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Conserved domains on  [gi|300795677|ref|NP_001178679|]
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interleukin-12 receptor subunit beta-2 precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 28-120 2.92e-16

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


:

Pssm-ID: 461878  Cd Length: 87  Bit Score: 74.59  E-value: 2.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677   28 CKLGTVTVqPAPVIPLGSTANISCSLNPKQgCSHYPSYNELILLKFVNdvlvEKLHGKKVHGHPSHSSIFQVTNLSLGMT 107
Cdd:pfam06328   1 EPCGHISP-SPPVVRLGSNVTASCILKENC-CSHLGVEAQIIVWKLGL----ELIPGSQYTVLNDTVSSVTLPNLNSTRA 74

                          90
                  ....*....|...
gi 300795677  108 LFVCKLNCSNSQK 120
Cdd:pfam06328  75 LLTCCLLWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 240-332 3.45e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.51  E-value: 3.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677 240 PLPPWDIRINflNASGSRCTLQWE----DEGQVVLNRLRYQPLNSTSWNMVNATNAKG-RYDLQDLRPFTEYEFQISSKl 314
Cdd:cd00063    1 PSPPTNLRVT--DVTSTSVTLSWTppedDGGPITGYVVEYREKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAV- 77

                         90
                 ....*....|....*...
gi 300795677 315 hlSQGSWSNWSESLRTRT 332
Cdd:cd00063   78 --NGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
438-526 4.91e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 51.26  E-value: 4.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677  438 APHQVSAKSGNMDNIMVTWQPPGKADSVIREYIVEWRALQQGSVmnltPHWLRIPPYNMSALISeKIKPYICYEIRVHAL 517
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEP----WNEITVPGTTTSVTLT-GLKPGTEYEVRVQAV 76


                  ....*....
gi 300795677  518 SEDQGGCSS 526
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 536-630 6.42e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 6.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677 536 PLSGPHITAITekKESLFISWThiPFLEQRGCILHYRIYWKERHSTaQPELCEIQyRHSQNSHPISSLQPKVTYVLWMTA 615
Cdd:cd00063    3 PPTNLRVTDVT--STSVTLSWT--PPEDDGGPITGYVVEYREKGSG-DWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRA 76

                         90
                 ....*....|....*
gi 300795677 616 VTAAGESPQGNEREF 630
Cdd:cd00063   77 VNGGGESPPSESVTV 91
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 28-120 2.92e-16

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 74.59  E-value: 2.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677   28 CKLGTVTVqPAPVIPLGSTANISCSLNPKQgCSHYPSYNELILLKFVNdvlvEKLHGKKVHGHPSHSSIFQVTNLSLGMT 107
Cdd:pfam06328   1 EPCGHISP-SPPVVRLGSNVTASCILKENC-CSHLGVEAQIIVWKLGL----ELIPGSQYTVLNDTVSSVTLPNLNSTRA 74

                          90
                  ....*....|...
gi 300795677  108 LFVCKLNCSNSQK 120
Cdd:pfam06328  75 LLTCCLLWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 240-332 3.45e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.51  E-value: 3.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677 240 PLPPWDIRINflNASGSRCTLQWE----DEGQVVLNRLRYQPLNSTSWNMVNATNAKG-RYDLQDLRPFTEYEFQISSKl 314
Cdd:cd00063    1 PSPPTNLRVT--DVTSTSVTLSWTppedDGGPITGYVVEYREKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAV- 77

                         90
                 ....*....|....*...
gi 300795677 315 hlSQGSWSNWSESLRTRT 332
Cdd:cd00063   78 --NGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
438-526 4.91e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 51.26  E-value: 4.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677  438 APHQVSAKSGNMDNIMVTWQPPGKADSVIREYIVEWRALQQGSVmnltPHWLRIPPYNMSALISeKIKPYICYEIRVHAL 517
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEP----WNEITVPGTTTSVTLT-GLKPGTEYEVRVQAV 76


                  ....*....
gi 300795677  518 SEDQGGCSS 526
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 438-526 5.18e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 5.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677 438 APHQVSAKSGNMDNIMVTWQPPGKADSVIREYIVEWRALQQGSVMNLTPHWLRIPPYNMSALisekiKPYICYEIRVHAL 517
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGL-----KPGTEYEFRVRAV 77


                 ....*....
gi 300795677 518 SEDQGGCSS 526
Cdd:cd00063   78 NGGGESPPS 86
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 536-630 6.42e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 6.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677 536 PLSGPHITAITekKESLFISWThiPFLEQRGCILHYRIYWKERHSTaQPELCEIQyRHSQNSHPISSLQPKVTYVLWMTA 615
Cdd:cd00063    3 PPTNLRVTDVT--STSVTLSWT--PPEDDGGPITGYVVEYREKGSG-DWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRA 76

                         90
                 ....*....|....*
gi 300795677 616 VTAAGESPQGNEREF 630
Cdd:cd00063   77 VNGGGESPPSESVTV 91
fn3 pfam00041
Fibronectin type III domain;
242-325 6.55e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.79  E-value: 6.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677  242 PPWDIRinFLNASGSRCTLQWE--DEGQVVLN--RLRYQPLNSTS-WNMVNATNAKGRYDLQDLRPFTEYEFQISSklhL 316
Cdd:pfam00041   2 APSNLT--VTDVTSTSLTVSWTppPDGNGPITgyEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQA---V 76


                  ....*....
gi 300795677  317 SQGSWSNWS 325
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 240-319 8.09e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 8.09e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677   240 PLPPWDIRInfLNASGSRCTLQWE--DEGQVVLNRLRYQPLN---STSWNMVNATNAKGRYDLQDLRPFTEYEFQISSKL 314
Cdd:smart00060   1 PSPPSNLRV--TDVTSTSVTLSWEppPDDGITGYIVGYRVEYreeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                   ....*
gi 300795677   315 HLSQG 319
Cdd:smart00060  79 GAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 536-622 1.67e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 1.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677   536 PLSGPHITAITekKESLFISWTHIPFLEQRGCILHYRIYWKERHSTAQpelcEIQYRHSQNSHPISSLQPKVTYVLWMTA 615
Cdd:smart00060   3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWK----EVNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 300795677   616 VTAAGES 622
Cdd:smart00060  77 VNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
536-623 1.54e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 1.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677  536 PLSGPHITAITEKkeSLFISWTHIPflEQRGCILHYRI-YWKERHSTAQPElceIQYRHSQNSHPISSLQPKVTYVLWMT 614
Cdd:pfam00041   2 APSNLTVTDVTST--SLTVSWTPPP--DGNGPITGYEVeYRPKNSGEPWNE---ITVPGTTTSVTLTGLKPGTEYEVRVQ 74


                  ....*....
gi 300795677  615 AVTAAGESP 623
Cdd:pfam00041  75 AVNGGGEGP 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
407-627 3.75e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.22  E-value: 3.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677 407 AWTASVSAANSKGTSAPTHINIVDLCGTGFLAPHQVSAKSGNMDNIMVTWQPPGKADsvIREYIVEWRALQQGSvmnltp 486
Cdd:COG3401  204 TYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGDGP------ 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677 487 hWLRIPPYNMSALISEKIKP---YiCYEIRVHALSEDQGGCSSIRGDSSHKVPLSGP---HITAITEKKESLfiSWTHIP 560
Cdd:COG3401  276 -FTKVATVTTTSYTDTGLTNgttY-YYRVTAVDAAGNESAPSNVVSVTTDLTPPAAPsglTATAVGSSSITL--SWTASS 351

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300795677 561 fleqRGCILHYRIYWKERHSTAQPELCEIQyrhSQNSHPISSLQPKVTYVLWMTAVTAAG-ESPQGNE 627
Cdd:COG3401  352 ----DADVTGYNVYRSTSGGGTYTKIAETV---TTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEE 412
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 438-523 3.39e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.21  E-value: 3.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677   438 APHQVSAKSGNMDNIMVTWQPPgkADSVIREYIVEWRALQQGSvmnlTPHWLRIP-PYNMSALISEKIKPYICYEIRVHA 516
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPP--PDDGITGYIVGYRVEYREE----GSEWKEVNvTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 300795677   517 LSEDQGG 523
Cdd:smart00060  77 VNGAGEG 83
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 28-120 2.92e-16

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 74.59  E-value: 2.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677   28 CKLGTVTVqPAPVIPLGSTANISCSLNPKQgCSHYPSYNELILLKFVNdvlvEKLHGKKVHGHPSHSSIFQVTNLSLGMT 107
Cdd:pfam06328   1 EPCGHISP-SPPVVRLGSNVTASCILKENC-CSHLGVEAQIIVWKLGL----ELIPGSQYTVLNDTVSSVTLPNLNSTRA 74

                          90
                  ....*....|...
gi 300795677  108 LFVCKLNCSNSQK 120
Cdd:pfam06328  75 LLTCCLLWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 240-332 3.45e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.51  E-value: 3.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677 240 PLPPWDIRINflNASGSRCTLQWE----DEGQVVLNRLRYQPLNSTSWNMVNATNAKG-RYDLQDLRPFTEYEFQISSKl 314
Cdd:cd00063    1 PSPPTNLRVT--DVTSTSVTLSWTppedDGGPITGYVVEYREKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAV- 77

                         90
                 ....*....|....*...
gi 300795677 315 hlSQGSWSNWSESLRTRT 332
Cdd:cd00063   78 --NGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
438-526 4.91e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 51.26  E-value: 4.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677  438 APHQVSAKSGNMDNIMVTWQPPGKADSVIREYIVEWRALQQGSVmnltPHWLRIPPYNMSALISeKIKPYICYEIRVHAL 517
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEP----WNEITVPGTTTSVTLT-GLKPGTEYEVRVQAV 76


                  ....*....
gi 300795677  518 SEDQGGCSS 526
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 438-526 5.18e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 5.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677 438 APHQVSAKSGNMDNIMVTWQPPGKADSVIREYIVEWRALQQGSVMNLTPHWLRIPPYNMSALisekiKPYICYEIRVHAL 517
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGL-----KPGTEYEFRVRAV 77


                 ....*....
gi 300795677 518 SEDQGGCSS 526
Cdd:cd00063   78 NGGGESPPS 86
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 536-630 6.42e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 6.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677 536 PLSGPHITAITekKESLFISWThiPFLEQRGCILHYRIYWKERHSTaQPELCEIQyRHSQNSHPISSLQPKVTYVLWMTA 615
Cdd:cd00063    3 PPTNLRVTDVT--STSVTLSWT--PPEDDGGPITGYVVEYREKGSG-DWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRA 76

                         90
                 ....*....|....*
gi 300795677 616 VTAAGESPQGNEREF 630
Cdd:cd00063   77 VNGGGESPPSESVTV 91
fn3 pfam00041
Fibronectin type III domain;
242-325 6.55e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.79  E-value: 6.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677  242 PPWDIRinFLNASGSRCTLQWE--DEGQVVLN--RLRYQPLNSTS-WNMVNATNAKGRYDLQDLRPFTEYEFQISSklhL 316
Cdd:pfam00041   2 APSNLT--VTDVTSTSLTVSWTppPDGNGPITgyEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQA---V 76


                  ....*....
gi 300795677  317 SQGSWSNWS 325
Cdd:pfam00041  77 NGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 240-319 8.09e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 8.09e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677   240 PLPPWDIRInfLNASGSRCTLQWE--DEGQVVLNRLRYQPLN---STSWNMVNATNAKGRYDLQDLRPFTEYEFQISSKL 314
Cdd:smart00060   1 PSPPSNLRV--TDVTSTSVTLSWEppPDDGITGYIVGYRVEYreeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                   ....*
gi 300795677   315 HLSQG 319
Cdd:smart00060  79 GAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 536-622 1.67e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 1.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677   536 PLSGPHITAITekKESLFISWTHIPFLEQRGCILHYRIYWKERHSTAQpelcEIQYRHSQNSHPISSLQPKVTYVLWMTA 615
Cdd:smart00060   3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWK----EVNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 300795677   616 VTAAGES 622
Cdd:smart00060  77 VNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
536-623 1.54e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 1.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677  536 PLSGPHITAITEKkeSLFISWTHIPflEQRGCILHYRI-YWKERHSTAQPElceIQYRHSQNSHPISSLQPKVTYVLWMT 614
Cdd:pfam00041   2 APSNLTVTDVTST--SLTVSWTPPP--DGNGPITGYEVeYRPKNSGEPWNE---ITVPGTTTSVTLTGLKPGTEYEVRVQ 74


                  ....*....
gi 300795677  615 AVTAAGESP 623
Cdd:pfam00041  75 AVNGGGEGP 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
407-627 3.75e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.22  E-value: 3.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677 407 AWTASVSAANSKGTSAPTHINIVDLCGTGFLAPHQVSAKSGNMDNIMVTWQPPGKADsvIREYIVEWRALQQGSvmnltp 486
Cdd:COG3401  204 TYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGDGP------ 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677 487 hWLRIPPYNMSALISEKIKP---YiCYEIRVHALSEDQGGCSSIRGDSSHKVPLSGP---HITAITEKKESLfiSWTHIP 560
Cdd:COG3401  276 -FTKVATVTTTSYTDTGLTNgttY-YYRVTAVDAAGNESAPSNVVSVTTDLTPPAAPsglTATAVGSSSITL--SWTASS 351

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300795677 561 fleqRGCILHYRIYWKERHSTAQPELCEIQyrhSQNSHPISSLQPKVTYVLWMTAVTAAG-ESPQGNE 627
Cdd:COG3401  352 ----DADVTGYNVYRSTSGGGTYTKIAETV---TTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEE 412
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 438-523 3.39e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.21  E-value: 3.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795677   438 APHQVSAKSGNMDNIMVTWQPPgkADSVIREYIVEWRALQQGSvmnlTPHWLRIP-PYNMSALISEKIKPYICYEIRVHA 516
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPP--PDDGITGYIVGYRVEYREE----GSEWKEVNvTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 300795677   517 LSEDQGG 523
Cdd:smart00060  77 VNGAGEG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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