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Conserved domains on  [gi|1654220529|ref|NP_001164425|]
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lactosylceramide 4-alpha-galactosyltransferase [Mus musculus]

Protein Classification

Gly_transf_sug and Gb3_synth domain-containing protein( domain architecture ID 10517332)

Gly_transf_sug and Gb3_synth domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gb3_synth pfam04572
Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of ...
 217-344 9.57e-61

Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilize UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region.


:

Pssm-ID: 428017  Cd Length: 130  Bit Score: 190.92  E-value: 9.57e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220529 217 AFERKHEFLALCLHDFVANYNGWIWGHQGPQLLTRVFKKWCSIQSLEK--SHACRGVTALPPEAFYPIPWQNWKKYFEDI 294
Cdd:pfam04572   1 AFDKGHPFLELCLRDFVENYNGDEWGHNGPGLLTRVLKKFCNTSDLKAmeRVRCRGFTVLPPEAFYPIPYPNWKRFFEPE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1654220529 295 SPEELTQLLNATYAVHVWNKKSQGTHLEATSKALLAQLHARYCPTTHRAM 344
Cdd:pfam04572  81 DLEETMKLTKDSYAVHLWNKLSKGEPLKVGSNSLYARLARKHCPRTYAAA 130
Gly_transf_sug pfam04488
Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short ...
 89-209 1.15e-20

Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.


:

Pssm-ID: 398274 [Multi-domain]  Cd Length: 93  Bit Score: 85.08  E-value: 1.15e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220529  89 FMCSVESAARAHPESQVVVLMKGLprdttaqprnlgisllscfpnvwIRPLDLQELFEDTPlaaWYSEARHRWEPYQLpv 168
Cdd:pfam04488   4 VMKAIESLIKLHPDYCYVVLSDDL-----------------------DFALDINFLKSDTP---WFLEAYSLLPLFIA-- 55

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1654220529 169 LSDASRIALLWKFGGIYLDTDFIVLKNLlnltNTLGIQSRY 209
Cdd:pfam04488  56 KSDLLRYAILYKYGGIYLDTDVIPLKSL----NSIGAQERF 92
 
Name Accession Description Interval E-value
Gb3_synth pfam04572
Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of ...
 217-344 9.57e-61

Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilize UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region.


Pssm-ID: 428017  Cd Length: 130  Bit Score: 190.92  E-value: 9.57e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220529 217 AFERKHEFLALCLHDFVANYNGWIWGHQGPQLLTRVFKKWCSIQSLEK--SHACRGVTALPPEAFYPIPWQNWKKYFEDI 294
Cdd:pfam04572   1 AFDKGHPFLELCLRDFVENYNGDEWGHNGPGLLTRVLKKFCNTSDLKAmeRVRCRGFTVLPPEAFYPIPYPNWKRFFEPE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1654220529 295 SPEELTQLLNATYAVHVWNKKSQGTHLEATSKALLAQLHARYCPTTHRAM 344
Cdd:pfam04572  81 DLEETMKLTKDSYAVHLWNKLSKGEPLKVGSNSLYARLARKHCPRTYAAA 130
Gly_transf_sug pfam04488
Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short ...
 89-209 1.15e-20

Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.


Pssm-ID: 398274 [Multi-domain]  Cd Length: 93  Bit Score: 85.08  E-value: 1.15e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220529  89 FMCSVESAARAHPESQVVVLMKGLprdttaqprnlgisllscfpnvwIRPLDLQELFEDTPlaaWYSEARHRWEPYQLpv 168
Cdd:pfam04488   4 VMKAIESLIKLHPDYCYVVLSDDL-----------------------DFALDINFLKSDTP---WFLEAYSLLPLFIA-- 55

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1654220529 169 LSDASRIALLWKFGGIYLDTDFIVLKNLlnltNTLGIQSRY 209
Cdd:pfam04488  56 KSDLLRYAILYKYGGIYLDTDVIPLKSL----NSIGAQERF 92
OCH1 COG3774
Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];
170-229 9.71e-08

Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442988 [Multi-domain]  Cd Length: 136  Bit Score: 50.27  E-value: 9.71e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1654220529 170 SDASRIALLWKFGGIYLDTDFIVLKNLLNLTNT----LGIQ--SRYVLNGAFLAFERKHEFLALCL 229
Cdd:COG3774    70 ADLFRLLLLYKYGGIYLDIDVECLKPLDPLLDGddlfLGYEdpPPGIISNGFIAAEPGHPFLKKAL 135
 
Name Accession Description Interval E-value
Gb3_synth pfam04572
Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of ...
 217-344 9.57e-61

Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilize UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region.


Pssm-ID: 428017  Cd Length: 130  Bit Score: 190.92  E-value: 9.57e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220529 217 AFERKHEFLALCLHDFVANYNGWIWGHQGPQLLTRVFKKWCSIQSLEK--SHACRGVTALPPEAFYPIPWQNWKKYFEDI 294
Cdd:pfam04572   1 AFDKGHPFLELCLRDFVENYNGDEWGHNGPGLLTRVLKKFCNTSDLKAmeRVRCRGFTVLPPEAFYPIPYPNWKRFFEPE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1654220529 295 SPEELTQLLNATYAVHVWNKKSQGTHLEATSKALLAQLHARYCPTTHRAM 344
Cdd:pfam04572  81 DLEETMKLTKDSYAVHLWNKLSKGEPLKVGSNSLYARLARKHCPRTYAAA 130
Gly_transf_sug pfam04488
Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short ...
 89-209 1.15e-20

Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.


Pssm-ID: 398274 [Multi-domain]  Cd Length: 93  Bit Score: 85.08  E-value: 1.15e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1654220529  89 FMCSVESAARAHPESQVVVLMKGLprdttaqprnlgisllscfpnvwIRPLDLQELFEDTPlaaWYSEARHRWEPYQLpv 168
Cdd:pfam04488   4 VMKAIESLIKLHPDYCYVVLSDDL-----------------------DFALDINFLKSDTP---WFLEAYSLLPLFIA-- 55

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1654220529 169 LSDASRIALLWKFGGIYLDTDFIVLKNLlnltNTLGIQSRY 209
Cdd:pfam04488  56 KSDLLRYAILYKYGGIYLDTDVIPLKSL----NSIGAQERF 92
OCH1 COG3774
Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];
170-229 9.71e-08

Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442988 [Multi-domain]  Cd Length: 136  Bit Score: 50.27  E-value: 9.71e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1654220529 170 SDASRIALLWKFGGIYLDTDFIVLKNLLNLTNT----LGIQ--SRYVLNGAFLAFERKHEFLALCL 229
Cdd:COG3774    70 ADLFRLLLLYKYGGIYLDIDVECLKPLDPLLDGddlfLGYEdpPPGIISNGFIAAEPGHPFLKKAL 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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