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Conserved domains on  [gi|299473771|ref|NP_001177396|]
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proline-rich protein 36 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
205-728 9.37e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.89  E-value: 9.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  205 PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA------PAHPSQPKPKGLQ 278
Cdd:PHA03247 2575 PRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAnepdphPPPTVPPPERPRD 2654
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  279 ALRPPQVTPPRKDAAPALGPLSSSPLATPSPsgtkaRPVPPPDNAATPLPATLPPSPPVTPPPPAALQSQAPPTLPATPH 358
Cdd:PHA03247 2655 DPAPGRVSRPRRARRLGRAAQASSPPQRPRR-----RAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAAR 2729
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  359 SSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPAT--PPSQVPPTQlimsfPEAGVSSLATAAFVASVSPSVssplqsmpP 436
Cdd:PHA03247 2730 QASPALPAAPAPPAVPAGPATPGGPARPARPPTTagPPAPAPPAA-----PAAGPPRRLTRPAVASLSESR--------E 2796
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  437 TQANPALPSLPTLLSPLATPPLSAMSPLQGPVSPATSLGNSAFPLAALPQPGLSALTTPPPQASPSPSPPSLQATPHTLA 516
Cdd:PHA03247 2797 SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPA 2876
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  517 TLPLQDSPLLATLPLQASPSPLTTVSLQDPPLVSPSLLASPplqapphpqappsMTTPPMQAPPSLQTIPPIQvphslTS 596
Cdd:PHA03247 2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP-------------QPQPQPPPPPQPQPPPPPP-----PR 2938
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  597 PSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRqTQASLISPSRPASTPPDSPPLQAPLSLPAS--PPLQTSLSP 674
Cdd:PHA03247 2939 PQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPR-FRVPQPAPSREAPASSTPPLTGHSLSRVSSwaSSLALHEET 3017
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  675 AVSPLSSPLTIHP------LQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPAS 728
Cdd:PHA03247 3018 DPPPVSLKQTLWPpddtedSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEA 3077
DUF4596 pfam15363
Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is ...
1304-1346 6.04e-10

Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.


:

Pssm-ID: 464673  Cd Length: 46  Bit Score: 55.70  E-value: 6.04e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 299473771  1304 RWAELLSPLDESRASITsVTSFSPDDVASPQGDWTVVEVETFH 1346
Cdd:pfam15363    5 RWSELSSPLDDSSASIT-VTSFSPEDGCSPQGEWTILELETQH 46
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
57-326 5.43e-07

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 54.41  E-value: 5.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771   57 PLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGqkgLRI 136
Cdd:PHA03307  100 PAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAA---LPL 176
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  137 SAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHS 216
Cdd:PHA03307  177 SSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECP 256
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  217 TTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAL 296
Cdd:PHA03307  257 LPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESS 336
                         250       260       270
                  ....*....|....*....|....*....|
gi 299473771  297 GPLSSSPLATPSPSGTKARPVPPPDNAATP 326
Cdd:PHA03307  337 RGAAVSPGPSPSRSPSPSRPPPPADPSSPR 366
PHA03247 super family cl33720
large tegument protein UL36; Provisional
646-1094 4.11e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 4.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  646 PASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSP---------LTIHPLQALSSLASHSPQAPLSSLIMPPLETQSS 716
Cdd:PHA03247 2489 PFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVgepvhprmlTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSV 2568
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  717 LAP--------PSLQTPPASLTTPPLENLP------------SLAPPPLQTASAPLTTPPLENLPSLAPPPLQTASAPLT 776
Cdd:PHA03247 2569 PPPrpaprpsePAVTSRARRPDAPPQSARPrapvddrgdprgPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPP 2648
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  777 TPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPALALPPLQAPP 856
Cdd:PHA03247 2649 PERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAA 2728
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  857 SPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP 936
Cdd:PHA03247 2729 RQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPP 2808
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  937 PMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALAT 1016
Cdd:PHA03247 2809 AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLAR 2888
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 299473771 1017 PPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVP-PSPPASPTlqaPRRPPTPGPDTSVSGPRL 1094
Cdd:PHA03247 2889 PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPrPQPPLAPT---TDPAGAGEPSGAVPQPWL 2964
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
1026-1237 4.73e-04

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 44.48  E-value: 4.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771 1026 PASFPGQAPFSPSASLPMSplATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPP 1105
Cdd:PRK12323  365 PGQSGGGAGPATAAAAPVA--QPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASAR 442
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771 1106 PSRSPSSTLSGPdlaghssSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPA 1185
Cdd:PRK12323  443 GPGGAPAPAPAP-------AAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPD 515
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 299473771 1186 TGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSR 1237
Cdd:PRK12323  516 AAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPR 567
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
205-728 9.37e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.89  E-value: 9.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  205 PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA------PAHPSQPKPKGLQ 278
Cdd:PHA03247 2575 PRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAnepdphPPPTVPPPERPRD 2654
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  279 ALRPPQVTPPRKDAAPALGPLSSSPLATPSPsgtkaRPVPPPDNAATPLPATLPPSPPVTPPPPAALQSQAPPTLPATPH 358
Cdd:PHA03247 2655 DPAPGRVSRPRRARRLGRAAQASSPPQRPRR-----RAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAAR 2729
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  359 SSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPAT--PPSQVPPTQlimsfPEAGVSSLATAAFVASVSPSVssplqsmpP 436
Cdd:PHA03247 2730 QASPALPAAPAPPAVPAGPATPGGPARPARPPTTagPPAPAPPAA-----PAAGPPRRLTRPAVASLSESR--------E 2796
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  437 TQANPALPSLPTLLSPLATPPLSAMSPLQGPVSPATSLGNSAFPLAALPQPGLSALTTPPPQASPSPSPPSLQATPHTLA 516
Cdd:PHA03247 2797 SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPA 2876
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  517 TLPLQDSPLLATLPLQASPSPLTTVSLQDPPLVSPSLLASPplqapphpqappsMTTPPMQAPPSLQTIPPIQvphslTS 596
Cdd:PHA03247 2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP-------------QPQPQPPPPPQPQPPPPPP-----PR 2938
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  597 PSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRqTQASLISPSRPASTPPDSPPLQAPLSLPAS--PPLQTSLSP 674
Cdd:PHA03247 2939 PQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPR-FRVPQPAPSREAPASSTPPLTGHSLSRVSSwaSSLALHEET 3017
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  675 AVSPLSSPLTIHP------LQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPAS 728
Cdd:PHA03247 3018 DPPPVSLKQTLWPpddtedSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEA 3077
DUF4596 pfam15363
Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is ...
1304-1346 6.04e-10

Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.


Pssm-ID: 464673  Cd Length: 46  Bit Score: 55.70  E-value: 6.04e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 299473771  1304 RWAELLSPLDESRASITsVTSFSPDDVASPQGDWTVVEVETFH 1346
Cdd:pfam15363    5 RWSELSSPLDDSSASIT-VTSFSPEDGCSPQGEWTILELETQH 46
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
57-326 5.43e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 54.41  E-value: 5.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771   57 PLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGqkgLRI 136
Cdd:PHA03307  100 PAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAA---LPL 176
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  137 SAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHS 216
Cdd:PHA03307  177 SSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECP 256
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  217 TTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAL 296
Cdd:PHA03307  257 LPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESS 336
                         250       260       270
                  ....*....|....*....|....*....|
gi 299473771  297 GPLSSSPLATPSPSGTKARPVPPPDNAATP 326
Cdd:PHA03307  337 RGAAVSPGPSPSRSPSPSRPPPPADPSSPR 366
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
386-776 7.92e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.45  E-value: 7.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771   386 LPSPPATPPSQVPPTQLIMSFPEAGVSSLATAAFVASVSPSVSSPLQSMPPTQANPALPSLPTLLSPLATPPLSAMSPLQ 465
Cdd:pfam03154  174 LQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMT 253
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771   466 GPVSPatslgnSAFPLAALPQPGLSALTTPPPQASPSPSPPslqaTPHTLATLPLQDSPLLATLPLQASPSPLTTVSLQD 545
Cdd:pfam03154  254 QPPPP------SQVSPQPLPQPSLHGQMPPMPHSLQTGPSH----MQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQ 323
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771   546 PPLVSPSLLASPPLQAPPHPQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATtslgSPTLQAT 625
Cdd:pfam03154  324 RIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPP----PPALKPL 399
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771   626 HSFLTMSPRQTQASlispsrPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSS 705
Cdd:pfam03154  400 SSLSTHHPPSAHPP------PLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPP 473
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 299473771   706 LIMPPLETQSSLAP--PSLQTP--PASLTTPPLENLPSLAPPPLQTASAPLTTPpleNLPSLAPPPLQTASAPLT 776
Cdd:pfam03154  474 PITPPSGPPTSTSSamPGIQPPssASVSSSGPVPAAVSCPLPPVQIKEEALDEA---EEPESPPPPPRSPSPEPT 545
PHA03247 PHA03247
large tegument protein UL36; Provisional
646-1094 4.11e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 4.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  646 PASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSP---------LTIHPLQALSSLASHSPQAPLSSLIMPPLETQSS 716
Cdd:PHA03247 2489 PFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVgepvhprmlTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSV 2568
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  717 LAP--------PSLQTPPASLTTPPLENLP------------SLAPPPLQTASAPLTTPPLENLPSLAPPPLQTASAPLT 776
Cdd:PHA03247 2569 PPPrpaprpsePAVTSRARRPDAPPQSARPrapvddrgdprgPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPP 2648
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  777 TPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPALALPPLQAPP 856
Cdd:PHA03247 2649 PERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAA 2728
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  857 SPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP 936
Cdd:PHA03247 2729 RQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPP 2808
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  937 PMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALAT 1016
Cdd:PHA03247 2809 AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLAR 2888
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 299473771 1017 PPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVP-PSPPASPTlqaPRRPPTPGPDTSVSGPRL 1094
Cdd:PHA03247 2889 PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPrPQPPLAPT---TDPAGAGEPSGAVPQPWL 2964
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1026-1237 4.73e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.48  E-value: 4.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771 1026 PASFPGQAPFSPSASLPMSplATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPP 1105
Cdd:PRK12323  365 PGQSGGGAGPATAAAAPVA--QPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASAR 442
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771 1106 PSRSPSSTLSGPdlaghssSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPA 1185
Cdd:PRK12323  443 GPGGAPAPAPAP-------AAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPD 515
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 299473771 1186 TGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSR 1237
Cdd:PRK12323  516 AAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPR 567
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
574-700 3.17e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 41.72  E-value: 3.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771   574 PPMQAPPSLQTIPPIQVPHSL--TSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLT-MSPRQTQASLispSRPASTP 650
Cdd:TIGR01628  380 PRMRQLPMGSPMGGAMGQPPYygQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLRPNGLApMNAVRAPSRN---AQNAAQK 456
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 299473771   651 PDSPPLQAP---LSLPASPPLQTSLSPAVSPLSSPLTIhplqalSSLASHSPQ 700
Cdd:TIGR01628  457 PPMQPVMYPpnyQSLPLSQDLPQPQSTASQGGQNKKLA------QVLASATPQ 503
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
205-728 9.37e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.89  E-value: 9.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  205 PRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA------PAHPSQPKPKGLQ 278
Cdd:PHA03247 2575 PRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAnepdphPPPTVPPPERPRD 2654
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  279 ALRPPQVTPPRKDAAPALGPLSSSPLATPSPsgtkaRPVPPPDNAATPLPATLPPSPPVTPPPPAALQSQAPPTLPATPH 358
Cdd:PHA03247 2655 DPAPGRVSRPRRARRLGRAAQASSPPQRPRR-----RAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAAR 2729
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  359 SSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPAT--PPSQVPPTQlimsfPEAGVSSLATAAFVASVSPSVssplqsmpP 436
Cdd:PHA03247 2730 QASPALPAAPAPPAVPAGPATPGGPARPARPPTTagPPAPAPPAA-----PAAGPPRRLTRPAVASLSESR--------E 2796
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  437 TQANPALPSLPTLLSPLATPPLSAMSPLQGPVSPATSLGNSAFPLAALPQPGLSALTTPPPQASPSPSPPSLQATPHTLA 516
Cdd:PHA03247 2797 SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPA 2876
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  517 TLPLQDSPLLATLPLQASPSPLTTVSLQDPPLVSPSLLASPplqapphpqappsMTTPPMQAPPSLQTIPPIQvphslTS 596
Cdd:PHA03247 2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP-------------QPQPQPPPPPQPQPPPPPP-----PR 2938
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  597 PSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRqTQASLISPSRPASTPPDSPPLQAPLSLPAS--PPLQTSLSP 674
Cdd:PHA03247 2939 PQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPR-FRVPQPAPSREAPASSTPPLTGHSLSRVSSwaSSLALHEET 3017
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  675 AVSPLSSPLTIHP------LQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPAS 728
Cdd:PHA03247 3018 DPPPVSLKQTLWPpddtedSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEA 3077
DUF4596 pfam15363
Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is ...
1304-1346 6.04e-10

Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.


Pssm-ID: 464673  Cd Length: 46  Bit Score: 55.70  E-value: 6.04e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 299473771  1304 RWAELLSPLDESRASITsVTSFSPDDVASPQGDWTVVEVETFH 1346
Cdd:pfam15363    5 RWSELSSPLDDSSASIT-VTSFSPEDGCSPQGEWTILELETQH 46
PHA03247 PHA03247
large tegument protein UL36; Provisional
24-492 2.47e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.18  E-value: 2.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771   24 LLTPRPPGSPRPPPPVtpaalrvlgaAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGER- 102
Cdd:PHA03247 2519 ILPDEPVGEPVHPRML----------TWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARr 2588
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  103 --APPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGAR-RDTSGPTPGTPSPAMARR 179
Cdd:PHA03247 2589 pdAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPeRPRDDPAPGRVSRPRRAR 2668
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  180 SRAAGTEVGLPRPAPSARPRPPTEGPrksVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSS-----ATPLSSPAR 254
Cdd:PHA03247 2669 RLGRAAQASSPPQRPRRRAARPTVGS---LTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQAspalpAAPAPPAVP 2745
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  255 SGPSARGTPRAPAHPSQPK-PKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGtkarPVPPPDNAATPLPATLPP 333
Cdd:PHA03247 2746 AGPATPGGPARPARPPTTAgPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD----PADPPAAVLAPAAALPPA 2821
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  334 SPPVTPPPPAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQvpptqlimSFPEAGVSS 413
Cdd:PHA03247 2822 ASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVR--------RLARPAVSR 2893
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 299473771  414 LATAAFVASVSPSVSSPLQSMPPTQANPALPSLPTLLSPLATPPLSamsplQGPVSPATSLGNSAFPLAALPQPGLSAL 492
Cdd:PHA03247 2894 STESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRP-----QPPLAPTTDPAGAGEPSGAVPQPWLGAL 2967
PHA03247 PHA03247
large tegument protein UL36; Provisional
49-474 7.82e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.26  E-value: 7.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771   49 AAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGP 128
Cdd:PHA03247 2581 AVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGR 2660
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  129 LGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKS 208
Cdd:PHA03247 2661 VSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPA 2740
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  209 VSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGT------PRAPAHPSQPKPKGLQAL-- 280
Cdd:PHA03247 2741 PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESreslpsPWDPADPPAAVLAPAAALpp 2820
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  281 --RPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARP-----VPPPDNAATPLPATLPPSPPVTPPPPAALQSQAPPTL 353
Cdd:PHA03247 2821 aaSPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvrRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAL 2900
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  354 PATPHSSSLTCQLATpLPLAPPSPSAPPSLQTLPSPPATPPSQVPPTqlimsfPEAGVSSLATAAFVASVSPSVSSPLQS 433
Cdd:PHA03247 2901 PPDQPERPPQPQAPP-PPQPQPQPPPPPQPQPPPPPPPRPQPPLAPT------TDPAGAGEPSGAVPQPWLGALVPGRVA 2973
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 299473771  434 MPPTQANPALPSLPTllsPLATPPLSAMSPLQGPVSPATSL 474
Cdd:PHA03247 2974 VPRFRVPQPAPSREA---PASSTPPLTGHSLSRVSSWASSL 3011
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
57-326 5.43e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 54.41  E-value: 5.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771   57 PLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGqkgLRI 136
Cdd:PHA03307  100 PAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAA---LPL 176
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  137 SAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHS 216
Cdd:PHA03307  177 SSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECP 256
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  217 TTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAL 296
Cdd:PHA03307  257 LPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESS 336
                         250       260       270
                  ....*....|....*....|....*....|
gi 299473771  297 GPLSSSPLATPSPSGTKARPVPPPDNAATP 326
Cdd:PHA03307  337 RGAAVSPGPSPSRSPSPSRPPPPADPSSPR 366
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
386-776 7.92e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.45  E-value: 7.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771   386 LPSPPATPPSQVPPTQLIMSFPEAGVSSLATAAFVASVSPSVSSPLQSMPPTQANPALPSLPTLLSPLATPPLSAMSPLQ 465
Cdd:pfam03154  174 LQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMT 253
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771   466 GPVSPatslgnSAFPLAALPQPGLSALTTPPPQASPSPSPPslqaTPHTLATLPLQDSPLLATLPLQASPSPLTTVSLQD 545
Cdd:pfam03154  254 QPPPP------SQVSPQPLPQPSLHGQMPPMPHSLQTGPSH----MQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQ 323
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771   546 PPLVSPSLLASPPLQAPPHPQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATtslgSPTLQAT 625
Cdd:pfam03154  324 RIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPP----PPALKPL 399
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771   626 HSFLTMSPRQTQASlispsrPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSS 705
Cdd:pfam03154  400 SSLSTHHPPSAHPP------PLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPP 473
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 299473771   706 LIMPPLETQSSLAP--PSLQTP--PASLTTPPLENLPSLAPPPLQTASAPLTTPpleNLPSLAPPPLQTASAPLT 776
Cdd:pfam03154  474 PITPPSGPPTSTSSamPGIQPPssASVSSSGPVPAAVSCPLPPVQIKEEALDEA---EEPESPPPPPRSPSPEPT 545
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
116-331 1.83e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.13  E-value: 1.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  116 SPGRASGTTRPGPlgQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPS 195
Cdd:PRK07764  591 APGAAGGEGPPAP--ASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDG 668
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  196 ARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPK 275
Cdd:PRK07764  669 WPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDP 748
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 299473771  276 GLQALRPPQVTPPRKDAAPAlgplssSPLATPSPSGTKARPVPPPDNAATPLPATL 331
Cdd:PRK07764  749 PDPAGAPAQPPPPPAPAPAA------APAAAPPPSPPSEEEEMAEDDAPSMDDEDR 798
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
49-320 3.89e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.84  E-value: 3.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771   49 AAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGP 128
Cdd:PRK07003  386 RAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDE 465
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  129 LGQkglrisaeetvargkatEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKS 208
Cdd:PRK07003  466 RDA-----------------QPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPP 528
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  209 VSSAsehstTEPSPAARRRPSAGGGLQrpASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPkglqALRPPQVTPP 288
Cdd:PRK07003  529 APEA-----RPPTPAAAAPAARAGGAA--AALDVLRNAGMRVSSDRGARAAAAAKPAAAPAAAPKP----AAPRVAVQVP 597
                         250       260       270
                  ....*....|....*....|....*....|..
gi 299473771  289 RKdAAPALGPLSSSPLATPSPSGTKARPVPPP 320
Cdd:PRK07003  598 TP-RARAATGDAPPNGAARAEQAAESRGAPPP 628
PHA03247 PHA03247
large tegument protein UL36; Provisional
646-1094 4.11e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 4.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  646 PASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSP---------LTIHPLQALSSLASHSPQAPLSSLIMPPLETQSS 716
Cdd:PHA03247 2489 PFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVgepvhprmlTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSV 2568
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  717 LAP--------PSLQTPPASLTTPPLENLP------------SLAPPPLQTASAPLTTPPLENLPSLAPPPLQTASAPLT 776
Cdd:PHA03247 2569 PPPrpaprpsePAVTSRARRPDAPPQSARPrapvddrgdprgPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPP 2648
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  777 TPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPALALPPLQAPP 856
Cdd:PHA03247 2649 PERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAA 2728
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  857 SPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP 936
Cdd:PHA03247 2729 RQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPP 2808
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  937 PMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALAT 1016
Cdd:PHA03247 2809 AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLAR 2888
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 299473771 1017 PPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVP-PSPPASPTlqaPRRPPTPGPDTSVSGPRL 1094
Cdd:PHA03247 2889 PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPrPQPPLAPT---TDPAGAGEPSGAVPQPWL 2964
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1026-1237 4.73e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.48  E-value: 4.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771 1026 PASFPGQAPFSPSASLPMSplATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPP 1105
Cdd:PRK12323  365 PGQSGGGAGPATAAAAPVA--QPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASAR 442
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771 1106 PSRSPSSTLSGPdlaghssSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPA 1185
Cdd:PRK12323  443 GPGGAPAPAPAP-------AAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPD 515
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 299473771 1186 TGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSR 1237
Cdd:PRK12323  516 AAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPR 567
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
48-399 7.60e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 7.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771   48 GAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPG 127
Cdd:PRK07764  370 DERGLLARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAP 449
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  128 PLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRK 207
Cdd:PRK07764  450 AGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRERWPEILAAVPKRSRK 529
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  208 SVSSASEHST-----------TEPSPAARRRPSAGG-------------GLQRPASRSLSSSATPLSSPARSGPSARGTP 263
Cdd:PRK07764  530 TWAILLPEATvlgvrgdtlvlGFSTGGLARRFASPGnaevlvtalaeelGGDWQVEAVVGPAPGAAGGEGPPAPASSGPP 609
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  264 RAPAHPSQPKPKGlqalRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPVTPPPPA 343
Cdd:PRK07764  610 EEAARPAAPAAPA----APAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAP 685
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 299473771  344 ALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQVPP 399
Cdd:PRK07764  686 APAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPL 741
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
237-330 9.11e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 43.73  E-value: 9.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  237 PASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPAlgPLSSSPLATPSPSGTKARP 316
Cdd:PRK12270   27 PSWREFFADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPK--PAAAAAAAAAPAAPPAAAA 104
                          90
                  ....*....|....
gi 299473771  317 VPPPDNAATPLPAT 330
Cdd:PRK12270  105 AAAPAAAAVEDEVT 118
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
629-788 2.69e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 42.16  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  629 LTMSPRQTQASLISPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSlim 708
Cdd:PRK07994  357 LAFHPAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQ--- 433
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  709 PPLETQSSLAPPSLQTPPASlttPPLENLPSLAPPPLQTASAPlttPPLENLPSLAPPPLQTASAPLTTP--------HL 780
Cdd:PRK07994  434 GATKAKKSEPAAASRARPVN---SALERLASVRPAPSALEKAP---AKKEAYRWKATNPVEVKKEPVATPkalkkaleHE 507

                  ....*...
gi 299473771  781 ETPPCPAP 788
Cdd:PRK07994  508 KTPELAAK 515
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
974-1183 2.92e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 2.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  974 TPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPfsPSASLPMSPLATPPPQA 1053
Cdd:PRK12323  385 PAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPG--GAPAPAPAPAAAPAAAA 462
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771 1054 PPVlAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPpsrspsstlSGPDLAGHSSSATSTPEEL 1133
Cdd:PRK12323  463 RPA-AAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQ---------PDAAPAGWVAESIPDPATA 532
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 299473771 1134 RGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWP 1183
Cdd:PRK12323  533 DPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWP 582
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
574-700 3.17e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 41.72  E-value: 3.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771   574 PPMQAPPSLQTIPPIQVPHSL--TSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLT-MSPRQTQASLispSRPASTP 650
Cdd:TIGR01628  380 PRMRQLPMGSPMGGAMGQPPYygQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLRPNGLApMNAVRAPSRN---AQNAAQK 456
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 299473771   651 PDSPPLQAP---LSLPASPPLQTSLSPAVSPLSSPLTIhplqalSSLASHSPQ 700
Cdd:TIGR01628  457 PPMQPVMYPpnyQSLPLSQDLPQPQSTASQGGQNKKLA------QVLASATPQ 503
PHA03247 PHA03247
large tegument protein UL36; Provisional
913-1244 3.39e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 3.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  913 PPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPP 992
Cdd:PHA03247 2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPP 2705
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  993 SPPASLPMSPLAKPPPQAPPALATPPLQALPSPPA--------SFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQV 1064
Cdd:PHA03247 2706 PTPEPAPHALVSATPLPPGPAAARQASPALPAAPAppavpagpATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR 2785
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771 1065 PPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGP--EG 1142
Cdd:PHA03247 2786 PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDvrRR 2865
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771 1143 GAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTS 1222
Cdd:PHA03247 2866 PPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAP 2945
                         330       340
                  ....*....|....*....|..
gi 299473771 1223 GGKAAAGAGAGASSRSPKQARL 1244
Cdd:PHA03247 2946 TTDPAGAGEPSGAVPQPWLGAL 2967
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
188-396 4.46e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 4.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  188 GLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPA 267
Cdd:PRK12323  370 GGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPA 449
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  268 HPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSgtkARPVPPPDNaatpLPATLPPSPPVTPPPPAALQS 347
Cdd:PRK12323  450 PAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPA---DDDPPPWEE----LPPEFASPAPAQPDAAPAGWV 522
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 299473771  348 QAPPTLPATPHSSSltcQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQ 396
Cdd:PRK12323  523 AESIPDPATADPDD---AFETLAPAPAAAPAPRAAAATEPVVAPRPPRA 568
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1042-1239 6.06e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 6.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771 1042 PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPsrspsstlsgpdlag 1121
Cdd:PRK12323  374 PATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQ--------------- 438
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771 1122 hsssatstpeelrgydSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETE 1201
Cdd:PRK12323  439 ----------------ASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEEL 502
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 299473771 1202 GPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSP 1239
Cdd:PRK12323  503 PPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFET 540
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
58-287 6.16e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 6.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771   58 LAERAGGIGGATIPESAPrAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPlgqkglris 137
Cdd:PRK12323  361 LAFRPGQSGGGAGPATAA-AAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAP--------- 430
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  138 aeETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHST 217
Cdd:PRK12323  431 --EALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFAS 508
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  218 TEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTP 287
Cdd:PRK12323  509 PAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFD 578
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
1047-1246 6.55e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 6.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771 1047 ATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSA 1126
Cdd:PRK07764  597 GEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGA 676
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771 1127 TSTPEELRGYDSGPEGGAAASPPPDAelaachPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGlcTIYETEGPESA 1206
Cdd:PRK07764  677 APAAPPPAPAPAAPAAPAGAAPAQPA------PAPAATPPAGQADDPAAQPPQAAQGASAPSPAADD--PVPLPPEPDDP 748
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 299473771 1207 TPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGE 1246
Cdd:PRK07764  749 PDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAED 788
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
235-318 7.10e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.03  E-value: 7.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473771  235 QRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKA 314
Cdd:PRK12270   36 YGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115

                  ....
gi 299473771  315 RPVP 318
Cdd:PRK12270  116 EVTP 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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