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Conserved domains on  [gi|442628156|ref|NP_001162996|]
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cytoplasmic linker protein 190, isoform M [Drosophila melanogaster]

Protein Classification

kinesin family protein; PEPP family PH domain-containing protein( domain architecture ID 13652248)

kinesin family protein is a microtubule-dependent molecular motor that plays an important role in intracellular transport and in cell division and has ATPase-containing motor domain; similar to carboxy-terminal kinesins that contains a C-terminal domain responsible for the motor activity (it hydrolyzes ATP and binds microtubules)| PEPP (phosphoinositol 3-phosphate-binding protein) family PH (pleckstrin homology) domain-containing protein similar to PH domain region of vertebrate pleckstrin homology domain-containing family A member 4/5/6/7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAP_GLY pfam01302
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ...
 218-285 9.80e-34

CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


:

Pssm-ID: 460154 [Multi-domain]  Cd Length: 65  Bit Score: 124.44  E-value: 9.80e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442628156   218 VGDRVIVSsgfGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKV 285
Cdd:pfam01302    1 VGDRVEVP---GGRRGTVRYVGPVPFAPGVWVGVELDEPVGKNDGSVKGVRYFECPPKHGVFVRPSKV 65
CAP_GLY pfam01302
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ...
 104-168 6.35e-30

CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


:

Pssm-ID: 460154 [Multi-domain]  Cd Length: 65  Bit Score: 113.27  E-value: 6.35e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442628156   104 IGQRVWLGGTRPGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSRLTRL 168
Cdd:pfam01302    1 VGDRVEVPGGRRGTVRYVGPVPFAPGVWVGVELDEPVGKNDGSVKGVRYFECPPKHGVFVRPSKV 65
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 616-1469 2.53e-29

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 127.87  E-value: 2.53e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   616 LDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEklvrem 695
Cdd:TIGR02168  195 LNELERQLKSLERQAEKAERYKELKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEK------ 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   696 tenaINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQA 775
Cdd:TIGR02168  269 ----LEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEE 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   776 ALEELKKEKETI---IKEKEQELQQLQSKSAESESALkvvqvqleqlqqqaaasgEEGSKTVAKLHDEISQLKSQAEETQ 852
Cdd:TIGR02168  345 KLEELKEELESLeaeLEELEAELEELESRLEELEEQL------------------ETLRSKVAQLELQIASLNNEIERLE 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   853 SELKSTQSNLEAKSKQLEAANGSLEEEAKKSghLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEY 932
Cdd:TIGR02168  407 ARLERLEDRRERLQQEIEELLKKLEEAELKE--LQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAEREL 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   933 AESRA----------EASDLQDKVKE----------ITDTLHAELQAERSSSSALHTKLSKFSDEIATghkelTSKADAW 992
Cdd:TIGR02168  485 AQLQArldslerlqeNLEGFSEGVKAllknqsglsgILGVLSELISVDEGYEAAIEAALGGRLQAVVV-----ENLNAAK 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   993 SQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKE--KSFEESIKNLQEEVTKAKTeNLELSTGTQTTIKDLQERLEIT 1070
Cdd:TIGR02168  560 KAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKniEGFLGVAKDLVKFDPKLRK-ALSYLLGGVLVVDDLDNALELA 638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1071 NaELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELstvlevlqaeksetnhifelfemeadmnsERLIEKVTG 1150
Cdd:TIGR02168  639 K-KLRPGYRIVTLDGDLVRPGGVITGGSAKTNSSILERRREI-----------------------------EELEEKIEE 688

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1151 IKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSS 1230
Cdd:TIGR02168  689 LEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEE 768

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1231 IIEAQNTKLNESNVQLENKTSCLKETQDQ-------LLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVK 1303
Cdd:TIGR02168  769 RLEEAEEELAEAEAEIEELEAQIEQLKEElkalreaLDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIE 848

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1304 VLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESN 1383
Cdd:TIGR02168  849 ELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLE 928

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1384 TVLESQKKSHNEIQDKL--------EQAQQKERTLQEETSKLAEQLSQLKQ-----------ANEELQKSLQQKQLLLEK 1444
Cdd:TIGR02168  929 LRLEGLEVRIDNLQERLseeysltlEEAEALENKIEDDEEEARRRLKRLENkikelgpvnlaAIEEYEELKERYDFLTAQ 1008

                          890       900
                   ....*....|....*....|....*
gi 442628156  1445 GNEFDTQLAEYQKVIDEMDDAASVK 1469
Cdd:TIGR02168 1009 KEDLTEAKETLEEAIEEIDREARER 1033
NIP100 super family cl34954
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ...
 216-793 2.88e-11

Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG5244:

Pssm-ID: 227569 [Multi-domain]  Cd Length: 669  Bit Score: 68.56  E-value: 2.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  216 MAVGDRVIVSSGFGsrpgILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFV--------------- 280
Cdd:COG5244     4 LSVNDRVLLGDKFG----TVRFIGKTKFKDGIWIGLELDDPVGKNDGSVNGVRYFHCKKRHGIFIrpdddsllngnaaye 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  281 --------------PIAKVSLSPSSKKTRLSRTGSRESLTSIGTMNSIATTA---TSRMRMN------AQRKSSTPVKPI 337
Cdd:COG5244    80 kikgglvceskgmdKDGEIKQENHEDRIHFEESKIRRLEETIEALKSTEKEEiveLRRENEEldkinlSLRERISSEEPE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  338 LATPKSQFSMQDL--LREKQQHVEKLMVERDLDREDAQNQALQLQKNI--NELKARIVE--------LESALDNERKKTE 405
Cdd:COG5244   160 LNKDGSKLSYDELkeFVEESRVQVYDMVELVSDISETLNRNGSIQRSSvrECERSNIHDvlflvngiLDGVIDELNGELE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  406 ELQ---CSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLvsATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQkeV 482
Cdd:COG5244   240 RLRrqlVSLMSSHGIEVEENSRLKATLEKFQSLELKVNTL--QEELYQNKLLKKFYQIYEPFAQAALSSQLQYLAEV--I 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  483 ESRIAEQLEeeqrlrenvkylNEQIATLQSELVSKDEALEKFSLSECgiENLRRELELLKEENEKQAQEAQAEFTRKLAE 562
Cdd:COG5244   316 ESENFGKLE------------NIEIHIILKVLSSISYALHIYTIKNT--PDHLETTLQCFVNIAPISMWLSEFLQRKFSS 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  563 KSVEVLrlsSELQNLKATSDSLE----------------------SERVNKTDECEILQTEVRMRdeQIRELNQQlDEVT 620
Cdd:COG5244   382 KQETAF---SICQFLEDNKDVTLilkilhpilettvpkllaflrtNSNFNDNDTLCLIGSLYEIA--RIDKLIGK-EEIS 455

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  621 TQLN----VQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMT 696
Cdd:COG5244   456 KQDNrlflYPSCDITLSSILTILFSDKLEVFFQGIESLLENITIFPEQPSQQTSDSENIKENSLLSDRLNEENIRLKEVL 535

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  697 ENAINQIQLEKESieQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHE---KL 773
Cdd:COG5244   536 VQKENMLTEETKI--KIIIGRDLERKTLEENIKTLKVELNNKNNKLKEENFNLVNRLKNMELKLYQIKDNNTLNKiylDL 613

                         650       660
                  ....*....|....*....|
gi 442628156  774 QAALEELKKEKETIIKEKEQ 793
Cdd:COG5244   614 VSEIMELRETIRRQIKEQKR 633
CLIP1_ZNF pfam16641
CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of ...
 1646-1662 1.29e-06

CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of the cytoplasmic linker protein CLIP1 (CLIP170). It forms a complex with the CAP-Gly domain of Dynactin.


:

Pssm-ID: 465212  Cd Length: 17  Bit Score: 45.92  E-value: 1.29e-06
                           10
                   ....*....|....*..
gi 442628156  1646 RKYCDSCEVFGHDTSEC 1662
Cdd:pfam16641    1 RPYCEICEVFGHDTEDC 17
CLIP1_ZNF pfam16641
CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of ...
 1599-1616 9.42e-05

CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of the cytoplasmic linker protein CLIP1 (CLIP170). It forms a complex with the CAP-Gly domain of Dynactin.


:

Pssm-ID: 465212  Cd Length: 17  Bit Score: 40.91  E-value: 9.42e-05
                           10
                   ....*....|....*...
gi 442628156  1599 RLFCDICDEFDqHDTEDC 1616
Cdd:pfam16641    1 RPYCEICEVFG-HDTEDC 17
COG4913 super family cl25907
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1407-1576 4.56e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


The actual alignment was detected with superfamily member COG4913:

Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 4.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1407 ERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLL---EKGNEFDTQLAEYQkVIDEMDDAASV--KSALLEQLQNRVA 1481
Cdd:COG4913   220 EPDTFEAADALVEHFDDLERAHEALEDAREQIELLEpirELAERYAAARERLA-ELEYLRAALRLwfAQRRLELLEAELE 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1482 ELETALRQANDAQKtayletkELRRQLESLEleksREVLSLKAQMNGASsrsgkGDEVESLDietslAKINFLNSIIADM 1561
Cdd:COG4913   299 ELRAELARLEAELE-------RLEARLDALR----EELDELEAQIRGNG-----GDRLEQLE-----REIERLERELEER 357

                         170
                  ....*....|....*
gi 442628156 1562 QQKNDALKAKVQTLE 1576
Cdd:COG4913   358 ERRRARLEALLAALG 372
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 2-92 1.24e-03

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156    2 SDDTSASGGTSAPFPSPVTADPEPGATASKLPGPIRSNIPTPATSGTGIPqpskmkAPSSFGSTGSVSKIGRPCCNHTTP 81
Cdd:PHA03307  280 SRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSST------SSSSESSRGAAVSPGPSPSRSPSP 353

                          90
                  ....*....|.
gi 442628156   82 KSGPPPRDNSS 92
Cdd:PHA03307  354 SRPPPPADPSS 364
 
Name Accession Description Interval E-value
CAP_GLY pfam01302
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ...
 218-285 9.80e-34

CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


Pssm-ID: 460154 [Multi-domain]  Cd Length: 65  Bit Score: 124.44  E-value: 9.80e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442628156   218 VGDRVIVSsgfGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKV 285
Cdd:pfam01302    1 VGDRVEVP---GGRRGTVRYVGPVPFAPGVWVGVELDEPVGKNDGSVKGVRYFECPPKHGVFVRPSKV 65
CAP_GLY pfam01302
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ...
 104-168 6.35e-30

CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


Pssm-ID: 460154 [Multi-domain]  Cd Length: 65  Bit Score: 113.27  E-value: 6.35e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442628156   104 IGQRVWLGGTRPGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSRLTRL 168
Cdd:pfam01302    1 VGDRVEVPGGRRGTVRYVGPVPFAPGVWVGVELDEPVGKNDGSVKGVRYFECPPKHGVFVRPSKV 65
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 616-1469 2.53e-29

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 127.87  E-value: 2.53e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   616 LDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEklvrem 695
Cdd:TIGR02168  195 LNELERQLKSLERQAEKAERYKELKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEK------ 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   696 tenaINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQA 775
Cdd:TIGR02168  269 ----LEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEE 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   776 ALEELKKEKETI---IKEKEQELQQLQSKSAESESALkvvqvqleqlqqqaaasgEEGSKTVAKLHDEISQLKSQAEETQ 852
Cdd:TIGR02168  345 KLEELKEELESLeaeLEELEAELEELESRLEELEEQL------------------ETLRSKVAQLELQIASLNNEIERLE 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   853 SELKSTQSNLEAKSKQLEAANGSLEEEAKKSghLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEY 932
Cdd:TIGR02168  407 ARLERLEDRRERLQQEIEELLKKLEEAELKE--LQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAEREL 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   933 AESRA----------EASDLQDKVKE----------ITDTLHAELQAERSSSSALHTKLSKFSDEIATghkelTSKADAW 992
Cdd:TIGR02168  485 AQLQArldslerlqeNLEGFSEGVKAllknqsglsgILGVLSELISVDEGYEAAIEAALGGRLQAVVV-----ENLNAAK 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   993 SQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKE--KSFEESIKNLQEEVTKAKTeNLELSTGTQTTIKDLQERLEIT 1070
Cdd:TIGR02168  560 KAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKniEGFLGVAKDLVKFDPKLRK-ALSYLLGGVLVVDDLDNALELA 638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1071 NaELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELstvlevlqaeksetnhifelfemeadmnsERLIEKVTG 1150
Cdd:TIGR02168  639 K-KLRPGYRIVTLDGDLVRPGGVITGGSAKTNSSILERRREI-----------------------------EELEEKIEE 688

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1151 IKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSS 1230
Cdd:TIGR02168  689 LEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEE 768

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1231 IIEAQNTKLNESNVQLENKTSCLKETQDQ-------LLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVK 1303
Cdd:TIGR02168  769 RLEEAEEELAEAEAEIEELEAQIEQLKEElkalreaLDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIE 848

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1304 VLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESN 1383
Cdd:TIGR02168  849 ELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLE 928

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1384 TVLESQKKSHNEIQDKL--------EQAQQKERTLQEETSKLAEQLSQLKQ-----------ANEELQKSLQQKQLLLEK 1444
Cdd:TIGR02168  929 LRLEGLEVRIDNLQERLseeysltlEEAEALENKIEDDEEEARRRLKRLENkikelgpvnlaAIEEYEELKERYDFLTAQ 1008

                          890       900
                   ....*....|....*....|....*
gi 442628156  1445 GNEFDTQLAEYQKVIDEMDDAASVK 1469
Cdd:TIGR02168 1009 KEDLTEAKETLEEAIEEIDREARER 1033
CAP_GLY smart01052
Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and ...
 218-286 2.64e-29

Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network; A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


Pssm-ID: 214997 [Multi-domain]  Cd Length: 68  Bit Score: 111.91  E-value: 2.64e-29
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156    218 VGDRVIVSSGfgSRPGILRYLGETQFAPGNWCGVELDEP-SGKNDGTVDDIRYFECKPKYGVFVPIAKVS 286
Cdd:smart01052    1 VGDRVEVGGG--GRRGTVRYVGPTPFAPGVWVGVELDEPlRGKNDGSVKGVRYFECPPKHGIFVRPSKVE 68
CAP_GLY smart01052
Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and ...
 104-169 3.42e-23

Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network; A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


Pssm-ID: 214997 [Multi-domain]  Cd Length: 68  Bit Score: 94.19  E-value: 3.42e-23
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442628156    104 IGQRVWLGGT-RPGQIAFIGDTHFAAGEWAGVVLDEPN-GKNDGCVSGKRYFQCEPKRGIFSRLTRLT 169
Cdd:smart01052    1 VGDRVEVGGGgRRGTVRYVGPTPFAPGVWVGVELDEPLrGKNDGSVKGVRYFECPPKHGIFVRPSKVE 68
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1146-1497 3.63e-23

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 107.72  E-value: 3.63e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1146 EKVTGIKEELKETH-----LQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQN 1220
Cdd:COG1196   213 ERYRELKEELKELEaelllLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYE 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1221 LEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEE 1300
Cdd:COG1196   293 LLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEA 372

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1301 LVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLD 1380
Cdd:COG1196   373 ELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEA 452

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1381 ESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVID 1460
Cdd:COG1196   453 ELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGV 532

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 442628156 1461 EMDDAASVKSALLEQLQNRVAELETALRQANDAQKTA 1497
Cdd:COG1196   533 EAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAA 569
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 645-1518 6.53e-19

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 93.88  E-value: 6.53e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   645 EEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLA--EQEKLVREMTENAINQIQLEKESIEQQLALKQNELE 722
Cdd:pfam02463  186 AELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLylDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEE 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   723 DFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKeketiikeKEQELQQLQSKS 802
Cdd:pfam02463  266 KLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKK--------AEKELKKEKEEI 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   803 AESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKK 882
Cdd:pfam02463  338 EELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQL 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   883 SGHLLEQITKLKSEVGETQaalsschTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERS 962
Cdd:pfam02463  418 EDLLKEEKKEELEILEEEE-------ESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLL 490

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   963 SSSALHTKLSKFSDEIATGHKELTSKADawsqemlqkekelqelrqqlqdsqDSQTKLKAEGERKEKSFEESIKNLQEEV 1042
Cdd:pfam02463  491 SRQKLEERSQKESKARSGLKVLLALIKD------------------------GVGGRIISAHGRLGDLGVAVENYKVAIS 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1043 TKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAE 1122
Cdd:pfam02463  547 TAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVE 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1123 KSETNHIFELFEMEADMNSERLIEKVTGIKEElkethLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQ 1202
Cdd:pfam02463  627 GILKDTELTKLKESAKAKESGLRKGVSLEEGL-----AEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEI 701

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1203 SLQELqdsvKQKEELVQNLEEKVResssiIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQ 1282
Cdd:pfam02463  702 KKKEQ----REKEELKKLKLEAEE-----LLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLK 772

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1283 QVQEANGDIKDSLVKVEELvkvLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELK 1362
Cdd:pfam02463  773 EKELAEEREKTEKLKVEEE---KEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLE 849

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1363 EALCQKENGLKELQGKLDESNtvLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLL 1442
Cdd:pfam02463  850 KLAEEELERLEEEITKEELLQ--ELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEA 927

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442628156  1443 EKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSRE 1518
Cdd:pfam02463  928 EILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEE 1003
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
869-1491 1.75e-18

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 92.03  E-value: 1.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  869 LEAANGSLEE-----EAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEkvnkEYAESRAEASDLQ 943
Cdd:PRK02224  182 LSDQRGSLDQlkaqiEEKEEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLE----EHEERREELETLE 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  944 DKVKEITDTLhAELQAERSS-SSALHTK---LSKFSDEIA-----TGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQ 1014
Cdd:PRK02224  258 AEIEDLRETI-AETEREREElAEEVRDLrerLEELEEERDdllaeAGLDDADAEAVEARREELEDRDEELRDRLEECRVA 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1015 DSQTKLKAEGERkeksfeESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEitnaelqhkekmasedaqKIADLKTL 1094
Cdd:PRK02224  337 AQAHNEEAESLR------EDADDLEERAEELREEAAELESELEEAREAVEDRRE------------------EIEELEEE 392

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1095 VEAIQVANANISATNAELSTVLEVLQAEKSETNHifELFEMEADMNSER-LIEKVTGIKEELK----------ETHLQ-L 1162
Cdd:PRK02224  393 IEELRERFGDAPVDLGNAEDFLEELREERDELRE--REAELEATLRTAReRVEEAEALLEAGKcpecgqpvegSPHVEtI 470

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1163 DERQKKFEELEEKLKQAQqseqklqqESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNEs 1242
Cdd:PRK02224  471 EEDRERVEELEAELEDLE--------EEVEEVEERLERAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEE- 541

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1243 nvqlenktsclketqdqllesqkkekqLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQAt 1322
Cdd:PRK02224  542 ---------------------------LRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLER- 593

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1323 nkeLQELLVKSQENEGNLQgeslAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDEsntvlesqkkshneiqDKLEQ 1402
Cdd:PRK02224  594 ---IRTLLAAIADAEDEIE----RLREKREALAELNDERRERLAEKRERKRELEAEFDE----------------ARIEE 650

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1403 AQQKERTLQEETSKLAEQLSQLKQANEELQKSLqqkqlllekgNEFDTQLAEYQKVIDEMDDAASVKSAL------LEQL 1476
Cdd:PRK02224  651 AREDKERAEEYLEQVEEKLDELREERDDLQAEI----------GAVENELEELEELRERREALENRVEALealydeAEEL 720

                         650
                  ....*....|....*
gi 442628156 1477 QNRVAELETALRQAN 1491
Cdd:PRK02224  721 ESMYGDLRAELRQRN 735
NIP100 COG5244
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ...
 216-793 2.88e-11

Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227569 [Multi-domain]  Cd Length: 669  Bit Score: 68.56  E-value: 2.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  216 MAVGDRVIVSSGFGsrpgILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFV--------------- 280
Cdd:COG5244     4 LSVNDRVLLGDKFG----TVRFIGKTKFKDGIWIGLELDDPVGKNDGSVNGVRYFHCKKRHGIFIrpdddsllngnaaye 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  281 --------------PIAKVSLSPSSKKTRLSRTGSRESLTSIGTMNSIATTA---TSRMRMN------AQRKSSTPVKPI 337
Cdd:COG5244    80 kikgglvceskgmdKDGEIKQENHEDRIHFEESKIRRLEETIEALKSTEKEEiveLRRENEEldkinlSLRERISSEEPE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  338 LATPKSQFSMQDL--LREKQQHVEKLMVERDLDREDAQNQALQLQKNI--NELKARIVE--------LESALDNERKKTE 405
Cdd:COG5244   160 LNKDGSKLSYDELkeFVEESRVQVYDMVELVSDISETLNRNGSIQRSSvrECERSNIHDvlflvngiLDGVIDELNGELE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  406 ELQ---CSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLvsATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQkeV 482
Cdd:COG5244   240 RLRrqlVSLMSSHGIEVEENSRLKATLEKFQSLELKVNTL--QEELYQNKLLKKFYQIYEPFAQAALSSQLQYLAEV--I 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  483 ESRIAEQLEeeqrlrenvkylNEQIATLQSELVSKDEALEKFSLSECgiENLRRELELLKEENEKQAQEAQAEFTRKLAE 562
Cdd:COG5244   316 ESENFGKLE------------NIEIHIILKVLSSISYALHIYTIKNT--PDHLETTLQCFVNIAPISMWLSEFLQRKFSS 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  563 KSVEVLrlsSELQNLKATSDSLE----------------------SERVNKTDECEILQTEVRMRdeQIRELNQQlDEVT 620
Cdd:COG5244   382 KQETAF---SICQFLEDNKDVTLilkilhpilettvpkllaflrtNSNFNDNDTLCLIGSLYEIA--RIDKLIGK-EEIS 455

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  621 TQLN----VQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMT 696
Cdd:COG5244   456 KQDNrlflYPSCDITLSSILTILFSDKLEVFFQGIESLLENITIFPEQPSQQTSDSENIKENSLLSDRLNEENIRLKEVL 535

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  697 ENAINQIQLEKESieQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHE---KL 773
Cdd:COG5244   536 VQKENMLTEETKI--KIIIGRDLERKTLEENIKTLKVELNNKNNKLKEENFNLVNRLKNMELKLYQIKDNNTLNKiylDL 613

                         650       660
                  ....*....|....*....|
gi 442628156  774 QAALEELKKEKETIIKEKEQ 793
Cdd:COG5244   614 VSEIMELRETIRRQIKEQKR 633
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 362-783 1.88e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 66.23  E-value: 1.88e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   362 MVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHDLESKITK 441
Cdd:TIGR02168  672 ILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQ 751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   442 lvsatpslqsilppdlpsddgaLQEEIAKLQEKMTiqqkEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEAL 521
Cdd:TIGR02168  752 ----------------------LSKELTELEAEIE----ELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREAL 805

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   522 EKFS--LSECGIENLRRELELLKEENEKQAQEAQAEFTRK-LAEKSVEVLRLSSELQNLKATSDSLESERvnktdecEIL 598
Cdd:TIGR02168  806 DELRaeLTLLNEEAANLRERLESLERRIAATERRLEDLEEqIEELSEDIESLAAEIEELEELIEELESEL-------EAL 878

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   599 QTEVRMRDEQIRELNQQLDEVTTQLNvqkadsSALDDMLRLQKEgteekstlLEKTEKELVQSKEQAAKTLNDKEQLekq 678
Cdd:TIGR02168  879 LNERASLEEALALLRSELEELSEELR------ELESKRSELRRE--------LEELREKLAQLELRLEGLEVRIDNL--- 941

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   679 isdLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFqkkqseSEVHL---QEIKAQNTQKDFelvesges 755
Cdd:TIGR02168  942 ---QERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKEL------GPVNLaaiEEYEELKERYDF-------- 1004

                          410       420
                   ....*....|....*....|....*...
gi 442628156   756 lkkLQQQLEQKTLGHEKLQAALEELKKE 783
Cdd:TIGR02168 1005 ---LTAQKEDLTEAKETLEEAIEEIDRE 1029
NIP100 COG5244
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ...
 104-164 1.52e-08

Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227569 [Multi-domain]  Cd Length: 669  Bit Score: 59.70  E-value: 1.52e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442628156  104 IGQRVWLGGTRpGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSR 164
Cdd:COG5244     6 VNDRVLLGDKF-GTVRFIGKTKFKDGIWIGLELDDPVGKNDGSVNGVRYFHCKKRHGIFIR 65
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 465-748 4.67e-07

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 54.74  E-value: 4.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   465 QEEIAKLQEKMTIQQKevesRIAEQLEEEQRLRENVKYLNEQIATLqselVSKDEALEKFSLSECGIENLRRELELLKEE 544
Cdd:pfam17380  332 QAAIYAEQERMAMERE----RELERIRQEERKRELERIRQEEIAME----ISRMRELERLQMERQQKNERVRQELEAARK 403

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   545 NEKQAQEAQaeftRKLAEKSVEVLRLSSELQNLKATS-DSLESERVNktdECEILQTEVRMRDEQIRELNQQLDEvttql 623
Cdd:pfam17380  404 VKILEEERQ----RKIQQQKVEMEQIRAEQEEARQREvRRLEEERAR---EMERVRLEEQERQQQVERLRQQEEE----- 471

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   624 nvQKADSSALDDMLRLQKEGTEEKSTLLEKtekELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQI 703
Cdd:pfam17380  472 --RKRKKLELEKEKRDRKRAEEQRRKILEK---ELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQ 546

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 442628156   704 QL-EKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFE 748
Cdd:pfam17380  547 EMeERRRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAEYE 592
CLIP1_ZNF pfam16641
CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of ...
 1646-1662 1.29e-06

CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of the cytoplasmic linker protein CLIP1 (CLIP170). It forms a complex with the CAP-Gly domain of Dynactin.


Pssm-ID: 465212  Cd Length: 17  Bit Score: 45.92  E-value: 1.29e-06
                           10
                   ....*....|....*..
gi 442628156  1646 RKYCDSCEVFGHDTSEC 1662
Cdd:pfam16641    1 RPYCEICEVFGHDTEDC 17
PRK11281 PRK11281
mechanosensitive channel MscK;
392-802 2.34e-06

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 52.61  E-value: 2.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  392 ELESALD--NERKKTEE----LQCSIDEAQfcgdELNAQSQVYKEKIHDLESKITKlvsATPSLQSIlppdlpsddgalQ 465
Cdd:PRK11281   40 DVQAQLDalNKQKLLEAedklVQQDLEQTL----ALLDKIDRQKEETEQLKQQLAQ---APAKLRQA------------Q 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  466 EEIAKLQEKM---------TIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSelvskdealekfslsecgienlrr 536
Cdd:PRK11281  101 AELEALKDDNdeetretlsTLSLRQLESRLAQTLDQLQNAQNDLAEYNSQLVSLQT------------------------ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  537 elellkeenekQAQEAQAEftrkLAEKSVEVLRLSSELQNLKATSDSLESERVNKtdeceiLQTEVRMRDEQIrELNQQL 616
Cdd:PRK11281  157 -----------QPERAQAA----LYANSQRLQQIRNLLKGGKVGGKALRPSQRVL------LQAEQALLNAQN-DLQRKS 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  617 DEVTTQLNvqkadssaldDMLRLQKEGTEEKSTLLEKT---------EKELVQSKEQAAKTLNDKE------------QL 675
Cdd:PRK11281  215 LEGNTQLQ----------DLLQKQRDYLTARIQRLEHQlqllqeainSKRLTLSEKTVQEAQSQDEaariqanplvaqEL 284

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  676 E--KQISD--------LKQLAEQEKLVREMTENAINQIQLEKESI--------------EQQLALKQNEL-EDFQKKQSE 730
Cdd:PRK11281  285 EinLQLSQrllkatekLNTLTQQNLRVKNWLDRLTQSERNIKEQIsvlkgslllsrilyQQQQALPSADLiEGLADRIAD 364

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  731 SEVHLQEIkaqNTQKDfELVESGESLKKLQQQleQKTLGHEKLQAALEELKKEKETIIKEKEQEL--------------Q 796
Cdd:PRK11281  365 LRLEQFEI---NQQRD-ALFQPDAYIDKLEAG--HKSEVTDEVRDALLQLLDERRELLDQLNKQLnnqlnlainlqlnqQ 438


                  ....*.
gi 442628156  797 QLQSKS 802
Cdd:PRK11281  439 QLLSVS 444
CLIP1_ZNF pfam16641
CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of ...
 1599-1616 9.42e-05

CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of the cytoplasmic linker protein CLIP1 (CLIP170). It forms a complex with the CAP-Gly domain of Dynactin.


Pssm-ID: 465212  Cd Length: 17  Bit Score: 40.91  E-value: 9.42e-05
                           10
                   ....*....|....*...
gi 442628156  1599 RLFCDICDEFDqHDTEDC 1616
Cdd:pfam16641    1 RPYCEICEVFG-HDTEDC 17
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1407-1576 4.56e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 4.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1407 ERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLL---EKGNEFDTQLAEYQkVIDEMDDAASV--KSALLEQLQNRVA 1481
Cdd:COG4913   220 EPDTFEAADALVEHFDDLERAHEALEDAREQIELLEpirELAERYAAARERLA-ELEYLRAALRLwfAQRRLELLEAELE 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1482 ELETALRQANDAQKtayletkELRRQLESLEleksREVLSLKAQMNGASsrsgkGDEVESLDietslAKINFLNSIIADM 1561
Cdd:COG4913   299 ELRAELARLEAELE-------RLEARLDALR----EELDELEAQIRGNG-----GDRLEQLE-----REIERLERELEER 357

                         170
                  ....*....|....*
gi 442628156 1562 QQKNDALKAKVQTLE 1576
Cdd:COG4913   358 ERRRARLEALLAALG 372
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 609-989 7.69e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 44.23  E-value: 7.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  609 IRELNQQLDEVTTQLNVqkadsSALDDMLRLQKEGTEEKSTLLEKTEKELvqSKEQAAKTLNDKEQLEKQISDL-KQLAE 687
Cdd:NF033838   71 LSEIQKSLDKRKHTQNV-----ALNKKLSDIKTEYLYELNVLKEKSEAEL--TSKTKKELDAAFEQFKKDTLEPgKKVAE 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  688 QEKLVREMTENAINQIQlEKESIEQQLALKQNELE--DFQKKQSESEVHLQEIKAQNTQKDfelvesgESLKKLQQQLEQ 765
Cdd:NF033838  144 ATKKVEEAEKKAKDQKE-EDRRNYPTNTYKTLELEiaESDVEVKKAELELVKEEAKEPRDE-------EKIKQAKAKVES 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  766 KtlgheklQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLK 845
Cdd:NF033838  216 K-------KAEATRLEKIKTDREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDS 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  846 SQAEET--QSELKSTQSNLEAKSKQLEAangslEEEAKksghlleqitKLKSEVGETQAALSSCHTDVESKTKQLEAANA 923
Cdd:NF033838  289 SVGEETlpSPSLKPEKKVAEAEKKVEEA-----KKKAK----------DQKEEDRRNYPTNTYKTLELEIAESDVKVKEA 353

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442628156  924 ALEKVNKEYAESRAEasdlqDKVKEItdtlhaelQAERSSSSALHTKLSKFSDEIATGHKELTSKA 989
Cdd:NF033838  354 ELELVKEEAKEPRNE-----EKIKQA--------KAKVESKKAEATRLEKIKTDRKKAEEEAKRKA 406
ClyA-like cd21116
family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including ...
 1175-1323 8.55e-04

family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including Bacillus cereus HblB, Aeromonas hydrophila AhlB, Bacillus thuringiensis Cry6Aa and similar proteins; This family belongs to the ClyA family of alpha-PFT bacterial toxins. PFTs form the major group of virulence factors in many pathogenic bacteria and in general are critical components of the molecular offensive and defensive machinery of cells in all kingdoms of life. Bacterial PFTs facilitate the takeover of host resources by puncturing holes in the membrane. PFTs can be classified as alpha-PFTs and beta-PFTs depending on the secondary structures of their membrane component. Alpha-PFTs use a ring of amphipathic helices while beta-PFTs use a beta-barrel to construct the pore. Members of this family include the toxins: Bacillus cereus hemolysin binding component B (HblB or HBL-B) of the diarrheal enterotoxin hemolysin BL, Aeromonas hydrophila hemolytic (Ahl) component B (AhlB) of the tripartite AhlABC toxin, Vibrio cholerae cytotoxin motility associated killing factor A (MakA) cytotoxin, Xenorhabdus nematophila alpha-xenorhabdolysin (XaxA), Bacillus thuringiensis crystal 6Aa (Cry6Aa) parasporal crystal (Cry) toxin, and Bacillus cereus non-hemolytic enterotoxin (Nhe) component A (NheA) of the non-hemolytic enterotoxin Nhe, which, despite its name, is hemolytic, among others. In solution, ClyA proteins have an elongated, almost entirely alpha-helical structure, except for a short hydrophobic beta-hairpin known as the beta-tongue. Pore formation by ClyA requires circular oligomerization of the toxin by a sequential mechanism. This, in turn, concentrates the amphipathic helices in the center of the ring-like structure, forming a helical barrel that inserts into the membrane by a wedge-like mechanism. Compared with ClyA, NheA is almost entirely alpha-helical with an enlarged "head" domain, and an enlarged beta-tongue; it has been proposed that NheA could even form beta-barrel pores. Alpha-PFTs with similar structures are increasingly being found in eukaryotes, in particular as components of the immune systems of animals. This family may be distantly related to Escherichia coli alpha-PFT hemolysin E (HlyE, also known as ClyA or SheA).


Pssm-ID: 439149 [Multi-domain]  Cd Length: 224  Bit Score: 42.79  E-value: 8.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1175 KLKQAQQSEQKLQQESQTSKEKLteiQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLK 1254
Cdd:cd21116    74 YYPDLIELADNLIKGDQGAKQQL---LQGLEALQSQVTKKQTSVTSFINELTTFKNDLDDDSRNLQTDATKAQAQVAVLN 150

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442628156 1255 ETQDQLlesqkkeKQLQEEAAKLSGELQQVQEANGDIKDSLvkveelvKVLEEKLQAATSQLDAQQATN 1323
Cdd:cd21116   151 ALKNQL-------NSLAEQIDAAIDALEKLSNDWQTLDSDI-------KELITDLEDAESSIDAAFLQA 205
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2-92 1.24e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156    2 SDDTSASGGTSAPFPSPVTADPEPGATASKLPGPIRSNIPTPATSGTGIPqpskmkAPSSFGSTGSVSKIGRPCCNHTTP 81
Cdd:PHA03307  280 SRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSST------SSSSESSRGAAVSPGPSPSRSPSP 353

                          90
                  ....*....|.
gi 442628156   82 KSGPPPRDNSS 92
Cdd:PHA03307  354 SRPPPPADPSS 364
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 1199-1426 1.29e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 42.70  E-value: 1.29e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   1199 EIQQ-SLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQlLESQK-----KEKQLQE 1272
Cdd:smart00787   66 ELYQfSCKELKKYISEGRDLFKEIEEETLINNPPLFKEYFSASPDVKLLMDKQFQLVKTFAR-LEAKKmwyewRMKLLEG 144

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   1273 EAAKLSGELQQVQEAngdiKDSLVKVEELVKVLEEKLQaatsqlDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQ 1352
Cdd:smart00787  145 LKEGLDENLEGLKED----YKLLMKELELLNSIKPKLR------DRKDALEEELRQLKQLEDELEDCDPTELDRAKEKLK 214

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442628156   1353 QLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTlqeETSKLAEQLSQLKQ 1426
Cdd:smart00787  215 KLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFTFK---EIEKLKEQLKLLQS 285
 
Name Accession Description Interval E-value
CAP_GLY pfam01302
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ...
 218-285 9.80e-34

CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


Pssm-ID: 460154 [Multi-domain]  Cd Length: 65  Bit Score: 124.44  E-value: 9.80e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442628156   218 VGDRVIVSsgfGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKV 285
Cdd:pfam01302    1 VGDRVEVP---GGRRGTVRYVGPVPFAPGVWVGVELDEPVGKNDGSVKGVRYFECPPKHGVFVRPSKV 65
CAP_GLY pfam01302
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ...
 104-168 6.35e-30

CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


Pssm-ID: 460154 [Multi-domain]  Cd Length: 65  Bit Score: 113.27  E-value: 6.35e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442628156   104 IGQRVWLGGTRPGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSRLTRL 168
Cdd:pfam01302    1 VGDRVEVPGGRRGTVRYVGPVPFAPGVWVGVELDEPVGKNDGSVKGVRYFECPPKHGVFVRPSKV 65
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 616-1469 2.53e-29

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 127.87  E-value: 2.53e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   616 LDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEklvrem 695
Cdd:TIGR02168  195 LNELERQLKSLERQAEKAERYKELKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEK------ 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   696 tenaINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQA 775
Cdd:TIGR02168  269 ----LEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEE 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   776 ALEELKKEKETI---IKEKEQELQQLQSKSAESESALkvvqvqleqlqqqaaasgEEGSKTVAKLHDEISQLKSQAEETQ 852
Cdd:TIGR02168  345 KLEELKEELESLeaeLEELEAELEELESRLEELEEQL------------------ETLRSKVAQLELQIASLNNEIERLE 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   853 SELKSTQSNLEAKSKQLEAANGSLEEEAKKSghLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEY 932
Cdd:TIGR02168  407 ARLERLEDRRERLQQEIEELLKKLEEAELKE--LQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAEREL 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   933 AESRA----------EASDLQDKVKE----------ITDTLHAELQAERSSSSALHTKLSKFSDEIATghkelTSKADAW 992
Cdd:TIGR02168  485 AQLQArldslerlqeNLEGFSEGVKAllknqsglsgILGVLSELISVDEGYEAAIEAALGGRLQAVVV-----ENLNAAK 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   993 SQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKE--KSFEESIKNLQEEVTKAKTeNLELSTGTQTTIKDLQERLEIT 1070
Cdd:TIGR02168  560 KAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKniEGFLGVAKDLVKFDPKLRK-ALSYLLGGVLVVDDLDNALELA 638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1071 NaELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELstvlevlqaeksetnhifelfemeadmnsERLIEKVTG 1150
Cdd:TIGR02168  639 K-KLRPGYRIVTLDGDLVRPGGVITGGSAKTNSSILERRREI-----------------------------EELEEKIEE 688

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1151 IKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSS 1230
Cdd:TIGR02168  689 LEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEE 768

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1231 IIEAQNTKLNESNVQLENKTSCLKETQDQ-------LLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVK 1303
Cdd:TIGR02168  769 RLEEAEEELAEAEAEIEELEAQIEQLKEElkalreaLDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIE 848

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1304 VLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESN 1383
Cdd:TIGR02168  849 ELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLE 928

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1384 TVLESQKKSHNEIQDKL--------EQAQQKERTLQEETSKLAEQLSQLKQ-----------ANEELQKSLQQKQLLLEK 1444
Cdd:TIGR02168  929 LRLEGLEVRIDNLQERLseeysltlEEAEALENKIEDDEEEARRRLKRLENkikelgpvnlaAIEEYEELKERYDFLTAQ 1008

                          890       900
                   ....*....|....*....|....*
gi 442628156  1445 GNEFDTQLAEYQKVIDEMDDAASVK 1469
Cdd:TIGR02168 1009 KEDLTEAKETLEEAIEEIDREARER 1033
CAP_GLY smart01052
Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and ...
 218-286 2.64e-29

Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network; A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


Pssm-ID: 214997 [Multi-domain]  Cd Length: 68  Bit Score: 111.91  E-value: 2.64e-29
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156    218 VGDRVIVSSGfgSRPGILRYLGETQFAPGNWCGVELDEP-SGKNDGTVDDIRYFECKPKYGVFVPIAKVS 286
Cdd:smart01052    1 VGDRVEVGGG--GRRGTVRYVGPTPFAPGVWVGVELDEPlRGKNDGSVKGVRYFECPPKHGIFVRPSKVE 68
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 607-1408 5.35e-26

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 117.09  E-value: 5.35e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   607 EQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKE----QLEKQISDL 682
Cdd:TIGR02169  184 ENIERLDLIIDEKRQQLERLRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLEeeleKLTEEISEL 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   683 KQ--------LAEQEKLVREMTENAINQIQ-------LEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQntqkdf 747
Cdd:TIGR02169  264 EKrleeieqlLEELNKKIKDLGEEEQLRVKekigeleAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAE------ 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   748 elvesgesLKKLQQQLEQKTLGHEKLQAALEELKKEKETIikekEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASG 827
Cdd:TIGR02169  338 --------IEELEREIEEERKRRDKLTEEYAELKEELEDL----RAELEEVDKEFAETRDELKDYREKLEKLKREINELK 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   828 EEGSK---TVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAAL 904
Cdd:TIGR02169  406 RELDRlqeELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKEL 485

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   905 SSchtdvesKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALhtklskfsdEIATGH-- 982
Cdd:TIGR02169  486 SK-------LQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAI---------EVAAGNrl 549

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   983 KELTSKADAWSQEMLQKEKELQELRQ------QLQDSQDSQTKLKAEG------------ERKEKSFE---------ESI 1035
Cdd:TIGR02169  550 NNVVVEDDAVAKEAIELLKRRKAGRAtflplnKMRDERRDLSILSEDGvigfavdlvefdPKYEPAFKyvfgdtlvvEDI 629

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1036 KNLQEEVTKAKTENLE---------------LSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQV 1100
Cdd:TIGR02169  630 EAARRLMGKYRMVTLEgelfeksgamtggsrAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQ 709

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1101 ANANISATNAELSTVLEVLQAEKSETNHIFElfEMEADMNSerLIEKVTGIKEELKETHLQLDERQKKFEELEEKL---- 1176
Cdd:TIGR02169  710 ELSDASRKIGEIEKEIEQLEQEEEKLKERLE--ELEEDLSS--LEQEIENVKSELKELEARIEELEEDLHKLEEALndle 785

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1177 --------KQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLEN 1248
Cdd:TIGR02169  786 arlshsriPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEE 865

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1249 KTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQE 1328
Cdd:TIGR02169  866 LEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEE 945

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1329 lLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDesntVLESQKKshnEIQDKLEQAQQKER 1408
Cdd:TIGR02169  946 -IPEEELSLEDVQAELQRVEEEIRALEPVNMLAIQEYEEVLKRLDELKEKRA----KLEEERK---AILERIEEYEKKKR 1017
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 726-1520 2.67e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 111.30  E-value: 2.67e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   726 KKQSESEVHLQEIKAQNTQKDFELveSGESLKKLQQQLEQKtlghEKLQAALEELKKEKETIIKEKEQELQQLQSKSAES 805
Cdd:TIGR02168  206 ERQAEKAERYKELKAELRELELAL--LVLRLEELREELEEL----QEELKEAEEELEELTAELQELEEKLEELRLEVSEL 279

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   806 ESALKVVQVQLEQLqqqaaasgeegSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGH 885
Cdd:TIGR02168  280 EEEIEELQKELYAL-----------ANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEE 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   886 LLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLhAELQAERSS-- 963
Cdd:TIGR02168  349 LKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRR-ERLQQEIEEll 427

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   964 SSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKE--KSFEESIKNLQEE 1041
Cdd:TIGR02168  428 KKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDslERLQENLEGFSEG 507

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1042 VTKAKTENLELSTGTQTtikdLQERLEITNAELQHKEKMASEDAQKIadlktLVEAIQVANANISA---TNAELSTVLE- 1117
Cdd:TIGR02168  508 VKALLKNQSGLSGILGV----LSELISVDEGYEAAIEAALGGRLQAV-----VVENLNAAKKAIAFlkqNELGRVTFLPl 578

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1118 -VLQAEKSETNHIFELFEMEADMNSERLIEK------------------VTGIKEEL----------------------- 1155
Cdd:TIGR02168  579 dSIKGTEIQGNDREILKNIEGFLGVAKDLVKfdpklrkalsyllggvlvVDDLDNALelakklrpgyrivtldgdlvrpg 658

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1156 -------KETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRES 1228
Cdd:TIGR02168  659 gvitggsAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARL 738

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1229 SSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEK 1308
Cdd:TIGR02168  739 EAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEE 818

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1309 LQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEAlcqkengLKELQGKLDESNTVLES 1388
Cdd:TIGR02168  819 AANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESE-------LEALLNERASLEEALAL 891

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1389 QKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQkqlLLEKGNEfdtqlaEYQKVIDEMDDAASV 1468
Cdd:TIGR02168  892 LRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN---LQERLSE------EYSLTLEEAEALENK 962

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 442628156  1469 KSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLE-----LEKSREVL 1520
Cdd:TIGR02168  963 IEDDEEEARRRLKRLENKIKELGPVNLAAIEEYEELKERYDFLTaqkedLTEAKETL 1019
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 478-1437 4.79e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 110.53  E-value: 4.79e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   478 QQKEVESRIAEQLEEEQRLRENVKYLNEQIATL--QSELVSK----DEALEKFSLSECGIE-NLRRELELLKEENEKQAQ 550
Cdd:TIGR02168  173 RRKETERKLERTRENLDRLEDILNELERQLKSLerQAEKAERykelKAELRELELALLVLRlEELREELEELQEELKEAE 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   551 EAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLnvQKADS 630
Cdd:TIGR02168  253 EELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQL--EELES 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   631 SALDDMLRLQKEGTEekstlLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKlvremteNAINQIQLEKESI 710
Cdd:TIGR02168  331 KLDELAEELAELEEK-----LEELKEELESLEAELEELEAELEELESRLEELEEQLETLR-------SKVAQLELQIASL 398

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   711 eqqlalkQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESgeSLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKE 790
Cdd:TIGR02168  399 -------NNEIERLEARLERLEDRRERLQQEIEELLKKLEEA--ELKELQAELEELEEELEELQEELERLEEALEELREE 469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   791 KEQELQQLQsksaesesalkvvqvqleqlqqqaaasgeegsktvaklhdeisQLKSQAEETQSELKSTQSNLEAKSKQLE 870
Cdd:TIGR02168  470 LEEAEQALD-------------------------------------------AAERELAQLQARLDSLERLQENLEGFSE 506

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   871 AANGSLEEEAKKSGHLLEQITKLKSEVGETQA---ALSSCHTDVESKTkqLEAANAALekvnkeyaESRAEASDLQDKVK 947
Cdd:TIGR02168  507 GVKALLKNQSGLSGILGVLSELISVDEGYEAAieaALGGRLQAVVVEN--LNAAKKAI--------AFLKQNELGRVTFL 576

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   948 EITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEkELQElrqqlqdsqdsqtklkAEGERK 1027
Cdd:TIGR02168  577 PLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVD-DLDN----------------ALELAK 639

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1028 EKSFEESIKNLQEE-------VTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQV 1100
Cdd:TIGR02168  640 KLRPGYRIVTLDGDlvrpggvITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRK 719

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1101 ANANISATNAELSTVLEVLQAEksetnhifelfemeadmnSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQ 1180
Cdd:TIGR02168  720 ELEELSRQISALRKDLARLEAE------------------VEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAE 781

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1181 QSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQL 1260
Cdd:TIGR02168  782 AEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEI 861

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1261 LESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNL 1340
Cdd:TIGR02168  862 EELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNL 941

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1341 QG---ESLAVTEKLQQLEQANGELKEALCQKEngLKELQGKLDESNTV-------LESQKKSHNEIQDKLEQAQQKERTL 1410
Cdd:TIGR02168  942 QErlsEEYSLTLEEAEALENKIEDDEEEARRR--LKRLENKIKELGPVnlaaieeYEELKERYDFLTAQKEDLTEAKETL 1019

                          970       980
                   ....*....|....*....|....*...
gi 442628156  1411 QEETSKL-AEQLSQLKQANEELQKSLQQ 1437
Cdd:TIGR02168 1020 EEAIEEIdREARERFKDTFDQVNENFQR 1047
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 673-1520 1.41e-23

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 109.00  E-value: 1.41e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   673 EQLEKQISDLKQLAEQEKLVREMTENAINQiqLEKESIEQQLALKQNELEDfQKKQSESEVHLQEIKAQNTQK---DFEL 749
Cdd:TIGR02169  170 RKKEKALEELEEVEENIERLDLIIDEKRQQ--LERLRREREKAERYQALLK-EKREYEGYELLKEKEALERQKeaiERQL 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   750 VESGESLKKLQQQLEQKTLGHEKLQAALEELKKEketIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEE 829
Cdd:TIGR02169  247 ASLEEELEKLTEEISELEKRLEEIEQLLEELNKK---IKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEER 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   830 GSKTVAKLHD---EISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLL-------EQITKLKSEVGE 899
Cdd:TIGR02169  324 LAKLEAEIDKllaEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRdelkdyrEKLEKLKREINE 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   900 TQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEIT---DTLHAELQAERSSSSALHTKLSKFSD 976
Cdd:TIGR02169  404 LKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEwklEQLAADLSKYEQELYDLKEEYDRVEK 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   977 EIATGHKELTSK---ADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKN-LQ------EEVTKAK 1046
Cdd:TIGR02169  484 ELSKLQRELAEAeaqARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEVAAGNrLNnvvvedDAVAKEA 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1047 TENLELSTGTQTTIkdlqerLEITNAELQHKEKMASEDAQKIADLKTLVE-AIQVANANISATNAELstVLEVLQAEKsE 1125
Cdd:TIGR02169  564 IELLKRRKAGRATF------LPLNKMRDERRDLSILSEDGVIGFAVDLVEfDPKYEPAFKYVFGDTL--VVEDIEAAR-R 634

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1126 TNHIFELFEMEADmnserLIEK---VTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQ 1202
Cdd:TIGR02169  635 LMGKYRMVTLEGE-----LFEKsgaMTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQ 709

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1203 SLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGEL- 1281
Cdd:TIGR02169  710 ELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLs 789

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1282 -QQVQEangdIKDSLVKVEELVKVLEEKLQaatsqlDAQQATNKELQELLVKSQENEgNLQGESLAVTEKLQQLEQANGE 1360
Cdd:TIGR02169  790 hSRIPE----IQAELSKLEEEVSRIEARLR------EIEQKLNRLTLEKEYLEKEIQ-ELQEQRIDLKEQIKSIEKEIEN 858

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1361 LKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKslqqkql 1440
Cdd:TIGR02169  859 LNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEE------- 931

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1441 llekgnefdtQLAEYQKVIDEMDDaASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLesLELEKSREVL 1520
Cdd:TIGR02169  932 ----------ELSEIEDPKGEDEE-IPEEELSLEDVQAELQRVEEEIRALEPVNMLAIQEYEEVLKRL--DELKEKRAKL 998
CAP_GLY smart01052
Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and ...
 104-169 3.42e-23

Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network; A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.


Pssm-ID: 214997 [Multi-domain]  Cd Length: 68  Bit Score: 94.19  E-value: 3.42e-23
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442628156    104 IGQRVWLGGT-RPGQIAFIGDTHFAAGEWAGVVLDEPN-GKNDGCVSGKRYFQCEPKRGIFSRLTRLT 169
Cdd:smart01052    1 VGDRVEVGGGgRRGTVRYVGPTPFAPGVWVGVELDEPLrGKNDGSVKGVRYFECPPKHGIFVRPSKVE 68
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1146-1497 3.63e-23

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 107.72  E-value: 3.63e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1146 EKVTGIKEELKETH-----LQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQN 1220
Cdd:COG1196   213 ERYRELKEELKELEaelllLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYE 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1221 LEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEE 1300
Cdd:COG1196   293 LLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEA 372

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1301 LVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLD 1380
Cdd:COG1196   373 ELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEA 452

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1381 ESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVID 1460
Cdd:COG1196   453 ELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGV 532

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 442628156 1461 EMDDAASVKSALLEQLQNRVAELETALRQANDAQKTA 1497
Cdd:COG1196   533 EAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAA 569
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 351-1068 3.41e-22

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 104.75  E-value: 3.41e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   351 LREKQQHVEKL-MVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQfcgDELNAQSQvyk 429
Cdd:TIGR02168  222 LRELELALLVLrLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQ---KELYALAN--- 295

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   430 eKIHDLESKITKLVSATPSLQsilppdlpSDDGALQEEIAKLQEKMTIQQKE---VESRIAEQLEEEQRLRENVKYLNEQ 506
Cdd:TIGR02168  296 -EISRLEQQKQILRERLANLE--------RQLEELEAQLEELESKLDELAEElaeLEEKLEELKEELESLEAELEELEAE 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   507 IATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSS-ELQNLKATSDSLE 585
Cdd:TIGR02168  367 LEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEaELKELQAELEELE 446

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   586 SERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEK--------- 656
Cdd:TIGR02168  447 EELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGlsgilgvls 526

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   657 ELVQSKEQAAKTL-------------NDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELED 723
Cdd:TIGR02168  527 ELISVDEGYEAAIeaalggrlqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKD 606

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   724 FQKKQSESEVHLQEI-----------KAQNTQK-----------DFELVESG------------------ESLKKLQQQL 763
Cdd:TIGR02168  607 LVKFDPKLRKALSYLlggvlvvddldNALELAKklrpgyrivtlDGDLVRPGgvitggsaktnssilerrREIEELEEKI 686

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   764 EQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESeSALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQ 843
Cdd:TIGR02168  687 EELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQI-SALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEE 765

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   844 LKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANA 923
Cdd:TIGR02168  766 LEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEE 845

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   924 ALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSdeiatghkELTSKADAWSQEMLQKEKEL 1003
Cdd:TIGR02168  846 QIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELE--------ELSEELRELESKRSELRREL 917

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442628156  1004 QELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLE 1068
Cdd:TIGR02168  918 EELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIK 982
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 841-1484 1.84e-21

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 101.94  E-value: 1.84e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  841 ISQLKSQAEETQSELKSTQSNLE-------AKSKQLEaangSLEEEAKKsghlLEQITKLKSEVGETQAALS-----SCH 908
Cdd:COG1196   167 ISKYKERKEEAERKLEATEENLErledilgELERQLE----PLERQAEK----AERYRELKEELKELEAELLllklrELE 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  909 TDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALhtklskfsDEIATGHKELTSK 988
Cdd:COG1196   239 AELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAEL--------ARLEQDIARLEER 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  989 ADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLE 1068
Cdd:COG1196   311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLE 390

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1069 ITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSEtnhifELFEMEADMNSERLIEKV 1148
Cdd:COG1196   391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEA-----AEEEAELEEEEEALLELL 465

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1149 TGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVkqkEELVQNLEEKVRES 1228
Cdd:COG1196   466 AELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAV---LIGVEAAYEAALEA 542

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1229 SSIIEAQNtKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEK 1308
Cdd:COG1196   543 ALAAALQN-IVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDT 621

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1309 LQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDEsntvles 1388
Cdd:COG1196   622 LLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELE------- 694

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1389 qkkshnEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEkgnEFDTQLAEYQKVIDEMDDAASV 1468
Cdd:COG1196   695 ------LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLE---EEELLEEEALEELPEPPDLEEL 765

                         650
                  ....*....|....*.
gi 442628156 1469 KSAlLEQLQNRVAELE 1484
Cdd:COG1196   766 ERE-LERLEREIEALG 780
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 369-1207 2.22e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 102.06  E-value: 2.22e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   369 REDAQNQALQLQKNINELKARIVELESALDN---------------ERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIH 433
Cdd:TIGR02168  174 RKETERKLERTRENLDRLEDILNELERQLKSlerqaekaerykelkAELRELELALLVLRLEELREELEELQEELKEAEE 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   434 DLESKITKLVSATPSLQsilppDLPSDDGALQEEIAKLQEKM---TIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATL 510
Cdd:TIGR02168  254 ELEELTAELQELEEKLE-----ELRLEVSELEEEIEELQKELyalANEISRLEQQKQILRERLANLERQLEELEAQLEEL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   511 QSelvSKDEALEKFSLSECGIEnLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVN 590
Cdd:TIGR02168  329 ES---KLDELAEELAELEEKLE-ELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIER 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   591 KTDECEILQTEVRMRDEQIRELNQQLDEvtTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLN 670
Cdd:TIGR02168  405 LEARLERLEDRRERLQQEIEELLKKLEE--AELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAER 482

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   671 DKEQLEKQISDLKQLAEQEklvrEMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQE------------- 737
Cdd:TIGR02168  483 ELAQLQARLDSLERLQENL----EGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAALGGrlqavvvenlnaa 558

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   738 IKAQNTQKDFE------LVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKE------------TIIKEKEQELQQLQ 799
Cdd:TIGR02168  559 KKAIAFLKQNElgrvtfLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPklrkalsyllggVLVVDDLDNALELA 638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   800 SKSAESESALKVVQVQLEQLQQQAAASGEEGSKTV------AKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAAN 873
Cdd:TIGR02168  639 KKLRPGYRIVTLDGDLVRPGGVITGGSAKTNSSILerrreiEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLR 718

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   874 GSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDtl 953
Cdd:TIGR02168  719 KELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKE-- 796

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   954 haELQAERSSSSALHTKLSKFSDEIAtghkELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEE 1033
Cdd:TIGR02168  797 --ELKALREALDELRAELTLLNEEAA----NLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEE 870

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1034 SIKNLqEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISAT-NAEL 1112
Cdd:TIGR02168  871 LESEL-EALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERlSEEY 949

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1113 STVLEVLQAEKSETnhifELFEMEADMNSERLIEKVTGIK-------EELKETHLQLDERQKKFEELEEKLKQAQQSEQK 1185
Cdd:TIGR02168  950 SLTLEEAEALENKI----EDDEEEARRRLKRLENKIKELGpvnlaaiEEYEELKERYDFLTAQKEDLTEAKETLEEAIEE 1025

                          890       900
                   ....*....|....*....|...
gi 442628156  1186 LQQE-SQTSKEKLTEIQQSLQEL 1207
Cdd:TIGR02168 1026 IDREaRERFKDTFDQVNENFQRV 1048
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 608-1188 8.30e-21

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 100.01  E-value: 8.30e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  608 QIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAE 687
Cdd:COG1196   233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRR 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  688 QEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKT 767
Cdd:COG1196   313 ELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEAL 392

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  768 LGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQ 847
Cdd:COG1196   393 RAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEA 472

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  848 AEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVEskTKQLEAANAALEK 927
Cdd:COG1196   473 ALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYE--AALEAALAAALQN 550

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  928 VNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQkekELQELR 1007
Cdd:COG1196   551 IVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDT---LLGRTL 627

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1008 QQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVT-KAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQ 1086
Cdd:COG1196   628 VAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTgGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEER 707

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1087 KIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEKVTGIKEELKEthL------ 1160
Cdd:COG1196   708 ELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEA--Lgpvnll 785

                         570       580       590
                  ....*....|....*....|....*....|.
gi 442628156 1161 ---QLDERQKKFEELEEKLKQAQQSEQKLQQ 1188
Cdd:COG1196   786 aieEYEELEERYDFLSEQREDLEEARETLEE 816
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1170-1494 1.57e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 95.77  E-value: 1.57e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1170 EELEEKLKQ-AQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVREsssiIEAQNTKLNESNVQLEN 1248
Cdd:COG1196   196 GELERQLEPlERQAEKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAE----LEELEAELAELEAELEE 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1249 KTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQE 1328
Cdd:COG1196   272 LRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEE 351

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1329 LLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKER 1408
Cdd:COG1196   352 ELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALA 431

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1409 TLQEETSKLAEQLSQLKQANEELQ-KSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETAL 1487
Cdd:COG1196   432 ELEEEEEEEEEALEEAAEEEAELEeEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVK 511


                  ....*..
gi 442628156 1488 RQANDAQ 1494
Cdd:COG1196   512 AALLLAG 518
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 645-1518 6.53e-19

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 93.88  E-value: 6.53e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   645 EEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLA--EQEKLVREMTENAINQIQLEKESIEQQLALKQNELE 722
Cdd:pfam02463  186 AELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLylDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEE 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   723 DFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKeketiikeKEQELQQLQSKS 802
Cdd:pfam02463  266 KLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKK--------AEKELKKEKEEI 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   803 AESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKK 882
Cdd:pfam02463  338 EELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQL 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   883 SGHLLEQITKLKSEVGETQaalsschTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERS 962
Cdd:pfam02463  418 EDLLKEEKKEELEILEEEE-------ESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLL 490

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   963 SSSALHTKLSKFSDEIATGHKELTSKADawsqemlqkekelqelrqqlqdsqDSQTKLKAEGERKEKSFEESIKNLQEEV 1042
Cdd:pfam02463  491 SRQKLEERSQKESKARSGLKVLLALIKD------------------------GVGGRIISAHGRLGDLGVAVENYKVAIS 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1043 TKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAE 1122
Cdd:pfam02463  547 TAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVE 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1123 KSETNHIFELFEMEADMNSERLIEKVTGIKEElkethLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQ 1202
Cdd:pfam02463  627 GILKDTELTKLKESAKAKESGLRKGVSLEEGL-----AEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEI 701

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1203 SLQELqdsvKQKEELVQNLEEKVResssiIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQ 1282
Cdd:pfam02463  702 KKKEQ----REKEELKKLKLEAEE-----LLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLK 772

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1283 QVQEANGDIKDSLVKVEELvkvLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELK 1362
Cdd:pfam02463  773 EKELAEEREKTEKLKVEEE---KEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLE 849

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1363 EALCQKENGLKELQGKLDESNtvLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLL 1442
Cdd:pfam02463  850 KLAEEELERLEEEITKEELLQ--ELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEA 927

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442628156  1443 EKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSRE 1518
Cdd:pfam02463  928 EILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEE 1003
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 348-1007 8.90e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 93.58  E-value: 8.90e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   348 QDLLREKQQHVEKLmverdldrEDAQNQALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQV 427
Cdd:TIGR02168  298 SRLEQQKQILRERL--------ANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEE 369

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   428 YKEKIHDLESKITKLVSATPSLQSILppdlpsddGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRENvkylneQI 507
Cdd:TIGR02168  370 LESRLEELEEQLETLRSKVAQLELQI--------ASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEA------EL 435

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   508 ATLQSELVSKDEALEKfslsecgienlrrelellKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESE 587
Cdd:TIGR02168  436 KELQAELEELEEELEE------------------LQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERL 497

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   588 RVNKtdecEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDML--RLQK------------------------ 641
Cdd:TIGR02168  498 QENL----EGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAALggRLQAvvvenlnaakkaiaflkqnelgrv 573

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   642 ---EGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEK----------- 707
Cdd:TIGR02168  574 tflPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALELAKKLRpgyrivtldgd 653

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   708 ------------ESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQA 775
Cdd:TIGR02168  654 lvrpggvitggsAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRK 733

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   776 ALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEgSKTVAKLHDEISQLKSQAEETQSEL 855
Cdd:TIGR02168  734 DLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEEL-EAQIEQLKEELKALREALDELRAEL 812

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   856 KST-------QSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKV 928
Cdd:TIGR02168  813 TLLneeaanlRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALL 892

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   929 NKEYAESRAEASDLQDKVKEitdtLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSK----ADAWSQEMLQKEKELQ 1004
Cdd:TIGR02168  893 RSELEELSEELRELESKRSE----LRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEysltLEEAEALENKIEDDEE 968


                   ...
gi 442628156  1005 ELR 1007
Cdd:TIGR02168  969 EAR 971
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
869-1491 1.75e-18

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 92.03  E-value: 1.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  869 LEAANGSLEE-----EAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEkvnkEYAESRAEASDLQ 943
Cdd:PRK02224  182 LSDQRGSLDQlkaqiEEKEEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLE----EHEERREELETLE 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  944 DKVKEITDTLhAELQAERSS-SSALHTK---LSKFSDEIA-----TGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQ 1014
Cdd:PRK02224  258 AEIEDLRETI-AETEREREElAEEVRDLrerLEELEEERDdllaeAGLDDADAEAVEARREELEDRDEELRDRLEECRVA 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1015 DSQTKLKAEGERkeksfeESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEitnaelqhkekmasedaqKIADLKTL 1094
Cdd:PRK02224  337 AQAHNEEAESLR------EDADDLEERAEELREEAAELESELEEAREAVEDRRE------------------EIEELEEE 392

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1095 VEAIQVANANISATNAELSTVLEVLQAEKSETNHifELFEMEADMNSER-LIEKVTGIKEELK----------ETHLQ-L 1162
Cdd:PRK02224  393 IEELRERFGDAPVDLGNAEDFLEELREERDELRE--REAELEATLRTAReRVEEAEALLEAGKcpecgqpvegSPHVEtI 470

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1163 DERQKKFEELEEKLKQAQqseqklqqESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNEs 1242
Cdd:PRK02224  471 EEDRERVEELEAELEDLE--------EEVEEVEERLERAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEE- 541

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1243 nvqlenktsclketqdqllesqkkekqLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQAt 1322
Cdd:PRK02224  542 ---------------------------LRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLER- 593

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1323 nkeLQELLVKSQENEGNLQgeslAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDEsntvlesqkkshneiqDKLEQ 1402
Cdd:PRK02224  594 ---IRTLLAAIADAEDEIE----RLREKREALAELNDERRERLAEKRERKRELEAEFDE----------------ARIEE 650

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1403 AQQKERTLQEETSKLAEQLSQLKQANEELQKSLqqkqlllekgNEFDTQLAEYQKVIDEMDDAASVKSAL------LEQL 1476
Cdd:PRK02224  651 AREDKERAEEYLEQVEEKLDELREERDDLQAEI----------GAVENELEELEELRERREALENRVEALealydeAEEL 720

                         650
                  ....*....|....*
gi 442628156 1477 QNRVAELETALRQAN 1491
Cdd:PRK02224  721 ESMYGDLRAELRQRN 735
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 570-1306 6.21e-18

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 90.08  E-value: 6.21e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   570 LSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKST 649
Cdd:TIGR04523   45 IKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKNKLEV 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   650 LLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQS 729
Cdd:TIGR04523  125 ELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLS 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   730 ESEVHLQEIKAQNTQkdfeLVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESAL 809
Cdd:TIGR04523  205 NLKKKIQKNKSLESQ----ISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNN 280

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   810 KVVqvqleqlqqqaaasgEEGSKTVAKLHDEISQLKSQAEetQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQ 889
Cdd:TIGR04523  281 KKI---------------KELEKQLNQLKSEISDLNNQKE--QDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQ 343

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   890 ITKLKSEVGETQaalsschTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQdkvkeitdtlhaelqaerSSSSALHT 969
Cdd:TIGR04523  344 ISQLKKELTNSE-------SENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLE------------------SQINDLES 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   970 KLSKFSDEiatgHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTEN 1049
Cdd:TIGR04523  399 KIQNQEKL----NQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLS 474

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1050 LElstgtqttIKDLQERLEITNAELQHKEKMASEDAQKIADLKtlvEAIQVANANISatnaELSTVLEVLQAEKSETNHI 1129
Cdd:TIGR04523  475 RS--------INKIKQNLEQKQKELKSKEKELKKLNEEKKELE---EKVKDLTKKIS----SLKEKIEKLESEKKEKESK 539

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1130 F-----ELFEMEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSL 1204
Cdd:TIGR04523  540 IsdledELNKDDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKEL 619

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1205 QELQDSVKQKEELVQNLE---EKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQD---QLLESQKKEKQLQEEAAKLS 1278
Cdd:TIGR04523  620 EKAKKENEKLSSIIKNIKskkNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKIDdiiELMKDWLKELSLHYKKYITR 699

                          730       740       750
                   ....*....|....*....|....*....|..
gi 442628156  1279 ----GELQQVQEANGDIKDSLVKVEELVKVLE 1306
Cdd:TIGR04523  700 miriKDLPKLEEKYKEIEKELKKLDEFSKELE 731
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 481-1421 8.38e-18

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 90.23  E-value: 8.38e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   481 EVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEftRKL 560
Cdd:pfam01576   79 ELESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKE--RKL 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   561 AEKSVEvlRLSSELQNLKATSDSLEseRVNKTDECEILQTEVRMRDEQ-----IRELNQQLDEVTTQLNVQKADSSALDD 635
Cdd:pfam01576  157 LEERIS--EFTSNLAEEEEKAKSLS--KLKNKHEAMISDLEERLKKEEkgrqeLEKAKRKLEGESTDLQEQIAELQAQIA 232

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   636 MLRLQKEGTEEK-STLLEKTEKELVQsKEQAAKTLndkEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQL 714
Cdd:pfam01576  233 ELRAQLAKKEEElQAALARLEEETAQ-KNNALKKI---RELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTEL 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   715 --------------ALKQNELEDFQKKQSES----EVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEK---- 772
Cdd:pfam01576  309 edtldttaaqqelrSKREQEVTELKKALEEEtrshEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESenae 388

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   773 LQAALEEL---KKEKETIIKEKEQELQQLQSKSAESESA---LKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKS 846
Cdd:pfam01576  389 LQAELRTLqqaKQDSEHKRKKLEGQLQELQARLSESERQraeLAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLES 468

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   847 QAEETQSELKS---TQSNLEAKSKQLEAANGSL----EEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLE 919
Cdd:pfam01576  469 QLQDTQELLQEetrQKLNLSTRLRQLEDERNSLqeqlEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKK 548

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   920 AANAALEKVNKEYAESRAEASDLQ---DKVKEITDTLHAELQAERSSSSALHTKLSKFSD------EIATGHKELTSKAD 990
Cdd:pfam01576  549 RLQRELEALTQQLEEKAAAYDKLEktkNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQmlaeekAISARYAEERDRAE 628

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   991 AWSQE----MLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKS----------FEESIKNLQEEVTKAKTENLELSTGT 1056
Cdd:pfam01576  629 AEAREketrALSLARALEEALEAKEELERTNKQLRAEMEDLVSSkddvgknvheLERSKRALEQQVEEMKTQLEELEDEL 708

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1057 QTTiKDLQERLEIT--------NAELQHKEKMASED----AQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKS 1124
Cdd:pfam01576  709 QAT-EDAKLRLEVNmqalkaqfERDLQARDEQGEEKrrqlVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQID 787

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1125 ETNHIFElfemEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSL 1204
Cdd:pfam01576  788 AANKGRE----EAVKQLKKLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQER 863

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1205 QELQDSV--------------KQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQL 1270
Cdd:pfam01576  864 DELADEIasgasgksalqdekRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQL 943

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1271 QEEAAKLSGELqqvQEANGDIKDslvKVEELVKVLEEKLQAATSQLDaQQATNKELQELLVKSQENEgnLQGESLAVTEK 1350
Cdd:pfam01576  944 ERQNKELKAKL---QEMEGTVKS---KFKSSIAALEAKIAQLEEQLE-QESRERQAANKLVRRTEKK--LKEVLLQVEDE 1014

                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442628156  1351 LQQLEQangeLKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQL 1421
Cdd:pfam01576 1015 RRHADQ----YKDQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQRELDDATESNESMNREVSTLKSKL 1081
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 841-1576 2.36e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 88.58  E-value: 2.36e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   841 ISQLKSQAEETQSELKSTQSNL---EAKSKQLEAANGSLEEEAKKSghllEQITKLKSEVGETQAALSschtdveskTKQ 917
Cdd:TIGR02168  167 ISKYKERRKETERKLERTRENLdrlEDILNELERQLKSLERQAEKA----ERYKELKAELRELELALL---------VLR 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   918 LEAANAALEKVNKEYAESRAEASDLQDKVKEiTDTLHAELQAErssssalHTKLSKFSDEIATGHKELTSKAdawsQEML 997
Cdd:TIGR02168  234 LEELREELEELQEELKEAEEELEELTAELQE-LEEKLEELRLE-------VSELEEEIEELQKELYALANEI----SRLE 301

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   998 QKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTEnlelstgtqttIKDLQERLEITNAELQHK 1077
Cdd:TIGR02168  302 QQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEE-----------LESLEAELEELEAELEEL 370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1078 EKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNS-ERLIEKVTGIKEELK 1156
Cdd:TIGR02168  371 ESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAElKELQAELEELEEELE 450

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1157 ETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIE--- 1233
Cdd:TIGR02168  451 ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSElis 530

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1234 -------AQNTKLNES--NVQLENktsclKETQDQLLESQKKEKQ---------LQEEAAKLSGELQQVQEANG--DIKD 1293
Cdd:TIGR02168  531 vdegyeaAIEAALGGRlqAVVVEN-----LNAAKKAIAFLKQNELgrvtflpldSIKGTEIQGNDREILKNIEGflGVAK 605

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1294 SLVKV-EELVKVLE---------EKLQAATSQ------------LDAQQAT---------NKELQELLVKSQENEgNLQG 1342
Cdd:TIGR02168  606 DLVKFdPKLRKALSyllggvlvvDDLDNALELakklrpgyrivtLDGDLVRpggvitggsAKTNSSILERRREIE-ELEE 684

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1343 ESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKS----HNEIQDKLEQAQQKERTLQEETSKLA 1418
Cdd:TIGR02168  685 KIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDlarlEAEVEQLEERIAQLSKELTELEAEIE 764

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1419 EQLSQLKQANEELQKSLQQKQLLLEKGNEF-------DTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQAN 1491
Cdd:TIGR02168  765 ELEERLEEAEEELAEAEAEIEELEAQIEQLkeelkalREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLE 844

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1492 DAQKTAYLETKELRRQLESL-----ELEKSREVLS-LKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQKN 1565
Cdd:TIGR02168  845 EQIEELSEDIESLAAEIEELeelieELESELEALLnERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKL 924

                          810
                   ....*....|.
gi 442628156  1566 DALKAKVQTLE 1576
Cdd:TIGR02168  925 AQLELRLEGLE 935
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1142-1522 4.51e-16

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 84.22  E-value: 4.51e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1142 ERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNL 1221
Cdd:COG1196   249 EELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAEL 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1222 EEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEEL 1301
Cdd:COG1196   329 EEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEA 408

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1302 VKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDE 1381
Cdd:COG1196   409 EEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAE 488

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1382 SNTVLESQkkshneiqdkleQAQQKERTLQEETSKLAEQLSQLKQANEELqkslqqkQLLLEKGNEFDTQLAEY------ 1455
Cdd:COG1196   489 AAARLLLL------------LEAEADYEGFLEGVKAALLLAGLRGLAGAV-------AVLIGVEAAYEAALEAAlaaalq 549

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442628156 1456 QKVIDEMDDAASVKSALLEQLQNRVAELE-TALRQANDAQKTAYLETKELRRQLESLELEKSREVLSL 1522
Cdd:COG1196   550 NIVVEDDEVAAAAIEYLKAAKAGRATFLPlDKIRARAALAAALARGAIGAAVDLVASDLREADARYYV 617
PTZ00121 PTZ00121
MAEBL; Provisional
 641-1417 8.32e-16

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 84.04  E-value: 8.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  641 KEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKE-QLEKQISDLKQLAEQEKlvremTENAiNQIQLEKESIEQQLALKQN 719
Cdd:PTZ00121 1121 KKKAEDARKAEEARKAEDARKAEEARKAEDAKRvEIARKAEDARKAEEARK-----AEDA-KKAEAARKAEEVRKAEELR 1194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  720 ELEDFQK----KQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQL-----EQKTLGHEKLQAALEELKKEKETIIKE 790
Cdd:PTZ00121 1195 KAEDARKaeaaRKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAkkaeeERNNEEIRKFEEARMAHFARRQAAIKA 1274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  791 KE----QELQQLQS--KSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEA 864
Cdd:PTZ00121 1275 EEarkaDELKKAEEkkKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEA 1354

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  865 KSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAE----AS 940
Cdd:PTZ00121 1355 AADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEekkkAD 1434

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  941 DLQDKVKEITDTLHAELQAE--RSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQT 1018
Cdd:PTZ00121 1435 EAKKKAEEAKKADEAKKKAEeaKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADE 1514

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1019 KLKAEGERKE---KSFEESIKNLQ----EEVTKA----KTENLELSTGTQTTIKDLQERlEITNAELQHKEKMASEDAQK 1087
Cdd:PTZ00121 1515 AKKAEEAKKAdeaKKAEEAKKADEakkaEEKKKAdelkKAEELKKAEEKKKAEEAKKAE-EDKNMALRKAEEAKKAEEAR 1593

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1088 IADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADmnSERLIEKVTGIKEELKETHLQLDERQK 1167
Cdd:PTZ00121 1594 IEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAE--EKKKAEELKKAEEENKIKAAEEAKKAE 1671

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1168 KFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEE---KVRESSSIIEAQNTKLNESNV 1244
Cdd:PTZ00121 1672 EDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEEnkiKAEEAKKEAEEDKKKAEEAKK 1751

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1245 QLE--NKTSCLKETQDQLLESQKKEKQL---QEEAAKLSGELQQVQEANGDIKDSLVKVEE-------LVKVLEEKLQAA 1312
Cdd:PTZ00121 1752 DEEekKKIAHLKKEEEKKAEEIRKEKEAvieEELDEEDEKRRMEVDKKIKDIFDNFANIIEggkegnlVINDSKEMEDSA 1831

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1313 TSQLDAQQATNKELQELLVKSQENEGNLQGESlAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKS 1392
Cdd:PTZ00121 1832 IKEVADSKNMQLEEADAFEKHKFNKNNENGED-GNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREIPNNNMAGK 1910

                         810       820
                  ....*....|....*....|....*.
gi 442628156 1393 HNE-IQDKLEQAQQKERTLQEETSKL 1417
Cdd:PTZ00121 1911 NNDiIDDKLDKDEYIKRDAEETREEI 1936
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1060-1568 2.26e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 82.29  E-value: 2.26e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1060 IKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADM 1139
Cdd:COG1196   234 LRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRE 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1140 NSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQ 1219
Cdd:COG1196   314 LEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALR 393

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1220 NLEEKVRESSSIIEAQNTKLNESNVQLENKTSC---LKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLV 1296
Cdd:COG1196   394 AAAELAAQLEELEEAEEALLERLERLEEELEELeeaLAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAA 473

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1297 KVEELVKVLEEKLQAATSQLDAQQATNKELQELL--VKSQENEGNLQGESLA--------------------------VT 1348
Cdd:COG1196   474 LLEAALAELLEELAEAAARLLLLLEAEADYEGFLegVKAALLLAGLRGLAGAvavligveaayeaaleaalaaalqniVV 553

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1349 EKLQQLEQANGELKEALCQKENGL---KELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQE---ETSKLAEQLS 1422
Cdd:COG1196   554 EDDEVAAAAIEYLKAAKAGRATFLpldKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDtllGRTLVAARLE 633

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1423 QLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETK 1502
Cdd:COG1196   634 AALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAE 713

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442628156 1503 ELRRQLESLELEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQKNDAL 1568
Cdd:COG1196   714 EERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAL 779
PTZ00121 PTZ00121
MAEBL; Provisional
 483-1303 2.40e-15

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 82.50  E-value: 2.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  483 ESRIAEQLEEEQRLRENVKylneQIATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLAE 562
Cdd:PTZ00121 1086 DNRADEATEEAFGKAEEAK----KTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAE 1161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  563 --KSVEVLRLSSELQNLKATSDSLE---SERVNKTDEC----------------EILQTEVRMRDEQIR---------EL 612
Cdd:PTZ00121 1162 daRKAEEARKAEDAKKAEAARKAEEvrkAEELRKAEDArkaeaarkaeeerkaeEARKAEDAKKAEAVKkaeeakkdaEE 1241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  613 NQQLDEVTTQLNVQKADSSALDDMLRLQKEG-TEEKSTLLEKTEKELVQSKEQAAKT--------LNDKEQLEKQISDLK 683
Cdd:PTZ00121 1242 AKKAEEERNNEEIRKFEEARMAHFARRQAAIkAEEARKADELKKAEEKKKADEAKKAeekkkadeAKKKAEEAKKADEAK 1321

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  684 QLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEI--KAQNTQKDFELVESGESLKKLQQ 761
Cdd:PTZ00121 1322 KKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAkkKADAAKKKAEEKKKADEAKKKAE 1401

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  762 QLEQKTLGHEKLQAA---LEELKKEKETIIKEKEQELQQLQSKSAES--ESALKVVQVQLEQLQQQAAASGEEGSKTvAK 836
Cdd:PTZ00121 1402 EDKKKADELKKAAAAkkkADEAKKKAEEKKKADEAKKKAEEAKKADEakKKAEEAKKAEEAKKKAEEAKKADEAKKK-AE 1480

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  837 LHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGsleEEAKKSGHLLEQITKLKSEvgETQAALSSCHTDVESKTK 916
Cdd:PTZ00121 1481 EAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKA---EEAKKADEAKKAEEAKKAD--EAKKAEEKKKADELKKAE 1555

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  917 QLEAANaalEKVNKEYAESRAEASDLQDKVKEITDTLHaelQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEM 996
Cdd:PTZ00121 1556 ELKKAE---EKKKAEEAKKAEEDKNMALRKAEEAKKAE---EARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAE 1629

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  997 LQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKnlqEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQH 1076
Cdd:PTZ00121 1630 EEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKK---AEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEE 1706

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1077 KEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEKVTGIKEELK 1156
Cdd:PTZ00121 1707 LKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELD 1786

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1157 EthlqldERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQN 1236
Cdd:PTZ00121 1787 E------EDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNEN 1860

                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442628156 1237 TKLNESNVQLENKTSCLKETQDQLLESqKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVK 1303
Cdd:PTZ00121 1861 GEDGNKEADFNKEKDLKEDDEEEIEEA-DEIEKIDKDDIEREIPNNNMAGKNNDIIDDKLDKDEYIK 1926
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 984-1512 2.65e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 81.91  E-value: 2.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  984 ELTSKADAWSQEMLQKEK----ELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTG---T 1056
Cdd:COG1196   228 ELLLLKLRELEAELEELEaeleELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDiarL 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1057 QTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEME 1136
Cdd:COG1196   308 EERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEE 387

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1137 ADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEE 1216
Cdd:COG1196   388 LLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAE 467

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1217 LVQNLEEKVRESSSIIEAQNTKLNESNVQLEnktsclKETQDQLLESQKKEKQLQEEAAKLSGELQQVQE---------- 1286
Cdd:COG1196   468 LLEEAALLEAALAELLEELAEAAARLLLLLE------AEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGveaayeaale 541

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1287 -------ANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKL-QQLEQAN 1358
Cdd:COG1196   542 aalaaalQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADArYYVLGDT 621

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1359 GELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQlkQANEELQKSLQQK 1438
Cdd:COG1196   622 LLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAE--RLAEEELELEEAL 699

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442628156 1439 QLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLE 1512
Cdd:COG1196   700 LAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLE 773
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1261-1551 2.82e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 81.91  E-value: 2.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1261 LESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVK---VLEEKLQAATSQLDAQQATNKELQELLVKSQENE 1337
Cdd:COG1196   218 LKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAelaELEAELEELRLELEELELELEEAQAEEYELLAEL 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1338 GNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKL 1417
Cdd:COG1196   298 ARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEA 377

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1418 AEQLSQLKQANEELQKS-----------LQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETA 1486
Cdd:COG1196   378 EEELEELAEELLEALRAaaelaaqleelEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEE 457

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442628156 1487 LRQANDAQKTAYLETKELRRQLESLELEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKI 1551
Cdd:COG1196   458 EEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGL 522
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 348-958 5.10e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 81.14  E-value: 5.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  348 QDLLREKQQHVEKLmvERDldREDAQnQALQLQKNINELKA-----RIVELESALDNERKKTEELQCSIDEAQFCGDELN 422
Cdd:COG1196   192 EDILGELERQLEPL--ERQ--AEKAE-RYRELKEELKELEAellllKLRELEAELEELEAELEELEAELEELEAELAELE 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  423 AQSQVYKEKIHDLESKITklvsatpslqsilppdlpsddgALQEEIAKLQEkmtiQQKEVESRIAEQLEEEQRLRENVKY 502
Cdd:COG1196   267 AELEELRLELEELELELE----------------------EAQAEEYELLA----ELARLEQDIARLEERRRELEERLEE 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  503 LNEQIATLQSELVSKDEALEkfslsecgienlrrelelLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSD 582
Cdd:COG1196   321 LEEELAELEEELEELEEELE------------------ELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELE 382

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  583 SLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSK 662
Cdd:COG1196   383 ELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALL 462

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  663 EQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQN-----ELEDFQKKQSESEVHLQE 737
Cdd:COG1196   463 ELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLrglagAVAVLIGVEAAYEAALEA 542

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  738 IKAQNTQKDfeLVESGESLKKLQQQLEQKTLG------------HEKLQAALEELKKEKETIIKEKEQELQQLQSKSAES 805
Cdd:COG1196   543 ALAAALQNI--VVEDDEVAAAAIEYLKAAKAGratflpldkiraRAALAAALARGAIGAAVDLVASDLREADARYYVLGD 620

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  806 ESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELkstQSNLEAKSKQLEAANGSLEEEAKKSGH 885
Cdd:COG1196   621 TLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRREL---LAALLEAEAELEELAERLAEEELELEE 697

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442628156  886 LLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQ 958
Cdd:COG1196   698 ALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELE 770
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1258-1576 5.76e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 80.87  E-value: 5.76e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1258 DQLLESQKKE-KQLQEEAAKLSGELQQVQEANG---DIKDSLVKVEELVKVLEEKLQAATSQldAQQAtnKELQELlvKS 1333
Cdd:TIGR02168  147 SEIIEAKPEErRAIFEEAAGISKYKERRKETERkleRTRENLDRLEDILNELERQLKSLERQ--AEKA--ERYKEL--KA 220

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1334 QENEGNLQGESLAVTEKLQQLEQANGELKEA---LCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTL 1410
Cdd:TIGR02168  221 ELRELELALLVLRLEELREELEELQEELKEAeeeLEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRL 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1411 QEETSKLAEQLSQL----KQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETA 1486
Cdd:TIGR02168  301 EQQKQILRERLANLerqlEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQ 380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1487 LRQANDAQKTAYLETKELRRQLESLELEKSRevlSLKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQKND 1566
Cdd:TIGR02168  381 LETLRSKVAQLELQIASLNNEIERLEARLER---LEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELE 457

                          330
                   ....*....|
gi 442628156  1567 ALKAKVQTLE 1576
Cdd:TIGR02168  458 RLEEALEELR 467
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 548-1477 6.07e-15

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 80.86  E-value: 6.07e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   548 QAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQK 627
Cdd:TIGR00606  203 QEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALKSRKKQME 282

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   628 ADSSALDDMLRLQKEGTEEKSTLLE--------KTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENA 699
Cdd:TIGR00606  283 KDNSELELKMEKVFQGTDEQLNDLYhnhqrtvrEKERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEH 362

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   700 INQIQLEKESIEQQLALKQNELEDFQKKQSESEVHL----QEIKAQNTQKDFELVESGESLKKlqqqlEQKTLGHEKLQA 775
Cdd:TIGR00606  363 IRARDSLIQSLATRLELDGFERGPFSERQIKNFHTLvierQEDEAKTAAQLCADLQSKERLKQ-----EQADEIRDEKKG 437

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   776 ALEELKKEKETIIKEKEQ---ELQQLQSKSAESESALKVVQVQLEQLQQQAAAsgEEGSKTVAKLHDEISQLKSQAEETQ 852
Cdd:TIGR00606  438 LGRTIELKKEILEKKQEElkfVIKELQQLEGSSDRILELDQELRKAERELSKA--EKNSLTETLKKEVKSLQNEKADLDR 515

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   853 SELKSTQSNleAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDveskTKQLEAAnaaLEKVNKEY 932
Cdd:TIGR00606  516 KLRKLDQEM--EQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFPN----KKQLEDW---LHSKSKEI 586

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   933 AESRAEASDLQDKVKEITDTLHAELQAERSsssaLHTKLSKFSDEI--ATGHKELTSKADAWSQEMLQKEKELQELRQQL 1010
Cdd:TIGR00606  587 NQTRDRLAKLNKELASLEQNKNHINNELES----KEEQLSSYEDKLfdVCGSQDEESDLERLKEEIEKSSKQRAMLAGAT 662

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1011 QDSQDSQTKLKAEgerkeksfEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIAD 1090
Cdd:TIGR00606  663 AVYSQFITQLTDE--------NQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPG 734

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1091 LKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFElfEMEADMNSERLIEKVTGIKEELKEthlQLDERQKKFE 1170
Cdd:TIGR00606  735 RQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLG--TIMPEEESAKVCLTDVTIMERFQM---ELKDVERKIA 809

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1171 ELEEKLKQA--QQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVREsssiieaqntklnesnvqlen 1248
Cdd:TIGR00606  810 QQAAKLQGSdlDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNE--------------------- 868

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1249 ktscLKETQDQLLESQKKEKQLQEEAAKLSGElqqVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQE 1328
Cdd:TIGR00606  869 ----LKSEKLQIGTNLQRRQQFEEQLVELSTE---VQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQD 941

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1329 LLVKSQENEGNLQGESLAVTEKLQQLEQangelkEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKER 1408
Cdd:TIGR00606  942 KVNDIKEKVKNIHGYMKDIENKIQDGKD------DYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQER 1015

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442628156  1409 TLQEETS--KLAEQLSQLKQANEELQKSLQQKQLLLEKgnefdtqlAEYQKVIDEMDDAASVKSALLEQLQ 1477
Cdd:TIGR00606 1016 WLQDNLTlrKRENELKEVEEELKQHLKEMGQMQVLQMK--------QEHQKLEENIDLIKRNHVLALGRQK 1078
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 994-1512 1.15e-14

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 79.68  E-value: 1.15e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   994 QEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEevTKAKTENLELS-TGTQTTIKDLQERLEITNA 1072
Cdd:TIGR04523  117 EQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYND--LKKQKEELENElNLLEKEKLNIQKNIDKIKN 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1073 ELQHKEKMASEDAQKIADLKTLVEAIqvanANISATNAELSTVLEVLQAEKSETNHIFElfemEADMNSERLIEKVTGIK 1152
Cdd:TIGR04523  195 KLLKLELLLSNLKKKIQKNKSLESQI----SELKKQNNQLKDNIEKKQQEINEKTTEIS----NTQTQLNQLKDEQNKIK 266

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1153 EELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQtskeklteiQQSLQELQDSVKQKEELVQNLEEKVRESSSII 1232
Cdd:TIGR04523  267 KQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKE---------QDWNKELKSELKNQEKKLEEIQNQISQNNKII 337

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1233 EAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAA 1312
Cdd:TIGR04523  338 SQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKL 417

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1313 TSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKS 1392
Cdd:TIGR04523  418 QQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKE 497

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1393 HNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKgNEFDTQLAEYQKVIDEMDDAasvksal 1472
Cdd:TIGR04523  498 LKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNK-DDFELKKENLEKEIDEKNKE------- 569

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 442628156  1473 LEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLE 1512
Cdd:TIGR04523  570 IEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKE 609
PTZ00121 PTZ00121
MAEBL; Provisional
 642-1350 2.06e-14

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 79.41  E-value: 2.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  642 EGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTE-NAINQIQLEKESIEQQLALKQNE 720
Cdd:PTZ00121 1080 DFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKaEDARKAEEARKAEDAKRVEIARK 1159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  721 LEDFQK----------KQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKEtiIKE 790
Cdd:PTZ00121 1160 AEDARKaeearkaedaKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEE--AKK 1237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  791 KEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKtvAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLE 870
Cdd:PTZ00121 1238 DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARK--ADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAK 1315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  871 AAngslEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEIT 950
Cdd:PTZ00121 1316 KA----DEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKK 1391

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  951 DTLHAELQAERSSSSALHTK---LSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERK 1027
Cdd:PTZ00121 1392 KADEAKKKAEEDKKKADELKkaaAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKK 1471

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1028 ---------EKSFEESIKNLQEEvTKAKTENLELSTGTQTTIKDLQERLEITNAElqhkEKMASEDAQKIADLKTLVEAI 1098
Cdd:PTZ00121 1472 adeakkkaeEAKKADEAKKKAEE-AKKKADEAKKAAEAKKKADEAKKAEEAKKAD----EAKKAEEAKKADEAKKAEEKK 1546

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1099 QVANANISATNAELSTVLEVLQAEKSETNHIFELFEME-ADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLK 1177
Cdd:PTZ00121 1547 KADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEeAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELK 1626

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1178 QAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKlnesnvqlenktsclKETQ 1257
Cdd:PTZ00121 1627 KAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDE---------------KKAA 1691

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1258 DQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAAtSQLDAQQATNKELQELLVKSQENE 1337
Cdd:PTZ00121 1692 EALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKA-EEAKKDEEEKKKIAHLKKEEEKKA 1770

                         730
                  ....*....|...
gi 442628156 1338 GNLQGESLAVTEK 1350
Cdd:PTZ00121 1771 EEIRKEKEAVIEE 1783
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
832-1421 6.40e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 77.41  E-value: 6.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  832 KTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKsghlLEQITKLKSEVGETQAALSSCHTDV 911
Cdd:PRK03918  172 KEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREE----LEKLEKEVKELEELKEEIEELEKEL 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  912 ESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITdtlhaELQAERSSSSALHTKLSKFSDEIATGHKELTSkada 991
Cdd:PRK03918  248 ESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELK-----ELKEKAEEYIKLSEFYEEYLDELREIEKRLSR---- 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  992 WSQEMLQKEKELQELRQQLQDSQDSQTKLKaEGERKEKSFEESIKNLQEevTKAKTENLE-----LSTGTQTTIKDLQER 1066
Cdd:PRK03918  319 LEEEINGIEERIKELEEKEERLEELKKKLK-ELEKRLEELEERHELYEE--AKAKKEELErlkkrLTGLTPEKLEKELEE 395

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1067 LEITNAELQHKEK----MASEDAQKIADLKTLVEAIQVANANISATNAELS-----TVLEVLQAE-KSETNHIFELFEME 1136
Cdd:PRK03918  396 LEKAKEEIEEEISkitaRIGELKKEIKELKKAIEELKKAKGKCPVCGRELTeehrkELLEEYTAElKRIEKELKEIEEKE 475

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1137 ADMNSE-RLIEKVTGIKEEL---KETHLQLDERQKKFEELE-EKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSV 1211
Cdd:PRK03918  476 RKLRKElRELEKVLKKESELiklKELAEQLKELEEKLKKYNlEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELK 555

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1212 KQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDI 1291
Cdd:PRK03918  556 KKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEEL 635

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1292 KDSLVKVEELVKVLEEKLQAATsqldaqQATNKELQELLVKsqenegnLQGESLAVTEKLQQLEQANGELKEALCQKENG 1371
Cdd:PRK03918  636 AETEKRLEELRKELEELEKKYS------EEEYEELREEYLE-------LSRELAGLRAELEELEKRREEIKKTLEKLKEE 702

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|..
gi 442628156 1372 LKELQGKLDESNtVLESQKKSHNEIQDKLE--QAQQKERTLQeETSKLAEQL 1421
Cdd:PRK03918  703 LEEREKAKKELE-KLEKALERVEELREKVKkyKALLKERALS-KVGEIASEI 752
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 604-1423 6.62e-14

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 77.47  E-value: 6.62e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   604 MRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELvqskeQAAKTLNdkeqlEKQISDLK 683
Cdd:pfam15921  100 LHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHEL-----EAAKCLK-----EDMLEDSN 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   684 QLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNEledfqkKQSESEVHLQEIKAQNTQKDFELVESGESLK----KL 759
Cdd:pfam15921  170 TQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKKIYE------HDSMSTMHFRSLGSAISKILRELDTEISYLKgrifPV 243

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   760 QQQLEQ-KTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLH 838
Cdd:pfam15921  244 EDQLEAlKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLE 323

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   839 DEISQLKSQAEETQselKSTQSNLEAKSKQLEAANGSLEEE-------AKKSGHLLEQITKLKSEVGETQAALSSCHTDV 911
Cdd:pfam15921  324 STVSQLRSELREAK---RMYEDKIEELEKQLVLANSELTEArterdqfSQESGNLDDQLQKLLADLHKREKELSLEKEQN 400

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   912 ESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSdeiatghkELTSKADA 991
Cdd:pfam15921  401 KRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVS--------SLTAQLES 472

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   992 wSQEMLQKEKElqelrqqlqdsqdSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLElstgtqttIKDLQERLEITN 1071
Cdd:pfam15921  473 -TKEMLRKVVE-------------ELTAKKMTLESSERTVSDLTASLQEKERAIEATNAE--------ITKLRSRVDLKL 530

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1072 AELQHkekmasedaqkiadLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEKVTGI 1151
Cdd:pfam15921  531 QELQH--------------LKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLE 596

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1152 KE------ELKETHLQLDERQKKFEELE--------EKLKQAQQSEQKLQQESQTSKEK---LTEIQQSLQELQDSVKQK 1214
Cdd:pfam15921  597 KEindrrlELQEFKILKDKKDAKIRELEarvsdlelEKVKLVNAGSERLRAVKDIKQERdqlLNEVKTSRNELNSLSEDY 676

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1215 EELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDS 1294
Cdd:pfam15921  677 EVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEA 756

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1295 LVKVEELVKVLEEKLQAATSQLDA-QQATNKELQEL-LVKSQEN---------EGNLQGESLAVTE---KLQQLEQANGE 1360
Cdd:pfam15921  757 MTNANKEKHFLKEEKNKLSQELSTvATEKNKMAGELeVLRSQERrlkekvanmEVALDKASLQFAEcqdIIQRQEQESVR 836

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442628156  1361 LKealCQKENGLKELQGKLDESNTVLE-------SQKKSHNEIQDK------LEQAQQKERTLQEETSKLAEQLSQ 1423
Cdd:pfam15921  837 LK---LQHTLDVKELQGPGYTSNSSMKprllqpaSFTRTHSNVPSSqstasfLSHHSRKTNALKEDPTRDLKQLLQ 909
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 608-1512 1.08e-13

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 76.75  E-value: 1.08e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   608 QIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEK--TEKEL-VQSKEQAAKTLNDKEQLEKQISDLKQ 684
Cdd:pfam01576    3 QEEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQlqAETELcAEAEEMRARLAARKQELEEILHELES 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   685 LAEQEklvremtENAINQIQLEKESIEQQLAlkqneledfqkkqsESEVHLQEIKAQNTQKDFELVESGESLKKLQQQ-- 762
Cdd:pfam01576   83 RLEEE-------EERSQQLQNEKKKMQQHIQ--------------DLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDil 141

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   763 -LEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALkvvqVQLEQLQQQAAASGEEGSKTVAKLHDEI 841
Cdd:pfam01576  142 lLEDQNSKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKNKHEAMI----SDLEERLKKEEKGRQELEKAKRKLEGES 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   842 SQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQ---- 917
Cdd:pfam01576  218 TDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQrrdl 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   918 ---LEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQ 994
Cdd:pfam01576  298 geeLEALKTELEDTLDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEK 377

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   995 EMLQKEKELQELrqqlQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELstgtQTTIKDLQERLEITNAEL 1074
Cdd:pfam01576  378 AKQALESENAEL----QAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAEL----AEKLSKLQSELESVSSLL 449

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1075 QHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELfEMEADMNSERliekvtgikeE 1154
Cdd:pfam01576  450 NEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEE-EEEAKRNVER----------Q 518

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1155 LKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTE--------------IQQSLQELQDSVKQKEELVQN 1220
Cdd:pfam01576  519 LSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEkaaaydklektknrLQQELDDLLVDLDHQRQLVSN 598

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1221 LEEKVRESSSII---EAQNTKLNESNVQLENK-----------TSCLKETQDQLLESQKKEKQLQEE----------AAK 1276
Cdd:pfam01576  599 LEKKQKKFDQMLaeeKAISARYAEERDRAEAEareketralslARALEEALEAKEELERTNKQLRAEmedlvsskddVGK 678

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1277 LSGEL--------QQVQEANG---DIKDSLVKVEELVKVLEEKLQAATSQ----LDAQQATNKELQELLVKS-------Q 1334
Cdd:pfam01576  679 NVHELerskraleQQVEEMKTqleELEDELQATEDAKLRLEVNMQALKAQferdLQARDEQGEEKRRQLVKQvreleaeL 758

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1335 ENEGNLQGESLAVTEKLQ--------QLEQANGELKEALCQkengLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQK 1406
Cdd:pfam01576  759 EDERKQRAQAVAAKKKLEldlkeleaQIDAANKGREEAVKQ----LKKLQAQMKDLQRELEEARASRDEILAQSKESEKK 834

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1407 ERTLQEETSKLAEQLSQLKQAN-----------EELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDE-------MDDAASV 1468
Cdd:pfam01576  835 LKNLEAELLQLQEDLAASERARrqaqqerdelaDEIASGASGKSALQDEKRRLEARIAQLEEELEEeqsntelLNDRLRK 914

                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....
gi 442628156  1469 KSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLE 1512
Cdd:pfam01576  915 STLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQEME 958
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 847-1538 1.91e-13

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 75.78  E-value: 1.91e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   847 QAEETQSELKSTQSNLEAKSKQLEAANgSLEEEAKKSGHLLEQITKLKSEVGETQAALsschtDVESKTKQLEAANAALE 926
Cdd:TIGR00618  230 HLREALQQTQQSHAYLTQKREAQEEQL-KKQQLLKQLRARIEELRAQEAVLEETQERI-----NRARKAAPLAAHIKAVT 303

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   927 KVNKEYAESRAEasdLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKEL-TSKADAWSQEMLQKEKELQE 1005
Cdd:TIGR00618  304 QIEQQAQRIHTE---LQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDaHEVATSIREISCQQHTLTQH 380

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1006 LRQQLQDSQDSQTKLKAEGERKEKsfeesiknLQEEVTKAKTENLELSTGTQ------TTIKDLQERLEITNA------- 1072
Cdd:TIGR00618  381 IHTLQQQKTTLTQKLQSLCKELDI--------LQREQATIDTRTSAFRDLQGqlahakKQQELQQRYAELCAAaitctaq 452

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1073 ELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSE--------TNHIFELFEMEADMNS-ER 1143
Cdd:TIGR00618  453 CEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPlcgscihpNPARQDIDNPGPLTRRmQR 532

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1144 LIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSvkqkeelvqnLEE 1223
Cdd:TIGR00618  533 GEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDL----------TEK 602

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1224 KVRESSSIIEAQNTKLNESNVQLENktsclketQDQLLESQKKEKQLQEEAAKLSGELQQVqeANGDIKDSLVKVEELVK 1303
Cdd:TIGR00618  603 LSEAEDMLACEQHALLRKLQPEQDL--------QDVRLHLQQCSQELALKLTALHALQLTL--TQERVREHALSIRVLPK 672

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1304 VLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESN 1383
Cdd:TIGR00618  673 ELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQA 752

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1384 TvlESQKKSHNEIQDKLEQAQQKERTLQEetsklaeqLSQLKQANEELQKSLQQKQLLLEkgnefdTQLAEYQKVIDEMD 1463
Cdd:TIGR00618  753 R--TVLKARTEAHFNNNEEVTAALQTGAE--------LSHLAAEIQFFNRLREEDTHLLK------TLEAEIGQEIPSDE 816

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442628156  1464 DAASVKSALL----EQLQNRVAELETALRQAndaqKTAYLETKELRRQLESLeLEKSREVLSLKAQMNGASSRSGKGDE 1538
Cdd:TIGR00618  817 DILNLQCETLvqeeEQFLSRLEEKSATLGEI----THQLLKYEECSKQLAQL-TQEQAKIIQLSDKLNGINQIKIQFDG 890
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1061-1523 2.31e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 75.49  E-value: 2.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1061 KDLQERLEITNAELQHKEK--MASEDAQ-KIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEmEA 1137
Cdd:PRK03918  165 KNLGEVIKEIKRRIERLEKfiKRTENIEeLIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIE-EL 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1138 DMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKlQQESQTSKEKLTEIQQSLQELQDSVKQKEEL 1217
Cdd:PRK03918  244 EKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEK-AEEYIKLSEFYEEYLDELREIEKRLSRLEEE 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1218 VQNLEEKVRESSSIiEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSG--------ELQQVQEANG 1289
Cdd:PRK03918  323 INGIEERIKELEEK-EERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGltpeklekELEELEKAKE 401

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1290 DIKDSLVKVEELVKVLEEK---LQAATSQLDAQQAT----NKELQEllvksqENEGNLQGEslaVTEKLQQLEQANGELK 1362
Cdd:PRK03918  402 EIEEEISKITARIGELKKEikeLKKAIEELKKAKGKcpvcGRELTE------EHRKELLEE---YTAELKRIEKELKEIE 472

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1363 EALCQKENGLKELQGKLDESNTV------------LESQKKSHNeiQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEE 1430
Cdd:PRK03918  473 EKERKLRKELRELEKVLKKESELiklkelaeqlkeLEEKLKKYN--LEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEK 550

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1431 LQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAAsvksalLEQLQNRVAELETALRQANDAQKTAY-LETKELRRQLE 1509
Cdd:PRK03918  551 LEELKKKLAELEKKLDELEEELAELLKELEELGFES------VEELEERLKELEPFYNEYLELKDAEKeLEREEKELKKL 624

                         490
                  ....*....|....
gi 442628156 1510 SLELEKSREVLSLK 1523
Cdd:PRK03918  625 EEELDKAFEELAET 638
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
632-1222 3.35e-13

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 75.08  E-value: 3.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  632 ALDDMLRLQKEGTEE-KSTLLEKTEKELVqskeqaaKTLNDKEQLEKQI-SDLKQLAEQEKLVREMTENAINQIQLEKES 709
Cdd:PRK02224  177 GVERVLSDQRGSLDQlKAQIEEKEEKDLH-------ERLNGLESELAELdEEIERYEEQREQARETRDEADEVLEEHEER 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  710 IEQQLALKQnELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIK 789
Cdd:PRK02224  250 REELETLEA-EIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRD 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  790 EKEQELQQLQSKSAESESALKVVQVQLEQLqqqaaasgeegsktvAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQL 869
Cdd:PRK02224  329 RLEECRVAAQAHNEEAESLREDADDLEERA---------------EELREEAAELESELEEAREAVEDRREEIEELEEEI 393

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  870 EAANGS-------LEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDL 942
Cdd:PRK02224  394 EELRERfgdapvdLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGKCPECGQPVEGSPHVETIEED 473

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  943 QDKVKEITDTLhAELQAERSSSSALHTKLSKFSdEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKA 1022
Cdd:PRK02224  474 RERVEELEAEL-EDLEEEVEEVEERLERAEDLV-EAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEA 551

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1023 EGERKEKSFEESIKNLQEevtkaktenlelstgTQTTIKDLQERLEITNAELQHKEKMASEDAqKIADLKTLVEAIQVAN 1102
Cdd:PRK02224  552 EAEEKREAAAEAEEEAEE---------------AREEVAELNSKLAELKERIESLERIRTLLA-AIADAEDEIERLREKR 615

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1103 ANISATNAELSTVLevlqAEKSETNHifelfEMEADMNSERLiekvtgikEELKETHLQLDERQkkfEELEEKLKQAQQS 1182
Cdd:PRK02224  616 EALAELNDERRERL----AEKRERKR-----ELEAEFDEARI--------EEAREDKERAEEYL---EQVEEKLDELREE 675

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|
gi 442628156 1183 EQKLQQESQTSKEKLTEiqqsLQELQDSVKQKEELVQNLE 1222
Cdd:PRK02224  676 RDDLQAEIGAVENELEE----LEELRERREALENRVEALE 711
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
633-1227 3.91e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 74.72  E-value: 3.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  633 LDDMLRLQKEGTEEKSTLLEKTE------KELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLE 706
Cdd:PRK03918  167 LGEVIKEIKRRIERLEKFIKRTEnieeliKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKE 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  707 KESIEQQLALKQNELEDFQKKQSESEVHLQEI--KAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELkkek 784
Cdd:PRK03918  247 LESLEGSKRKLEEKIRELEERIEELKKEIEELeeKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEE---- 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  785 etiIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQaaasgeegsKTVAKLHDEISQLKSQAEETQSELKS-TQSNLE 863
Cdd:PRK03918  323 ---INGIEERIKELEEKEERLEELKKKLKELEKRLEEL---------EERHELYEEAKAKKEELERLKKRLTGlTPEKLE 390

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  864 AKSKQLEAANGSLEEEAKKsghLLEQITKLKSEVGETQAALSS-------CHT-----DVESKTKQLEAANAALEKVNKE 931
Cdd:PRK03918  391 KELEELEKAKEEIEEEISK---ITARIGELKKEIKELKKAIEElkkakgkCPVcgrelTEEHRKELLEEYTAELKRIEKE 467

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  932 YAESRAEASDLQDKVKEITDTLHAELQAerssssalhTKLSKFSDEIatghKELTSKADAWSQEML-QKEKELQELRQQL 1010
Cdd:PRK03918  468 LKEIEEKERKLRKELRELEKVLKKESEL---------IKLKELAEQL----KELEEKLKKYNLEELeKKAEEYEKLKEKL 534

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1011 QDSQDSQTKLKAEGERKE------KSFEESIKNLQEEVTKAKTENLELSTGtqtTIKDLQERLEitNAELQHKEKMASED 1084
Cdd:PRK03918  535 IKLKGEIKSLKKELEKLEelkkklAELEKKLDELEEELAELLKELEELGFE---SVEELEERLK--ELEPFYNEYLELKD 609

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1085 AQKiaDLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFemeadmnSERLIEKVTGIKEELKETHLQLDE 1164
Cdd:PRK03918  610 AEK--ELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKY-------SEEEYEELREEYLELSRELAGLRA 680

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442628156 1165 RqkkFEELEEKLKQAQQSEQKLqqesqtsKEKLTEIQQSLQELQDSVKQKEElVQNLEEKVRE 1227
Cdd:PRK03918  681 E---LEELEKRREEIKKTLEKL-------KEELEEREKAKKELEKLEKALER-VEELREKVKK 732
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 376-1279 5.09e-13

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 74.62  E-value: 5.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   376 ALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQFCGDEL-NAQSQVYKEKIHDLESKITKLVSATPSLQSIL- 453
Cdd:pfam02463  182 TENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLyLDYLKLNEERIDLLQELLRDEQEEIESSKQEIe 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   454 -PPDLPSDDGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIE 532
Cdd:pfam02463  262 kEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELE 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   533 NLRRELELLKEENEKQAQEAQAEftrklaeksvevLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIREL 612
Cdd:pfam02463  342 KELKELEIKREAEEEEEEELEKL------------QEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQL 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   613 NQQLdevttqLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLV 692
Cdd:pfam02463  410 LLEL------ARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQ 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   693 REMTEnainQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKT----- 767
Cdd:pfam02463  484 EQLEL----LLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSatade 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   768 -LGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAES-------ESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHD 839
Cdd:pfam02463  560 vEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEidpilnlAQLDKATLEADEDDKRAKVVEGILKDTELTKLKE 639

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   840 EISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSScHTDVESKTKQLE 919
Cdd:pfam02463  640 SAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQ-REKEELKKLKLE 718

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   920 AANAALEKVNKEYAESRAEASDLQDKVKEITDTlhaELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQK 999
Cdd:pfam02463  719 AEELLADRVQEAQDKINEELKLLKQKIDEEEEE---EEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEK 795

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1000 EKELQELRQQLQDsqdsqtKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEK 1079
Cdd:pfam02463  796 LKAQEEELRALEE------ELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELL 869

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1080 MASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFElfemeadmnsERLIEKVTGIKEELKETH 1159
Cdd:pfam02463  870 QELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEE----------RIKEEAEILLKYEEEPEE 939

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1160 LQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKL 1239
Cdd:pfam02463  940 LLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQRL 1019

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|
gi 442628156  1240 NESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSG 1279
Cdd:pfam02463 1020 KEFLELFVSINKGWNKVFFYLELGGSAELRLEDPDDPFSG 1059
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 342-1002 5.49e-13

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 74.38  E-value: 5.49e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   342 KSQFSMQDLLREKQQHVEKLMVERD----LDREDAQNQA---LQLQKNINELKARIVELESALDNERKKTEELQ------ 408
Cdd:pfam15921  103 KQKFYLRQSVIDLQTKLQEMQMERDamadIRRRESQSQEdlrNQLQNTVHELEAAKCLKEDMLEDSNTQIEQLRkmmlsh 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   409 ---------CSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTI-- 477
Cdd:pfam15921  183 egvlqeirsILVDFEEASGKKIYEHDSMSTMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELll 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   478 --QQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSEL-VSKDEALEKFSLSECGIENLRRELELLKEenekQAQEAQA 554
Cdd:pfam15921  263 qqHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLeIIQEQARNQNSMYMRQLSDLESTVSQLRS----ELREAKR 338

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   555 EFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQI---RELNQQL-----------DEVT 620
Cdd:pfam15921  339 MYEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELsleKEQNKRLwdrdtgnsitiDHLR 418

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   621 TQLNVQKADSSALDDMLRLQKE----GTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLK----QLAEQEKLV 692
Cdd:pfam15921  419 RELDDRNMEVQRLEALLKAMKSecqgQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTakkmTLESSERTV 498

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   693 REMT------ENAINQIQLEKESIEQQLALKQNELEDFQKKQSesevHLQEIKAQNTQKDFELVESGESLKKLQQQLEQK 766
Cdd:pfam15921  499 SDLTaslqekERAIEATNAEITKLRSRVDLKLQELQHLKNEGD----HLRNVQTECEALKLQMAEKDKVIEILRQQIENM 574

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   767 TL---GHEKLQAALEELKKEKETIIKEKEQELQQ---LQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDE 840
Cdd:pfam15921  575 TQlvgQHGRTAGAMQVEKAQLEKEINDRRLELQEfkiLKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQE 654

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   841 ISQLKSQAEETQSELKS-------TQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQI-TKLKSEVGETQAALS---SCHT 909
Cdd:pfam15921  655 RDQLLNEVKTSRNELNSlsedyevLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTrNTLKSMEGSDGHAMKvamGMQK 734

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   910 DVESKTKQLEAANA-------ALEKVNKEYAESRAEASDLQDKVKEIT---DTLHAELQAERSSSSALHTKLSKFsdEIA 979
Cdd:pfam15921  735 QITAKRGQIDALQSkiqfleeAMTNANKEKHFLKEEKNKLSQELSTVAtekNKMAGELEVLRSQERRLKEKVANM--EVA 812

                          730       740
                   ....*....|....*....|...
gi 442628156   980 TGHKELTSkadAWSQEMLQKEKE 1002
Cdd:pfam15921  813 LDKASLQF---AECQDIIQRQEQ 832
PRK11281 PRK11281
mechanosensitive channel MscK;
1151-1527 1.88e-12

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 72.64  E-value: 1.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1151 IKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQesqtskeklteIQQSLQELQDSvkQKEELVQNLeekvrESSS 1230
Cdd:PRK11281   61 VQQDLEQTLALLDKIDRQKEETEQLKQQLAQAPAKLRQ-----------AQAELEALKDD--NDEETRETL-----STLS 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1231 IIEAQNtKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQeeaAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQ 1310
Cdd:PRK11281  123 LRQLES-RLAQTLDQLQNAQNDLAEYNSQLVSLQTQPERAQ---AALYANSQRLQQIRNLLKGGKVGGKALRPSQRVLLQ 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1311 AATSQLDAQQ-------ATNKELQELLvKSQENEgnlqgeslaVTEKLQQLEQANGELKEALCQKEngLKELQGKLDESN 1383
Cdd:PRK11281  199 AEQALLNAQNdlqrkslEGNTQLQDLL-QKQRDY---------LTARIQRLEHQLQLLQEAINSKR--LTLSEKTVQEAQ 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1384 TVLESQKKSHNE-IQDKLEQAQQKERTLQEETSKLAE----------QLSQLKQAN---EE----LQKSL-------QQK 1438
Cdd:PRK11281  267 SQDEAARIQANPlVAQELEINLQLSQRLLKATEKLNTltqqnlrvknWLDRLTQSErniKEqisvLKGSLllsrilyQQQ 346

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1439 QLL--LEKGNEFDTQLAE---YQKVIDEMDDAasvksalLEQLQNRVAELEtalrqANDAQKtaylETKELRRQLESLeL 1513
Cdd:PRK11281  347 QALpsADLIEGLADRIADlrlEQFEINQQRDA-------LFQPDAYIDKLE-----AGHKSE----VTDEVRDALLQL-L 409

                         410
                  ....*....|....*....
gi 442628156 1514 EKSREVL-----SLKAQMN 1527
Cdd:PRK11281  410 DERRELLdqlnkQLNNQLN 428
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 346-1071 1.94e-12

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 72.36  E-value: 1.94e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   346 SMQDLLREKQQHVEKLMVERDLDREDAQNqalqLQKNINELKARIVELESALDNERKKTEELQCSIdeaqfcgDELNAQS 425
Cdd:TIGR04523   44 TIKNELKNKEKELKNLDKNLNKDEEKINN----SNNKIKILEQQIKDLNDKLKKNKDKINKLNSDL-------SKINSEI 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   426 QVYKEKIHDLESKITKLvsatpslqsilppdlpsddgalqeeiaklqEKmtiQQKEVESRIAEQLEEEQRLRENVKYLNE 505
Cdd:TIGR04523  113 KNDKEQKNKLEVELNKL------------------------------EK---QKKENKKNIDKFLTEIKKKEKELEKLNN 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   506 QIATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKqaqeaqaeFTRKLAEKSVEVLRLSSELQNLKATSDSLE 585
Cdd:TIGR04523  160 KYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLEL--------LLSNLKKKIQKNKSLESQISELKKQNNQLK 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   586 SERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLN-----VQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQ 660
Cdd:TIGR04523  232 DNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSekqkeLEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKE 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   661 SKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKkqsESEVHLQEIKA 740
Cdd:TIGR04523  312 LKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKK---ENQSYKQEIKN 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   741 QNTQKdfelvesgeslKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEkEQELQQLQSKSAESESALKVVQVQLEqlq 820
Cdd:TIGR04523  389 LESQI-----------NDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKE-IERLKETIIKNNSEIKDLTNQDSVKE--- 453

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   821 qqaaasgeegsKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVG-- 898
Cdd:TIGR04523  454 -----------LIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISsl 522

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   899 -ETQAALSSCHTDVESKTKQLEAanaalEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDE 977
Cdd:TIGR04523  523 kEKIEKLESEKKEKESKISDLED-----ELNKDDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKE 597

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   978 IatghKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAegerKEKSFEESIKNLQEEVTKAKTENLELSTGTQ 1057
Cdd:TIGR04523  598 K----KDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKS----KKNKLKQEVKQIKETIKEIRNKWPEIIKKIK 669

                          730
                   ....*....|....
gi 442628156  1058 TTIKDLQERLEITN 1071
Cdd:TIGR04523  670 ESKTKIDDIIELMK 683
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
363-948 2.10e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 72.40  E-value: 2.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  363 VERDLDREDAQNQALQLQKNINELKARIVELESALdnerKKTEELQCSIDEAqfcGDELNAQSQVYKE---KIHDLESKI 439
Cdd:PRK03918  151 VRQILGLDDYENAYKNLGEVIKEIKRRIERLEKFI----KRTENIEELIKEK---EKELEEVLREINEissELPELREEL 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  440 TKLVSATPSLQSI--LPPDLPSDDGALQEEIAKLQEKMtiqqKEVESRIAEQLEEEQRLRENVKYLNEqiatlQSELVSK 517
Cdd:PRK03918  224 EKLEKEVKELEELkeEIEELEKELESLEGSKRKLEEKI----RELEERIEELKKEIEELEEKVKELKE-----LKEKAEE 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  518 DEALEKFslsecgienlrrelellkeenekqaqeaQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLEServnktdecei 597
Cdd:PRK03918  295 YIKLSEF----------------------------YEEYLDELREIEKRLSRLEEEINGIEERIKELEE----------- 335

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  598 lqtevrmRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTL----LEKTEKELVQSKEQAAKTLNDKE 673
Cdd:PRK03918  336 -------KEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLtgltPEKLEKELEELEKAKEEIEEEIS 408

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  674 QLEKQISDLKQLAEQEKLV---------------REMTE----NAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVH 734
Cdd:PRK03918  409 KITARIGELKKEIKELKKAieelkkakgkcpvcgRELTEehrkELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKV 488

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  735 LQEIKAQNTQKDF--ELVESGESLKKLQ-QQLEQKTLGHEKLQAALEELKKEKETIIKEKEqELQQLQSKSAESESALKV 811
Cdd:PRK03918  489 LKKESELIKLKELaeQLKELEEKLKKYNlEELEKKAEEYEKLKEKLIKLKGEIKSLKKELE-KLEELKKKLAELEKKLDE 567

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  812 VQVQLEQLQQQAaasGEEGSKTVAKLHDEISQLKSQAEEtQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQIT 891
Cdd:PRK03918  568 LEEELAELLKEL---EELGFESVEELEERLKELEPFYNE-YLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLE 643

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 442628156  892 KLKSEVGETQAALS-SCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKE 948
Cdd:PRK03918  644 ELRKELEELEKKYSeEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKE 701
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 601-963 4.03e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 71.64  E-value: 4.03e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   601 EVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAaktlndkEQLEKQIS 680
Cdd:TIGR02169  675 ELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERL-------EELEEDLS 747

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   681 DLKQlaEQEKLVREMTENAinqiqLEKESIEQQLALKQNELEDFQKKQSESEVhlQEIKAQNTQKDFELVESGESLKKLQ 760
Cdd:TIGR02169  748 SLEQ--EIENVKSELKELE-----ARIEELEEDLHKLEEALNDLEARLSHSRI--PEIQAELSKLEEEVSRIEARLREIE 818

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   761 QQLEQKTLGHEKLQAALEELKKEKETI---IKEKEQELQQLQSKSAESESALkvvqvqleqlqqqaaasgEEGSKTVAKL 837
Cdd:TIGR02169  819 QKLNRLTLEKEYLEKEIQELQEQRIDLkeqIKSIEKEIENLNGKKEELEEEL------------------EELEAALRDL 880

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   838 HDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHT--DVESKT 915
Cdd:TIGR02169  881 ESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSleDVQAEL 960

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 442628156   916 KQLEAANAALEKVN----KEYAESRAEASDLQDKvkeitdtlHAELQAERSS 963
Cdd:TIGR02169  961 QRVEEEIRALEPVNmlaiQEYEEVLKRLDELKEK--------RAKLEEERKA 1004
mukB PRK04863
chromosome partition protein MukB;
1143-1517 4.84e-12

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 71.53  E-value: 4.84e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1143 RLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQElqdsvkqkeelvQNLE 1222
Cdd:PRK04863  283 VHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNLVQTALRQ------------QEKI 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1223 EKVRESssiieaqntkLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEAngdikdslvkveelv 1302
Cdd:PRK04863  351 ERYQAD----------LEELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQLADYQQA--------------- 405

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1303 kvleeklqaatsqLDAQQATNKELQELLVKSQENEGNLQGESLAVT---EKLQQLEQANGELKEALCQKENGLKELQGKL 1379
Cdd:PRK04863  406 -------------LDVQQTRAIQYQQAVQALERAKQLCGLPDLTADnaeDWLEEFQAKEQEATEELLSLEQKLSVAQAAH 472

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1380 DESNTVLESQKKSHNEI--QDKLEQAQQKERTLQEEtSKLAEQLSQLKQANEELQKSLQQKQLLLEkgnefdtQLAEYQK 1457
Cdd:PRK04863  473 SQFEQAYQLVRKIAGEVsrSEAWDVARELLRRLREQ-RHLAEQLQQLRMRLSELEQRLRQQQRAER-------LLAEFCK 544

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1458 VIDEMDDAAsvksALLEQLQnrvAELETALRQANDAQKTAYLETKELRRQLESLELEKSR 1517
Cdd:PRK04863  545 RLGKNLDDE----DELEQLQ---EELEARLESLSESVSEARERRMALRQQLEQLQARIQR 597
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
994-1558 5.03e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 71.25  E-value: 5.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  994 QEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEEsIKNLQEEVTKAKTENLELstgtQTTIKDLQERLEITNAE 1073
Cdd:PRK03918  200 KELEEVLREINEISSELPELREELEKLEKEVKELEELKEE-IEELEKELESLEGSKRKL----EEKIRELEERIEELKKE 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1074 LQHKEKMASE------DAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNhifelfemeadmNSERLIEK 1147
Cdd:PRK03918  275 IEELEEKVKElkelkeKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELE------------EKEERLEE 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1148 VTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESqtskekLTEIQQSLQELQDSVKQKEELVQNLEEKVRE 1227
Cdd:PRK03918  343 LKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLT------PEKLEKELEELEKAKEEIEEEISKITARIGE 416

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1228 SSSIIEAQNTKLNESNVQ-------------------LENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEAN 1288
Cdd:PRK03918  417 LKKEIKELKKAIEELKKAkgkcpvcgrelteehrkelLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELI 496

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1289 gdikdSLVKVEELVKVLEEKLQAAtsQLDAQQATNKELQELLVKSQENEGNLQGESLAVtEKLQQLEQANGELKEALCQK 1368
Cdd:PRK03918  497 -----KLKELAEQLKELEEKLKKY--NLEELEKKAEEYEKLKEKLIKLKGEIKSLKKEL-EKLEELKKKLAELEKKLDEL 568

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1369 ENGLKELQGKLDE----SNTVLESQ--------------KKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEE 1430
Cdd:PRK03918  569 EEELAELLKELEElgfeSVEELEERlkelepfyneylelKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKE 648

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1431 LQkslqqkqlllEKGNEFDTQlaEYQKVIDEMddaasvksallEQLQNRVAELETALRQANDAQKTAYLETKELRRQLES 1510
Cdd:PRK03918  649 LE----------ELEKKYSEE--EYEELREEY-----------LELSRELAGLRAELEELEKRREEIKKTLEKLKEELEE 705

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*...
gi 442628156 1511 LElEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSII 1558
Cdd:PRK03918  706 RE-KAKKELEKLEKALERVEELREKVKKYKALLKERALSKVGEIASEI 752
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 784-1514 5.06e-12

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 71.36  E-value: 5.06e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   784 KETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQqqaaasgEEGSKTVAKLHDEiSQLKSQAEETQSELKSTQSNLE 863
Cdd:pfam01576    3 QEEEMQAKEEELQKVKERQQKAESELKELEKKHQQLC-------EEKNALQEQLQAE-TELCAEAEEMRARLAARKQELE 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   864 AKSKQLEAangSLEEEAKKSGHLL-------EQITKLKSEVGETQAALSSCHTD---VESKTKQLEAANAALEKVNKEYA 933
Cdd:pfam01576   75 EILHELES---RLEEEEERSQQLQnekkkmqQHIQDLEEQLDEEEAARQKLQLEkvtTEAKIKKLEEDILLLEDQNSKLS 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   934 EsraEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAwSQEMLQKEKELQELRQQLQDS 1013
Cdd:pfam01576  152 K---ERKLLEERISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQEL-EKAKRKLEGESTDLQEQIAEL 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1014 QDSQTKLKAEGERKEKSFEESIKNLQEEvTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKT 1093
Cdd:pfam01576  228 QAQIAELRAQLAKKEEELQAALARLEEE-TAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKT 306

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1094 LVEAIQvanaNISATNAELSTVLEvlqaekSETNHIFELFEMEADMNSERLIEKVTGIKEELKETHLQLdERQKKFEELE 1173
Cdd:pfam01576  307 ELEDTL----DTTAAQQELRSKRE------QEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQL-EQAKRNKANL 375

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1174 EKLKQAQQSEQK--------LQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQ 1245
Cdd:pfam01576  376 EKAKQALESENAelqaelrtLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGK 455

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1246 LENKTSCLKETQDQLLESQKkekQLQEEAA---KLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQAT 1322
Cdd:pfam01576  456 NIKLSKDVSSLESQLQDTQE---LLQEETRqklNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKK 532

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1323 NKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELkealcqkENGLKELQGKLDESNTVLESQKkshnEIQDKLEQ 1402
Cdd:pfam01576  533 LEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKL-------EKTKNRLQQELDDLLVDLDHQR----QLVSNLEK 601

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1403 AQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKgnefdtQLAEYQKVIDEMDDAASVKSALLEQLQNRVAE 1482
Cdd:pfam01576  602 KQKKFDQMLAEEKAISARYAEERDRAEAEAREKETRALSLAR------ALEEALEAKEELERTNKQLRAEMEDLVSSKDD 675

                          730       740       750
                   ....*....|....*....|....*....|..
gi 442628156  1483 LETALRQANDAQKTAYLETKELRRQLESLELE 1514
Cdd:pfam01576  676 VGKNVHELERSKRALEQQVEEMKTQLEELEDE 707
PTZ00121 PTZ00121
MAEBL; Provisional
 916-1534 8.41e-12

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 70.56  E-value: 8.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  916 KQLEAANAAlEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIAT--GHKELTSKAD-AW 992
Cdd:PTZ00121 1200 RKAEAARKA-EEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAhfARRQAAIKAEeAR 1278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  993 SQEMLQKEKELQ---ELRQQLQDSQDSQTKLKAEGERKE---KSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQER 1066
Cdd:PTZ00121 1279 KADELKKAEEKKkadEAKKAEEKKKADEAKKKAEEAKKAdeaKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADE 1358

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1067 LEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAE---------KSETNHIFELFEMEA 1137
Cdd:PTZ00121 1359 AEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAaakkkadeaKKKAEEKKKADEAKK 1438

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1138 DMNSERLIEKVTGIKEELK--ETHLQLDERQKKFEELEEKLKQAQQSEQkLQQESQTSKEKLTEIQQSLQELQ--DSVKQ 1213
Cdd:PTZ00121 1439 KAEEAKKADEAKKKAEEAKkaEEAKKKAEEAKKADEAKKKAEEAKKADE-AKKKAEEAKKKADEAKKAAEAKKkaDEAKK 1517

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1214 KEELVQNLE-EKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIK 1292
Cdd:PTZ00121 1518 AEEAKKADEaKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEV 1597

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1293 DSLVKVEELVKVlEEKLQAATSQLDAQQATNKELQEllvKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKEngl 1372
Cdd:PTZ00121 1598 MKLYEEEKKMKA-EEAKKAEEAKIKAEELKKAEEEK---KKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKA--- 1670

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1373 KELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKE--RTLQEETSKLAEQL-----------SQLKQANEELQKSLQQKQ 1439
Cdd:PTZ00121 1671 EEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEelKKKEAEEKKKAEELkkaeeenkikaEEAKKEAEEDKKKAEEAK 1750

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1440 LLLEKGNEFDTQLAEYQKVIDEM--DDAASVKSALLEQLQNRVAELETALRQA------------------NDAQKTAYL 1499
Cdd:PTZ00121 1751 KDEEEKKKIAHLKKEEEKKAEEIrkEKEAVIEEELDEEDEKRRMEVDKKIKDIfdnfaniieggkegnlviNDSKEMEDS 1830

                         650       660       670
                  ....*....|....*....|....*....|....*
gi 442628156 1500 ETKELRRQlESLELEKSREVLSLKAQMNGASSRSG 1534
Cdd:PTZ00121 1831 AIKEVADS-KNMQLEEADAFEKHKFNKNNENGEDG 1864
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 707-1439 8.80e-12

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 70.53  E-value: 8.80e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   707 KESIEQQLALKQNELEDFQKKQSES-EVH-----------------LQEIKAQ-NTQKDFELVESgESLKKLQQQLEQKT 767
Cdd:pfam15921   73 KEHIERVLEEYSHQVKDLQRRLNESnELHekqkfylrqsvidlqtkLQEMQMErDAMADIRRRES-QSQEDLRNQLQNTV 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   768 LGHEKLQAALEELKKEKETIIKE-------KEQELQQLQSKSAESESAL-KVVQVQLEQLQQQAAASGEEGSKTVAKLHD 839
Cdd:pfam15921  152 HELEAAKCLKEDMLEDSNTQIEQlrkmmlsHEGVLQEIRSILVDFEEASgKKIYEHDSMSTMHFRSLGSAISKILRELDT 231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   840 EISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAkKSGHLLEqITKLKSEVGETQAALSSCHTDVESKTKQLE 919
Cdd:pfam15921  232 EISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQL-ISEHEVE-ITGLTEKASSARSQANSIQSQLEIIQEQAR 309

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   920 AANAAL--------EKVNKEYAESRAEASDLQDKVKEITDTL---HAELQAERS-------SSSALHTKLSKFSDEIATG 981
Cdd:pfam15921  310 NQNSMYmrqlsdleSTVSQLRSELREAKRMYEDKIEELEKQLvlaNSELTEARTerdqfsqESGNLDDQLQKLLADLHKR 389

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   982 HKELTSKADA----WSQEM---LQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQeevtkAKTENLELST 1054
Cdd:pfam15921  390 EKELSLEKEQnkrlWDRDTgnsITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQ-----GKNESLEKVS 464

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1055 GTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVE----AIQVANANISATNAELSTVLEVLQAEKSETNHIf 1130
Cdd:pfam15921  465 SLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQekerAIEATNAEITKLRSRVDLKLQELQHLKNEGDHL- 543

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1131 elfemeadmnserliekvTGIKEELKETHLQLDERQKKFEELEEKLKQAQQ-------SEQKLQQESQTSKEKLTEIQQS 1203
Cdd:pfam15921  544 ------------------RNVQTECEALKLQMAEKDKVIEILRQQIENMTQlvgqhgrTAGAMQVEKAQLEKEINDRRLE 605

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1204 LQELQDSVKQKEELVQNLEEKVressSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQlqeEAAKLSGELQQ 1283
Cdd:pfam15921  606 LQEFKILKDKKDAKIRELEARV----SDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRN---ELNSLSEDYEV 678

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1284 VQEangDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQ-------ELLVKSQENEGNLQGESLAVTEKLQQLEQ 1356
Cdd:pfam15921  679 LKR---NFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEgsdghamKVAMGMQKQITAKRGQIDALQSKIQFLEE 755

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1357 ANGELKealcQKENGLKELQGKLDESNTVLESQKkshNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQ 1436
Cdd:pfam15921  756 AMTNAN----KEKHFLKEEKNKLSQELSTVATEK---NKMAGELEVLRSQERRLKEKVANMEVALDKASLQFAECQDIIQ 828


                   ...
gi 442628156  1437 QKQ 1439
Cdd:pfam15921  829 RQE 831
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1110-1571 1.06e-11

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 70.07  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1110 AELSTVLEVLQAEKSETNHIFELFEMEADMNSERLiEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQE 1189
Cdd:PRK02224  202 KDLHERLNGLESELAELDEEIERYEEQREQARETR-DEADEVLEEHEERREELETLEAEIEDLRETIAETEREREELAEE 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1190 SQTSKEKLTEIQQSLQEL----------QDSVKQKEELVQNLEEKVRESssiIEAQNTKLNESNVQLENktscLKETQDQ 1259
Cdd:PRK02224  281 VRDLRERLEELEEERDDLlaeaglddadAEAVEARREELEDRDEELRDR---LEECRVAAQAHNEEAES----LREDADD 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1260 LlESQKKEkqLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQEllvksqenegn 1339
Cdd:PRK02224  354 L-EERAEE--LREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELRE----------- 419

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1340 lqgESLAVTEKLQQLEqanGELKEAlcqkENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAE 1419
Cdd:PRK02224  420 ---ERDELREREAELE---ATLRTA----RERVEEAEALLEAGKCPECGQPVEGSPHVETIEEDRERVEELEAELEDLEE 489

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1420 QLSQLKQ---ANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAAsvksallEQLQNRVAELETALRQANDAQKT 1496
Cdd:PRK02224  490 EVEEVEErleRAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERA-------EELRERAAELEAEAEEKREAAAE 562

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442628156 1497 AYLETKELRRQLESLEleksrevlslkaqmngaSSRSGKGDEVESLD-IETSLAKINFLNSIIADMQQKNDALKAK 1571
Cdd:PRK02224  563 AEEEAEEAREEVAELN-----------------SKLAELKERIESLErIRTLLAAIADAEDEIERLREKREALAEL 621
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1234-1494 1.55e-11

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 68.25  E-value: 1.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1234 AQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAAT 1313
Cdd:COG4942    17 AQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1314 SQLDAQQatnKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEalcqkenglkelqgkldesntVLESQKKSH 1393
Cdd:COG4942    97 AELEAQK---EELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKY---------------------LAPARREQA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1394 NEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLekgNEFDTQLAEYQKVIDEMDDAASVKSALL 1473
Cdd:COG4942   153 EELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLL---ARLEKELAELAAELAELQQEAEELEALI 229

                         250       260
                  ....*....|....*....|.
gi 442628156 1474 EQLQNRVAELETALRQANDAQ 1494
Cdd:COG4942   230 ARLEAEAAAAAERTPAAGFAA 250
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1305-1532 1.92e-11

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 68.89  E-value: 1.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1305 LEEKLQAATSQLDAQQAtnkELQELlvKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNT 1384
Cdd:COG3206   180 LEEQLPELRKELEEAEA---ALEEF--RQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPD 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1385 VLESQKKShNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQlllekgnefdtqlAEYQKVIDEMDD 1464
Cdd:COG3206   255 ALPELLQS-PVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQ-------------QEAQRILASLEA 320

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442628156 1465 AASVKSALLEQLQNRVAELETALRQANDAQKtaylETKELRRQLESLE-----LEKSREVLSLKAQMNGASSR 1532
Cdd:COG3206   321 ELEALQAREASLQAQLAQLEARLAELPELEA----ELRRLEREVEVARelyesLLQRLEEARLAEALTVGNVR 389
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 348-1042 2.17e-11

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 69.33  E-value: 2.17e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   348 QDLLREKQQHVEKLMVERDldrEDAQNQALQLQKNINELKARIVELESA---LDNERKKTEELQCSIDEAQFCGDELNAQ 424
Cdd:TIGR02169  190 DLIIDEKRQQLERLRRERE---KAERYQALLKEKREYEGYELLKEKEALerqKEAIERQLASLEEELEKLTEEISELEKR 266

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   425 SQVYKEKIHDLESKITKLVSatpslqsilppdlpsddgalqEEIAKLQEKM---TIQQKEVESRIAEQLEEEQRLRENVK 501
Cdd:TIGR02169  267 LEEIEQLLEELNKKIKDLGE---------------------EEQLRVKEKIgelEAEIASLERSIAEKERELEDAEERLA 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   502 YLNEQIATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFT---RKLAEKSVEVLRLSSELQNLK 578
Cdd:TIGR02169  326 KLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAetrDELKDYREKLEKLKREINELK 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   579 ATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKEL 658
Cdd:TIGR02169  406 RELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKEL 485

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   659 VQSKEQAAKTLNDKEQLEK---------------------QISDLKQLAEQEKLVREMTE-NAINQIQLEKESIEQQLA- 715
Cdd:TIGR02169  486 SKLQRELAEAEAQARASEErvrggraveevlkasiqgvhgTVAQLGSVGERYATAIEVAAgNRLNNVVVEDDAVAKEAIe 565

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   716 -LKQ-----------NELEDFQKKQSESE--------VHLQEI--KAQNTQK----DFELVESGESLKKLQQQLEQKTL- 768
Cdd:TIGR02169  566 lLKRrkagratflplNKMRDERRDLSILSedgvigfaVDLVEFdpKYEPAFKyvfgDTLVVEDIEAARRLMGKYRMVTLe 645

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   769 ------------GH-----------------EKLQAALEELKKEKETIIKEK---EQELQQLQSKSAESESALKVVQVQL 816
Cdd:TIGR02169  646 gelfeksgamtgGSraprggilfsrsepaelQRLRERLEGLKRELSSLQSELrriENRLDELSQELSDASRKIGEIEKEI 725

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   817 EQLQQQAAASGEEgsktVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEE-EAKKSGHLLEQITKLKS 895
Cdd:TIGR02169  726 EQLEQEEEKLKER----LEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDlEARLSHSRIPEIQAELS 801

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   896 EVGETQAALSSCHTDVESKTKQLEAANAALEKvnkEYAESRAEASDLQDKVKEITDTLHaELQAERSSSSALHTKLSKFS 975
Cdd:TIGR02169  802 KLEEEVSRIEARLREIEQKLNRLTLEKEYLEK---EIQELQEQRIDLKEQIKSIEKEIE-NLNGKKEELEEELEELEAAL 877

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   976 DEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKE---KSFEESIKNLQEEV 1042
Cdd:TIGR02169  878 RDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEeelSEIEDPKGEDEEIP 947
NIP100 COG5244
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ...
 216-793 2.88e-11

Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227569 [Multi-domain]  Cd Length: 669  Bit Score: 68.56  E-value: 2.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  216 MAVGDRVIVSSGFGsrpgILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFV--------------- 280
Cdd:COG5244     4 LSVNDRVLLGDKFG----TVRFIGKTKFKDGIWIGLELDDPVGKNDGSVNGVRYFHCKKRHGIFIrpdddsllngnaaye 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  281 --------------PIAKVSLSPSSKKTRLSRTGSRESLTSIGTMNSIATTA---TSRMRMN------AQRKSSTPVKPI 337
Cdd:COG5244    80 kikgglvceskgmdKDGEIKQENHEDRIHFEESKIRRLEETIEALKSTEKEEiveLRRENEEldkinlSLRERISSEEPE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  338 LATPKSQFSMQDL--LREKQQHVEKLMVERDLDREDAQNQALQLQKNI--NELKARIVE--------LESALDNERKKTE 405
Cdd:COG5244   160 LNKDGSKLSYDELkeFVEESRVQVYDMVELVSDISETLNRNGSIQRSSvrECERSNIHDvlflvngiLDGVIDELNGELE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  406 ELQ---CSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLvsATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQkeV 482
Cdd:COG5244   240 RLRrqlVSLMSSHGIEVEENSRLKATLEKFQSLELKVNTL--QEELYQNKLLKKFYQIYEPFAQAALSSQLQYLAEV--I 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  483 ESRIAEQLEeeqrlrenvkylNEQIATLQSELVSKDEALEKFSLSECgiENLRRELELLKEENEKQAQEAQAEFTRKLAE 562
Cdd:COG5244   316 ESENFGKLE------------NIEIHIILKVLSSISYALHIYTIKNT--PDHLETTLQCFVNIAPISMWLSEFLQRKFSS 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  563 KSVEVLrlsSELQNLKATSDSLE----------------------SERVNKTDECEILQTEVRMRdeQIRELNQQlDEVT 620
Cdd:COG5244   382 KQETAF---SICQFLEDNKDVTLilkilhpilettvpkllaflrtNSNFNDNDTLCLIGSLYEIA--RIDKLIGK-EEIS 455

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  621 TQLN----VQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMT 696
Cdd:COG5244   456 KQDNrlflYPSCDITLSSILTILFSDKLEVFFQGIESLLENITIFPEQPSQQTSDSENIKENSLLSDRLNEENIRLKEVL 535

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  697 ENAINQIQLEKESieQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHE---KL 773
Cdd:COG5244   536 VQKENMLTEETKI--KIIIGRDLERKTLEENIKTLKVELNNKNNKLKEENFNLVNRLKNMELKLYQIKDNNTLNKiylDL 613

                         650       660
                  ....*....|....*....|
gi 442628156  774 QAALEELKKEKETIIKEKEQ 793
Cdd:COG5244   614 VSEIMELRETIRRQIKEQKR 633
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1257-1497 3.07e-11

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 67.10  E-value: 3.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1257 QDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLdaqQATNKELQELLVKSQEN 1336
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQEL---AALEAELAELEKEIAEL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1337 EGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSK 1416
Cdd:COG4942    96 RAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAE 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1417 LAEQLSQLKQANEELQKSLQQKQLLLekgNEFDTQLAEYQKVIDEMDDAAsvksallEQLQNRVAELETALRQANDAQKT 1496
Cdd:COG4942   176 LEALLAELEEERAALEALKAERQKLL---ARLEKELAELAAELAELQQEA-------EELEALIARLEAEAAAAAERTPA 245


                  .
gi 442628156 1497 A 1497
Cdd:COG4942   246 A 246
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
493-1048 3.23e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 68.55  E-value: 3.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  493 EQRLRENVKYLNEQIatlqselvskdEALEKFSLSECGIENLRRELELLKEENEKQAQeaqaEFTRKLAEKSVEVLRLSS 572
Cdd:PRK03918  164 YKNLGEVIKEIKRRI-----------ERLEKFIKRTENIEELIKEKEKELEEVLREIN----EISSELPELREELEKLEK 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  573 ELQNLKATSDSLESERVnktdECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDmLRLQKEGTEEKSTLLE 652
Cdd:PRK03918  229 EVKELEELKEEIEELEK----ELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKE-LKEKAEEYIKLSEFYE 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  653 KTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIE--QQLALKQNELEDFQKKQSE 730
Cdd:PRK03918  304 EYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHElyEEAKAKKEELERLKKRLTG 383

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  731 SEVHLQEIKAQNTQKDFELVEsgESLKKLQQQLEQKTLGHEKLQAALEELKK---------------EKETIIKEKEQEL 795
Cdd:PRK03918  384 LTPEKLEKELEELEKAKEEIE--EEISKITARIGELKKEIKELKKAIEELKKakgkcpvcgrelteeHRKELLEEYTAEL 461

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  796 QQLQSKSAESESALKVVQVQLEQLQQQAaasgeEGSKTVAKLHDEISQLKSQAEETQS------ELKSTQ-SNLEAKSKQ 868
Cdd:PRK03918  462 KRIEKELKEIEEKERKLRKELRELEKVL-----KKESELIKLKELAEQLKELEEKLKKynleelEKKAEEyEKLKEKLIK 536

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  869 LEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESK----TKQLEAANAALEKVNKEYAESRAEASDLQD 944
Cdd:PRK03918  537 LKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELgfesVEELEERLKELEPFYNEYLELKDAEKELER 616

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  945 KVKEITDT----------LHAELQAERSSSSALHTKLSKFSDEiatGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQ 1014
Cdd:PRK03918  617 EEKELKKLeeeldkafeeLAETEKRLEELRKELEELEKKYSEE---EYEELREEYLELSRELAGLRAELEELEKRREEIK 693

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|...
gi 442628156 1015 DSQTKLKAEGERKEKSFEES---------IKNLQEEVTKAKTE 1048
Cdd:PRK03918  694 KTLEKLKEELEEREKAKKELeklekalerVEELREKVKKYKAL 736
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 1161-1436 3.87e-11

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 67.74  E-value: 3.87e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1161 QLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEK--LTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTK 1238
Cdd:pfam05667  215 ELAAAQEWEEEWNSQGLASRLTPEEYRKRKRTKLLKriAEQLRSAALAGTEATSGASRSAQDLAELLSSFSGSSTTDTGL 294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1239 LNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDA 1318
Cdd:pfam05667  295 TKGSRFTHTEKLQFTNEAPAATSSPPTKVETEEELQQQREEELEELQEQLEDLESSIQELEKEIKKLESSIKQVEEELEE 374

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1319 QQATNKELQE----------LLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQ-GKLDESNTVLE 1387
Cdd:pfam05667  375 LKEQNEELEKqykvkkktldLLPDAEENIAKLQALVDASAQRLVELAGQWEKHRVPLIEEYRALKEAKsNKEDESQRKLE 454

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442628156  1388 SQKKSHNEIQDKLEQAQQKE---RTLQEE-------------TSKLAEQLSQLKQANEELQKSLQ 1436
Cdd:pfam05667  455 EIKELREKIKEVAEEAKQKEelyKQLVAEyerlpkdvsrsayTRRILEIVKNIKKQKEEITKILS 519
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 837-1461 5.01e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 67.74  E-value: 5.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   837 LHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTK 916
Cdd:TIGR04523   73 SNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEK 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   917 QLEAANAALEKVNKEYAESRAE----ASDLQDKVKEITDTLHAELQAERSSSS-----ALHTKLSKFSDEIATGHKELTS 987
Cdd:TIGR04523  153 ELEKLNNKYNDLKKQKEELENElnllEKEKLNIQKNIDKIKNKLLKLELLLSNlkkkiQKNKSLESQISELKKQNNQLKD 232

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   988 KADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEES---IKNLQEEVTKAKTENLEL-STGTQTTIKDL 1063
Cdd:TIGR04523  233 NIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNnkkIKELEKQLNQLKSEISDLnNQKEQDWNKEL 312

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1064 QERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEvlqaeksETNHIFELFEMEADMNSER 1143
Cdd:TIGR04523  313 KSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELE-------EKQNEIEKLKKENQSYKQE 385

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1144 lIEKVTGIKEELKethLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEe 1223
Cdd:TIGR04523  386 -IKNLESQINDLE---SKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLD- 460

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1224 kvressSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSgelQQVQEANGDIKDSLVKVEELVK 1303
Cdd:TIGR04523  461 ------NTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELE---EKVKDLTKKISSLKEKIEKLES 531

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1304 VLEEKlqaatsqldAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESN 1383
Cdd:TIGR04523  532 EKKEK---------ESKISDLEDELNKDDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLI 602

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442628156  1384 tvlesqkkshNEIQDKLEQAQQKERtlqeetsklaeqlsQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDE 1461
Cdd:TIGR04523  603 ----------KEIEEKEKKISSLEK--------------ELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKE 656
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1187-1427 5.42e-11

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 66.33  E-value: 5.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1187 QQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKK 1266
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1267 EKQLQEEAAKLSGELQQVQEANGDI----KDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLvksqenegnlqg 1342
Cdd:COG4942    99 LEAQKEELAELLRALYRLGRQPPLAlllsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALR------------ 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1343 eslavteklQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLS 1422
Cdd:COG4942   167 ---------AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAA 237


                  ....*
gi 442628156 1423 QLKQA 1427
Cdd:COG4942   238 AAAER 242
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 352-1250 6.20e-11

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 67.76  E-value: 6.20e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   352 REKQQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQcSIDEAQFCGDELNAQsqvykek 431
Cdd:TIGR00606  216 KEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIK-ALKSRKKQMEKDNSE------- 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   432 ihdLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQ---EKMTIQQKEVESRIAEQLEEEQRLRENVKYLNEQIA 508
Cdd:TIGR00606  288 ---LELKMEKVFQGTDEQLNDLYHNHQRTVREKERELVDCQrelEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHIR 364

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   509 TLQSELVSKD-----EALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDs 583
Cdd:TIGR00606  365 ARDSLIQSLAtrlelDGFERGPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIE- 443

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   584 LESERVNKTDE------CEILQTEVRMRDeqIRELNQQLDEVTTQLNvqKADSSALDDMLRLQKEGTEEKSTLLEKTEKE 657
Cdd:TIGR00606  444 LKKEILEKKQEelkfviKELQQLEGSSDR--ILELDQELRKAERELS--KAEKNSLTETLKKEVKSLQNEKADLDRKLRK 519

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   658 LVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLE---KESIEQQLALKQNELEDFQKKQSESEVH 734
Cdd:TIGR00606  520 LDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYfpnKKQLEDWLHSKSKEINQTRDRLAKLNKE 599

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   735 LQEIKAQNTQKDFELVESGESLKKLQQQLEQkTLGHEKLQAALEELKKEketiIKEKEQELQQLQSKSAESESALKVVQV 814
Cdd:TIGR00606  600 LASLEQNKNHINNELESKEEQLSSYEDKLFD-VCGSQDEESDLERLKEE----IEKSSKQRAMLAGATAVYSQFITQLTD 674

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   815 QLEQLQQQAaasgEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLK 894
Cdd:TIGR00606  675 ENQSCCPVC----QRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELR 750

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   895 SEVGETQAALSSCHTDVESKTKQLEAANAAlEKVNKEYAESRAEASDLQDKVKEITDTLhaELQAERSSSSALHTKLSKF 974
Cdd:TIGR00606  751 NKLQKVNRDIQRLKNDIEEQETLLGTIMPE-EESAKVCLTDVTIMERFQMELKDVERKI--AQQAAKLQGSDLDRTVQQV 827

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   975 SDEIATGHKEL---TSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERK---EKSFEESIKNLQEEVTKAKTE 1048
Cdd:TIGR00606  828 NQEKQEKQHELdtvVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRqqfEEQLVELSTEVQSLIREIKDA 907

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1049 NLELSTGTQTTIKDLQERLEITNAELQHKEK-------MASEDAQKIADLKTLVEAIQVANAN-ISATNAELSTVLEVLQ 1120
Cdd:TIGR00606  908 KEQDSPLETFLEKDQQEKEELISSKETSNKKaqdkvndIKEKVKNIHGYMKDIENKIQDGKDDyLKQKETELNTVNAQLE 987

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1121 AEKSETNHIfelfemEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLK------------QAQQSEQKLQQ 1188
Cdd:TIGR00606  988 ECEKHQEKI------NEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEELKqhlkemgqmqvlQMKQEHQKLEE 1061

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442628156  1189 ESQTSKEKLTEIQQSLQELQDSVKQ-----KEELVQNLEEKVREssSIIEAQNTKLNESNVQLENKT 1250
Cdd:TIGR00606 1062 NIDLIKRNHVLALGRQKGYEKEIKHfkkelREPQFRDAEEKYRE--MMIVMRTTELVNKDLDIYYKT 1126
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 698-1435 8.64e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 66.97  E-value: 8.64e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   698 NAINQIQLEKESIEQQLALKQNELEDFQKKqsesevhlqeikaqntqkdfelvesgesLKKLQQQLEQKtlgheklqaal 777
Cdd:TIGR04523   26 NIANKQDTEEKQLEKKLKTIKNELKNKEKE----------------------------LKNLDKNLNKD----------- 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   778 EELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSktvaKLHDEISQLKSQAEETQSELKS 857
Cdd:TIGR04523   67 EEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKN----KLEVELNKLEKQKKENKKNIDK 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   858 TQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALsschTDVESKTKQLEAANAALEKVNKEYAESRA 937
Cdd:TIGR04523  143 FLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNI----DKIKNKLLKLELLLSNLKKKIQKNKSLES 218

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   938 EASDLQDKVKEITDTlhaeLQAERSSSSALHTKLSKFSDEIatghKELTSKADAWSQEMLQKEKELQelrqqlqdsqdsq 1017
Cdd:TIGR04523  219 QISELKKQNNQLKDN----IEKKQQEINEKTTEISNTQTQL----NQLKDEQNKIKKQLSEKQKELE------------- 277

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1018 tklkaEGERKEKSFEESIKNLQEEVTKAKTE-NLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVE 1096
Cdd:TIGR04523  278 -----QNNKKIKELEKQLNQLKSEISDLNNQkEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELT 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1097 AIQVANANISATNAELSTVLEVLQAEKSETNhifelfemeadmnserliEKVTGIKEELKETHLQLDERQKKFEELEEKL 1176
Cdd:TIGR04523  353 NSESENSEKQRELEEKQNEIEKLKKENQSYK------------------QEIKNLESQINDLESKIQNQEKLNQQKDEQI 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1177 KQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEekvressSIIEAQNTKLNESNVQLENKTSCLKET 1256
Cdd:TIGR04523  415 KKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLD-------NTRESLETQLKVLSRSINKIKQNLEQK 487

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1257 QDQLLESQKKEKQLQEEAAKLSgelQQVQEANGDIKDSLVKVEELVKVLEEKlqaatsqldAQQATNKELQELLVKSQEN 1336
Cdd:TIGR04523  488 QKELKSKEKELKKLNEEKKELE---EKVKDLTKKISSLKEKIEKLESEKKEK---------ESKISDLEDELNKDDFELK 555

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1337 EGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSK 1416
Cdd:TIGR04523  556 KENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKN 635

                          730
                   ....*....|....*....
gi 442628156  1417 LAEQLSQLKQANEELQKSL 1435
Cdd:TIGR04523  636 IKSKKNKLKQEVKQIKETI 654
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1350-1578 9.81e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 66.88  E-value: 9.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1350 KLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLS----QLK 1425
Cdd:COG1196   233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIArleeRRR 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1426 QANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELR 1505
Cdd:COG1196   313 ELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEAL 392

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442628156 1506 RQLESLELEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQKNDALKAKVQTLETL 1578
Cdd:COG1196   393 RAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELL 465
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
360-980 1.15e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 66.60  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  360 KLMVERDLDreDAQNQALQLQKNINE-----LKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHD 434
Cdd:PRK02224  175 RLGVERVLS--DQRGSLDQLKAQIEEkeekdLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREE 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  435 LESkitklvsatpslqsilppdlpsddgaLQEEIAKLQEKmtiqqkevesrIAEQLEEEQRLRENVKYLNEQIATLQSEL 514
Cdd:PRK02224  253 LET--------------------------LEAEIEDLRET-----------IAETEREREELAEEVRDLRERLEELEEER 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  515 vskDEALEKFSLSECGIEnlrrelelLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDE 594
Cdd:PRK02224  296 ---DDLLAEAGLDDADAE--------AVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREE 364

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  595 CEILQTE-------VRMRDEQIRELNQQLDEVTTQLN---VQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQ 664
Cdd:PRK02224  365 AAELESEleeareaVEDRREEIEELEEEIEELRERFGdapVDLGNAEDFLEELREERDELREREAELEATLRTARERVEE 444

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  665 AAKTLNdkeqlEKQISDLKQLAEQEKLVREMTENainqiqlekesiEQQLALKQNELEDFQKKQSESEvhlqeikaqntq 744
Cdd:PRK02224  445 AEALLE-----AGKCPECGQPVEGSPHVETIEED------------RERVEELEAELEDLEEEVEEVE------------ 495

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  745 kdfELVESGESLKKLQQQLEQKtlghEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESAlkvvQVQLEQLQQQAA 824
Cdd:PRK02224  496 ---ERLERAEDLVEAEDRIERL----EERREDLEELIAERRETIEEKRERAEELRERAAELEAE----AEEKREAAAEAE 564

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  825 ASGEEGSKTVAKLHDEISQLKSQAE------ETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVG 898
Cdd:PRK02224  565 EEAEEAREEVAELNSKLAELKERIEslerirTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEFD 644

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  899 ETQaalsschtdVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLH--AELQAERSSSSALHTKLSKFSD 976
Cdd:PRK02224  645 EAR---------IEEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEelEELRERREALENRVEALEALYD 715


                  ....
gi 442628156  977 EIAT 980
Cdd:PRK02224  716 EAEE 719
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1132-1443 1.25e-10

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 66.01  E-value: 1.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1132 LFEMEADMNSERLIEkvtgIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSV 1211
Cdd:PRK04778   88 LFEAEELNDKFRFRK----AKHEINEIESLLDLIEEDIEQILEELQELLESEEKNREEVEQLKDLYRELRKSLLANRFSF 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1212 --------KQKEELVQNLEEKVRESSS--IIEAQNT--KLNESNVQLENKT--------SCLKETQDQLLESQKKEKQLQ 1271
Cdd:PRK04778  164 gpaldeleKQLENLEEEFSQFVELTESgdYVEAREIldQLEEELAALEQIMeeipellkELQTELPDQLQELKAGYRELV 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1272 EE-----AAKLSGELQQVQEAngdIKDSLVKVEEL-VKVLEEKLQAATSQLD-----------AQQ---ATNKELQELLV 1331
Cdd:PRK04778  244 EEgyhldHLDIEKEIQDLKEQ---IDENLALLEELdLDEAEEKNEEIQERIDqlydilerevkARKyveKNSDTLPDFLE 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1332 KSQENEGNLQGEslavTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQ 1411
Cdd:PRK04778  321 HAKEQNKELKEE----IDRVKQSYTLNESELESVRQLEKQLESLEKQYDEITERIAEQEIAYSELQEELEEILKQLEEIE 396

                         330       340       350
                  ....*....|....*....|....*....|..
gi 442628156 1412 EETSKLAEQLSQLKQANEELQKSLQQKQLLLE 1443
Cdd:PRK04778  397 KEQEKLSEMLQGLRKDELEAREKLERYRNKLH 428
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1144-1512 1.29e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 66.63  E-value: 1.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1144 LIEKVTGIKE--ELKETHL-QLDERQKKFEELEEKLKQAQQSEQKLQQESQTsKEKLTEIQQSLQELQDSVKQKEElvqn 1220
Cdd:TIGR02169  158 IIDEIAGVAEfdRKKEKALeELEEVEENIERLDLIIDEKRQQLERLRREREK-AERYQALLKEKREYEGYELLKEK---- 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1221 leEKVRESSSIIEAQNTKLNESNVQLEnktsclKETQDQLLESQKKEKQLQEEAAKL----SGELQQVQEANGDIKDSLV 1296
Cdd:TIGR02169  233 --EALERQKEAIERQLASLEEELEKLT------EEISELEKRLEEIEQLLEELNKKIkdlgEEEQLRVKEKIGELEAEIA 304

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1297 KVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQ 1376
Cdd:TIGR02169  305 SLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETR 384

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1377 GKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGnefDTQLAEYQ 1456
Cdd:TIGR02169  385 DELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQ---EWKLEQLA 461

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 442628156  1457 KVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLE 1512
Cdd:TIGR02169  462 ADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLK 517
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1153-1365 1.36e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 65.17  E-value: 1.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1153 EELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSII 1232
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1233 EAQNTKLNESNVQLEnKTSclKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAA 1312
Cdd:COG4942   100 EAQKEELAELLRALY-RLG--RQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAEL 176

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 442628156 1313 TSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEAL 1365
Cdd:COG4942   177 EALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALI 229
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
940-1578 1.73e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 66.22  E-value: 1.73e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  940 SDLQDKVKEITDT-LHAELQAERSSSSALHTKLSKFSDEIATGhKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSqt 1018
Cdd:PRK02224  190 DQLKAQIEEKEEKdLHERLNGLESELAELDEEIERYEEQREQA-RETRDEADEVLEEHEERREELETLEAEIEDLRET-- 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1019 klKAEGERKEKSFEESIKNLQEEVTKAKTEN------LELSTGTQTTIKDLQERLEITNAELQhkekmasedaqkiadlk 1092
Cdd:PRK02224  267 --IAETEREREELAEEVRDLRERLEELEEERddllaeAGLDDADAEAVEARREELEDRDEELR----------------- 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1093 tlvEAIQVANANISATNAELSTVLEvlQAEKSETNhifelfemeadmnSERLIEKVTGIKEELKETHLQLDERQKKFEEL 1172
Cdd:PRK02224  328 ---DRLEECRVAAQAHNEEAESLRE--DADDLEER-------------AEELREEAAELESELEEAREAVEDRREEIEEL 389

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1173 EEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSC 1252
Cdd:PRK02224  390 EEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGKCPECGQPVEGSPHVET 469

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1253 LKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEangdikdsLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVK 1332
Cdd:PRK02224  470 IEEDRERVEELEAELEDLEEEVEEVEERLERAED--------LVEAEDRIERLEERREDLEELIAERRETIEEKRERAEE 541

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1333 SQENEGNLQGESLAVTEKLQQLEQANGELKEALcqkenglKELQGKLDESNTVLESQkkshNEIQDKLEQAQQKERTLQE 1412
Cdd:PRK02224  542 LRERAAELEAEAEEKREAAAEAEEEAEEAREEV-------AELNSKLAELKERIESL----ERIRTLLAAIADAEDEIER 610

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1413 etskLAEQLSQLKQANEELQKSLQQKqlllekgNEFDTQLAEyqkvidEMDDAAsvksalLEQLQNRVAELETALRQAND 1492
Cdd:PRK02224  611 ----LREKREALAELNDERRERLAEK-------RERKRELEA------EFDEAR------IEEAREDKERAEEYLEQVEE 667

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1493 aqktaylETKELRRQLESLEleksrevlslkAQMNGASSrsgkgdEVESLDietslakinflnsiiaDMQQKNDALKAKV 1572
Cdd:PRK02224  668 -------KLDELREERDDLQ-----------AEIGAVEN------ELEELE----------------ELRERREALENRV 707


                  ....*.
gi 442628156 1573 QTLETL 1578
Cdd:PRK02224  708 EALEAL 713
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 362-783 1.88e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 66.23  E-value: 1.88e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   362 MVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHDLESKITK 441
Cdd:TIGR02168  672 ILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQ 751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   442 lvsatpslqsilppdlpsddgaLQEEIAKLQEKMTiqqkEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEAL 521
Cdd:TIGR02168  752 ----------------------LSKELTELEAEIE----ELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREAL 805

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   522 EKFS--LSECGIENLRRELELLKEENEKQAQEAQAEFTRK-LAEKSVEVLRLSSELQNLKATSDSLESERvnktdecEIL 598
Cdd:TIGR02168  806 DELRaeLTLLNEEAANLRERLESLERRIAATERRLEDLEEqIEELSEDIESLAAEIEELEELIEELESEL-------EAL 878

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   599 QTEVRMRDEQIRELNQQLDEVTTQLNvqkadsSALDDMLRLQKEgteekstlLEKTEKELVQSKEQAAKTLNDKEQLekq 678
Cdd:TIGR02168  879 LNERASLEEALALLRSELEELSEELR------ELESKRSELRRE--------LEELREKLAQLELRLEGLEVRIDNL--- 941

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   679 isdLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFqkkqseSEVHL---QEIKAQNTQKDFelvesges 755
Cdd:TIGR02168  942 ---QERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKEL------GPVNLaaiEEYEELKERYDF-------- 1004

                          410       420
                   ....*....|....*....|....*...
gi 442628156   756 lkkLQQQLEQKTLGHEKLQAALEELKKE 783
Cdd:TIGR02168 1005 ---LTAQKEDLTEAKETLEEAIEEIDRE 1029
PTZ00121 PTZ00121
MAEBL; Provisional
 400-1002 2.21e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 65.93  E-value: 2.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  400 ERKKTEELQCSIDEAQfCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSilPPDLPSDDGALQEEIAKLQEKMTIQQ 479
Cdd:PTZ00121 1300 EKKKADEAKKKAEEAK-KADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKA--EAEAAADEAEAAEEKAEAAEKKKEEA 1376

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  480 KEvESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIEnlrreLELLKEENEKQAQEA-QAEFTR 558
Cdd:PTZ00121 1377 KK-KADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAE-----EKKKADEAKKKAEEAkKADEAK 1450

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  559 KLAE--KSVEVLRLSSElQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIR---ELNQQLDEVTTQLNVQKADSSAL 633
Cdd:PTZ00121 1451 KKAEeaKKAEEAKKKAE-EAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKkaaEAKKKADEAKKAEEAKKADEAKK 1529

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  634 DDMLRLQKEG--TEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIE 711
Cdd:PTZ00121 1530 AEEAKKADEAkkAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKA 1609

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  712 QQLalKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQqqlEQKTLGHEKLQAALEELKKEKETIIKEK 791
Cdd:PTZ00121 1610 EEA--KKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAE---EENKIKAAEEAKKAEEDKKKAEEAKKAE 1684

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  792 EQELQQLQSKSAESESALKVVQVQLEQLQQQAAasGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKqleA 871
Cdd:PTZ00121 1685 EDEKKAAEALKKEAEEAKKAEELKKKEAEEKKK--AEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKK---I 1759

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  872 ANGSLEEEAKKSGHLLEQITKLKSEVGETQaalSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQD-KVKEIT 950
Cdd:PTZ00121 1760 AHLKKEEEKKAEEIRKEKEAVIEEELDEED---EKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDsAIKEVA 1836

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|..
gi 442628156  951 DTlhAELQAERSSSSALHtKLSKFSDEIATGHKELTSKADAWSQEMLQKEKE 1002
Cdd:PTZ00121 1837 DS--KNMQLEEADAFEKH-KFNKNNENGEDGNKEADFNKEKDLKEDDEEEIE 1885
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1166-1505 2.52e-10

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 65.24  E-value: 2.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1166 QKKFEELEE-----KLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLN 1240
Cdd:PRK04778   85 EEQLFEAEElndkfRFRKAKHEINEIESLLDLIEEDIEQILEELQELLESEEKNREEVEQLKDLYRELRKSLLANRFSFG 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1241 ESNVQLENKtscLKETQDQLlesqKKEKQLQEEA--AKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAatsQLDA 1318
Cdd:PRK04778  165 PALDELEKQ---LENLEEEF----SQFVELTESGdyVEAREILDQLEEELAALEQIMEEIPELLKELQTELPD---QLQE 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1319 QQATNKELQEllvksqEN----EGNLQGESLAVTEKLQQLEQ--ANGELKEAlcqkENGLKELQGKLDESNTVLESQKKS 1392
Cdd:PRK04778  235 LKAGYRELVE------EGyhldHLDIEKEIQDLKEQIDENLAllEELDLDEA----EEKNEEIQERIDQLYDILEREVKA 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1393 HNEIQDKLEqaqqkerTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSAL 1472
Cdd:PRK04778  305 RKYVEKNSD-------TLPDFLEHAKEQNKELKEEIDRVKQSYTLNESELESVRQLEKQLESLEKQYDEITERIAEQEIA 377

                         330       340       350
                  ....*....|....*....|....*....|...
gi 442628156 1473 LEQLQNRVAELETALRQANDAQKTAYLETKELR 1505
Cdd:PRK04778  378 YSELQEELEEILKQLEEIEKEQEKLSEMLQGLR 410
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1190-1433 5.98e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 63.24  E-value: 5.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1190 SQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLenktsclKETQDQLLESQKKEKQ 1269
Cdd:COG4942    15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRI-------RALEQELAALEAELAE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1270 LQEEAAKLSGELQQVQEANGDIKDSLVKVEElvkvlEEKLQAATSQLDAQQA-TNKELQELLVKSQENEGNlqgeslAVT 1348
Cdd:COG4942    88 LEKEIAELRAELEAQKEELAELLRALYRLGR-----QPPLALLLSPEDFLDAvRRLQYLKYLAPARREQAE------ELR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1349 EKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQAN 1428
Cdd:COG4942   157 ADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236


                  ....*
gi 442628156 1429 EELQK 1433
Cdd:COG4942   237 AAAAE 241
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 991-1569 6.49e-10

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 64.22  E-value: 6.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   991 AWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEIT 1070
Cdd:pfam02463  163 AGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1071 NAEL---QHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEK 1147
Cdd:pfam02463  243 QELLrdeQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKE 322

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1148 VTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRE 1227
Cdd:pfam02463  323 KKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSE 402

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1228 SSSIIEAQNTKLNESNVQLEN-------KTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEE 1300
Cdd:pfam02463  403 EEKEAQLLLELARQLEDLLKEekkeeleILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKL 482

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1301 LVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELK-EALCQKENGLKELQGKL 1379
Cdd:pfam02463  483 QEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAiSTAVIVEVSATADEVEE 562

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1380 DESNT-VLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQAneelqKSLQQKQLLLEKGNEFDTQLAEYQKV 1458
Cdd:pfam02463  563 RQKLVrALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKA-----TLEADEDDKRAKVVEGILKDTELTKL 637

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1459 IDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSREVL--SLKAQMNGASSRSGKG 1536
Cdd:pfam02463  638 KESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLeiKKKEQREKEELKKLKL 717

                          570       580       590
                   ....*....|....*....|....*....|...
gi 442628156  1537 DEVESLDIETSLAKINFLNSIIADMQQKNDALK 1569
Cdd:pfam02463  718 EAEELLADRVQEAQDKINEELKLLKQKIDEEEE 750
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 379-697 7.05e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 64.32  E-value: 7.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   379 LQKNINELKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSILPpDLP 458
Cdd:TIGR02169  686 LKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELK-ELE 764

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   459 SDDGALQEEIAKLQEKM-TIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELvsKDEALEKFSLSEcgienlrre 537
Cdd:TIGR02169  765 ARIEELEEDLHKLEEALnDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKL--NRLTLEKEYLEK--------- 833

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   538 LELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLD 617
Cdd:TIGR02169  834 EIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIE 913

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   618 EVTTQLNVQKADSSALDDML----RLQKEGTEEKS-TLLEKTEKELVQSKEQAAKTL--------NDKEQLEKQISDLKq 684
Cdd:TIGR02169  914 KKRKRLSELKAKLEALEEELseieDPKGEDEEIPEeELSLEDVQAELQRVEEEIRALepvnmlaiQEYEEVLKRLDELK- 992

                          330
                   ....*....|...
gi 442628156   685 lAEQEKLVREMTE 697
Cdd:TIGR02169  993 -EKRAKLEEERKA 1004
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 1153-1489 1.05e-09

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 63.17  E-value: 1.05e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1153 EELKETHLQL----DERQKKFEELEEKLKQAQQSEQKLQ---QESQTSKEKLTEIQQS------LQELQDSVKQKEELVQ 1219
Cdd:pfam05622   69 EQLQEENFRLetarDDYRIKCEELEKEVLELQHRNEELTslaEEAQALKDEMDILRESsdkvkkLEATVETYKKKLEDLG 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1220 NLEEKVR--ESSSIIEAQNT--------KLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEAng 1289
Cdd:pfam05622  149 DLRRQVKllEERNAEYMQRTlqleeelkKANALRGQLETYKRQVQELHGKLSEESKKADKLEFEYKKLEEKLEALQKE-- 226

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1290 diKDSLVKVEELVKVLEEKLQAAtsqlDAQQATNKELQELLVKSQENEGNLQGE--SLAVTEKLQQLEQANGELKealCQ 1367
Cdd:pfam05622  227 --KERLIIERDTLRETNEELRCA----QLQQAELSQADALLSPSSDPGDNLAAEimPAEIREKLIRLQHENKMLR---LG 297

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1368 KEnglkelqgkldesntvlESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNE 1447
Cdd:pfam05622  298 QE-----------------GSYRERLTELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQKALQEQGSKAEDSSL 360

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 442628156  1448 FDTQLAEYQKVIDEMDDAASVKSALLEQLQN--------RVAELETALRQ 1489
Cdd:pfam05622  361 LKQKLEEHLEKLHEAQSELQKKKEQIEELEPkqdsnlaqKIDELQEALRK 410
PTZ00121 PTZ00121
MAEBL; Provisional
 1027-1519 1.34e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 63.62  E-value: 1.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1027 KEKSFEESIKNLQEEVTKAKTENLELSTGTQTTikdlqerlEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANIS 1106
Cdd:PTZ00121 1077 KDFDFDAKEDNRADEATEEAFGKAEEAKKTETG--------KAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKA 1148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1107 ATNAELSTVLEVLQAEKSEtnhIFELFEMEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEElEEKLKQAQQSEQKL 1186
Cdd:PTZ00121 1149 EDAKRVEIARKAEDARKAE---EARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEE-ERKAEEARKAEDAK 1224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1187 QQESQtskEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKK 1266
Cdd:PTZ00121 1225 KAEAV---KKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEK 1301

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1267 EKQlqEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGE--- 1343
Cdd:PTZ00121 1302 KKA--DEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAkkk 1379

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1344 SLAVTEKLQQLEQANgELKEALCQKENGLKELQGKLDESNTVLESQKKShnEIQDKLEQAQQK--ERTLQEETSKLAEQ- 1420
Cdd:PTZ00121 1380 ADAAKKKAEEKKKAD-EAKKKAEEDKKKADELKKAAAAKKKADEAKKKA--EEKKKADEAKKKaeEAKKADEAKKKAEEa 1456

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1421 --LSQLKQANEELQKSLQQKQLLLE--KGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKT 1496
Cdd:PTZ00121 1457 kkAEEAKKKAEEAKKADEAKKKAEEakKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKA 1536

                         490       500
                  ....*....|....*....|...
gi 442628156 1497 AYLETKELRRQLEslELEKSREV 1519
Cdd:PTZ00121 1537 DEAKKAEEKKKAD--ELKKAEEL 1557
mukB PRK04863
chromosome partition protein MukB;
646-1512 1.34e-09

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 63.44  E-value: 1.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  646 EKSTLLEKTEKELVQSKEQAAKTLN-------DKEQLEKQISDLK----QLAEQEKLV------REMTENAINQIQLEKE 708
Cdd:PRK04863  314 RELAELNEAESDLEQDYQAASDHLNlvqtalrQQEKIERYQADLEeleeRLEEQNEVVeeadeqQEENEARAEAAEEEVD 393

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  709 SIEQQLALKQNELEDFQKKQSESEvhlQEIKAqntqkdfelvesgesLKKLQQQLEQKTLGHEKLQAALEELKKEKetii 788
Cdd:PRK04863  394 ELKSQLADYQQALDVQQTRAIQYQ---QAVQA---------------LERAKQLCGLPDLTADNAEDWLEEFQAKE---- 451

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  789 KEKEQELQQLQSKSAESESALKVVqvqleqlqqqaaasgEEGSKTVAKLHDEISqlKSQAEETQSELKSTQSNLEAKSKQ 868
Cdd:PRK04863  452 QEATEELLSLEQKLSVAQAAHSQF---------------EQAYQLVRKIAGEVS--RSEAWDVARELLRRLREQRHLAEQ 514

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  869 LEAANGSLEEeAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAAnaaLEKVNKEYAESRAEASDLQDKVKE 948
Cdd:PRK04863  515 LQQLRMRLSE-LEQRLRQQQRAERLLAEFCKRLGKNLDDEDELEQLQEELEAR---LESLSESVSEARERRMALRQQLEQ 590

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  949 ItDTLHAELQAERSSSSALHTKLSKFSDEiaTGHKELTSKA-DAWSQEMLQKEKELQELRQqlqdsqdsqtklkaEGERK 1027
Cdd:PRK04863  591 L-QARIQRLAARAPAWLAAQDALARLREQ--SGEEFEDSQDvTEYMQQLLERERELTVERD--------------ELAAR 653

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1028 EKSFEESIKNLQEEvtkaktenlelSTGTQTTIKDLQERLE-ITNAELQhkEKMASEDAQKI-ADLKTLVEAIQVAnani 1105
Cdd:PRK04863  654 KQALDEEIERLSQP-----------GGSEDPRLNALAERFGgVLLSEIY--DDVSLEDAPYFsALYGPARHAIVVP---- 716

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1106 satnaELSTVLEVLQAEKSETNhifELFEMEADMNSerLIEKVTGIKEELKETHLQLDERQ---KKFEEL--------EE 1174
Cdd:PRK04863  717 -----DLSDAAEQLAGLEDCPE---DLYLIEGDPDS--FDDSVFSVEELEKAVVVKIADRQwrySRFPEVplfgraarEK 786

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1175 KLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQK---------EELVQNLEEKVREsssiIEAQNTKLNESNVQ 1245
Cdd:PRK04863  787 RIEQLRAEREELAERYATLSFDVQKLQRLHQAFSRFIGSHlavafeadpEAELRQLNRRRVE----LERALADHESQEQQ 862

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1246 LENKTSCLKETQDQL--LESQKK---EKQLQEEAAKLSGELQQVQEANGDIKdslvkveelvkvleeKLQAATSQLDAQQ 1320
Cdd:PRK04863  863 QRSQLEQAKEGLSALnrLLPRLNllaDETLADRVEEIREQLDEAEEAKRFVQ---------------QHGNALAQLEPIV 927

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1321 ATnkeLQEllvkSQENEGNLQGESLAVTEKLQQLEQANGELKEaLCQKENGLK--ELQGKLDESNTVLESqkkshneIQD 1398
Cdd:PRK04863  928 SV---LQS----DPEQFEQLKQDYQQAQQTQRDAKQQAFALTE-VVQRRAHFSyeDAAEMLAKNSDLNEK-------LRQ 992

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1399 KLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQlllekgnefdTQLAEYQKVIDEMDDAASvkSALLEQLQN 1478
Cdd:PRK04863  993 RLEQAEQERTRAREQLRQAQAQLAQYNQVLASLKSSYDAKR----------QMLQELKQELQDLGVPAD--SGAEERARA 1060

                         890       900       910       920
                  ....*....|....*....|....*....|....*....|..
gi 442628156 1479 RVAELETALRqANDAQKTAY--------LETKELRRQLESLE 1512
Cdd:PRK04863 1061 RRDELHARLS-ANRSRRNQLekqltfceAEMDNLTKKLRKLE 1101
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 673-1573 1.38e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 63.21  E-value: 1.38e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   673 EQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEiKAQNTQKDFELVES 752
Cdd:pfam15921   81 EEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRN-QLQNTVHELEAAKC 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   753 geslkklqqqLEQKTLGHEKLQaaLEELKKeketIIKEKEQELQQLQSKSAESESAL-KVVQVQLEQLQQQAAASGEEGS 831
Cdd:pfam15921  160 ----------LKEDMLEDSNTQ--IEQLRK----MMLSHEGVLQEIRSILVDFEEASgKKIYEHDSMSTMHFRSLGSAIS 223

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   832 KTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLeaangsLEEEAKKSGHLleqITKLKSEVGETQAALSSCHTDV 911
Cdd:pfam15921  224 KILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELL------LQQHQDRIEQL---ISEHEVEITGLTEKASSARSQA 294

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   912 ESKTKQLEAANAALEKVNKEYAEsraEASDLQDKVKEITDTLhaelqaeRSSSSALHTKLSKFSDEIATGHKELT---SK 988
Cdd:pfam15921  295 NSIQSQLEIIQEQARNQNSMYMR---QLSDLESTVSQLRSEL-------REAKRMYEDKIEELEKQLVLANSELTearTE 364

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   989 ADAWSQEMLQKEKELQelrqqlqdsqdsqtKLKAEGERKEKsfeesiknlqeEVTKAKTENLEL---STGTQTTIKDLQE 1065
Cdd:pfam15921  365 RDQFSQESGNLDDQLQ--------------KLLADLHKREK-----------ELSLEKEQNKRLwdrDTGNSITIDHLRR 419

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1066 RLEITNAELQHKEKMasedaqkiadlktlveaiqvananisatnaelstvlevLQAEKSETNHIFELfEMEADMNSERLI 1145
Cdd:pfam15921  420 ELDDRNMEVQRLEAL--------------------------------------LKAMKSECQGQMER-QMAAIQGKNESL 460

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1146 EKVTGIKEELKETHLQLderQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKV 1225
Cdd:pfam15921  461 EKVSSLTAQLESTKEML---RKVVEELTAKKMTLESSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLK 537

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1226 RESSSIIEAQnTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEangDIKDSLVKVEELvKVL 1305
Cdd:pfam15921  538 NEGDHLRNVQ-TECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEK---EINDRRLELQEF-KIL 612

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1306 EEKLQAATSQLDAqqatnkelqellvksqenegnlqgeslavteKLQQLEQANGELKEALCQKENGLKELQgklDESNTV 1385
Cdd:pfam15921  613 KDKKDAKIRELEA-------------------------------RVSDLELEKVKLVNAGSERLRAVKDIK---QERDQL 658

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1386 LESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDtqlAEYQKVIDEMDDA 1465
Cdd:pfam15921  659 LNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSD---GHAMKVAMGMQKQ 735

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1466 ASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSREVLSLKAQMngaSSRSGKGDEVESLDIE 1545
Cdd:pfam15921  736 ITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLR---SQERRLKEKVANMEVA 812

                          890       900
                   ....*....|....*....|....*...
gi 442628156  1546 TSLAKINFLNSIIADMQQKNDALKAKVQ 1573
Cdd:pfam15921  813 LDKASLQFAECQDIIQRQEQESVRLKLQ 840
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1142-1577 1.40e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 63.40  E-value: 1.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1142 ERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQS--------EQKLQQESQTSKEKLTEIQQSLQELQdsvkq 1213
Cdd:COG4913   291 ELLEAELEELRAELARLEAELERLEARLDALREELDELEAQirgnggdrLEQLEREIERLERELEERERRRARLE----- 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1214 keELVQNLEEKVRESSSIIEAQNTKLNEsnvQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQ---------- 1283
Cdd:COG4913   366 --ALLAALGLPLPASAEEFAALRAEAAA---LLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASlerrksnipa 440

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1284 -VQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKEL----QELLVKSQ------------ENEGNLQGESLA 1346
Cdd:COG4913   441 rLLALRDALAEALGLDEAELPFVGELIEVRPEEERWRGAIERVLggfaLTLLVPPEhyaaalrwvnrlHLRGRLVYERVR 520

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1347 VTEKLQQLEQAN-GELKEALCQKENGLKE-LQGKLDESNTV--------------------LESQKKSHNEIQD------ 1398
Cdd:COG4913   521 TGLPDPERPRLDpDSLAGKLDFKPHPFRAwLEAELGRRFDYvcvdspeelrrhpraitragQVKGNGTRHEKDDrrrirs 600

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1399 ----------KLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEF------DTQLAEYQKVIDEM 1462
Cdd:COG4913   601 ryvlgfdnraKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEidvasaEREIAELEAELERL 680

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1463 DDAasvkSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLEleksREVLSLKAQMNGASSRsgkGDEVESL 1542
Cdd:COG4913   681 DAS----SDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAE----EELDELQDRLEAAEDL---ARLELRA 749

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 442628156 1543 DIETSLAKI---NFLNSIIADMQQKNDALKAKVQTLET 1577
Cdd:COG4913   750 LLEERFAAAlgdAVERELRENLEERIDALRARLNRAEE 787
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 659-1457 1.80e-09

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 62.76  E-value: 1.80e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   659 VQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEI 738
Cdd:TIGR00606  185 IKALETLRQVRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIEHNLSKI 264

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   739 -KAQNTQKDFELVEsgESLKKLQQQLEQKTLG-HEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESalKVVQVQL 816
Cdd:TIGR00606  265 mKLDNEIKALKSRK--KQMEKDNSELELKMEKvFQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKLNK--ERRLLNQ 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   817 EQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSK-------QLEAANGSLEEEAKKSGHLLEQ 889
Cdd:TIGR00606  341 EKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQiknfhtlVIERQEDEAKTAAQLCADLQSK 420

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   890 ITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHT 969
Cdd:TIGR00606  421 ERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERELSKAEKNSLTETLK 500

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   970 KLSKFsdeIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTEN 1049
Cdd:TIGR00606  501 KEVKS---LQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFPNKKQLED 577

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1050 LELSTGTQttIKDLQERLEITNAELQHKEKMA----SEDAQKIADLKTLVEAI------QVANANISATNAELSTVLEVL 1119
Cdd:TIGR00606  578 WLHSKSKE--INQTRDRLAKLNKELASLEQNKnhinNELESKEEQLSSYEDKLfdvcgsQDEESDLERLKEEIEKSSKQR 655

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1120 QAEKSETNHIFELFEMEADMNSE--RLIEKVTGIKEELKETHLQLderQKKFEELEEKLKQAQQSEQKLQQESQTSKEKL 1197
Cdd:TIGR00606  656 AMLAGATAVYSQFITQLTDENQSccPVCQRVFQTEAELQEFISDL---QSKLRLAPDKLKSTESELKKKEKRRDEMLGLA 732

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1198 TEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKET---QDQLLESQKKEKQLQEEA 1274
Cdd:TIGR00606  733 PGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVtimERFQMELKDVERKIAQQA 812

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1275 AKLSGElqqvqeangDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQL 1354
Cdd:TIGR00606  813 AKLQGS---------DLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRR 883

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1355 EQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKS 1434
Cdd:TIGR00606  884 QQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENK 963

                          810       820
                   ....*....|....*....|....*...
gi 442628156  1435 LQQ--KQLLLEKGNEFDT---QLAEYQK 1457
Cdd:TIGR00606  964 IQDgkDDYLKQKETELNTvnaQLEECEK 991
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 561-1233 1.87e-09

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 62.68  E-value: 1.87e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   561 AEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQ 640
Cdd:TIGR00618  194 GKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   641 K-----EGTEEKSTLLEKTEK---------ELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLE 706
Cdd:TIGR00618  274 AqeavlEETQERINRARKAAPlaahikavtQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQ 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   707 KESIEQQLALKQNELEDFQKKQSESE--VHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEK 784
Cdd:TIGR00618  354 EIHIRDAHEVATSIREISCQQHTLTQhiHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQ 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   785 ETIIKEKEQELQ--QLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNL 862
Cdd:TIGR00618  434 ELQQRYAELCAAaiTCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHP 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   863 EAKSKQLeaanGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDL 942
Cdd:TIGR00618  514 NPARQDI----DNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNL 589

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   943 QDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELT--SKADAWSQEMLQKEKELQELRQQLQDSQDSQTK- 1019
Cdd:TIGR00618  590 QNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHlqQCSQELALKLTALHALQLTLTQERVREHALSIRv 669

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1020 LKAEGERKEKSFEESIKNLQEEVTKAKTE----NLELSTGTQTTIKDLQERLEITNAELQHKEKMASED---AQKIADLK 1092
Cdd:TIGR00618  670 LPKELLASRQLALQKMQSEKEQLTYWKEMlaqcQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREdalNQSLKELM 749

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1093 TLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEEL 1172
Cdd:TIGR00618  750 HQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQE 829

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442628156  1173 EEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIE 1233
Cdd:TIGR00618  830 EEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLNGINQIKIQFDG 890
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 383-1501 2.42e-09

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 62.76  E-value: 2.42e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   383 INELKARIVELESALDNERKKTEELQCS----IDE--AQFCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSILppd 456
Cdd:TIGR01612 1113 INKIKDDIKNLDQKIDHHIKALEEIKKKsenyIDEikAQINDLEDVADKAISNDDPEEIEKKIENIVTKIDKKKNIY--- 1189

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   457 lpSDDGALQEEIAKLQEKMTIQQ----------KEVESRIAEQLEEEQRLRENVkylneqIATLQSELVSKDEALEKFSL 526
Cdd:TIGR01612 1190 --DEIKKLLNEIAEIEKDKTSLEevkginlsygKNLGKLFLEKIDEEKKKSEHM------IKAMEAYIEDLDEIKEKSPE 1261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   527 SECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSelqnLKATSDSLESERVNktDECEILQTEVRMRD 606
Cdd:TIGR01612 1262 IENEMGIEMDIKAEMETFNISHDDDKDHHIISKKHDENISDIREKS----LKIIEDFSEESDIN--DIKKELQKNLLDAQ 1335

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   607 EQIRELNQQLDEVTTQLNVQKadssalddmlrlqkegteekstlLEKTEKELVQSKEQAaktlNDKEQLEKQISDlkQLA 686
Cdd:TIGR01612 1336 KHNSDINLYLNEIANIYNILK-----------------------LNKIKKIIDEVKEYT----KEIEENNKNIKD--ELD 1386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   687 EQEKLVREMTENAinQIQLEKESIEQQLALKqnELEDFQKKQSESEVHlqeIKAQNTQKDFELVESGESLKKLQQQLEQK 766
Cdd:TIGR01612 1387 KSEKLIKKIKDDI--NLEECKSKIESTLDDK--DIDECIKKIKELKNH---ILSEESNIDTYFKNADENNENVLLLFKNI 1459

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   767 TLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSaeseSALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLks 846
Cdd:TIGR01612 1460 EMADNKSQHILKIKKDNATNDHDFNINELKEHIDKS----KGCKDEADKNAKAIEKNKELFEQYKKDVTELLNKYSAL-- 1533

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   847 qaeETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALE 926
Cdd:TIGR01612 1534 ---AIKNKFAKTKKDSEIIIKEIKDAHKKFILEAEKSEQKIKEIKKEKFRIEDDAAKNDKSNKAAIDIQLSLENFENKFL 1610

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   927 KVnkeyaesraeaSDLQDKVKE-ITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAwSQEMLQKEKELQE 1005
Cdd:TIGR01612 1611 KI-----------SDIKKKINDcLKETESIEKKISSFSIDSQDTELKENGDNLNSLQEFLESLKDQ-KKNIEDKKKELDE 1678

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1006 LRQQLQdsqdsqtKLKAEGERKEKSFEESIKNLQEEVTKAKTENLE-LSTGTQTTIKDLQERLEITNAE-LQHKEKMASE 1083
Cdd:TIGR01612 1679 LDSEIE-------KIEIDVDQHKKNYEIGIIEKIKEIAIANKEEIEsIKELIEPTIENLISSFNTNDLEgIDPNEKLEEY 1751

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1084 DAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNS---ERLIEKVTGIKEELKEthl 1160
Cdd:TIGR01612 1752 NTEIGDIYEEFIELYNIIAGCLETVSKEPITYDEIKNTRINAQNEFLKIIEIEKKSKSyldDIEAKEFDRIINHFKK--- 1828

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1161 QLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKlteiqqslQELQDSVKQKEELVQNLEEKV-----RESSSIIEAQ 1235
Cdd:TIGR01612 1829 KLDHVNDKFTKEYSKINEGFDDISKSIENVKNSTDE--------NLLFDILNKTKDAYAGIIGKKyysykDEAEKIFINI 1900

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1236 NTKLNESNVQLENKT--SCLKETQDQLLESQKKEKqlqEEAAKLSGELQQVQEANGDIKDSLVKVEELVKvleeklqaat 1313
Cdd:TIGR01612 1901 SKLANSINIQIQNNSgiDLFDNINIAILSSLDSEK---EDTLKFIPSPEKEPEIYTKIRDSYDTLLDIFK---------- 1967

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1314 sqldAQQATNKELQELLvksqenegNLQGESLAVTEKLQQLEQANGELKEALCQKE---NGLKELQGKLDESN------- 1383
Cdd:TIGR01612 1968 ----KSQDLHKKEQDTL--------NIIFENQQLYEKIQASNELKDTLSDLKYKKEkilNDVKLLLHKFDELNklscdsq 2035

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1384 ---TVLESQKksHNEIQDKLEQAQQKERTL--QEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKV 1458
Cdd:TIGR01612 2036 nydTILELSK--QDKIKEKIDNYEKEKEKFgiDFDVKAMEEKFDNDIKDIEKFENNYKHSEKDNHDFSEEKDNIIQSKKK 2113

                         1130      1140      1150      1160
                   ....*....|....*....|....*....|....*....|...
gi 442628156  1459 IDEMDDAASVKsalLEQLQNRVAELETALRQANDAQKTAYLET 1501
Cdd:TIGR01612 2114 LKELTEAFNTE---IKIIEDKIIEKNDLIDKLIEMRKECLLFS 2153
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
367-971 2.47e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 62.24  E-value: 2.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  367 LDREDAQNQALQLQKNINELKarivELESALDNERKKTEELQcsideaqfcgdELNAQSQVYKEKIHDLEsKITKLVSAT 446
Cdd:COG4913   218 LEEPDTFEAADALVEHFDDLE----RAHEALEDAREQIELLE-----------PIRELAERYAAARERLA-ELEYLRAAL 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  447 PSLQSILppdlpsDDGALQEEIAKLQE---KMTIQQKEVESRIAEQLEEEQRLRENVKYL-NEQIATLQSELVSKDEALE 522
Cdd:COG4913   282 RLWFAQR------RLELLEAELEELRAelaRLEAELERLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELE 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  523 KfslsecgienlrreleLLKEENEKQAQEAQAEFTRKLAEKSVEVLRlsselQNLKATSDSLESERvnktdecEILQTEV 602
Cdd:COG4913   356 E----------------RERRRARLEALLAALGLPLPASAEEFAALR-----AEAAALLEALEEEL-------EALEEAL 407

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  603 RMRDEQIRELNQQLDEVTTQLNVQKADSSALD-DMLRLQKEGTEEkstlLEKTEK------ELVQSKEQAAKTLNDKEQL 675
Cdd:COG4913   408 AEAEAALRDLRRELRELEAEIASLERRKSNIPaRLLALRDALAEA----LGLDEAelpfvgELIEVRPEEERWRGAIERV 483

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  676 -----------EKQISDLKQLAEQEKL--------VREMTENAINQiQLEKESIEQQLALKQNELEDFqkkqsesevhLQ 736
Cdd:COG4913   484 lggfaltllvpPEHYAAALRWVNRLHLrgrlvyerVRTGLPDPERP-RLDPDSLAGKLDFKPHPFRAW----------LE 552

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  737 EIKAQntQKDFELVESGESLKKLQQ------QLEQKTLGHEK---------------LQAALEELKKEketiIKEKEQEL 795
Cdd:COG4913   553 AELGR--RFDYVCVDSPEELRRHPRaitragQVKGNGTRHEKddrrrirsryvlgfdNRAKLAALEAE----LAELEEEL 626

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  796 QQLQSKSAESESALKVVQVQLEQLQQQAAASGEEgsKTVAKLHDEISQLksqaEETQSELKSTQSNLEAKSKQLEAANGS 875
Cdd:COG4913   627 AEAEERLEALEAELDALQERREALQRLAEYSWDE--IDVASAEREIAEL----EAELERLDASSDDLAALEEQLEELEAE 700

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  876 LEEeakksghLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHA 955
Cdd:COG4913   701 LEE-------LEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALGDAVERELRENLEE 773

                         650
                  ....*....|....*.
gi 442628156  956 ELQAERSSSSALHTKL 971
Cdd:COG4913   774 RIDALRARLNRAEEEL 789
PTZ00121 PTZ00121
MAEBL; Provisional
 353-952 3.40e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.08  E-value: 3.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  353 EKQQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTE----ELQCSIDEAQFCGDELNA---QS 425
Cdd:PTZ00121 1294 EAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEaakaEAEAAADEAEAAEEKAEAaekKK 1373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  426 QVYKEKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEV-----------ESRIAEQLE--- 491
Cdd:PTZ00121 1374 EEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKkkadeakkkaeEAKKADEAKkka 1453

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  492 EEQRLRENVKYLNEQIATLQSelvSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLS 571
Cdd:PTZ00121 1454 EEAKKAEEAKKKAEEAKKADE---AKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKA 1530

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  572 SE---LQNLKATSDSLESERVNKTDECEILQtEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKS 648
Cdd:PTZ00121 1531 EEakkADEAKKAEEKKKADELKKAEELKKAE-EKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKA 1609

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  649 TLLEKTEKELVQSKEqaaktLNDKEQLEKQISDLKQLAEQEK-----LVREMTENAINQIQLEKESIEQQLALKQNELED 723
Cdd:PTZ00121 1610 EEAKKAEEAKIKAEE-----LKKAEEEKKKVEQLKKKEAEEKkkaeeLKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAE 1684

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  724 FQKKQSESEVHLQEIKAQNTQ----KDFELVESGESLKKLQQQLEQKTlghEKLQAALEELKKEKETIIKEKEQELQQLQ 799
Cdd:PTZ00121 1685 EDEKKAAEALKKEAEEAKKAEelkkKEAEEKKKAEELKKAEEENKIKA---EEAKKEAEEDKKKAEEAKKDEEEKKKIAH 1761

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  800 SKSAESESALKVVQVQLEQLQQQAAASGE----EGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGS 875
Cdd:PTZ00121 1762 LKKEEEKKAEEIRKEKEAVIEEELDEEDEkrrmEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKNM 1841

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442628156  876 LEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANaALEKVNKEYAESRAEASDLQDKVKEITDT 952
Cdd:PTZ00121 1842 QLEEADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEAD-EIEKIDKDDIEREIPNNNMAGKNNDIIDD 1917
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1339-1578 3.44e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 61.88  E-value: 3.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1339 NLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLA 1418
Cdd:COG1196   236 ELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELE 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1419 EQLSQLKQANEELQKSLQQKQLLLEkgnEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAY 1498
Cdd:COG1196   316 ERLEELEEELAELEEELEELEEELE---ELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEAL 392

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1499 LETKELRRQLESLELEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQKNDALKAKVQTLETL 1578
Cdd:COG1196   393 RAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEA 472
PTZ00121 PTZ00121
MAEBL; Provisional
 466-1168 3.76e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.08  E-value: 3.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  466 EEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKfslsecgiENLRRELELLKEEN 545
Cdd:PTZ00121 1293 DEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKA--------EAEAAADEAEAAEE 1364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  546 EKQAQEAQAEFTRKLAE---KSVEVLRLSSELQNlKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQldevttq 622
Cdd:PTZ00121 1365 KAEAAEKKKEEAKKKADaakKKAEEKKKADEAKK-KAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEA------- 1436

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  623 lnVQKADSSALDDMLRLQKEGTEEKSTLLEKTEkelvqsKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQ 702
Cdd:PTZ00121 1437 --KKKAEEAKKADEAKKKAEEAKKAEEAKKKAE------EAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEA 1508

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  703 IQLEKESIEQQLALKQNELEDFQKKQSESEVH-LQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAAlEELK 781
Cdd:PTZ00121 1509 KKKADEAKKAEEAKKADEAKKAEEAKKADEAKkAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKA-EEAK 1587

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  782 KEKETIIKEKEQELQQLQSKSAEsesalKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSN 861
Cdd:PTZ00121 1588 KAEEARIEEVMKLYEEEKKMKAE-----EAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIK 1662

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  862 LEAKSKQleaangslEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASD 941
Cdd:PTZ00121 1663 AAEEAKK--------AEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEE 1734

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  942 LQDKVKEitDTLHAElqaERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKElqelrqqlqdsqdsqtKLK 1021
Cdd:PTZ00121 1735 AKKEAEE--DKKKAE---EAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDE----------------KRR 1793

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1022 AEGERKEKSFEESIKNLQEevtKAKTENLELSTGTQTTIKDLQERLEITNAELqhkekmasEDAQKIADLKTLVEAIQVA 1101
Cdd:PTZ00121 1794 MEVDKKIKDIFDNFANIIE---GGKEGNLVINDSKEMEDSAIKEVADSKNMQL--------EEADAFEKHKFNKNNENGE 1862

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442628156 1102 NANISATNAELSTVLEVLQAEKSETNHIFELfeMEADMNSERLIEKVTGIKEELKETHLQLDERQKK 1168
Cdd:PTZ00121 1863 DGNKEADFNKEKDLKEDDEEEIEEADEIEKI--DKDDIEREIPNNNMAGKNNDIIDDKLDKDEYIKR 1927
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 566-1317 4.34e-09

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 61.78  E-value: 4.34e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   566 EVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNvQKADSSALDdmLRLQKEGTE 645
Cdd:pfam12128  242 EFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQWK-EKRDELNGE--LSAADAAVA 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   646 EKSTLLEKTEKELVQSKEQAAKTLN-DKEQLEKQISDLKQLAEQEKLVremtENAINQIQLEKESIEQQLALKQN-ELED 723
Cdd:pfam12128  319 KDRSELEALEDQHGAFLDADIETAAaDQEQLPSWQSELENLEERLKAL----TGKHQDVTAKYNRRRSKIKEQNNrDIAG 394

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   724 FQKKQSesevhlqeikAQNTQKDFELVESGESLKKLQQQLeqktlgHEKLQAALEELKKEKETIIKEKEQELQQLQSKSA 803
Cdd:pfam12128  395 IKDKLA----------KIREARDRQLAVAEDDLQALESEL------REQLEAGKLEFNEEEYRLKSRLGELKLRLNQATA 458

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   804 ESEsaLKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELK-------STQSNLEAKSKQLEAANGSL 876
Cdd:pfam12128  459 TPE--LLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRqasrrleERQSALDELELQLFPQAGTL 536

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   877 EEEAKKSGHLLEQitklksEVGETQAALSSCHTD-----VESKTKQ---LEAANAALEKVNKEyaesraEASDLQDKVKE 948
Cdd:pfam12128  537 LHFLRKEAPDWEQ------SIGKVISPELLHRTDldpevWDGSVGGelnLYGVKLDLKRIDVP------EWAASEEELRE 604

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   949 ITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQemlqKEKELQELRQQLqdsqdsqtklKAEGERKE 1028
Cdd:pfam12128  605 RLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKN----ARLDLRRLFDEK----------QSEKDKKN 670

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1029 KSFEESIKNLQEEVTKAKTENLELStgtqttiKDLQERLEitnaelQHKEKMASEDAQKIADLKTLVEAIQVANANISAT 1108
Cdd:pfam12128  671 KALAERKDSANERLNSLEAQLKQLD-------KKHQAWLE------EQKEQKREARTEKQAYWQVVEGALDAQLALLKAA 737

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1109 NAelstvlevlqaeKSETNHIFELFEMEADMNSERlieKVTGIKEElkethlQLDERQKKFEELEEKLKQAQQSEQKLQQ 1188
Cdd:pfam12128  738 IA------------ARRSGAKAELKALETWYKRDL---ASLGVDPD------VIAKLKREIRTLERKIERIAVRRQEVLR 796

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1189 -----------ESQTSKEKLTEIQQSLQELQDSVKQKEElvqnleekvresssiieaqNTKLNESNVQLENKTSclKETQ 1257
Cdd:pfam12128  797 yfdwyqetwlqRRPRLATQLSNIERAISELQQQLARLIA-------------------DTKLRRAKLEMERKAS--EKQQ 855

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1258 DQLLESQKKEKQLQEEAAKLSgELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLD 1317
Cdd:pfam12128  856 VRLSENLRGLRCEMSKLATLK-EDANSEQAQGSIGERLAQLEDLKLKRDYLSESVKKYVE 914
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 640-873 4.56e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 60.55  E-value: 4.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  640 QKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDL-KQLAEQEKLVREmTENAINQIQLEKESIEQQLALKQ 718
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALeRRIAALARRIRA-LEQELAALEAELAELEKEIAELR 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  719 NELEDFQKKQSESEVHLQEIKAQNT------QKDFELVESG--------ESLKKLQQQLEQKTLGHEKLQAALEELKKEK 784
Cdd:COG4942    97 AELEAQKEELAELLRALYRLGRQPPlalllsPEDFLDAVRRlqylkylaPARREQAEELRADLAELAALRAELEAERAEL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  785 ETIIKEKEQELQQLQSKSAESESALKVVqvqleqlqqqaaasgeegSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEA 864
Cdd:COG4942   177 EALLAELEEERAALEALKAERQKLLARL------------------EKELAELAAELAELQQEAEELEALIARLEAEAAA 238


                  ....*....
gi 442628156  865 KSKQLEAAN 873
Cdd:COG4942   239 AAERTPAAG 247
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1070-1571 4.74e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 61.28  E-value: 4.74e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1070 TNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERlIEKVT 1149
Cdd:pfam05483   97 IEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHLCNLLKETCARSAEK-TKKYE 175

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1150 GIKEELKETHLQLDER-QKKFEELEEKLKQAQQSEQKLQQESQTSKEKlteIQQSLQELQDSVKQKEELVQNL------- 1221
Cdd:pfam05483  176 YEREETRQVYMDLNNNiEKMILAFEELRVQAENARLEMHFKLKEDHEK---IQHLEEEYKKEINDKEKQVSLLliqitek 252

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1222 EEKVRESSSIIEAQNTKLNesnvQLENKTsclKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEEL 1301
Cdd:pfam05483  253 ENKMKDLTFLLEESRDKAN----QLEEKT---KLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKT 325

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1302 VKVLEEKLQAATSQLDAQQATNK-----------ELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKEN 1370
Cdd:pfam05483  326 ICQLTEEKEAQMEELNKAKAAHSfvvtefeattcSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEV 405

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1371 GLKELQGKLDESNTVLESQK---KSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNE 1447
Cdd:pfam05483  406 ELEELKKILAEDEKLLDEKKqfeKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKL 485

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1448 FDTQLA--------EYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAyletKELRRQLESLELEKSREV 1519
Cdd:pfam05483  486 KNIELTahcdklllENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKE----MNLRDELESVREEFIQKG 561

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442628156  1520 LSLKAQMNgASSRSGKGDEVESLDIETSLA-----------KINFLNSIIADMQQKNDALKAK 1571
Cdd:pfam05483  562 DEVKCKLD-KSEENARSIEYEVLKKEKQMKilenkcnnlkkQIENKNKNIEELHQENKALKKK 623
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 976-1577 4.93e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 61.62  E-value: 4.93e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   976 DEIAtGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEK---------SFEESIKNLQEEVTKAK 1046
Cdd:TIGR02169  160 DEIA-GVAEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAERyqallkekrEYEGYELLKEKEALERQ 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1047 TENLELSTGTQT-TIKDLQERLEITNAELQHKEKMASEDAQKIADL--------KTLVEAIQVANANISATNAELStvLE 1117
Cdd:TIGR02169  239 KEAIERQLASLEeELEKLTEEISELEKRLEEIEQLLEELNKKIKDLgeeeqlrvKEKIGELEAEIASLERSIAEKE--RE 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1118 VLQAEKSETNHIFELFEMEADM-NSERLIE----KVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQT 1192
Cdd:TIGR02169  317 LEDAEERLAKLEAEIDKLLAEIeELEREIEeerkRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEK 396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1193 SKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQE 1272
Cdd:TIGR02169  397 LKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKE 476

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1273 EAAKLSGELQQVQE--------------------ANGDIKDSLVK-----VEELVKVlEEKLQAAT-------------- 1313
Cdd:TIGR02169  477 EYDRVEKELSKLQRelaeaeaqaraseervrggrAVEEVLKASIQgvhgtVAQLGSV-GERYATAIevaagnrlnnvvve 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1314 SQLDAQQATN--KELQ---------------------------------------------------ELLVKSQEN---- 1336
Cdd:TIGR02169  556 DDAVAKEAIEllKRRKagratflplnkmrderrdlsilsedgvigfavdlvefdpkyepafkyvfgdTLVVEDIEAarrl 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1337 ---------EGNLQGESLAVT---EKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQ 1404
Cdd:TIGR02169  636 mgkyrmvtlEGELFEKSGAMTggsRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDAS 715

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1405 QKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEkgnEFDTQLAEYQKVIDEMDDAasvksalLEQLQNRVAELE 1484
Cdd:TIGR02169  716 RKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIE---NVKSELKELEARIEELEED-------LHKLEEALNDLE 785

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1485 TALRQAndaqktaylETKELRRQLESLELEKSREVLSLkAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQK 1564
Cdd:TIGR02169  786 ARLSHS---------RIPEIQAELSKLEEEVSRIEARL-REIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKE 855

                          730
                   ....*....|...
gi 442628156  1565 NDALKAKVQTLET 1577
Cdd:TIGR02169  856 IENLNGKKEELEE 868
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 379-1463 7.03e-09

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 61.22  E-value: 7.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   379 LQKNINELKArIVElESALDN--ERKKTEELQCSIDEAQfcgDEL-NAQSQVYKEKIHDLESKITKLVSATPSLQSILpp 455
Cdd:TIGR01612  673 IDALYNELSS-IVK-ENAIDNteDKAKLDDLKSKIDKEY---DKIqNMETATVELHLSNIENKKNELLDIIVEIKKHI-- 745

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   456 dlpsdDGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRenvKYlNEQIATLQSELvskdealekfslsecgieNLR 535
Cdd:TIGR01612  746 -----HGEINKDLNKILEDFKNKEKELSNKINDYAKEKDELN---KY-KSKISEIKNHY------------------NDQ 798

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   536 RELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECeilQTEVRMRDEQIREL-NQ 614
Cdd:TIGR01612  799 INIDNIKDEDAKQNYDKSKEYIKTISIKEDEIFKIINEMKFMKDDFLNKVDKFINFENNC---KEKIDSEHEQFAELtNK 875

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   615 QLDEVT-TQLNVQKA---DSSALDDMLRLQKEGTEEKSTLLEKTEK--ELVQSKEQAAKTLNDK-----EQLEKQISDLK 683
Cdd:TIGR01612  876 IKAEISdDKLNDYEKkfnDSKSLINEINKSIEEEYQNINTLKKVDEyiKICENTKESIEKFHNKqnilkEILNKNIDTIK 955

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   684 QLAEQEKLVREMTENA-INQI-QLEKesieqqlALKQNELEDFQKKQSESEVHLQEIKAQ-NTQKDFELVESGESLKKLQ 760
Cdd:TIGR01612  956 ESNLIEKSYKDKFDNTlIDKInELDK-------AFKDASLNDYEAKNNELIKYFNDLKANlGKNKENMLYHQFDEKEKAT 1028

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   761 QQLEQKTlghEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESesalkvvQVQLEQLQQQAAASGEEGSKTVAKLHDE 840
Cdd:TIGR01612 1029 NDIEQKI---EDANKNIPNIEIAIHTSIYNIIDEIEKEIGKNIEL-------LNKEILEEAEINITNFNEIKEKLKHYNF 1098

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   841 ISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSghlleqitklksevgetqaalsschtdvESKTKQLEA 920
Cdd:TIGR01612 1099 DDFGKEENIKYADEINKIKDDIKNLDQKIDHHIKALEEIKKKS----------------------------ENYIDEIKA 1150

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   921 ANAALEKVnkeyaesrAEASDLQDKVKEITDTLHaELQAERSSSSALHTKLSKFSDEIATGHKELTSkadawsqemLQKE 1000
Cdd:TIGR01612 1151 QINDLEDV--------ADKAISNDDPEEIEKKIE-NIVTKIDKKKNIYDEIKKLLNEIAEIEKDKTS---------LEEV 1212

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1001 KELQeLRQQLQDSQDSQTKLKAEGERKE---KSFEESIKNLQEevTKAKTENLELSTGTQTTIKDLQERLEITNAELQHK 1077
Cdd:TIGR01612 1213 KGIN-LSYGKNLGKLFLEKIDEEKKKSEhmiKAMEAYIEDLDE--IKEKSPEIENEMGIEMDIKAEMETFNISHDDDKDH 1289

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1078 EKMASEDAQKIADLKTLVEAIQVAN---ANISATNAELSTVLEVLQAEKSETN----HIFELFEMEADMNSERLIEKVTG 1150
Cdd:TIGR01612 1290 HIISKKHDENISDIREKSLKIIEDFseeSDINDIKKELQKNLLDAQKHNSDINlylnEIANIYNILKLNKIKKIIDEVKE 1369

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1151 IKEELKETHLQLDERQKKFEELEEKLKQAQQSEQ-KLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESS 1229
Cdd:TIGR01612 1370 YTKEIEENNKNIKDELDKSEKLIKKIKDDINLEEcKSKIESTLDDKDIDECIKKIKELKNHILSEESNIDTYFKNADENN 1449

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1230 siieaQNTKLNESNVQL-ENKTSCLKETQ------------DQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLV 1296
Cdd:TIGR01612 1450 -----ENVLLLFKNIEMaDNKSQHILKIKkdnatndhdfniNELKEHIDKSKGCKDEADKNAKAIEKNKELFEQYKKDVT 1524

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1297 KVEELVKVLEEKLQAATSQLDAQQATN--KELQELLV----KSQENEGNLQGESLAVTEKLQQLEQANgelkEALCQKEN 1370
Cdd:TIGR01612 1525 ELLNKYSALAIKNKFAKTKKDSEIIIKeiKDAHKKFIleaeKSEQKIKEIKKEKFRIEDDAAKNDKSN----KAAIDIQL 1600

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1371 GLKELQGKLDESNTVlesqKKSHNEIQDKLEQAQQKERTLQEET--SKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEF 1448
Cdd:TIGR01612 1601 SLENFENKFLKISDI----KKKINDCLKETESIEKKISSFSIDSqdTELKENGDNLNSLQEFLESLKDQKKNIEDKKKEL 1676

                         1130
                   ....*....|....*
gi 442628156  1449 DTQLAEYQKVIDEMD 1463
Cdd:TIGR01612 1677 DELDSEIEKIEIDVD 1691
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1106-1447 7.31e-09

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 60.52  E-value: 7.31e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1106 SATNAELSTVLEVLQAEKS--ETNHIFELFEMEAdmnserlieKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSE 1183
Cdd:pfam05557    1 RAELIESKARLSQLQNEKKqmELEHKRARIELEK---------KASALKRQLDRESDRNQELQKRIRLLEKREAEAEEAL 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1184 QKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLES 1263
Cdd:pfam05557   72 REQAELNRLKKKYLEALNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEA 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1264 QKKEKQLQEEAAKLSGELQQVQEANGDIKdSLVKVEELVKVLEEKLqAATSQLDAQQATNKELQELLVKSQENEGNLQGE 1343
Cdd:pfam05557  152 EQLRQNLEKQQSSLAEAEQRIKELEFEIQ-SQEQDSEIVKNSKSEL-ARIPELEKELERLREHNKHLNENIENKLLLKEE 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1344 SLAVTEKLQQLEQANGELKEALCQKENGLKELQG--KLDESNTVlesQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQL 1421
Cdd:pfam05557  230 VEDLKRKLEREEKYREEAATLELEKEKLEQELQSwvKLAQDTGL---NLRSPEDLSRRIEQLQQREIVLKEENSSLTSSA 306

                          330       340
                   ....*....|....*....|....*....
gi 442628156  1422 SQLKQANEELQ---KSLQQKQLLLEKGNE 1447
Cdd:pfam05557  307 RQLEKARRELEqelAQYLKKIEDLNKKLK 335
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1068-1514 7.41e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 60.55  E-value: 7.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1068 EITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANIsatnAELSTVLEVLQAEKSETNHIFELFEMEADMNS-ERLIE 1146
Cdd:COG4717    67 ELNLKELKELEEELKEAEEKEEEYAELQEELEELEEEL----EELEAELEELREELEKLEKLLQLLPLYQELEAlEAELA 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1147 KVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQS-EQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKV 1225
Cdd:COG4717   143 ELPERLEELEERLEELRELEEELEELEAELAELQEElEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEEL 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1226 RESSSIIEaqntklnesnvQLENKtsclketqdqlLESQKKEKQLQEEAAKLS--GELQQVQEANGDIKDSLVKVEELVK 1303
Cdd:COG4717   223 EELEEELE-----------QLENE-----------LEAAALEERLKEARLLLLiaAALLALLGLGGSLLSLILTIAGVLF 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1304 VLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESN 1383
Cdd:COG4717   281 LVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELE 360

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1384 TVLEsQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEfDTQLAEYQKVIDEMD 1463
Cdd:COG4717   361 EELQ-LEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLE-ALDEEELEEELEELE 438

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 442628156 1464 DAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETK--ELRRQLESLELE 1514
Cdd:COG4717   439 EELEELEEELEELREELAELEAELEQLEEDGELAELLQEleELKAELRELAEE 491
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1145-1526 1.31e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 59.78  E-value: 1.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1145 IEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQtSKEKLTEIQQSLQELQDSVKQKEELVQNLEEK 1224
Cdd:COG4717    73 LKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELE-KLEKLLQLLPLYQELEALEAELAELPERLEEL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1225 VRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKV 1304
Cdd:COG4717   152 EERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQ 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1305 LEEKL--QAATSQLDAQQATNKELQELLV---------KSQENEGNLQGESLAV------------TEKLQQLEQANG-E 1360
Cdd:COG4717   232 LENELeaAALEERLKEARLLLLIAAALLAllglggsllSLILTIAGVLFLVLGLlallflllarekASLGKEAEELQAlP 311

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1361 LKEALCQKE--NGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETS--KLAEQLSQLKQANEE----LQ 1432
Cdd:COG4717   312 ALEELEEEEleELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELeqEIAALLAEAGVEDEEelraAL 391

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1433 KSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASvksalLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLE 1512
Cdd:COG4717   392 EQAEEYQELKEELEELEEQLEELLGELEELLEALD-----EEELEEELEELEEELEELEEELEELREELAELEAELEQLE 466

                         410
                  ....*....|....
gi 442628156 1513 LEKSREVLSLKAQM 1526
Cdd:COG4717   467 EDGELAELLQELEE 480
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 645-1515 1.37e-08

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 59.97  E-value: 1.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  645 EEKSTLLEKT---EKELVQSKEQAAktlNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQ--LALKQN 719
Cdd:COG3096   278 NERRELSERAlelRRELFGARRQLA---EEQYRLVEMARELEELSARESDLEQDYQAASDHLNLVQTALRQQekIERYQE 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  720 ELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQL--------EQKTLGHEKLQA--ALEELK-------- 781
Cdd:COG3096   355 DLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLadyqqaldVQQTRAIQYQQAvqALEKARalcglpdl 434

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  782 -----KEKETIIKEKEQELQQ----LQSKSAESESALKVVqvqleqlqqqaaasgEEGSKTVAKLHDEISqlKSQAEETQ 852
Cdd:COG3096   435 tpenaEDYLAAFRAKEQQATEevleLEQKLSVADAARRQF---------------EKAYELVCKIAGEVE--RSQAWQTA 497

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  853 SELKSTQSNLEAKSKQLEAANGSLEEEAKksghLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEY 932
Cdd:COG3096   498 RELLRRYRSQQALAQRLQQLRAQLAELEQ----RLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQA 573

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  933 AESRAEASDLQDKVKEITdTLHAELQAERSSSSALHTKLSKFSDEIatgHKELTSKAD--AWSQEMLQKEKELQELRQQL 1010
Cdd:COG3096   574 AEAVEQRSELRQQLEQLR-ARIKELAARAPAWLAAQDALERLREQS---GEALADSQEvtAAMQQLLEREREATVERDEL 649

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1011 QdsqdsqtklkaegERKEkSFEESIKNLQEevtKAKTENLELSTgtqttikdLQERLeitNAELQHK--EKMASEDAQKI 1088
Cdd:COG3096   650 A-------------ARKQ-ALESQIERLSQ---PGGAEDPRLLA--------LAERL---GGVLLSEiyDDVTLEDAPYF 701

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1089 -ADLKTLVEAIQVAnanisatnaELSTVLEVLQAEKSETNHIFeLFEMEADMNSERLIEKvtgikEELKETHL-QLDERQ 1166
Cdd:COG3096   702 sALYGPARHAIVVP---------DLSAVKEQLAGLEDCPEDLY-LIEGDPDSFDDSVFDA-----EELEDAVVvKLSDRQ 766

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1167 ---KKFEEL--------EEKLKqaqqseqKLQQESQTSKEKLTEIQQSLQELQdsvkqkeELVQNLEEKVRESSSII--- 1232
Cdd:COG3096   767 wrySRFPEVplfgraarEKRLE-------ELRAERDELAEQYAKASFDVQKLQ-------RLHQAFSQFVGGHLAVAfap 832

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1233 --EAQNTKLNESNVQLEnktsclketqDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIkdSLVK---VEELVKVLEE 1307
Cdd:COG3096   833 dpEAELAALRQRRSELE----------RELAQHRAQEQQLRQQLDQLKEQLQLLNKLLPQA--NLLAdetLADRLEELRE 900

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1308 KLQAATSQ---LDAQQATNKELQELLVKSQ---ENEGNLQGESLAVTEKLQQLEQANGELKEALCQKEN-GLKELQGKLD 1380
Cdd:COG3096   901 ELDAAQEAqafIQQHGKALAQLEPLVAVLQsdpEQFEQLQADYLQAKEQQRRLKQQIFALSEVVQRRPHfSYEDAVGLLG 980

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1381 ESNTVLESqkkshneIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLekgNEFDTQLAEYQKVID 1460
Cdd:COG3096   981 ENSDLNEK-------LRARLEQAEEARREAREQLRQAQAQYSQYNQVLASLKSSRDAKQQTL---QELEQELEELGVQAD 1050

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 442628156 1461 emDDAAsvksallEQLQNRVAELETALRQaNDAQKTaYLETKELRRQLESLELEK 1515
Cdd:COG3096  1051 --AEAE-------ERARIRRDELHEELSQ-NRSRRS-QLEKQLTRCEAEMDSLQK 1094
NIP100 COG5244
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ...
 104-164 1.52e-08

Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227569 [Multi-domain]  Cd Length: 669  Bit Score: 59.70  E-value: 1.52e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442628156  104 IGQRVWLGGTRpGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSR 164
Cdd:COG5244     6 VNDRVLLGDKF-GTVRFIGKTKFKDGIWIGLELDDPVGKNDGSVNGVRYFHCKKRHGIFIR 65
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1142-1520 1.73e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 59.40  E-value: 1.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1142 ERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSK--EKLTEIQQSLQELQ---DSVKQKEE 1216
Cdd:COG4717    77 EEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPlyQELEALEAELAELPerlEELEERLE 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1217 LVQNLEEKVRESSSIIEAQNTKLNESNVQLENKT-SCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSL 1295
Cdd:COG4717   157 ELRELEEELEELEAELAELQEELEELLEQLSLATeEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENEL 236

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1296 VKVEELVKVLEEK-LQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALcQKENGLKE 1374
Cdd:COG4717   237 EAAALEERLKEARlLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEEL-QALPALEE 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1375 LQGKldESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQkslqQKQLLLEKGNEFDTQLAE 1454
Cdd:COG4717   316 LEEE--ELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQE----IAALLAEAGVEDEEELRA 389

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442628156 1455 YQKVIDEMDDAAsvksALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSREVL 1520
Cdd:COG4717   390 ALEQAEEYQELK----EELEELEEQLEELLGELEELLEALDEEELEEELEELEEELEELEEELEEL 451
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 852-1538 1.79e-08

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 59.58  E-value: 1.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  852 QSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTdvesKTKQLEAANAALEKvnke 931
Cdd:COG3096   353 QEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQT----RAIQYQQAVQALEK---- 424

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  932 yAESRAEASDL-QDKVKEITDTLHAELQAERSSSSALHTKLSkFSDEIATGHKEL----------TSKADAWS--QEMLq 998
Cdd:COG3096   425 -ARALCGLPDLtPENAEDYLAAFRAKEQQATEEVLELEQKLS-VADAARRQFEKAyelvckiageVERSQAWQtaRELL- 501

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  999 keKELQELRQQLQDSQDSQTKLkAEGERKEKSfEESIKNLQEEVTKAKTENLElstgTQTTIKDLQERLEITNAELqhkE 1078
Cdd:COG3096   502 --RRYRSQQALAQRLQQLRAQL-AELEQRLRQ-QQNAERLLEEFCQRIGQQLD----AAEELEELLAELEAQLEEL---E 570

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1079 KMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFElfemeadmNSERLIEKVTGIKEELKET 1158
Cdd:COG3096   571 EQAAEAVEQRSELRQQLEQLRARIKELAARAPAWLAAQDALERLREQSGEALA--------DSQEVTAAMQQLLEREREA 642

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1159 HLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEK-----LTEIQQ--SLQE----------------LQDSVKQKE 1215
Cdd:COG3096   643 TVERDELAARKQALESQIERLSQPGGAEDPRLLALAERlggvlLSEIYDdvTLEDapyfsalygparhaivVPDLSAVKE 722

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1216 ELvQNLEEkVRESSSIIEAQNTKLNES--NVQLENKTSCLKETQDQLLESQ----------KKEKQLQ----------EE 1273
Cdd:COG3096   723 QL-AGLED-CPEDLYLIEGDPDSFDDSvfDAEELEDAVVVKLSDRQWRYSRfpevplfgraAREKRLEelraerdelaEQ 800

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1274 AAKLSGELQQVQEANGDIKDSLVK---------VEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQG-- 1342
Cdd:COG3096   801 YAKASFDVQKLQRLHQAFSQFVGGhlavafapdPEAELAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLLNKll 880

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1343 --------ESLAvtEKLQQLEQANGELKEA---LCQKENGLKELQGKLDesntVLESQKKSHNEIQDKLEQAQQKERTLQ 1411
Cdd:COG3096   881 pqanlladETLA--DRLEELREELDAAQEAqafIQQHGKALAQLEPLVA----VLQSDPEQFEQLQADYLQAKEQQRRLK 954

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1412 EETSKLAE---------------QLSQLKQANEELQKSLQQKQLLLEKGNE----FDTQLAEYQKVIDEMDDAASVKSAL 1472
Cdd:COG3096   955 QQIFALSEvvqrrphfsyedavgLLGENSDLNEKLRARLEQAEEARREAREqlrqAQAQYSQYNQVLASLKSSRDAKQQT 1034

                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442628156 1473 LEQLQNRVAELEtaLRQANDAQKTAYLETKELRRQLESL-----ELEKSREVlsLKAQMNGASSRSGKGDE 1538
Cdd:COG3096  1035 LQELEQELEELG--VQADAEAEERARIRRDELHEELSQNrsrrsQLEKQLTR--CEAEMDSLQKRLRKAER 1101
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
651-1387 1.94e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 59.54  E-value: 1.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  651 LEKTEKELVQSKEQAaKTLndkEQLEKQISDLKQLAEQEKLVREM--------TENAINQIQLEKESIEQQLALKQNELE 722
Cdd:COG4913   237 LERAHEALEDAREQI-ELL---EPIRELAERYAAARERLAELEYLraalrlwfAQRRLELLEAELEELRAELARLEAELE 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  723 DFQKKQSESEVHLQEIKAQNTQKDfelvesGESLKKLQQQLEQKTLGHEKLQAALEELkkeketiikekEQELQQLQSKS 802
Cdd:COG4913   313 RLEARLDALREELDELEAQIRGNG------GDRLEQLEREIERLERELEERERRRARL-----------EALLAALGLPL 375

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  803 AESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSE---LKSTQSNLEAKS----KQLEAANGS 875
Cdd:COG4913   376 PASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEiasLERRKSNIPARLlalrDALAEALGL 455

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  876 LEEEAKKSGHLLEqitkLKSEVGETQAA----LSSCHTD--VESktkqlEAANAALEKVNKEYAESRaeasdLQ-DKVKE 948
Cdd:COG4913   456 DEAELPFVGELIE----VRPEEERWRGAiervLGGFALTllVPP-----EHYAAALRWVNRLHLRGR-----LVyERVRT 521

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  949 ITDTLHAELQAERSSSSALHTKLSKFSDEIatgHKELTSKADAWSQEmlqkekELQELRQqlqdsqdsqtklkaegerke 1028
Cdd:COG4913   522 GLPDPERPRLDPDSLAGKLDFKPHPFRAWL---EAELGRRFDYVCVD------SPEELRR-------------------- 572

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1029 ksfeesiknlqeeVTKAKTENLELSTGTQTTIKDLQERLEitnAELQhkekMASEDAQKIADLKTLVEAIQVANANISAT 1108
Cdd:COG4913   573 -------------HPRAITRAGQVKGNGTRHEKDDRRRIR---SRYV----LGFDNRAKLAALEAELAELEEELAEAEER 632

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1109 NAELSTVLEVLQAEKSETNHIFELFEMEADMNSerLIEKVTGIKEELKethlQLDERQKKFEELEEKLKQAQQSEQKLQQ 1188
Cdd:COG4913   633 LEALEAELDALQERREALQRLAEYSWDEIDVAS--AEREIAELEAELE----RLDASSDDLAALEEQLEELEAELEELEE 706

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1189 ESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVResssiiEAQNTKLnesnvqlenktsclketqDQLLESQKKEK 1268
Cdd:COG4913   707 ELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLAR------LELRALL------------------EERFAAALGDA 762

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1269 QLQEEAAKLSGELQQVQEANGDikdslvKVEELVKVLEEKLQ---AATSQLDAQQATNKELQELLVKsqenegnLQGESL 1345
Cdd:COG4913   763 VERELRENLEERIDALRARLNR------AEEELERAMRAFNRewpAETADLDADLESLPEYLALLDR-------LEEDGL 829

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*
gi 442628156 1346 AVTEK--LQQLEQANGELKEALCQK-ENGLKELQGKLDESNTVLE 1387
Cdd:COG4913   830 PEYEErfKELLNENSIEFVADLLSKlRRAIREIKERIDPLNDSLK 874
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 346-1285 2.53e-08

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 59.03  E-value: 2.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   346 SMQDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVELESALdneRKKTEELQCSIDEAQfcgDELNAQS 425
Cdd:pfam01576  187 AMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQL---AKKEEELQAALARLE---EETAQKN 260

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   426 QVYKeKIHDLESKITKLvsatpslqsilppdlpsddgalqeeiaklqekmtiqQKEVESRIAEQLEEEQRLRENVKYLNE 505
Cdd:pfam01576  261 NALK-KIRELEAQISEL------------------------------------QEDLESERAARNKAEKQRRDLGEELEA 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   506 QIATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLE 585
Cdd:pfam01576  304 LKTELEDTLDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALE 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   586 SERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLN-VQKADSSALDDMLRLQKEgTEEKSTLLEKTEKELVQSKEQ 664
Cdd:pfam01576  384 SENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSeSERQRAELAEKLSKLQSE-LESVSSLLNEAEGKNIKLSKD 462

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   665 AAktlndkeQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQnTQ 744
Cdd:pfam01576  463 VS-------SLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKK-LE 534

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   745 KDFELVESG-ESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQA 823
Cdd:pfam01576  535 EDAGTLEALeEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEK 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   824 AASgeegsktvAKLHDEISQLKSQAEETQSELKSTqsnleakSKQLEAANGSLEEeakksghLLEQITKLKSEVGEtqaa 903
Cdd:pfam01576  615 AIS--------ARYAEERDRAEAEAREKETRALSL-------ARALEEALEAKEE-------LERTNKQLRAEMED---- 668

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   904 LSSCHTDVESKTKQLEAANAALEkvnkeyaesrAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHK 983
Cdd:pfam01576  669 LVSSKDDVGKNVHELERSKRALE----------QQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKAQFERDLQARDE 738

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   984 ELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTenlelstgTQTTIKDL 1063
Cdd:pfam01576  739 QGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLKK--------LQAQMKDL 810

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1064 QERLEITNAELQHKEKMASEDAQKI----ADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFElfemeadm 1139
Cdd:pfam01576  811 QRELEEARASRDEILAQSKESEKKLknleAELLQLQEDLAASERARRQAQQERDELADEIASGASGKSALQD-------- 882

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1140 NSERLIEKVTGIKEELKETHLQ---LDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKL----TEIQQSLQELQDSVK 1212
Cdd:pfam01576  883 EKRRLEARIAQLEEELEEEQSNtelLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLerqnKELKAKLQEMEGTVK 962

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442628156  1213 QKEEL-VQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQ 1285
Cdd:pfam01576  963 SKFKSsIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLK 1036
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 779-1443 2.66e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 59.29  E-value: 2.66e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   779 ELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGS-------KTVAKLHDEISQL------- 844
Cdd:TIGR00606  109 EFKTLEGVITRYKHGEKVSLSSKCAEIDREMISHLGVSKAVLNNVIFCHQEDSnwplsegKALKQKFDEIFSAtryikal 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   845 ----------KSQAEETQSELKSTQSNLEAKSK---QLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHtDV 911
Cdd:TIGR00606  189 etlrqvrqtqGQKVQEHQMELKYLKQYKEKACEirdQITSKEAQLESSREIVKSYENELDPLKNRLKEIEHNLSKIM-KL 267

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   912 ESKTKQLEAANAALEKVNKEYAESRAEA-SDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKAD 990
Cdd:TIGR00606  268 DNEIKALKSRKKQMEKDNSELELKMEKVfQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKLNKERRLLNQEKTELLV 347

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   991 AWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTEnlELSTGTQTTikdlqerleit 1070
Cdd:TIGR00606  348 EQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIKNFHTLVIERQED--EAKTAAQLC----------- 414

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1071 nAELQHKEKMASEDAQKIADLKT-LVEAIQVANANISATNAELSTVLEVLQaeksetnhifelfemEADMNSERLIEKvt 1149
Cdd:TIGR00606  415 -ADLQSKERLKQEQADEIRDEKKgLGRTIELKKEILEKKQEELKFVIKELQ---------------QLEGSSDRILEL-- 476

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1150 giKEELKETHLQLDERQKKfeELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESS 1229
Cdd:TIGR00606  477 --DQELRKAERELSKAEKN--SLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIR 552

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1230 SIIEAQNTKLNESNVQLENKtsclKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKL 1309
Cdd:TIGR00606  553 KIKSRHSDELTSLLGYFPNK----KQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKL 628

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1310 QAATSQlDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLE--------------QANGELKEALCQKENGLKEL 1375
Cdd:TIGR00606  629 FDVCGS-QDEESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTdenqsccpvcqrvfQTEAELQEFISDLQSKLRLA 707

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442628156  1376 QGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLE 1443
Cdd:TIGR00606  708 PDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLG 775
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1165-1577 2.76e-08

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 58.88  E-value: 2.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1165 RQKKFEELEEKLKQAQ----QSEQKL-------------------------QQESQ------TSKEKLTEIQQSLQELQD 1209
Cdd:TIGR04523   31 QDTEEKQLEKKLKTIKnelkNKEKELknldknlnkdeekinnsnnkikileQQIKDlndklkKNKDKINKLNSDLSKINS 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1210 SVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANG 1289
Cdd:TIGR04523  111 EIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNID 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1290 DIKDSLVKVEELVKVLEEKLQ---AATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALC 1366
Cdd:TIGR04523  191 KIKNKLLKLELLLSNLKKKIQknkSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLS 270

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1367 QKENGLKELQGKLDESN----------TVLESQKKS--HNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKS 1434
Cdd:TIGR04523  271 EKQKELEQNNKKIKELEkqlnqlkseiSDLNNQKEQdwNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKE 350

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1435 LQQKQLlleKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDaqktaylETKELRRQLESLELE 1514
Cdd:TIGR04523  351 LTNSES---ENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEK-------LNQQKDEQIKKLQQE 420

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442628156  1515 KSrevLSLKAQMNGASSRSGKGDEVESLDIETSLAK--INFLNSIIADMQQKNDALKAKVQTLET 1577
Cdd:TIGR04523  421 KE---LLEKEIERLKETIIKNNSEIKDLTNQDSVKEliIKNLDNTRESLETQLKVLSRSINKIKQ 482
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 995-1507 2.85e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 58.96  E-value: 2.85e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   995 EMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKaktenlelSTGTQTTIKDLQERLEITNAEL 1074
Cdd:pfam05483  100 ELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKE--------NNATRHLCNLLKETCARSAEKT 171

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1075 QHKEKMASEDAQKIADLKTLVEAIQVA--NANISATNAELSTVLEvLQAEKSETNHIFELFEMEADMNSER---LIEKVT 1149
Cdd:pfam05483  172 KKYEYEREETRQVYMDLNNNIEKMILAfeELRVQAENARLEMHFK-LKEDHEKIQHLEEEYKKEINDKEKQvslLLIQIT 250

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1150 GIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESS 1229
Cdd:pfam05483  251 EKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLT 330

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1230 SIIEAQNTKLNESN-------VQLENKTSCLKE---TQDQLLEsqKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVE 1299
Cdd:pfam05483  331 EEKEAQMEELNKAKaahsfvvTEFEATTCSLEEllrTEQQRLE--KNEDQLKIITMELQKKSSELEEMTKFKNNKEVELE 408

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1300 ELVKVLEEKlqaaTSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGK- 1378
Cdd:pfam05483  409 ELKKILAED----EKLLDEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEk 484

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1379 ------LDESNTVLESQKKSHNEIQD---KLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQ-KQLLLEKGNEF 1448
Cdd:pfam05483  485 lknielTAHCDKLLLENKELTQEASDmtlELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESvREEFIQKGDEV 564

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 442628156  1449 DTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQ 1507
Cdd:pfam05483  565 KCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKK 623
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1258-1529 3.31e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 58.77  E-value: 3.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1258 DQLLEsqkkEKQLQEEAAKLSGELQQVQEAngdiKDSLVKVEELVKVLE------EKLQAATSQLDAQQATnKELQELLV 1331
Cdd:COG4913   215 EYMLE----EPDTFEAADALVEHFDDLERA----HEALEDAREQIELLEpirelaERYAAARERLAELEYL-RAALRLWF 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1332 KSQENEgnlqgeslAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDEsntvLESQKKSHNeiQDKLEQAQQKERTLQ 1411
Cdd:COG4913   286 AQRRLE--------LLEAELEELRAELARLEAELERLEARLDALREELDE----LEAQIRGNG--GDRLEQLEREIERLE 351

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1412 EETSKLAEQLSQLKQANEELqkslqqkqlllekGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQAN 1491
Cdd:COG4913   352 RELEERERRRARLEALLAAL-------------GLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLR 418

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 442628156 1492 DaqktaylETKELRRQLESLELEKS---REVLSLKAQMNGA 1529
Cdd:COG4913   419 R-------ELRELEAEIASLERRKSnipARLLALRDALAEA 452
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1307-1536 3.41e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.47  E-value: 3.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1307 EKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVL 1386
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1387 ESQKKSHNEIQDKLEQAQQKERTL----QEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEM 1462
Cdd:COG4942   100 EAQKEELAELLRALYRLGRQPPLAlllsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEAL 179

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442628156 1463 DDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSREVLSLKAQMNGASSRSGKG 1536
Cdd:COG4942   180 LAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALKG 253
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 607-810 3.83e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.47  E-value: 3.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  607 EQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQisdlkqLA 686
Cdd:COG4942    27 AELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE------LE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  687 EQEKLVREMtenaINQIQLEKESIEQQLALKQNELEDFQKKQSesevHLQEIKAQNTQKDFELVESGESLKKLQQQLEQK 766
Cdd:COG4942   101 AQKEELAEL----LRALYRLGRQPPLALLLSPEDFLDAVRRLQ----YLKYLAPARREQAEELRADLAELAALRAELEAE 172

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 442628156  767 TLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALK 810
Cdd:COG4942   173 RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELA 216
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1024-1483 4.63e-08

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 58.17  E-value: 4.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1024 GERKE-KSFEESIKNLQEEVTKAKT-----------ENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQK-IAD 1090
Cdd:COG5022   807 GSRKEyRSYLACIIKLQKTIKREKKlreteevefslKAEVLIQKFGRSLKAKKRFSLLKKETIYLQSAQRVELAERqLQE 886

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1091 LKTLVEAIQvanaNISATNAEL-STVLEVLQAEKS----ETNHIFELFEMEADMNSERLIEKVTGIKEELKETHLQLDER 1165
Cdd:COG5022   887 LKIDVKSIS----SLKLVNLELeSEIIELKKSLSSdlieNLEFKTELIARLKKLLNNIDLEEGPSIEYVKLPELNKLHEV 962

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1166 QKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESnvq 1245
Cdd:COG5022   963 ESKLKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQYGALQESTKQLKELPVEVAELQSASKIISSES--- 1039

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1246 leNKTSCLKETQDQLLESQKKEKQLQEEAAKLsgelqQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKE 1325
Cdd:COG5022  1040 --TELSILKPLQKLKGLLLLENNQLQARYKAL-----KLRRENSLLDDKQLYQLESTENLLKTINVKDLEVTNRNLVKPA 1112

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1326 -LQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEAlcqkengLKELQGKLDESNTVLESQKKSHNEIQDKLEQA- 1403
Cdd:COG5022  1113 nVLQFIVAQMIKLNLLQEISKFLSQLVNTLEPVFQKLSVL-------QLELDGLFWEANLEALPSPPPFAALSEKRLYQs 1185

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1404 ---QQKERTLQEETSKLAEQLSQL-KQANEELQKSLQQKQLLLEK--GNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQ 1477
Cdd:COG5022  1186 alyDEKSKLSSSEVNDLKNELIALfSKIFSGWPRGDKLKKLISEGwvPTEYSTSLKGFNNLNKKFDTPASMSNEKLLSLL 1265


                  ....*.
gi 442628156 1478 NRVAEL 1483
Cdd:COG5022  1266 NSIDNL 1271
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
351-899 4.67e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 58.15  E-value: 4.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  351 LREKQQHVEKLMVERDLDRE---DAQNQALQLQKNINELKARIVELESALDNERKKTEELQ------CSIDEAQFCGDEL 421
Cdd:PRK03918  219 LREELEKLEKEVKELEELKEeieELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEekvkelKELKEKAEEYIKL 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  422 NAQSQVYKEKIHDLESKITKLVSATPSLQSILppdlpSDDGALQEEIAKLQEKMtiqqKEVESRIAEqLEEEQRLRENVK 501
Cdd:PRK03918  299 SEFYEEYLDELREIEKRLSRLEEEINGIEERI-----KELEEKEERLEELKKKL----KELEKRLEE-LEERHELYEEAK 368

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  502 YLNEQIATLQSELvsKDEALEKFslsecgienlrrelellkEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATS 581
Cdd:PRK03918  369 AKKEELERLKKRL--TGLTPEKL------------------EKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAI 428

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  582 DSLESERvnktDECEILQTEvrMRDEQIRELnqqLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKtEKELVQS 661
Cdd:PRK03918  429 EELKKAK----GKCPVCGRE--LTEEHRKEL---LEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKK-ESELIKL 498

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  662 KEQAAKTLNDKEQLEK-QISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKqNELEDFQKKQSESEVHLQEIKA 740
Cdd:PRK03918  499 KELAEQLKELEEKLKKyNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELK-KKLAELEKKLDELEEELAELLK 577

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  741 QNTQKDFELVESGES-LKKLQ----QQLEQKTLGHEkLQAALEELKKEKETiIKEKEQELQQLQSKSAESESALKVVQVQ 815
Cdd:PRK03918  578 ELEELGFESVEELEErLKELEpfynEYLELKDAEKE-LEREEKELKKLEEE-LDKAFEELAETEKRLEELRKELEELEKK 655

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  816 -LEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANgSLEEEAKKSGHLLEQITKLK 894
Cdd:PRK03918  656 ySEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELE-KLEKALERVEELREKVKKYK 734


                  ....*
gi 442628156  895 SEVGE 899
Cdd:PRK03918  735 ALLKE 739
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1038-1528 4.74e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 58.31  E-value: 4.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1038 LQEEVTKAKTENLELST------GTQTTIKDLQERLEITNAELqhKEKMASEDAQkiadlktlveaiqvANANISATNAE 1111
Cdd:pfam12128  246 LQQEFNTLESAELRLSHlhfgykSDETLIASRQEERQETSAEL--NQLLRTLDDQ--------------WKEKRDELNGE 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1112 LSTVLEVLQAEKSEtnhiFELFEMEADMNSERLIEKVTGIKEelkethlQLDERQKKFEELEEKLKQAQQSEQKLQQESQ 1191
Cdd:pfam12128  310 LSAADAAVAKDRSE----LEALEDQHGAFLDADIETAAADQE-------QLPSWQSELENLEERLKALTGKHQDVTAKYN 378

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1192 TSKEKLteiqqSLQELQDSVKQKEELVQNLEEKVR---ESSSIIEAQNTKLNEsnvqlenktsclkETQDQLLESQKKEK 1268
Cdd:pfam12128  379 RRRSKI-----KEQNNRDIAGIKDKLAKIREARDRqlaVAEDDLQALESELRE-------------QLEAGKLEFNEEEY 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1269 QLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQqatnKELQELLVKSQENEGNLQGESLAVT 1348
Cdd:pfam12128  441 RLKSRLGELKLRLNQATATPELLLQLENFDERIERAREEQEAANAEVERLQ----SELRQARKRRDQASEALRQASRRLE 516

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1349 EKLQQLEQAN-------GELKEALCQKENGLKELQGKL---------------------DESN---TVLESQKKSHNEIQ 1397
Cdd:pfam12128  517 ERQSALDELElqlfpqaGTLLHFLRKEAPDWEQSIGKVispellhrtdldpevwdgsvgGELNlygVKLDLKRIDVPEWA 596

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1398 DKLEQAQQK----ERTLQEETSKLAEQLSQLKQANEELQKS---------------LQQKQLLLEKGNEFDT---QLAEY 1455
Cdd:pfam12128  597 ASEEELRERldkaEEALQSAREKQAAAEEQLVQANGELEKAsreetfartalknarLDLRRLFDEKQSEKDKknkALAER 676

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442628156  1456 QK-VIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRR-QLESLELEKSREVLSLKAQMNG 1528
Cdd:pfam12128  677 KDsANERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGALDaQLALLKAAIAARRSGAKAELKA 751
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1154-1364 5.17e-08

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 57.15  E-value: 5.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1154 ELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIE 1233
Cdd:COG3883    17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALY 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1234 AQNTKLNESNVQLENKT-----------SCLKETQDQLLESQKKEK-QLQEEAAKLSGELQQVQEANGDIKDSLVKVEEL 1301
Cdd:COG3883    97 RSGGSVSYLDVLLGSESfsdfldrlsalSKIADADADLLEELKADKaELEAKKAELEAKLAELEALKAELEAAKAELEAQ 176

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442628156 1302 VKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEA 1364
Cdd:COG3883   177 QAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 239
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1028-1532 6.84e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 57.62  E-value: 6.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1028 EKSFEESIKNLQEEVtkaktENLElstGTQTTIKDLQERLEITNAELQHKEKMAsEDAQKIADLKTLVEAIQVANANISA 1107
Cdd:COG4913   220 EPDTFEAADALVEHF-----DDLE---RAHEALEDAREQIELLEPIRELAERYA-AARERLAELEYLRAALRLWFAQRRL 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1108 tnAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIE-----------KVTGIKEELKETHLQLDERQKKFEELEEKL 1176
Cdd:COG4913   291 --ELLEAELEELRAELARLEAELERLEARLDALREELDEleaqirgnggdRLEQLEREIERLERELEERERRRARLEALL 368

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1177 KQAQQSE-------QKLQQESQTSKEKLTEIQQSLQELQDSVKQKEelvQNLEEKVRESSSIIEAqntklnesnvqLENK 1249
Cdd:COG4913   369 AALGLPLpasaeefAALRAEAAALLEALEEELEALEEALAEAEAAL---RDLRRELRELEAEIAS-----------LERR 434

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1250 TSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDS------------LV------KVEELV--------- 1302
Cdd:COG4913   435 KSNIPARLLALRDALAEALGLDEAELPFVGELIEVRPEEERWRGAiervlggfaltlLVppehyaAALRWVnrlhlrgrl 514

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1303 ---KVLEEKLQAATSQLDAQQATNK----------ELQELLVKSQ-----ENEGNLQGESLAVTEKLQ------------ 1352
Cdd:COG4913   515 vyeRVRTGLPDPERPRLDPDSLAGKldfkphpfraWLEAELGRRFdyvcvDSPEELRRHPRAITRAGQvkgngtrhekdd 594

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1353 --------QLEQANGELKEALcQKEngLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKE---------RTLQEETS 1415
Cdd:COG4913   595 rrrirsryVLGFDNRAKLAAL-EAE--LAELEEELAEAEERLEALEAELDALQERREALQRLAeyswdeidvASAEREIA 671

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1416 KLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQK 1495
Cdd:COG4913   672 ELEAELERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALL 751

                         570       580       590
                  ....*....|....*....|....*....|....*..
gi 442628156 1496 TAYLETKELRRQLESLELEKSREVLSLKAQMNGASSR 1532
Cdd:COG4913   752 EERFAAALGDAVERELRENLEERIDALRARLNRAEEE 788
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
878-1500 1.05e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 57.23  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  878 EEAKKSGHLLEQITKLKSEVGETQAALSSCHT-----DVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDT 952
Cdd:COG4913   245 EDAREQIELLEPIRELAERYAAARERLAELEYlraalRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREE 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  953 LhAELQAERSSSsalhtklskfsdeiatGHKELtskaDAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFE 1032
Cdd:COG4913   325 L-DELEAQIRGN----------------GGDRL----EQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFA 383

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1033 ESIKNLQEEVTKAKTE---NLELSTGTQTTIKDLQERLEITNAELQH---------------KEKMASEDAQKIADLKTL 1094
Cdd:COG4913   384 ALRAEAAALLEALEEEleaLEEALAEAEAALRDLRRELRELEAEIASlerrksniparllalRDALAEALGLDEAELPFV 463

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1095 VEAIQVANANISATNA-E----------------LSTVLEVLQAEKSETNHIFELFE--------MEADMNSerLIEKVT 1149
Cdd:COG4913   464 GELIEVRPEEERWRGAiErvlggfaltllvppehYAAALRWVNRLHLRGRLVYERVRtglpdperPRLDPDS--LAGKLD 541

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1150 gIK------------------------EELKE---------------THLQLDERQKKFEEL------EEKLKQAQQSEQ 1184
Cdd:COG4913   542 -FKphpfrawleaelgrrfdyvcvdspEELRRhpraitragqvkgngTRHEKDDRRRIRSRYvlgfdnRAKLAALEAELA 620

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1185 KLQQESQTSKEKLTEIQQSLQELQdsvkQKEELVQNLEEKVRESSSIIEAQnTKLNESNVQLENktscLKETQDQLLESQ 1264
Cdd:COG4913   621 ELEEELAEAEERLEALEAELDALQ----ERREALQRLAEYSWDEIDVASAE-REIAELEAELER----LDASSDDLAALE 691

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1265 KKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATN--KELQELLVKSQENE--GNL 1340
Cdd:COG4913   692 EQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALleERFAAALGDAVERElrENL 771

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1341 QGESLAVTEKLQQLEQANGELKEALCQK-ENGLKELQGKLDEsntvLESQKKSHNEIQ-DKLEQAQQKERTLQEETS--K 1416
Cdd:COG4913   772 EERIDALRARLNRAEEELERAMRAFNREwPAETADLDADLES----LPEYLALLDRLEeDGLPEYEERFKELLNENSieF 847

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1417 LAEQLSQLKQANEE-------LQKSLQQKQ------LLLEKGNEFDTQLAEYQKVIDEMDDAASVKSA-LLEQLQNRVAE 1482
Cdd:COG4913   848 VADLLSKLRRAIREikeridpLNDSLKRIPfgpgryLRLEARPRPDPEVREFRQELRAVTSGASLFDEeLSEARFAALKR 927

                         730
                  ....*....|....*...
gi 442628156 1483 LETALRQANDAQKTAYLE 1500
Cdd:COG4913   928 LIERLRSEEEESDRRWRA 945
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1145-1538 1.47e-07

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 56.52  E-value: 1.47e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1145 IEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESqtskEKLTEIQQSLQELQDSVKQKEELVQNLEEK 1224
Cdd:pfam02463  144 IEIIAMMKPERRLEIEEEAAGSRLKRKKKEALKKLIEETENLAELI----IDLEELKLQELKLKEQAKKALEYYQLKEKL 219

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1225 VRESSSIIEAQNTKLNESNvqlenktscLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKV 1304
Cdd:pfam02463  220 ELEEEYLLYLDYLKLNEER---------IDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKL 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1305 LEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNT 1384
Cdd:pfam02463  291 LAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQ 370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1385 VLESQKKSHNEIQDKLEQAQ---QKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDE 1461
Cdd:pfam02463  371 LEEELLAKKKLESERLSSAAklkEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEK 450

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442628156  1462 mddAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSREVLSLKAqMNGASSRSGKGDE 1538
Cdd:pfam02463  451 ---EELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLK-VLLALIKDGVGGR 523
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1020-1525 1.71e-07

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 56.29  E-value: 1.71e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1020 LKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQttikDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQ 1099
Cdd:pfam05557   14 LQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQ----ELQKRIRLLEKREAEAEEALREQAELNRLKKKYLEALN 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1100 VANANISATNAELSTVLEVLQAEKSETNHIFelfeMEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQA 1179
Cdd:pfam05557   90 KKLNEKESQLADAREVISCLKNELSELRRQI----QRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQQSSL 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1180 QQSEQKLQQESQ--TSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEaQNTKLNESNVQLENKTSCLKETQ 1257
Cdd:pfam05557  166 AEAEQRIKELEFeiQSQEQDSEIVKNSKSELARIPELEKELERLREHNKHLNENIE-NKLLLKEEVEDLKRKLEREEKYR 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1258 DQL----LESQKKEKQLQE-------------EAAKLSGELQQVQ-------EANGDIKDSLVKVEELVKVLEEKLQAAT 1313
Cdd:pfam05557  245 EEAatleLEKEKLEQELQSwvklaqdtglnlrSPEDLSRRIEQLQqreivlkEENSSLTSSARQLEKARRELEQELAQYL 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1314 SQLDAQQATNKELQELLVKSQE------NEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESN---T 1384
Cdd:pfam05557  325 KKIEDLNKKLKRHKALVRRLQRrvllltKERDGYRAILESYDKELTMSNYSPQLLERIEEAEDMTQKMQAHNEEMEaqlS 404

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1385 VLESQKKSHNEIQDKLEQAQQ--KERTLQEETSKLAEQLSQLKQANEELQkslQQKQLLLEKGNEFDTQLA--EYQKVID 1460
Cdd:pfam05557  405 VAEEELGGYKQQAQTLERELQalRQQESLADPSYSKEEVDSLRRKLETLE---LERQRLREQKNELEMELErrCLQGDYD 481

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1461 E------------MDDAASVKSALLEQLQNRV-----------AELETALRQANDAQKTAYLETKELRRQLESLEL--EK 1515
Cdd:pfam05557  482 PkktkvlhlsmnpAAEAYQQRKNQLEKLQAEIerlkrllkkleDDLEQVLRLPETTSTMNFKEVLDLRKELESAELknQR 561

                          570
                   ....*....|
gi 442628156  1516 SREVLSLKAQ 1525
Cdd:pfam05557  562 LKEVFQAKIQ 571
PRK11281 PRK11281
mechanosensitive channel MscK;
1254-1497 2.07e-07

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 56.07  E-value: 2.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1254 KETQDQLlESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLE---EKLQAATSQLDAQQATNKElqell 1330
Cdd:PRK11281   39 ADVQAQL-DALNKQKLLEAEDKLVQQDLEQTLALLDKIDRQKEETEQLKQQLAqapAKLRQAQAELEALKDDNDE----- 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1331 VKSQENEgnlqgeslavTEKLQQLEQangelkeALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKertL 1410
Cdd:PRK11281  113 ETRETLS----------TLSLRQLES-------RLAQTLDQLQNAQNDLAEYNSQLVSLQTQPERAQAALYANSQR---L 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1411 QEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAE--------YQKVIDEMddaaSVKSALLEQ----LQN 1478
Cdd:PRK11281  173 QQIRNLLKGGKVGGKALRPSQRVLLQAEQALLNAQNDLQRKSLEgntqlqdlLQKQRDYL----TARIQRLEHqlqlLQE 248

                         250       260
                  ....*....|....*....|....
gi 442628156 1479 -----RVAELETALRQANDAQKTA 1497
Cdd:PRK11281  249 ainskRLTLSEKTVQEAQSQDEAA 272
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
715-1205 2.08e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 55.93  E-value: 2.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  715 ALKQNELEDFQKKQSESEVHLQEIKAQNTQKDfELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKE-- 792
Cdd:COG4717    50 RLEKEADELFKPQGRKPELNLKELKELEEELK-EAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQll 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  793 ---QELQQLQSKSAESESALKVVqvqleqlqqqaaasgEEGSKTVAKLHDEISQLKSQAEETQSELKstqsnlEAKSKQL 869
Cdd:COG4717   129 plyQELEALEAELAELPERLEEL---------------EERLEELRELEEELEELEAELAELQEELE------ELLEQLS 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  870 EAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAAlEKVNKEYAESRAEAS--DLQDKVK 947
Cdd:COG4717   188 LATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALE-ERLKEARLLLLIAAAllALLGLGG 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  948 EITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAegerk 1027
Cdd:COG4717   267 SLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLE----- 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1028 eksFEESIKNLQEEVTKAKTENLELstgtqttikdLQERLEITNAELQHKEKMASED-----AQKIADLKTLVEAIQVAN 1102
Cdd:COG4717   342 ---LLDRIEELQELLREAEELEEEL----------QLEELEQEIAALLAEAGVEDEEelraaLEQAEEYQELKEELEELE 408

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1103 ANISATNAELSTVLEVLQAEKSETnhifELFEMEADMNS-----ERLIEKVTGIKEELK--ETHLQLDERQKKFEELEEK 1175
Cdd:COG4717   409 EQLEELLGELEELLEALDEEELEE----ELEELEEELEEleeelEELREELAELEAELEqlEEDGELAELLQELEELKAE 484

                         490       500       510
                  ....*....|....*....|....*....|
gi 442628156 1176 LKQAQQSEQKLQQESQTSKEKLTEIQQSLQ 1205
Cdd:COG4717   485 LRELAEEWAALKLALELLEEAREEYREERL 514
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 985-1243 2.82e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.77  E-value: 2.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  985 LTSKADAWSQEMLQKEKELQELRQQLQDSQdsqtKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELstgtQTTIKDLQ 1064
Cdd:COG4942    11 LALAAAAQADAAAEAEAELEQLQQEIAELE----KELAALKKEEKALLKQLAALERRIAALARRIRAL----EQELAALE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1065 ERLEITNAELQHKEKmaSEDAQKiADLKTLVEAIQvananisaTNAELSTVLEVLQAEKSetNHIFELFEMEADMNSERl 1144
Cdd:COG4942    83 AELAELEKEIAELRA--ELEAQK-EELAELLRALY--------RLGRQPPLALLLSPEDF--LDAVRRLQYLKYLAPAR- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1145 IEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEK 1224
Cdd:COG4942   149 REQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228

                         250
                  ....*....|....*....
gi 442628156 1225 VRESSSIIEAQNTKLNESN 1243
Cdd:COG4942   229 IARLEAEAAAAAERTPAAG 247
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
647-1121 2.85e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 55.54  E-value: 2.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  647 KSTLLEKTEKELVQSKEQAAKTLNdKEQLEKQISDLKQLAEQEKLVREMTEN--AINQIQLEKESIEQQLALKQNELEDF 724
Cdd:COG4717    36 KSTLLAFIRAMLLERLEKEADELF-KPQGRKPELNLKELKELEEELKEAEEKeeEYAELQEELEELEEELEELEAELEEL 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  725 QKKQSESEVHLQeikaqntqkdfeLVESGESLKKLQQQLEQktlghekLQAALEELKkeketiikEKEQELQQLQSKSAE 804
Cdd:COG4717   115 REELEKLEKLLQ------------LLPLYQELEALEAELAE-------LPERLEELE--------ERLEELRELEEELEE 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  805 SESALKVVQVQLEQLQQQAAASGEEgskTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKsg 884
Cdd:COG4717   168 LEAELAELQEELEELLEQLSLATEE---ELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALE-- 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  885 hllEQITKLKS--EVGETQAALSSCHTDVESKTKQLEAANAAL----------EKVNKEYAESRAEASDLQDKVKEITDT 952
Cdd:COG4717   243 ---ERLKEARLllLIAAALLALLGLGGSLLSLILTIAGVLFLVlgllallfllLAREKASLGKEAEELQALPALEELEEE 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  953 LHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQK--EKELQELRQQLQDSQDSQTKLKAEGERKEKS 1030
Cdd:COG4717   320 ELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEelEQEIAALLAEAGVEDEEELRAALEQAEEYQE 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1031 FEESIKNLQEEVTKAKTENLELSTGTQTTikDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQvANANISATNA 1110
Cdd:COG4717   400 LKEELEELEEQLEELLGELEELLEALDEE--ELEEELEELEEELEELEEELEELREELAELEAELEQLE-EDGELAELLQ 476

                         490
                  ....*....|.
gi 442628156 1111 ELSTVLEVLQA 1121
Cdd:COG4717   477 ELEELKAELRE 487
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 831-1055 3.28e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.38  E-value: 3.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  831 SKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTD 910
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  911 VESKTKQLEAANAALEKVNKEY-------AESRAEASDLQDKVKEITDTLHA---ELQAERSSSSALHTKLSKFSDEIAT 980
Cdd:COG4942    99 LEAQKEELAELLRALYRLGRQPplalllsPEDFLDAVRRLQYLKYLAPARREqaeELRADLAELAALRAELEAERAELEA 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442628156  981 GHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTG 1055
Cdd:COG4942   179 LLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALKG 253
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1119-1489 3.77e-07

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 54.90  E-value: 3.77e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1119 LQAEKSETNHIFELFEMeADMNSERLIEKVTGIKEELKETHLQLDERqkkFEELEEKLKQAQQSEQKLQQESQTSKEKLT 1198
Cdd:pfam07888   36 LEECLQERAELLQAQEA-ANRQREKEKERYKRDREQWERQRRELESR---VAELKEELRQSREKHEELEEKYKELSASSE 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1199 EIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLS 1278
Cdd:pfam07888  112 ELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLS 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1279 GELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKEL---QELLVKSQENEGNLqGESLAVTEKLQQLE 1355
Cdd:pfam07888  192 KEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELrslQERLNASERKVEGL-GEELSSMAAQRDRT 270

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1356 QAngELKEALCQkengLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERtlqeetSKLAEQLSQLKQANEELQKSL 1435
Cdd:pfam07888  271 QA--ELHQARLQ----AAQLTLQLADASLALREGRARWAQERETLQQSAEADK------DRIEKLSAELQRLEERLQEER 338

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 442628156  1436 QQKQLL-LEKGNEFD---TQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQ 1489
Cdd:pfam07888  339 MEREKLeVELGREKDcnrVQLSESRRELQELKASLRVAQKEKEQLQAEKQELLEYIRQ 396
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 465-748 4.67e-07

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 54.74  E-value: 4.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   465 QEEIAKLQEKMTIQQKevesRIAEQLEEEQRLRENVKYLNEQIATLqselVSKDEALEKFSLSECGIENLRRELELLKEE 544
Cdd:pfam17380  332 QAAIYAEQERMAMERE----RELERIRQEERKRELERIRQEEIAME----ISRMRELERLQMERQQKNERVRQELEAARK 403

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   545 NEKQAQEAQaeftRKLAEKSVEVLRLSSELQNLKATS-DSLESERVNktdECEILQTEVRMRDEQIRELNQQLDEvttql 623
Cdd:pfam17380  404 VKILEEERQ----RKIQQQKVEMEQIRAEQEEARQREvRRLEEERAR---EMERVRLEEQERQQQVERLRQQEEE----- 471

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   624 nvQKADSSALDDMLRLQKEGTEEKSTLLEKtekELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQI 703
Cdd:pfam17380  472 --RKRKKLELEKEKRDRKRAEEQRRKILEK---ELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQ 546

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 442628156   704 QL-EKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFE 748
Cdd:pfam17380  547 EMeERRRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAEYE 592
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 1132-1462 5.07e-07

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 54.47  E-value: 5.07e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1132 LFEMEADMNSERLIEkvtgIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQE----L 1207
Cdd:pfam06160   69 LFEAEELNDKYRFKK----AKKALDEIEELLDDIEEDIKQILEELDELLESEEKNREEVEELKDKYRELRKTLLAnrfsY 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1208 QDSVKQKEELVQNLEEK------VRESSSIIEAQNT--KLNESNVQLENKTS--------CLKETQDQLLESQKKEKQLQ 1271
Cdd:pfam06160  145 GPAIDELEKQLAEIEEEfsqfeeLTESGDYLEAREVleKLEEETDALEELMEdipplyeeLKTELPDQLEELKEGYREME 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1272 E-----EAAKLSGELQQVQEangDIKDSLVKVEEL-VKVLEEKLQAATSQLDAqqatnkeLQELLVKSQENEGNLQGESL 1345
Cdd:pfam06160  225 EegyalEHLNVDKEIQQLEE---QLEENLALLENLeLDEAEEALEEIEERIDQ-------LYDLLEKEVDAKKYVEKNLP 294

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1346 AVTEKLQQLEQANGELKE--ALCQKENGL--KELQgKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQL 1421
Cdd:pfam06160  295 EIEDYLEHAEEQNKELKEelERVQQSYTLneNELE-RVRGLEKQLEELEKRYDEIVERLEEKEVAYSELQEELEEILEQL 373

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 442628156  1422 SQLKQANEELQKSLQQkqllLEKGnEFDTQ--LAEYQKVIDEM 1462
Cdd:pfam06160  374 EEIEEEQEEFKESLQS----LRKD-ELEARekLDEFKLELREI 411
PRK12704 PRK12704
phosphodiesterase; Provisional
 672-804 7.57e-07

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 53.63  E-value: 7.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  672 KEQLEKQISDLKQLAEQeklvremtenAINQIQLEKESIEQQLALKQNELEDFQKKQSESEV-----HLQEIKAQNTQKD 746
Cdd:PRK12704   26 KKIAEAKIKEAEEEAKR----------ILEEAKKEAEAIKKEALLEAKEEIHKLRNEFEKELrerrnELQKLEKRLLQKE 95

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 442628156  747 FELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAE 804
Cdd:PRK12704   96 ENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISGLTAE 153
PRK12704 PRK12704
phosphodiesterase; Provisional
 1118-1277 7.84e-07

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 53.63  E-value: 7.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1118 VLQAEKsETNHIFELFEMEADMNSErliEKVTGIKEELK----ETHLQLDERQKKFEELEEKLkqaQQSEQKLQQESqts 1193
Cdd:PRK12704   33 IKEAEE-EAKRILEEAKKEAEAIKK---EALLEAKEEIHklrnEFEKELRERRNELQKLEKRL---LQKEENLDRKL--- 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1194 kEKLTEIQQSLQELQDSVKQKEELVQNLEEKVREsssIIEAQNTKLNE-SNVQLEnktsclkETQDQLLESQKKEkqLQE 1272
Cdd:PRK12704  103 -ELLEKREEELEKKEKELEQKQQELEKKEEELEE---LIEEQLQELERiSGLTAE-------EAKEILLEKVEEE--ARH 169


                  ....*
gi 442628156 1273 EAAKL 1277
Cdd:PRK12704  170 EAAVL 174
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1161-1483 8.29e-07

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 54.29  E-value: 8.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1161 QLDERQkkfeeLEEKLKQAQQSEQKLQQES----QTSKEKLTEIQQSL---QELQDSVKQKEELVQNLEEKVRESSSiiE 1233
Cdd:PRK10929   22 APDEKQ-----ITQELEQAKAAKTPAQAEIvealQSALNWLEERKGSLeraKQYQQVIDNFPKLSAELRQQLNNERD--E 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1234 AQNTKLNESNVQLENKtscLKETQDQLLEsqkkekqlqeeaakLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAAT 1313
Cdd:PRK10929   95 PRSVPPNMSTDALEQE---ILQVSSQLLE--------------KSRQAQQEQDRAREISDSLSQLPQQQTEARRQLNEIE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1314 SQLDAQQATNKELQELLVKSqenegnLQGESLAVTEKLQQLE---------QANGELKEALCQKENglKELQGKLDESNT 1384
Cdd:PRK10929  158 RRLQTLGTPNTPLAQAQLTA------LQAESAALKALVDELElaqlsannrQELARLRSELAKKRS--QQLDAYLQALRN 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1385 VLESQKkshneiQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSL-QQKQLLLEKGNEFDTQLAEYQKV----- 1458
Cdd:PRK10929  230 QLNSQR------QREAERALESTELLAEQSGDLPKSIVAQFKINRELSQALnQQAQRMDLIASQQRQAASQTLQVrqaln 303

                         330       340
                  ....*....|....*....|....*.
gi 442628156 1459 -IDEMDDAASVKSALLEQLQNRVAEL 1483
Cdd:PRK10929  304 tLREQSQWLGVSNALGEALRAQVARL 329
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1001-1448 9.99e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 53.62  E-value: 9.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1001 KELQELRQQLQDSQDSQTKLKAEGERKEKSfEESIKNLQEEVTKAKTENLELSTGTQttIKDLQERLEITNAELQHKEKM 1080
Cdd:COG4717    71 KELKELEEELKEAEEKEEEYAELQEELEEL-EEELEELEAELEELREELEKLEKLLQ--LLPLYQELEALEAELAELPER 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1081 ASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETnhifelfemeadmnSERLIEKVTGIKEELKETHL 1160
Cdd:COG4717   148 LEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEE--------------LQDLAEELEELQQRLAELEE 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1161 QLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQS-LQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKL 1239
Cdd:COG4717   214 ELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAaLLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLL 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1240 NESNVQLENKT------SCLKETQDQLLESQKKEKQLQ-----EEAAKLSGELQQVQEANGDIKD-----SLVKVEELVK 1303
Cdd:COG4717   294 AREKASLGKEAeelqalPALEELEEEELEELLAALGLPpdlspEELLELLDRIEELQELLREAEEleeelQLEELEQEIA 373

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1304 VL--------EEKLQAATSQLDAQQATNKELQELlvKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKEL 1375
Cdd:COG4717   374 ALlaeagvedEEELRAALEQAEEYQELKEELEEL--EEQLEELLGELEELLEALDEEELEEELEELEEELEELEEELEEL 451

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442628156 1376 QGKLDESNTVLESQKKShneiqDKLEQAQQKERTLQEETSKLAEQ---LSQLKQANEELQKSLQQKQL--LLEKGNEF 1448
Cdd:COG4717   452 REELAELEAELEQLEED-----GELAELLQELEELKAELRELAEEwaaLKLALELLEEAREEYREERLppVLERASEY 524
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 639-1434 1.13e-06

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 54.07  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  639 LQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLaeqeklvremtENAINQIQLEKESIEQQLALKQ 718
Cdd:PTZ00440  839 LQKFPTEDENLNLKELEKEFNENNQIVDNIIKDIENMNKNINIIKTL-----------NIAINRSNSNKQLVEHLLNNKI 907

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  719 NELEDFQKkqsesevHLQEIKAQN----TQKDFELVESGESLKKLQQQLEQKTLGHEKLQA--ALEELKKEKETIIKEKE 792
Cdd:PTZ00440  908 DLKNKLEQ-------HMKIINTDNiiqkNEKLNLLNNLNKEKEKIEKQLSDTKINNLKMQIekTLEYYDKSKENINGNDG 980

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  793 QELQQLQSKSAESEsALKVVQVQLEQLQQQAAASGEEgskTVAKLHDEISQLksqaeeTQSELKSTQSNLEAKSKQLEAa 872
Cdd:PTZ00440  981 THLEKLDKEKDEWE-HFKSEIDKLNVNYNILNKKIDD---LIKKQHDDIIEL------IDKLIKEKGKEIEEKVDQYIS- 1049

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  873 ngSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEItdt 952
Cdd:PTZ00440 1050 --LLEKMKTKLSSFHFNIDIKKYKNPKIKEEIKLLEEKVEALLKKIDENKNKLIEIKNKSHEHVVNADKEKNKQTEH--- 1124

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  953 lhaeLQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFE 1032
Cdd:PTZ00440 1125 ----YNKKKKSLEKIYKQMEKTLKELENMNLEDITLNEVNEIEIEYERILIDHIVEQINNEAKKSKTIMEEIESYKKDID 1200

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1033 ESIKNLQEEvTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKmaSEDAQKIADLKT--------LVEAIQVANAn 1104
Cdd:PTZ00440 1201 QVKKNMSKE-RNDHLTTFEYNAYYDKATASYENIEELTTEAKGLKGE--ANRSTNVDELKEiklqvfsyLQQVIKENNK- 1276

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1105 ISATNAELSTVLEVLQAEKSET------NHIFELFEMEADMNSErlIEKVTGIKEELKETHLQLDERQKKFEELEEKlKQ 1178
Cdd:PTZ00440 1277 MENALHEIKNMYEFLISIDSEKilkeilNSTKKAEEFSNDAKKE--LEKTDNLIKQVEAKIEQAKEHKNKIYGSLED-KQ 1353

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1179 AQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEE-KVRESSSIIEAQNTKLNESNVQLENKTSCLKETQ 1257
Cdd:PTZ00440 1354 IDDEIKKIEQIKEEISNKRKEINKYLSNIKSNKEKCDLHVRNASRgKDKIDFLNKHEAIEPSNSKEVNIIKITDNINKCK 1433

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1258 DQLLESQKKEKQLQEEAAKLsgeLQQVQEANGDIKDSLVKVEElvKVLEEKLQAATSQLDAQQATNKELQELLVKSQENE 1337
Cdd:PTZ00440 1434 QYSNEAMETENKADENNDSI---IKYEKEITNILNNSSILGKK--TKLEKKKKEATNIMDDINGEHSIIKTKLTKSSEKL 1508

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1338 GNLQ--------GESLA---VTEKLQQLEQANGELKEALCQKENGLKELQ----------------GKLDESNTvLESQK 1390
Cdd:PTZ00440 1509 NQLNeqpnikreGDVLNndkSTIAYETIQYNLGRVKHNLLNILNIKDEIEtilnkaqdlmrdiskiSKIVENKN-LENLN 1587

                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....
gi 442628156 1391 KSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKS 1434
Cdd:PTZ00440 1588 DKEADYVKYLDNILKEKQLMEAEYKKLNEIYSDVDNIEKELKKH 1631
46 PHA02562
endonuclease subunit; Provisional
 681-953 1.14e-06

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 53.48  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  681 DLKQLAEQEKL----VREMTENaINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAqntqkdfELVESGESL 756
Cdd:PHA02562  161 DISVLSEMDKLnkdkIRELNQQ-IQTLDMKIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYD-------ELVEEAKTI 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  757 KklqQQLEQktlghekLQAALEELKKEKEtiikEKEQELQQLQSKSAESESALKvvqvqleqlqqqaaasgeegskTVAK 836
Cdd:PHA02562  233 K---AEIEE-------LTDELLNLVMDIE----DPSAALNKLNTAAAKIKSKIE----------------------QFQK 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  837 L------HDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKsevgETQAALSSCHTD 910
Cdd:PHA02562  277 VikmyekGGVCPTCTQQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLL----ELKNKISTNKQS 352

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 442628156  911 VESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTL 953
Cdd:PHA02562  353 LITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKIVKTK 395
46 PHA02562
endonuclease subunit; Provisional
 1084-1300 1.18e-06

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 53.09  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1084 DAQKIADLKTLVEA-IQVANANISATNAELSTVLEVLqaeKSETNHIFELfEMEADMNSERLIEKVTGIKEELKETHLQL 1162
Cdd:PHA02562  161 DISVLSEMDKLNKDkIRELNQQIQTLDMKIDHIQQQI---KTYNKNIEEQ-RKKNGENIARKQNKYDELVEEAKTIKAEI 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1163 DERQKKFEELEE----------KLKQAQ-------QSEQKL--------------QQESQTsKEKLTEIQQSLQELQDSV 1211
Cdd:PHA02562  237 EELTDELLNLVMdiedpsaalnKLNTAAakikskiEQFQKVikmyekggvcptctQQISEG-PDRITKIKDKLKELQHSL 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1212 KQKEELVQNLEEKVREsssiIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDI 1291
Cdd:PHA02562  316 EKLDTAIDELEEIMDE----FNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKI 391


                  ....*....
gi 442628156 1292 KDSLVKVEE 1300
Cdd:PHA02562  392 VKTKSELVK 400
CLIP1_ZNF pfam16641
CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of ...
 1646-1662 1.29e-06

CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of the cytoplasmic linker protein CLIP1 (CLIP170). It forms a complex with the CAP-Gly domain of Dynactin.


Pssm-ID: 465212  Cd Length: 17  Bit Score: 45.92  E-value: 1.29e-06
                           10
                   ....*....|....*..
gi 442628156  1646 RKYCDSCEVFGHDTSEC 1662
Cdd:pfam16641    1 RPYCEICEVFGHDTEDC 17
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 846-1072 1.42e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.46  E-value: 1.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  846 SQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAAL 925
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  926 EKVNKEYAEsRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQE 1005
Cdd:COG4942   100 EAQKEELAE-LLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEA 178

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442628156 1006 LRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEITNA 1072
Cdd:COG4942   179 LLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
486-733 1.54e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 53.10  E-value: 1.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  486 IAEQLEEEQ-RLRENVKYLNEQIATLQSELVSKDEALEKFslsecgienlrrelelLKEENEKQAQEAQAEFTRKLAEKS 564
Cdd:COG3206   162 LEQNLELRReEARKALEFLEEQLPELRKELEEAEAALEEF----------------RQKNGLVDLSEEAKLLLQQLSELE 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  565 VEVLRLSSELQNLKATSDSLESERVNKTDECEILQTevrmrDEQIRELNQQLDEVTTQLNVQKADSSALD-DMLRLQKEG 643
Cdd:COG3206   226 SQLAEARAELAEAEARLAALRAQLGSGPDALPELLQ-----SPVIQQLRAQLAELEAELAELSARYTPNHpDVIALRAQI 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  644 TEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQeklvremtenaINQIQLEKESIEQQLALKQNELED 723
Cdd:COG3206   301 AALRAQLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAE-----------LPELEAELRRLEREVEVARELYES 369

                         250
                  ....*....|
gi 442628156  724 FQKKQSESEV 733
Cdd:COG3206   370 LLQRLEEARL 379
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1153-1440 1.57e-06

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 51.84  E-value: 1.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1153 EELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSII 1232
Cdd:COG1340     1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1233 EAQNTKLNESNVQLENktscLKETQDQLLESQKKEKQLQEEAAKLSGElQQVQEANGDIKDSLVkveELVKVLEEKLQAA 1312
Cdd:COG1340    81 DELNEKLNELREELDE----LRKELAELNKAGGSIDKLRKEIERLEWR-QQTEVLSPEEEKELV---EKIKELEKELEKA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1313 TSQLDAqqatNKELQELLvksqenegnlqGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKS 1392
Cdd:COG1340   153 KKALEK----NEKLKELR-----------AELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADELRKEADELHKE 217

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 442628156 1393 HNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQL 1440
Cdd:COG1340   218 IVEAQEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEKEEL 265
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1172-1407 1.60e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 53.10  E-value: 1.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1172 LEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELqdsvKQKEELVqNLEEKVRESSSIIEAQNTKLNESNVQLENKTS 1251
Cdd:COG3206   166 LELRREEARKALEFLEEQLPELRKELEEAEAALEEF----RQKNGLV-DLSEEAKLLLQQLSELESQLAEARAELAEAEA 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1252 CLKETQDQLLESQKKEKQLQEEAAkLSGELQQVQEANGDIKDSLVKVEE---LVKVLEEKLQAATSQLDAqqatnkELQE 1328
Cdd:COG3206   241 RLAALRAQLGSGPDALPELLQSPV-IQQLRAQLAELEAELAELSARYTPnhpDVIALRAQIAALRAQLQQ------EAQR 313

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442628156 1329 LLVksqenegNLQGESLAVTEKLQQLEQANGELKEALcqkeNGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKE 1407
Cdd:COG3206   314 ILA-------SLEAELEALQAREASLQAQLAQLEARL----AELPELEAELRRLEREVEVARELYESLLQRLEEARLAE 381
PRK11281 PRK11281
mechanosensitive channel MscK;
392-802 2.34e-06

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 52.61  E-value: 2.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  392 ELESALD--NERKKTEE----LQCSIDEAQfcgdELNAQSQVYKEKIHDLESKITKlvsATPSLQSIlppdlpsddgalQ 465
Cdd:PRK11281   40 DVQAQLDalNKQKLLEAedklVQQDLEQTL----ALLDKIDRQKEETEQLKQQLAQ---APAKLRQA------------Q 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  466 EEIAKLQEKM---------TIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSelvskdealekfslsecgienlrr 536
Cdd:PRK11281  101 AELEALKDDNdeetretlsTLSLRQLESRLAQTLDQLQNAQNDLAEYNSQLVSLQT------------------------ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  537 elellkeenekQAQEAQAEftrkLAEKSVEVLRLSSELQNLKATSDSLESERVNKtdeceiLQTEVRMRDEQIrELNQQL 616
Cdd:PRK11281  157 -----------QPERAQAA----LYANSQRLQQIRNLLKGGKVGGKALRPSQRVL------LQAEQALLNAQN-DLQRKS 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  617 DEVTTQLNvqkadssaldDMLRLQKEGTEEKSTLLEKT---------EKELVQSKEQAAKTLNDKE------------QL 675
Cdd:PRK11281  215 LEGNTQLQ----------DLLQKQRDYLTARIQRLEHQlqllqeainSKRLTLSEKTVQEAQSQDEaariqanplvaqEL 284

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  676 E--KQISD--------LKQLAEQEKLVREMTENAINQIQLEKESI--------------EQQLALKQNEL-EDFQKKQSE 730
Cdd:PRK11281  285 EinLQLSQrllkatekLNTLTQQNLRVKNWLDRLTQSERNIKEQIsvlkgslllsrilyQQQQALPSADLiEGLADRIAD 364

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  731 SEVHLQEIkaqNTQKDfELVESGESLKKLQQQleQKTLGHEKLQAALEELKKEKETIIKEKEQEL--------------Q 796
Cdd:PRK11281  365 LRLEQFEI---NQQRD-ALFQPDAYIDKLEAG--HKSEVTDEVRDALLQLLDERRELLDQLNKQLnnqlnlainlqlnqQ 438


                  ....*.
gi 442628156  797 QLQSKS 802
Cdd:PRK11281  439 QLLSVS 444
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 442-690 2.60e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.69  E-value: 2.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  442 LVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMtiqqKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEAL 521
Cdd:COG4942    10 LLALAAAAQADAAAEAEAELEQLQQEIAELEKEL----AALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAEL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  522 EKFSLSEcgienlrrelellkeeneKQAQEAQAEFTRKLAEKSVEVLRLS--SELQNLKATSDSLESERVNktdecEILQ 599
Cdd:COG4942    86 AELEKEI------------------AELRAELEAQKEELAELLRALYRLGrqPPLALLLSPEDFLDAVRRL-----QYLK 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  600 TEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKE-------GTEEKSTLLEKTEKELVQSKEQAAKTLNDK 672
Cdd:COG4942   143 YLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEeraaleaLKAERQKLLARLEKELAELAAELAELQQEA 222

                         250
                  ....*....|....*...
gi 442628156  673 EQLEKQISDLKQLAEQEK 690
Cdd:COG4942   223 EELEALIARLEAEAAAAA 240
PRK09039 PRK09039
peptidoglycan -binding protein;
597-736 3.19e-06

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 51.12  E-value: 3.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  597 ILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDML-RLQKEgteekstlLEKTEKELVQSKEQAAKTLNDKEQL 675
Cdd:PRK09039   43 FLSREISGKDSALDRLNSQIAELADLLSLERQGNQDLQDSVaNLRAS--------LSAAEAERSRLQALLAELAGAGAAA 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442628156  676 EKQISDL-KQLAEQEKLvremTENAINQIQLEKESIEQ---QLALKQNELEDFQKKQSESEVHLQ 736
Cdd:PRK09039  115 EGRAGELaQELDSEKQV----SARALAQVELLNQQIAAlrrQLAALEAALDASEKRDRESQAKIA 175
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1253-1498 3.28e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 51.37  E-value: 3.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1253 LKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQAtnkELQELLVK 1332
Cdd:COG3883    18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERRE---ELGERARA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1333 SQENEGNLQgeslavteKLQQLEQANGelkealcqkengLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQE 1412
Cdd:COG3883    95 LYRSGGSVS--------YLDVLLGSES------------FSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1413 ETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQAND 1492
Cdd:COG3883   155 KLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAA 234


                  ....*.
gi 442628156 1493 AQKTAY 1498
Cdd:COG3883   235 AAAAAA 240
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 559-805 3.40e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.30  E-value: 3.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  559 KLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLR 638
Cdd:COG4942    21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  639 LQKEgteEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQeklvREMTENAINQIQLEKESIEQQLALKQ 718
Cdd:COG4942   101 AQKE---ELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPA----RREQAEELRADLAELAALRAELEAER 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  719 NELEDFQKKQSESEVHLQEIKAQNTQKdfelvesgesLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQL 798
Cdd:COG4942   174 AELEALLAELEEERAALEALKAERQKL----------LARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERT 243


                  ....*..
gi 442628156  799 QSKSAES 805
Cdd:COG4942   244 PAAGFAA 250
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1048-1529 4.20e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 51.76  E-value: 4.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1048 ENLELSTGTQ-TTIKDLQERLEITNAE--LQHKEKMASEDAQKIADLKTlVEAIQVANA--------NISATNAELSTVL 1116
Cdd:pfam12128  149 QNDRTLLGRErVELRSLARQFALCDSEspLRHIDKIAKAMHSKEGKFRD-VKSMIVAILeddgvvppKSRLNRQQVEHWI 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1117 EVLQAEKSETNHIFELFEMEADMNS-ERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQaqqseqKLQQESQTSKE 1195
Cdd:pfam12128  228 RDIQAIAGIMKIRPEFTKLQQEFNTlESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQ------LLRTLDDQWKE 301

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1196 KLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIiEAQNTKLNESNV-QLENKTSCLKETQDQLLESQ---------K 1265
Cdd:pfam12128  302 KRDELNGELSAADAAVAKDRSELEALEDQHGAFLDA-DIETAAADQEQLpSWQSELENLEERLKALTGKHqdvtakynrR 380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1266 KEKQLQEEAAKLSGeLQQVQEANGDIKDSLVKVEElvKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESL 1345
Cdd:pfam12128  381 RSKIKEQNNRDIAG-IKDKLAKIREARDRQLAVAE--DDLQALESELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQAT 457

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1346 AVTEKLQQLEQANGEL---KEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQL- 1421
Cdd:pfam12128  458 ATPELLLQLENFDERIeraREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQLFPQAGTLl 537

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1422 ----SQLKQANEELQKSLQQKQLLlekgnefdtqlaeyQKVIDEMDDAASVKSAL--------LEQLQ-NRVAELETALR 1488
Cdd:pfam12128  538 hflrKEAPDWEQSIGKVISPELLH--------------RTDLDPEVWDGSVGGELnlygvkldLKRIDvPEWAASEEELR 603

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 442628156  1489 QANDAQKTAYLETKELRRQLESLELEKSREVLSLKAQMNGA 1529
Cdd:pfam12128  604 ERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFA 644
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
637-1068 4.47e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 51.31  E-value: 4.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  637 LRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKEsiEQQLAL 716
Cdd:COG4717    83 AEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEER--LEELRE 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  717 KQNELEDFQKKQSESEVHLQEIKAQNT-QKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKE--Q 793
Cdd:COG4717   161 LEEELEELEAELAELQEELEELLEQLSlATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEaaA 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  794 ELQQLQSK--SAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEA 871
Cdd:COG4717   241 LEERLKEArlLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEE 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  872 ANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVES-KTKQLEAANAALEK----VNKEYAESRAEASDLQDKV 946
Cdd:COG4717   321 LEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEElQLEELEQEIAALLAeagvEDEEELRAALEQAEEYQEL 400

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  947 KEITDTLHAELQAERSSSSALHTKLSKfsDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGER 1026
Cdd:COG4717   401 KEELEELEEQLEELLGELEELLEALDE--EELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGELAELLQEL 478

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 442628156 1027 KEKsfEESIKNLQEEVTKAKTenlelstgTQTTIKDLQERLE 1068
Cdd:COG4717   479 EEL--KAELRELAEEWAALKL--------ALELLEEAREEYR 510
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 672-809 4.48e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 49.92  E-value: 4.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  672 KEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQS------ESEVHLQEIKAQNTQK 745
Cdd:COG1579    26 LKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGnvrnnkEYEALQKEIESLKRRI 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442628156  746 DF---ELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESAL 809
Cdd:COG1579   106 SDledEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAKI 172
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1183-1439 4.49e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 51.56  E-value: 4.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1183 EQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLeekvRESSSIIEAQNtklnESNVQLENktscLKETQDQLLE 1262
Cdd:COG3206   163 EQNLELRREEARKALEFLEEQLPELRKELEEAEAALEEF----RQKNGLVDLSE----EAKLLLQQ----LSELESQLAE 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1263 SQKKEKQLQEEAAKLSGELQQVQEANGDIKDSlvkveELVKVLEEKLQAATSQLDAQQATNKElqellvksqenegnlqg 1342
Cdd:COG3206   231 ARAELAEAEARLAALRAQLGSGPDALPELLQS-----PVIQQLRAQLAELEAELAELSARYTP----------------- 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1343 ESLAVTEKLQQLEQANGELKEalcqkenglkELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEqLS 1422
Cdd:COG3206   289 NHPDVIALRAQIAALRAQLQQ----------EAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRR-LE 357

                         250
                  ....*....|....*..
gi 442628156 1423 QLKQANEELQKSLQQKQ 1439
Cdd:COG3206   358 REVEVARELYESLLQRL 374
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1255-1423 4.91e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 49.54  E-value: 4.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1255 ETQDQLLESQKKEKQLQE---EAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELL- 1330
Cdd:COG1579     4 EDLRALLDLQELDSELDRlehRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLg 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1331 -VKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKshnEIQDKLEQAQQKERT 1409
Cdd:COG1579    84 nVRNNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKA---ELDEELAELEAELEE 160

                         170
                  ....*....|....
gi 442628156 1410 LQEETSKLAEQLSQ 1423
Cdd:COG1579   161 LEAEREELAAKIPP 174
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 560-896 5.01e-06

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 51.36  E-value: 5.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   560 LAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRL 639
Cdd:pfam10174  361 LNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTT 440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   640 QKEGTEEKSTLLEKTEKELVQSKEQAAKTLndkEQLEKQISDLKQ--------LAEQEKLVREMTENAINQIQ--LEKES 709
Cdd:pfam10174  441 LEEALSEKERIIERLKEQREREDRERLEEL---ESLKKENKDLKEkvsalqpeLTEKESSLIDLKEHASSLASsgLKKDS 517

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   710 ieqqlALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFEL-VESGESLKKLQQQLEQKTLGHEKLQAALEEL-------- 780
Cdd:pfam10174  518 -----KLKSLEIAVEQKKEECSKLENQLKKAHNAEEAVRTnPEINDRIRLLEQEVARYKEESGKAQAEVERLlgilreve 592

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   781 --KKEKETIIKE---------KEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAE 849
Cdd:pfam10174  593 neKNDKDKKIAElesltlrqmKEQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQLEELMGALEKTRQELD 672

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 442628156   850 ETQSELKSTQSNLEAKSKQLEaangSLEEEAKKSghlLEQITKLKSE 896
Cdd:pfam10174  673 ATKARLSSTQQSLAEKDGHLT----NLRAERRKQ---LEEILEMKQE 712
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 391-1414 5.72e-06

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 51.76  E-value: 5.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  391 VELESALDNERKKTEELQCSIDEAQFCGDELNAQSQ---VYKEKIHDLESKITKLVSATP-SLQSILppDLPSDDGA--- 463
Cdd:PTZ00440  487 EKKESSDSNYQEKVDELLQIINSIKEKNNIVNNNFKnieDYYITIEGLKNEIEGLIELIKyYLQSIE--TLIKDEKLkrs 564

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  464 LQEEIAK-----------------LQEKMTIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSL 526
Cdd:PTZ00440  565 MKNDIKNkikyieenvdhikdiisLNDEIDNIIQQIEELINEALFNKEKFINEKNDLQEKVKYILNKFYKGDLQELLDEL 644

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  527 SECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVL-----RLSSELQNLKATSDSLESERVNKtdeceiLQTE 601
Cdd:PTZ00440  645 SHFLDDHKYLYHEAKSKEDLQTLLNTSKNEYEKLEFMKSDNIdniikNLKKELQNLLSLKENIIKKQLNN------IEQD 718

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  602 VRMRDEQIRElnqQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQL---EKQ 678
Cdd:PTZ00440  719 ISNSLNQYTI---KYNDLKSSIEEYKEEEEKLEVYKHQIINRKNEFILHLYENDKDLPDGKNTYEEFLQYKDTIlnkENK 795

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  679 IS-DLKQLAEQEKLVREMTENAINQIQLEK-------ESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELV 750
Cdd:PTZ00440  796 ISnDINILKENKKNNQDLLNSYNILIQKLEahtekndEELKQLLQKFPTEDENLNLKELEKEFNENNQIVDNIIKDIENM 875

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  751 ESG-ESLKKLQQQLEqktlGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESAlkvvqvqleqLQQQAAASGEE 829
Cdd:PTZ00440  876 NKNiNIIKTLNIAIN----RSNSNKQLVEHLLNNKIDLKNKLEQHMKIINTDNIIQKNE----------KLNLLNNLNKE 941

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  830 GSKTVAKLHDE-ISQLKSQAEETQSELKSTQSNLEAKSK-QLEaangSLEEEAKKSGHLLEQITKLKSEVGETQAALSSc 907
Cdd:PTZ00440  942 KEKIEKQLSDTkINNLKMQIEKTLEYYDKSKENINGNDGtHLE----KLDKEKDEWEHFKSEIDKLNVNYNILNKKIDD- 1016

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  908 hTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTS 987
Cdd:PTZ00440 1017 -LIKKQHDDIIELIDKLIKEKGKEIEEKVDQYISLLEKMKTKLSSFHFNIDIKKYKNPKIKEEIKLLEEKVEALLKKIDE 1095

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  988 KADAWSQEMLQKEKELQELRQQLQdsqdsqtKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTqttikdlqerl 1067
Cdd:PTZ00440 1096 NKNKLIEIKNKSHEHVVNADKEKN-------KQTEHYNKKKKSLEKIYKQMEKTLKELENMNLEDITLN----------- 1157

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1068 EITNAELQHKEKMASEDAQKIAD-----------LKTLVEAIQVANANISATNAELSTVLEVLQAEKSETnhifelfemE 1136
Cdd:PTZ00440 1158 EVNEIEIEYERILIDHIVEQINNeakksktimeeIESYKKDIDQVKKNMSKERNDHLTTFEYNAYYDKAT---------A 1228

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1137 ADMNSERLIEKVTGIKEElkethlqlDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQ------------QSL 1204
Cdd:PTZ00440 1229 SYENIEELTTEAKGLKGE--------ANRSTNVDELKEIKLQVFSYLQQVIKENNKMENALHEIKnmyeflisidseKIL 1300

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1205 QELQDSVKQKEELVQNLEEKVRESSSIIEaqntklnesnvQLENKTSCLKETQDQLLESQkKEKQLQEEAAKLSGELQQV 1284
Cdd:PTZ00440 1301 KEILNSTKKAEEFSNDAKKELEKTDNLIK-----------QVEAKIEQAKEHKNKIYGSL-EDKQIDDEIKKIEQIKEEI 1368

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1285 QEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEklQQLEQANGELKEA 1364
Cdd:PTZ00440 1369 SNKRKEINKYLSNIKSNKEKCDLHVRNASRGKDKIDFLNKHEAIEPSNSKEVNIIKITDNINKCK--QYSNEAMETENKA 1446

                        1050      1060      1070      1080      1090      1100
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442628156 1365 LCQKENGLK-------------------ELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEET 1414
Cdd:PTZ00440 1447 DENNDSIIKyekeitnilnnssilgkktKLEKKKKEATNIMDDINGEHSIIKTKLTKSSEKLNQLNEQP 1515
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
 1219-1501 6.28e-06

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 51.31  E-value: 6.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1219 QNLEEKvresssiIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQlqeeaAKLSGELQQVQEANGDIKDSLVKV 1298
Cdd:pfam18971  559 RNLENK-------LTAKGLSLQEANKLIKDFLSSNKELAGKALNFNKAVAE-----AKSTGNYDEVKKAQKDLEKSLRKR 626

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1299 EELVKVLEEKLQAAT---SQLDAQQATNKELQEL--LVKSQENEG--------NLQGESLAVTEKLQQLEQANGELKEAL 1365
Cdd:pfam18971  627 EHLEKEVEKKLESKSgnkNKMEAKAQANSQKDEIfaLINKEANRDaraiaytqNLKGIKRELSDKLEKISKDLKDFSKSF 706

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1366 CQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLqqKQLLLEkg 1445
Cdd:pfam18971  707 DEFKNGKNKDFSKAEETLKALKGSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVTQAKSDLENSV--KDVIIN-- 782

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442628156  1446 nefdtqlaeyQKVIDEMDD---AASVKSAL--LEQLQNRVAELETALRQ--ANDAQKTAYLET 1501
Cdd:pfam18971  783 ----------QKVTDKVDNlnqAVSVAKAMgdFSRVEQVLADLKNFSKEqlAQQAQKNEDFNT 835
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 738-1374 8.54e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 50.88  E-value: 8.54e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   738 IKAQNTQKD--FELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQ 815
Cdd:pfam05483  204 VQAENARLEmhFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDEN 283

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   816 LEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSleeeakKSGHLLeQITKLKS 895
Cdd:pfam05483  284 LKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKA------KAAHSF-VVTEFEA 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   896 EVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLhaelqAERSSSSALHTKLSKFS 975
Cdd:pfam05483  357 TTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELKKIL-----AEDEKLLDEKKQFEKIA 431

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   976 DEIATGHKELTSKADAwsqemlqKEKELQELRQQLQDSQDSqtklkaegerkEKSFEESIKNLQEEVTKAKTENLELSTG 1055
Cdd:pfam05483  432 EELKGKEQELIFLLQA-------REKEIHDLEIQLTAIKTS-----------EEHYLKEVEDLKTELEKEKLKNIELTAH 493

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1056 tqttikdlqerleiTNAELQHKEKMASEDAQKIADLKTLVEAIqvananISATNAELSTVLEVLQAEKSETNhifelFEM 1135
Cdd:pfam05483  494 --------------CDKLLLENKELTQEASDMTLELKKHQEDI------INCKKQEERMLKQIENLEEKEMN-----LRD 548

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1136 EADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKE 1215
Cdd:pfam05483  549 ELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAEN 628

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1216 ELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQqvQEANGDIKDSL 1295
Cdd:pfam05483  629 KQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVKLQKEID--KRCQHKIAEMV 706

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442628156  1296 VKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKE 1374
Cdd:pfam05483  707 ALMEKHKHQYDKIIEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTAILKD 785
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
685-906 9.65e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 50.40  E-value: 9.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  685 LAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFqkKQSESEVHLQEIKAQNTQKdfelvesgesLKKLQQQLE 764
Cdd:COG3206   162 LEQNLELRREEARKALEFLEEQLPELRKELEEAEAALEEF--RQKNGLVDLSEEAKLLLQQ----------LSELESQLA 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  765 QKTLGHEKLQAALEELKKEKETIIKE-----KEQELQQLQSKSAESESALKVVQVQLEqlqqqaaasgeEGSKTVAKLHD 839
Cdd:COG3206   230 EARAELAEAEARLAALRAQLGSGPDAlpellQSPVIQQLRAQLAELEAELAELSARYT-----------PNHPDVIALRA 298

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442628156  840 EISQLKSQ----AEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSS 906
Cdd:COG3206   299 QIAALRAQlqqeAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYES 369
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
351-783 1.19e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 50.45  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  351 LREKQQHVEKlMVERDLDREDAQNQALQLQKNINELKAR-----IVELESALDNERKKTEELQCSIDEaqfcgdelnaqs 425
Cdd:PRK03918  343 LKKKLKELEK-RLEELEERHELYEEAKAKKEELERLKKRltgltPEKLEKELEELEKAKEEIEEEISK------------ 409

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  426 qvYKEKIHDLESKITKLVSATPSLQSIlPPDLPSDDGALQEEIAK-LQEKMTIQQKEVESRIAEQLEEEQRLRENVKYLn 504
Cdd:PRK03918  410 --ITARIGELKKEIKELKKAIEELKKA-KGKCPVCGRELTEEHRKeLLEEYTAELKRIEKELKEIEEKERKLRKELREL- 485

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  505 EQIATLQSELVSKDEALEKfslsecgIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSEL---QNLKATS 581
Cdd:PRK03918  486 EKVLKKESELIKLKELAEQ-------LKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELeklEELKKKL 558

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  582 DSLESERVNKTDECEILQTEVRMRD-EQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEgteekstlLEKTEKELVQ 660
Cdd:PRK03918  559 AELEKKLDELEEELAELLKELEELGfESVEELEERLKELEPFYNEYLELKDAEKELEREEKE--------LKKLEEELDK 630

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  661 SKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVRemtenainqIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKA 740
Cdd:PRK03918  631 AFEELAETEKRLEELRKELEELEKKYSEEEYEE---------LREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKE 701

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 442628156  741 QNTqkdfELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKE 783
Cdd:PRK03918  702 ELE----EREKAKKELEKLEKALERVEELREKVKKYKALLKER 740
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1160-1351 1.37e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 48.38  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1160 LQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSsiiEAQNTKL 1239
Cdd:COG1579    10 LDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYE---EQLGNVR 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1240 NESNVQlenktSCLKEtqdqlLESQKKEKQLQEEaaklsgELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQ 1319
Cdd:COG1579    87 NNKEYE-----ALQKE-----IESLKRRISDLED------EILELMERIEELEEELAELEAELAELEAELEEKKAELDEE 150

                         170       180       190
                  ....*....|....*....|....*....|...
gi 442628156 1320 QA-TNKELQELLVKSQENEGNLQGESLAVTEKL 1351
Cdd:COG1579   151 LAeLEAELEELEAEREELAAKIPPELLALYERI 183
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 674-810 1.38e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 48.38  E-value: 1.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  674 QLEKQISDL-KQLAEQEKLVREMtENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKaqnTQKDFELVES 752
Cdd:COG1579    21 RLEHRLKELpAELAELEDELAAL-EARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVR---NNKEYEALQK 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442628156  753 G-ESLKKLQQQLEQKTLGH----EKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALK 810
Cdd:COG1579    97 EiESLKRRISDLEDEILELmeriEELEEELAELEAELAELEAELEEKKAELDEELAELEAELE 159
PRK12704 PRK12704
phosphodiesterase; Provisional
 1147-1331 1.43e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 49.78  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1147 KVTGIKEELKEThlqLDERQKKFEEL-EEKLKQAQQSEQKLQQE-SQTSKEKLTEIQQslqeLQDSVKQKEELVQNLEEK 1224
Cdd:PRK12704   32 KIKEAEEEAKRI---LEEAKKEAEAIkKEALLEAKEEIHKLRNEfEKELRERRNELQK----LEKRLLQKEENLDRKLEL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1225 VRESSSIIEAQNTKLNESNVQLENKtsclKETQDQLLESQKKEkqlQEEAAKLSGElqqvqEANgdikdslvkvEELVKV 1304
Cdd:PRK12704  105 LEKREEELEKKEKELEQKQQELEKK----EEELEELIEEQLQE---LERISGLTAE-----EAK----------EILLEK 162

                         170       180       190
                  ....*....|....*....|....*....|...
gi 442628156 1305 LEEKLQAATSQL------DAQQATNKELQELLV 1331
Cdd:PRK12704  163 VEEEARHEAAVLikeieeEAKEEADKKAKEILA 195
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1081-1322 1.65e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.99  E-value: 1.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1081 ASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQaeksetnhifelfemEADMNSERLIEKVTGIKEELKETHL 1160
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLA---------------ALERRIAALARRIRALEQELAALEA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1161 QLDERQKKFEELEEKLKQAQQSEQK----LQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVREsssiIEAQN 1236
Cdd:COG4942    84 ELAELEKEIAELRAELEAQKEELAEllraLYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEE----LRADL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1237 TKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQL 1316
Cdd:COG4942   160 AELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239


                  ....*.
gi 442628156 1317 DAQQAT 1322
Cdd:COG4942   240 AERTPA 245
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1172-1447 1.65e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 49.13  E-value: 1.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1172 LEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTS 1251
Cdd:COG4372    29 LSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQE 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1252 CLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLV 1331
Cdd:COG4372   109 EAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDEL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1332 KSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQ 1411
Cdd:COG4372   189 LKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAIL 268

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 442628156 1412 EETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNE 1447
Cdd:COG4372   269 VEKDTEEEELEIAALELEALEEAALELKLLALLLNL 304
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 350-949 1.78e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 49.66  E-value: 1.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   350 LLREKQQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVE--LESALDNERKKTEELQCSIDEAQFCGDELNAQSQV 427
Cdd:TIGR00606  369 LIQSLATRLELDGFERGPFSERQIKNFHTLVIERQEDEAKTAAqlCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEI 448

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   428 YKEKIHDLESKITKLVSATPSLQSILppdlpsddgalqeeiaKLQEKMTiqQKEVESRIAEQLEEEQRLRENVKYLNEQI 507
Cdd:TIGR00606  449 LEKKQEELKFVIKELQQLEGSSDRIL----------------ELDQELR--KAERELSKAEKNSLTETLKKEVKSLQNEK 510

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   508 ATLQSELVSKDEALEKfslsecgiENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESE 587
Cdd:TIGR00606  511 ADLDRKLRKLDQEMEQ--------LNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSK 582

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   588 RVnktdecEILQTEVRMRDEQ--IRELNQQLDEVTTQLNVQKADSSALDDMLrLQKEGTEEKSTLLEKTEKELVQSKEQA 665
Cdd:TIGR00606  583 SK------EINQTRDRLAKLNkeLASLEQNKNHINNELESKEEQLSSYEDKL-FDVCGSQDEESDLERLKEEIEKSSKQR 655

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   666 AKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQK 745
Cdd:TIGR00606  656 AMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGR 735

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   746 DFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQE---------LQQLQSKSAESESalKVVQVQL 816
Cdd:TIGR00606  736 QSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAkvcltdvtiMERFQMELKDVER--KIAQQAA 813

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   817 EQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQ---SNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKL 893
Cdd:TIGR00606  814 KLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQeqiQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVEL 893

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   894 KSEVGETQAALSSCHT----DVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEI 949
Cdd:TIGR00606  894 STEVQSLIREIKDAKEqdspLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNI 953
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 357-1240 1.98e-05

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 49.45  E-value: 1.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   357 HVEKL---MVERDLDREDAQNQalqlqknineLKARIVELESALDNERKKTEELQCSIDEAQfcgdeLNAQSQVYKEKIH 433
Cdd:pfam12128  180 HIDKIakaMHSKEGKFRDVKSM----------IVAILEDDGVVPPKSRLNRQQVEHWIRDIQ-----AIAGIMKIRPEFT 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   434 DLESKITKLVSATPSLQSilppdlpsddgaLQEEIAKLQEKMTIQQKEVESRIAEQleeEQRLRENVKYLNEQIATLQSE 513
Cdd:pfam12128  245 KLQQEFNTLESAELRLSH------------LHFGYKSDETLIASRQEERQETSAEL---NQLLRTLDDQWKEKRDELNGE 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   514 LVSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERV--NK 591
Cdd:pfam12128  310 LSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKeqNN 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   592 TDECEILQTEVRMRDEQIRelnqqldevttQLNVQKADSSALDDMLRLQKEGT----EEKSTLLEKTEKELVQSKEQAAK 667
Cdd:pfam12128  390 RDIAGIKDKLAKIREARDR-----------QLAVAEDDLQALESELREQLEAGklefNEEEYRLKSRLGELKLRLNQATA 458

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   668 TLNDKEQLEKQISDLKQLAE-QEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKD 746
Cdd:pfam12128  459 TPELLLQLENFDERIERAREeQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQLFPQAGTLLH 538

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   747 FELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQsksaesesalkvvqvqleqlqqqaaas 826
Cdd:pfam12128  539 FLRKEAPDWEQSIGKVISPELLHRTDLDPEVWDGSVGGELNLYGVKLDLKRID--------------------------- 591

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   827 geegsktVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKsghLLEQITKLKSEvGETQAALSS 906
Cdd:pfam12128  592 -------VPEWAASEEELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASRE---ETFARTALKNA-RLDLRRLFD 660

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   907 CHTDVESK-TKQLEAANA-ALEKVNKEYAESRAEASDLQDKVKEITDTL----HAELQAERSSSSALHTKLSKFSDEIA- 979
Cdd:pfam12128  661 EKQSEKDKkNKALAERKDsANERLNSLEAQLKQLDKKHQAWLEEQKEQKrearTEKQAYWQVVEGALDAQLALLKAAIAa 740

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   980 --TGHKELTSKADAWSQEMLQK-----------EKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAK 1046
Cdd:pfam12128  741 rrSGAKAELKALETWYKRDLASlgvdpdviaklKREIRTLERKIERIAVRRQEVLRYFDWYQETWLQRRPRLATQLSNIE 820

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1047 TENLELstgtQTTIKDLQERLEITNAELQhKEKMASEDAQ---------------KIADLKTLVEAIQvANANISATNAE 1111
Cdd:pfam12128  821 RAISEL----QQQLARLIADTKLRRAKLE-MERKASEKQQvrlsenlrglrcemsKLATLKEDANSEQ-AQGSIGERLAQ 894

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1112 LSTVLEVLQAEKSETNHIFELFEM--------EADMNSERLIEKVTGIKEELkethLQLDERQKKFEELEEKLK-QAQQS 1182
Cdd:pfam12128  895 LEDLKLKRDYLSESVKKYVEHFKNviadhsgsGLAETWESLREEDHYQNDKG----IRLLDYRKLVPYLEQWFDvRVPQS 970

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442628156  1183 EQKLQQESQTSKEKLTEIQQSLQELQDSVK-QKEELVQNLE-----EKVRESSSIIEAQNTKLN 1240
Cdd:pfam12128  971 IMVLREQVSILGVDLTEFYDVLADFDRRIAsFSRELQREVGeeaffEGVSESAVRIRSKVSELE 1034
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
351-795 2.05e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 49.38  E-value: 2.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  351 LREKQQHVEKLMVERDlDREDAQNQALQLQKNINELKARIVELESALDNER--KKTEELQCSIDEAQFCGDELNAQSQVY 428
Cdd:COG4717    80 LKEAEEKEEEYAELQE-ELEELEEELEELEAELEELREELEKLEKLLQLLPlyQELEALEAELAELPERLEELEERLEEL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  429 KEKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQekmtiqqkEVESRIAEQLEEEQRLRENVKYLNEQIA 508
Cdd:COG4717   159 RELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELE--------ELQQRLAELEEELEEAQEELEELEEELE 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  509 TLQSELVSKDEALEKFSLSE--------CGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKAT 580
Cdd:COG4717   231 QLENELEAAALEERLKEARLllliaaalLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQAL 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  581 SDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEvttqlnVQKADSSALDDMLRLQKEGTE-EKSTLLEKTEKELV 659
Cdd:COG4717   311 PALEELEEEELEELLAALGLPPDLSPEELLELLDRIEE------LQELLREAEELEEELQLEELEqEIAALLAEAGVEDE 384

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  660 QSKEQAAKTLNDKEQLEKQISDLK-QLAEQEKLVREMTENAI-NQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQE 737
Cdd:COG4717   385 EELRAALEQAEEYQELKEELEELEeQLEELLGELEELLEALDeEELEEELEELEEELEELEEELEELREELAELEAELEQ 464

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 442628156  738 IKAQNtqkdfELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQEL 795
Cdd:COG4717   465 LEEDG-----ELAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPPV 517
46 PHA02562
endonuclease subunit; Provisional
 1059-1297 2.22e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 49.24  E-value: 2.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1059 TIKDLQERLE-ITNAELQHKEKMASEDAQKIADLKTLVEAIQVAnanisatnaelstVLEVLQAEKSETNHIFELFEMEA 1137
Cdd:PHA02562  199 TYNKNIEEQRkKNGENIARKQNKYDELVEEAKTIKAEIEELTDE-------------LLNLVMDIEDPSAALNKLNTAAA 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1138 DMNSErlIEKVTGIKEELKETHL------QLDERQKKFEELEEKLKQAQQSEQKL---QQESQTSKEKLTEIQQSLQELQ 1208
Cdd:PHA02562  266 KIKSK--IEQFQKVIKMYEKGGVcptctqQISEGPDRITKIKDKLKELQHSLEKLdtaIDELEEIMDEFNEQSKKLLELK 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1209 DSVKQKEELVQNLEEKVRESSSIIEaqntKLNESNVqleNKTSCLKETQDQLlesqkkeKQLQEEAAKLSGELQQVQEAN 1288
Cdd:PHA02562  344 NKISTNKQSLITLVDKAKKVKAAIE----ELQAEFV---DNAEELAKLQDEL-------DKIVKTKSELVKEKYHRGIVT 409


                  ....*....
gi 442628156 1289 GDIKDSLVK 1297
Cdd:PHA02562  410 DLLKDSGIK 418
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
886-1490 2.33e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.53  E-value: 2.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  886 LLEQITKLKSEVGEtqaaLSSCHTDVESKTKQLEAAnAALEKVNKEYAESRAEASDLQD--------KVKEITDTLHAEL 957
Cdd:COG4913   223 TFEAADALVEHFDD----LERAHEALEDAREQIELL-EPIRELAERYAAARERLAELEYlraalrlwFAQRRLELLEAEL 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  958 QAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLqdsqdsqTKLKAEGERKEKSFEESIKN 1037
Cdd:COG4913   298 EELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQLEREIERL-------ERELEERERRRARLEALLAA 370

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1038 LQEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVL- 1116
Cdd:COG4913   371 LGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDALa 450

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1117 EVLQAEKSETNHIFELFEMEADMNS-----ERLI--------------EKVTGIKEELK-ETHLQLderqkkfeeleEKL 1176
Cdd:COG4913   451 EALGLDEAELPFVGELIEVRPEEERwrgaiERVLggfaltllvppehyAAALRWVNRLHlRGRLVY-----------ERV 519

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1177 KQAQQSEQKLQQESQTSKEKLT--------EIQQSLQELQDSVKqkeelVQNLEEKVRESSSI-IEAQ------------ 1235
Cdd:COG4913   520 RTGLPDPERPRLDPDSLAGKLDfkphpfraWLEAELGRRFDYVC-----VDSPEELRRHPRAItRAGQvkgngtrhekdd 594

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1236 NTKLNESNV-------QLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSG---ELQQVQEANGDIKDslvkveelVKVL 1305
Cdd:COG4913   595 RRRIRSRYVlgfdnraKLAALEAELAELEEELAEAEERLEALEAELDALQErreALQRLAEYSWDEID--------VASA 666

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1306 EEKLQAATSQLDAQQATNKELQELlvksQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDE---- 1381
Cdd:COG4913   667 EREIAELEAELERLDASSDDLAAL----EEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAaedl 742

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1382 --SNTVLESQKKSHNEIQDKLEqaQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLekGNEFDTQLAEYQKVI 1459
Cdd:COG4913   743 arLELRALLEERFAAALGDAVE--RELRENLEERIDALRARLNRAEEELERAMRAFNREWPAE--TADLDADLESLPEYL 818

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 442628156 1460 DEMDDAASV---------KSALLEQLQNRVAELETALRQA 1490
Cdd:COG4913   819 ALLDRLEEDglpeyeerfKELLNENSIEFVADLLSKLRRA 858
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1168-1515 2.45e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 49.27  E-value: 2.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1168 KFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKeelvQNLEEKVRESSSIIEAQNTKLNESNVQLE 1247
Cdd:TIGR00606  183 RYIKALETLRQVRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSK----EAQLESSREIVKSYENELDPLKNRLKEIE 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1248 NKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQV-QEANGDIKDSLVKVEELVKVLEEKLQAATSQLDA----QQAT 1322
Cdd:TIGR00606  259 HNLSKIMKLDNEIKALKSRKKQMEKDNSELELKMEKVfQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKlnkeRRLL 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1323 NKELQELLVK------------SQENEGNLQGESLAVTEKLQQLEQ---ANGELKEALCQKENGLKELQGKLDESNTVLE 1387
Cdd:TIGR00606  339 NQEKTELLVEqgrlqlqadrhqEHIRARDSLIQSLATRLELDGFERgpfSERQIKNFHTLVIERQEDEAKTAAQLCADLQ 418

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1388 SQKKSHNEIQDKLE-QAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVidEMDDAA 1466
Cdd:TIGR00606  419 SKERLKQEQADEIRdEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERELSKA--EKNSLT 496

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 442628156  1467 SVKSALLEQLQNRVAELETALRQanDAQKTAYLE-TKELRRQLESLELEK 1515
Cdd:TIGR00606  497 ETLKKEVKSLQNEKADLDRKLRK--LDQEMEQLNhHTTTRTQMEMLTKDK 544
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 665-882 2.75e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 2.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  665 AAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQ 744
Cdd:COG4942    15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  745 KDFELVESGESLKKL---QQQLEQKT-----------LGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALK 810
Cdd:COG4942    95 LRAELEAQKEELAELlraLYRLGRQPplalllspedfLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERA 174

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442628156  811 VVqvqleqlqqqaaasgEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKK 882
Cdd:COG4942   175 EL---------------EALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 347-1005 2.76e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 49.27  E-value: 2.76e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   347 MQDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVE---LESALDNERKKTEELQCSidEAQFCGDELNA 423
Cdd:TIGR00606  417 LQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKElqqLEGSSDRILELDQELRKA--ERELSKAEKNS 494

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   424 QSQVYKEKIHDLESKitklvsatpslqsilPPDLPSDDGALQEEIAKLQEKMTiQQKEVESRIAEQLEEEQRLRENVKYL 503
Cdd:TIGR00606  495 LTETLKKEVKSLQNE---------------KADLDRKLRKLDQEMEQLNHHTT-TRTQMEMLTKDKMDKDEQIRKIKSRH 558

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   504 NEQIATLQSELVSKDEaLEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSEL------QNL 577
Cdd:TIGR00606  559 SDELTSLLGYFPNKKQ-LEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLfdvcgsQDE 637

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   578 KATSDSLESERVNKTDECEILQTEVRMRDEQIREL---NQQLDEVTTQLNVQKAD----SSALDDMLRLQKEGTEEKSTL 650
Cdd:TIGR00606  638 ESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLtdeNQSCCPVCQRVFQTEAElqefISDLQSKLRLAPDKLKSTESE 717

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   651 LEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQlaEQEKLVREMTE--NAINQIQLEKESIEQQLALKQNELED----- 723
Cdd:TIGR00606  718 LKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRN--KLQKVNRDIQRlkNDIEEQETLLGTIMPEEESAKVCLTDvtime 795

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   724 -FQKKQSESEVHLQEIKAQNTQKDFELvesgeSLKKLQQQLEQKTLGHEKLQAALEELKKeketIIKEKEQELQQLQSKS 802
Cdd:TIGR00606  796 rFQMELKDVERKIAQQAAKLQGSDLDR-----TVQQVNQEKQEKQHELDTVVSKIELNRK----LIQDQQEQIQHLKSKT 866

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   803 AESESAlKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKK 882
Cdd:TIGR00606  867 NELKSE-KLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVND 945

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   883 SGHLLEQITKLKSEV------------GETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQD------ 944
Cdd:TIGR00606  946 IKEKVKNIHGYMKDIenkiqdgkddylKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDnltlrk 1025

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442628156   945 ---KVKEITDTLHAEL----QAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQE 1005
Cdd:TIGR00606 1026 renELKEVEEELKQHLkemgQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELRE 1093
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
371-570 3.14e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.14  E-value: 3.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  371 DAQNQALQLQKNINELKARIVELES---ALDNERKKTEELQCSIDE-AQFCGDELNAQSqvYKEKIHDLESKITKLVSAT 446
Cdd:COG4913   607 DNRAKLAALEAELAELEEELAEAEErleALEAELDALQERREALQRlAEYSWDEIDVAS--AEREIAELEAELERLDASS 684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  447 PSLQsilppdlpsddgALQEEIAKLQEkmtiQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSL 526
Cdd:COG4913   685 DDLA------------ALEEQLEELEA----ELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELR 748

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 442628156  527 SECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRL 570
Cdd:COG4913   749 ALLEERFAAALGDAVERELRENLEERIDALRARLNRAEEELERA 792
PRK11281 PRK11281
mechanosensitive channel MscK;
954-1491 3.44e-05

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 48.75  E-value: 3.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  954 HAELQAERSSSSALHTKLSKFSD-EIATGHKELTSKADAWSQEMLQK----EKELQELRqqlqdsqdsqtKLKAEGERKE 1028
Cdd:PRK11281   28 RAASNGDLPTEADVQAQLDALNKqKLLEAEDKLVQQDLEQTLALLDKidrqKEETEQLK-----------QQLAQAPAKL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1029 KSFEESIKNLQEEVTKAKTENLElstgtQTTIKDLQERLEITNAELQhkekmaseDAQkiadlktlvEAIQVANANISAt 1108
Cdd:PRK11281   97 RQAQAELEALKDDNDEETRETLS-----TLSLRQLESRLAQTLDQLQ--------NAQ---------NDLAEYNSQLVS- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1109 naeLSTVLEVLQAEKSEtnhifelfemeadmNSERLiekvtgikeelkethlqlderqkkfEELEEKLKQAQQSEQKLQQ 1188
Cdd:PRK11281  154 ---LQTQPERAQAALYA--------------NSQRL-------------------------QQIRNLLKGGKVGGKALRP 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1189 ESQTskekLTEIQQSLQELQDSVKQKE----ELVQNLEEKVREsssiieaqntKLNESNVQLEnktsclKETQD-QLLES 1263
Cdd:PRK11281  192 SQRV----LLQAEQALLNAQNDLQRKSlegnTQLQDLLQKQRD----------YLTARIQRLE------HQLQLlQEAIN 251

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1264 QKKEKQLQEEAAklsgELQQVQEANGDIKDSLVKveelvkvleeklqaatsqldAQQATNKELQELLVKSqenegnlqge 1343
Cdd:PRK11281  252 SKRLTLSEKTVQ----EAQSQDEAARIQANPLVA--------------------QELEINLQLSQRLLKA---------- 297

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1344 slavTEKLQQLEQANGELK---EALCQKENGLKE----LQGKLdesntVLesqkkshNEIqdkLEQAQQKERTLQeETSK 1416
Cdd:PRK11281  298 ----TEKLNTLTQQNLRVKnwlDRLTQSERNIKEqisvLKGSL-----LL-------SRI---LYQQQQALPSAD-LIEG 357

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442628156 1417 LAEQLSQLKQAneelQKSLQQKQLLLEKGNEFDTQLAEYQKVidEMDDAasVKSALLEQLQNRVAELETALRQAN 1491
Cdd:PRK11281  358 LADRIADLRLE----QFEINQQRDALFQPDAYIDKLEAGHKS--EVTDE--VRDALLQLLDERRELLDQLNKQLN 424
PLN02939 PLN02939
transferase, transferring glycosyl groups
 1044-1400 3.70e-05

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 48.74  E-value: 3.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1044 KAKTENLELSTGTQTTIKDLQERLEiTNAELQHKEKMASEDAQKIADlkTLVEAIQVANANISATNAELSTVLEVLQAEK 1123
Cdd:PLN02939   36 RARRRGFSSQQKKKRGKNIAPKQRS-SNSKLQSNTDENGQLENTSLR--TVMELPQKSTSSDDDHNRASMQRDEAIAAID 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1124 SETNHIFELFEMEADMNSERLIEKvtgIKEELKETHLQLDERQKKFEELEEKLKQaqqsEQKLQQESQTSKEKLTEIQQS 1203
Cdd:PLN02939  113 NEQQTNSKDGEQLSDFQLEDLVGM---IQNAEKNILLLNQARLQALEDLEKILTE----KEALQGKINILEMRLSETDAR 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1204 LQeLQDSVKQKEELVQNLEEKVRESSSIIEAQN-----------TKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQE 1272
Cdd:PLN02939  186 IK-LAAQEKIHVEILEEQLEKLRNELLIRGATEglcvhslskelDVLKEENMLLKDDIQFLKAELIEVAETEERVFKLEK 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1273 EAAKLSGELQQVQ----EANGDI-KDSLVKVE---ELVKVLEEKLQAATSQLDAQQAT---NKELQELLVKSQEN--EGN 1339
Cdd:PLN02939  265 ERSLLDASLRELEskfiVAQEDVsKLSPLQYDcwwEKVENLQDLLDRATNQVEKAALVldqNQDLRDKVDKLEASlkEAN 344

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442628156 1340 LQGESLAVTEKLQQ--------LEQANGELKEALCQKENGLKELQGKLdeSNTVLESQKKSHNEIQDKL 1400
Cdd:PLN02939  345 VSKFSSYKVELLQQklklleerLQASDHEIHSYIQLYQESIKEFQDTL--SKLKEESKKRSLEHPADDM 411
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1142-1281 5.43e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.46  E-value: 5.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1142 ERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQ---ESQTSKEkLTEIQQSLQELQDSVKQKEELV 1218
Cdd:COG1579    34 AELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEqlgNVRNNKE-YEALQKEIESLKRRISDLEDEI 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442628156 1219 QNLEEKVRESSSIIEAQNTKLNESNVQLENKTsclKETQDQLLESQKKEKQLQEEAAKLSGEL 1281
Cdd:COG1579   113 LELMERIEELEEELAELEAELAELEAELEEKK---AELDEELAELEAELEELEAEREELAAKI 172
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 772-939 5.95e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.46  E-value: 5.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  772 KLQAALEELKKEKETI---IKEKEQELQQLQSKSAESESALKVVQvqleqlqqqaaasgeegsKTVAKLHDEISQLKSQA 848
Cdd:COG1579    14 ELDSELDRLEHRLKELpaeLAELEDELAALEARLEAAKTELEDLE------------------KEIKRLELEIEEVEARI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  849 EETQSELKSTQSN--LEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALE 926
Cdd:COG1579    76 KKYEEQLGNVRNNkeYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELE 155

                         170
                  ....*....|...
gi 442628156  927 KVNKEYAESRAEA 939
Cdd:COG1579   156 AELEELEAEREEL 168
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1073-1520 6.17e-05

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 47.89  E-value: 6.17e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1073 ELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEK--SETNHIFELFEMEADMN-SERLIEKVT 1149
Cdd:pfam10174  213 EELHRRNQLQPDPAKTKALQTVIEMKDTKISSLERNIRDLEDEVQMLKTNGllHTEDREEEIKQMEVYKShSKFMKNKID 292

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1150 GIKEEL--KETHL------------QLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKE 1215
Cdd:pfam10174  293 QLKQELskKESELlalqtkletltnQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLT 372

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1216 ELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDI---- 1291
Cdd:pfam10174  373 EEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLEEALSEKerii 452

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1292 --------KDSLVKVEELvKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKE 1363
Cdd:pfam10174  453 erlkeqreREDRERLEEL-ESLKKENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKE 531

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1364 ALCQKENGLKELQGkldesntvLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQlllE 1443
Cdd:pfam10174  532 ECSKLENQLKKAHN--------AEEAVRTNPEINDRIRLLEQEVARYKEESGKAQAEVERLLGILREVENEKNDKD---K 600

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442628156  1444 KGNEFDTQLAEYQKviDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAyletkeLRRQLESL--ELEKSREVL 1520
Cdd:pfam10174  601 KIAELESLTLRQMK--EQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNS------QQLQLEELmgALEKTRQEL 671
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 351-523 7.09e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.07  E-value: 7.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  351 LREKQQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQfcgDELNAQSQVYKE 430
Cdd:COG4942    32 LQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR---AELEAQKEELAE 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  431 KIHDLEskitkLVSATPSLQSILPPDLPSDDG---------------------ALQEEIAKLQEKMTIQQKEVESRIAEQ 489
Cdd:COG4942   109 LLRALY-----RLGRQPPLALLLSPEDFLDAVrrlqylkylaparreqaeelrADLAELAALRAELEAERAELEALLAEL 183

                         170       180       190
                  ....*....|....*....|....*....|....
gi 442628156  490 LEEEQRLRENVKYLNEQIATLQSELVSKDEALEK 523
Cdd:COG4942   184 EEERAALEALKAERQKLLARLEKELAELAAELAE 217
PRK11281 PRK11281
mechanosensitive channel MscK;
647-894 7.86e-05

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 47.60  E-value: 7.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  647 KSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQ-LAEQEKLVREMTEN---------AINQIQLEKESI---EQQ 713
Cdd:PRK11281   50 KQKLLEAEDKLVQQDLEQTLALLDKIDRQKEETEQLKQqLAQAPAKLRQAQAElealkddndEETRETLSTLSLrqlESR 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  714 LALKQNELEDFQKK-----------QSESE----------VHLQEIKAQ-NTQKDFELVESGESLKKLQQQL-------- 763
Cdd:PRK11281  130 LAQTLDQLQNAQNDlaeynsqlvslQTQPEraqaalyansQRLQQIRNLlKGGKVGGKALRPSQRVLLQAEQallnaqnd 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  764 -EQKTL-GHEKLQAALEELKKEKETIIKEKEQELQQLQskSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAK---LH 838
Cdd:PRK11281  210 lQRKSLeGNTQLQDLLQKQRDYLTARIQRLEHQLQLLQ--EAINSKRLTLSEKTVQEAQSQDEAARIQANPLVAQeleIN 287

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 442628156  839 DEISQLKSQAEETQSELksTQSNLEAKSkQLEAANGSleEEAKKsghllEQITKLK 894
Cdd:PRK11281  288 LQLSQRLLKATEKLNTL--TQQNLRVKN-WLDRLTQS--ERNIK-----EQISVLK 333
CLIP1_ZNF pfam16641
CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of ...
 1599-1616 9.42e-05

CLIP1 zinc knuckle; This zinc knuckle domain is found tandemly repeated at the C-terminal of the cytoplasmic linker protein CLIP1 (CLIP170). It forms a complex with the CAP-Gly domain of Dynactin.


Pssm-ID: 465212  Cd Length: 17  Bit Score: 40.91  E-value: 9.42e-05
                           10
                   ....*....|....*...
gi 442628156  1599 RLFCDICDEFDqHDTEDC 1616
Cdd:pfam16641    1 RPYCEICEVFG-HDTEDC 17
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1204-1428 9.49e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.75  E-value: 9.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1204 LQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQ 1283
Cdd:COG3883    18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYR 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1284 vQEANGDIKDSLVKVEEL------VKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQA 1357
Cdd:COG3883    98 -SGGSVSYLDVLLGSESFsdfldrLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQ 176

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442628156 1358 NGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQAN 1428
Cdd:COG3883   177 QAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAA 247
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1346-1551 1.03e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.07  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1346 AVTEKLQQLEQANGELKEALCQKengLKELQGKLDEsntvLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLK 1425
Cdd:COG4717    50 RLEKEADELFKPQGRKPELNLKE---LKELEEELKE----AEEKEEEYAELQEELEELEEELEELEAELEELREELEKLE 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1426 QANE------ELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYL 1499
Cdd:COG4717   123 KLLQllplyqELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELE 202

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 442628156 1500 ETKELRRQLESLELEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKI 1551
Cdd:COG4717   203 ELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLI 254
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1056-1463 1.05e-04

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 46.75  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1056 TQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQvanANISATNAELSTVLEVLQAEKSETNHIFELFE- 1134
Cdd:PRK04778  110 IESLLDLIEEDIEQILEELQELLESEEKNREEVEQLKDLYRELR---KSLLANRFSFGPALDELEKQLENLEEEFSQFVe 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1135 -------MEADMNSERLIEKVTGIKEELKETHLQLDERQKKF----EELEEKLKQAQQS-----EQKLQQESQTSKEKLT 1198
Cdd:PRK04778  187 ltesgdyVEAREILDQLEEELAALEQIMEEIPELLKELQTELpdqlQELKAGYRELVEEgyhldHLDIEKEIQDLKEQID 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1199 EIQQSLQELQdsVKQKEELVQNLEEKVRESSSIIEaqnTKLNESNVQLENKtsclKETQDQLLESQKKEKQLQEEAAKLS 1278
Cdd:PRK04778  267 ENLALLEELD--LDEAEEKNEEIQERIDQLYDILE---REVKARKYVEKNS----DTLPDFLEHAKEQNKELKEEIDRVK 337

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1279 -------GELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATS---QLDAQQATNKELQELLVKSQENEGNLQGESLAVT 1348
Cdd:PRK04778  338 qsytlneSELESVRQLEKQLESLEKQYDEITERIAEQEIAYSElqeELEEILKQLEEIEKEQEKLSEMLQGLRKDELEAR 417

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1349 EKLQQLEQANGELKEALcQKEN--GL--------KELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSK-- 1416
Cdd:PRK04778  418 EKLERYRNKLHEIKRYL-EKSNlpGLpedylemfFEVSDEIEALAEELEEKPINMEAVNRLLEEATEDVETLEEETEElv 496

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 442628156 1417 ----LAEQLSQ----LKQANEELQKSLQQKQLLLeKGNEFDTQLAEYQKVIDEMD 1463
Cdd:PRK04778  497 enatLTEQLIQyanrYRSDNEEVAEALNEAERLF-REYDYKAALEIIATALEKVE 550
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1192-1509 1.22e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 46.84  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1192 TSKEKLTEIQQSLQELQdsvkqkeeLVQnLEEKVRESSSiieAQNTKLNESNVQLENKTSCLKetqdQLLESQKKEKQLQ 1271
Cdd:PRK05771   13 TLKSYKDEVLEALHELG--------VVH-IEDLKEELSN---ERLRKLRSLLTKLSEALDKLR----SYLPKLNPLREEK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1272 EEAAKLSGElqqvqEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQ-----ELLVKSQENEGNLQGESLA 1346
Cdd:PRK05771   77 KKVSVKSLE-----ELIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERLEpwgnfDLDLSLLLGFKYVSVFVGT 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1347 VTEKLQQLEQANGELKEALCQKENGLKE------LQGKLDESNTVLESQKKSHNEIQDkleqaqqkERTLQEETSKLAEQ 1420
Cdd:PRK05771  152 VPEDKLEELKLESDVENVEYISTDKGYVyvvvvvLKELSDEVEEELKKLGFERLELEE--------EGTPSELIREIKEE 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1421 LSQLKQANEELQKSLqqkqlllekgNEFDTQLAEYQKVIDEMDDAASVKSALLEQL--------------QNRVAELETA 1486
Cdd:PRK05771  224 LEEIEKERESLLEEL----------KELAKKYLEELLALYEYLEIELERAEALSKFlktdktfaiegwvpEDRVKKLKEL 293

                         330       340
                  ....*....|....*....|...
gi 442628156 1487 LRQANDaqKTAYLETKELRRQLE 1509
Cdd:PRK05771  294 IDKATG--GSAYVEFVEPDEEEE 314
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 708-1290 1.24e-04

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 47.05  E-value: 1.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   708 ESIEQQLALKQNELEDFQKKQSEsevhLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETI 787
Cdd:pfam07111   59 QALSQQAELISRQLQELRRLEEE----VRLLRETSLQQKMRLEAQAMELDALAVAEKAGQAEAEGLRAALAGAEMVRKNL 134

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   788 IKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTV----AKLHDEISQLKSQAEETQSELKSTQSNLE 863
Cdd:pfam07111  135 EEGSQRELEEIQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLNSLetkrAGEAKQLAEAQKEAELLRKQLSKTQEELE 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   864 AKSKQLEAANGSLEEEAKKSGH----------LLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEK------ 927
Cdd:pfam07111  215 AQVTLVESLRKYVGEQVPPEVHsqtwelerqeLLDTMQHLQEDRADLQATVELLQVRVQSLTHMLALQEEELTRkiqpsd 294

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   928 -VNKEYAES-RAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSkfsdeiatghkELTSKADAWSQEMLQKEKELQE 1005
Cdd:pfam07111  295 sLEPEFPKKcRSLLNRWREKVFALMVQLKAQDLEHRDSVKQLRGQVA-----------ELQEQVTSQSQEQAILQRALQD 363

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1006 LRQQLQDSQDSQTKLKAEGERKEKSfeesiKNLQEEVTKAKTENLELSTG----TQTTIKDLQERLEITNAELQHKEKMA 1081
Cdd:pfam07111  364 KAAEVEVERMSAKGLQMELSRAQEA-----RRRQQQQTASAEEQLKFVVNamssTQIWLETTMTRVEQAVARIPSLSNRL 438

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1082 SEDAQKIADLKTLVeAIQVANANISA-----------TNAELSTVLEVLQAEKSETNHIFELfemeadmnSERLIEKVTG 1150
Cdd:pfam07111  439 SYAVRKVHTIKGLM-ARKVALAQLRQescpppppappVDADLSLELEQLREERNRLDAELQL--------SAHLIQQEVG 509

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1151 IKEELKEThlqlderqkkfeELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDS-----------VKQKEELVQ 1219
Cdd:pfam07111  510 RAREQGEA------------ERQQLSEVAQQLEQELQRAQESLASVGQQLEVARQGQQESteeaaslrqelTQQQEIYGQ 577

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1220 NLEEKVRESSSIIEAQ--NTKLNESNVQLENKTSCLKETQDQLLESQKKE-----KQLQEEAAKLSGE--LQQVQEANGD 1290
Cdd:pfam07111  578 ALQEKVAEVETRLREQlsDTKRRLNEARREQAKAVVSLRQIQHRATQEKErnqelRRLQDEARKEEGQrlARRVQELERD 657
PRK01156 PRK01156
chromosome segregation protein; Provisional
 759-1363 1.41e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.82  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  759 LQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESAlkvvqvqleqlqqqaaasgEEGSKTVAKLH 838
Cdd:PRK01156  188 LEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNL-------------------KSALNELSSLE 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  839 DEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQL 918
Cdd:PRK01156  249 DMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAII 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  919 EAAnAALEKVNKEYAESRAEASDLQDKVKEItDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQ 998
Cdd:PRK01156  329 KKL-SVLQKDYNDYIKKKSRYDDLNNQILEL-EGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDA 406

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  999 KEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTT---IKDLQERLEITNAELQ 1075
Cdd:PRK01156  407 IKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQSVCPVCGTTLGEEKSnhiINHYNEKKSRLEEKIR 486

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1076 HKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVlqaeksetnhifelfEMEADMNSErliekvtgikEEL 1155
Cdd:PRK01156  487 EIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARA---------------DLEDIKIKI----------NEL 541

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1156 KETHLQLDERQKKFEELE-EKLKQaqQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEA 1234
Cdd:PRK01156  542 KDKHDKYEEIKNRYKSLKlEDLDS--KRTSWLNALAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDK 619

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1235 QNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSlvkvEELVKVLEEKLQAATS 1314
Cdd:PRK01156  620 SIREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDI----EDNLKKSRKALDDAKA 695

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|...
gi 442628156 1315 QLDAQQATNKEL----QELLVKSQENEGNLqgeslavtEKLQQLEQANGELKE 1363
Cdd:PRK01156  696 NRARLESTIEILrtriNELSDRINDINETL--------ESMKKIKKAIGDLKR 740
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 899-1636 1.42e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 46.97  E-value: 1.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   899 ETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITD------TLHAELQAERSSSSALHTKLS 972
Cdd:TIGR01612  541 EIEAGLKESYELAKNWKKLIHEIKKELEEENEDSIHLEKEIKDLFDKYLEIDDeiiyinKLKLELKEKIKNISDKNEYIK 620

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   973 KfsdeiATGHKELTSKADAWSQEmLQKEKELQELRQQLQDSQDSQTkLKAEgerKEKSFEESIKNLQEEVTKAKTENLEL 1052
Cdd:TIGR01612  621 K-----AIDLKKIIENNNAYIDE-LAKISPYQVPEHLKNKDKIYST-IKSE---LSKIYEDDIDALYNELSSIVKENAID 690

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1053 STGTQTTIKDLQERLEITNAELQHKEKMASE------DAQKIADLKTLVEAIQVANANIsatNAELSTVLEVLQA-EKSE 1125
Cdd:TIGR01612  691 NTEDKAKLDDLKSKIDKEYDKIQNMETATVElhlsniENKKNELLDIIVEIKKHIHGEI---NKDLNKILEDFKNkEKEL 767

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1126 TNHIFELFEMEADMNSERliEKVTGIK--------------EELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQE-- 1189
Cdd:TIGR01612  768 SNKINDYAKEKDELNKYK--SKISEIKnhyndqinidnikdEDAKQNYDKSKEYIKTISIKEDEIFKIINEMKFMKDDfl 845

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1190 ---------SQTSKEKLTEIQQSLQELQDSVKQK--EELVQNLEEKVRESSSIIEAQNTKLNE--SNVQLENKTS----C 1252
Cdd:TIGR01612  846 nkvdkfinfENNCKEKIDSEHEQFAELTNKIKAEisDDKLNDYEKKFNDSKSLINEINKSIEEeyQNINTLKKVDeyikI 925

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1253 LKETQDQLLESQKKEKQLQEeaaKLSGELQQVQEAN-------GDIKDSLV-KVEELVKVLEEklqaatSQLDAQQATNK 1324
Cdd:TIGR01612  926 CENTKESIEKFHNKQNILKE---ILNKNIDTIKESNlieksykDKFDNTLIdKINELDKAFKD------ASLNDYEAKNN 996

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1325 ELQELLVKSQENEGNLQGESL---------AVTEKLQQLEQANGELKE-------ALCQKENGLKELQGKLDES--NTVL 1386
Cdd:TIGR01612  997 ELIKYFNDLKANLGKNKENMLyhqfdekekATNDIEQKIEDANKNIPNieiaihtSIYNIIDEIEKEIGKNIELlnKEIL 1076

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1387 ESQKKS---HNEIQDKLEQAQQKErTLQEETSKLAEQLSQLKQ----ANEELQKSLQQKQLLLEKG----NEFDTQLAEY 1455
Cdd:TIGR01612 1077 EEAEINitnFNEIKEKLKHYNFDD-FGKEENIKYADEINKIKDdiknLDQKIDHHIKALEEIKKKSenyiDEIKAQINDL 1155

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1456 QKVIDEMDDAASVKSaLLEQLQNRVAELetalrqanDAQKTAYLETKELRRQLESLELEKSrevlSLKaQMNGASSRSGK 1535
Cdd:TIGR01612 1156 EDVADKAISNDDPEE-IEKKIENIVTKI--------DKKKNIYDEIKKLLNEIAEIEKDKT----SLE-EVKGINLSYGK 1221

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1536 gdevesldietSLAKInFLNSIIADMQQKNDALKAKVQTLETLpmdftkphafDALTKRKPAPRLFCDICDEFDQhDTED 1615
Cdd:TIGR01612 1222 -----------NLGKL-FLEKIDEEKKKSEHMIKAMEAYIEDL----------DEIKEKSPEIENEMGIEMDIKA-EMET 1278

                          810       820
                   ....*....|....*....|.
gi 442628156  1616 CPIQGSEDQDYSTPSSESNNN 1636
Cdd:TIGR01612 1279 FNISHDDDKDHHIISKKHDEN 1299
PRK01156 PRK01156
chromosome segregation protein; Provisional
 558-1236 1.44e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.82  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  558 RKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDeceiLQTEVRMRDEQIRELNQQLDEvttqlnvqkaDSSALDDML 637
Cdd:PRK01156  152 KKILDEILEINSLERNYDKLKDVIDMLRAEISNIDY----LEEKLKSSNLELENIKKQIAD----------DEKSHSITL 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  638 RLQKEGTEEkstlLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQlAEQEKLVREMTENAINQIQLEKESIEQQLAL- 716
Cdd:PRK01156  218 KEIERLSIE----YNNAMDDYNNLKSALNELSSLEDMKNRYESEIKT-AESDLSMELEKNNYYKELEERHMKIINDPVYk 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  717 KQNELEDFQKKQSESEVHLQEIKaqntQKDFELVESGESLKKLQQQleqktlghEKLQAALEELKKEKETIikekEQELQ 796
Cdd:PRK01156  293 NRNYINDYFKYKNDIENKKQILS----NIDAEINKYHAIIKKLSVL--------QKDYNDYIKKKSRYDDL----NNQIL 356

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  797 QLQSKSAESESALKVVQVQLEQLqqqaaasgEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSL 876
Cdd:PRK01156  357 ELEGYEMDYNSYLKSIESLKKKI--------EEYSKNIERMSAFISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSL 428

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  877 EEEAKKSGHLLEQITKlKSEVGETQAALSSCHTDV-ESKTKQL-EAANAALEKVNKEYAESRAEASDLQDKVKEitdtlh 954
Cdd:PRK01156  429 NQRIRALRENLDELSR-NMEMLNGQSVCPVCGTTLgEEKSNHIiNHYNEKKSRLEEKIREIEIEVKDIDEKIVD------ 501

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  955 aelqaerssssalhtkLSKFSDEIATGHKEltskadawsqEMLQKEKELQELRQQLQDSQDSQTKLKaEGERKEKSFEES 1034
Cdd:PRK01156  502 ----------------LKKRKEYLESEEIN----------KSINEYNKIESARADLEDIKIKINELK-DKHDKYEEIKNR 554

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1035 IKNLQEEVTKAKTE--NLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEaiqvananisatnael 1112
Cdd:PRK01156  555 YKSLKLEDLDSKRTswLNALAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYID---------------- 618

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1113 STVLEVLQAEKSETNHIFELFEMEadmnseRLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQT 1192
Cdd:PRK01156  619 KSIREIENEANNLNNKYNEIQENK------ILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDD 692

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 442628156 1193 SKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQN 1236
Cdd:PRK01156  693 AKANRARLESTIEILRTRINELSDRINDINETLESMKKIKKAIG 736
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
483-727 1.48e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.83  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  483 ESRIAEQLEEEQRLRENVKYLNEQIATLQSELvskdEALEKFSLSECGIENLRRELELLKeenekQAQEAQAEFTRKLAE 562
Cdd:COG4913   609 RAKLAALEAELAELEEELAEAEERLEALEAEL----DALQERREALQRLAEYSWDEIDVA-----SAEREIAELEAELER 679

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  563 ksveVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNvqkadssalddmlRLQKE 642
Cdd:COG4913   680 ----LDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLE-------------AAEDL 742

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  643 GTEEKSTLLEKTEKELVQSKEQAAKtlndKEQLEKQISDLKQLAEQ--EKLVREMTE------NAINQIQLEKESIEQQL 714
Cdd:COG4913   743 ARLELRALLEERFAAALGDAVEREL----RENLEERIDALRARLNRaeEELERAMRAfnrewpAETADLDADLESLPEYL 818

                         250
                  ....*....|....*..
gi 442628156  715 A----LKQNELEDFQKK 727
Cdd:COG4913   819 AlldrLEEDGLPEYEER 835
mukB PRK04863
chromosome partition protein MukB;
831-1497 1.52e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 46.87  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  831 SKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAkskqLEAANGSLEEEAKK-SGHLLEQITKLKSevgetQAALSSCHT 909
Cdd:PRK04863  285 LEEALELRRELYTSRRQLAAEQYRLVEMARELAE----LNEAESDLEQDYQAaSDHLNLVQTALRQ-----QEKIERYQA 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  910 DVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTL-----------------HAELQAERSSSSALHtkLS 972
Cdd:PRK04863  356 DLEELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQLadyqqaldvqqtraiqyQQAVQALERAKQLCG--LP 433

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  973 KFSDEIATG-HKELTSKADAWSQEMLQKEKEL---QELRQQLQDSQDSQTKLKAEGERKE--KSFEESIKNLQEEvtKAK 1046
Cdd:PRK04863  434 DLTADNAEDwLEEFQAKEQEATEELLSLEQKLsvaQAAHSQFEQAYQLVRKIAGEVSRSEawDVARELLRRLREQ--RHL 511

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1047 TENLElstGTQTTIKDLQERLEitnaelQHKekmaseDAQKIADlktlvEAIQVANANIsaTNAELstvLEVLQAEKSET 1126
Cdd:PRK04863  512 AEQLQ---QLRMRLSELEQRLR------QQQ------RAERLLA-----EFCKRLGKNL--DDEDE---LEQLQEELEAR 566

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1127 nhifelfemeadmnserliekvtgiKEELKETHLQLDERQkkfEELEEKLKQAQQSEQKLQQES---QTSKEKLTEIQQS 1203
Cdd:PRK04863  567 -------------------------LESLSESVSEARERR---MALRQQLEQLQARIQRLAARApawLAAQDALARLREQ 618

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1204 LQELQDSVKQKEELVQNLEEKVREsssiieaqntkLNESNVQLENKTSCLKETQDQLLESQKKE-KQLQEEAAKLSGELQ 1282
Cdd:PRK04863  619 SGEEFEDSQDVTEYMQQLLERERE-----------LTVERDELAARKQALDEEIERLSQPGGSEdPRLNALAERFGGVLL 687

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1283 -------QVQEA---------------------------------------NGDI---KDSLVKVEEL-----VKVLEEK 1308
Cdd:PRK04863  688 seiyddvSLEDApyfsalygparhaivvpdlsdaaeqlagledcpedlyliEGDPdsfDDSVFSVEELekavvVKIADRQ 767

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1309 LQ-------------AATSQLDAQQATNKELQELLVKSQENEGNLQ----------GESLAV------------------ 1347
Cdd:PRK04863  768 WRysrfpevplfgraAREKRIEQLRAEREELAERYATLSFDVQKLQrlhqafsrfiGSHLAVafeadpeaelrqlnrrrv 847

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1348 --TEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVL-ESQKKSHNEIQDKLEQAQQKERTLQEETSKLA------ 1418
Cdd:PRK04863  848 elERALADHESQEQQQRSQLEQAKEGLSALNRLLPRLNLLAdETLADRVEEIREQLDEAEEAKRFVQQHGNALAqlepiv 927

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1419 -------EQLSQLKQA---NEELQKSLQQKQLLLEKGNEFDTQLAeYQKVIDEMDDAasvkSALLEQLQNRVAELETALR 1488
Cdd:PRK04863  928 svlqsdpEQFEQLKQDyqqAQQTQRDAKQQAFALTEVVQRRAHFS-YEDAAEMLAKN----SDLNEKLRQRLEQAEQERT 1002


                  ....*....
gi 442628156 1489 QANDAQKTA 1497
Cdd:PRK04863 1003 RAREQLRQA 1011
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 673-950 1.69e-04

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 46.58  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  673 EQLEKQisdLKQLAEQEKLVREMTENAINQIQLEKESIEQQLalKQNELEDF----QKKQSESEVHLQEIKAQNTQKDFE 748
Cdd:PTZ00108 1002 GKLERE---LARLSNKVRFIKHVINGELVITNAKKKDLVKEL--KKLGYVRFkdiiKKKSEKITAEEEEGAEEDDEADDE 1076

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  749 LVESG--------------------ESLKKLQQQLEQKTLGHEKLQAA------LEELKKEKETIIKEKEQE----LQQL 798
Cdd:PTZ00108 1077 DDEEElgaavsydyllsmpiwsltkEKVEKLNAELEKKEKELEKLKNTtpkdmwLEDLDKFEEALEEQEEVEekeiAKEQ 1156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  799 QSKSAESESALKVVQ-VQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLE 877
Cdd:PTZ00108 1157 RLKSKTKGKASKLRKpKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPK 1236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442628156  878 EEAKKSGHLLEQITKLKSEVGETQaalSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEIT 950
Cdd:PTZ00108 1237 KSSVKRLKSKKNNSSKSSEDNDEF---SSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSPT 1306
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
660-863 1.80e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.16  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  660 QSKEQAAKTLndkEQLEKQISDLK-QLAEQEKLVRE-MTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQE 737
Cdd:COG3206   168 LRREEARKAL---EFLEEQLPELRkELEEAEAALEEfRQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAA 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  738 IKAQNTQKDFELVESGES---------LKKLQQQLEQKTL----GHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAE 804
Cdd:COG3206   245 LRAQLGSGPDALPELLQSpviqqlraqLAELEAELAELSArytpNHPDVIALRAQIAALRAQLQQEAQRILASLEAELEA 324

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 442628156  805 SESALKVVQVQLEQLQQQaaasgeegSKTVAKLHDEISQLKSQAEETQSELKSTQSNLE 863
Cdd:COG3206   325 LQAREASLQAQLAQLEAR--------LAELPELEAELRRLEREVEVARELYESLLQRLE 375
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 836-1530 1.89e-04

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 46.33  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  836 KLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAkksgHLLEQITKLKSEVGETQAALSSCHTDVESKT 915
Cdd:PRK10246  202 KLQAQASGVALLTPEQVQSLTASLQVLTDEEKQLLTAQQQQQQSL----NWLTRLDELQQEASRRQQALQQALAAEEKAQ 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  916 KQLEAAN-------------------AALEKVNKEYAESRA---EASDLQDKVKEITDTLHAELQAERSSSS---ALHTK 970
Cdd:PRK10246  278 PQLAALSlaqparqlrphweriqeqsAALAHTRQQIEEVNTrlqSTMALRARIRHHAAKQSAELQAQQQSLNtwlAEHDR 357

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  971 LSKFSDEIATGHKELT------SKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTK 1044
Cdd:PRK10246  358 FRQWNNELAGWRAQFSqqtsdrEQLRQWQQQLTHAEQKLNALPAITLTLTADEVAAALAQHAEQRPLRQRLVALHGQIVP 437

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1045 AKTENLELstgtQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAiqvananiSATNAELSTVLEVLQAEK- 1123
Cdd:PRK10246  438 QQKRLAQL----QVAIQNVTQEQTQRNAALNEMRQRYKEKTQQLADVKTICEQ--------EARIKDLEAQRAQLQAGQp 505

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1124 ----SETNH--IFELFEMEADMNSERL--IEK-VTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSK 1194
Cdd:PRK10246  506 cplcGSTSHpaVEAYQALEPGVNQSRLdaLEKeVKKLGEEGAALRGQLDALTKQLQRDESEAQSLRQEEQALTQQWQAVC 585

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1195 EKLTEIQQSLQELQDSVKQKEELVQNLEE--KVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQL---LESQKKEKQ 1269
Cdd:PRK10246  586 ASLNITLQPQDDIQPWLDAQEEHERQLRLlsQRHELQGQIAAHNQQIIQYQQQIEQRQQQLLTALAGYaltLPQEDEEAS 665

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1270 LQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQgeslavte 1349
Cdd:PRK10246  666 WLATRQQEAQSWQQRQNELTALQNRIQQLTPLLETLPQSDDLPHSEETVALDNWRQVHEQCLSLHSQLQTLQ-------- 737

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1350 klQQLEQANGELKEALCQKENGLKelqgkldesNTVLESqkkshneiqdkleQAQQKERTLQEETsklAEQLSQLKQAne 1429
Cdd:PRK10246  738 --QQDVLEAQRLQKAQAQFDTALQ---------ASVFDD-------------QQAFLAALLDEET---LTQLEQLKQN-- 788

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1430 eLQKSLQQKQLLLEKGNEfdtQLAEYQKVIDE-MDDAASVksallEQLQNRVAELETALRQANDAQktayletKELRRQL 1508
Cdd:PRK10246  789 -LENQRQQAQTLVTQTAQ---ALAQHQQHRPDgLDLTVTV-----EQIQQELAQLAQQLRENTTRQ-------GEIRQQL 852

                         730       740
                  ....*....|....*....|..
gi 442628156 1509 ESlELEKSREVLSLKAQMNGAS 1530
Cdd:PRK10246  853 KQ-DADNRQQQQALMQQIAQAT 873
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 735-966 1.92e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.59  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  735 LQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEketiIKEKEQELQQLQSKSAESESALKVVQV 814
Cdd:COG3883    18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAE----IDKLQAEIAEAEAEIEERREELGERAR 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  815 QLEQLQQQAAASGE-EGSKTVAKLHDEISQLKSQAEETQS---ELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQI 890
Cdd:COG3883    94 ALYRSGGSVSYLDVlLGSESFSDFLDRLSALSKIADADADlleELKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442628156  891 TKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSA 966
Cdd:COG3883   174 EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAGA 249
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 725-966 2.12e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.53  E-value: 2.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  725 QKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQktlgHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAE 804
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAA----LERRIAALARRIRALEQELAALEAELAELEKEIAE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  805 SESALKVVQVQLEQLQQQAAASGEegsktvaklHDEISQLKSQAEETQSE--LKSTQSNLEAKSKQLEAANGSLEEEAKK 882
Cdd:COG4942    95 LRAELEAQKEELAELLRALYRLGR---------QPPLALLLSPEDFLDAVrrLQYLKYLAPARREQAEELRADLAELAAL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  883 SGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERS 962
Cdd:COG4942   166 RAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245


                  ....
gi 442628156  963 SSSA 966
Cdd:COG4942   246 AGFA 249
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 337-730 2.26e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 45.66  E-value: 2.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   337 ILATPKSQFsMQDLLREKQQHVEKLMVE-------RDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQC 409
Cdd:pfam07888   23 LLVVPRAEL-LQNRLEECLQERAELLQAqeaanrqREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEE 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   410 SIDEAQFCGDELNAQSQVYKEKIHDLESKITKlvsatpslqsilppdlpsddgaLQEEIAKLQEKMTIQQKEVEsRIAEQ 489
Cdd:pfam07888  102 KYKELSASSEELSEEKDALLAQRAAHEARIRE----------------------LEEDIKTLTQRVLERETELE-RMKER 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   490 LEEEQRLRENVKYLNEQiatLQSELVSKDEALEKFSLSECGIENlrreLELLKEENEKQAQEAQAEFTRKLAEKSVEVLR 569
Cdd:pfam07888  159 AKKAGAQRKEEEAERKQ---LQAKLQQTEEELRSLSKEFQELRN----SLAQRDTQVLQLQDTITTLTQKLTTAHRKEAE 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   570 LSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVtTQLNVQKADSSAldDMLRLQKEGTEEKST 649
Cdd:pfam07888  232 NEALLEELRSLQERLNASERKVEGLGEELSSMAAQRDRTQAELHQARLQA-AQLTLQLADASL--ALREGRARWAQERET 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   650 LLEKTEKELVQSKEQAAKTLNDKEQLEKQISDlKQLAEQEkLVREMTENAINQIQLEKESIEQQLALK--QNELEDFQKK 727
Cdd:pfam07888  309 LQQSAEADKDRIEKLSAELQRLEERLQEERME-REKLEVE-LGREKDCNRVQLSESRRELQELKASLRvaQKEKEQLQAE 386


                   ...
gi 442628156   728 QSE 730
Cdd:pfam07888  387 KQE 389
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 1177-1433 2.70e-04

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 45.19  E-value: 2.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1177 KQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEA---QNTKLNESNVQLENKTSCL 1253
Cdd:pfam15905   55 KVKSLELKKKSQKNLKESKDQKELEKEIRALVQERGEQDKRLQALEEELEKVEAKLNAavrEKTSLSASVASLEKQLLEL 134

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1254 KETQDqLLESQKKEKQLQEEAAKLSGELQQVQ-EANGDIKDSLVKVEELvkvlEEKLQAATSQLDAQQATNKELQELLVK 1332
Cdd:pfam15905  135 TRVNE-LLKAKFSEDGTQKKMSSLSMELMKLRnKLEAKMKEVMAKQEGM----EGKLQVTQKNLEHSKGKVAQLEEKLVS 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1333 S--QENEGNLQGESL--------AVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHN-------- 1394
Cdd:pfam15905  210 TekEKIEEKSETEKLleyitelsCVSEQVEKYKLDIAQLEELLKEKNDEIESLKQSLEEKEQELSKQIKDLNekcklles 289

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 442628156  1395 EIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQK 1433
Cdd:pfam15905  290 EKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQQ 328
RecN COG0497
DNA repair ATPase RecN [Replication, recombination and repair];
1194-1454 2.91e-04

DNA repair ATPase RecN [Replication, recombination and repair];


Pssm-ID: 440263 [Multi-domain]  Cd Length: 555  Bit Score: 45.45  E-value: 2.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1194 KEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSsIIEAQNTKLNESNvqlenktscLKETQDQLLESqkkEKQLQEE 1273
Cdd:COG0497   154 EELLEEYREAYRAWRALKKELEELRADEAERARELD-LLRFQLEELEAAA---------LQPGEEEELEE---ERRRLSN 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1274 AAKLSGELQQVQEAngdIKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVT---EK 1350
Cdd:COG0497   221 AEKLREALQEALEA---LSGGEGGALDLLGQALRALERLAEYDPSLAELAERLESALIELEEAASELRRYLDSLEfdpER 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1351 LQQLEQANGELKeALCQKENG--------LKELQGKLDEsntvLESqkkshneIQDKLEQAQQKERTLQEETSKLAEQLS 1422
Cdd:COG0497   298 LEEVEERLALLR-RLARKYGVtveellayAEELRAELAE----LEN-------SDERLEELEAELAEAEAELLEAAEKLS 365

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 442628156 1423 QL-KQANEELQKSLQQ--KQLLLEKGnEFDTQLAE 1454
Cdd:COG0497   366 AArKKAAKKLEKAVTAelADLGMPNA-RFEVEVTP 399
COG5022 COG5022
Myosin heavy chain [General function prediction only];
557-877 2.95e-04

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 45.84  E-value: 2.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  557 TRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEIL---QTEVRMRDEQIRELNQQLDEVTTQLNVQKAD---- 629
Cdd:COG5022   829 EKKLRETEEVEFSLKAEVLIQKFGRSLKAKKRFSLLKKETIYlqsAQRVELAERQLQELKIDVKSISSLKLVNLELesei 908

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  630 ---SSALDDMLRLQKEGTEEKSTLLEKTEKElVQSKEQAAKTLNDKEQLEK---QISDLKQLAEQEKLVREMTENAINQI 703
Cdd:COG5022   909 ielKKSLSSDLIENLEFKTELIARLKKLLNN-IDLEEGPSIEYVKLPELNKlheVESKLKETSEEYEDLLKKSTILVREG 987

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  704 QLEKESIE---QQLALKQNELEDFQKKQSESEVHLQEI--KAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALE 778
Cdd:COG5022   988 NKANSELKnfkKELAELSKQYGALQESTKQLKELPVEVaeLQSASKIISSESTELSILKPLQKLKGLLLLENNQLQARYK 1067

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  779 ELKKEKETIIKEKEQELQQLQSKSAESESALKvvqvqleqlqqQAAASGEEGSKTVAKLHDEISQLKSQAEETQSE--LK 856
Cdd:COG5022  1068 ALKLRRENSLLDDKQLYQLESTENLLKTINVK-----------DLEVTNRNLVKPANVLQFIVAQMIKLNLLQEISkfLS 1136

                         330       340
                  ....*....|....*....|.
gi 442628156  857 STQSNLEAKSKQLEAANGSLE 877
Cdd:COG5022  1137 QLVNTLEPVFQKLSVLQLELD 1157
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1360-1549 3.09e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.21  E-value: 3.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1360 ELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEEtskLAEQLSQLKQANEELQKSLQQKQ 1439
Cdd:COG3883    20 AKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAE---IAEAEAEIEERREELGERARALY 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1440 -------------------------LLLEKGNEFDTQ-LAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDA 1493
Cdd:COG3883    97 rsggsvsyldvllgsesfsdfldrlSALSKIADADADlLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQ 176

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 442628156 1494 QKTAYLETKELRRQLESLELEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLA 1549
Cdd:COG3883   177 QAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAA 232
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1136-1363 3.28e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 44.52  E-value: 3.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1136 EADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKE 1215
Cdd:COG1340    19 ELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEERDELNEKLNELREELDELR 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1216 ELVQNLEEKVRESSSI---IEAQNTKLNESNVQLENKTSCLKETQD--QLLESQKKEKQLQEEAAKLSGELQQVQEANGD 1290
Cdd:COG1340    99 KELAELNKAGGSIDKLrkeIERLEWRQQTEVLSPEEEKELVEKIKEleKELEKAKKALEKNEKLKELRAELKELRKEAEE 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442628156 1291 IKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKE 1363
Cdd:COG1340   179 IHKKIKELAEEAQELHEEMIELYKEADELRKEADELHKEIVEAQEKADELHEEIIELQKELRELRKELKKLRK 251
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1218-1525 3.39e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 45.71  E-value: 3.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1218 VQNLEEKVRESSSIIEAQNTKLNESNVQLENKTScLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEA---------- 1287
Cdd:COG3096   274 MRHANERRELSERALELRRELFGARRQLAEEQYR-LVEMARELEELSARESDLEQDYQAASDHLNLVQTAlrqqekiery 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1288 NGDIKDSLVKVEELVKVLE---EKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQAngelkEA 1364
Cdd:COG3096   353 QEDLEELTERLEEQEEVVEeaaEQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTRAIQYQQAVQALEKA-----RA 427

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1365 LCQK--------ENGLKELQGKLDE-SNTVLESQKK------SHNEIQDKLE------------QAQQKERTLQE---ET 1414
Cdd:COG3096   428 LCGLpdltpenaEDYLAAFRAKEQQaTEEVLELEQKlsvadaARRQFEKAYElvckiageversQAWQTARELLRryrSQ 507

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1415 SKLAEQLSQLKQANEELQKSLQQKQlllekgnEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQ 1494
Cdd:COG3096   508 QALAQRLQQLRAQLAELEQRLRQQQ-------NAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQR 580

                         330       340       350
                  ....*....|....*....|....*....|.
gi 442628156 1495 KTAYLETKELRRQLESLElekSREVLSLKAQ 1525
Cdd:COG3096   581 SELRQQLEQLRARIKELA---ARAPAWLAAQ 608
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 347-1046 3.69e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 45.34  E-value: 3.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   347 MQDLLREKQQHVEKLMVERDldredAQNQALQLQKNINELKARIVEL---ESALDNERKKTEeLQCSIDEAQFCGDELNA 423
Cdd:TIGR00618  231 LREALQQTQQSHAYLTQKRE-----AQEEQLKKQQLLKQLRARIEELraqEAVLEETQERIN-RARKAAPLAAHIKAVTQ 304

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   424 QSQVYKEKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRENVKYL 503
Cdd:TIGR00618  305 IEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTL 384

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   504 NEQIATLQSELVSKDEALEKFSlsecgiENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQnlkatsds 583
Cdd:TIGR00618  385 QQQKTTLTQKLQSLCKELDILQ------REQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCT-------- 450

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   584 leservnktdeceilQTEVRMRDEQIRELNQQLDEvttqlnvqkadssalddmlRLQKEGTEEKSTLLEKTEKELVQSKE 663
Cdd:TIGR00618  451 ---------------AQCEKLEKIHLQESAQSLKE-------------------REQQLQTKEQIHLQETRKKAVVLARL 496

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   664 QaaktlndkEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKesIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNT 743
Cdd:TIGR00618  497 L--------ELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQR--GEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQ 566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   744 QKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQA 823
Cdd:TIGR00618  567 EIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLT 646

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   824 AASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAA 903
Cdd:TIGR00618  647 ALHALQLTLTQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENA 726

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   904 LSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHK 983
Cdd:TIGR00618  727 SSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEA 806

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442628156   984 ELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAK 1046
Cdd:TIGR00618  807 EIGQEIPSDEDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQA 869
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1024-1415 3.88e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 44.95  E-value: 3.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1024 GERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANA 1103
Cdd:COG5185   177 KKLEIFGLTLGLLKGISELKKAEPSGTVNSIKESETGNLGSESTLLEKAKEIINIEEALKGFQDPESELEDLAQTSDKLE 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1104 NISATNAELSTVLEVLQAEKSE-----TNHIFELFEMEADMNSERLIEKVTGIKEELKETHLQldeRQKKFEELEEKLKQ 1178
Cdd:COG5185   257 KLVEQNTDLRLEKLGENAESSKrlnenANNLIKQFENTKEKIAEYTKSIDIKKATESLEEQLA---AAEAEQELEESKRE 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1179 AQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNlEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKET-Q 1257
Cdd:COG5185   334 TETGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVELSKS-SEELDSFKDTIESTKESLDEIPQNQRGYAQEILATlE 412

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1258 DQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLeeklqaatSQLDAQQATNKELQELLVKSQENE 1337
Cdd:COG5185   413 DTLKAADRQIEELQRQIEQATSSNEEVSKLLNELISELNKVMREADEE--------SQSRLEEAYDEINRSVRSKKEDLN 484

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1338 GNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTV--LESQKKSHNEIQDKLEQAQQKERTLQEETS 1415
Cdd:COG5185   485 EELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFMRArgYAHILALENLIPASELIQASNAKTDGQAAN 564
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
591-790 3.92e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 3.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  591 KTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKA---DSSALDDMLRLQKEgteekstlLEKTEKELvqskEQAAK 667
Cdd:COG4913   615 LEAELAELEEELAEAEERLEALEAELDALQERREALQRlaeYSWDEIDVASAERE--------IAELEAEL----ERLDA 682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  668 TLNDKEQLEKQISDLKQLAEQeklvremTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDF 747
Cdd:COG4913   683 SSDDLAALEEQLEELEAELEE-------LEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERF 755

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 442628156  748 ELVESGESLKKLQQQLEQKTlghEKLQAALEELKKEKETIIKE 790
Cdd:COG4913   756 AAALGDAVERELRENLEERI---DALRARLNRAEEELERAMRA 795
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1022-1216 4.52e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.44  E-value: 4.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1022 AEGERKEKSFEESIKNLQEEVTKAKTENLELstgtQTTIKDLQERLEITNAELQHKEKmasEDAQKIADLKTLVEAIQVA 1101
Cdd:COG3883    26 SELQAELEAAQAELDALQAELEELNEEYNEL----QAELEALQAEIDKLQAEIAEAEA---EIEERREELGERARALYRS 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1102 NANISATNAelstvleVLQAEK-SETNHIFELFEMEADMNSErLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQ 1180
Cdd:COG3883    99 GGSVSYLDV-------LLGSESfSDFLDRLSALSKIADADAD-LLEELKADKAELEAKKAELEAKLAELEALKAELEAAK 170

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 442628156 1181 QSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEE 1216
Cdd:COG3883   171 AELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELA 206
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
557-806 4.56e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 4.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  557 TRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQT---------EVRMRDEQIRELNQQLDEVTtqlnvqk 627
Cdd:COG4913   609 RAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRlaeyswdeiDVASAEREIAELEAELERLD------- 681

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  628 ADSSALDdmlRLQKEgteekstlLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQI---- 703
Cdd:COG4913   682 ASSDDLA---ALEEQ--------LEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLElral 750

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  704 ------QLEKESIEQQLALK-QNELEDFQKKQSESEVHLQEIKAQ-NTQKDFELVESGESLKKLQQQLEQktlgHEKLQA 775
Cdd:COG4913   751 leerfaAALGDAVERELRENlEERIDALRARLNRAEEELERAMRAfNREWPAETADLDADLESLPEYLAL----LDRLEE 826

                         250       260       270
                  ....*....|....*....|....*....|...
gi 442628156  776 -ALEELKKE-KETIIKEKEQELQQLQSKSAESE 806
Cdd:COG4913   827 dGLPEYEERfKELLNENSIEFVADLLSKLRRAI 859
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1407-1576 4.56e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 4.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1407 ERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLL---EKGNEFDTQLAEYQkVIDEMDDAASV--KSALLEQLQNRVA 1481
Cdd:COG4913   220 EPDTFEAADALVEHFDDLERAHEALEDAREQIELLEpirELAERYAAARERLA-ELEYLRAALRLwfAQRRLELLEAELE 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1482 ELETALRQANDAQKtayletkELRRQLESLEleksREVLSLKAQMNGASsrsgkGDEVESLDietslAKINFLNSIIADM 1561
Cdd:COG4913   299 ELRAELARLEAELE-------RLEARLDALR----EELDELEAQIRGNG-----GDRLEQLE-----REIERLERELEER 357

                         170
                  ....*....|....*
gi 442628156 1562 QQKNDALKAKVQTLE 1576
Cdd:COG4913   358 ERRRARLEALLAALG 372
PRK11637 PRK11637
AmiB activator; Provisional
 1193-1429 5.11e-04

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 44.68  E-value: 5.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1193 SKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKlnesnvqlenktscLKETQDQLLESQKKEKQLQE 1272
Cdd:PRK11637   45 NRDQLKSIQQDIAAKEKSVRQQQQQRASLLAQLKKQEEAISQASRK--------------LRETQNTLNQLNKQIDELNA 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1273 EAAKLsgELQQVQeangdikdslvkveelvkvlEEKLQAAtsQLDA--QQATNKELQELLvksqENEGNLQGESL----- 1345
Cdd:PRK11637  111 SIAKL--EQQQAA--------------------QERLLAA--QLDAafRQGEHTGLQLIL----SGEESQRGERIlayfg 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1346 ----AVTEKLQQLEQANGELKEalcQKenglKELQGKLDESNTVLESQKKShneiQDKLEQAQQ-KERTLQEETSKLAE- 1419
Cdd:PRK11637  163 ylnqARQETIAELKQTREELAA---QK----AELEEKQSQQKTLLYEQQAQ----QQKLEQARNeRKKTLTGLESSLQKd 231

                         250
                  ....*....|..
gi 442628156 1420 --QLSQLKQaNE 1429
Cdd:PRK11637  232 qqQLSELRA-NE 242
PRK01156 PRK01156
chromosome segregation protein; Provisional
 944-1444 5.16e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 44.89  E-value: 5.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  944 DKVKEITDtlhaELQAERSSSSALHTKLSKFSDEIATGHKELTSkaDAWSQEMLQKEKElqELRQQLQDSQDSQTKLKAE 1023
Cdd:PRK01156  169 DKLKDVID----MLRAEISNIDYLEEKLKSSNLELENIKKQIAD--DEKSHSITLKEIE--RLSIEYNNAMDDYNNLKSA 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1024 GERKeKSFEESIKNLQEEVTKAKTEnLELSTGTQTTIKDLQERL-EITNAELQHKEKMASEDAQKIADLKTLVEAIQVAN 1102
Cdd:PRK01156  241 LNEL-SSLEDMKNRYESEIKTAESD-LSMELEKNNYYKELEERHmKIINDPVYKNRNYINDYFKYKNDIENKKQILSNID 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1103 ANISATNAELSTvLEVLQAEKSE-----------TNHIFELFEMEADMNS-----ERLIEKV-----------TGIKEEL 1155
Cdd:PRK01156  319 AEINKYHAIIKK-LSVLQKDYNDyikkksryddlNNQILELEGYEMDYNSylksiESLKKKIeeyskniermsAFISEIL 397

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1156 KETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQEL------------------QDSVKQKEEL 1217
Cdd:PRK01156  398 KIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLngqsvcpvcgttlgeeksNHIINHYNEK 477

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1218 VQNLEEKVREsssiIEAQNTKLNESNVQLENKTSCLK-------ETQDQLLESQKKE-KQLQEEAAKLSGELQQVQEANG 1289
Cdd:PRK01156  478 KSRLEEKIRE----IEIEVKDIDEKIVDLKKRKEYLEseeinksINEYNKIESARADlEDIKIKINELKDKHDKYEEIKN 553

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1290 DIKDslVKVEELVKVLEE--KLQAATSQLDAQ------QATNKELQELLVKSQENEGNLQGESLAVTEKLQQLE------ 1355
Cdd:PRK01156  554 RYKS--LKLEDLDSKRTSwlNALAVISLIDIEtnrsrsNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIEneannl 631

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1356 -------QANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQAN 1428
Cdd:PRK01156  632 nnkyneiQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRTRI 711

                         570
                  ....*....|....*.
gi 442628156 1429 EELQKSLQQKQLLLEK 1444
Cdd:PRK01156  712 NELSDRINDINETLES 727
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1142-1463 5.37e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.12  E-value: 5.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1142 ERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNL 1221
Cdd:COG4372    48 EQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1222 EEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEEL 1301
Cdd:COG4372   128 EQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEK 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1302 VKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDE 1381
Cdd:COG4372   208 LIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEA 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1382 SNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDE 1461
Cdd:COG4372   288 LEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGAEAGV 367


                  ..
gi 442628156 1462 MD 1463
Cdd:COG4372   368 AD 369
46 PHA02562
endonuclease subunit; Provisional
 1194-1441 5.78e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 44.62  E-value: 5.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1194 KEKLTEIQQSLQEL---QDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQL-ENKTSCLKETQDQLLEsqkkekq 1269
Cdd:PHA02562  173 KDKIRELNQQIQTLdmkIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEaKTIKAEIEELTDELLN------- 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1270 LQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEE--KLQAATSQLDaqqatnkELQELLVKSQENEGNLQGESLAV 1347
Cdd:PHA02562  246 LVMDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKMYEKggVCPTCTQQIS-------EGPDRITKIKDKLKELQHSLEKL 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1348 TEKLQQLEQANGELKEAlcQKEngLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQA 1427
Cdd:PHA02562  319 DTAIDELEEIMDEFNEQ--SKK--LLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKIVKT 394

                         250
                  ....*....|....
gi 442628156 1428 NEELQKSLQQKQLL 1441
Cdd:PHA02562  395 KSELVKEKYHRGIV 408
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 892-1263 5.79e-04

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 44.46  E-value: 5.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   892 KLKSEVGETQAALsschTDVESKTKQLeaaNAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKL 971
Cdd:pfam06160   83 KAKKALDEIEELL----DDIEEDIKQI---LEELDELLESEEKNREEVEELKDKYRELRKTLLANRFSYGPAIDELEKQL 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   972 SKFSDEIATgHKELTSKAD-AWSQEMLQK-EKELQELRQQLQDSQDSQTKLK----------AEGERK---------EKS 1030
Cdd:pfam06160  156 AEIEEEFSQ-FEELTESGDyLEAREVLEKlEEETDALEELMEDIPPLYEELKtelpdqleelKEGYREmeeegyaleHLN 234

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1031 FEESIKNLQEEV--TKAKTENLELsTGTQTTIKDLQERLEiTNAELQHKEKMASEDAQKiaDLKTLVEAIQVANANISAT 1108
Cdd:pfam06160  235 VDKEIQQLEEQLeeNLALLENLEL-DEAEEALEEIEERID-QLYDLLEKEVDAKKYVEK--NLPEIEDYLEHAEEQNKEL 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1109 NAELSTVLE--VLQAEKSETNHIFE--LFEMEADMNS--ERLIEKV---TGIKEELKETHLQLDERQKKFEELEEKLKQA 1179
Cdd:pfam06160  311 KEELERVQQsyTLNENELERVRGLEkqLEELEKRYDEivERLEEKEvaySELQEELEEILEQLEEIEEEQEEFKESLQSL 390

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1180 QQSEQKLQQESQTSKEKLTEIQQSL---------QELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENkt 1250
Cdd:pfam06160  391 RKDELEAREKLDEFKLELREIKRLVeksnlpglpESYLDYFFDVSDEIEDLADELNEVPLNMDEVNRLLDEAQDDVDT-- 468

                          410
                   ....*....|...
gi 442628156  1251 scLKETQDQLLES 1263
Cdd:pfam06160  469 --LYEKTEELIDN 479
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 649-884 6.06e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.05  E-value: 6.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  649 TLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDF---Q 725
Cdd:COG3883    16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERaraL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  726 KKQSESEVHLQEIKAQNTQKDFelVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAES 805
Cdd:COG3883    96 YRSGGSVSYLDVLLGSESFSDF--LDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442628156  806 ESALKVVQVQLEQLqqqaaasgeegSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSG 884
Cdd:COG3883   174 EAQQAEQEALLAQL-----------SAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 241
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 370-1189 6.21e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 44.78  E-value: 6.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   370 EDAQNQALQLQKNINELKARIVELESALDNERKK-----------TEELQCSIDEAQFCGDELNAQsqvykekiHDLESK 438
Cdd:pfam01576  253 EEETAQKNNALKKIRELEAQISELQEDLESERAArnkaekqrrdlGEELEALKTELEDTLDTTAAQ--------QELRSK 324

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   439 ITKLVSatpSLQSILPPDLPSDDGALQEeiaklqekMTIQQKEVESRIAEQLEEEQRLRENvkyLNEQIATLQSElvSKD 518
Cdd:pfam01576  325 REQEVT---ELKKALEEETRSHEAQLQE--------MRQKHTQALEELTEQLEQAKRNKAN---LEKAKQALESE--NAE 388

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   519 EALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEftRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEIL 598
Cdd:pfam01576  389 LQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESE--RQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSL 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   599 QTEVRMRDEQIRELNQQLDEVTTQLnvqkadssalddmlrlqKEGTEEKSTLLEKTEKElVQSKEQAAKTLndkEQLEKQ 678
Cdd:pfam01576  467 ESQLQDTQELLQEETRQKLNLSTRL-----------------RQLEDERNSLQEQLEEE-EEAKRNVERQL---STLQAQ 525

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   679 ISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAqNTQKDFELVesgESLKK 758
Cdd:pfam01576  526 LSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLV-DLDHQRQLV---SNLEK 601

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   759 LQQQLEQkTLGHEKLQAA--------LEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGE-- 828
Cdd:pfam01576  602 KQKKFDQ-MLAEEKAISAryaeerdrAEAEAREKETRALSLARALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKnv 680

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   829 -EGSKTVAKLHDEISQLKSQAEETQSELKSTQS-------NLEAK----------------------SKQLEAANGSLEE 878
Cdd:pfam01576  681 hELERSKRALEQQVEEMKTQLEELEDELQATEDaklrlevNMQALkaqferdlqardeqgeekrrqlVKQVRELEAELED 760

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   879 EAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHA--- 955
Cdd:pfam01576  761 ERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLKKLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNlea 840

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   956 ---ELQAERSSSSALHTKLSKFSDEIAtghKELTSKADawSQEMLQKEKELQELRqqlqdsqdsQTKLKAEGERKEKSFE 1032
Cdd:pfam01576  841 ellQLQEDLAASERARRQAQQERDELA---DEIASGAS--GKSALQDEKRRLEAR---------IAQLEEELEEEQSNTE 906

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1033 ESIKNLQEEVTKAKTENLELSTGTQTTIK--DLQERLEITNAELqhKEKMASEDAQKIADLKTLVEAIQvananisATNA 1110
Cdd:pfam01576  907 LLNDRLRKSTLQVEQLTTELAAERSTSQKseSARQQLERQNKEL--KAKLQEMEGTVKSKFKSSIAALE-------AKIA 977

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1111 ELSTVLEVLQAEKSETNHIF-----ELFEMEADMNSERliEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQK 1185
Cdd:pfam01576  978 QLEEQLEQESRERQAANKLVrrtekKLKEVLLQVEDER--RHADQYKDQAEKGNSRMKQLKRQLEEAEEEASRANAARRK 1055


                   ....
gi 442628156  1186 LQQE 1189
Cdd:pfam01576 1056 LQRE 1059
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1141-1363 6.74e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 44.43  E-value: 6.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1141 SERLIEKVtgiKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQElqdsvkQKEELVQN 1220
Cdd:PRK00409  500 PENIIEEA---KKLIGEDKEKLNELIASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQE------EEDKLLEE 570

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1221 LEEKVREsssIIEAqntklnesnvqlenktscLKETQDQLLesqkKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEE 1300
Cdd:PRK00409  571 AEKEAQQ---AIKE------------------AKKEADEII----KELRQLQKGGYASVKAHELIEARKRLNKANEKKEK 625

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442628156 1301 LVKVLEEKlqaatsqldaqqatNKELQ--------------ELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKE 1363
Cdd:PRK00409  626 KKKKQKEK--------------QEELKvgdevkylslgqkgEVLSIPDDKEAIVQAGIMKMKVPLSDLEKIQKPKKK 688
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 378-752 6.79e-04

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 44.66  E-value: 6.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  378 QLQKNINELKARIVE-LESALD--NERKKTEElqcSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLvsatpslqsilP 454
Cdd:PRK10929   34 QAKAAKTPAQAEIVEaLQSALNwlEERKGSLE---RAKQYQQVIDNFPKLSAELRQQLNNERDEPRSV-----------P 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  455 PDLPSDDgaLQEEIAKLQEKMTIQqkevesriAEQLEEEQ-RLRENVKYLNeQIATLQSELvskdealeKFSLSEcgIEN 533
Cdd:PRK10929  100 PNMSTDA--LEQEILQVSSQLLEK--------SRQAQQEQdRAREISDSLS-QLPQQQTEA--------RRQLNE--IER 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  534 LRRELELLKEEnekqaqEAQAEFTRKLAEKSVevlrlsselqnLKATSDSLESERVNKTDECEIlqteVRMRDE----QI 609
Cdd:PRK10929  159 RLQTLGTPNTP------LAQAQLTALQAESAA-----------LKALVDELELAQLSANNRQEL----ARLRSElakkRS 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  610 RELNQQLDEVTTQLNV--QKADSSALDDMLRLQKEGTEEKSTLLE--KTEKELVQSKEQAAKTLND-------------- 671
Cdd:PRK10929  218 QQLDAYLQALRNQLNSqrQREAERALESTELLAEQSGDLPKSIVAqfKINRELSQALNQQAQRMDLiasqqrqaasqtlq 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  672 --------KEQ-------------LEKQISDLKQLAEQEKLVREMTENAINQIQLEkESIEQQLALKQNELEDFQKKQSE 730
Cdd:PRK10929  298 vrqalntlREQsqwlgvsnalgeaLRAQVARLPEMPKPQQLDTEMAQLRVQRLRYE-DLLNKQPQLRQIRQADGQPLTAE 376

                         410       420
                  ....*....|....*....|...
gi 442628156  731 SEVHLQE-IKAQNtqkdfELVES 752
Cdd:PRK10929  377 QNRILDAqLRTQR-----ELLNS 394
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1312-1497 6.90e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.05  E-value: 6.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1312 ATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKK 1391
Cdd:COG3883    14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERAR 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1392 S----------------HNEIQDKLEQAQQKERtLQEETSKLAEQLSQLKQANEELQKSLQQKQlllekgNEFDTQLAEY 1455
Cdd:COG3883    94 AlyrsggsvsyldvllgSESFSDFLDRLSALSK-IADADADLLEELKADKAELEAKKAELEAKL------AELEALKAEL 166

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 442628156 1456 QKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTA 1497
Cdd:COG3883   167 EAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAA 208
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 773-1503 7.54e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 44.43  E-value: 7.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   773 LQAALEELKKEKETIIKekeqELQQLQSKSAESESALKVVQVQLEQLQQQAAAsgEEGSKtvaklhdeISQLKSQAEETQ 852
Cdd:pfam10174    1 LQAQLRDLQRENELLRR----ELDIKESKLGSSMNSIKTFWSPELKKERALRK--EEAAR--------ISVLKEQYRVTQ 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   853 SELKSTQSNLEAKSKQLEAA---NGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHtdvESKTKQLEAANAALEKVN 929
Cdd:pfam10174   67 EENQHLQLTIQALQDELRAQrdlNQLLQQDFTTSPVDGEDKFSTPELTEENFRRLQSEH---ERQAKELFLLRKTLEEME 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   930 KEYAESRAEASDLQDKVKEITDTLHaelqaerssSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQ 1009
Cdd:pfam10174  144 LRIETQKQTLGARDESIKKLLEMLQ---------SKGLPKKSGEEDWERTRRIAEAEMQLGHLEVLLDQKEKENIHLREE 214

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1010 ---LQDSQDSQTKLKA------EGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKM 1080
Cdd:pfam10174  215 lhrRNQLQPDPAKTKAlqtvieMKDTKISSLERNIRDLEDEVQMLKTNGLLHTEDREEEIKQMEVYKSHSKFMKNKIDQL 294

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1081 ASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNhifeLFEMEADMNSERLIEKVTgikeelkethl 1160
Cdd:pfam10174  295 KQELSKKESELLALQTKLETLTNQNSDCKQHIEVLKESLTAKEQRAA----ILQTEVDALRLRLEEKES----------- 359

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1161 QLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVR---ESSSIIEAQNT 1237
Cdd:pfam10174  360 FLNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQLAGLKERVKslqTDSSNTDTALT 439

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1238 KLNESNVQLENKTSCLKETQDQL-------LESQKKE-KQLQEEAAKLSGELQQ-------VQEANGDIKDSLVKVEELV 1302
Cdd:pfam10174  440 TLEEALSEKERIIERLKEQREREdrerleeLESLKKEnKDLKEKVSALQPELTEkesslidLKEHASSLASSGLKKDSKL 519

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1303 KVLEEKLQAATSQLDAQQATNKELQELLVKSQENEgnlqgeslAVTEKLQQLEQANGELKE--ALCQKE-----NGLKEL 1375
Cdd:pfam10174  520 KSLEIAVEQKKEECSKLENQLKKAHNAEEAVRTNP--------EINDRIRLLEQEVARYKEesGKAQAEverllGILREV 591

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1376 QG-KLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLllekgnefDTQLAE 1454
Cdd:pfam10174  592 ENeKNDKDKKIAELESLTLRQMKEQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQL--------EELMGA 663

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*....
gi 442628156  1455 YQKVIDEMDDAASVKSALLEQLQNRVAELeTALRQANDAQKTAYLETKE 1503
Cdd:pfam10174  664 LEKTRQELDATKARLSSTQQSLAEKDGHL-TNLRAERRKQLEEILEMKQ 711
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 609-989 7.69e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 44.23  E-value: 7.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  609 IRELNQQLDEVTTQLNVqkadsSALDDMLRLQKEGTEEKSTLLEKTEKELvqSKEQAAKTLNDKEQLEKQISDL-KQLAE 687
Cdd:NF033838   71 LSEIQKSLDKRKHTQNV-----ALNKKLSDIKTEYLYELNVLKEKSEAEL--TSKTKKELDAAFEQFKKDTLEPgKKVAE 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  688 QEKLVREMTENAINQIQlEKESIEQQLALKQNELE--DFQKKQSESEVHLQEIKAQNTQKDfelvesgESLKKLQQQLEQ 765
Cdd:NF033838  144 ATKKVEEAEKKAKDQKE-EDRRNYPTNTYKTLELEiaESDVEVKKAELELVKEEAKEPRDE-------EKIKQAKAKVES 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  766 KtlgheklQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLK 845
Cdd:NF033838  216 K-------KAEATRLEKIKTDREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDS 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  846 SQAEET--QSELKSTQSNLEAKSKQLEAangslEEEAKksghlleqitKLKSEVGETQAALSSCHTDVESKTKQLEAANA 923
Cdd:NF033838  289 SVGEETlpSPSLKPEKKVAEAEKKVEEA-----KKKAK----------DQKEEDRRNYPTNTYKTLELEIAESDVKVKEA 353

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442628156  924 ALEKVNKEYAESRAEasdlqDKVKEItdtlhaelQAERSSSSALHTKLSKFSDEIATGHKELTSKA 989
Cdd:NF033838  354 ELELVKEEAKEPRNE-----EKIKQA--------KAKVESKKAEATRLEKIKTDRKKAEEEAKRKA 406
ClyA-like cd21116
family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including ...
 1175-1323 8.55e-04

family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including Bacillus cereus HblB, Aeromonas hydrophila AhlB, Bacillus thuringiensis Cry6Aa and similar proteins; This family belongs to the ClyA family of alpha-PFT bacterial toxins. PFTs form the major group of virulence factors in many pathogenic bacteria and in general are critical components of the molecular offensive and defensive machinery of cells in all kingdoms of life. Bacterial PFTs facilitate the takeover of host resources by puncturing holes in the membrane. PFTs can be classified as alpha-PFTs and beta-PFTs depending on the secondary structures of their membrane component. Alpha-PFTs use a ring of amphipathic helices while beta-PFTs use a beta-barrel to construct the pore. Members of this family include the toxins: Bacillus cereus hemolysin binding component B (HblB or HBL-B) of the diarrheal enterotoxin hemolysin BL, Aeromonas hydrophila hemolytic (Ahl) component B (AhlB) of the tripartite AhlABC toxin, Vibrio cholerae cytotoxin motility associated killing factor A (MakA) cytotoxin, Xenorhabdus nematophila alpha-xenorhabdolysin (XaxA), Bacillus thuringiensis crystal 6Aa (Cry6Aa) parasporal crystal (Cry) toxin, and Bacillus cereus non-hemolytic enterotoxin (Nhe) component A (NheA) of the non-hemolytic enterotoxin Nhe, which, despite its name, is hemolytic, among others. In solution, ClyA proteins have an elongated, almost entirely alpha-helical structure, except for a short hydrophobic beta-hairpin known as the beta-tongue. Pore formation by ClyA requires circular oligomerization of the toxin by a sequential mechanism. This, in turn, concentrates the amphipathic helices in the center of the ring-like structure, forming a helical barrel that inserts into the membrane by a wedge-like mechanism. Compared with ClyA, NheA is almost entirely alpha-helical with an enlarged "head" domain, and an enlarged beta-tongue; it has been proposed that NheA could even form beta-barrel pores. Alpha-PFTs with similar structures are increasingly being found in eukaryotes, in particular as components of the immune systems of animals. This family may be distantly related to Escherichia coli alpha-PFT hemolysin E (HlyE, also known as ClyA or SheA).


Pssm-ID: 439149 [Multi-domain]  Cd Length: 224  Bit Score: 42.79  E-value: 8.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1175 KLKQAQQSEQKLQQESQTSKEKLteiQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLK 1254
Cdd:cd21116    74 YYPDLIELADNLIKGDQGAKQQL---LQGLEALQSQVTKKQTSVTSFINELTTFKNDLDDDSRNLQTDATKAQAQVAVLN 150

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442628156 1255 ETQDQLlesqkkeKQLQEEAAKLSGELQQVQEANGDIKDSLvkveelvKVLEEKLQAATSQLDAQQATN 1323
Cdd:cd21116   151 ALKNQL-------NSLAEQIDAAIDALEKLSNDWQTLDSDI-------KELITDLEDAESSIDAAFLQA 205
COG4487 COG4487
Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];
646-806 9.84e-04

Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];


Pssm-ID: 443580 [Multi-domain]  Cd Length: 425  Bit Score: 43.40  E-value: 9.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  646 EKSTLLEKTEKELVQSKEQAAKTLNDK-EQLEKQISDLKQ-----LAEQEKLVREMTENAINQIQLEKESIEQQLALKQN 719
Cdd:COG4487    37 ERLADAAKREAALELAEAKAKAQLQEQvAEKDAEIAELRArleaeERKKALAVAEEKEKELAALQEALAEKDAKLAELQA 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  720 ELEDFQKKQSESEVHLQEIKAQnTQKdfELVESGESLK-KLQQQLEQKTLGHEKLQAA-----LEELKKEKETIIKEKEQ 793
Cdd:COG4487   117 KELELLKKERELEDAKREAELT-VEK--ERDEELDELKeKLKKEEEEKQLAEKSLKVAeyekqLKDMQEQIEELKRKKEQ 193

                         170
                  ....*....|...
gi 442628156  794 ELQQLQSKSAESE 806
Cdd:COG4487   194 GSTQLQGEVLELE 206
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1073-1545 9.98e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 44.04  E-value: 9.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1073 ELQHKEKMASEDAQKIADLKTLVEAIQvananisATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEKVTGIK 1152
Cdd:pfam10174   40 ELKKERALRKEEAARISVLKEQYRVTQ-------EENQHLQLTIQALQDELRAQRDLNQLLQQDFTTSPVDGEDKFSTPE 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1153 EELKETHLQLDERQKKFEELEekLKQAQQSEQKLQQESQtsKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSII 1232
Cdd:pfam10174  113 LTEENFRRLQSEHERQAKELF--LLRKTLEEMELRIETQ--KQTLGARDESIKKLLEMLQSKGLPKKSGEEDWERTRRIA 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1233 EAQnTKLNESNVQLENKTsclKETQdQLLESQKKEKQLQEEAAKLSGeLQQVQEAN----GDIKDSLVKVEELVKVLE-- 1306
Cdd:pfam10174  189 EAE-MQLGHLEVLLDQKE---KENI-HLREELHRRNQLQPDPAKTKA-LQTVIEMKdtkiSSLERNIRDLEDEVQMLKtn 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1307 -----EKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGE-------LKEALCQKENGLKE 1374
Cdd:pfam10174  263 gllhtEDREEEIKQMEVYKSHSKFMKNKIDQLKQELSKKESELLALQTKLETLTNQNSDckqhievLKESLTAKEQRAAI 342

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1375 LQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQkqlLLEKGNEFDTQLAE 1454
Cdd:pfam10174  343 LQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIEN---LQEQLRDKDKQLAG 419

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1455 YQKVIDE--------------MDDAASVKSALLEQLQNRVAELETALRQANDAQKTaylETKELRRQLESLE---LEKSR 1517
Cdd:pfam10174  420 LKERVKSlqtdssntdtalttLEEALSEKERIIERLKEQREREDRERLEELESLKK---ENKDLKEKVSALQpelTEKES 496

                          490       500
                   ....*....|....*....|....*....
gi 442628156  1518 EVLSLKAQMNGASSRSGKGD-EVESLDIE 1545
Cdd:pfam10174  497 SLIDLKEHASSLASSGLKKDsKLKSLEIA 525
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
463-850 1.08e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.60  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  463 ALQEEIAKLQEkmtiQQKEVESRIAEQLEEEQRLRENVKYLN--EQIATLQSELVSKDEALEKFSLSECGIENLRRELEL 540
Cdd:COG4717    92 ELQEELEELEE----ELEELEAELEELREELEKLEKLLQLLPlyQELEALEAELAELPERLEELEERLEELRELEEELEE 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  541 LKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVR---------MRDEQIRE 611
Cdd:COG4717   168 LEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEqleneleaaALEERLKE 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  612 LNQQLDEVTTQLNVQKADSSALDDMLRLQK--------------EGTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEK 677
Cdd:COG4717   248 ARLLLLIAAALLALLGLGGSLLSLILTIAGvlflvlgllallflLLAREKASLGKEAEELQALPALEELEEEELEELLAA 327

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  678 -QISDLKQLAEQEKLVREMTEnaINQIQLEKESIEQQLALKQNELE---DFQKKQSESEVHLQEiKAQNTQKDFELVesg 753
Cdd:COG4717   328 lGLPPDLSPEELLELLDRIEE--LQELLREAEELEEELQLEELEQEiaaLLAEAGVEDEEELRA-ALEQAEEYQELK--- 401

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  754 ESLKKLQQQLEQKTLGHEKLQAAL--EELKKEKETI---IKEKEQELQQLQSKSAESESALKVVqvqleqlqqqaaasge 828
Cdd:COG4717   402 EELEELEEQLEELLGELEELLEALdeEELEEELEELeeeLEELEEELEELREELAELEAELEQL---------------- 465

                         410       420
                  ....*....|....*....|..
gi 442628156  829 EGSKTVAKLHDEISQLKSQAEE 850
Cdd:COG4717   466 EEDGELAELLQELEELKAELRE 487
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 576-1482 1.16e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 44.05  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  576 NLKATSDSLESERVNKTDECEILqtevRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEkstllEKTE 655
Cdd:PTZ00440  881 IIKTLNIAINRSNSNKQLVEHLL----NNKIDLKNKLEQHMKIINTDNIIQKNEKLNLLNNLNKEKEKIEK-----QLSD 951

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  656 KELVQSKEQAAKTLNDKEQLEKQISDlKQLAEQEKLVREMTENAINQIQLEKESIEQQLAlkQNELEDFQKKQSESEVHL 735
Cdd:PTZ00440  952 TKINNLKMQIEKTLEYYDKSKENING-NDGTHLEKLDKEKDEWEHFKSEIDKLNVNYNIL--NKKIDDLIKKQHDDIIEL 1028

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  736 ---------QEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETI---IKEKEQELQQLQSKSA 803
Cdd:PTZ00440 1029 idklikekgKEIEEKVDQYISLLEKMKTKLSSFHFNIDIKKYKNPKIKEEIKLLEEKVEALlkkIDENKNKLIEIKNKSH 1108

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  804 ESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEisqLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKS 883
Cdd:PTZ00440 1109 EHVVNADKEKNKQTEHYNKKKKSLEKIYKQMEKTLKE---LENMNLEDITLNEVNEIEIEYERILIDHIVEQINNEAKKS 1185

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  884 GHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAAL---EKVNKEYAESR-----AEASDLQDKVKEITDTLHA 955
Cdd:PTZ00440 1186 KTIMEEIESYKKDIDQVKKNMSKERNDHLTTFEYNAYYDKATasyENIEELTTEAKglkgeANRSTNVDELKEIKLQVFS 1265

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  956 ELQAERSSSSALHTKLSkfsdEIATGHKELTS-KADAWSQEMLQKEKELQELrqqlqdsqdsqtKLKAEGERKEKSfeES 1034
Cdd:PTZ00440 1266 YLQQVIKENNKMENALH----EIKNMYEFLISiDSEKILKEILNSTKKAEEF------------SNDAKKELEKTD--NL 1327

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1035 IKNLQEEVTKAKTENLELSTgtqtTIKDLQERLEITNAELQHKEKMASEDA-----QKIADLKTLVEaIQVANANISATN 1109
Cdd:PTZ00440 1328 IKQVEAKIEQAKEHKNKIYG----SLEDKQIDDEIKKIEQIKEEISNKRKEinkylSNIKSNKEKCD-LHVRNASRGKDK 1402

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1110 AELSTVLEVLQAEKSETNHIFELFEMeadmnserlIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQE 1189
Cdd:PTZ00440 1403 IDFLNKHEAIEPSNSKEVNIIKITDN---------INKCKQYSNEAMETENKADENNDSIIKYEKEITNILNNSSILGKK 1473

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1190 SQTSKEK------LTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLES 1263
Cdd:PTZ00440 1474 TKLEKKKkeatniMDDINGEHSIIKTKLTKSSEKLNQLNEQPNIKREGDVLNNDKSTIAYETIQYNLGRVKHNLLNILNI 1553

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1264 QKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVK------VEELVKVLEEK--LQAATSQLDAQQATNKELQELLVKSQE 1335
Cdd:PTZ00440 1554 KDEIETILNKAQDLMRDISKISKIVENKNLENLNdkeadyVKYLDNILKEKqlMEAEYKKLNEIYSDVDNIEKELKKHKK 1633

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1336 N--EGNLQgeslAVTEKLQQLEQANGELKEALCQKENGLKELQGKLD----ESNTVLESQKKSHNEIQDKLEQAQQKERT 1409
Cdd:PTZ00440 1634 NyeIGLLE----KVIEINKNIKLYMDSTKESLNSLVNNFSSLFNNFYlnkyNINENLEKYKKKLNEIYNEFMESYNIIQE 1709

                         890       900       910       920       930       940       950
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442628156 1410 LQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEF--DTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAE 1482
Cdd:PTZ00440 1710 KMKEVSNDDVDYNEAKTLREEAQKEEVNLNNKEEEAKKYlnDIKKQESFRFILYMKEKLDELSKMCKQQYNIVDE 1784
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2-92 1.24e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156    2 SDDTSASGGTSAPFPSPVTADPEPGATASKLPGPIRSNIPTPATSGTGIPqpskmkAPSSFGSTGSVSKIGRPCCNHTTP 81
Cdd:PHA03307  280 SRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSST------SSSSESSRGAAVSPGPSPSRSPSP 353

                          90
                  ....*....|.
gi 442628156   82 KSGPPPRDNSS 92
Cdd:PHA03307  354 SRPPPPADPSS 364
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 1199-1426 1.29e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 42.70  E-value: 1.29e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   1199 EIQQ-SLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQlLESQK-----KEKQLQE 1272
Cdd:smart00787   66 ELYQfSCKELKKYISEGRDLFKEIEEETLINNPPLFKEYFSASPDVKLLMDKQFQLVKTFAR-LEAKKmwyewRMKLLEG 144

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   1273 EAAKLSGELQQVQEAngdiKDSLVKVEELVKVLEEKLQaatsqlDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQ 1352
Cdd:smart00787  145 LKEGLDENLEGLKED----YKLLMKELELLNSIKPKLR------DRKDALEEELRQLKQLEDELEDCDPTELDRAKEKLK 214

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442628156   1353 QLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTlqeETSKLAEQLSQLKQ 1426
Cdd:smart00787  215 KLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFTFK---EIEKLKEQLKLLQS 285
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
607-1208 1.29e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.75  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  607 EQIRELNQQLDEVTTQLNVQKAdssaLDDMLRLQKEgtEEKSTLLEKtekELVQSKEQAAKTLNDKEQLEKQISDLKQLA 686
Cdd:COG4913   255 EPIRELAERYAAARERLAELEY----LRAALRLWFA--QRRLELLEA---ELEELRAELARLEAELERLEARLDALREEL 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  687 EQeklvremTENAINQIQLE-KESIEQQLALKQNELEDFQKKQSESEVHLQEIkaqntqkDFELVESGESLKKLQQQLEQ 765
Cdd:COG4913   326 DE-------LEAQIRGNGGDrLEQLEREIERLERELEERERRRARLEALLAAL-------GLPLPASAEEFAALRAEAAA 391

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  766 KTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESAlkvvqvqleqlqqqaaasgeeGSKTVAKLHDEISQLK 845
Cdd:COG4913   392 LLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERR---------------------KSNIPARLLALRDALA 450

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  846 SQAEETQSELK------------------------STQSNLEAKSKQLEAANGSLE----------EEAKKSGHLLEQIT 891
Cdd:COG4913   451 EALGLDEAELPfvgelievrpeeerwrgaiervlgGFALTLLVPPEHYAAALRWVNrlhlrgrlvyERVRTGLPDPERPR 530

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  892 --------KLKSEVGETQAALSS---------CHTDVE--------------------------------------SKTK 916
Cdd:COG4913   531 ldpdslagKLDFKPHPFRAWLEAelgrrfdyvCVDSPEelrrhpraitragqvkgngtrhekddrrrirsryvlgfDNRA 610

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  917 QLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSS-----ALHTKLSKFSDEIAtghkeltsKADA 991
Cdd:COG4913   611 KLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDeidvaSAEREIAELEAELE--------RLDA 682

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  992 WSQEMLQKEKELQELRQQLQDSQDSQTKLKaegeRKEKSFEESIKNLQEEVTKAKTENLEL-STGTQTTIKDLQERLEIT 1070
Cdd:COG4913   683 SSDDLAALEEQLEELEAELEELEEELDELK----GEIGRLEKELEQAEEELDELQDRLEAAeDLARLELRALLEERFAAA 758

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1071 NAELQHKEKMASedaqkiadlktLVEAIQVANANISATNAELSTVLEVLQAEksetnHIFELFEMEADMNSerlIEKVTG 1150
Cdd:COG4913   759 LGDAVERELREN-----------LEERIDALRARLNRAEEELERAMRAFNRE-----WPAETADLDADLES---LPEYLA 819

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1151 IKEELKETHLQldERQKKFEELEEKLKQAQQSE--QKLQQESQTSKEKLTEIQQSLQELQ 1208
Cdd:COG4913   820 LLDRLEEDGLP--EYEERFKELLNENSIEFVADllSKLRRAIREIKERIDPLNDSLKRIP 877
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 643-800 1.42e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 43.48  E-value: 1.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   643 GTEEKSTLLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQeklvremTENAINQIQLEKESIEQQLALK----- 717
Cdd:pfam05667  322 KVETEEELQQQREEELEELQEQLEDLESSIQELEKEIKKLESSIKQ-------VEEELEELKEQNEELEKQYKVKkktld 394

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   718 -----QNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKL--------QQQLEQKTLGHEKLQAALEELKKek 784
Cdd:pfam05667  395 llpdaEENIAKLQALVDASAQRLVELAGQWEKHRVPLIEEYRALKEAksnkedesQRKLEEIKELREKIKEVAEEAKQ-- 472

                          170
                   ....*....|....*.
gi 442628156   785 etiikeKEQELQQLQS 800
Cdd:pfam05667  473 ------KEELYKQLVA 482
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 1159-1262 1.54e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 43.15  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1159 HLQLDERQKKFEELEEKLKQAQQSEQKLQQESQT-SKEKLTEIQQSLQELQ---DSVKQKEELVQNLEEKVRESSSIIEA 1234
Cdd:COG0542   403 RMEIDSKPEELDELERRLEQLEIEKEALKKEQDEaSFERLAELRDELAELEeelEALKARWEAEKELIEEIQELKEELEQ 482

                          90       100
                  ....*....|....*....|....*...
gi 442628156 1235 QNTKLNESNVQLENKTSCLKETQDQLLE 1262
Cdd:COG0542   483 RYGKIPELEKELAELEEELAELAPLLRE 510
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 351-658 1.58e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.09  E-value: 1.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   351 LREKQQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKE 430
Cdd:TIGR04523  396 LESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSR 475

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   431 KI----HDLESKITKLVSATPSLQSilppdlpsddgaLQEEIAKLQEKmtiqQKEVESRIAEQLEEEQRLRENVKYLNEQ 506
Cdd:TIGR04523  476 SInkikQNLEQKQKELKSKEKELKK------------LNEEKKELEEK----VKDLTKKISSLKEKIEKLESEKKEKESK 539

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   507 IATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQAqeAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLES 586
Cdd:TIGR04523  540 ISDLEDELNKDDFELKKENLEKEIDEKNKEIEELKQTQKSLKK--KQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEK 617

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442628156   587 ERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKEL 658
Cdd:TIGR04523  618 ELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKIDDIIELMKDWLKEL 689
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1350-1497 1.60e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.83  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1350 KLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQE--ETSKLAEQLSQLKQA 1427
Cdd:COG1579    18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEqlGNVRNNKEYEALQKE 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442628156 1428 NEELQKSLQQ-KQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTA 1497
Cdd:COG1579    98 IESLKRRISDlEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREEL 168
Rabaptin pfam03528
Rabaptin;
1166-1518 1.66e-03

Rabaptin;


Pssm-ID: 367545 [Multi-domain]  Cd Length: 486  Bit Score: 42.79  E-value: 1.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1166 QKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSlqelqdsvkqKEELVQNLEEKVRESSSIIEAQNTKLNESNVQ 1245
Cdd:pfam03528    7 QQRVAELEKENAEFYRLKQQLEAEFNQKRAKFKELYLA----------KEEDLKRQNAVLQEAQVELDALQNQLALARAE 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1246 LENKTSCLKETQDQLLES-QKKEKQLQEEAAKLSGELqqvqeangdiKDSLVKVEELVKVLEEKLQAATSQL-DAQQATN 1323
Cdd:pfam03528   77 MENIKAVATVSENTKQEAiDEVKSQWQEEVASLQAIM----------KETVREYEVQFHRRLEQERAQWNQYrESAEREI 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1324 KELQELLVKSQENEgNLQGESLAVTEKLQQL-------EQANGELKEALCQKENGLKELQG-KLDESNTVLESQKKSHNE 1395
Cdd:pfam03528  147 ADLRRRLSEGQEEE-NLEDEMKKAQEDAEKLrsvvmpmEKEIAALKAKLTEAEDKIKELEAsKMKELNHYLEAEKSCRTD 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1396 iqdkleqaqqkertLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAE-YQKVIDEMDDAASVksaLLE 1474
Cdd:pfam03528  226 --------------LEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHtWQKANDQFLESQRL---LMR 288

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 442628156  1475 QLQNRVAELET-ALRQANDAQKTAYLETKELRRQLESLELEKSRE 1518
Cdd:pfam03528  289 DMQRMESVLTSeQLRQVEEIKKKDQEEHKRARTHKEKETLKSDRE 333
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1057-1287 1.66e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.08  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1057 QTTIKDLQERLEITNA------ELqhkeKMASEDAQKIAD-LKTLVEA-----IQVANANISATNAELSTVLEVLQAEKS 1124
Cdd:COG3206   117 EAAIERLRKNLTVEPVkgsnviEI----SYTSPDPELAAAvANALAEAyleqnLELRREEARKALEFLEEQLPELRKELE 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1125 ETNHIFELFE-----MEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLK--------------------QA 1179
Cdd:COG3206   193 EAEAALEEFRqknglVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQLGsgpdalpellqspviqqlraQL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1180 QQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQ 1259
Cdd:COG3206   273 AELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAE 352

                         250       260
                  ....*....|....*....|....*...
gi 442628156 1260 LLESQKKEKQLQEEAAKLSGELQQVQEA 1287
Cdd:COG3206   353 LRRLEREVEVARELYESLLQRLEEARLA 380
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1268-1576 2.09e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 43.02  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1268 KQLQEEAAKLSGELQQVQEANGDIKDSLVkveELVKVLEEkLQAATSQLDAQ-QATNKELqellvksqenegNLQGESLA 1346
Cdd:COG3096   281 RELSERALELRRELFGARRQLAEEQYRLV---EMARELEE-LSARESDLEQDyQAASDHL------------NLVQTALR 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1347 VTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEEtsklAEQLSQLKQ 1426
Cdd:COG3096   345 QQEKIERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTR----AIQYQQAVQ 420

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1427 ANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVIDE-----------MDDAASVKSALLEQLQNRVAELETA--------- 1486
Cdd:COG3096   421 ALEKARALCGLPDLTPENAEDYLAAFRAKEQQATEevleleqklsvADAARRQFEKAYELVCKIAGEVERSqawqtarel 500

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1487 LRQANDAQKTAYLETkELRRQLESLE--LEKSREVLSLKAQMNGASSRS-GKGDEVESL------DIETSLAKINFLNSI 1557
Cdd:COG3096   501 LRRYRSQQALAQRLQ-QLRAQLAELEqrLRQQQNAERLLEEFCQRIGQQlDAAEELEELlaeleaQLEELEEQAAEAVEQ 579

                         330
                  ....*....|....*....
gi 442628156 1558 IADMQQKNDALKAKVQTLE 1576
Cdd:COG3096   580 RSELRQQLEQLRARIKELA 598
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 1090-1235 2.20e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 41.93  E-value: 2.20e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   1090 DLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNH-IFELFEMEADMNSERLIEkVTGIKEELKETHLQLDERQKK 1168
Cdd:smart00787  148 GLDENLEGLKEDYKLLMKELELLNSIKPKLRDRKDALEEeLRQLKQLEDELEDCDPTE-LDRAKEKLKKLLQEIMIKVKK 226

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442628156   1169 FEELEEKLkqaqqseQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQ 1235
Cdd:smart00787  227 LEELEEEL-------QELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFTFKEIEKLKEQLKLLQSL 286
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
558-799 2.52e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.70  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  558 RKLAEKSVEVLRL--------SSELQNLKATSDSLESERVNKTDeceILQTEVRMRD-EQIRELNQQLDE--VTTQLNVQ 626
Cdd:COG3206    93 RPVLERVVDKLNLdedplgeeASREAAIERLRKNLTVEPVKGSN---VIEISYTSPDpELAAAVANALAEayLEQNLELR 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  627 KADSSALDDMLRLQKEGTEEKstlLEKTEKELV--QSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQI- 703
Cdd:COG3206   170 REEARKALEFLEEQLPELRKE---LEEAEAALEefRQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALr 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  704 -QLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLG--------HEKLQ 774
Cdd:COG3206   247 aQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRilasleaeLEALQ 326

                         250       260       270
                  ....*....|....*....|....*....|.
gi 442628156  775 AALEELKKEKETI------IKEKEQELQQLQ 799
Cdd:COG3206   327 AREASLQAQLAQLearlaeLPELEAELRRLE 357
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1136-1309 2.66e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.45  E-value: 2.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1136 EADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEiqqsLQELQDSVKQKE 1215
Cdd:COG1579    14 ELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKK----YEEQLGNVRNNK 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1216 ELvQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQvqeangDIKDSL 1295
Cdd:COG1579    90 EY-EALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEA------ELEELE 162

                         170
                  ....*....|....
gi 442628156 1296 VKVEELVKVLEEKL 1309
Cdd:COG1579   163 AEREELAAKIPPEL 176
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 602-806 2.76e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 42.22  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  602 VRMRDEQIRELNQQLDEVTTQLnvQKADSSALDDMLR-LQKEGTEEKSTLLEKTEKELVQ-----SKEQAAKTLN---DK 672
Cdd:PRK05771    4 VRMKKVLIVTLKSYKDEVLEAL--HELGVVHIEDLKEeLSNERLRKLRSLLTKLSEALDKlrsylPKLNPLREEKkkvSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  673 EQLEKQISDLKQLAEQ-EKLVREMTENaINQIQLEKESIEQQLA--------------LKQNEL----------EDFQKK 727
Cdd:PRK05771   82 KSLEELIKDVEEELEKiEKEIKELEEE-ISELENEIKELEQEIErlepwgnfdldlslLLGFKYvsvfvgtvpeDKLEEL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  728 QSESEVHLQEIKAQNTQKDFELV--------ESGESLKKLQQQlEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQ 799
Cdd:PRK05771  161 KLESDVENVEYISTDKGYVYVVVvvlkelsdEVEEELKKLGFE-RLELEEEGTPSELIREIKEELEEIEKERESLLEELK 239


                  ....*..
gi 442628156  800 SKSAESE 806
Cdd:PRK05771  240 ELAKKYL 246
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 387-715 3.08e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 42.22  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  387 KARIVelesALDNERKKT-EELQcSIDEAQFCgdELNAQSQVykEKIHDLESKITKLVSATPSLQSILPPDlpsddGALQ 465
Cdd:PRK05771    8 KVLIV----TLKSYKDEVlEALH-ELGVVHIE--DLKEELSN--ERLRKLRSLLTKLSEALDKLRSYLPKL-----NPLR 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  466 EEIAKLQEKMTIQQKEVESRIAEQLEEEqrlrenVKYLNEQIATLQSELvskdEALEKfslsecgienlrrelellkeen 545
Cdd:PRK05771   74 EEKKKVSVKSLEELIKDVEEELEKIEKE------IKELEEEISELENEI----KELEQ---------------------- 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  546 ekqaqeaqaeftrklAEKSVEVLR-LSSELQNLKATSD-SLESERVNKTDECEILQTEVrmrDEQIRELNQQLDEVTTQL 623
Cdd:PRK05771  122 ---------------EIERLEPWGnFDLDLSLLLGFKYvSVFVGTVPEDKLEELKLESD---VENVEYISTDKGYVYVVV 183

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  624 NVQKADSSALDDMLRlqKEGTEEKSTLLEKTEKELVQSKEQAAKTLND-KEQLEKQISDLKQLAEQEKLVREmtenAINQ 702
Cdd:PRK05771  184 VVLKELSDEVEEELK--KLGFERLELEEEGTPSELIREIKEELEEIEKeRESLLEELKELAKKYLEELLALY----EYLE 257

                         330
                  ....*....|...
gi 442628156  703 IQLEKESIEQQLA 715
Cdd:PRK05771  258 IELERAEALSKFL 270
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 702-1033 3.24e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 42.19  E-value: 3.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   702 QIQLEKESIEQQLALKQNEL--EDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEE 779
Cdd:pfam07888   33 QNRLEECLQERAELLQAQEAanRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEE 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   780 LKKEKETIIKEKEQELQQLQsksaESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEisqlKSQAEETQSELKSTQ 859
Cdd:pfam07888  113 LSEEKDALLAQRAAHEARIR----ELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEE----EAERKQLQAKLQQTE 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   860 SNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQ---AALSSCHTDVESKTKQLEAANAALEKVNKEYAEsr 936
Cdd:pfam07888  185 EELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHrkeAENEALLEELRSLQERLNASERKVEGLGEELSS-- 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   937 aeasdlqdkVKEITDTLHAELQAERSSSSALHTKLSKFSDeiatghkeltskadAWSQEMLQKEKELQELRQQLQDSQDS 1016
Cdd:pfam07888  263 ---------MAAQRDRTQAELHQARLQAAQLTLQLADASL--------------ALREGRARWAQERETLQQSAEADKDR 319

                          330
                   ....*....|....*..
gi 442628156  1017 QTKLKAEGERKEKSFEE 1033
Cdd:pfam07888  320 IEKLSAELQRLEERLQE 336
AAA_13 pfam13166
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 560-955 3.96e-03

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease.


Pssm-ID: 463796 [Multi-domain]  Cd Length: 712  Bit Score: 41.97  E-value: 3.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   560 LAEKSVEVLRLSselqnlkatsDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSsalddMLRL 639
Cdd:pfam13166   87 LGEESIEIQEKI----------AKLKKEIKDHEEKLDAAEANLQKLDKEKEKLEADFLDECWKKIKRKKNS-----ALSE 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   640 QKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDkeqlEKQISDLKQLAEQEK-LVREMTENAINQIQLEKESI-EQQLALK 717
Cdd:pfam13166  152 ALNGFKYEANFKSRLLREIEKDNFNAGVLLSD----EDRKAALATVFSDNKpEIAPLTFNVIDFDALEKAEIlIQKVIGK 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   718 QNELEDFQKKQSESEvhlqeikaqntqkdfeLVESGESL-KKLQQQLE--QKTLGHEkLQAALEE------------LKK 782
Cdd:pfam13166  228 SSAIEELIKNPDLAD----------------WVEQGLELhKAHLDTCPfcGQPLPAE-RKAALEAhfddeftefqnrLQK 290

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   783 EKETIIKEKEQELQQLQSKSAESesalkvvqvqleqlqqqaaasgeegsKTVAKLHDEISQLKSQAEETQSELKSTQSNL 862
Cdd:pfam13166  291 LIEKVESAISSLLAQLPAVSDLA--------------------------SLLSAFELDVEDIESEAEVLNSQLDGLRRAL 344

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   863 EAKSKQ-------------LEAANGS-----------------LEEEAKKSGHLLEQ--ITKLKSEVGETQAALSSCHTD 910
Cdd:pfam13166  345 EAKRKDpfksieldsvdakIESINDLvasineliakhneitdnFEEEKNKAKKKLRLhlVEEFKSEIDEYKDKYAGLEKA 424

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*
gi 442628156   911 VESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHA 955
Cdd:pfam13166  425 INSLEKEIKNLEAEIKKLREEIKELEAQLRDHKPGADEINKLLKA 469
COG5391 COG5391
Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function ...
 1128-1283 4.40e-03

Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function prediction only];


Pssm-ID: 227680 [Multi-domain]  Cd Length: 524  Bit Score: 41.71  E-value: 4.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1128 HIFELFEMEAdMNSERLIEKVTGIKEELKETHLQ-LDERQ---KKFEELEEKLkqAQQSEQKLQQESQTSKEKLTEIQ-- 1201
Cdd:COG5391   301 SIFSLFEKIL-IQLESEEESLTRLLESLNNLLLLvLNFSGvfaKRLEQNQNSI--LNEGVVQAETLRSSLKELLTQLQde 377

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1202 -QSLQELQDSVKQKEELVQNLEEKVRESSSIiEAQNTKLNESNV-QLENKTSCLKETQD-----QLLESQKKEKQLQEEA 1274
Cdd:COG5391   378 iKSRESLILTDSNLEKLTDQNLEDVEELSRS-LRKNSSQRAVVSqQPEGLTSFSKLSYKlrdfvQEKSRSKSIESLQQDK 456


                  ....*....
gi 442628156 1275 AKLSGELQQ 1283
Cdd:COG5391   457 EKLEEQLAI 465
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 832-973 4.44e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.68  E-value: 4.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  832 KTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHL--LEQITKLKSEVGETQAALSSCHT 909
Cdd:COG1579    31 AELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVrnNKEYEALQKEIESLKRRISDLED 110

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442628156  910 DVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSK 973
Cdd:COG1579   111 EILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAKIPP 174
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1325-1439 4.58e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 41.74  E-value: 4.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1325 ELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDES-NTVLESQKKSHNEIQDKLEQA 1403
Cdd:PRK00409  517 KLNELIASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAEKEaQQAIKEAKKEADEIIKELRQL 596

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 442628156 1404 QQKERTLQEEtSKLAEQLSQLKQANEELQKSLQQKQ 1439
Cdd:PRK00409  597 QKGGYASVKA-HELIEARKRLNKANEKKEKKKKKQK 631
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1021-1219 4.69e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 41.54  E-value: 4.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1021 KAEGERKEKSFEESIKNLQEEVTKA-------KTENLELSTGTQTT-----IKDLQERLEITNAELQHKEKMASEDAQKI 1088
Cdd:COG3206   170 REEARKALEFLEEQLPELRKELEEAeaaleefRQKNGLVDLSEEAKlllqqLSELESQLAEARAELAEAEARLAALRAQL 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1089 ADLKTLVEAIQvANANISATNAELSTvLEVLQAEKSET---NH--IFELFEMEADMNS---ERLIEKVTGIKEELKETHL 1160
Cdd:COG3206   250 GSGPDALPELL-QSPVIQQLRAQLAE-LEAELAELSARytpNHpdVIALRAQIAALRAqlqQEAQRILASLEAELEALQA 327

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442628156 1161 QLDERQKKFEELEEKLKQAQQSEQK---LQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQ 1219
Cdd:COG3206   328 REASLQAQLAQLEARLAELPELEAElrrLEREVEVARELYESLLQRLEEARLAEALTVGNVR 389
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 1259-1438 5.19e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 39.89  E-value: 5.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1259 QLLESQKKE-KQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQaatsQLDAQQATNKELQELLVKSQENE 1337
Cdd:pfam13851   26 ELIKSLKEEiAELKKKEERNEKLMSEIQQENKRLTEPLQKAQEEVEELRKQLE----NYEKDKQSLKNLKARLKVLEKEL 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1338 GNLQGESLAVTEKLQQLEQANGELKEalcQKENGLKELQGKLDESNTVLESQkkshneIQDKLEQAQQKERTLQEETSKL 1417
Cdd:pfam13851  102 KDLKWEHEVLEQRFEKVERERDELYD---KFEAAIQDVQQKTGLKNLLLEKK------LQALGETLEKKEAQLNEVLAAA 172

                          170       180
                   ....*....|....*....|.
gi 442628156  1418 AEQLSQLKQANEELQKSLQQK 1438
Cdd:pfam13851  173 NLDPDALQAVTEKLEDVLESK 193
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 372-648 5.31e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.29  E-value: 5.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  372 AQNQALQLQKNINELKARIVELESALDNERKKTEELQcsideaqfcgdelnaqsqvykEKIHDLESKItklvsatpslqs 451
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALL---------------------KQLAALERRI------------ 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  452 ilppdlpsddGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQselVSKDEALEKFSLSecgi 531
Cdd:COG4942    65 ----------AALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALY---RLGRQPPLALLLS---- 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  532 eNLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDEceiLQTEVRMRDEQIRE 611
Cdd:COG4942   128 -PEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAA---LEALKAERQKLLAR 203

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 442628156  612 LNQQLDEVTTQLNVQKADSSALDDML-RLQKEGTEEKS 648
Cdd:COG4942   204 LEKELAELAAELAELQQEAEELEALIaRLEAEAAAAAE 241
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 1146-1393 5.54e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 41.57  E-value: 5.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1146 EKVTGIKEELKETHLQLDERQKK------FEELEEKLKQAQQSEQKLQQESQTSkEKLTEIQQSLQELQDSVKQKEELVQ 1219
Cdd:PTZ00108 1102 EKVEKLNAELEKKEKELEKLKNTtpkdmwLEDLDKFEEALEEQEEVEEKEIAKE-QRLKSKTKGKASKLRKPKLKKKEKK 1180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1220 NLEEKVRESSSIIEAQNTKLNESNVQLE-----NKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDS 1294
Cdd:PTZ00108 1181 KKKSSADKSKKASVVGNSKRVDSDEKRKlddkpDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEF 1260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1295 LVKVEELVKVLEEKLQAATSQLDAQQATNKEL-QELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLK 1373
Cdd:PTZ00108 1261 SSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPdGESNGGSKPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKTR 1340

                         250       260
                  ....*....|....*....|
gi 442628156 1374 ELQGKlDESNTVLESQKKSH 1393
Cdd:PTZ00108 1341 VKQAS-ASQSSRLLRRPRKK 1359
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 872-1111 5.60e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.97  E-value: 5.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  872 ANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITd 951
Cdd:COG3883    14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERA- 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  952 tlhAELQAERSSSSALHTKLSkfsdeiATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSf 1031
Cdd:COG3883    93 ---RALYRSGGSVSYLDVLLG------SESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEAL- 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1032 EESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAE 1111
Cdd:COG3883   163 KAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 242
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
650-904 5.61e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.04  E-value: 5.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  650 LLEKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQS 729
Cdd:COG4372    18 LRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  730 ESEVHLQEIKAQNTQKDFELvesgESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESAL 809
Cdd:COG4372    98 QAQEELESLQEEAEELQEEL----EELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQEL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  810 KVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQ 889
Cdd:COG4372   174 QALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLE 253

                         250
                  ....*....|....*
gi 442628156  890 ITKLKSEVGETQAAL 904
Cdd:COG4372   254 EVILKEIEELELAIL 268
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
365-584 6.00e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 41.16  E-value: 6.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  365 RDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQcsideaqfcgdeLNAQSQVYKEKIHDLESKITKLVS 444
Cdd:COG3206   166 LELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNGLVD------------LSEEAKLLLQQLSELESQLAEARA 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  445 ATPSLQSILpPDLPSDDGALQEEIAKLQEKMTIQQ-----KEVESRIAEQLeeeQRLREN---VKYLNEQIATLQSELvs 516
Cdd:COG3206   234 ELAEAEARL-AALRAQLGSGPDALPELLQSPVIQQlraqlAELEAELAELS---ARYTPNhpdVIALRAQIAALRAQL-- 307

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442628156  517 KDEALEKFSlsecGIENLRRELELLKEENEKQAQEAQAEFtRKLAEKSVEVLRLSSELQNLKATSDSL 584
Cdd:COG3206   308 QQEAQRILA----SLEAELEALQAREASLQAQLAQLEARL-AELPELEAELRRLEREVEVARELYESL 370
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 1170-1444 6.05e-03

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 41.28  E-value: 6.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1170 EELEEKLKQAQQSEqkLQQESQTSKEKLTEIQQSLQELQDSVKQK----EELVQNLEEK-VRESSSIIEAQN------TK 1238
Cdd:pfam07111  128 EMVRKNLEEGSQRE--LEEIQRLHQEQLSSLTQAHEEALSSLTSKaeglEKSLNSLETKrAGEAKQLAEAQKeaellrKQ 205

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1239 LNESNVQLENKTSCLKETQDQLLESQKKEKQLQE---EAAKLSGELQQVQEANGDIKDSL----VKVEELVKVL---EEK 1308
Cdd:pfam07111  206 LSKTQEELEAQVTLVESLRKYVGEQVPPEVHSQTwelERQELLDTMQHLQEDRADLQATVellqVRVQSLTHMLalqEEE 285

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  1309 LQAATSQLDAQQAT-NKELQELLVKSQEN----EGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESN 1383
Cdd:pfam07111  286 LTRKIQPSDSLEPEfPKKCRSLLNRWREKvfalMVQLKAQDLEHRDSVKQLRGQVAELQEQVTSQSQEQAILQRALQDKA 365

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442628156  1384 TVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEK 1444
Cdd:pfam07111  366 AEVEVERMSAKGLQMELSRAQEARRRQQQQTASAEEQLKFVVNAMSSTQIWLETTMTRVEQ 426
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 377-801 6.31e-03

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 41.21  E-value: 6.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   377 LQLQKNINELKARIVELESALDNERKKTEELQcsideaqfcgdelnaqsqvykEKIHDLESKITKLVSATPSLQsilppd 456
Cdd:pfam05622   62 LLLQKQLEQLQEENFRLETARDDYRIKCEELE---------------------KEVLELQHRNEELTSLAEEAQ------ 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   457 lpsddgALQEEIAKLQE---KMTIQQKEVESrIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIEN 533
Cdd:pfam05622  115 ------ALKDEMDILREssdKVKKLEATVET-YKKKLEDLGDLRRQVKLLEERNAEYMQRTLQLEEELKKANALRGQLET 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   534 lrrelellkeeNEKQAQEAQAeftrKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILqtevRMRDEQIRELN 613
Cdd:pfam05622  188 -----------YKRQVQELHG----KLSEESKKADKLEFEYKKLEEKLEALQKEKERLIIERDTL----RETNEELRCAQ 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   614 QQLDEVTTQLNVQKADSSALDDMLR-LQKEGTEEKSTLLEKTEKELvqskeqaakTLNDKEQLEKQISDLKQLAEQeklv 692
Cdd:pfam05622  249 LQQAELSQADALLSPSSDPGDNLAAeIMPAEIREKLIRLQHENKML---------RLGQEGSYRERLTELQQLLED---- 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   693 remTENAINQIQLEKESIEQQLALKQNELEDFQKKQSEsevhlQEIKAQNT-QKDFELVESGESLKKLQQQLEQKTLGHE 771
Cdd:pfam05622  316 ---ANRRKNELETQNRLANQRILELQQQVEELQKALQE-----QGSKAEDSsLLKQKLEEHLEKLHEAQSELQKKKEQIE 387

                          410       420       430
                   ....*....|....*....|....*....|....
gi 442628156   772 KLQAALEELKKEK----ETIIKEKEQELQQLQSK 801
Cdd:pfam05622  388 ELEPKQDSNLAQKidelQEALRKKDEDMKAMEER 421
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 343-796 6.75e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 41.25  E-value: 6.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   343 SQFSMQDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQCSIDEAQFCGDELN 422
Cdd:pfam05483  209 ARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELI 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   423 AQSQVYKEKIHDLESKITKLVSATPSLQSILPP------DLPSDDGALQEEIAKLQEKMTIQQKEVESRIAEQLE----E 492
Cdd:pfam05483  289 EKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIatkticQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEEllrtE 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   493 EQRLRENvkylNEQIATLQSELVSKDEALEKFSlsecGIENLRRELELLKEENEKQAQeaqaeftrKLAEKSVEVLRLSS 572
Cdd:pfam05483  369 QQRLEKN----EDQLKIITMELQKKSSELEEMT----KFKNNKEVELEELKKILAEDE--------KLLDEKKQFEKIAE 432

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   573 ELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQireLNQQLDEVTTQLNVQKADSSALD---DMLRLQ-KEGTEEKS 648
Cdd:pfam05483  433 ELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEH---YLKEVEDLKTELEKEKLKNIELTahcDKLLLEnKELTQEAS 509

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   649 TL---LEKTEKELVQSKEQAAKTL-----------NDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQL 714
Cdd:pfam05483  510 DMtleLKKHQEDIINCKKQEERMLkqienleekemNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQM 589

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156   715 ALKQNELEDFQKKQSESEVHLQEIKAQNtqKDFELVESGESlkklqQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQE 794
Cdd:pfam05483  590 KILENKCNNLKKQIENKNKNIEELHQEN--KALKKKGSAEN-----KQLNAYEIKVNKLELELASAKQKFEEIIDNYQKE 662


                   ..
gi 442628156   795 LQ 796
Cdd:pfam05483  663 IE 664
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 559-769 6.95e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.58  E-value: 6.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  559 KLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKAdssALDDMLR 638
Cdd:COG3883    17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERRE---ELGERAR 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  639 -LQKEGTEEK--STLLEKTEKELVQSKEQAAKTL--NDKEQLEKQISDLKQLAEQEKLVRE---MTENAINQIQLEKESI 710
Cdd:COG3883    94 aLYRSGGSVSylDVLLGSESFSDFLDRLSALSKIadADADLLEELKADKAELEAKKAELEAklaELEALKAELEAAKAEL 173

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 442628156  711 EQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLG 769
Cdd:COG3883   174 EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAA 232
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 889-1067 8.72e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 39.91  E-value: 8.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  889 QITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHA-----ELQAerss 963
Cdd:COG1579    18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNvrnnkEYEA---- 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  964 ssalhtklskFSDEIATGHKELTSKADawsqEMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVT 1043
Cdd:COG1579    94 ----------LQKEIESLKRRISDLED----EILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELE 159

                         170       180
                  ....*....|....*....|....
gi 442628156 1044 KAKTENLELSTGTQTTIKDLQERL 1067
Cdd:COG1579   160 ELEAEREELAAKIPPELLALYERI 183
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 771-1258 9.54e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 40.81  E-value: 9.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  771 EKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLqqqaaasgEEGSKTVAKLHDEISQLKS---Q 847
Cdd:PRK10929   26 KQITQELEQAKAAKTPAQAEIVEALQSALNWLEERKGSLERAKQYQQVI--------DNFPKLSAELRQQLNNERDeprS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  848 AEETQSELKSTQSNLEAKSKQLEAANgSLEEEAKKSGHLLEQITKLKSEVGETQAALSschtDVESKTKQLEAANAALEK 927
Cdd:PRK10929   98 VPPNMSTDALEQEILQVSSQLLEKSR-QAQQEQDRAREISDSLSQLPQQQTEARRQLN----EIERRLQTLGTPNTPLAQ 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156  928 VnkEYAESRAEASDLQDKVKEItdtlhaELqAERSSSSalhtklskfSDEIATGHKELTSKADAwsqemlQKEKELQELR 1007
Cdd:PRK10929  173 A--QLTALQAESAALKALVDEL------EL-AQLSANN---------RQELARLRSELAKKRSQ------QLDAYLQALR 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1008 QQLQDSQDSQTKLKAEgeRKEKsFEESIKNLQEEVTKAKTENLELSTgtqttikdlqerleITNAELQHKEKMASEdaQK 1087
Cdd:PRK10929  229 NQLNSQRQREAERALE--STEL-LAEQSGDLPKSIVAQFKINRELSQ--------------ALNQQAQRMDLIASQ--QR 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1088 IADLKTLveaiQVANAnisatnaeLSTVLEVLQAEKSETnhifelfemeadMNSERLIEKVTGIKEELKETHL-----QL 1162
Cdd:PRK10929  290 QAASQTL----QVRQA--------LNTLREQSQWLGVSN------------ALGEALRAQVARLPEMPKPQQLdtemaQL 345

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628156 1163 DERQKKFEELEEKLkqaqqseQKLQQESQTSKEKLTEIQQSLqeLQDSVKQKEELVQNLEEKVreSSSIIEAqnTKLNES 1242
Cdd:PRK10929  346 RVQRLRYEDLLNKQ-------PQLRQIRQADGQPLTAEQNRI--LDAQLRTQRELLNSLLSGG--DTLILEL--TKLKVA 412

                         490
                  ....*....|....*.
gi 442628156 1243 NVQLENktsCLKETQD 1258
Cdd:PRK10929  413 NSQLED---ALKEVNE 425
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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