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Conserved domains on  [gi|293629103|ref|NP_001170784|]
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origin recognition complex subunit 4 isoform 2 [Mus musculus]

Protein Classification

ATP-binding protein( domain architecture ID 10588955)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain similar to Mus musculus origin recognition complex subunit 4 isoform 2

CATH:  3.40.50.300
Gene Ontology:  GO:0005524|GO:0016887
PubMed:  15037234|18208389|17897320|18466635|16072036|11916378|15037233
SCOP:  2000039

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 34-82 3.12e-06

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


:

Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 44.03  E-value: 3.12e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 293629103   34 NLFGVQVQYKHLIELLKRTAIyGESNSVLIVGPRGSGKTTLLNHALKEL 82
Cdd:pfam13191   1 RLVGREEELEQLLDALDRVRS-GRPPSVLLTGEAGTGKTTLLRELLRAL 48
PulE super family cl34488
Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell ...
 61-114 6.17e-06

Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


The actual alignment was detected with superfamily member COG2804:

Pssm-ID: 442055 [Multi-domain]  Cd Length: 561  Bit Score: 44.03  E-value: 6.17e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 293629103  61 VLIVGPRGSGKTTLLNHALKELMEIEVseNVIQV------HLNGLLQT--NEKI------ALKEITRQ 114
Cdd:COG2804  316 ILVTGPTGSGKTTTLYAALNELNTPER--NIITVedpveyQLPGINQVqvNPKIgltfasALRSILRQ 381
 
Name Accession Description Interval E-value
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 34-82 3.12e-06

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 44.03  E-value: 3.12e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 293629103   34 NLFGVQVQYKHLIELLKRTAIyGESNSVLIVGPRGSGKTTLLNHALKEL 82
Cdd:pfam13191   1 RLVGREEELEQLLDALDRVRS-GRPPSVLLTGEAGTGKTTLLRELLRAL 48
PulE COG2804
Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell ...
 61-114 6.17e-06

Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442055 [Multi-domain]  Cd Length: 561  Bit Score: 44.03  E-value: 6.17e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 293629103  61 VLIVGPRGSGKTTLLNHALKELMEIEVseNVIQV------HLNGLLQT--NEKI------ALKEITRQ 114
Cdd:COG2804  316 ILVTGPTGSGKTTTLYAALNELNTPER--NIITVedpveyQLPGINQVqvNPKIgltfasALRSILRQ 381
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 44-101 1.06e-05

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 42.52  E-value: 1.06e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 293629103  44 HLIELLKRTAIYGESNSVLIVGPRGSGKTTLLNHALKELmeIEVSENVIQVHLNGLLQ 101
Cdd:cd00009    5 EAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANEL--FRPGAPFLYLNASDLLE 60
PulE-GspE-like cd01129
PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II ...
 61-114 3.79e-05

PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II secretory pathway, the main terminal branch of the general secretory pathway (GSP). PulE is a cytoplasmic protein of the GSP, which contains an ATP binding site and a tetracysteine motif. This subgroup also includes PilB, a type IV pilus assembly ATPase, DotB, an ATPase of the type IVb secretion system, also known as the dot/icm system, Escherichia coli IncI plasmid-encoded conjugative transfer ATPase TraJ, and HofB.


Pssm-ID: 410873 [Multi-domain]  Cd Length: 159  Bit Score: 40.93  E-value: 3.79e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 293629103  61 VLIVGPRGSGKTTLLNHALKELMEIEVS----ENVIQVHLNGLLQT--NEKI------ALKEITRQ 114
Cdd:cd01129   14 ILVTGPTGSGKTTTLYAMLRELNGPERNiitiEDPVEYQIPGINQSqvNEKIgltfadALRAILRQ 79
COG1373 COG1373
Predicted ATPase, AAA+ superfamily [General function prediction only];
42-85 4.57e-05

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440984 [Multi-domain]  Cd Length: 405  Bit Score: 41.47  E-value: 4.57e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 293629103  42 YKHLIELLKRTAIygesnsVLIVGPRGSGKTTLLNHALKELMEI 85
Cdd:COG1373   10 LDKLLKLLDNRKA------VVITGPRQVGKTTLLKQLAKELENI 47
cdc6 PRK00411
ORC1-type DNA replication protein;
46-130 4.72e-05

ORC1-type DNA replication protein;


Pssm-ID: 234751 [Multi-domain]  Cd Length: 394  Bit Score: 41.76  E-value: 4.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 293629103  46 IELLK---RTAIYGESNS-VLIVGPRGSGKTTLLNHALKELMEIevSENVIQVHLNGLLQTNEKIALKEITRQLNLDNVV 121
Cdd:PRK00411  39 IEELAfalRPALRGSRPLnVLIYGPPGTGKTTTVKKVFEELEEI--AVKVVYVYINCQIDRTRYAIFSEIARQLFGHPPP 116

                         90
                 ....*....|....
gi 293629103 122 E-----DKVFGMLV 130
Cdd:PRK00411 117 SsglsfDELFDKIA 130
T2SSE pfam00437
Type II/IV secretion system protein; This family contains components of both the Type II ...
 60-114 1.10e-04

Type II/IV secretion system protein; This family contains components of both the Type II protein secretion system (T2SS), including Type 4 pilus (T4P), and Type IV protein secretion system (T4SS) from Gram-negative bacteria. VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection. The cytoplasmic T2S E ATPase is a Zn-containing protein thought to provide the mechanical force for the secretion process. T2S-E contains Walker A and B motifs, that are essential for secretion and ATPase activity. ATPase PulE and XcpR from Klebsiella oxytoca and Pseudomonas aeruginosa respectively are required for protein secretion via the T2SS. ATPase PilB is required for T4P extension.


Pssm-ID: 425681 [Multi-domain]  Cd Length: 269  Bit Score: 40.35  E-value: 1.10e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 293629103   60 SVLIVGPRGSGKTTLLNHALKELMEIEVS----ENVIQVHLNGLLQT--NEKI------ALKEITRQ 114
Cdd:pfam00437 132 NILVTGPTGSGKTTTLYAALGELNTRDENivtvEDPVEIQLEGINQVqlNARAgvtfadLLRAILRQ 198
VI_IcmF TIGR03348
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to ...
 38-78 7.15e-04

type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to be associated with type VI secretion systems. [Cellular processes, Pathogenesis]


Pssm-ID: 274531 [Multi-domain]  Cd Length: 1169  Bit Score: 38.47  E-value: 7.15e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 293629103    38 VQVQYKHLIELLKRTAIYGEsNSV------LIVGPRGSGKTTLLNHA 78
Cdd:TIGR03348   86 LRARFNEALALLKRSRLGGR-RYLydlpwyLVIGPPGSGKTTLLQNS 131
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 59-136 1.57e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 36.58  E-value: 1.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 293629103    59 NSVLIVGPRGSGKTTLLNHALKELME---------IEVSENVIQVHLNGLLQTNEKIALKEITRQLNLDNVVEDKVFGML 129
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGPpgggviyidGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDVL 82


                   ....*..
gi 293629103   130 VCLEVSK 136
Cdd:smart00382  83 ILDEITS 89
PRK13894 PRK13894
conjugal transfer ATPase TrbB; Provisional
 51-101 3.00e-03

conjugal transfer ATPase TrbB; Provisional


Pssm-ID: 184377  Cd Length: 319  Bit Score: 36.26  E-value: 3.00e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 293629103  51 RTAIYGESNsVLIVGPRGSGKTTLLNHALKELMEIEVSENVIQVHLNGLLQ 101
Cdd:PRK13894 142 IAAVRAHRN-ILVIGGTGSGKTTLVNAIINEMVIQDPTERVFIIEDTGEIQ 191
 
Name Accession Description Interval E-value
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 34-82 3.12e-06

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 44.03  E-value: 3.12e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 293629103   34 NLFGVQVQYKHLIELLKRTAIyGESNSVLIVGPRGSGKTTLLNHALKEL 82
Cdd:pfam13191   1 RLVGREEELEQLLDALDRVRS-GRPPSVLLTGEAGTGKTTLLRELLRAL 48
PulE COG2804
Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell ...
 61-114 6.17e-06

Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442055 [Multi-domain]  Cd Length: 561  Bit Score: 44.03  E-value: 6.17e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 293629103  61 VLIVGPRGSGKTTLLNHALKELMEIEVseNVIQV------HLNGLLQT--NEKI------ALKEITRQ 114
Cdd:COG2804  316 ILVTGPTGSGKTTTLYAALNELNTPER--NIITVedpveyQLPGINQVqvNPKIgltfasALRSILRQ 381
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 44-101 1.06e-05

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 42.52  E-value: 1.06e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 293629103  44 HLIELLKRTAIYGESNSVLIVGPRGSGKTTLLNHALKELmeIEVSENVIQVHLNGLLQ 101
Cdd:cd00009    5 EAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANEL--FRPGAPFLYLNASDLLE 60
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
41-130 2.73e-05

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 42.14  E-value: 2.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 293629103  41 QYKHLIELLkRTAIYGES-NSVLIVGPRGSGKTTLLNHALKELMEI--EVSENVIQVHLNGLLQTNEKIALKEITRQLNL 117
Cdd:COG1474   34 EIEELASAL-RPALRGERpSNVLIYGPTGTGKTAVAKYVLEELEEEaeERGVDVRVVYVNCRQASTRYRVLSRILEELGS 112

                         90
                 ....*....|....*....
gi 293629103 118 DNVVE------DKVFGMLV 130
Cdd:COG1474  113 GEDIPstglstDELFDRLY 131
PulE-GspE-like cd01129
PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II ...
 61-114 3.79e-05

PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II secretory pathway, the main terminal branch of the general secretory pathway (GSP). PulE is a cytoplasmic protein of the GSP, which contains an ATP binding site and a tetracysteine motif. This subgroup also includes PilB, a type IV pilus assembly ATPase, DotB, an ATPase of the type IVb secretion system, also known as the dot/icm system, Escherichia coli IncI plasmid-encoded conjugative transfer ATPase TraJ, and HofB.


Pssm-ID: 410873 [Multi-domain]  Cd Length: 159  Bit Score: 40.93  E-value: 3.79e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 293629103  61 VLIVGPRGSGKTTLLNHALKELMEIEVS----ENVIQVHLNGLLQT--NEKI------ALKEITRQ 114
Cdd:cd01129   14 ILVTGPTGSGKTTTLYAMLRELNGPERNiitiEDPVEYQIPGINQSqvNEKIgltfadALRAILRQ 79
COG1373 COG1373
Predicted ATPase, AAA+ superfamily [General function prediction only];
42-85 4.57e-05

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440984 [Multi-domain]  Cd Length: 405  Bit Score: 41.47  E-value: 4.57e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 293629103  42 YKHLIELLKRTAIygesnsVLIVGPRGSGKTTLLNHALKELMEI 85
Cdd:COG1373   10 LDKLLKLLDNRKA------VVITGPRQVGKTTLLKQLAKELENI 47
cdc6 PRK00411
ORC1-type DNA replication protein;
46-130 4.72e-05

ORC1-type DNA replication protein;


Pssm-ID: 234751 [Multi-domain]  Cd Length: 394  Bit Score: 41.76  E-value: 4.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 293629103  46 IELLK---RTAIYGESNS-VLIVGPRGSGKTTLLNHALKELMEIevSENVIQVHLNGLLQTNEKIALKEITRQLNLDNVV 121
Cdd:PRK00411  39 IEELAfalRPALRGSRPLnVLIYGPPGTGKTTTVKKVFEELEEI--AVKVVYVYINCQIDRTRYAIFSEIARQLFGHPPP 116

                         90
                 ....*....|....
gi 293629103 122 E-----DKVFGMLV 130
Cdd:PRK00411 117 SsglsfDELFDKIA 130
AAA_14 pfam13173
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 61-86 9.07e-05

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 463799 [Multi-domain]  Cd Length: 128  Bit Score: 39.49  E-value: 9.07e-05
                          10        20
                  ....*....|....*....|....*.
gi 293629103   61 VLIVGPRGSGKTTLLNHALKELMEIE 86
Cdd:pfam13173   5 LVITGPRQVGKTTLLLQLIKELLPPE 30
T2SSE pfam00437
Type II/IV secretion system protein; This family contains components of both the Type II ...
 60-114 1.10e-04

Type II/IV secretion system protein; This family contains components of both the Type II protein secretion system (T2SS), including Type 4 pilus (T4P), and Type IV protein secretion system (T4SS) from Gram-negative bacteria. VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection. The cytoplasmic T2S E ATPase is a Zn-containing protein thought to provide the mechanical force for the secretion process. T2S-E contains Walker A and B motifs, that are essential for secretion and ATPase activity. ATPase PulE and XcpR from Klebsiella oxytoca and Pseudomonas aeruginosa respectively are required for protein secretion via the T2SS. ATPase PilB is required for T4P extension.


Pssm-ID: 425681 [Multi-domain]  Cd Length: 269  Bit Score: 40.35  E-value: 1.10e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 293629103   60 SVLIVGPRGSGKTTLLNHALKELMEIEVS----ENVIQVHLNGLLQT--NEKI------ALKEITRQ 114
Cdd:pfam00437 132 NILVTGPTGSGKTTTLYAALGELNTRDENivtvEDPVEIQLEGINQVqlNARAgvtfadLLRAILRQ 198
COG3899 COG3899
Predicted ATPase [General function prediction only];
10-82 2.55e-04

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 39.84  E-value: 2.55e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 293629103   10 AHAECLSQVQRILRERFCHHSPHSNLFGVQVQYKHLIELLKRtAIYGESNSVLIVGPRGSGKTTLLNHALKEL 82
Cdd:COG3899   264 LLLLGLLAAAAAGRRLLARRLIPQPLVGREAELAALLAALER-ARAGRGELVLVSGEAGIGKSRLVRELARRA 335
LolD COG1136
ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis];
61-76 3.03e-04

ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440751 [Multi-domain]  Cd Length: 227  Bit Score: 38.87  E-value: 3.03e-04
                         10
                 ....*....|....*.
gi 293629103  61 VLIVGPRGSGKTTLLN 76
Cdd:COG1136   37 VAIVGPSGSGKSTLLN 52
DAP3 pfam10236
Mitochondrial ribosomal death-associated protein 3; This is a family of conserved proteins ...
 45-79 4.11e-04

Mitochondrial ribosomal death-associated protein 3; This is a family of conserved proteins which were originally described as death-associated-protein-3 (DAP-3). The proteins carry a P-loop DNA-binding motif, and induce apoptosis. DAP3 has been shown to be a pro-apoptotic factor in the mitochondrial matrix and to be crucial for mitochondrial biogenesis and so has also been designated as MRP-S29 (mitochondrial ribosomal protein subunit 29).


Pssm-ID: 431160  Cd Length: 310  Bit Score: 38.82  E-value: 4.11e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 293629103   45 LIELLKRTAIYGESNSVLIVGPRGSGKTTLLNHAL 79
Cdd:pfam10236  10 LIKKLKAADKSKKVVRFVLTGEPGSGKSVLLLQAM 44
ABC_MJ0796_LolCDE_FtsE cd03255
ATP-binding cassette domain of the transporters involved in export of lipoprotein and ...
 61-76 4.98e-04

ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and Cell division ATP-binding protein FtsE; This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.


Pssm-ID: 213222 [Multi-domain]  Cd Length: 218  Bit Score: 38.24  E-value: 4.98e-04
                         10
                 ....*....|....*.
gi 293629103  61 VLIVGPRGSGKTTLLN 76
Cdd:cd03255   33 VAIVGPSGSGKSTLLN 48
VirB11 COG0630
Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell ...
 60-76 5.99e-04

Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell motility, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440395 [Multi-domain]  Cd Length: 462  Bit Score: 38.52  E-value: 5.99e-04
                         10
                 ....*....|....*..
gi 293629103  60 SVLIVGPRGSGKTTLLN 76
Cdd:COG0630  292 SVLVAGGTASGKTTLLN 308
VI_IcmF TIGR03348
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to ...
 38-78 7.15e-04

type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to be associated with type VI secretion systems. [Cellular processes, Pathogenesis]


Pssm-ID: 274531 [Multi-domain]  Cd Length: 1169  Bit Score: 38.47  E-value: 7.15e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 293629103    38 VQVQYKHLIELLKRTAIYGEsNSV------LIVGPRGSGKTTLLNHA 78
Cdd:TIGR03348   86 LRARFNEALALLKRSRLGGR-RYLydlpwyLVIGPPGSGKTTLLQNS 131
cobW pfam02492
CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase ...
 61-84 7.20e-04

CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase expression / formation protein, and UreG a urease accessory protein. Both these proteins contain a P-loop nucleotide binding motif. HypB has GTPase activity and is a guanine nucleotide binding protein. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression. UreG is required for functional incorporation of the urease nickel metallocenter. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins. This family of domains also contains P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product, which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans.


Pssm-ID: 396860  Cd Length: 179  Bit Score: 37.62  E-value: 7.20e-04
                          10        20
                  ....*....|....*....|....
gi 293629103   61 VLIVGPRGSGKTTLLNHALKELME 84
Cdd:pfam02492   3 TVITGFLGSGKTTLLNHLLKQNRA 26
COG1672 COG1672
Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];
46-81 7.50e-04

Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];


Pssm-ID: 441278 [Multi-domain]  Cd Length: 324  Bit Score: 37.97  E-value: 7.50e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 293629103  46 IELLKRTAIYGESNSVLIVGPRGSGKTTLLNHALKE 81
Cdd:COG1672    9 LEELEKLYESDGGELVVVYGRRRVGKTSLIKEFLKE 44
ABCC_MRP_domain1 cd03250
ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This ...
 61-95 1.00e-03

ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This subfamily is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate.


Pssm-ID: 213217 [Multi-domain]  Cd Length: 204  Bit Score: 37.45  E-value: 1.00e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 293629103  61 VLIVGPRGSGKTTLLNhALkeLMEIEVSENVIQVH 95
Cdd:cd03250   34 VAIVGPVGSGKSSLLS-AL--LGELEKLSGSVSVP 65
CpaF COG4962
Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and ...
 60-92 1.31e-03

Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 443988 [Multi-domain]  Cd Length: 386  Bit Score: 37.45  E-value: 1.31e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 293629103  60 SVLIVGPRGSGKTTLLNhALkeLMEIEVSENVI 92
Cdd:COG4962  184 NILVSGGTGSGKTTLLN-AL--SGFIPPDERIV 213
YbbA COG4181
Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase ...
 56-75 1.42e-03

Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443338 [Multi-domain]  Cd Length: 233  Bit Score: 37.03  E-value: 1.42e-03
                         10        20
                 ....*....|....*....|
gi 293629103  56 GESnsVLIVGPRGSGKTTLL 75
Cdd:COG4181   38 GES--VAIVGASGSGKSTLL 55
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 59-136 1.57e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 36.58  E-value: 1.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 293629103    59 NSVLIVGPRGSGKTTLLNHALKELME---------IEVSENVIQVHLNGLLQTNEKIALKEITRQLNLDNVVEDKVFGML 129
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGPpgggviyidGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPDVL 82


                   ....*..
gi 293629103   130 VCLEVSK 136
Cdd:smart00382  83 ILDEITS 89
IcmF COG3523
Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and ...
 20-77 2.11e-03

Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442745 [Multi-domain]  Cd Length: 1192  Bit Score: 36.86  E-value: 2.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 293629103   20 RILRERFchhsphsnlfgvqvqyKHLIELLKRTAIYGESNSV--------LIVGPRGSGKTTLLNH 77
Cdd:COG3523    96 EALRERF----------------QEALATLKKSRLGQGGGRRalyelpwyLIIGPPGAGKTTALVN 145
COG4928 COG4928
Predicted P-loop ATPase, KAP-like [General function prediction only];
35-115 2.47e-03

Predicted P-loop ATPase, KAP-like [General function prediction only];


Pssm-ID: 443956  Cd Length: 386  Bit Score: 36.81  E-value: 2.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 293629103  35 LFGVQVQYKHLIELLKRtAIYGESNSVLIVGPRGSGKTTLLNHALKELmeiEVSENVIQVHLNGLLQTNE---KIAL-KE 110
Cdd:COG4928    7 LLGRKKYAESLANLIKS-SDADEPLVIGLDGEWGSGKTSFLNLIEKEL---ESNEKVIVVYFNAWLYDGEedlLAALlSE 82


                 ....*
gi 293629103 111 ITRQL 115
Cdd:COG4928   83 IAAEL 87
Gmk COG0194
Guanylate kinase [Nucleotide transport and metabolism];
62-88 2.96e-03

Guanylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 439964  Cd Length: 190  Bit Score: 35.81  E-value: 2.96e-03
                         10        20
                 ....*....|....*....|....*....
gi 293629103  62 LIV--GPRGSGKTTLLNHALKELMEIEVS 88
Cdd:COG0194    4 LIVlsGPSGAGKTTLVKALLERDPDLRFS 32
PRK13894 PRK13894
conjugal transfer ATPase TrbB; Provisional
 51-101 3.00e-03

conjugal transfer ATPase TrbB; Provisional


Pssm-ID: 184377  Cd Length: 319  Bit Score: 36.26  E-value: 3.00e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 293629103  51 RTAIYGESNsVLIVGPRGSGKTTLLNHALKELMEIEVSENVIQVHLNGLLQ 101
Cdd:PRK13894 142 IAAVRAHRN-ILVIGGTGSGKTTLVNAIINEMVIQDPTERVFIIEDTGEIQ 191
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
61-117 3.08e-03

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 35.73  E-value: 3.08e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 293629103  61 VLIVGPRGSGKTTLLNhalkELMEIEVSENVIQVhLNGLLQTNEKIALKEITRQLNL 117
Cdd:COG1100    6 IVVVGTGGVGKTSLVN----RLVGDIFSLEKYLS-TNGVTIDKKELKLDGLDVDLVI 57
MobB COG1763
Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; ...
 63-82 3.12e-03

Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; Molybdopterin-guanine dinucleotide biosynthesis protein is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 441369 [Multi-domain]  Cd Length: 162  Bit Score: 35.54  E-value: 3.12e-03
                         10        20
                 ....*....|....*....|
gi 293629103  63 IVGPRGSGKTTLLNHALKEL 82
Cdd:COG1763    6 IVGYSGSGKTTLLEKLIPEL 25
YddA COG4178
ABC-type uncharacterized transport system, permease and ATPase components [General function ...
 56-75 4.41e-03

ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only];


Pssm-ID: 443337 [Multi-domain]  Cd Length: 571  Bit Score: 35.94  E-value: 4.41e-03
                         10        20
                 ....*....|....*....|
gi 293629103  56 GESnsVLIVGPRGSGKTTLL 75
Cdd:COG4178  389 GER--LLITGPSGSGKSTLL 406
AAA_7 pfam12775
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ...
 40-82 5.07e-03

P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).


Pssm-ID: 463698 [Multi-domain]  Cd Length: 179  Bit Score: 35.06  E-value: 5.07e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 293629103   40 VQYKHLIELLKRtaiygESNSVLIVGPRGSGKTTLLNHALKEL 82
Cdd:pfam12775  18 VRYTYLLDLLLK-----NGKPVLLVGPTGTGKTVIIQNLLRKL 55
ABC_cobalt_CbiO_domain1 cd03225
First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ...
 61-77 7.02e-03

First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.


Pssm-ID: 213192 [Multi-domain]  Cd Length: 211  Bit Score: 35.14  E-value: 7.02e-03
                         10
                 ....*....|....*..
gi 293629103  61 VLIVGPRGSGKTTLLNH 77
Cdd:cd03225   30 VLIVGPNGSGKSTLLRL 46
CobW-like cd03112
cobalamin synthesis protein CobW; The function of this protein family is unknown. The amino ...
 68-81 8.09e-03

cobalamin synthesis protein CobW; The function of this protein family is unknown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage caused by mitomycin. YijA gene is a homologue of the CobW gene which encodes the cobalamin synthesis protein/P47K.


Pssm-ID: 349766  Cd Length: 198  Bit Score: 34.80  E-value: 8.09e-03
                         10
                 ....*....|....
gi 293629103  68 GSGKTTLLNHALKE 81
Cdd:cd03112   10 GAGKTTLLNHILSE 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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