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Conserved domains on  [gi|442627318|ref|NP_001162939|]
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lonely heart, isoform D [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 349-468 2.70e-29

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 112.67  E-value: 2.70e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627318  349 PVTGIFTRNPlpEHAYIHVTTLPVGASNISITELKNSINLLVLRTSNELAIFNGENTVS-ESGSYEAVGAVFDYHRidga 427
Cdd:pfam05986   1 TVSGSFTEGR--AKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRR---- 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 442627318  428 edSNGVTEWITSIGPIRDSLQLMVFTKS--ANNTGVKYEYMLP 468
Cdd:pfam05986  75 --SLPALEELHAPGPTQEDLEIQVLRQYgkGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 664-715 6.44e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.54  E-value: 6.44e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 442627318  664 WLVSDWNQyCSVTCGSGVEYRTVFC----DRSKAGEQRCDPSTTPESRRPCEKPAC 715
Cdd:pfam19030   1 WVAGPWGE-CSVTCGGGVQTRLVQCvqkgGGSIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 846-876 8.28e-10

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


:

Pssm-ID: 462560  Cd Length: 31  Bit Score: 54.46  E-value: 8.28e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 442627318  846 CADKFSNCQWASQAKLCSYDYYRDNCCFSCT 876
Cdd:pfam08686   1 CKDKFANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 779-835 9.25e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.15  E-value: 9.25e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 442627318  779 WHYSDWSECTKPCGGGTQRRSVRCLEYDikMNALRESTHCRYTNREPIYRNCNVQAC 835
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKG--GGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 182-238 6.64e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 52.59  E-value: 6.64e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 442627318   182 WDKWSDWSSCSRSCGGGVKYQVRKCINRnlltNNQLTSNACVGYFKRYQLCNDVPCD 238
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSP----PPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 510-567 1.14e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.99  E-value: 1.14e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 442627318  510 WKVIGFSSCTKSCGGGTQTPIIRCIRKNPLRYYSQRRCTHSVKPVLNEnllHCNTQPC 567
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQ---SCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 720-768 9.15e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 46.68  E-value: 9.15e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 442627318  720 WFTGPWSSCNGDCFDLTRTREVLCIR--SQLITEHSECTPELKPQSVEKCS 768
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQkgGGSIVPDSECSAQKKPPETQSCN 51
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 349-468 2.70e-29

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 112.67  E-value: 2.70e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627318  349 PVTGIFTRNPlpEHAYIHVTTLPVGASNISITELKNSINLLVLRTSNELAIFNGENTVS-ESGSYEAVGAVFDYHRidga 427
Cdd:pfam05986   1 TVSGSFTEGR--AKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRR---- 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 442627318  428 edSNGVTEWITSIGPIRDSLQLMVFTKS--ANNTGVKYEYMLP 468
Cdd:pfam05986  75 --SLPALEELHAPGPTQEDLEIQVLRQYgkGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 664-715 6.44e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.54  E-value: 6.44e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 442627318  664 WLVSDWNQyCSVTCGSGVEYRTVFC----DRSKAGEQRCDPSTTPESRRPCEKPAC 715
Cdd:pfam19030   1 WVAGPWGE-CSVTCGGGVQTRLVQCvqkgGGSIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 846-876 8.28e-10

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 54.46  E-value: 8.28e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 442627318  846 CADKFSNCQWASQAKLCSYDYYRDNCCFSCT 876
Cdd:pfam08686   1 CKDKFANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 779-835 9.25e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.15  E-value: 9.25e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 442627318  779 WHYSDWSECTKPCGGGTQRRSVRCLEYDikMNALRESTHCRYTNREPIYRNCNVQAC 835
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKG--GGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 182-238 6.64e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 52.59  E-value: 6.64e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 442627318   182 WDKWSDWSSCSRSCGGGVKYQVRKCINRnlltNNQLTSNACVGYFKRYQLCNDVPCD 238
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSP----PPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 510-567 1.14e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.99  E-value: 1.14e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 442627318  510 WKVIGFSSCTKSCGGGTQTPIIRCIRKNPLRYYSQRRCTHSVKPVLNEnllHCNTQPC 567
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQ---SCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 720-768 9.15e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 46.68  E-value: 9.15e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 442627318  720 WFTGPWSSCNGDCFDLTRTREVLCIR--SQLITEHSECTPELKPQSVEKCS 768
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQkgGGSIVPDSECSAQKKPPETQSCN 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 779-835 2.18e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 45.27  E-value: 2.18e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 442627318   779 WHYSDWSECTKPCGGGTQRRSVRCleydIKMNALRESTHCRYTNREpiYRNCNVQAC 835
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSC----CSPPPQNGGGPCTGEDVE--TRACNEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 185-205 3.65e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 39.18  E-value: 3.65e-04
                          10        20
                  ....*....|....*....|.
gi 442627318  185 WSDWSSCSRSCGGGVKYQVRK 205
Cdd:pfam19028   6 WSEWSECSVTCGGGVQTRTRT 26
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 667-716 1.09e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.95  E-value: 1.09e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 442627318   667 SDWNQyCSVTCGSGVEYRTVFCDR--SKAGEQRCDPSTTpeSRRPCEKPACE 716
Cdd:smart00209   5 SEWSP-CSVTCGGGVQTRTRSCCSppPQNGGGPCTGEDV--ETRACNEQPCP 53
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 349-468 2.70e-29

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 112.67  E-value: 2.70e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627318  349 PVTGIFTRNPlpEHAYIHVTTLPVGASNISITELKNSINLLVLRTSNELAIFNGENTVS-ESGSYEAVGAVFDYHRidga 427
Cdd:pfam05986   1 TVSGSFTEGR--AKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRR---- 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 442627318  428 edSNGVTEWITSIGPIRDSLQLMVFTKS--ANNTGVKYEYMLP 468
Cdd:pfam05986  75 --SLPALEELHAPGPTQEDLEIQVLRQYgkGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 664-715 6.44e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.54  E-value: 6.44e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 442627318  664 WLVSDWNQyCSVTCGSGVEYRTVFC----DRSKAGEQRCDPSTTPESRRPCEKPAC 715
Cdd:pfam19030   1 WVAGPWGE-CSVTCGGGVQTRLVQCvqkgGGSIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 846-876 8.28e-10

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 54.46  E-value: 8.28e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 442627318  846 CADKFSNCQWASQAKLCSYDYYRDNCCFSCT 876
Cdd:pfam08686   1 CKDKFANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 779-835 9.25e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.15  E-value: 9.25e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 442627318  779 WHYSDWSECTKPCGGGTQRRSVRCLEYDikMNALRESTHCRYTNREPIYRNCNVQAC 835
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKG--GGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 182-238 6.64e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 52.59  E-value: 6.64e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 442627318   182 WDKWSDWSSCSRSCGGGVKYQVRKCINRnlltNNQLTSNACVGYFKRYQLCNDVPCD 238
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSP----PPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 510-567 1.14e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.99  E-value: 1.14e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 442627318  510 WKVIGFSSCTKSCGGGTQTPIIRCIRKNPLRYYSQRRCTHSVKPVLNEnllHCNTQPC 567
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQ---SCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 720-768 9.15e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 46.68  E-value: 9.15e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 442627318  720 WFTGPWSSCNGDCFDLTRTREVLCIR--SQLITEHSECTPELKPQSVEKCS 768
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQkgGGSIVPDSECSAQKKPPETQSCN 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 779-835 2.18e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 45.27  E-value: 2.18e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 442627318   779 WHYSDWSECTKPCGGGTQRRSVRCleydIKMNALRESTHCRYTNREpiYRNCNVQAC 835
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSC----CSPPPQNGGGPCTGEDVE--TRACNEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 185-205 3.65e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 39.18  E-value: 3.65e-04
                          10        20
                  ....*....|....*....|.
gi 442627318  185 WSDWSSCSRSCGGGVKYQVRK 205
Cdd:pfam19028   6 WSEWSECSVTCGGGVQTRTRT 26
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 667-716 1.09e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.95  E-value: 1.09e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 442627318   667 SDWNQyCSVTCGSGVEYRTVFCDR--SKAGEQRCDPSTTpeSRRPCEKPACE 716
Cdd:smart00209   5 SEWSP-CSVTCGGGVQTRTRSCCSppPQNGGGPCTGEDV--ETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 187-237 1.33e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 37.43  E-value: 1.33e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 442627318  187 DWSSCSRSCGGGVKYQVRKCINRNlltNNQLTSNACVGYFKRY---QLCNDVPC 237
Cdd:pfam19030   5 PWGECSVTCGGGVQTRLVQCVQKG---GGSIVPDSECSAQKKPpetQSCNLKPC 55
TSP_1 pfam00090
Thrombospondin type 1 domain;
185-237 1.83e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 37.01  E-value: 1.83e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 442627318  185 WSDWSSCSRSCGGGVKYQVRKCinrnllTNNQLTSNACVGYFKRYQLCNDVPC 237
Cdd:pfam00090   3 WSPWSPCSVTCGKGIQVRQRTC------KSPFPGGEPCTGDDIETQACKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 782-799 8.21e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 35.33  E-value: 8.21e-03
                          10
                  ....*....|....*...
gi 442627318  782 SDWSECTKPCGGGTQRRS 799
Cdd:pfam19028   7 SEWSECSVTCGGGVQTRT 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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