|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
102-527 |
7.41e-63 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 210.78 E-value: 7.41e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 102 MGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLSMWISNAACTAMMCPIIQAVLEELQAQGvckinhe 181
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEK------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 182 pqyqivggnkknnedeppyPTKITLCYYLGIAYASSLGGCGTIIGTATNLTFKGIYEarfKNSTEQMDFPTFMFYSVPSM 261
Cdd:COG0471 74 -------------------RSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLE---EATGIPISFFEWMLVGLPVA 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 262 LVYTLLTFVFLQWhfmgLWRPKSKEAQEvqrgregadvAKKVIDQRYKDLGPMSIHEIQVMILFIFMVVMYFTRKP-GIF 340
Cdd:COG0471 132 LVGLLLLWLVLYR----LLPPEIKEVPG----------SKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLhGIP 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 341 LGWAdllnskdirnsmpTIFVVVMCFMlpanyaflryctrrggpvptgptPSLITWKFIQTKVPWGLVFLLGGGFALAEG 420
Cdd:COG0471 198 IAVV-------------ALLGAVLLLL-----------------------TGVLTWKDAYKSIPWGVLLLFGGGLALGAA 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 421 SKQSGMAKLIGNALIG-LKVLPNSVLLLVVILVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLACSMAF 499
Cdd:COG0471 242 LEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAF 321
|
410 420
....*....|....*....|....*...
gi 281366409 500 HLPVSTPPNALVAGYANIRTKDMAIAGI 527
Cdd:COG0471 322 LLPVGTPPNAIVYGSGYYKFKDFLKVGL 349
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
50-527 |
2.10e-53 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 186.25 E-value: 2.10e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 50 MYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGIMSSDQTCRLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVG 129
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 130 CSPRRLHFGLIMVTMFLSMWISNAACTAMMCPIIQAVLEELQAQGVCkinhepqyqivggnkknnedeppyptkitlcYY 209
Cdd:cd01115 81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSR-------------------------------LL 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 210 LGIAYASSLGGCGTIIGTATNLTFKGIYEARFKNSTEQMDFPTFMFYSVPSMLVYTLLTFVFLqwhfmglwrpkskeaqe 289
Cdd:cd01115 130 MPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQGFSFFEFTPIGLPLLIIGLLYLWFIFRLA----------------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 290 vqrgregadvakkvidqrykdlgpmsiheiqvMILFIFMVVMYFTRKPGIFlgwadllnskdirnSMPTIFVVVMCFMLp 369
Cdd:cd01115 193 --------------------------------VLIITIVLLAALAAITGLL--------------PVSVAIAIGAIVLV- 225
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 370 anyaflryctrrggpvptgpTPSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALI-GLKVLPNSVLLLV 448
Cdd:cd01115 226 --------------------FGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALIsLLGGLPPFAILLL 285
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281366409 449 VILVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLACSMAFHLPVSTPPNALVAGYANIRTKDMAIAGI 527
Cdd:cd01115 286 LCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGL 364
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
20-527 |
2.78e-49 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 177.56 E-value: 2.78e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 20 ANHWK--GLVVFLVPLLCLPVMLLNEGAEFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGI----MSSDQTCRLY 93
Cdd:pfam00939 2 TLWWKllALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGtllaKALSWALSGF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 94 FKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLimVTMFLSMWISNAACTAMMCPIIQAVLEELQAQ 173
Cdd:pfam00939 82 SSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRTLGLGYGL--VFSDLLLAPATPSNTARAGGIVFPIIMSLPPA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 174 gvckinhepqyqivggnkKNNEDEPPYPTKITLCYYLGIAYASSLGGCGTIIGTATNLTFKGIYEarfKNSTEQMDFPTF 253
Cdd:pfam00939 160 ------------------FGSDPEKGSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMN---SILGVTITWASW 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 254 MFYSVPSMLVYTLLTFVFLQWHFMGlwrpkskeaqEVQRGREGADVAKKvidqRYKDLGPMSIHEIQVMILFIFMVVMYF 333
Cdd:pfam00939 219 FLAAIPPGVILLLLAPLLLYVLYPP----------EIKSVPDAKAIAKT----ELKELGPMTFREKALLGLFVLLLLLWI 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 334 TRkpgiflgwadllNSKDIRNSMPTIFVVVMCFMLPanyaflryctrrggpvptgptpsLITWKFI-QTKVPWGLVFLLG 412
Cdd:pfam00939 285 FG------------GSLNIDATTVAIIGLALMLLLR-----------------------ILDWKDIvKNKGAWNTLIWLG 329
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 413 GGFALAEGSKQSGMAKLIGNALIGL--KVLPNSVLLLVVILVAVFLTAFSSNVAIANIIIPVLAEMSLAI-EIHPLYLIL 489
Cdd:pfam00939 330 GLIMLANGLERSGFIEWLGNTLSTSlsGFSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIpGAPPLLAAL 409
|
490 500 510
....*....|....*....|....*....|....*....
gi 281366409 490 PAGLACS-MAFHLPVSTPPNALVAGYANIRTKDMAIAGI 527
Cdd:pfam00939 410 LLGFAISlGGFLTPYGTGPGPIYFGSGYLKVKDWWRIGA 448
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
52-527 |
3.11e-44 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 162.90 E-value: 3.11e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 52 LLLVMAIFWVTEALPLYVTSMIPI-VAFPIMGIMSSDQTCRL--YFKDTLV-MFMGGIMVALAVEYCNLHKRLALRVIQI 127
Cdd:TIGR00785 16 IFVAAIVGWILEPLPLPVTALLAIpIIAVLLGVLSAFKFKNAlsGFADPTIwLFFGAFILATALVKTGLGKRIAYKLVGK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 128 VG-CSPRRLHFGLIMVTMFLSMWISNAACT-AMMCPIIQAVLEELQaqgvckinhepqyqivggnkknnEDEPPYPTKIT 205
Cdd:TIGR00785 96 MGgTTLGLGYFLVFLETLLAPMWPSNTARAgGILLPIIKSLLPLLG-----------------------SKPEKSPRKIG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 206 LCYYLGIAYASSLGGCGTIIGTATNLTFKGIYearFKNSTEQMDFPTFMFYSVPSMLVYTLLTFVFLQWHFmglwRPKSK 285
Cdd:TIGR00785 153 KYLMLGIAYSASIGSSGFLTGSAPNALAAGIL---SKILGIQISWGDWFLAGLPLGIILLLLVPLLLYVLF----PPELK 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 286 EAQEVQRgregadvakkVIDQRYKDLGPMSIHEIQVMILFIFMVVMYFTrkpGIFLGwadllnskdIRNSMPTIFVVVMC 365
Cdd:TIGR00785 226 LKDEVDL----------WAKEELEEMGPMSFREKALLGIFLLALLLWIF---GGSLG---------INASVVALLAVVLM 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 366 FMLpanyaflryctrrggpvptgptpSLITWKFIQT-KVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALIG--LKVLPN 442
Cdd:TIGR00785 284 LFL-----------------------GIVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGilDGLSPT 340
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 443 SVLLLVVILVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLACS-MAFHLPVSTPPNALVAGYANIRTKD 521
Cdd:TIGR00785 341 IAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASlMGFLTPYATPPNAIAYGSGYVKIKD 420
|
....*.
gi 281366409 522 MAIAGI 527
Cdd:TIGR00785 421 MWRVGA 426
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
102-527 |
7.41e-63 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 210.78 E-value: 7.41e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 102 MGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLSMWISNAACTAMMCPIIQAVLEELQAQGvckinhe 181
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEK------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 182 pqyqivggnkknnedeppyPTKITLCYYLGIAYASSLGGCGTIIGTATNLTFKGIYEarfKNSTEQMDFPTFMFYSVPSM 261
Cdd:COG0471 74 -------------------RSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLE---EATGIPISFFEWMLVGLPVA 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 262 LVYTLLTFVFLQWhfmgLWRPKSKEAQEvqrgregadvAKKVIDQRYKDLGPMSIHEIQVMILFIFMVVMYFTRKP-GIF 340
Cdd:COG0471 132 LVGLLLLWLVLYR----LLPPEIKEVPG----------SKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLhGIP 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 341 LGWAdllnskdirnsmpTIFVVVMCFMlpanyaflryctrrggpvptgptPSLITWKFIQTKVPWGLVFLLGGGFALAEG 420
Cdd:COG0471 198 IAVV-------------ALLGAVLLLL-----------------------TGVLTWKDAYKSIPWGVLLLFGGGLALGAA 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 421 SKQSGMAKLIGNALIG-LKVLPNSVLLLVVILVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLACSMAF 499
Cdd:COG0471 242 LEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAF 321
|
410 420
....*....|....*....|....*...
gi 281366409 500 HLPVSTPPNALVAGYANIRTKDMAIAGI 527
Cdd:COG0471 322 LLPVGTPPNAIVYGSGYYKFKDFLKVGL 349
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
50-527 |
2.10e-53 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 186.25 E-value: 2.10e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 50 MYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGIMSSDQTCRLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVG 129
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 130 CSPRRLHFGLIMVTMFLSMWISNAACTAMMCPIIQAVLEELQAQGVCkinhepqyqivggnkknnedeppyptkitlcYY 209
Cdd:cd01115 81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSR-------------------------------LL 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 210 LGIAYASSLGGCGTIIGTATNLTFKGIYEARFKNSTEQMDFPTFMFYSVPSMLVYTLLTFVFLqwhfmglwrpkskeaqe 289
Cdd:cd01115 130 MPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQGFSFFEFTPIGLPLLIIGLLYLWFIFRLA----------------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 290 vqrgregadvakkvidqrykdlgpmsiheiqvMILFIFMVVMYFTRKPGIFlgwadllnskdirnSMPTIFVVVMCFMLp 369
Cdd:cd01115 193 --------------------------------VLIITIVLLAALAAITGLL--------------PVSVAIAIGAIVLV- 225
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 370 anyaflryctrrggpvptgpTPSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALI-GLKVLPNSVLLLV 448
Cdd:cd01115 226 --------------------FGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALIsLLGGLPPFAILLL 285
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281366409 449 VILVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLACSMAFHLPVSTPPNALVAGYANIRTKDMAIAGI 527
Cdd:cd01115 286 LCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGL 364
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
20-527 |
2.78e-49 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 177.56 E-value: 2.78e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 20 ANHWK--GLVVFLVPLLCLPVMLLNEGAEFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGI----MSSDQTCRLY 93
Cdd:pfam00939 2 TLWWKllALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGtllaKALSWALSGF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 94 FKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLimVTMFLSMWISNAACTAMMCPIIQAVLEELQAQ 173
Cdd:pfam00939 82 SSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRTLGLGYGL--VFSDLLLAPATPSNTARAGGIVFPIIMSLPPA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 174 gvckinhepqyqivggnkKNNEDEPPYPTKITLCYYLGIAYASSLGGCGTIIGTATNLTFKGIYEarfKNSTEQMDFPTF 253
Cdd:pfam00939 160 ------------------FGSDPEKGSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMN---SILGVTITWASW 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 254 MFYSVPSMLVYTLLTFVFLQWHFMGlwrpkskeaqEVQRGREGADVAKKvidqRYKDLGPMSIHEIQVMILFIFMVVMYF 333
Cdd:pfam00939 219 FLAAIPPGVILLLLAPLLLYVLYPP----------EIKSVPDAKAIAKT----ELKELGPMTFREKALLGLFVLLLLLWI 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 334 TRkpgiflgwadllNSKDIRNSMPTIFVVVMCFMLPanyaflryctrrggpvptgptpsLITWKFI-QTKVPWGLVFLLG 412
Cdd:pfam00939 285 FG------------GSLNIDATTVAIIGLALMLLLR-----------------------ILDWKDIvKNKGAWNTLIWLG 329
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 413 GGFALAEGSKQSGMAKLIGNALIGL--KVLPNSVLLLVVILVAVFLTAFSSNVAIANIIIPVLAEMSLAI-EIHPLYLIL 489
Cdd:pfam00939 330 GLIMLANGLERSGFIEWLGNTLSTSlsGFSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIpGAPPLLAAL 409
|
490 500 510
....*....|....*....|....*....|....*....
gi 281366409 490 PAGLACS-MAFHLPVSTPPNALVAGYANIRTKDMAIAGI 527
Cdd:pfam00939 410 LLGFAISlGGFLTPYGTGPGPIYFGSGYLKVKDWWRIGA 448
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
52-527 |
3.11e-44 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 162.90 E-value: 3.11e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 52 LLLVMAIFWVTEALPLYVTSMIPI-VAFPIMGIMSSDQTCRL--YFKDTLV-MFMGGIMVALAVEYCNLHKRLALRVIQI 127
Cdd:TIGR00785 16 IFVAAIVGWILEPLPLPVTALLAIpIIAVLLGVLSAFKFKNAlsGFADPTIwLFFGAFILATALVKTGLGKRIAYKLVGK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 128 VG-CSPRRLHFGLIMVTMFLSMWISNAACT-AMMCPIIQAVLEELQaqgvckinhepqyqivggnkknnEDEPPYPTKIT 205
Cdd:TIGR00785 96 MGgTTLGLGYFLVFLETLLAPMWPSNTARAgGILLPIIKSLLPLLG-----------------------SKPEKSPRKIG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 206 LCYYLGIAYASSLGGCGTIIGTATNLTFKGIYearFKNSTEQMDFPTFMFYSVPSMLVYTLLTFVFLQWHFmglwRPKSK 285
Cdd:TIGR00785 153 KYLMLGIAYSASIGSSGFLTGSAPNALAAGIL---SKILGIQISWGDWFLAGLPLGIILLLLVPLLLYVLF----PPELK 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 286 EAQEVQRgregadvakkVIDQRYKDLGPMSIHEIQVMILFIFMVVMYFTrkpGIFLGwadllnskdIRNSMPTIFVVVMC 365
Cdd:TIGR00785 226 LKDEVDL----------WAKEELEEMGPMSFREKALLGIFLLALLLWIF---GGSLG---------INASVVALLAVVLM 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 366 FMLpanyaflryctrrggpvptgptpSLITWKFIQT-KVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALIG--LKVLPN 442
Cdd:TIGR00785 284 LFL-----------------------GIVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGilDGLSPT 340
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 443 SVLLLVVILVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLYLILPAGLACS-MAFHLPVSTPPNALVAGYANIRTKD 521
Cdd:TIGR00785 341 IAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASlMGFLTPYATPPNAIAYGSGYVKIKD 420
|
....*.
gi 281366409 522 MAIAGI 527
Cdd:TIGR00785 421 MWRVGA 426
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
57-527 |
1.93e-29 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 120.05 E-value: 1.93e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 57 AIFWVTEALPLYVTSMIPIVAFPIMGIMSSDQTCRLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIvGCSPRRLH 136
Cdd:cd00625 1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARA-SKGSRRLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 137 FGLIMVTMFLSMWISNAACTAMMCPIIQAVLEELQAqgvckinhepqyqivggnkknnedeppyptKITLCYYLGIAYAS 216
Cdd:cd00625 80 LLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGL------------------------------SPPVPLLLALAFAA 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 217 SLGGCGTIIGTATNLtfkgiyearFKNSTEQMDFPTFMFYSVPSMLVYTLLTFVFLQWhfmgLWRPKSKEAQEVQRGREG 296
Cdd:cd00625 130 NIGGAATPIGNPPNL---------IIASLSGLGFLDFLAFMAPPALGLLLLLLGLLYL----LFRKKLLLPDEDKLTVLA 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 297 ADVAKKVIDQRYKDLgpmsiheiqvMILFIFMVVMYFTrkpgiflgwadllnskdirnSMPTIFVVVMCFMLpanyAFLR 376
Cdd:cd00625 197 EPLPARPLLKKFLLL----------ALLLLLLFVLLFF--------------------FLIPLGLIALLGAL----LLLL 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 377 YCTRRggpvptgptpslITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALIGLKVLPNSVLLLVVILVAVFL 456
Cdd:cd00625 243 LLVRG------------LDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALL 310
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281366409 457 TAFSSNVAIANIIIPVLAEMS-----LAIEIHPLYLILPAGLACSMAFHLPVSTPPNALVagyaNIRTKDMAIAGI 527
Cdd:cd00625 311 SNFISNVPTVALLLPIAASLAppepaWLALALGSTLGGNLTLIGSLANLIPLGAAENAGV----GISFGEFLKVGL 382
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
57-492 |
5.29e-27 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 112.02 E-value: 5.29e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 57 AIFWVTEALPLYVTSMIPIVAFPIMGIMSSDQTCRLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLH 136
Cdd:pfam03600 1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 137 FGLIMVTMFLSMWISNAACTAMMCPIIQAVLEELQAqgvckinhepqyqivggnkknnedePPYPtkitlcYYLGIAYAS 216
Cdd:pfam03600 81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRLGL-------------------------PPSP------LLIALAFAA 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 217 SLGGCGTIIGTATNLTFKGIYEARFknsteqMDFPTFMFYSVPSMLVYTLLTFVFLQWHFMGLWRPKSKEAQEVQRGReg 296
Cdd:pfam03600 130 NIGGTATPIGDPPNIIIASALGLSF------GDFGFFMFPPVGVALLLVGLLPLLLIFRKLLPVRKEEEAELEELRKR-- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 297 advakkvidqrykdlgpmsihEIQVMILFIFMVVMyftrkpgiflgwadllnskdirnsmptIFVVVMCFMLPANYAFlr 376
Cdd:pfam03600 202 ---------------------AIKDKLLLAISALV---------------------------LALVILGFLLLSVLAL-- 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 377 yctrrgGPVPTGPTPSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALIGLkvLPNSVLLLVVILVAVFL 456
Cdd:pfam03600 232 ------AGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGL--SGLLVALALILWLSALL 303
|
410 420 430
....*....|....*....|....*....|....*....
gi 281366409 457 TAFSSNVAIANIIIPVLAEMSLAI---EIHPLYLILPAG 492
Cdd:pfam03600 304 SAFISNVPTAALMAPIIVGMAPAAglgDPDPLAWALAVG 342
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
96-515 |
1.98e-09 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 59.76 E-value: 1.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 96 DTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLSMWISNAACTAMMCPIIQAVLEELqaqgv 175
Cdd:COG1055 54 NTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRL----- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 176 cKINHEPqyqivggnkknnedeppyptkitlcYYLGIAYASSLGGCGTIIGTATNLtfkGIYearfknSTEQMDFPTFMF 255
Cdd:COG1055 129 -GLNPVP-------------------------FLIAIVFAANIGGAATPIGNPTNI---MIA------SAGGLSFLDFLA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 256 YSVPSMLVYTLLTFVFLQWHFMGLWRPKSKEAQEVQRGREGADVAKKVIdqrykdlgpmsiheiqvmILFIFMVVMYFTr 335
Cdd:COG1055 174 NLFPPSLVSLLVTLLVLYLLFRKELPAAPDLEDDPKEAIKDRRLLRISL------------------LVLALLLVGFVL- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 336 kpGIFLGWadllnskdirnSMPTIFVVVMCFMLpanyAFLRYCTRRggpvptgptpslitwkfIQTKVPWGLVFLLGGGF 415
Cdd:COG1055 235 --HSFLGL-----------PPALIALLGAAVLL----LLARVDVRE-----------------VLKKVDWSTLLFFIGLF 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 416 ALAEGSKQSGMAKLIGNALIGLKVLPNSVLLLVVILVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPLY--LILPAGL 493
Cdd:COG1055 281 VVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNPEPLWlaLALGATL 360
|
410 420
....*....|....*....|..
gi 281366409 494 ACSMafhLPVSTPPNALVAGYA 515
Cdd:COG1055 361 GGNL---TPIGSAANVIVLGIA 379
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
52-272 |
5.29e-07 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 52.25 E-value: 5.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 52 LLLVMAIFWVTEALPLYVTSMIpIVAFPIMGIMSSDQtcRLYFK----DTLVMFMGGIMVALAVEYCNLHKRLALRVIQI 127
Cdd:cd00625 215 LLLLFVLLFFFLIPLGLIALLG-ALLLLLLLVRGLDP--EEVLKsvdwGTLLFFAGLFVLVGALESTGLLEWLAELLVAL 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 128 VGCSPRRLHFGLIMVTMFLSMWISNAACTAMMCPIIQAVLEELQAQgvckinhepqyqivggnkknnedeppyptkitlc 207
Cdd:cd00625 292 VGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLAPPEPAW---------------------------------- 337
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281366409 208 yyLGIAYASSLGGCGTIIGTATNLTFKGIyearFKNSTEQMDFPTFMFYSVPSMLVYTLLTFVFL 272
Cdd:cd00625 338 --LALALGSTLGGNLTLIGSLANLIPLGA----AENAGVGISFGEFLKVGLPLTLLSLVVSLLYL 396
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
44-274 |
1.37e-06 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 50.54 E-value: 1.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 44 GAEFRCMYLLLVMAIFWVTEA---LPLYVTSMIPIVAFPIMGIMSSDQTCRLYFKDTLVMFMGGIMVALAVEYCNLHKRL 120
Cdd:COG0471 172 RREKIALAIFALTVLLWITGSlhgIPIAVVALLGAVLLLLTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWL 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 121 ALRVIQIV-GCSPRRLHFGLIMVTMFLSMWISNAACTAMMCPIIQAVLEELQAqgvckinhepqyqivggnkknnedePP 199
Cdd:COG0471 252 ADALLPLLgGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGV-------------------------NP 306
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281366409 200 YPtkitlcYYLGIAYASSLGGCgTIIGTATNLTFKGiyearfknsTEQMDFPTFMFYSVPSMLVYTLLTFVFLQW 274
Cdd:COG0471 307 LP------LALAVAFAASCAFL-LPVGTPPNAIVYG---------SGYYKFKDFLKVGLPLNLIGLVVLLLLGPL 365
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
391-529 |
6.24e-05 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 45.38 E-value: 6.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 391 PSLITWKFIQTKVPWGLVFLLGGGFALAEGSKQSGMAKLIGNALIGLKVLPNSVLLLVVILVAVFLTAFSSNVAIANIII 470
Cdd:pfam03600 25 LGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIMI 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 471 PVLAEMSLAIEIHPLYLILPAGLACSMAFHL-PVSTPPNALVAGYANIRTKDMAIAGIGP 529
Cdd:pfam03600 105 PIVLALARRLGLPPSPLLIALAFAANIGGTAtPIGDPPNIIIASALGLSFGDFGFFMFPP 164
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
96-277 |
7.48e-05 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 45.50 E-value: 7.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 96 DTLVMFMGGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLSMWISNAACTAMMCPIIQAVLEELQAQGV 175
Cdd:COG1055 271 STLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNPEPL 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 176 ckinhepqyqivggnkknnedeppyptkitlcyYLGIAYASSLGGCGTIIGTATNLTFKGIYEARfknsTEQMDFPTFMF 255
Cdd:COG1055 351 ---------------------------------WLALALGATLGGNLTPIGSAANVIVLGIAEKK----GIKISFGEFLK 393
|
170 180
....*....|....*....|..
gi 281366409 256 YSVPSMLVYTLLTFVFLQWHFM 277
Cdd:COG1055 394 VGLPLTLLTLLIALLYLLLLYF 415
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
120-515 |
1.01e-04 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 44.94 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 120 LALRVIQIVGCSPRRLHFGLIMVTMFLSMWISNAACTAMMCPIIQAVLEELqaqgvckinhepqyqivggnkknnedepP 199
Cdd:cd01116 72 LAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVL----------------------------G 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 200 YPTKITLcyyLGIAYASSLGGCGTIIGTATNLTFkgiyearfkNSTEQMDFPTFMFYSVPSMLVYTLLTFVFLQWHFMGL 279
Cdd:cd01116 124 LNPVPVL---ISEVIAANIGGAATLIGDPPNIMI---------GSAAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNI 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 280 WRPKSKEAQEVQRGREGADVAKKVIdqrykdlgpmsihEIQVMILFIFMVVMYFTRK-PGIFLGW-----ADLLNSKDIR 353
Cdd:cd01116 192 LKAREEDVLALAELEPKYPIKDKVL-------------LLKSLTILTLVIIGFVLHSpLGVSLGWiallgALLLLLLADK 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 354 NSMPTIFvvvmcfmlpanyaflryctrrggpvptgptpslitwkfiqTKVPWGLVFLLGGGFALAEGSKQSGMAKLIGNA 433
Cdd:cd01116 259 LDFEDVL----------------------------------------SRVEWDTLLFFAGLFVLVGGLEELGIIEWIAEL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 434 LIGLKVLPNSVLLLVVILVAVFLTAFSSNVAIANIIIPVLAEMS--LAIEIHPLY--LILPAGLACSMafhLPVSTPPNA 509
Cdd:cd01116 299 LVGVILGRIAVAVILILWISALLSAFIDNIPVTATMIPIVKDLAsqLGIPLLPLWwaLALGACLGGNG---TLIGASANV 375
|
....*.
gi 281366409 510 LVAGYA 515
Cdd:cd01116 376 VAAGIA 381
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
48-272 |
2.66e-04 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 43.39 E-value: 2.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 48 RCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGIMSSDQTCRLYFK----DTLVMFMGGIMVALAVEYCNLHKRLALR 123
Cdd:cd01116 219 KSLTILTLVIIGFVLHSPLGVSLGWIALLGALLLLLLADKLDFEDVLSrvewDTLLFFAGLFVLVGGLEELGIIEWIAEL 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 124 VIQIVGcsprrlhfGLIMVTMFLSMWIS--------NAACTAMMCPIIQAVLEELQAqgvckinhepqyqivggnkknne 195
Cdd:cd01116 299 LVGVIL--------GRIAVAVILILWISallsafidNIPVTATMIPIVKDLASQLGI----------------------- 347
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281366409 196 dePPYPtkitlcYYLGIAYASSLGGCGTIIGTATNLTFKGIYEARfknsTEQMDFPTFMFYSVPSMLVYTLLTFVFL 272
Cdd:cd01116 348 --PLLP------LWWALALGACLGGNGTLIGASANVVAAGIAEQH----GYKISFWEFLKVGFPIMLVSLILATVYL 412
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
48-175 |
4.21e-04 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 42.68 E-value: 4.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366409 48 RCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGIMSSDQTCRLYFKDTLVMFMGGIMVALAVEYCNLHKRLALRVIQI 127
Cdd:pfam03600 207 LLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGL 286
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 281366409 128 VGcsPRRLHFGLIMVTMFLSMWISNAACTAMMCPIIQAVLEELQAQGV 175
Cdd:pfam03600 287 SG--LLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDP 332
|
|
| |
