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Conserved domains on  [gi|283135246|ref|NP_001164376|]
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zinc finger protein 736 isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-63 3.42e-35

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 124.24  E-value: 3.42e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246     4 LTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLVSLGLAIFKPDLMTCLEQRKEPW 63
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-383 3.11e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 3.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246 227 KPYKCEGCGKTFTCSSTLVKHKR--NHTG--DRPYKCEE--CGKAFKCFSDLTNHKRIHTGEKPYKCEECN--------K 292
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNssskfsplL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246 293 AYRWFSDLAKHKIIHTgDKPYTC--NECGKAFKWFSALSKHKRIHTGEKPY--ICEECGKAFTRSSTLFNHKRIHMEERP 368
Cdd:COG5048  368 NNEPPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAP 446

                        170
                 ....*....|....*
gi 283135246 369 YKCEECSKTFKCFSD 383
Cdd:COG5048  447 LLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-407 6.66e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.66e-03
                          10        20
                  ....*....|....*....|....*
gi 283135246  383 DLTNHKRIHTGEKPYKCEECGKASS 407
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-63 3.42e-35

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 124.24  E-value: 3.42e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246     4 LTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLVSLGLAIFKPDLMTCLEQRKEPW 63
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.53e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.15  E-value: 1.53e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 283135246    3 VLTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLVSLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 2.63e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 83.37  E-value: 2.63e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 283135246   4 LTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLVSL 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-383 3.11e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 3.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246 227 KPYKCEGCGKTFTCSSTLVKHKR--NHTG--DRPYKCEE--CGKAFKCFSDLTNHKRIHTGEKPYKCEECN--------K 292
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNssskfsplL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246 293 AYRWFSDLAKHKIIHTgDKPYTC--NECGKAFKWFSALSKHKRIHTGEKPY--ICEECGKAFTRSSTLFNHKRIHMEERP 368
Cdd:COG5048  368 NNEPPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAP 446

                        170
                 ....*....|....*
gi 283135246 369 YKCEECSKTFKCFSD 383
Cdd:COG5048  447 LLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
244-268 1.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|....*
gi 283135246  244 LVKHKRNHTGDRPYKCEECGKAFKC 268
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-407 6.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.66e-03
                          10        20
                  ....*....|....*....|....*
gi 283135246  383 DLTNHKRIHTGEKPYKCEECGKASS 407
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-63 3.42e-35

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 124.24  E-value: 3.42e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246     4 LTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLVSLGLAIFKPDLMTCLEQRKEPW 63
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.53e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.15  E-value: 1.53e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 283135246    3 VLTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLVSLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 2.63e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 83.37  E-value: 2.63e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 283135246   4 LTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLVSL 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-383 3.11e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 3.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246 227 KPYKCEGCGKTFTCSSTLVKHKR--NHTG--DRPYKCEE--CGKAFKCFSDLTNHKRIHTGEKPYKCEECN--------K 292
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNssskfsplL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246 293 AYRWFSDLAKHKIIHTgDKPYTC--NECGKAFKWFSALSKHKRIHTGEKPY--ICEECGKAFTRSSTLFNHKRIHMEERP 368
Cdd:COG5048  368 NNEPPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAP 446

                        170
                 ....*....|....*
gi 283135246 369 YKCEECSKTFKCFSD 383
Cdd:COG5048  447 LLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
256-411 8.33e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 8.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246 256 PYKCEECGKAFKCFSDLTNHKR--IHTGE--KPYKCEE--CNKAYRWFSDLAKHKIIHTGDKPYTC--NECGKAF----- 322
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFsplln 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246 323 -KWFSALSKHKRIHTgEKPYICE--ECGKAFTRSSTLFNHKRIHMEERPY--KCEECSKTFKCFSDLTNHKRIHTGEKPY 397
Cdd:COG5048  369 nEPPQSLQQYKDLKN-DKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*.
gi 283135246 398 KCEECGK--ASSWFSH 411
Cdd:COG5048  448 LCSILKSfrRDLDLSN 463
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-427 1.05e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246 199 RCYKCEECGKAFKKFSNLTEHKRVHTGEKPYKC--EGCGKTFTCSSTLVKHKRNHTGD----------------RPYKCE 260
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNpsdlnskslplsnskaSSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246 261 ECGKAF----KCFSDLTNHKRIHTGEKPY---------KCEECNK-----------------------AYRWFSDLAKHK 304
Cdd:COG5048  112 SSSSNSndnnLLSSHSLPPSSRDPQLPDLlsisnlrnnPLPGNNSssvntpqsnslhpplpanslskdPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246 305 IIHTGDKPYTCNECGKAFKWFSALSKHKRIH----------------------------TGEKPYICEECGKAF-TRSST 355
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssslplttnsqlspksllsqspsslssSDSSSSASESPRSSLpTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246 356 LFNHKRIHMEER-----PYKCEECSKTFKCFSDLTNHKR--IHTGE--KPYKCEE--CGKASSWFSHLIRHKRIHTREKL 424
Cdd:COG5048  272 SSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351


                 ...
gi 283135246 425 HKC 427
Cdd:COG5048  352 AKE 354
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 225-304 4.77e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 4.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246 225 GEKPYKCE--GCGKTFTCSSTLVKHKRNHtgdrpykceECGKAFKCFSDLTNHKRIHTGEKPYKCEECNKAYRWFSDLAK 302
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHG---------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 283135246 303 HK 304
Cdd:COG5189  417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 253-332 8.00e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 8.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246 253 GDRPYKCE--ECGKAFKCFSDLTNHKrihtgekpyKCEECNKAYRWFSDLAKHKIIHTGDKPYTCNECGKAFKWFSALSK 330
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 283135246 331 HK 332
Cdd:COG5189  417 HR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
118-361 1.49e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246 118 QSVGNCKGQKSSYNGLHQCLSATHSKTCQCNKCGRGF-------QLCSIFTEHKDIFSRekcHKCEECGKDCRLFSDFTR 190
Cdd:COG5048  231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTassqsssPNESDSSSEKGFSLP---IKSKQCNISFSRSSPLTR 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246 191 HK--KIHTVERCYKCEE----CGKAFKKFSNLTEHKRVHTGEKPYKCegcgKTFTCSStlvKHKRNHTGDRPykceecgk 264
Cdd:COG5048  308 HLrsVNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKE----KLLNSSS---KFSPLLNNEPP-------- 372

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246 265 afkcfSDLTNHKRIHTGEKpyKCEECNKAYRWFSD---LAKHKIIHTGDKPYTCN--ECGKAFKWFSALSKHKRIHTgEK 339
Cdd:COG5048  373 -----QSLQQYKDLKNDKK--SETLSNSCIRNFKRdsnLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT-NH 444

                        250       260
                 ....*....|....*....|..
gi 283135246 340 PYICEECGKAFTRSSTLFNHKR 361
Cdd:COG5048  445 APLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 281-360 5.31e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 5.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246 281 GEKPYKCE--ECNKAYRWFSDLAKHKIiHtgdkpytcNECGKAFKWFSALSKHKRIHTGEKPYICEECGKAFTRSSTLFN 358
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-H--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 283135246 359 HK 360
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
244-268 1.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|....*
gi 283135246  244 LVKHKRNHTGDRPYKCEECGKAFKC 268
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
254-316 1.04e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.04e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 283135246 254 DRPYKCEECGKAFKCFSDLTNHKRIHTGEKPYKCEEC---NKAYRWfSDLAKHKIIHTGDKPYTCN 316
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSgcdKSFSRP-LELSRHLRTHHNNPSDLNS 95
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
310-388 1.19e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283135246 310 DKPYTCNECGKAFKWFSALSKHKRIHTGEKPYIC--EECGKAFTRSSTLFNHKRIHMEERPYKCE--ECSKTFKCFSDLT 385
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSksLPLSNSKASSSSL 110


                 ...
gi 283135246 386 NHK 388
Cdd:COG5048  111 SSS 113
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-240 1.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.32e-03
                          10        20
                  ....*....|....*....|....*.
gi 283135246  215 NLTEHKRVHTGEKPYKCEGCGKTFTC 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
327-352 5.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.42e-03
                          10        20
                  ....*....|....*....|....*.
gi 283135246  327 ALSKHKRIHTGEKPYICEECGKAFTR 352
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
299-323 5.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.52e-03
                          10        20
                  ....*....|....*....|....*
gi 283135246  299 DLAKHKIIHTGDKPYTCNECGKAFK 323
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-407 6.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.66e-03
                          10        20
                  ....*....|....*....|....*
gi 283135246  383 DLTNHKRIHTGEKPYKCEECGKASS 407
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
356-380 8.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 8.59e-03
                          10        20
                  ....*....|....*....|....*
gi 283135246  356 LFNHKRIHMEERPYKCEECSKTFKC 380
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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