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Conserved domains on  [gi|296080783|ref|NP_001171680|]
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zinc finger protein 408 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 45-168 4.04e-54

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


:

Pssm-ID: 380918  Cd Length: 121  Bit Score: 181.46  E-value: 4.04e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080783  45 ALKSLPRGLALGPSLAKEQRLGVWCVGDPLQPGLLWGPLEEESASKEKGEGVKPRQEEnlsLGPWGDVCACEQSSGWTSL 124
Cdd:cd10520    1 ALRSLPPGLALGPSLAQEERLGVWCVGDALQKGTFLGPLEEELESHDLTEGGSPRQEE---SGQSGDVLACEQSSKWMRF 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 296080783 125 VQRGRLESEGNVAPVRISERLHLQVYQLVLPGSELLLWPQPSSE 168
Cdd:cd10520   78 ACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLWPEENGA 121
zf-H2C2_2 pfam13465
Zinc-finger double domain;
474-499 1.85e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.67  E-value: 1.85e-06
                          10        20
                  ....*....|....*....|....*.
gi 296080783  474 SLRNHMRLHTGEKPFLCPHCGRAFRQ 499
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-508 5.43e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 5.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080783 300 KLHSPSDQCPP--RAKTPEPGAQQSGFPTLSRSPPGPAGSSPKQGR--RYRCGECGKAFLQLCHLKKH--AFVHTG--HK 371
Cdd:COG5048  241 LSQSPSSLSSSdsSSSASESPRSSLPTASSQSSSPNESDSSSEKGFslPIKSKQCNISFSRSSPLTRHlrSVNHSGesLK 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080783 372 PFLCTE--CGKSYSSEESFKAHMLGHRGVRPFPCP---------QCDKAYGTQRDLKEHQVVHSgaRPFACD--QCGKAF 438
Cdd:COG5048  321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllnssskfsPLLNNEPPQSLQQYKDLKND--KKSETLsnSCIRNF 398

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 296080783 439 ARRPSLRLHRKTH-QVPAAPAPCPCPVCGRPLANqgSLRNHMRLHTgEKPFLCPHCGRAFRQRGNLRGHLR 508
Cdd:COG5048  399 KRDSNLSLHIITHlSFRPYNCKNPPCSKSFNRHY--NLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
467-621 7.74e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 7.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080783 467 RPLANQGSLRNHMR--LHTGE--KPFLCPH--CGRAFRQRGNLRGHLRLHTGERPYRCPhcadafpqlpeLRRHLISHTG 540
Cdd:COG5048  297 ISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK-----------LLNSSSKFSP 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080783 541 EAHLCPVcgkALRDPHTLRAHERLHSGERPFPCPQCGRAYTLATKLRRHLKShlEDKPYRCPTCGMGYTLPQSLRRHQLS 620
Cdd:COG5048  366 LLNNEPP---QSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKI 440


                 .
gi 296080783 621 H 621
Cdd:COG5048  441 H 441
 
Name Accession Description Interval E-value
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 45-168 4.04e-54

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 181.46  E-value: 4.04e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080783  45 ALKSLPRGLALGPSLAKEQRLGVWCVGDPLQPGLLWGPLEEESASKEKGEGVKPRQEEnlsLGPWGDVCACEQSSGWTSL 124
Cdd:cd10520    1 ALRSLPPGLALGPSLAQEERLGVWCVGDALQKGTFLGPLEEELESHDLTEGGSPRQEE---SGQSGDVLACEQSSKWMRF 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 296080783 125 VQRGRLESEGNVAPVRISERLHLQVYQLVLPGSELLLWPQPSSE 168
Cdd:cd10520   78 ACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLWPEENGA 121
zf-H2C2_2 pfam13465
Zinc-finger double domain;
474-499 1.85e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.67  E-value: 1.85e-06
                          10        20
                  ....*....|....*....|....*.
gi 296080783  474 SLRNHMRLHTGEKPFLCPHCGRAFRQ 499
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-508 5.43e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 5.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080783 300 KLHSPSDQCPP--RAKTPEPGAQQSGFPTLSRSPPGPAGSSPKQGR--RYRCGECGKAFLQLCHLKKH--AFVHTG--HK 371
Cdd:COG5048  241 LSQSPSSLSSSdsSSSASESPRSSLPTASSQSSSPNESDSSSEKGFslPIKSKQCNISFSRSSPLTRHlrSVNHSGesLK 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080783 372 PFLCTE--CGKSYSSEESFKAHMLGHRGVRPFPCP---------QCDKAYGTQRDLKEHQVVHSgaRPFACD--QCGKAF 438
Cdd:COG5048  321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllnssskfsPLLNNEPPQSLQQYKDLKND--KKSETLsnSCIRNF 398

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 296080783 439 ARRPSLRLHRKTH-QVPAAPAPCPCPVCGRPLANqgSLRNHMRLHTgEKPFLCPHCGRAFRQRGNLRGHLR 508
Cdd:COG5048  399 KRDSNLSLHIITHlSFRPYNCKNPPCSKSFNRHY--NLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
467-621 7.74e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 7.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080783 467 RPLANQGSLRNHMR--LHTGE--KPFLCPH--CGRAFRQRGNLRGHLRLHTGERPYRCPhcadafpqlpeLRRHLISHTG 540
Cdd:COG5048  297 ISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK-----------LLNSSSKFSP 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080783 541 EAHLCPVcgkALRDPHTLRAHERLHSGERPFPCPQCGRAYTLATKLRRHLKShlEDKPYRCPTCGMGYTLPQSLRRHQLS 620
Cdd:COG5048  366 LLNNEPP---QSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKI 440


                 .
gi 296080783 621 H 621
Cdd:COG5048  441 H 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
502-525 1.73e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.73e-04
                          10        20
                  ....*....|....*....|....
gi 296080783  502 NLRGHLRLHTGERPYRCPHCADAF 525
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
359-384 7.16e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.16e-04
                          10        20
                  ....*....|....*....|....*.
gi 296080783  359 HLKKHAFVHTGHKPFLCTECGKSYSS 384
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 515-561 4.32e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.93  E-value: 4.32e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 296080783 515 PYRCPHCADAFPQLPELRRHlISHTGEAHLCPVCGKALRDPHTLRAH 561
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH-IRYTEHSKVCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 45-168 4.04e-54

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 181.46  E-value: 4.04e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080783  45 ALKSLPRGLALGPSLAKEQRLGVWCVGDPLQPGLLWGPLEEESASKEKGEGVKPRQEEnlsLGPWGDVCACEQSSGWTSL 124
Cdd:cd10520    1 ALRSLPPGLALGPSLAQEERLGVWCVGDALQKGTFLGPLEEELESHDLTEGGSPRQEE---SGQSGDVLACEQSSKWMRF 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 296080783 125 VQRGRLESEGNVAPVRISERLHLQVYQLVLPGSELLLWPQPSSE 168
Cdd:cd10520   78 ACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLWPEENGA 121
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 49-162 1.90e-14

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 68.76  E-value: 1.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080783  49 LPRGLALGPSLAKEQRLGVWCVgDPLQPGLLWGPLEeesaskekgegvkprqeenlslgpwGDVCaceqssgWTSLVQRG 128
Cdd:cd10534    1 LPAGLELVLSSIPEGGLGVFAR-RTIPAGTRFGPLE-------------------------GVVN-------WMRFVRPA 47

                         90       100       110
                 ....*....|....*....|....*....|....
gi 296080783 129 RLESEGNVAPVRISERLHLQVYQLVLPGSELLLW 162
Cdd:cd10534   48 RNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVW 81
zf-H2C2_2 pfam13465
Zinc-finger double domain;
474-499 1.85e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.67  E-value: 1.85e-06
                          10        20
                  ....*....|....*....|....*.
gi 296080783  474 SLRNHMRLHTGEKPFLCPHCGRAFRQ 499
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 46-162 4.44e-06

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 46.28  E-value: 4.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080783  46 LKSLPRGLALGPSLAKEQRLGVWCVgDPLQPGLLWGPLEEEsaSKEKGEGVKPRQEENLSLGPWGDVC--ACEQSSG-WT 122
Cdd:cd19188    1 LMGLPEELELKPSAVDKTRIGVWAK-KSIPKGRKFGPFVGE--KKKRSQVKNNVYMWEIYGPKRGWMCvdASDPTKGnWL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 296080783 123 SLVQRGRLESEGNVAPVRISERLHLQVYQLVLPGSELLLW 162
Cdd:cd19188   78 RYVNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCW 117
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-508 5.43e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 5.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080783 300 KLHSPSDQCPP--RAKTPEPGAQQSGFPTLSRSPPGPAGSSPKQGR--RYRCGECGKAFLQLCHLKKH--AFVHTG--HK 371
Cdd:COG5048  241 LSQSPSSLSSSdsSSSASESPRSSLPTASSQSSSPNESDSSSEKGFslPIKSKQCNISFSRSSPLTRHlrSVNHSGesLK 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080783 372 PFLCTE--CGKSYSSEESFKAHMLGHRGVRPFPCP---------QCDKAYGTQRDLKEHQVVHSgaRPFACD--QCGKAF 438
Cdd:COG5048  321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllnssskfsPLLNNEPPQSLQQYKDLKND--KKSETLsnSCIRNF 398

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 296080783 439 ARRPSLRLHRKTH-QVPAAPAPCPCPVCGRPLANqgSLRNHMRLHTgEKPFLCPHCGRAFRQRGNLRGHLR 508
Cdd:COG5048  399 KRDSNLSLHIITHlSFRPYNCKNPPCSKSFNRHY--NLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
467-621 7.74e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 7.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080783 467 RPLANQGSLRNHMR--LHTGE--KPFLCPH--CGRAFRQRGNLRGHLRLHTGERPYRCPhcadafpqlpeLRRHLISHTG 540
Cdd:COG5048  297 ISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK-----------LLNSSSKFSP 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080783 541 EAHLCPVcgkALRDPHTLRAHERLHSGERPFPCPQCGRAYTLATKLRRHLKShlEDKPYRCPTCGMGYTLPQSLRRHQLS 620
Cdd:COG5048  366 LLNNEPP---QSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKI 440


                 .
gi 296080783 621 H 621
Cdd:COG5048  441 H 441
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 369-449 1.34e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080783 369 GHKPFLC--TECGKSYSSEESFKAHML-GHRGVRPFPCPQCDKaygtqrdlkeHQVVHSGARPFACDQCGKAFARRPSLR 445
Cdd:COG5189  346 DGKPYKCpvEGCNKKYKNQNGLKYHMLhGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....
gi 296080783 446 LHRK 449
Cdd:COG5189  416 YHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
502-525 1.73e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.73e-04
                          10        20
                  ....*....|....*....|....
gi 296080783  502 NLRGHLRLHTGERPYRCPHCADAF 525
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 73-168 1.85e-04

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 41.56  E-value: 1.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080783  73 PLQPGLLWGP----LEEESASKEKGEGVKPRqeenLSLGPWGDVCACEQSSGWTSLVQRGRLESEGNVAPVRISERLHLQ 148
Cdd:cd19201   27 PLPEGTRFGPypgkLVKEPLDPSYEWKVEAQ----GSKGGEGLLLLTEDSGTWLKLVRSADDEDEANLILYFKGGQIWCE 102

                         90       100
                 ....*....|....*....|
gi 296080783 149 VYQLVLPGSELLLWPQPSSE 168
Cdd:cd19201  103 VTKDIPPGEELILVLREPLL 122
zf-H2C2_2 pfam13465
Zinc-finger double domain;
586-609 6.62e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.62e-04
                          10        20
                  ....*....|....*....|....
gi 296080783  586 LRRHLKSHLEDKPYRCPTCGMGYT 609
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
359-384 7.16e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.16e-04
                          10        20
                  ....*....|....*....|....*.
gi 296080783  359 HLKKHAFVHTGHKPFLCTECGKSYSS 384
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 488-510 1.11e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.11e-03
                          10        20
                  ....*....|....*....|...
gi 296080783  488 FLCPHCGRAFRQRGNLRGHLRLH 510
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 567-617 2.02e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 2.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 296080783 567 GERPFPCP--QCGRAYTLATKLRRH-LKSH------------------LEDKPYRCPTCGMGYTLPQSLRRH 617
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHmLHGHqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 429-451 2.82e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.82e-03
                          10        20
                  ....*....|....*....|...
gi 296080783  429 FACDQCGKAFARRPSLRLHRKTH 451
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
387-410 4.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.03e-03
                          10        20
                  ....*....|....*....|....
gi 296080783  387 SFKAHMLGHRGVRPFPCPQCDKAY 410
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
PHA00733 PHA00733
hypothetical protein
 515-561 4.32e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.93  E-value: 4.32e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 296080783 515 PYRCPHCADAFPQLPELRRHlISHTGEAHLCPVCGKALRDPHTLRAH 561
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH-IRYTEHSKVCPVCGKEFRNTDSTLDH 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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