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Conserved domains on  [gi|281362560|ref|NP_001163728|]
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uncharacterized protein Dmel_CG10669, isoform B [Drosophila melanogaster]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10544459)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  22803940|11361095|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 4-80 2.06e-09

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


:

Pssm-ID: 462262  Cd Length: 75  Bit Score: 54.77  E-value: 2.06e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362560    4 TCRVCGCD-DGRYWIETPVEkyAEKTFVQLLVELTRIEVVmaQAEKFPQWLCYACAEKLESTYDFVLQARRTHELWLQ 80
Cdd:pfam07776   1 VCRLCLDEsDELIPIFDPSD--SEKTLAEILEDCTGIELD--PNDLLPKQICERCLSKLQEFYSFRERCLESQELLQE 74
zf-H2C2_2 pfam13465
Zinc-finger double domain;
893-918 1.07e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 281362560  893 ELKVHRRKHTGERPYQCTFCDKDFAR 918
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
866-889 1.81e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.81e-04
                          10        20
                  ....*....|....*....|....
gi 281362560  866 LNIHMRRHTGEKPFKCDLCDMRFT 889
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 4-80 2.06e-09

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 54.77  E-value: 2.06e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362560    4 TCRVCGCD-DGRYWIETPVEkyAEKTFVQLLVELTRIEVVmaQAEKFPQWLCYACAEKLESTYDFVLQARRTHELWLQ 80
Cdd:pfam07776   1 VCRLCLDEsDELIPIFDPSD--SEKTLAEILEDCTGIELD--PNDLLPKQICERCLSKLQEFYSFRERCLESQELLQE 74
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 5-80 5.85e-06

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 44.81  E-value: 5.85e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362560     5 CRVCGCDDGRYwiETPVEKYAEKTFVQLLVELTRIEVvmAQAEKFPQWLCYACAEKLESTYDFVLQARRTHELWLQ 80
Cdd:smart00868   2 CRLCLSESENL--VSIFDESSEASLAEKIEECTGIEI--EPDDGLPKVICGDCLEKLESFHKFRERCRESDELLRE 73
zf-H2C2_2 pfam13465
Zinc-finger double domain;
893-918 1.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 281362560  893 ELKVHRRKHTGERPYQCTFCDKDFAR 918
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
866-889 1.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.81e-04
                          10        20
                  ....*....|....*....|....
gi 281362560  866 LNIHMRRHTGEKPFKCDLCDMRFT 889
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
877-930 7.13e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 7.13e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 281362560 877 KPFKCDLCDMRFTVHYELKVHRRKHTGERPYQCTF--CDKDFARPDKLRRHVFMHN 930
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHH 87
 
Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 4-80 2.06e-09

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 54.77  E-value: 2.06e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281362560    4 TCRVCGCD-DGRYWIETPVEkyAEKTFVQLLVELTRIEVVmaQAEKFPQWLCYACAEKLESTYDFVLQARRTHELWLQ 80
Cdd:pfam07776   1 VCRLCLDEsDELIPIFDPSD--SEKTLAEILEDCTGIELD--PNDLLPKQICERCLSKLQEFYSFRERCLESQELLQE 74
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 5-80 5.85e-06

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 44.81  E-value: 5.85e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281362560     5 CRVCGCDDGRYwiETPVEKYAEKTFVQLLVELTRIEVvmAQAEKFPQWLCYACAEKLESTYDFVLQARRTHELWLQ 80
Cdd:smart00868   2 CRLCLSESENL--VSIFDESSEASLAEKIEECTGIEI--EPDDGLPKVICGDCLEKLESFHKFRERCRESDELLRE 73
zf-H2C2_2 pfam13465
Zinc-finger double domain;
893-918 1.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 281362560  893 ELKVHRRKHTGERPYQCTFCDKDFAR 918
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
866-889 1.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.81e-04
                          10        20
                  ....*....|....*....|....
gi 281362560  866 LNIHMRRHTGEKPFKCDLCDMRFT 889
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
877-930 7.13e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 7.13e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 281362560 877 KPFKCDLCDMRFTVHYELKVHRRKHTGERPYQCTF--CDKDFARPDKLRRHVFMHN 930
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHH 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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