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Conserved domains on  [gi|282158059|ref|NP_001164075|]
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interleukin-12 receptor subunit beta-1 precursor [Rattus norvegicus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10440908)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  19576999|9837732|8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
472-555 1.60e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 1.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158059  472 PRHVSVRNHTEDSVSVEWTASqlSTCPGVLTQYVVRCEAEDGTWES-ELLVPPTKTQVTLNSLRSRVVYKVQVRADTAML 550
Cdd:pfam00041   3 PSNLTVTDVTSTSLTVSWTPP--PDGNGPITGYEVEYRPKNSGEPWnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ....*
gi 282158059  551 PGSWS 555
Cdd:pfam00041  81 EGPPS 85
 
Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
472-555 1.60e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 1.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158059  472 PRHVSVRNHTEDSVSVEWTASqlSTCPGVLTQYVVRCEAEDGTWES-ELLVPPTKTQVTLNSLRSRVVYKVQVRADTAML 550
Cdd:pfam00041   3 PSNLTVTDVTSTSLTVSWTPP--PDGNGPITGYEVEYRPKNSGEPWnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ....*
gi 282158059  551 PGSWS 555
Cdd:pfam00041  81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 470-560 3.33e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 3.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158059 470 GTPRHVSVRNHTEDSVSVEWTASQLSTCPgvLTQYVVR-CEAEDGTWESELLVPPTKTQVTLNSLRSRVVYKVQVRADTA 548
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGP--ITGYVVEyREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|..
gi 282158059 549 MLPGSWSRPQRF 560
Cdd:cd00063   80 GGESPPSESVTV 91
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 470-545 2.43e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 2.43e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 282158059   470 GTPRHVSVRNHTEDSVSVEWTASQLSTCPGVLTQYVVRCEAEDGTWEsELLVPPTKTQVTLNSLRSRVVYKVQVRA 545
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
470-603 5.62e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 43.45  E-value: 5.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158059 470 GTPRHVSVRNHTEDSVSVEWTAsqlSTCPGVLTQYVVRCEAEDGTWEsELLVPPTKTQVTLNSLRSRVVYKVQVRA-DTA 548
Cdd:COG3401  328 AAPSGLTATAVGSSSITLSWTA---SSDADVTGYNVYRSTSGGGTYT-KIAETVTTTSYTDTGLTPGTTYYYKVTAvDAA 403

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 282158059 549 mlpGSWSRPqrfSVEVQISRLSIVFASLGSfASVLLVGSLGYIGLNRAAWHLCPP 603
Cdd:COG3401  404 ---GNESAP---SEEVSATTASAASGESLT-ASVDAVPLTDVAGATAAASAASNP 451
 
Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
472-555 1.60e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 1.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158059  472 PRHVSVRNHTEDSVSVEWTASqlSTCPGVLTQYVVRCEAEDGTWES-ELLVPPTKTQVTLNSLRSRVVYKVQVRADTAML 550
Cdd:pfam00041   3 PSNLTVTDVTSTSLTVSWTPP--PDGNGPITGYEVEYRPKNSGEPWnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ....*
gi 282158059  551 PGSWS 555
Cdd:pfam00041  81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 470-560 3.33e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 3.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158059 470 GTPRHVSVRNHTEDSVSVEWTASQLSTCPgvLTQYVVR-CEAEDGTWESELLVPPTKTQVTLNSLRSRVVYKVQVRADTA 548
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGP--ITGYVVEyREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|..
gi 282158059 549 MLPGSWSRPQRF 560
Cdd:cd00063   80 GGESPPSESVTV 91
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 470-545 2.43e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 2.43e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 282158059   470 GTPRHVSVRNHTEDSVSVEWTASQLSTCPGVLTQYVVRCEAEDGTWEsELLVPPTKTQVTLNSLRSRVVYKVQVRA 545
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
470-603 5.62e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 43.45  E-value: 5.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158059 470 GTPRHVSVRNHTEDSVSVEWTAsqlSTCPGVLTQYVVRCEAEDGTWEsELLVPPTKTQVTLNSLRSRVVYKVQVRA-DTA 548
Cdd:COG3401  328 AAPSGLTATAVGSSSITLSWTA---SSDADVTGYNVYRSTSGGGTYT-KIAETVTTTSYTDTGLTPGTTYYYKVTAvDAA 403

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 282158059 549 mlpGSWSRPqrfSVEVQISRLSIVFASLGSfASVLLVGSLGYIGLNRAAWHLCPP 603
Cdd:COG3401  404 ---GNESAP---SEEVSATTASAASGESLT-ASVDAVPLTDVAGATAAASAASNP 451
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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