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Conserved domains on  [gi|665389571|ref|NP_001162664|]
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ruby, isoform D [Drosophila melanogaster]

Protein Classification

AP-3 complex subunit beta( domain architecture ID 12024697)

AP-3 complex subunit beta is part of the non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
40-621 2.03e-167

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


:

Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 505.23  E-value: 2.03e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571    40 SDGRKHDDLKQMLDSNKDG--LKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQDLALLS 117
Cdd:pfam01602    1 EEKRIQQELARILNSFRDDprKKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLAILV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   118 ISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLYSLDADQKDELVMVIEKLL 197
Cdd:pfam01602   81 TNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDFVPELKELL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   198 SDRTTLVVGSAVMAFDEVC---PERVDLIHKNYRKLCNFLLDVDEWGQVIIINMLTRYARTQFVDPnaddedlvndglge 274
Cdd:pfam01602  161 SDKDPGVQSAAVALLYEICkndRLYLKLLPLLFRRLCNLLGVLNPWLQVKILRLLTRLAPLDPLLP-------------- 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   275 tpvserfydesshssshsddgssddeknksstnnknngggngsrtpsspsnsyhidvdhRLLLRQTKPLLQSRNASVVMA 354
Cdd:pfam01602  227 -----------------------------------------------------------KELLEDLLNLLQNSNNAVLYE 247
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   355 VAQLYHHVAPKNE-VQLIAKALIRLLRSHKE-VQSVVLNCIASMSTKR-KAIFEPHLKSFFVRTSDPTHIKLLKLDILTN 431
Cdd:pfam01602  248 TANTIVHLAPAPElIVLAVNALGRLLSSPDEnLRYVALRNLNKIVMKEpKAVQHLDLIIFCLKTDDDISIRLRALDLLYA 327
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   432 LASAGSISLILREFQTYISS-SDRSFVAATIQAIGRCASSIKEVTETCLSGLVHLLSNHDEHVVAESVVVIKRLLQTKAA 510
Cdd:pfam01602  328 LVNESNVKEIVKELLKYVHEiADPDFKIELVRAIGRLAEKFPTDAEWYLDVLLDLLSLAGSYVVDEIVEVIRDIIQNVPE 407
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   511 EHFEIITQMAKLIDYINVPAARAAIIWLIGEYNEKVP--LIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNPEQT- 587
Cdd:pfam01602  408 LREYILEHLCELLEDIESPEALAAALWILGEYGELIPngSSPPDLLRSILEVFVLESAKVRAAALTALAKLGLTSPEETt 487
                          570       580       590
                   ....*....|....*....|....*....|....*.
gi 665389571   588 -SLLCQYVFTLARYD-PNYDVRDRARFLRQIIFPAS 621
Cdd:pfam01602  488 qNLIIQLLLTLATQDsLDLEVRDRAVEYLRLLSLAD 523
AP3B1_C pfam14796
Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of ...
881-1019 2.54e-61

Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of the clathrin-adaptor protein complex-3 beta-1 subunit. The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules.


:

Pssm-ID: 464319  Cd Length: 148  Bit Score: 205.96  E-value: 2.54e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   881 IPPIGPVMTPSLGGFLTPGTPMMAGQAAPLQpqhARNRVELVGPSHIEFKHKELLNKVSGHGLHLAYRFTRSPHLYSSSM 960
Cdd:pfam14796   13 FSPSSPVMTPSLGGFLSPSLATDLEGLSLTD---SSSAIEVVSPSFVPTKTHELLHRMTGEGLSVEYRFTRQPCIYSPKM 89
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 665389571   961 CSIELQFQNRGEKEITAIRLGQTTLPAGMQLNEFAPITVLQPQQTASGVLGVDFNDSTH 1019
Cdd:pfam14796   90 VSVELTFTNTSDSEITNIHIGEKKLPAGMRIHEFAEIESLEPGASATVVMGIDFCDSTQ 148
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
40-621 2.03e-167

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 505.23  E-value: 2.03e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571    40 SDGRKHDDLKQMLDSNKDG--LKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQDLALLS 117
Cdd:pfam01602    1 EEKRIQQELARILNSFRDDprKKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLAILV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   118 ISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLYSLDADQKDELVMVIEKLL 197
Cdd:pfam01602   81 TNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDFVPELKELL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   198 SDRTTLVVGSAVMAFDEVC---PERVDLIHKNYRKLCNFLLDVDEWGQVIIINMLTRYARTQFVDPnaddedlvndglge 274
Cdd:pfam01602  161 SDKDPGVQSAAVALLYEICkndRLYLKLLPLLFRRLCNLLGVLNPWLQVKILRLLTRLAPLDPLLP-------------- 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   275 tpvserfydesshssshsddgssddeknksstnnknngggngsrtpsspsnsyhidvdhRLLLRQTKPLLQSRNASVVMA 354
Cdd:pfam01602  227 -----------------------------------------------------------KELLEDLLNLLQNSNNAVLYE 247
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   355 VAQLYHHVAPKNE-VQLIAKALIRLLRSHKE-VQSVVLNCIASMSTKR-KAIFEPHLKSFFVRTSDPTHIKLLKLDILTN 431
Cdd:pfam01602  248 TANTIVHLAPAPElIVLAVNALGRLLSSPDEnLRYVALRNLNKIVMKEpKAVQHLDLIIFCLKTDDDISIRLRALDLLYA 327
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   432 LASAGSISLILREFQTYISS-SDRSFVAATIQAIGRCASSIKEVTETCLSGLVHLLSNHDEHVVAESVVVIKRLLQTKAA 510
Cdd:pfam01602  328 LVNESNVKEIVKELLKYVHEiADPDFKIELVRAIGRLAEKFPTDAEWYLDVLLDLLSLAGSYVVDEIVEVIRDIIQNVPE 407
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   511 EHFEIITQMAKLIDYINVPAARAAIIWLIGEYNEKVP--LIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNPEQT- 587
Cdd:pfam01602  408 LREYILEHLCELLEDIESPEALAAALWILGEYGELIPngSSPPDLLRSILEVFVLESAKVRAAALTALAKLGLTSPEETt 487
                          570       580       590
                   ....*....|....*....|....*....|....*.
gi 665389571   588 -SLLCQYVFTLARYD-PNYDVRDRARFLRQIIFPAS 621
Cdd:pfam01602  488 qNLIIQLLLTLATQDsLDLEVRDRAVEYLRLLSLAD 523
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
52-640 4.43e-65

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 235.78  E-value: 4.43e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   52 LDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQL 131
Cdd:COG5096    28 LESSNDYKKIDAMKKIIAQMSLGEDMSSLFPDVIKNVATRDVELKRLLYLYLERYAKLKPELALLAVNTIQKDLQDPNEE 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  132 IRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLYSLDADQKDELVMVIEK--LLSDRTTLVVGSAV 209
Cdd:COG5096   108 IRGFALRTLSLLRVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYRLDKDLYHELGLIDILkeLVADSDPIVIANAL 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  210 MAFDEVCPER-VDLIHKNYRKLCNF----LLDVDEWGQVIIINMLTRYArtqfvdpnaddedlvndglgetpvserfyde 284
Cdd:COG5096   188 ASLAEIDPELaHGYSLEVILRIPQLdllsLSVSTEWLLLIILEVLTERV------------------------------- 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  285 sshssshsddgssddeknksstnnknngggngsrtPSSPSnsyhidvDHRLLLRQTKPLLQSRNASVVM-AVAQLYHHV- 362
Cdd:COG5096   237 -----------------------------------PTTPD-------SAEDFEERLSPPLQHNNAEVLLiAVKVILRLLv 274
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  363 -APKNEVQLIAKALIRLLRSHKE--VQSVVLNCIASMSTKRKAIFEPHLKSFFVRTSDPTHIKLLKLDILTNLASAGSIS 439
Cdd:COG5096   275 fLPSNNLFLISSPPLVTLLAKPEslIQYVLRRNIQIDLEVCSKLLDKVKKLFLIEYNDDIYIKLEKLDQLTRLADDQNLS 354
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  440 LILREFQTYISSS--DRSFVAATIQAIGRCASSIKEVTETCLSGLVHLLSNHDEHV-----VAESVVVIK---------R 503
Cdd:COG5096   355 QILLELIYYIAENhiDAEMVSEAIKALGDLASKAESSVNDCISELLELLEGVWIRGsyivqEVRIVDCISvirisvlvlR 434
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  504 LLQTKA--------AEHFEIITQMAKLIDYINVpAARAAIIWLIGEYNEKVPLIAPDVLRKMAKSFVDEQDVVKLQVLNL 575
Cdd:COG5096   435 ILPNEYpkillrglYALEETLELQSREPRAKSV-TDKYLGAWLLGEFSDIIPRLEPELLRIAISNFVDETLEVQYTILMS 513
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665389571  576 GVKLYLTNPeqTSLLC---QYVFTLARYDPNY----DVRDRARFLrqiifpASGTSSVLSQHARQVFLASKP 640
Cdd:COG5096   514 SVKLIANSI--RKAKQcnsELDQDVLRRCFDYvlvpDLRDRARMY------SRLLSTPLPEFSDPILCEAKK 577
AP3B1_C pfam14796
Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of ...
881-1019 2.54e-61

Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of the clathrin-adaptor protein complex-3 beta-1 subunit. The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules.


Pssm-ID: 464319  Cd Length: 148  Bit Score: 205.96  E-value: 2.54e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   881 IPPIGPVMTPSLGGFLTPGTPMMAGQAAPLQpqhARNRVELVGPSHIEFKHKELLNKVSGHGLHLAYRFTRSPHLYSSSM 960
Cdd:pfam14796   13 FSPSSPVMTPSLGGFLSPSLATDLEGLSLTD---SSSAIEVVSPSFVPTKTHELLHRMTGEGLSVEYRFTRQPCIYSPKM 89
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 665389571   961 CSIELQFQNRGEKEITAIRLGQTTLPAGMQLNEFAPITVLQPQQTASGVLGVDFNDSTH 1019
Cdd:pfam14796   90 VSVELTFTNTSDSEITNIHIGEKKLPAGMRIHEFAEIESLEPGASATVVMGIDFCDSTQ 148
PTZ00429 PTZ00429
beta-adaptin; Provisional
34-681 2.34e-48

beta-adaptin; Provisional


Pssm-ID: 240415 [Multi-domain]  Cd Length: 746  Bit Score: 185.52  E-value: 2.34e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   34 GAAFFQSDGR-KHDDLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQD 112
Cdd:PTZ00429   22 GSKYFAQTRRgEGAELQNDLNGTDSYRKKAAVKRIIANMTMGRDVSYLFVDVVKLAPSTDLELKKLVYLYVLSTARLQPE 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  113 LALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLYS------LDADQK 186
Cdd:PTZ00429  102 KALLAVNTFLQDTTNSSPVVRALAVRTMMCIRVSSVLEYTLEPLRRAVADPDPYVRKTAAMGLGKLFHddmqlfYQQDFK 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  187 DELVmvieKLLSDRTTLVVGSA---VMAFDEVCPERVDLIHKNYRKLCNFLLDVDEWGQVIIINMLTryartqfvdpnad 263
Cdd:PTZ00429  182 KDLV----ELLNDNNPVVASNAaaiVCEVNDYGSEKIESSNEWVNRLVYHLPECNEWGQLYILELLA------------- 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  264 DEDLVNDGLGETPVSerfydesshssshsddgssddeknksstnnknngggngsrtpsspsnsyhidvdhRLLLRqtkpl 343
Cdd:PTZ00429  245 AQRPSDKESAETLLT-------------------------------------------------------RVLPR----- 264
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  344 LQSRNASVVMAVAQLYHHVAPKNEVQLIAK-------ALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTS 416
Cdd:PTZ00429  265 MSHQNPAVVMGAIKVVANLASRCSQELIERctvrvntALLTLSRRDAETQYIVCKNIHALLVIFPNLLRTNLDSFYVRYS 344
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  417 DPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCLSGLVHLLSNHDE---HV 493
Cdd:PTZ00429  345 DPPFVKLEKLRLLLKLVTPSVAPEILKELAEYASGVDMVFVVEVVRAIASLAIKVDSVAPDCANLLLQIVDRRPEllpQV 424
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  494 VAESVVVIKR-----LLQTKAAEHFEiitqmakliDYINVPAARAAIIWLIGEYNEKVPlIAPDVLRKMAKSFVDEQDVV 568
Cdd:PTZ00429  425 VTAAKDIVRKypellMLDTLVTDYGA---------DEVVEEEAKVSLLWMLGEYCDFIE-NGKDIIQRFIDTIMEHEQRV 494
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  569 KLQVLNLGVKLYLTNP---EQTslLCQYVFTLARYDPNYDVRDRA----RFLRQIIFPASGTSSVLSQHArqvflaskPA 641
Cdd:PTZ00429  495 QLAILSAAVKMFLRDPqgmEPQ--LNRVLETVTTHSDDPDVRDRAfaywRLLSKGITVAQMKKVVHGQMV--------PV 564
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 665389571  642 PVpESKYRDGnnFQLGSLSHYLNMPAAGYKElPAFPVIPP 681
Cdd:PTZ00429  565 NV-DSTFSDA--MTMADLKKSLNTAAIVFAR-PYQSFLPP 600
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
40-621 2.03e-167

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 505.23  E-value: 2.03e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571    40 SDGRKHDDLKQMLDSNKDG--LKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQDLALLS 117
Cdd:pfam01602    1 EEKRIQQELARILNSFRDDprKKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLAILV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   118 ISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLYSLDADQKDELVMVIEKLL 197
Cdd:pfam01602   81 TNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDFVPELKELL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   198 SDRTTLVVGSAVMAFDEVC---PERVDLIHKNYRKLCNFLLDVDEWGQVIIINMLTRYARTQFVDPnaddedlvndglge 274
Cdd:pfam01602  161 SDKDPGVQSAAVALLYEICkndRLYLKLLPLLFRRLCNLLGVLNPWLQVKILRLLTRLAPLDPLLP-------------- 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   275 tpvserfydesshssshsddgssddeknksstnnknngggngsrtpsspsnsyhidvdhRLLLRQTKPLLQSRNASVVMA 354
Cdd:pfam01602  227 -----------------------------------------------------------KELLEDLLNLLQNSNNAVLYE 247
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   355 VAQLYHHVAPKNE-VQLIAKALIRLLRSHKE-VQSVVLNCIASMSTKR-KAIFEPHLKSFFVRTSDPTHIKLLKLDILTN 431
Cdd:pfam01602  248 TANTIVHLAPAPElIVLAVNALGRLLSSPDEnLRYVALRNLNKIVMKEpKAVQHLDLIIFCLKTDDDISIRLRALDLLYA 327
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   432 LASAGSISLILREFQTYISS-SDRSFVAATIQAIGRCASSIKEVTETCLSGLVHLLSNHDEHVVAESVVVIKRLLQTKAA 510
Cdd:pfam01602  328 LVNESNVKEIVKELLKYVHEiADPDFKIELVRAIGRLAEKFPTDAEWYLDVLLDLLSLAGSYVVDEIVEVIRDIIQNVPE 407
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   511 EHFEIITQMAKLIDYINVPAARAAIIWLIGEYNEKVP--LIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNPEQT- 587
Cdd:pfam01602  408 LREYILEHLCELLEDIESPEALAAALWILGEYGELIPngSSPPDLLRSILEVFVLESAKVRAAALTALAKLGLTSPEETt 487
                          570       580       590
                   ....*....|....*....|....*....|....*.
gi 665389571   588 -SLLCQYVFTLARYD-PNYDVRDRARFLRQIIFPAS 621
Cdd:pfam01602  488 qNLIIQLLLTLATQDsLDLEVRDRAVEYLRLLSLAD 523
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
52-640 4.43e-65

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 235.78  E-value: 4.43e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   52 LDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQL 131
Cdd:COG5096    28 LESSNDYKKIDAMKKIIAQMSLGEDMSSLFPDVIKNVATRDVELKRLLYLYLERYAKLKPELALLAVNTIQKDLQDPNEE 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  132 IRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLYSLDADQKDELVMVIEK--LLSDRTTLVVGSAV 209
Cdd:COG5096   108 IRGFALRTLSLLRVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYRLDKDLYHELGLIDILkeLVADSDPIVIANAL 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  210 MAFDEVCPER-VDLIHKNYRKLCNF----LLDVDEWGQVIIINMLTRYArtqfvdpnaddedlvndglgetpvserfyde 284
Cdd:COG5096   188 ASLAEIDPELaHGYSLEVILRIPQLdllsLSVSTEWLLLIILEVLTERV------------------------------- 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  285 sshssshsddgssddeknksstnnknngggngsrtPSSPSnsyhidvDHRLLLRQTKPLLQSRNASVVM-AVAQLYHHV- 362
Cdd:COG5096   237 -----------------------------------PTTPD-------SAEDFEERLSPPLQHNNAEVLLiAVKVILRLLv 274
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  363 -APKNEVQLIAKALIRLLRSHKE--VQSVVLNCIASMSTKRKAIFEPHLKSFFVRTSDPTHIKLLKLDILTNLASAGSIS 439
Cdd:COG5096   275 fLPSNNLFLISSPPLVTLLAKPEslIQYVLRRNIQIDLEVCSKLLDKVKKLFLIEYNDDIYIKLEKLDQLTRLADDQNLS 354
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  440 LILREFQTYISSS--DRSFVAATIQAIGRCASSIKEVTETCLSGLVHLLSNHDEHV-----VAESVVVIK---------R 503
Cdd:COG5096   355 QILLELIYYIAENhiDAEMVSEAIKALGDLASKAESSVNDCISELLELLEGVWIRGsyivqEVRIVDCISvirisvlvlR 434
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  504 LLQTKA--------AEHFEIITQMAKLIDYINVpAARAAIIWLIGEYNEKVPLIAPDVLRKMAKSFVDEQDVVKLQVLNL 575
Cdd:COG5096   435 ILPNEYpkillrglYALEETLELQSREPRAKSV-TDKYLGAWLLGEFSDIIPRLEPELLRIAISNFVDETLEVQYTILMS 513
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665389571  576 GVKLYLTNPeqTSLLC---QYVFTLARYDPNY----DVRDRARFLrqiifpASGTSSVLSQHARQVFLASKP 640
Cdd:COG5096   514 SVKLIANSI--RKAKQcnsELDQDVLRRCFDYvlvpDLRDRARMY------SRLLSTPLPEFSDPILCEAKK 577
AP3B1_C pfam14796
Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of ...
881-1019 2.54e-61

Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of the clathrin-adaptor protein complex-3 beta-1 subunit. The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules.


Pssm-ID: 464319  Cd Length: 148  Bit Score: 205.96  E-value: 2.54e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   881 IPPIGPVMTPSLGGFLTPGTPMMAGQAAPLQpqhARNRVELVGPSHIEFKHKELLNKVSGHGLHLAYRFTRSPHLYSSSM 960
Cdd:pfam14796   13 FSPSSPVMTPSLGGFLSPSLATDLEGLSLTD---SSSAIEVVSPSFVPTKTHELLHRMTGEGLSVEYRFTRQPCIYSPKM 89
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 665389571   961 CSIELQFQNRGEKEITAIRLGQTTLPAGMQLNEFAPITVLQPQQTASGVLGVDFNDSTH 1019
Cdd:pfam14796   90 VSVELTFTNTSDSEITNIHIGEKKLPAGMRIHEFAEIESLEPGASATVVMGIDFCDSTQ 148
PTZ00429 PTZ00429
beta-adaptin; Provisional
34-681 2.34e-48

beta-adaptin; Provisional


Pssm-ID: 240415 [Multi-domain]  Cd Length: 746  Bit Score: 185.52  E-value: 2.34e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   34 GAAFFQSDGR-KHDDLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQD 112
Cdd:PTZ00429   22 GSKYFAQTRRgEGAELQNDLNGTDSYRKKAAVKRIIANMTMGRDVSYLFVDVVKLAPSTDLELKKLVYLYVLSTARLQPE 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  113 LALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLYS------LDADQK 186
Cdd:PTZ00429  102 KALLAVNTFLQDTTNSSPVVRALAVRTMMCIRVSSVLEYTLEPLRRAVADPDPYVRKTAAMGLGKLFHddmqlfYQQDFK 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  187 DELVmvieKLLSDRTTLVVGSA---VMAFDEVCPERVDLIHKNYRKLCNFLLDVDEWGQVIIINMLTryartqfvdpnad 263
Cdd:PTZ00429  182 KDLV----ELLNDNNPVVASNAaaiVCEVNDYGSEKIESSNEWVNRLVYHLPECNEWGQLYILELLA------------- 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  264 DEDLVNDGLGETPVSerfydesshssshsddgssddeknksstnnknngggngsrtpsspsnsyhidvdhRLLLRqtkpl 343
Cdd:PTZ00429  245 AQRPSDKESAETLLT-------------------------------------------------------RVLPR----- 264
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  344 LQSRNASVVMAVAQLYHHVAPKNEVQLIAK-------ALIRLLRSHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTS 416
Cdd:PTZ00429  265 MSHQNPAVVMGAIKVVANLASRCSQELIERctvrvntALLTLSRRDAETQYIVCKNIHALLVIFPNLLRTNLDSFYVRYS 344
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  417 DPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDRSFVAATIQAIGRCASSIKEVTETCLSGLVHLLSNHDE---HV 493
Cdd:PTZ00429  345 DPPFVKLEKLRLLLKLVTPSVAPEILKELAEYASGVDMVFVVEVVRAIASLAIKVDSVAPDCANLLLQIVDRRPEllpQV 424
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  494 VAESVVVIKR-----LLQTKAAEHFEiitqmakliDYINVPAARAAIIWLIGEYNEKVPlIAPDVLRKMAKSFVDEQDVV 568
Cdd:PTZ00429  425 VTAAKDIVRKypellMLDTLVTDYGA---------DEVVEEEAKVSLLWMLGEYCDFIE-NGKDIIQRFIDTIMEHEQRV 494
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  569 KLQVLNLGVKLYLTNP---EQTslLCQYVFTLARYDPNYDVRDRA----RFLRQIIFPASGTSSVLSQHArqvflaskPA 641
Cdd:PTZ00429  495 QLAILSAAVKMFLRDPqgmEPQ--LNRVLETVTTHSDDPDVRDRAfaywRLLSKGITVAQMKKVVHGQMV--------PV 564
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 665389571  642 PVpESKYRDGnnFQLGSLSHYLNMPAAGYKElPAFPVIPP 681
Cdd:PTZ00429  565 NV-DSTFSDA--MTMADLKKSLNTAAIVFAR-PYQSFLPP 600
Cnd1 pfam12717
non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of ...
131-269 1.63e-17

non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.


Pssm-ID: 463677 [Multi-domain]  Cd Length: 162  Bit Score: 80.97  E-value: 1.63e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   131 LIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLYS----LDADQKDELVmvieKLLSDRTTLVVG 206
Cdd:pfam12717    1 LIRALAIRTMGCIRFPNLVEYLTEPLYRRLKDEDPYVRKTAAMCVAKLILpdmvKVKGFISELA----KLLEDPNPMVVA 76
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665389571   207 SAVMAFDEVCPERVDLIHKNYRKLCNFLLD----VDEWGQVIIINMLTRYartqfVDPNADD-EDLVN 269
Cdd:pfam12717   77 NALAALTEISEKDPNAIYNLLPDIISKLSDalneCSEWGQIYILDFLASY-----IPKDKQEaESLVE 139
HEAT COG1413
HEAT repeat [General function prediction only];
117-211 3.35e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 47.70  E-value: 3.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  117 SISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSaadlSPYVRKTAAHAIPKLYSLDAdqkdelVMVIEKL 196
Cdd:COG1413    48 AVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAALKDE----DPEVRRAAAEALGRLGDPAA------VPALLEA 117
                          90
                  ....*....|....*
gi 665389571  197 LSDRTTLVVGSAVMA 211
Cdd:COG1413   118 LKDPDWEVRRAAARA 132
HEAT COG1413
HEAT repeat [General function prediction only];
117-220 1.08e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.16  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571  117 SISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSaadlSPYVRKTAAHAIPKLYSLDADQkdelvmVIEKL 196
Cdd:COG1413    17 AVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALKDP----DPEVRAAAAEALGRIGDPEAVP------ALIAA 86
                          90       100
                  ....*....|....*....|....
gi 665389571  197 LSDRTTLVVGSAVMAFDEVCPERV 220
Cdd:COG1413    87 LKDEDPEVRRAAAEALGRLGDPAA 110
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
122-211 4.92e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 43.10  E-value: 4.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389571   122 QRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSaadlSPYVRKTAAHAIPKLYSLDADQKdelvmVIEKLLSDRT 201
Cdd:pfam13646    6 QALLRDPDPEVRAAAIRALGRIGDPEAVPALLELLKDE----DPAVRRAAAEALGKIGDPEALPA-----LLELLRDDDD 76
                           90
                   ....*....|
gi 665389571   202 TLVVGSAVMA 211
Cdd:pfam13646   77 DVVRAAAAEA 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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