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Conserved domains on  [gi|295389583|ref|NP_001171303|]
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zinc finger protein 997 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 4.79e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.29  E-value: 4.79e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 295389583    4 VTFDDVHVNFTKEEWNLMDPSQMNLYKDVMLETYWNLTSIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-564 2.30e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 2.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 129 RPYECNQCGKAFSSHSNLRYHKRTHTGEKPYECNQ--CGKAFARPADLQYHKRTHTGEKPYECNQCGKafSCHSGLRYHK 206
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 207 RTHTGEKPYECNQC-----GKAFARPADLQYHKRTHTGEKPYE-CNQCGKAFSCHSGLRYHKRTHtgekpyecNQCGKAF 280
Cdd:COG5048  110 LSSSSSNSNDNNLLsshslPPSSRDPQLPDLLSISNLRNNPLPgNNSSSVNTPQSNSLHPPLPAN--------SLSKDPS 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 281 SCHSgLRYHKRTHTGEKPFECNQCGKAFSSHSGLRYHKRTHTGEKPYECNQCgkSFATSRHLQCHKRTHTgekpyecnqc 360
Cdd:COG5048  182 SNLS-LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSL---------- 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 361 gkafaTSSHLQCHKRTHtgekpYECNQCGKAFSCHSGLRHHKRTHTG-EKPYECNQCGKAFSRPAYLQHHKRT--HTGE- 436
Cdd:COG5048  249 -----SSSDSSSSASES-----PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEs 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 437 -KPYEC--NQCGKAFAKPSHLQCHKRTHTGEKPFEC--NQCGKAFS-----CYNSLRYHKRTHTGEKLYEC--NQCGKAF 504
Cdd:COG5048  319 lKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNF 398

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 295389583 505 ATSSHLQCHKRTHTGEKPYECN--QCGKAFATSSHLHCHKRTHTGEKPFECNQCGKAFARPS 564
Cdd:COG5048  399 KRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 99-154 9.62e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 9.62e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 295389583  99 GEKPYKCN--QCGKAFSSHSCLRYHKRN-------------------HTGERPYECNQCGKAFSSHSNLRYHkRTHT 154
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHghqnqklhenpspekmnifSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
565-590 2.96e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.96e-03
                          10        20
                  ....*....|....*....|....*.
gi 295389583  565 HLQIHKRTHTGEKPYECNQCGKAFAT 590
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 4.79e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.29  E-value: 4.79e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 295389583    4 VTFDDVHVNFTKEEWNLMDPSQMNLYKDVMLETYWNLTSIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-46 1.38e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.94  E-value: 1.38e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 295389583     4 VTFDDVHVNFTKEEWNLMDPSQMNLYKDVMLETYWNLTSIGYK 46
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 1.14e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.74  E-value: 1.14e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 295389583   4 VTFDDVHVNFTKEEWNLMDPSQMNLYKDVMLETYWNLTSI 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-564 2.30e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 2.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 129 RPYECNQCGKAFSSHSNLRYHKRTHTGEKPYECNQ--CGKAFARPADLQYHKRTHTGEKPYECNQCGKafSCHSGLRYHK 206
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 207 RTHTGEKPYECNQC-----GKAFARPADLQYHKRTHTGEKPYE-CNQCGKAFSCHSGLRYHKRTHtgekpyecNQCGKAF 280
Cdd:COG5048  110 LSSSSSNSNDNNLLsshslPPSSRDPQLPDLLSISNLRNNPLPgNNSSSVNTPQSNSLHPPLPAN--------SLSKDPS 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 281 SCHSgLRYHKRTHTGEKPFECNQCGKAFSSHSGLRYHKRTHTGEKPYECNQCgkSFATSRHLQCHKRTHTgekpyecnqc 360
Cdd:COG5048  182 SNLS-LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSL---------- 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 361 gkafaTSSHLQCHKRTHtgekpYECNQCGKAFSCHSGLRHHKRTHTG-EKPYECNQCGKAFSRPAYLQHHKRT--HTGE- 436
Cdd:COG5048  249 -----SSSDSSSSASES-----PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEs 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 437 -KPYEC--NQCGKAFAKPSHLQCHKRTHTGEKPFEC--NQCGKAFS-----CYNSLRYHKRTHTGEKLYEC--NQCGKAF 504
Cdd:COG5048  319 lKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNF 398

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 295389583 505 ATSSHLQCHKRTHTGEKPYECN--QCGKAFATSSHLHCHKRTHTGEKPFECNQCGKAFARPS 564
Cdd:COG5048  399 KRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 99-154 9.62e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 9.62e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 295389583  99 GEKPYKCN--QCGKAFSSHSCLRYHKRN-------------------HTGERPYECNQCGKAFSSHSNLRYHkRTHT 154
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHghqnqklhenpspekmnifSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
145-170 9.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.95e-04
                          10        20
                  ....*....|....*....|....*.
gi 295389583  145 NLRYHKRTHTGEKPYECNQCGKAFAR 170
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
565-590 2.96e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.96e-03
                          10        20
                  ....*....|....*....|....*.
gi 295389583  565 HLQIHKRTHTGEKPYECNQCGKAFAT 590
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 4.79e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.29  E-value: 4.79e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 295389583    4 VTFDDVHVNFTKEEWNLMDPSQMNLYKDVMLETYWNLTSIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-46 1.38e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.94  E-value: 1.38e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 295389583     4 VTFDDVHVNFTKEEWNLMDPSQMNLYKDVMLETYWNLTSIGYK 46
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 1.14e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.74  E-value: 1.14e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 295389583   4 VTFDDVHVNFTKEEWNLMDPSQMNLYKDVMLETYWNLTSI 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-564 2.30e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 2.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 129 RPYECNQCGKAFSSHSNLRYHKRTHTGEKPYECNQ--CGKAFARPADLQYHKRTHTGEKPYECNQCGKafSCHSGLRYHK 206
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 207 RTHTGEKPYECNQC-----GKAFARPADLQYHKRTHTGEKPYE-CNQCGKAFSCHSGLRYHKRTHtgekpyecNQCGKAF 280
Cdd:COG5048  110 LSSSSSNSNDNNLLsshslPPSSRDPQLPDLLSISNLRNNPLPgNNSSSVNTPQSNSLHPPLPAN--------SLSKDPS 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 281 SCHSgLRYHKRTHTGEKPFECNQCGKAFSSHSGLRYHKRTHTGEKPYECNQCgkSFATSRHLQCHKRTHTgekpyecnqc 360
Cdd:COG5048  182 SNLS-LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSL---------- 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 361 gkafaTSSHLQCHKRTHtgekpYECNQCGKAFSCHSGLRHHKRTHTG-EKPYECNQCGKAFSRPAYLQHHKRT--HTGE- 436
Cdd:COG5048  249 -----SSSDSSSSASES-----PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEs 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 437 -KPYEC--NQCGKAFAKPSHLQCHKRTHTGEKPFEC--NQCGKAFS-----CYNSLRYHKRTHTGEKLYEC--NQCGKAF 504
Cdd:COG5048  319 lKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNF 398

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 295389583 505 ATSSHLQCHKRTHTGEKPYECN--QCGKAFATSSHLHCHKRTHTGEKPFECNQCGKAFARPS 564
Cdd:COG5048  399 KRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
72-486 2.43e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 2.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583  72 KKLYECNQCGKVFARPAHIQCHKRTHTGEKPYKCNQ--CGKAFSSHSCLRYHKRNHTGERPYECNQCGKafSSHSNLRYH 149
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 150 KRTHTGEKPYECNQC-----GKAFARPADLQYHKRTHTGEKPYE-CNQCGKAFSCHSGLRYHKRTHTGEKPYEcnqcgka 223
Cdd:COG5048  109 SLSSSSSNSNDNNLLsshslPPSSRDPQLPDLLSISNLRNNPLPgNNSSSVNTPQSNSLHPPLPANSLSKDPS------- 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 224 faRPADLQYHKRTHTGEKPYECNQCGKAFSCHSGLRYHKRTHTGEKPYECNQCGKAFSCHSGLRYHKRTHTGEKPFECNQ 303
Cdd:COG5048  182 --SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 304 CG------KAFSSHSGLRYHKRTHTG-EKPYECNQCGKSFATSRHLQCHKRT--HTGE--KPYEC--NQCGKAFATSSHL 370
Cdd:COG5048  260 SPrsslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDAL 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 371 QCHKRTHTGEKPYEC--NQCGKAFS-----CHSGLRHHKRTHTGEKPYEC--NQCGKAFSRPAYLQHHKRTHTGEKPYEC 441
Cdd:COG5048  340 KRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNC 419

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 295389583 442 N--QCGKAFAKPSHLQCHKRTHTGEKPFECNQCGKAFSCYNSLRYHK 486
Cdd:COG5048  420 KnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
68-262 6.32e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 6.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583  68 SHRWKKLYECNQCGKVFARPAHIQCHKRTHTG-EKPYKCNQCGKAFSSHSCLRYHKR--NHTGE--RPYEC--NQCGKAF 140
Cdd:COG5048  254 SSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLF 333

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 141 SSHSNLRYHKRTHTGEKPYEC--NQCGKAF-----ARPADLQYHKRTHTGEKPYEC--NQCGKAFSCHSGLRYHKRTHTG 211
Cdd:COG5048  334 SRNDALKRHILLHTSISPAKEklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLS 413

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 295389583 212 EKPYECN--QCGKAFARPADLQYHKRTHTGEKPYECNQCGKAFSCHSGLRYHK 262
Cdd:COG5048  414 FRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
241-592 1.57e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 241 KPYECNQCGKAFSCHSGLRYHKRTHTGEKPYECNQCGKAFSCHSG--LRYHKRTHTGEKPFECNQCGKafSSHSGLRYHK 318
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 319 RTHTGEKPYECNQC-----------------------------------------------------GKSFATSRHLQCH 345
Cdd:COG5048  110 LSSSSSNSNDNNLLsshslppssrdpqlpdllsisnlrnnplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 346 KRTHTGEKPYECNQCGKAFATSSHLQCHKRTHTGEKPYECNQCGKAFSCH------SGLRHHKRTHTGEKPYECNQCGKA 419
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 420 FSRPAYLQHHKRTHTG-EKPYECNQCGKAFAKPSHLQCHKRT--HTGE--KPFEC--NQCGKAFSCYNSLRYHKRTHTGE 492
Cdd:COG5048  270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 493 KLYEC--NQCGKAFATSSH-----LQCHKRTHTGEKPYEC--NQCGKAFATSSHLHCHKRTHTGEKP--FECNQCGKAFA 561
Cdd:COG5048  350 SPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFN 429

                        410       420       430
                 ....*....|....*....|....*....|.
gi 295389583 562 RPSHLQIHKRTHTGEKPYECNQCGKAFATSS 592
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
325-602 7.69e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 7.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 325 KPYECNQCGKSFATSRHLQCHKRTHTGEKPYECNQ--CGKAFATSSHLQCHKRTHTGEKPYECNQCGKafSCHSGLRHHK 402
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 403 RTHTGEKPYECNQC---GKAFSRPAYLQHHKRTHTGEKPYECNQCGKAFA----------------------KPSHLQCH 457
Cdd:COG5048  110 LSSSSSNSNDNNLLsshSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpsSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 458 KRTHTGEKPFECNQCGKAFSCYNSLRYHKRTHTGEKLYECNQCGKAFatSSHLQCHKRTHTGEK--------PYECNQCG 529
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLS--PKSLLSQSPSSLSSSdssssaseSPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 530 KAFATSSHLHCHKRTHTG-EKPFECNQCGKAFARPSHLQIHKRT--HTGE--KPYEC--NQCGKAFATSSHLQCHKRTHT 602
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 171-266 1.94e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.41  E-value: 1.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 171 PADLQYHKrthtGEKPYECN--QCGKAFSCHSGLRYHKRthtgekpyECNQCGKAFARPADLQyHKRTHTGEKPYECNQC 248
Cdd:COG5189  338 PSRMLKVK----DGKPYKCPveGCNKKYKNQNGLKYHML--------HGHQNQKLHENPSPEK-MNIFSAKDKPYRCEVC 404

                         90
                 ....*....|....*...
gi 295389583 249 GKAFSCHSGLRYHkRTHT 266
Cdd:COG5189  405 DKRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 127-210 3.96e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 3.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 127 GERPYECN--QCGKAFSSHSNLRYHKRthtgekpyECNQCGKAFARPADLQyHKRTHTGEKPYECNQCGKAFSCHSGLRY 204
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML--------HGHQNQKLHENPSPEK-MNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 295389583 205 HkRTHT 210
Cdd:COG5189  417 H-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 227-294 1.36e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 227 PADLQYHKrthtGEKPYECN--QCGKAFSCHSGLRYHK-------RTH------------TGEKPYECNQCGKAFSCHSG 285
Cdd:COG5189  338 PSRMLKVK----DGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNG 413


                 ....*....
gi 295389583 286 LRYHkRTHT 294
Cdd:COG5189  414 LKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 99-154 9.62e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 9.62e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 295389583  99 GEKPYKCN--QCGKAFSSHSCLRYHKRN-------------------HTGERPYECNQCGKAFSSHSNLRYHkRTHT 154
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHghqnqklhenpspekmnifSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
145-170 9.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.95e-04
                          10        20
                  ....*....|....*....|....*.
gi 295389583  145 NLRYHKRTHTGEKPYECNQCGKAFAR 170
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-338 2.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.36e-03
                          10        20
                  ....*....|....*....|....*
gi 295389583  314 LRYHKRTHTGEKPYECNQCGKSFAT 338
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-198 2.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.46e-03
                          10        20
                  ....*....|....*....|....*.
gi 295389583  173 DLQYHKRTHTGEKPYECNQCGKAFSC 198
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
229-254 2.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.46e-03
                          10        20
                  ....*....|....*....|....*.
gi 295389583  229 DLQYHKRTHTGEKPYECNQCGKAFSC 254
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
202-226 2.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.53e-03
                          10        20
                  ....*....|....*....|....*
gi 295389583  202 LRYHKRTHTGEKPYECNQCGKAFAR 226
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
258-282 2.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.68e-03
                          10        20
                  ....*....|....*....|....*
gi 295389583  258 LRYHKRTHTGEKPYECNQCGKAFSC 282
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
565-590 2.96e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.96e-03
                          10        20
                  ....*....|....*....|....*.
gi 295389583  565 HLQIHKRTHTGEKPYECNQCGKAFAT 590
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-310 3.33e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.33e-03
                          10        20
                  ....*....|....*....|....*
gi 295389583  286 LRYHKRTHTGEKPFECNQCGKAFSS 310
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 295-378 6.32e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 6.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389583 295 GEKPFECN--QCGKAFSSHSGLRYHKRT-HTGEKPYECNQCGKsfatsrhlqcHKRTHTGEKPYECNQCGKAFATSSHLQ 371
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....*..
gi 295389583 372 CHkRTHT 378
Cdd:COG5189  416 YH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
118-142 8.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.39e-03
                          10        20
                  ....*....|....*....|....*
gi 295389583  118 LRYHKRNHTGERPYECNQCGKAFSS 142
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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