi 300794105 983 wpTISRIDDIYGDQHLVCT 1001
Cdd:COG1003 447 --PVRRLDEVYADRNLVLT 463
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
113-488 |
7.24e-175 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 515.63 E-value: 7.24e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 113 ENEILATLHAISNKNQIWR---SYIGMGYYNCSVPQTILRNLLENsGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGL 189
Cdd:cd00613 1 ETEVLRHLKRLASKNKALDqsmSFLGSGTYKHNPPAVIKRNILEN-EFYTAYTPYQPEISQGRLQALFELQTMLCELTGM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 190 DMANASLLDEATAAAEAMQLCHRQNK--RRKFFVDPRCHPQTIAVVQTRAKYSGVLIELKLPHEM---------DFSSKD 258
Cdd:cd00613 80 DVANASLQDEATAAAEAAGLAAIRAYhkRNKVLVPDSAHPTNPAVARTRGEPLGIEVVEVPSDEGgtvdlealkEEVSEE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 259 VSGVLFQYPDTEGKVEDF-TELVERAHEAGSLACCATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVR 337
Cdd:cd00613 160 VAALMVQYPNTLGVFEDLiKEIADIAHSAGALVYVDGDNLNLTGLKPPGEYGADIVVGNLQKTGVPHGGGGPGAGFFAVK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 338 ENLVRMMPGRMVGVTRDVSGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAVMFAIYHGSHGLEHIARRVHNATLI 417
Cdd:cd00613 240 KELVRFLPGRLVGVTKDAEGNRAFRLALQTREQHIRREKATSNICTGQALLALMAAMYIVYLGPEGLKEIAERAHLNANY 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300794105 418 LSEGLKRAGHQLQ-HDLFFDTLKIQCGC---SVKEVLGRAAQRQINIR----LFEDGTLGISLDETVNEKDLDDLLWIF 488
Cdd:cd00613 320 LAKRLKEVGGVLPfNGPFFHEFVLRLPPlygIRAEDLAKALIDGGFHAptmyLPVDGTLMIEPTETETKEELDALLEAL 398
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02414 |
PLN02414 |
glycine dehydrogenase (decarboxylating) |
51-1009 |
0e+00 |
|
glycine dehydrogenase (decarboxylating)
Pssm-ID: 178035 [Multi-domain] Cd Length: 993 Bit Score: 1488.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 51 RLLERLLPRH------------DDFARRHIGPGDKDQKEMLQALGLASVDELIEKTIPASIRlKRPLKM---DDPVCENE 115
Cdd:PLN02414 11 GLLRRLVNEQtrsisvealkpsDTFPRRHNSATPEEQKAMAEYCGFDSLDALIDATVPKSIR-LDSMKLskyDEGLTESQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 116 ILATLHAISNKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANAS 195
Cdd:PLN02414 90 MLEHMKSLASKNKVFKSYIGMGYYNTHVPPVILRNILENPGWYTQYTPYQAEIAQGRLESLLNYQTMITDLTGLPMSNAS 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 196 LLDEATAAAEAMQLCHRQNKRRK--FFVDPRCHPQTIAVVQTRAKYSGVLIELKLPHEMDFSSKDVSGVLFQYPDTEGKV 273
Cdd:PLN02414 170 LLDEGTAAAEAMAMCNNILKGKKkkFLIASNCHPQTIDVCQTRADGLGLEVVVADEKDFDYSSGDVCGVLVQYPATDGEV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 274 EDFTELVERAHEAGSLACCATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRENLVRMMPGRMVGVTR 353
Cdd:PLN02414 250 LDYAEFVKNAHANGVKVVMATDLLALTMLKPPGEWGADIVVGSAQRFGVPMGYGGPHAAFLATSQEYKRLMPGRIIGVSV 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 354 DVSGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAVMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQHDL 433
Cdd:PLN02414 330 DSSGKPALRMAMQTREQHIRRDKATSNICTAQALLANMAAMYAVYHGPEGLKTIAQRVHGLAGVFAAGLKKLGFQVQSLP 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 434 FFDTLKIQCGcSVKEVLGRAAQRQINIRLFEDGTLGISLDETVNEKDLDDLLWIFGCESSAELVAESMGEERRGILGTAF 513
Cdd:PLN02414 410 FFDTVKVKCS-DADAIADAAAKVGINLRVVDANTVTVSFDETTTLEDVDKLFKVFAGGKPVPFTAESLAPEVDSSIPSSL 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 514 KRTSPFLTHQVFNSYHSETNIVRYMKRLENKDISLVHSMIPLGSCTMKLNSSSELTPITWKEFANIHPFVPLDQAQGYQQ 593
Cdd:PLN02414 489 ARESPYLTHPIFNQYHSEHELLRYLHRLQNKDLSLVHSMIPLGSCTMKLNATTEMMPVTWPEFANIHPFAPVDQAQGYQE 568
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 594 LFRELEKDLCELTGYDRISFQPNSGAQGEYAGLASIRAYLDAKGETHRTVCLIPKSAHGTNPASAHMAGMRIQPVEVDKY 673
Cdd:PLN02414 569 MFEDLGDLLCEITGFDSFSLQPNAGAAGEYAGLMVIRAYHLSRGDHHRNVCIIPVSAHGTNPASAAMCGMKIVVVGTDAK 648
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 674 GNIDAAHLKAMVDKHKENLAAIMITYPSTNGVFEENIGDVCDLIHLHGGQVYLDGANMNAQVGLCRPGDFGSDVSHLNLH 753
Cdd:PLN02414 649 GNINIEELRKAAEAHKDNLAALMVTYPSTHGVYEEGIDEICDIIHDNGGQVYMDGANMNAQVGLTSPGFIGADVCHLNLH 728
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 754 KTFCIPHGGGGPGMGPIGVKKHLVPFLPNHPII---SLKPSEDAQALGTVSAAPWGSSCILPISWAYIKMMGGKGLKQAT 830
Cdd:PLN02414 729 KTFCIPHGGGGPGMGPIGVKKHLAPFLPSHPVVptgGIPRPEKTQPLGTISAAPWGSALILPISYTYIAMMGSEGLTDAS 808
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 831 EIAILNANYMAKRLEKHYRVLFRGARGYVAHEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWPVAGTLMIEPTES 910
Cdd:PLN02414 809 KIAILNANYMAKRLEGHYPVLFRGKNGTCAHEFIIDLRPFKNTAGIEPEDVAKRLMDYGFHAPTMSWPVPGTLMIEPTES 888
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 911 EDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSHWDRPYSREVAAFPLPFVKpENKFWPTISRID 990
Cdd:PLN02414 889 ESKAELDRFCDALISIREEIADIENGKADRENNVLKGAPHPPSLLMADKWDKPYSREYAAFPAPWVR-ASKFWPTTGRVD 967
|
970
....*....|....*....
gi 300794105 991 DIYGDQHLVCTCPPMDVYE 1009
Cdd:PLN02414 968 NVYGDRNLVCTLPSAAEEE 986
|
|
| gcvP |
TIGR00461 |
glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in ... |
66-1002 |
0e+00 |
|
glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in bacterial, mammalian and plant sources. The enzyme catalyzes the reaction: GLYCINE + LIPOYLPROTEIN = S-AMINOMETHYL-DIHYDROLIPOYLPROTEIN + CO2. It is part of the glycine decarboxylase multienzyme complex (GDC) consisting of four proteins P, H, L and T. Active site in E.coli is located as the (K) residues at position 713 of the SEED alignment. [Energy metabolism, Amino acids and amines]
Pssm-ID: 273089 [Multi-domain] Cd Length: 939 Bit Score: 1304.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 66 RHIGPGDKDQKEMLQALGLASVDELIEKTIPASIRLKRPLKMDDPVCENEILATLHAISNKNQIWRSYIGMGYYNCSVPQ 145
Cdd:TIGR00461 1 RHLGPGETEQRQMLQTLGFDTLNALIDQAVPPAIRFPRPLQLPAPQSEYGALAQLKSIASKNQVFRSYIGMGYYDTILPP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 146 TILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANASLLDEATAAAEAMQLCHR--QNKRRKFFVDP 223
Cdd:TIGR00461 81 VIQRNILENPGWYTAYTPYQPEISQGRLEALLNFQTVVMDLTGLEIANASLLDEGTAAAEAMALSYGvsKSKANAFFVAQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 224 RCHPQTIAVVQTRAKYSGVLIELKLPHEMDFSSkDVSGVLFQYPDTEGKVEDFTELVERAHEAGSLACCATDLLALCILR 303
Cdd:TIGR00461 161 DCHPQTIEVIKTRANPFGIEVIVGDHHTFSFST-DVFGALLQYPATDGAIYDYRSLIDKLHSHKALVSVAADPMALTLLT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 304 PPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRENLVRMMPGRMVGVTRDVSGKEVYRLALQTREQHIRRDKATSNICT 383
Cdd:TIGR00461 240 PPGELGADIVVGSTQRFGVPMGYGGPHAAFFATKDEYQRKMPGRIVGVSKDAHGNTALRLALQTREQHIRRDKATSNICT 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 384 AQALLANMAVMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQHDLFFDTLKIQCG-CSVKEVLGRAAQRQINIRL 462
Cdd:TIGR00461 320 AQVLLANMASMYGVYHGPTGLKNIALRIHQLTVILAIGLKRLNYSLNNDYFFDTLRVGVGeQSAPAILKAAEGRGINLRP 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 463 FEDGTLGISLDETVNEKDLDDLLWIFGCESSAELVAESMGEERRGILGTAFKRTSPFLTHQVFNSYHSETNIVRYMKRLE 542
Cdd:TIGR00461 400 LVPGEVGISLDETTTVQDVLDLWQVFAGKDNLPFTPEELWSDVKTSFPADLTRQDEILQDAVFNQYHSETEMLRYLHQLE 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 543 NKDISLVHSMIPLGSCTMKLNSSSELTPITWKEFANIHPFVPLDQAQGYQQLFRELEKDLCELTGYDRISFQPNSGAQGE 622
Cdd:TIGR00461 480 SKDLALNTSMIPLGSCTMKLNATAEMMPITWPEFGKIHPFAPAGQTEGYQILIAQLEAWLGEITGFDAISLQPNSGAQGE 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 623 YAGLASIRAYLDAKGETHRTVCLIPKSAHGTNPASAHMAGMRIQPVEVDKYGNIDAAHLKAMVDKHKENLAAIMITYPST 702
Cdd:TIGR00461 560 YAGLQVIRQYHESRGEEHRNICLIPESAHGTNPASAVMAGMQVVPVKCDGEGNIDLEDLTSKAEQYGDRLAALMVTYPST 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 703 NGVFEENIGDVCDLIHLHGGQVYLDGANMNAQVGLCRPGDFGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLVPFLPN 782
Cdd:TIGR00461 640 HGVFEATIGTICDIVHRFGGQVYLDGANMNAQVGLTSPGDFGADVCHLNLHKTFCIPHGGGGPGMGPIGVKSHLQPFLPR 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 783 HPIISLKPSE-DAQALGTVSAAPWGSSCILPISWAYIKMMGGKGLKQATEIAILNANYMAKRLEKHYRVLFRGARGYVAH 861
Cdd:TIGR00461 720 HSLNSTAELQgEDQSIGMVSAAPYGSASILPISWMYIAMMGPEGLTKASEVAILNANYMAKRLEDYYPILFRGNNELVAH 799
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 862 EFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWPVAGTLMIEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDPR 941
Cdd:TIGR00461 800 ECILDLRPLKKQAGIEVEDVAKRLMDYGFHAPTVSFPVLGTLMVEPTESESLGELDRFCDAMIAIYQEIQAITAGEIDPA 879
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 300794105 942 VNPLKMSPHSLTCVTSSHWDRPYSREVAAFPLPFVKpENKFWPTISRIDDIYGDQHLVCTC 1002
Cdd:TIGR00461 880 DNPLKNAPHTAQSLICGEWNHPYSREEAAYPAPWTK-QFKFWPTVGRLDDTYGDRNLVCSC 939
|
|
| GDC-P |
pfam02347 |
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ... |
65-488 |
0e+00 |
|
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
Pssm-ID: 396772 [Multi-domain] Cd Length: 428 Bit Score: 764.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 65 RRHIGPGDKDQKEMLQALGLASVDELIEKTIPASIRLKRPLKMDDPVCENEILATLHAISNKNQIWRSYIGMGYYNCSVP 144
Cdd:pfam02347 1 DRHIGPSEKDQQEMLATLGYSSLDDLIGKAVPKNIRFAKPLQLPAPKSEYEALAELEAIASKNTVYRSFIGMGYYDTILP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 145 QTILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANASLLDEATAAAEAMQLCHRQNKRR--KFFVD 222
Cdd:pfam02347 81 PVILRNILENPEWYTAYTPYQPEISQGRLEALLNFQTMICDLTGLDIANASLLDEGTAAAEAMALAARASKKKgkKFVVD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 223 PRCHPQTIAVVQTRAKYSGVLIELKLPHEMDFS-SKDVSGVLFQYPDTEGKVEDFTELVERAHEAGSLACCATDLLALCI 301
Cdd:pfam02347 161 KDVHPQTLEVLKTRAKPFGIEIVEVDYTEEGVTdLKDVFGVLVQYPNTDGRIEDYKELIELAHQRKSLVVVAADLLALTL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 302 LRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRENLVRMMPGRMVGVTRDVSGKEVYRLALQTREQHIRRDKATSNI 381
Cdd:pfam02347 241 LKPPGEFGADIAVGSAQRFGVPLGYGGPHAGFFAVKKELVRKMPGRLVGVSKDANGKRALRLALQTREQHIRRDKATSNI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 382 CTAQALLANMAVMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQHDLFFDTLKIQCG-CSVKEVLGRAAQRQINI 460
Cdd:pfam02347 321 CTAQALLANMASMYAVYHGPNGLKEIARRIHSLTLYLAKALKKLGHELVHKHFFDTLLIEVEdKAVEEVLARAEARGINL 400
|
410 420
....*....|....*....|....*...
gi 300794105 461 RLFEDGTLGISLDETVNEKDLDDLLWIF 488
Cdd:pfam02347 401 RYVDLGHVGIALDETVTKEDIDDLLQVF 428
|
|
| GcvP2 |
COG1003 |
Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport ... |
509-1001 |
0e+00 |
|
Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440627 Cd Length: 468 Bit Score: 734.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 509 LGTAFKRTSPflthqVFNSYHSETNIVRYMKRLENKDISLVHSMIPLGSCTMKLNSSSELTPITWKEFANIHPFVPLDQA 588
Cdd:COG1003 14 LPEALLRKSP-----VFLPEVSETEVLRHYTRLSQKNLGLDTGMIPLGSCTMKYNPKINEEPATLPGFANLHPFQPEETV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 589 QGYQQLFRELEKDLCELTGYDRISFQPNSGAQGEYAGLASIRAYLDAKGETHRTVCLIPKSAHGTNPASAHMAGMRIQPV 668
Cdd:COG1003 89 QGYLELMYELEEWLAEITGMDAVSLQPNAGAQGEYAGLLAIRAYHESRGEGHRNEILIPDSAHGTNPASAAMAGFKVVVV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 669 EVDKYGNIDAAHLKAMVDkhkENLAAIMITYPSTNGVFEENIGDVCDLIHLHGGQVYLDGANMNAQVGLCRPGDFGSDVS 748
Cdd:COG1003 169 KSDEDGNVDLEDLKAKVG---DRTAALMLTNPSTHGVFEEDIKEICDIVHEAGGLVYYDGANLNAIVGLARPGDMGFDVC 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 749 HLNLHKTFCIphggggpgmgpigVKKHLVPFLPNHPII----SLKPSEDAQALGTVSAAPWGSSCILPISWAYIKMMGGK 824
Cdd:COG1003 246 HLNLHKTFSTphggggpgsgpvgVKEHLAPFLPGPPVVkdgdKYRLDYDRPKSIGRSAAFYGNAGVLVRAYAYIRMMGAE 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 825 GLKQATEIAILNANYMAKRLEKHYRVLFRGaRGYVAHEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWP--VAGT 902
Cdd:COG1003 326 GLREATEVAVLNANYLAARLKDHYPVLYTG-NGRCAHEFILDLRPLKKETGVTTLDIAKRLLDYGFHAPTMYFPliVPET 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 903 LMIEPTESEDKAELDRFCDAMISIRQEIADieegriDPrvNPLKMSPHSLtcvtsshwdrpysrevaafplpfvkpenkf 982
Cdd:COG1003 405 LMIEPTESESKEELDRFIDAMIAIREEARE------DP--EPLKNAPHTT------------------------------ 446
|
490
....*....|....*....
gi 300794105 983 wpTISRIDDIYGDQHLVCT 1001
Cdd:COG1003 447 --PVRRLDEVYADRNLVLT 463
|
|
| GcvP1 |
COG0403 |
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ... |
61-489 |
0e+00 |
|
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440172 [Multi-domain] Cd Length: 442 Bit Score: 651.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 61 DDFARRHIGPGDKDQKEMLQALGLASVDELIEKtIPASIRLKRPLKMDDPVCENEILATLHAISNKNQIWRSYIGMGYYN 140
Cdd:COG0403 1 DEFAMRYIPPTEEDRAEMLAAIGVDSLDELFDD-IPAEIRLKRPLDLPEALSEAELLRHLRALAAKNKVLTSFIGAGYYD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 141 CSVPQTIlRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANASLLDEATAAAEAMQLCHRQNKR-RKF 219
Cdd:COG0403 80 HYVPAVV-RNILERPEFYTAYTPYQPEISQGRLQALFEFQTMVAELTGMDVANASLYDGATAAAEAMLMARRVTKRsNKV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 220 FVDPRCHPQTIAVVQTRAKYSGV-LIELKLPH-EMDFS------SKDVSGVLFQYPDTEGKVEDFTELVERAHEAGSLAC 291
Cdd:COG0403 159 LVSEDVHPQTRAVLKTYAEPLGIeVVEVPDEDgVTDLEalkallDDDVAGVLVQYPNFFGVIEDLRAIAEAAHAAGALVI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 292 CATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRENLVRMMPGRMVGVTRDVSGKEVYRLALQTREQH 371
Cdd:COG0403 239 VAADPLSLGLLKPPGELGADIVVGEGQRLGVPLGFGGPHAGFFATREKLVRQMPGRLVGVTVDADGKRAFRLTLQTREQH 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 372 IRRDKATSNICTAQALLANMAVMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQ-HDLFFDTLKIQCGCSVKEVL 450
Cdd:COG0403 319 IRREKATSNICTNQALLALAASMYAVYHGPEGLKEIAERIHQKAHYLAERLAALGVEVPfNGPFFDEFVVRLPKPAAEIN 398
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 300794105 451 GRAAQRQI----NIRLFEDGTLGISLDETVNEKDLDDLLWIFG 489
Cdd:COG0403 399 AALLEKGIlgglNLRRVDDDTLLVAVTETTTKEDIDALVEALA 441
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
113-488 |
7.24e-175 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 515.63 E-value: 7.24e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 113 ENEILATLHAISNKNQIWR---SYIGMGYYNCSVPQTILRNLLENsGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGL 189
Cdd:cd00613 1 ETEVLRHLKRLASKNKALDqsmSFLGSGTYKHNPPAVIKRNILEN-EFYTAYTPYQPEISQGRLQALFELQTMLCELTGM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 190 DMANASLLDEATAAAEAMQLCHRQNK--RRKFFVDPRCHPQTIAVVQTRAKYSGVLIELKLPHEM---------DFSSKD 258
Cdd:cd00613 80 DVANASLQDEATAAAEAAGLAAIRAYhkRNKVLVPDSAHPTNPAVARTRGEPLGIEVVEVPSDEGgtvdlealkEEVSEE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 259 VSGVLFQYPDTEGKVEDF-TELVERAHEAGSLACCATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVR 337
Cdd:cd00613 160 VAALMVQYPNTLGVFEDLiKEIADIAHSAGALVYVDGDNLNLTGLKPPGEYGADIVVGNLQKTGVPHGGGGPGAGFFAVK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 338 ENLVRMMPGRMVGVTRDVSGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAVMFAIYHGSHGLEHIARRVHNATLI 417
Cdd:cd00613 240 KELVRFLPGRLVGVTKDAEGNRAFRLALQTREQHIRREKATSNICTGQALLALMAAMYIVYLGPEGLKEIAERAHLNANY 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300794105 418 LSEGLKRAGHQLQ-HDLFFDTLKIQCGC---SVKEVLGRAAQRQINIR----LFEDGTLGISLDETVNEKDLDDLLWIF 488
Cdd:cd00613 320 LAKRLKEVGGVLPfNGPFFHEFVLRLPPlygIRAEDLAKALIDGGFHAptmyLPVDGTLMIEPTETETKEELDALLEAL 398
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
531-923 |
2.60e-159 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 475.57 E-value: 2.60e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 531 ETNIVRYMKRLENKDISLVHSMIPLGSCTMKLNSSSELTPITWK-EFANIHPFVPLDQAQGYQQLFRELEKDLCELTGYD 609
Cdd:cd00613 1 ETEVLRHLKRLASKNKALDQSMSFLGSGTYKHNPPAVIKRNILEnEFYTAYTPYQPEISQGRLQALFELQTMLCELTGMD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 610 --RISFQPNSGAQGEYAGLASIRAYLdakgetHRTVCLIPKSAHGTNPASAHMA----GMRIQPVEVDKYGNIDaahLKA 683
Cdd:cd00613 81 vaNASLQDEATAAAEAAGLAAIRAYH------KRNKVLVPDSAHPTNPAVARTRgeplGIEVVEVPSDEGGTVD---LEA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 684 MVDKHKENLAAIMITYPSTNGVFEENIGDVCDLIHLHGGQVYLDGANMNAQvGLCRPGDFGSDVSHLNLHKTF------- 756
Cdd:cd00613 152 LKEEVSEEVAALMVQYPNTLGVFEDLIKEIADIAHSAGALVYVDGDNLNLT-GLKPPGEYGADIVVGNLQKTGvphgggg 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 757 ------CiphggggpgmgpigVKKHLVPFLPNHPIIslkPSEDAQ-------ALGT----------VSAAPWGSSCILPI 813
Cdd:cd00613 231 pgagffA--------------VKKELVRFLPGRLVG---VTKDAEgnrafrlALQTreqhirrekaTSNICTGQALLALM 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 814 SWAYIKMMGGKGLKQATEIAILNANYMAKRLEKHYRVLfrGARGYVAHEFILDTRPFkksANIEAVDVAKRLQDYGFHAP 893
Cdd:cd00613 294 AAMYIVYLGPEGLKEIAERAHLNANYLAKRLKEVGGVL--PFNGPFFHEFVLRLPPL---YGIRAEDLAKALIDGGFHAP 368
|
410 420 430
....*....|....*....|....*....|
gi 300794105 894 TMSWPVAGTLMIEPTESEDKAELDRFCDAM 923
Cdd:cd00613 369 TMYLPVDGTLMIEPTETETKEELDALLEAL 398
|
|
| PRK04366 |
PRK04366 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPB; |
530-953 |
1.84e-141 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPB;
Pssm-ID: 235292 Cd Length: 481 Bit Score: 432.23 E-value: 1.84e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 530 SETNIVRYMKRLENKDISLVHSMIPLGSCTMKLNssseltP-ITWK-----EFANIHPFVPLDQAQGYQQLFRELEKDLC 603
Cdd:PRK04366 50 SELEVVRHYTRLSQKNYGVDTGFYPLGSCTMKYN------PkINEKvarlpGFAELHPLQPEETVQGALELMYELQEWLK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 604 ELTGYDRISFQPNSGAQGEYAGLASIRAYLDAKGETHRTVCLIPKSAHGTNPASAHMAGMRIQPVEVDKYGNIDAAHLKA 683
Cdd:PRK04366 124 EITGMDAVTLQPAAGAHGELTGLLMIRAYHEARGDTKRTEVIVPDSAHGTNPASAAMAGFKVVEIPSNEDGLVDLEALKA 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 684 MVDkhkENLAAIMITYPSTNGVFEENIGDVCDLIHLHGGQVYLDGANMNAQVGLCRPGDFGSDVSHLNLHKTFCIPHGGG 763
Cdd:PRK04366 204 AVG---EDTAALMLTNPNTLGLFERNILEIAEIVHEAGGLLYYDGANLNAILGKARPGDMGFDVVHLNLHKTFSTPHGGG 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 764 GPGMGPIGVKKHLVPFLPnHPIISLKPS------EDAQALGTVSAApWGSSCILPISWAYIKMMGGKGLKQATEIAILNA 837
Cdd:PRK04366 281 GPGSGPVGVKEELAPFLP-VPVVEKDGDryrldyDRPKSIGRVRAF-YGNFGVLVRAYAYIRSLGAEGLREVSEDAVLNA 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 838 NYMAKRLEKHYRVLFRGARgyvAHEFILDTRPFKKSaNIEAVDVAKRLQDYGFHAPTMSWP--VAGTLMIEPTESEDKAE 915
Cdd:PRK04366 359 NYLKARLKDIYDLPYDRPC---MHEFVLSGKKLKET-GVRTLDIAKRLLDYGFHPPTIYFPliVPEALMIEPTETESKET 434
|
410 420 430
....*....|....*....|....*....|....*...
gi 300794105 916 LDRFCDAMISIRqeiadiEEGRIDPRVnpLKMSPHSLT 953
Cdd:PRK04366 435 LDAFIAAMKQIA------EEAKENPEL--VKEAPHNTP 464
|
|
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
72-458 |
4.80e-122 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 380.25 E-value: 4.80e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 72 DKDQKEMLQALGLASVDELIEKtIPASIRLKRPLKMDDPVCENEILATLHAISNKNQIWR---SYIGMGYYNCSVPqTIL 148
Cdd:PRK00451 9 EEDIREMLDAIGVKSIDELFAD-IPEELRLKRPLDLPPGLSEMELLRHLRELAAKNKTAEeypSFLGAGAYDHYIP-AVV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 149 RNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANASLLDEATAAAEAMQLCHRQNKRRKFFVDPRCHPQ 228
Cdd:PRK00451 87 DHIISRSEFYTAYTPYQPEISQGTLQAIFEYQTMICELTGMDVANASMYDGATALAEAALMAVRITKRKKVLVSGAVHPE 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 229 TIAVVQTRAKYSGV-LIELKLPHEM-------DFSSKDVSGVLFQYPDTEGKVEDFTELVERAHEAGSLACCATDLLALC 300
Cdd:PRK00451 167 YREVLKTYLKGQGIeVVEVPYEDGVtdlealeAAVDDDTAAVVVQYPNFFGVIEDLEEIAEIAHAGGALFIVGVDPVSLG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 301 ILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRENLVRMMPGRMVGVTRDVSGKEVYRLALQTREQHIRRDKATSN 380
Cdd:PRK00451 247 LLKPPGEYGADIVVGEGQPLGIPLSFGGPYLGFFATRKKLVRQMPGRLVGETVDADGKRGFVLTLQAREQHIRREKATSN 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 381 ICTAQALlanMAVMFAIY---HGSHGLEHIARRVHNATLILSEGLKRAGHQLQHDL-FFDTLKIQCGCSVKEVLGRAAQR 456
Cdd:PRK00451 327 ICTNQAL---NALAAAIYmslLGPEGLRELAEQNHQKAHYLAERLAEIGGVELFDGpFFNEFVVRLPKPAEEVNEALLEK 403
|
..
gi 300794105 457 QI 458
Cdd:PRK00451 404 GI 405
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
597-757 |
3.35e-11 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 62.79 E-value: 3.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 597 ELEKDLCELT--GYDRISFQPnSGAQGEYAGLASIRayldakgETHRTVcLIPKSAHGTNPAS-AHMAGMRIQPVEVDKY 673
Cdd:cd01494 4 ELEEKLARLLqpGNDKAVFVP-SGTGANEAALLALL-------GPGDEV-IVDANGHGSRYWVaAELAGAKPVPVPVDDA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 674 GNiDAAHLKAMVD-KHKENLAAIMITYPSTNGVFEENIGDVCDLIHLHGGQVYLDGANMNAQVG--LCRPGDFGSDVSHL 750
Cdd:cd01494 75 GY-GGLDVAILEElKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGASPapGVLIPEGGADVVTF 153
|
....*..
gi 300794105 751 NLHKTFC 757
Cdd:cd01494 154 SLHKNLG 160
|
|
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
588-923 |
9.09e-06 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 49.37 E-value: 9.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 588 AQG-YQQLFrELEKDLCELTG--------YDrisfqpnsGAQGeyagLASirAYLDAKGETHRTVCLIPKSAHgtnPAS- 657
Cdd:PRK00451 107 SQGtLQAIF-EYQTMICELTGmdvanasmYD--------GATA----LAE--AALMAVRITKRKKVLVSGAVH---PEYr 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 658 ------AHMAGMRIQPVEVDKyGNIDAAHLKAMVDkhkENLAAIMITYPSTNGVFEEnIGDVCDLIHLHGGQVYLdGANM 731
Cdd:PRK00451 169 evlktyLKGQGIEVVEVPYED-GVTDLEALEAAVD---DDTAAVVVQYPNFFGVIED-LEEIAEIAHAGGALFIV-GVDP 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 732 NAQVGLCRPGDFGSDV---------SHLN-------LhktFCiphggggpgmgpigVKKHLVPFLPNHpIISLKPSED-- 793
Cdd:PRK00451 243 VSLGLLKPPGEYGADIvvgegqplgIPLSfggpylgF---FA--------------TRKKLVRQMPGR-LVGETVDADgk 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 794 -------------------------AQALGTVSAApwgsscilpiswAYIKMMGGKGLKQATEIAILNANYMAKRLEKH- 847
Cdd:PRK00451 305 rgfvltlqareqhirrekatsnictNQALNALAAA------------IYMSLLGPEGLRELAEQNHQKAHYLAERLAEIg 372
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 848 YRVLFRGARGyvaHEFILDTrpfkksaNIEAVDVAKRLQDYGFHA--------PTMswpvAGTLMIEPTESEDKAELDRF 919
Cdd:PRK00451 373 GVELFDGPFF---NEFVVRL-------PKPAEEVNEALLEKGILGgydlgryyPEL----GNHLLVCVTEKRTKEDIDAL 438
|
....
gi 300794105 920 CDAM 923
Cdd:PRK00451 439 VAAL 442
|
|
| GcvP1 |
COG0403 |
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ... |
658-923 |
9.51e-05 |
|
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440172 [Multi-domain] Cd Length: 442 Bit Score: 46.18 E-value: 9.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 658 AHMAGMRIqpVEV-DKYGNIDAAHLKAMVDkhkENLAAIMITYPSTNGVFEEnIGDVCDLIHLHGGQVYLdGANMNAQVG 736
Cdd:COG0403 176 AEPLGIEV--VEVpDEDGVTDLEALKALLD---DDVAGVLVQYPNFFGVIED-LRAIAEAAHAAGALVIV-AADPLSLGL 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 737 LCRPGDFGSDVS----------------HLNLhktFCiphggggpgmgpigVKKHLVPFLPNHpIISLkpSED------- 793
Cdd:COG0403 249 LKPPGELGADIVvgegqrlgvplgfggpHAGF---FA--------------TREKLVRQMPGR-LVGV--TVDadgkraf 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 794 ----------------------AQALGTVSAApwgsscilpiswAYIKMMGGKGLKQATEIAILNANYMAKRLEK-HYRV 850
Cdd:COG0403 309 rltlqtreqhirrekatsnictNQALLALAAS------------MYAVYHGPEGLKEIAERIHQKAHYLAERLAAlGVEV 376
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 300794105 851 LFRGArgyVAHEFILDTrpfkksaNIEAVDVAKRLQDYGFHAPT-MSWPVAGTLMIEPTESEDKAELDRFCDAM 923
Cdd:COG0403 377 PFNGP---FFDEFVVRL-------PKPAAEINAALLEKGILGGLnLRRVDDDTLLVAVTETTTKEDIDALVEAL 440
|
|
| Beta_elim_lyase |
pfam01212 |
Beta-eliminating lyase; |
586-729 |
1.88e-04 |
|
Beta-eliminating lyase;
Pssm-ID: 426128 [Multi-domain] Cd Length: 288 Bit Score: 44.51 E-value: 1.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 586 DQAQGYQQLFRELEKDLCELTGYDRISFQPnSGAQGEyagLASIRAYLDAKGEThrtVCLIPksAHG---TNPASAHMAG 662
Cdd:pfam01212 25 DEVYGGDPTVNRLEDRVAELFGKEAALFVP-SGTAAN---QLALMAHCQRGDEV---ICGEP--AHIhfdETGGHAELGG 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300794105 663 MRIQPVEVDKYGNIDAAHLKAMVDKHK----ENLAAIMITypSTNG------VFEENIGDVCDLIHLHGGQVYLDGA 729
Cdd:pfam01212 96 VQPRPLDGDEAGNMDLEDLEAAIREVGadifPPTGLISLE--NTHNsaggqvVSLENLREIAALAREHGIPVHLDGA 170
|
|
| DOPA_deC_like |
cd06450 |
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
623-715 |
9.38e-04 |
|
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Pssm-ID: 99743 [Multi-domain] Cd Length: 345 Bit Score: 42.58 E-value: 9.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794105 623 YAGLA---SIRAYLDAKG--ETHRTVCLIPKSAHGTNPASAHMAGMRIQPVEVDKYGNIDAAHLKAMVDKHK-ENLAAIM 696
Cdd:cd06450 72 LALLAardRARKRLKAGGgrGIDKLVIVCSDQAHVSVEKAAAYLDVKVRLVPVDEDGRMDPEALEAAIDEDKaEGLNPIM 151
|
90 100
....*....|....*....|....
gi 300794105 697 I--TYPSTN-GVFE--ENIGDVCD 715
Cdd:cd06450 152 VvaTAGTTDtGAIDplEEIADLAE 175
|
|
| |
