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Conserved domains on  [gi|300795532|ref|NP_001178928|]
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phospholipid scramblase family member 5 [Rattus norvegicus]

Protein Classification

phospholipid scramblase family protein( domain architecture ID 10510595)

phospholipid scramblase family protein similar to mammalian phospholipid scramblase and Saccharomyces cerevisiae altered inheritance rate of mitochondria protein 25

Gene Ontology:  GO:0017128
PubMed:  11487015|19010806

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Scramblase pfam03803
Scramblase; Scramblase is palmitoylated and contains a potential protein kinase C ...
48-268 6.12e-98

Scramblase; Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site. Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury.


:

Pssm-ID: 252175  Cd Length: 221  Bit Score: 286.17  E-value: 6.12e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795532   48 PSSFLPTAILPPGLEYLSQLDLIIIHQQVELLGMILGTETSNKYEIKNSSGQRIYFAVEESICFNRNVCSTLRACTLRIT 127
Cdd:pfam03803   2 SGPGQPPANCPAGLEYLLQLDQILVHQQIEPLEVFTGFETANRYVVKNVNGQPLYYAMERSNCCARQCCGTHRPFVMRIT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795532  128 DNSGREVITVNRPLRCNSCwCPCYLQELEIQAPPGTIVGFVAQKWDPFQPKFTIQNANKEDILKIVGPCTTCGCFGDVDF 207
Cdd:pfam03803  82 DNFGNEVMTLKRPFSCISC-CPSCLQEQEIQAPPGTTIGEVLQTWHLWRPNYELQNADGNQVLSIFGPCFKCDCGGDWEF 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 300795532  208 EVKTVDEKVtIGKISKYWSGFVNDVFTNADNFGIHVPEDLDVTLKAAMIGACFLFDFMFFE 268
Cdd:pfam03803 161 PVKTADGEV-VGSISRNWPGLGREAFTDADTYVVRFPLDLDVKLKAVLLGAAFLIDFMYFE 220
 
Name Accession Description Interval E-value
Scramblase pfam03803
Scramblase; Scramblase is palmitoylated and contains a potential protein kinase C ...
48-268 6.12e-98

Scramblase; Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site. Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury.


Pssm-ID: 252175  Cd Length: 221  Bit Score: 286.17  E-value: 6.12e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795532   48 PSSFLPTAILPPGLEYLSQLDLIIIHQQVELLGMILGTETSNKYEIKNSSGQRIYFAVEESICFNRNVCSTLRACTLRIT 127
Cdd:pfam03803   2 SGPGQPPANCPAGLEYLLQLDQILVHQQIEPLEVFTGFETANRYVVKNVNGQPLYYAMERSNCCARQCCGTHRPFVMRIT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795532  128 DNSGREVITVNRPLRCNSCwCPCYLQELEIQAPPGTIVGFVAQKWDPFQPKFTIQNANKEDILKIVGPCTTCGCFGDVDF 207
Cdd:pfam03803  82 DNFGNEVMTLKRPFSCISC-CPSCLQEQEIQAPPGTTIGEVLQTWHLWRPNYELQNADGNQVLSIFGPCFKCDCGGDWEF 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 300795532  208 EVKTVDEKVtIGKISKYWSGFVNDVFTNADNFGIHVPEDLDVTLKAAMIGACFLFDFMFFE 268
Cdd:pfam03803 161 PVKTADGEV-VGSISRNWPGLGREAFTDADTYVVRFPLDLDVKLKAVLLGAAFLIDFMYFE 220
YxjI COG4894
Putative phospholipid scramblase YxjI, Tubby2 superfamily [Lipid transport and metabolism];
88-265 1.62e-11

Putative phospholipid scramblase YxjI, Tubby2 superfamily [Lipid transport and metabolism];


Pssm-ID: 443922  Cd Length: 163  Bit Score: 61.01  E-value: 1.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795532  88 SNKYEIKNSSGQRIYFAVEESICFNRnvcstlracTLRITDNSGREVITVNRPLrcnSCWCPCYlqELEIQappGTIVGF 167
Cdd:COG4894   14 GDDFTIYDENGQPVYLVKGKFFSLGD---------TLSIYDADGNELATIKQKL---FSLLPTF--EIYDD---GEPVAT 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795532 168 VAQKWDPFQPKFTIqNANKEDiLKIVGPcttcgcFGDVDFEVkTVDEKVtIGKISKYWsgfvndvFTNADNFGIHVPEDL 247
Cdd:COG4894   77 IKKKFTFFKDRFTI-EADGLD-LEIEGD------FWDHDFEI-TRGGKV-VASVSKKW-------FSWRDTYELDIDDEE 139
                        170
                 ....*....|....*...
gi 300795532 248 DvtlKAAMIGACFLFDFM 265
Cdd:COG4894  140 D---RPLVIALAIAIDAV 154
 
Name Accession Description Interval E-value
Scramblase pfam03803
Scramblase; Scramblase is palmitoylated and contains a potential protein kinase C ...
48-268 6.12e-98

Scramblase; Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site. Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury.


Pssm-ID: 252175  Cd Length: 221  Bit Score: 286.17  E-value: 6.12e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795532   48 PSSFLPTAILPPGLEYLSQLDLIIIHQQVELLGMILGTETSNKYEIKNSSGQRIYFAVEESICFNRNVCSTLRACTLRIT 127
Cdd:pfam03803   2 SGPGQPPANCPAGLEYLLQLDQILVHQQIEPLEVFTGFETANRYVVKNVNGQPLYYAMERSNCCARQCCGTHRPFVMRIT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795532  128 DNSGREVITVNRPLRCNSCwCPCYLQELEIQAPPGTIVGFVAQKWDPFQPKFTIQNANKEDILKIVGPCTTCGCFGDVDF 207
Cdd:pfam03803  82 DNFGNEVMTLKRPFSCISC-CPSCLQEQEIQAPPGTTIGEVLQTWHLWRPNYELQNADGNQVLSIFGPCFKCDCGGDWEF 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 300795532  208 EVKTVDEKVtIGKISKYWSGFVNDVFTNADNFGIHVPEDLDVTLKAAMIGACFLFDFMFFE 268
Cdd:pfam03803 161 PVKTADGEV-VGSISRNWPGLGREAFTDADTYVVRFPLDLDVKLKAVLLGAAFLIDFMYFE 220
YxjI COG4894
Putative phospholipid scramblase YxjI, Tubby2 superfamily [Lipid transport and metabolism];
88-265 1.62e-11

Putative phospholipid scramblase YxjI, Tubby2 superfamily [Lipid transport and metabolism];


Pssm-ID: 443922  Cd Length: 163  Bit Score: 61.01  E-value: 1.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795532  88 SNKYEIKNSSGQRIYFAVEESICFNRnvcstlracTLRITDNSGREVITVNRPLrcnSCWCPCYlqELEIQappGTIVGF 167
Cdd:COG4894   14 GDDFTIYDENGQPVYLVKGKFFSLGD---------TLSIYDADGNELATIKQKL---FSLLPTF--EIYDD---GEPVAT 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795532 168 VAQKWDPFQPKFTIqNANKEDiLKIVGPcttcgcFGDVDFEVkTVDEKVtIGKISKYWsgfvndvFTNADNFGIHVPEDL 247
Cdd:COG4894   77 IKKKFTFFKDRFTI-EADGLD-LEIEGD------FWDHDFEI-TRGGKV-VASVSKKW-------FSWRDTYELDIDDEE 139
                        170
                 ....*....|....*...
gi 300795532 248 DvtlKAAMIGACFLFDFM 265
Cdd:COG4894  140 D---RPLVIALAIAIDAV 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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