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Conserved domains on  [gi|288557353|ref|NP_001165697|]
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zinc finger protein 540 isoform b [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 8.30e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 96.77  E-value: 8.30e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 288557353    5 LVTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSLG 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-614 4.44e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 4.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 209 KPYECQECGKTFTLYPQLNRHQKIHTGKKPYMC--KKCDKGFFSRLELTQHKRIHTGKKSYEC-KECGKVFQLIFYFKEH 285
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 286 ERIHTGKKPYECKECGKAFSvcgqlTRHQKIHTGVKPYEckecgktFRLSFYLTEHRRTHAGKK------PYECKECGKS 359
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPS-----SRDPQLPDLLSISN-------LRNNPLPGNNSSSVNTPQsnslhpPLPANSLSKD 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 360 FNVRGQLNRHKTIHTGIKPFACKVCEKAFSYSGDLRVHSRIHTGEKPYECKECGKAFMLRSVLTEHQRLHTGVKPYECKE 439
Cdd:COG5048  180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 440 CGKTFRVRSQISLHKKIHTDV-------KPYKCVRCGKTFRFGFYLTEHQR--IHTGE--KPYKCKE--CGKAFIRRGNL 506
Cdd:COG5048  260 SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 507 KEHLKIHSGLKPYDCKEC-------GKSFSRRGQFTEHQKIHTGVKPYKC--KECGKAFSRSVDLRIHQRIHTGEKPYEC 577
Cdd:COG5048  340 KRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNC 419

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 288557353 578 K--QCGKAFRLNSHLTEHQRIHTGEKPYECKVCRKAFRQ 614
Cdd:COG5048  420 KnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 8.30e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 96.77  E-value: 8.30e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 288557353    5 LVTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSLG 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
6-47 1.61e-23

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 93.81  E-value: 1.61e-23
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 288557353     6 VTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSLGL 47
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 1.74e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.83  E-value: 1.74e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 288557353   6 VTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSL 45
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-614 4.44e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 4.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 209 KPYECQECGKTFTLYPQLNRHQKIHTGKKPYMC--KKCDKGFFSRLELTQHKRIHTGKKSYEC-KECGKVFQLIFYFKEH 285
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 286 ERIHTGKKPYECKECGKAFSvcgqlTRHQKIHTGVKPYEckecgktFRLSFYLTEHRRTHAGKK------PYECKECGKS 359
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPS-----SRDPQLPDLLSISN-------LRNNPLPGNNSSSVNTPQsnslhpPLPANSLSKD 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 360 FNVRGQLNRHKTIHTGIKPFACKVCEKAFSYSGDLRVHSRIHTGEKPYECKECGKAFMLRSVLTEHQRLHTGVKPYECKE 439
Cdd:COG5048  180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 440 CGKTFRVRSQISLHKKIHTDV-------KPYKCVRCGKTFRFGFYLTEHQR--IHTGE--KPYKCKE--CGKAFIRRGNL 506
Cdd:COG5048  260 SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 507 KEHLKIHSGLKPYDCKEC-------GKSFSRRGQFTEHQKIHTGVKPYKC--KECGKAFSRSVDLRIHQRIHTGEKPYEC 577
Cdd:COG5048  340 KRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNC 419

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 288557353 578 K--QCGKAFRLNSHLTEHQRIHTGEKPYECKVCRKAFRQ 614
Cdd:COG5048  420 KnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
477-502 7.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.48e-04
                          10        20
                  ....*....|....*....|....*.
gi 288557353  477 YLTEHQRIHTGEKPYKCKECGKAFIR 502
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 8.30e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 96.77  E-value: 8.30e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 288557353    5 LVTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSLG 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
6-47 1.61e-23

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 93.81  E-value: 1.61e-23
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 288557353     6 VTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSLGL 47
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 1.74e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.83  E-value: 1.74e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 288557353   6 VTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVSL 45
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-614 4.44e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 4.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 209 KPYECQECGKTFTLYPQLNRHQKIHTGKKPYMC--KKCDKGFFSRLELTQHKRIHTGKKSYEC-KECGKVFQLIFYFKEH 285
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 286 ERIHTGKKPYECKECGKAFSvcgqlTRHQKIHTGVKPYEckecgktFRLSFYLTEHRRTHAGKK------PYECKECGKS 359
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPS-----SRDPQLPDLLSISN-------LRNNPLPGNNSSSVNTPQsnslhpPLPANSLSKD 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 360 FNVRGQLNRHKTIHTGIKPFACKVCEKAFSYSGDLRVHSRIHTGEKPYECKECGKAFMLRSVLTEHQRLHTGVKPYECKE 439
Cdd:COG5048  180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 440 CGKTFRVRSQISLHKKIHTDV-------KPYKCVRCGKTFRFGFYLTEHQR--IHTGE--KPYKCKE--CGKAFIRRGNL 506
Cdd:COG5048  260 SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 507 KEHLKIHSGLKPYDCKEC-------GKSFSRRGQFTEHQKIHTGVKPYKC--KECGKAFSRSVDLRIHQRIHTGEKPYEC 577
Cdd:COG5048  340 KRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNC 419

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 288557353 578 K--QCGKAFRLNSHLTEHQRIHTGEKPYECKVCRKAFRQ 614
Cdd:COG5048  420 KnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
184-566 2.48e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 2.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 184 KCEKCGKVFSHSYQLTLHQRFHTGEKPYEC--QECGKTFTLYPQLNRHQKIHTGKKPYMCKKCDKGFFSrlELTQHKRIH 261
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNS--KASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 262 TGKKSYE---CKECGKVFQLIFYFKEHERIHTGKKPYECKECGKAFSVCGQ-----------------------LTRHQK 315
Cdd:COG5048  113 SSSNSNDnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplpanslskdpssnlslLISSNV 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 316 IHTGVKPYECKECGKTFRLSFYLTEHRRTHAgKKPYECKECgkSFNVRGQLNRHKTIHTGIKPFACKVCEKAFSYSGDLR 395
Cdd:COG5048  193 STSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 396 VHSRIHTG---------EKPYECKECGKAFMLRSVLTEHQR--LHTG--VKPYECKE--CGKTFRVRSQISLHKKIHTDV 460
Cdd:COG5048  270 SQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 461 KPYKCV--RCGKTFRFGF--YLTEHQRIHTGEKPYKCKE-----CGKAFIRRGNLKEHLKIHSGLKPYDCK--ECGKSFS 529
Cdd:COG5048  350 SPAKEKllNSSSKFSPLLnnEPPQSLQQYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFN 429

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 288557353 530 RRGQFTEHQKIHTGVKPYKCKECGKAFSRSVDLRIHQ 566
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
264-626 3.21e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 3.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 264 KKSYECKECGKVFQLIFYFKEHERIHTGKKPYEC--KECGKAFSVCGQLTRHQKIHTGVKPYECKecgKTFRLSFYLTEH 341
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 342 R-RTHAGKKP-YECKECGKSFNvrgQLNRHKTIHTGIKP--FACKVCEKAFSYSGDLRVHSRIHtGEKPYECKeCGKAFM 417
Cdd:COG5048  108 SsLSSSSSNSnDNNLLSSHSLP---PSSRDPQLPDLLSIsnLRNNPLPGNNSSSVNTPQSNSLH-PPLPANSL-SKDPSS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 418 LRSVLTEHQRLHTGVKPYECKECGKTFRVRSQISLHKKIHtDVKPYKCVRCGKTFRFGFYLTEHQRIHTGEKPYKCKECG 497
Cdd:COG5048  183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLEN-SSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288557353 498 kafiRRGNLKEHLKIHSGLKPYdckecgkSFSRRGQFTehqkihtgvkPYKCKECGKAFSRSVDLRIHQR--IHTGE--K 573
Cdd:COG5048  262 ----RSSLPTASSQSSSPNESD-------SSSEKGFSL----------PIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 288557353 574 PYEC--KQCGKAFRLNSHLTEHQRIHTGEKPYECK--VCRKAFRQYSHLYQHQKTHN 626
Cdd:COG5048  321 PFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQ 377
zf-H2C2_2 pfam13465
Zinc-finger double domain;
477-502 7.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.48e-04
                          10        20
                  ....*....|....*....|....*.
gi 288557353  477 YLTEHQRIHTGEKPYKCKECGKAFIR 502
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
393-416 1.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.26e-03
                          10        20
                  ....*....|....*....|....
gi 288557353  393 DLRVHSRIHTGEKPYECKECGKAF 416
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
589-614 1.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|....*.
gi 288557353  589 HLTEHQRIHTGEKPYECKVCRKAFRQ 614
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
561-584 1.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.69e-03
                          10        20
                  ....*....|....*....|....
gi 288557353  561 DLRIHQRIHTGEKPYECKQCGKAF 584
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-305 2.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.00e-03
                          10        20
                  ....*....|....*....|....*
gi 288557353  281 YFKEHERIHTGKKPYECKECGKAFS 305
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
505-530 3.86e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.86e-03
                          10        20
                  ....*....|....*....|....*.
gi 288557353  505 NLKEHLKIHSGLKPYDCKECGKSFSR 530
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
310-332 5.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.03e-03
                          10        20
                  ....*....|....*....|...
gi 288557353  310 LTRHQKIHTGVKPYECKECGKTF 332
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
536-558 7.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.60e-03
                          10        20
                  ....*....|....*....|...
gi 288557353  536 EHQKIHTGVKPYKCKECGKAFSR 558
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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