NCBI Conserved Domain Search

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 273.23 E-value: 8.89e-85

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  488 FYDAQVEFVKNPSEFWIRLRKHNVTFSKLMRRMCGFYSSASKLDGVVLKPEPDDLCCVKWKENGYYRAIVTKLDDKSVDV 567
Cdd:cd20422     1 FYDAQVEFVKDPSEFWIRLGEHAVPFSKLMRSMTAFYSQASKLDGVVLKPQPGQLCCAKWKEDRYYRAIVTAVKGKMVEV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 270132304  568 FLVDRGNSENVDWYDVRMLLPQFRQLPILAVKCTLADIWPLGKTWSQEAVSFFKK 622
Cdd:cd20422    81 FLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFKR 135

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 259.74 E-value: 6.38e-80

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1521 IRAYATVIDGPEYFWCQFAdTEKLQCLEVEVQTAGEQVADRRNCIPCPYIGDPCIVRYREDGHYYRALITNICeDYLVSV 1600
Cdd:cd20426     1 IEAYATAVDSPEYFWCQFA-TEKIQCLAVKVQEAGEQVADRGNFIPSIYVGDPCIVKYSEDNHWYRALVTKIN-DNLVSV 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 270132304 1601 RLVDFGNIEDCVdPKALWAIPSELLSVPMQAFPCCLSGFNISEGLCSQEGNDYFYEIITEDVL 1663
Cdd:cd20426    79 RFVDYGNEEDVV-REQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYFYEIVTEDLL 140

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 251.96 E-value: 2.02e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  240 DYFYPQLQLGVTEAVVITQVCHPHRIHCQLRSVSQEIHRLSESMAQVYRGSTGTGDEnstsatweereESPDKPGSPCAS 319
Cdd:cd20421     1 DYFYPQLQVGVTETVVVTEVTDPHRIFCQLRSLSQELKRLSESMHQYYEGRVGSGYE-----------TRPEKLGSPCAA 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 270132304  320 CGLDGHWYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYG 380
Cdd:cd20421    70 RGSDGRWYRAVLQQVFSANRVVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 234.32 E-value: 2.50e-71

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  975 YFYSTHDMKIGSEELVYITHIDDPWTFYCQLARNANILEQLSCSITQLSKVLLNLKTsPLNPGTLCLAKYTDGNWYRGIV 1054
Cdd:cd20424     1 YYYSMHDIKIGSEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRLSSEIRKLEL-SVNPGTLCLAKYSDQHWYRGII 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 270132304 1055 IE-KEPKKVFFVDFGNIYVVTSDDLLPIPSDAYDVLLLPMQAVRCSL 1100
Cdd:cd20424    80 ITnKNSTEVFFVDYGNTEKVEKEDMLPIPSDAYELLLLPMQAIKCSL 126

first Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410491 Cd Length: 132 Bit Score: 232.32 E-value: 1.72e-70

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304    6 GMPAPGASLALRVSFVDVHPDVIPVQLWGLVGERRGEYLRLSREIQEAAATRGQ-WALGSASASPGELCLVQVGLLWHRC 84
Cdd:cd20420     1 GLPAPGAVLSLRVSRVDVRPGVPLVRLWGLLRERKGEYQRLTREIQAAVKMRGCgAGDGGAEPSVGDLCLVEVGGLWHRC 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 270132304   85 RVVSRQAQESRVFLLDEGRTITAGAGSLAPGRREFFNLPSEVLGCVLAGLVP 136
Cdd:cd20420    81 RVVSRQGDDYRVFLLDEGRTVVARAKSLARGRKDFFSLPPEVLGCVLANLVP 132

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 210.01 E-value: 6.70e-63

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1306 KTTVYVSHINDLSDFYVQLIEDEAEISHLSERLNSVKTRPEYYVGPPLQRGDMICAVFPEDNLWYRAVIKEQQPNDLLSV 1385
Cdd:cd20425     1 KTEVYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVECESLQLGDLICAEYPEDGLWYRAVVKEKIPNNLVSV 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 270132304 1386 QFIDYGNVSVVHTNKIGRLDLVNAILPGLCIHCSL 1420
Cdd:cd20425    81 QFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 145.29 E-value: 4.30e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  977 YSTHDMKIGSEELVYITHIDDPWTFYCQLARNANILEQLSCSITQLSKvLLNLKTSPLNPGTLCLAKY-TDGNWYRGIVI 1055
Cdd:cd20440     1 YSSFNIKVGSEEEVYITHVYSPAKFYCQLDRNTEILEALMEKIAEISK-LFNSQILDNCKTRLCLAKYfEDGQWYRALAH 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 270132304 1056 EKEPK---KVFFVDFGNIYVVTSDDLLPIPSDAYDVLLLPMQAVRCSL 1100
Cdd:cd20440    80 PVESSshlSVYFVDYGNKQIVEKNEVLPIPDTAVDLLLTPMQAIKCCL 127

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 143.38 E-value: 2.73e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  483 LKMNAFYDAQVEFVKNPSEFWIRLRKHNVTFSKLMRRMCGFYSSASKLDGVVLKPEPDDLCCVKW-KENGYYRAIVTKLD 561
Cdd:cd20438     1 MEVDAAYVAFVEYVLNPSNFWIRTDEYNNEFQALMKNIADIYNLCGNDEELLKKPEPGLLCCARYsKDRHYYRAVITEVL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 270132304  562 DKSVDVFLVDRGNSENVDWYDVRMLLPQFRQLPILAVKCTLADIWPLGKTWSQEAVSFFKK 622
Cdd:cd20438    81 DLKVSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWTKNANDFFKK 141

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 135.69 E-value: 2.12e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  815 PHQRNTLACLAKRTVNRQWSRALISGIQS-VEHVNVTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSLYNLIQPVGQ 893
Cdd:cd20423     1 PHSLPNPVCLAKYSEDGKWCRALIDNVYEpVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSGQ 80

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 128.76 E-value: 2.01e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  768 LEVGSTVEVRVSYVENPGYFWCQLTRNIQGLKTLMSDIQYYCKNTAAPHQRNTLACLAKRTVNRQWSRALISGIQSVEHV 847
Cdd:cd20439     6 FKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSLMKQIQSYYLIHNDPYKHGQIACVAKYSKDGKWYRAAVLKQVSAKEV 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 270132304  848 NVTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSLYNL 887
Cdd:cd20439    86 DVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 124.39 E-value: 5.54e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  1309 VYVSHINDLSDFYVQLIEDEAEISHLSERLNSVKTRPEYyVGPPLQRGDMICAVFPEDNLWYRAVIKEQQPNDLLSVQFI 1388
Cdd:pfam00567    5 VVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPP-ESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVEVLFI 83

                           90       100       110
                   ....*....|....*....|....*....|....
gi 270132304  1389 DYGNVSVVHTNKIGRLDLVNAILPGLCIHCSLQG 1422
Cdd:pfam00567   84 DYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 115.53 E-value: 8.18e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  1519 KMIRAYATVIDGPEYFWCQF-ADTEKLQCLEVEVQTAGEQVAdrRNCIPcPYIGDPCIVRYREDGHYYRALITNICEDYL 1597
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPkSDSKKLEKLTEELQEYYASKP--PESLP-PAVGDGCVAAFSEDGKWYRAKITESLDDGL 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 270132304  1598 VSVRLVDFGNIEdCVDPKALWAIPSELLSVPMQAFPCCLSG 1638
Cdd:pfam00567   78 VEVLFIDYGNTE-TVPLSDLRPLPPELESLPPQAIKCQLAG 117

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 102.82 E-value: 2.06e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304   772 STVEVRVSYVENPGYFWCQLTRNIQGLKTLMSDIQYYCKNTAAPHQRNTL--ACLAKRTVNRQWSRALISGIQSVEHVNV 849
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVgdGCVAAFSEDGKWYRAKITESLDDGLVEV 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 270132304   850 TFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSLYN 886
Cdd:pfam00567   81 LFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 97.04 E-value: 1.84e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304   990 VYITHIDDPWTFYCQLARNANILEQLSCSITQLSKVLLNLkTSPLNPGTLCLAKYT-DGNWYRGIVIEKEPK---KVFFV 1065
Cdd:pfam00567    5 VVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPE-SLPPAVGDGCVAAFSeDGKWYRAKITESLDDglvEVLFI 83

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 270132304  1066 DFGNIYVVTSDDLLPIPSDAydvLLLPMQAVRCSLSD 1102
Cdd:pfam00567   84 DYGNTETVPLSDLRPLPPEL---ESLPPQAIKCQLAG 117

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 91.73 E-value: 1.24e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1318 SDFYVQLIEDEAEISHLSERLNSVKTRPEYYVGPPLQRGDMICAVFPEDNLWYRAVIKEQQPNDLLSVQFIDYGNVSVVH 1397
Cdd:cd20441     3 SRFFIQLSEDEKVILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGNTAVVD 82

                          90       100
                  ....*....|....*....|....*
gi 270132304 1398 TNKIGRLDLVNAILPGLCIHCSLQG 1422
Cdd:cd20441    83 KSNIYTLQEKFLSLPRLSIPCSLSG 107

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 86.64 E-value: 8.10e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304   487 AFYDAQVEFVKNPSEFWIRLRKHNVTFSKLMRRMCGFYSSASKLDgvvLKPEPDDLCCVKWKENG-YYRAIVTK-LDDKS 564
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPES---LPPAVGDGCVAAFSEDGkWYRAKITEsLDDGL 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 270132304   565 VDVFLVDRGNSENVDWYDVRMLLPQFRQLPILAVKCTLAD 604
Cdd:pfam00567   78 VEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 85.20 E-value: 4.53e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  768 LEVGSTVEVRVSYVENPGYFWCQLTRNIQGLKTLMSDIQYYCK--NTAAPHQRNTLACLAKRTVNRQWSRALISGIQSVE 845
Cdd:cd20440     6 IKVGSEEEVYITHVYSPAKFYCQLDRNTEILEALMEKIAEISKlfNSQILDNCKTRLCLAKYFEDGQWYRALAHPVESSS 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 270132304  846 HVNVTFVDYGDREMVSVKNIYSISEEF---LKVKAQAFRCSL 884
Cdd:cd20440    86 HLSVYFVDYGNKQIVEKNEVLPIPDTAvdlLLTPMQAIKCCL 127

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 80.93 E-value: 2.49e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304   16 LRVSFVDVHPDVIPVQLWG-LVGERRGEYLRLSREIQEAAATRGQWALGsasaspgELCLVQ--VGLLWHRCRVVSRQAQ 92
Cdd:cd20436     2 LKITHRVCHPKEVLVKFQGqYNSICELDYHILQNEIQNATKSKSSWGVG-------EFCLVEdtTSGEWYRGRVLEKIDE 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 270132304   93 ESRVFLLDEGRTITAGAGSLAPGRREFFNLPSEVLGCVLAGLVPAGcgagsgeppQHWPADAVDFLSNLQGKEVHG 168
Cdd:cd20436    75 KYEVFLIDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIG---------EKWSSTAVNYFSSLIGSQVKG 141

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 78.61 E-value: 7.26e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  249 GVTEAVVITQVCHPHRIHCQLRSVSQEIHRLSESMAQVYRGSTGTGDEnstsatweereeSPDKPGSPCASCGLDGHWYR 328
Cdd:cd20437     2 GTTEKVKITAAVSPSKFYCQLLSWEPELSKLTTQMTLHYESVSKELNP------------SCENFGLLCAAKGKDGQWHR 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 270132304  329 ALLlETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCAL 378
Cdd:cd20437    70 GFL-QQLLPPSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 77.46 E-value: 1.81e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  770 VGSTVEVRVSYVENPGYFWCQLTRNIQGLKTLMSDIQYYC----KNTAAPHQRNTLACLAKRTvNRQWSRALISGIQSVE 845
Cdd:cd20437     1 VGTTEKVKITAAVSPSKFYCQLLSWEPELSKLTTQMTLHYesvsKELNPSCENFGLLCAAKGK-DGQWHRGFLQQLLPPS 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 270132304  846 HVNVTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSL 884
Cdd:cd20437    80 QVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 77.07 E-value: 2.13e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  984 IGSEELVYITHIDDPWTFYCQLARNANILEQLSCSITqLSKVLLNLKTSPL--NPGTLCLAKYTDGNWYRGIVIEKEPK- 1060
Cdd:cd20437     1 VGTTEKVKITAAVSPSKFYCQLLSWEPELSKLTTQMT-LHYESVSKELNPSceNFGLLCAAKGKDGQWHRGFLQQLLPPs 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 270132304 1061 --KVFFVDFGNIYVVTSDDLLPIPSdayDVLLLPMQAVRCSLSD 1102
Cdd:cd20437    80 qvKVWFIDYGNSEAVSSHSVLKLPP---DFFSLPLMSFPCSLSC 120

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 77.41 E-value: 2.35e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  493 VEFvKNPSEFWIRLRKHNV--TFSKLMRRMCGFYSSASKLDGVVlkPEPDDLCCVKWKENG-YYRAIVTKLD--DKSVDV 567
Cdd:cd20408     4 TEF-KNPGEFYIQIYTLEVleSLVKLTSQLKKTYASVNNHKEYI--PEVGEVCVAKYSEDQnWYRALVQTVDvqQKKAGV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 270132304  568 FLVDRGNSENVDWYDVRMLLPQFRQLPILAVKCTLADIWPLGKTWSQEAV 617
Cdd:cd20408    81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 75.61 E-value: 1.24e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  774 VEVRVSYVENPGYFWCQL-TRNIQGLKTLMSDIqyyckNTAAPHQRNTLA-------CLAKRTVNRQWSRALISGIQSvE 845
Cdd:cd20426     1 IEAYATAVDSPEYFWCQFaTEKIQCLAVKVQEA-----GEQVADRGNFIPsiyvgdpCIVKYSEDNHWYRALVTKIND-N 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 270132304  846 HVNVTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSLYNLIQPVGqnpfVWDVKAIQAFNEFI 910
Cdd:cd20426    75 LVSVRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEG----LWSDEANDYFYEIV 135

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 74.41 E-value: 2.74e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1524 YATVIDGPEYFWCQFA-DTEKLQCLEVEVQTAGEQVADRrncIPCPYIGDPCIVRYREDGHYYRALITNICEDYLVSVRL 1602
Cdd:cd20440    15 YITHVYSPAKFYCQLDrNTEILEALMEKIAEISKLFNSQ---ILDNCKTRLCLAKYFEDGQWYRALAHPVESSSHLSVYF 91

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 270132304 1603 VDFGNIEdCVDPKALWAIP---SELLSVPMQAFPCCL 1636
Cdd:cd20440    92 VDYGNKQ-IVEKNEVLPIPdtaVDLLLTPMQAIKCCL 127

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 74.38 E-value: 2.82e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  975 YFYSthDMKIGSEELVYITHIDDPWTFYCQLARNANILEQLSCSITQL--SKVLLNLKTSPLNPGTLCLAKYTDGNWYRG 1052
Cdd:cd20421     2 YFYP--QLQVGVTETVVVTEVTDPHRIFCQLRSLSQELKRLSESMHQYyeGRVGSGYETRPEKLGSPCAARGSDGRWYRA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 270132304 1053 IVIEKEPKK----VFFVDFGNIYVVTSDDLLPIPSDAYDvllLPMQAVRCSL 1100
Cdd:cd20421    80 VLQQVFSANrvveVLHVDYGRKEVVSVSNLRYLAPEYFR---MPVVTYPCAL 128

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 68.66 E-value: 6.63e-14

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 270132304  311 DKPGSPC-ASCGLDGHWYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGL 381
Cdd:cd20423     3 SLPNPVClAKYSEDGKWCRALIDNVYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNL 74

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 68.26 E-value: 2.84e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1320 FYVQLIEDE--AEISHLSERLNSVKTRPEYYVGPPlQRGDMICAVFPEDNLWYRAVIKE------QQPNDLLSVQFIDYG 1391
Cdd:cd20443     4 FYVQVVSDQrlSSIQQQLEGLSLKDKANPPGGFNP-KKGELVLAQFSADNSWNRAMVVNaprqgtQSPKDEYEVFYIDYG 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 270132304 1392 NVSVVHTNKIGRLDLVNAILPGLCIHCSLQGFEVP 1426
Cdd:cd20443    83 NQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKVP 117

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 67.91 E-value: 4.27e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  764 SKGELEVGSTVEVRVSYVENPGYFWCQLTRNIQGLKTLMSDIQYYCK---NTAAPHQRNTLaCLAKRTvNRQWSRALIsg 840
Cdd:cd20424     4 SMHDIKIGSEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRLSSeirKLELSVNPGTL-CLAKYS-DQHWYRGII-- 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 270132304  841 IQSVEHVNVTFVDYGDREMVSVKNIYSI---SEEFLKVKAQAFRCSL 884
Cdd:cd20424    80 ITNKNSTEVFFVDYGNTEKVEKEDMLPIpsdAYELLLLPMQAIKCSL 126

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 67.09 E-value: 5.86e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  776 VRVSYVENPGYFWC---QLTRNIQGLKTLMSDIQYYCKNTAAP---HQRNTLACLAKRTVNRQWSRALISGIqSVEHVNV 849
Cdd:cd20411     1 ALVLEVISPDLFYAlpkTGQVNVEKLKALMTELAEYCSKQSVPqqfRPRIGDACCARFTGDKNWYRAVVLET-SDSEVKV 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 270132304  850 TFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSL 884
Cdd:cd20411    80 LYADYGNTETLPLSRILPITKSHLELPFQIIRCSL 114

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 64.38 E-value: 4.58e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1531 PEYFWCQFADTEKlqcleVEVQTAGE----QVADRRNCIPCPYIGDPCIVRYREDGHYYRALITNICEDYLVSVRLVDFG 1606
Cdd:cd20441     2 PSRFFIQLSEDEK-----VILQLAEElnetSEKSRENAAVKLKVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYG 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 270132304 1607 NIEdCVDPKALWAIPSELLSVPMQAFPCCLSG 1638
Cdd:cd20441    77 NTA-VVDKSNIYTLQEKFLSLPRLSIPCSLSG 107

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 64.70 E-value: 5.59e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  990 VYITHIDDPWTFYCQLARNaNILEQLSCSITQLSKVLLNLKT-SPLNP--GTLCLAKYT-DGNWYRGIV----IEKEPKK 1061
Cdd:cd20408     1 GTVTEFKNPGEFYIQIYTL-EVLESLVKLTSQLKKTYASVNNhKEYIPevGEVCVAKYSeDQNWYRALVqtvdVQQKKAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 270132304 1062 VFFVDFGNIYVVTSDDLLPIPSdayDVLLLPMQAVRCSLSDIPDH 1106
Cdd:cd20408    80 VFYIDYGNEETVPLNRIQPLKK---DIELFPPCAIKCCLANVKPP 121

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 64.43 E-value: 7.27e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  483 LKMNAFYDAQVEFVKNPSEFWIRLRKHNVTFSKLMRRMCGFYSSASKLDgvvlkpEPDDLCCV-KWKENG-YYRA-IVTK 559
Cdd:cd20439     6 FKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSLMKQIQSYYLIHNDPY------KHGQIACVaKYSKDGkWYRAaVLKQ 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 270132304  560 LDDKSVDVFLVDRGNSENVDWYDVRMLLPQFRQLPILAVKCTLADI 605
Cdd:cd20439    80 VSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 64.05 E-value: 9.26e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  977 YSTHDMKIGSEELVYITHIDDPWTFYCQLARNANILEQLSCSITQLSKVllnlKTSPLNPG-TLCLAKYT-DGNWYRGIV 1054
Cdd:cd20439     1 YKEYLFKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSLMKQIQSYYLI----HNDPYKHGqIACVAKYSkDGKWYRAAV 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 270132304 1055 IEKEPKK---VFFVDFGNIYVVTSDDLLPIPSDaydVLLLPMQAVRCSLSDI 1103
Cdd:cd20439    77 LKQVSAKevdVIFVDYGNQERVLISDLRAIKPQ---FLLLEGQAFRCSLNNF 125

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 64.05 E-value: 9.35e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1528 IDGPEYFWCQfadtekLQCLEVEVQTAGEQVADRRNCIPCPY-IGD-PCIVRYREDGHYYRALITNICEDYLVSVRLVDF 1605
Cdd:cd20439    19 VNSPGDFWCQ------LQTKSSELKSLMKQIQSYYLIHNDPYkHGQiACVAKYSKDGKWYRAAVLKQVSAKEVDVIFVDY 92

                          90       100       110
                  ....*....|....*....|....*....|....
gi 270132304 1606 GNIEDcVDPKALWAIPSELLSVPMQAFPCCLSGF 1639
Cdd:cd20439    93 GNQER-VLISDLRAIKPQFLLLEGQAFRCSLNNF 125

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 64.75 E-value: 9.55e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  540 DDLCCVKWKENG-YYRAIVTKLDDKSVDVFLVDRGNSENVDWYDVRMLLPQFRQLPILAVKCTLADIWPLGKTWSQEAVS 618
Cdd:cd20436    50 GEFCLVEDTTSGeWYRGRVLEKIDEKYEVFLIDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIGEKWSSTAVN 129


                  ....*.
gi 270132304  619 FFKKTV 624
Cdd:cd20436   130 YFSSLI 135

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 64.44 E-value: 1.17e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  991 YITHIDDPWTFYCQLA-RNANILEQLSCSITQLSKVLLNLKTSPlNPGTLCLAKYT-DGNWYRGIV--IEKEPKKVFFVD 1066
Cdd:cd20426     4 YATAVDSPEYFWCQFAtEKIQCLAVKVQEAGEQVADRGNFIPSI-YVGDPCIVKYSeDNHWYRALVtkINDNLVSVRFVD 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 270132304 1067 FGNIYVVTSDDLLPIPSdayDVLLLPMQAVRCSLS 1101
Cdd:cd20426    83 YGNEEDVVREQVRALPS---ELLKIPVQAFPCCLS 114

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 62.85 E-value: 1.97e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1540 DTEKLQCLEVEVQTAGEQVADRRNCIPcpYIGDPCIVRYREDGHYYRALITNICEDYlVSVRLVDFGNIEdCVDPKALWA 1619
Cdd:cd20411    22 NVEKLKALMTELAEYCSKQSVPQQFRP--RIGDACCARFTGDKNWYRAVVLETSDSE-VKVLYADYGNTE-TLPLSRILP 97

                          90
                  ....*....|....*....
gi 270132304 1620 IPSELLSVPMQAFPCCLSG 1638
Cdd:cd20411    98 ITKSHLELPFQIIRCSLAG 116

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 62.76 E-value: 2.26e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304   251 TEAVVITQVCHPHRIHCQLRSVSQEIHRLSESMAQVYRGStgtgdenstsatweEREESPDKPGSPCA---SCglDGHWY 327
Cdd:pfam00567    2 TIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASK--------------PPESLPPAVGDGCVaafSE--DGKWY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 270132304   328 RALLLETfRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYG 380
Cdd:pfam00567   66 RAKITES-LDDGLVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 60.37 E-value: 2.79e-11

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 270132304   1351 PPLQRGDMICAVFpEDNLWYRAVIKEQQPNDLLSVQFIDYGNVSVVHTNKIGRLDL 1406
Cdd:smart00333    1 PTFKVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPE 55

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 59.84 E-value: 3.29e-11

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 270132304 1356 GDMICAVFPEDNLWYRAVIKEQQPNDLLSVQFIDYGNVSVVHTNKIGRL 1404
Cdd:cd20379     2 GDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 62.05 E-value: 3.92e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  492 QVEFVK-----NPSEFWIRLRKHNVTFSKLMRRMCGFYSSASKlDGVVLKPEPDDLCCVKWKENGYYRAIV-TKLDDKSV 565
Cdd:cd20437     3 TTEKVKitaavSPSKFYCQLLSWEPELSKLTTQMTLHYESVSK-ELNPSCENFGLLCAAKGKDGQWHRGFLqQLLPPSQV 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 270132304  566 DVFLVDRGNSENVDWYDVRMLLPQFRQLPILAVKCTLAD 604
Cdd:cd20437    82 KVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLSC 120

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 62.05 E-value: 4.28e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1304 GFKTTVYVSHINDLSDFYVQLIEDEAEISHLSERLNSVKTRPEYYVGPPLQRGDMICAVFPEDNLWYRAVIKEQQPNDLL 1383
Cdd:cd20437     2 GTTEKVKITAAVSPSKFYCQLLSWEPELSKLTTQMTLHYESVSKELNPSCENFGLLCAAKGKDGQWHRGFLQQLLPPSQV 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 270132304 1384 SVQFIDYGNVSVVHTNKIGRLDLVNAILPGLCIHCSL 1420
Cdd:cd20437    82 KVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 62.11 E-value: 6.58e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1523 AYATVIDGPEYFWCQfadTEKLQClevEVQTAGEQVADRRNciPC---------PYIGDPCIVRYREDGHYYRALITNIC 1593
Cdd:cd20438     9 AFVEYVLNPSNFWIR---TDEYNN---EFQALMKNIADIYN--LCgndeellkkPEPGLLCCARYSKDRHYYRAVITEVL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 270132304 1594 eDYLVSVRLVDFGNIE--DCVDPKALwaIPsELLSVPMQAFPCCLSGFNISEGLCSQEGNDYF 1654
Cdd:cd20438    81 -DLKVSVYFLDFGNTDtvPFYDVKTL--LP-EFSELPALAMCCSLAHVFPVEEVWTKNANDFF 139

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 58.68 E-value: 8.32e-11

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 270132304 1036 PGTLCLAKYT-DGNWYRGIVIEKEPK---KVFFVDFGNIYVVTSDDLLPI 1081
Cdd:cd20379     1 VGDLCAAKYEeDGKWYRARVLEVLSNdkvEVFFVDYGNTETVPLSDLRPL 50

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 58.82 E-value: 9.66e-11

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 270132304   1566 PCPYIGDPCIVRYrEDGHYYRALITNICEDYLVSVRLVDFGNIEdCVDPKALWAIPSEL 1624
Cdd:smart00333    1 PTFKVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEE-VVPPSDLRQLPEEL 57

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 58.30 E-value: 1.25e-10

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 270132304 1570 IGDPCIVRYREDGHYYRALITNICEDYLVSVRLVDFGNIEdCVDPKALWAI 1620
Cdd:cd20379     1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTE-TVPLSDLRPL 50

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 60.52 E-value: 1.72e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  767 ELEVGSTVEVRVSYVENPGYFWCQLTRNIQGLKTLMSDI-QYYCKNTAAPHQ---RNTLACLAKRTVNRQWSRAL----I 838
Cdd:cd20421     6 QLQVGVTETVVVTEVTDPHRIFCQLRSLSQELKRLSESMhQYYEGRVGSGYEtrpEKLGSPCAARGSDGRWYRAVlqqvF 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 270132304  839 SGIQSVEhvnVTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSLY 885
Cdd:cd20421    86 SANRVVE---VLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALF 129

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 58.12 E-value: 2.06e-10

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 270132304 1568 PYIGDPCIVRYREDGHYYRALITNICEDYLVSVRLVDFGNIEDcVDPKALWAIPSELL 1625
Cdd:cd20410     3 PIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEE-VTLDKLRKITSTFL 59

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 60.59 E-value: 2.15e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  496 VKNPSEFWIRLRKHNVTFSKLMRRMCGfysSASKLDGVVL-KPEPDDLCCVKWKENG-YYRAIVTKLDDKSVDVFLVDRG 573
Cdd:cd20426     8 VDSPEYFWCQFATEKIQCLAVKVQEAG---EQVADRGNFIpSIYVGDPCIVKYSEDNhWYRALVTKINDNLVSVRFVDYG 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 270132304  574 NSENVDWYDVRMLLPQFRQLPILAVKCTLADIWPLGKTWSQEAVSFF 620
Cdd:cd20426    85 NEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYF 131

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 57.67 E-value: 2.78e-10

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 270132304   1032 SPLNPGTLCLAKYTDGNWYRGIVIEKEPKK---VFFVDFGNIYVVTSDDLLPIPSD 1084
Cdd:smart00333    1 PTFKVGDKVAARWEDGEWYRARIVKVDGEQlyeVFFIDYGNEEVVPPSDLRQLPEE 56

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 59.39 E-value: 3.21e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  989 LVYITHIDDPWTFYCQLARNANileqlscSITQLSKVLLNLKTSP-------LNPGTLCLAKYT-DGNWYRGIVIEKEPK 1060
Cdd:cd20425     3 EVYVSHVNSPSDFYVQLAQDED-------ELSMISEKLNASKANDeevecesLQLGDLICAEYPeDGLWYRAVVKEKIPN 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 270132304 1061 K---VFFVDFGNIYVVTSDDLLPIPSDAydvLLLPMQAVRCSL 1100
Cdd:cd20425    76 NlvsVQFIDYGNTSVVQPSKIHRLPKEL---LSIPALSIHCFL 115

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 59.31 E-value: 4.71e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  778 VSYVENPGYFWCQL--TRNIQGLKTLMSDIQYYCKNTAApHQRNTLA----CLAKRTVNRQWSRALIsgiQSVEHVN--- 848
Cdd:cd20408     3 VTEFKNPGEFYIQIytLEVLESLVKLTSQLKKTYASVNN-HKEYIPEvgevCVAKYSEDQNWYRALV---QTVDVQQkka 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 270132304  849 -VTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSLYNLIQPVG 892
Cdd:cd20408    79 gVFYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSG 123

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 57.49 E-value: 5.58e-10

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 270132304 1573 PCIVRYREDGHYYRALITNICEDY-LVSVRLVDFGNiEDCVDPKALWAIPSELLSVPMQAFPCCL 1636
Cdd:cd20423     8 VCLAKYSEDGKWCRALIDNVYEPVeMVEVTYVDYGN-KELVSLKNLRSISEEFLKLKAQAFRCSL 71

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 56.58 E-value: 7.14e-10

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 270132304 1354 QRGDMICAVFPEDNLWYRAVIKEQQPNDLLSVQFIDYGNVSVVHTNKI 1401
Cdd:cd20410     4 IVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKL 51

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 57.31 E-value: 7.55e-10

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 270132304 1351 PPLQ------RGDMICAVFPEDNLWYRAVIKEQQPNDLLSVQFIDYGNVSVVHTNKIGRLD 1405
Cdd:cd20433    20 PPLPgsytprKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALP 80

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 57.84 E-value: 1.05e-09

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 270132304 1036 PGTLCLAKYT-DGNWYRGIVIEKEPK--KVFFVDFGNIYVVTSDDLLPIpSDAYdvLLLPMQAVRCSLS 1101
Cdd:cd20411    50 IGDACCARFTgDKNWYRAVVLETSDSevKVLYADYGNTETLPLSRILPI-TKSH--LELPFQIIRCSLA 115

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 55.43 E-value: 1.88e-09

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 270132304 1036 PGTLCLAKYT-DGNWYRGIVIEKEPK---KVFFVDFGNIYVVTSDDLLPIPSD 1084
Cdd:cd20410     5 VGEPCCAFFSgDGNWYRAMVKEILPGgavKVHFVDYGNVEEVTLDKLRKITST 57

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 54.83 E-value: 2.31e-09

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 270132304  539 PDDLCCVKWKENG-YYRAIVTKLD-DKSVDVFLVDRGNSENVDWYDVRML 586
Cdd:cd20379     1 VGDLCAAKYEEDGkWYRARVLEVLsNDKVEVFFVDYGNTETVPLSDLRPL 50

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 56.70 E-value: 2.86e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1523 AYATVIDGPEYFWCQFA-DTEKLQCLEvEVQTAGEQVADRRNCIPCPyIGDPCIVRYREDGHYYRALITNICEDYLVSVR 1601
Cdd:cd20425     4 VYVSHVNSPSDFYVQLAqDEDELSMIS-EKLNASKANDEEVECESLQ-LGDLICAEYPEDGLWYRAVVKEKIPNNLVSVQ 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 270132304 1602 LVDFGNIEDcVDPKALWAIPSELLSVPMQAFPCCL 1636
Cdd:cd20425    82 FIDYGNTSV-VQPSKIHRLPKELLSIPALSIHCFL 115

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 55.90 E-value: 3.42e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  520 MCGFYSSASKLDgVVLKPEPDDLCCVKWKENGYYRAIVTKLDDKSVDVFLVDRGNSENVDWYDVRMLLPQFRQLPILAVK 599
Cdd:cd20427     7 MKEFYSKSSTAM-CLRSPSVGQLVAVKAEEDAWLRAQVIEVEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQATK 85


                  ....*....
gi 270132304  600 CTLADIWPL 608
Cdd:cd20427    86 CKLAGLEPF 94

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 55.94 E-value: 5.66e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1001 FYCQLARNANILeqlscSI-TQLSKVLLNLKTSP---LNP--GTLCLAKYT-DGNWYRGIVIE--------KEPK-KVFF 1064
Cdd:cd20443     4 FYVQVVSDQRLS-----SIqQQLEGLSLKDKANPpggFNPkkGELVLAQFSaDNSWNRAMVVNaprqgtqsPKDEyEVFY 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 270132304 1065 VDFGNIYVVTSDDLLPIPSdayDVLLLPMQAVRCSLSDI 1103
Cdd:cd20443    79 IDYGNQETVPLSALRPLDP---SVSSAPGLAQLCSLAHI 114

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 54.61 E-value: 5.93e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 270132304 1020 TQLSKVLLNLKTS-PLNP----------GTLCLAKYT-DGNWYRGIVIEKEPKK---VFFVDFGNIYVVTSDDLLPIPS 1083
Cdd:cd20433     3 PQLEKLMEKLRFEiASNPplpgsytprkGDLCAAKFVeDGEWYRAKVEKVEGDKkvhVLYIDYGNREVLPSTRLAALPP 81

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 56.59 E-value: 7.41e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  766 GELEVGSTVevrvsYVENPGYFWCQLTRNIQGLKTLMSDIQ---YYCKNTAAPHQRNTLACLAKRTVNRQWSRALISGI- 841
Cdd:cd20442     1 GQIEKGTLL-----SVSKNGTFYVRLLRNSEQLTDLESLIAkeaKKCKFVPVEDIKEGLECLAKSKKNLKWYRAVVEHLy 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 270132304  842 QSVEHVNVTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRC 882
Cdd:cd20442    76 PETEKMLVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLC 116

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 55.93 E-value: 7.81e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1301 IMPGFKTTVYVSHINDLSDFYVQLIEDEAEISHLSERLNSVKTRPEYyvgpplQRGDM----IC-AVFPEDNLWYRAVIK 1375
Cdd:cd20440     6 IKVGSEEEVYITHVYSPAKFYCQLDRNTEILEALMEKIAEISKLFNS------QILDNcktrLClAKYFEDGQWYRALAH 79

                          90       100
                  ....*....|....*....|....*.
gi 270132304 1376 EQQPNDLLSVQFIDYGNVSVVHTNKI 1401
Cdd:cd20440    80 PVESSSHLSVYFVDYGNKQIVEKNEV 105

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 54.70 E-value: 9.51e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  494 EFVkNPSEFW-IRLRKHNV-TFSKLMRrmcgfysSASKLDGVVL--KPEPDDLCCVKWK---ENGYYRAIVTKLDDKSVD 566
Cdd:cd20431     2 EVV-EVGHFWgYRIDENSSeILQQLTA-------EINQRQLVPLttKPVPNLLCLAPFTdadMKKYYRAKILYVSGSSAE 73

                          90       100
                  ....*....|....*....|....*...
gi 270132304  567 VFLVDRGNSENVDWYDVRMLLPQFRQLP 594
Cdd:cd20431    74 VFFVDYGNTSQVPSSLLREIPETLLTLP 101

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 54.36 E-value: 1.28e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1037 GTLCLAKYTDGNWYRGIVI---EKEPKKVFFVDFGNIYVVTSDDLLPIPSDAydvLLLPMQAVRCSLSDI 1103
Cdd:cd20415    28 GQACVALFEDGAWYRARIIglpGHREVEVKYVDFGNTATVTIKHVRKIKDDF---LSLPEKARECRLAFI 94

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 55.21 E-value: 1.34e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  997 DPWTFYCQLARNANILEQLSCSITQL---SKVLLNLKTSPlNPGTLCLAKYTDGNWYRGIVIEKEPK--KVFFVDFGNIY 1071
Cdd:cd20422    11 DPSEFWIRLGEHAVPFSKLMRSMTAFysqASKLDGVVLKP-QPGQLCCAKWKEDRYYRAIVTAVKGKmvEVFLVDRGNTE 89

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 270132304 1072 VVtsddllpipsDAYDVLLLPMQ-------AVRCSLSDI 1103
Cdd:cd20422    90 MV----------DWYDVKKLLPQfrelpalALKCCLADI 118

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 54.32 E-value: 1.39e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  993 THIDDPWTFYCQL--ARNANILEQLSCSITQLskVLLNLKTSPLnPGTLCLAKYTDGN---WYRGIV--IEKEPKKVFFV 1065
Cdd:cd20431     1 TEVVEVGHFWGYRidENSSEILQQLTAEINQR--QLVPLTTKPV-PNLLCLAPFTDADmkkYYRAKIlyVSGSSAEVFFV 77

                          90       100
                  ....*....|....*....|....
gi 270132304 1066 DFGNIYVVTSDDLLPIPSDAYDVL 1089
Cdd:cd20431    78 DYGNTSQVPSSLLREIPETLLTLP 101

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 52.13 E-value: 1.81e-08

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 270132304  823 CLAKRTVNRQWSRALISGIQSVEHVNVTFVDYGDREMVSVKNIYSI 868
Cdd:cd20379     5 CAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 52.87 E-value: 2.20e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 270132304 1036 PGTLCLAKYT-DGNWYRGIVIE----KEPKKVFFVDFGNIYVVTSDDLLPIPSDaydVLLLPMQAVRCSLSDI 1103
Cdd:cd20423     5 PNPVCLAKYSeDGKWCRALIDNvyepVEMVEVTYVDYGNKELVSLKNLRSISEE---FLKLKAQAFRCSLYNL 74

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 53.99 E-value: 2.45e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  493 VEFVKNPSEFWIRL--RKHNVTFSKLMRRMCGFYSSASKLDGVVLkPE----PDDLCCVKWKEN-GYYRAIVTK-LDDKS 564
Cdd:cd20419     2 VEYIESPSQFYVRFysKDTSEMLEDMMIEMRRCYSNEHVSERYVM-PEafiqPGQVCCVRIPEDvWWYRVIIHQvLNKQE 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 270132304  565 VDVFLVDRGNSENVDWYDVRMLLPQFRQLPILAVKCTL 602
Cdd:cd20419    81 VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 54.30 E-value: 2.46e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1309 VYVSHINDLSDFYVQLIEDEA--EISHLSERLNSVKTRPEYYVGPPLQRGDMICAVFPEDNLWYRAVIKEQQPND-LLSV 1385
Cdd:cd20408     1 GTVTEFKNPGEFYIQIYTLEVleSLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQkKAGV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 270132304 1386 QFIDYGNVSVVHTNKIGRLDLVNAILPGLCIHCSLQGFEVPDN 1428
Cdd:cd20408    81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSG 123

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 54.81 E-value: 2.60e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1310 YVSHINDLSDFYVQLIEDEaeISHLSERLNSVKTR--------PEYYVGPPlqrgdmiCAV-FPEDNLWYRAVIKEQQpN 1380
Cdd:cd20426     4 YATAVDSPEYFWCQFATEK--IQCLAVKVQEAGEQvadrgnfiPSIYVGDP-------CIVkYSEDNHWYRALVTKIN-D 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 270132304 1381 DLLSVQFIDYGNVSVVHTNKIGRLDLVNAILPGLCIHCSLQGFEVPDNKNSKKMMHYFSQRTSE 1444
Cdd:cd20426    74 NLVSVRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYFYEIVTE 137

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 53.21 E-value: 3.45e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  997 DPWTFYCQLARNANILEQLSCSITQLSKVLLNLKTSPLNPGTLCLAKYT-DGNWYRGIVIEKEPKKVF---FVDFGNIYV 1072
Cdd:cd20441     1 SPSRFFIQLSEDEKVILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDeDLALYRAVITAVLPGKSFkveFIDYGNTAV 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 270132304 1073 VTSDDLLPIPSdayDVLLLPMQAVRCSLSDI 1103
Cdd:cd20441    81 VDKSNIYTLQE---KFLSLPRLSIPCSLSGV 108

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 54.02 E-value: 4.13e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1310 YVSHINDLSDFYVQLIEDEAEISHLSERLNSV--KTRPEYYVGPPLQRGDMICAVFPEDNLWYRAVIKEQqpNDL-LSVQ 1386
Cdd:cd20438    10 FVEYVLNPSNFWIRTDEYNNEFQALMKNIADIynLCGNDEELLKKPEPGLLCCARYSKDRHYYRAVITEV--LDLkVSVY 87

                          90       100       110
                  ....*....|....*....|....*....|....
gi 270132304 1387 FIDYGNVSVVHTNKIGRLDLVNAILPGLCIHCSL 1420
Cdd:cd20438    88 FLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSL 121

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 52.82 E-value: 4.75e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  498 NPSEFWIRLRKHNVTFSKLMRRMcgfYSSASKLDGVVL-KPEPDDLCCVKWKENG-YYRAIVTK-LDDKSVDVFLVDRGN 574
Cdd:cd20441     1 SPSRFFIQLSEDEKVILQLAEEL---NETSEKSRENAAvKLKVGDLVAAEYDEDLaLYRAVITAvLPGKSFKVEFIDYGN 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 270132304  575 SENVDWYDVRMLLPQFRQLPILAVKCTLADI 605
Cdd:cd20441    78 TAVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 52.80 E-value: 5.60e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1036 PGTLCLAKYTDGNWYRGIVI---EKEPKKVF--FVDFGNIYVVTSDDLLPIPSdayDVLLLPMQAVRCSL 1100
Cdd:cd20418     6 PEMPCLAEYSDGKWYRAKLLsilEFNPVKILvrHVDYGSTAALPTSRLRQIPA---ELMQYPCQAIKVKL 72

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 52.83 E-value: 5.64e-08

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 270132304  317 CASCGLDGHWYRALLLETfrPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYG 380
Cdd:cd20411    55 CARFTGDKNWYRAVVLET--SDSEVKVLYADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 52.45 E-value: 8.47e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  491 AQVEFVKNPSEFWIRLRKHNVTFSKLMRRMCGF--YSSASKlDGVVLKPEPDDLCCVKWK-ENGYYRAIVTKLDDKSVDV 567
Cdd:cd20411     1 ALVLEVISPDLFYALPKTGQVNVEKLKALMTELaeYCSKQS-VPQQFRPRIGDACCARFTgDKNWYRAVVLETSDSEVKV 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 270132304  568 FLVDRGNSENVDWYDVRMLLPQFRQLPILAVKCTLA 603
Cdd:cd20411    80 LYADYGNTETLPLSRILPITKSHLELPFQIIRCSLA 115

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 50.35 E-value: 8.68e-08

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 270132304    541 DLCCVKWKENGYYRAIVTKLD-DKSVDVFLVDRGNSENVDWYDVRmLLPQFR 591
Cdd:smart00333    7 DKVAARWEDGEWYRARIVKVDgEQLYEVFFIDYGNEEVVPPSDLR-QLPEEL 57

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 50.21 E-value: 1.02e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 270132304  313 PGSPCASC-GLDGHWYRALLLETFRPQRCaQVLHVDYGRKELVSCSSLRYL 362
Cdd:cd20379     1 VGDLCAAKyEEDGKWYRARVLEVLSNDKV-EVFFVDYGNTETVPLSDLRPL 50

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 50.53 E-value: 1.53e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1322 VQLIEDEAEishLSERLNSVKTRPEYYVGPplqrGDMICAVFPEDNLWYRAVIKEQQPNDLLSVQFIDYGNVSVVHTNKI 1401
Cdd:cd20409     2 RQLAELQES---LSAYCKVAPASSDFSPAV----GEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRL 74

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 52.13 E-value: 1.69e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  775 EVRVSYVENPGYFWCQLTRNIQGLKTLMSDI-QYYCKNTA------APhQRNTLAClAKRTVNRQWsRALISGIQSvEHV 847
Cdd:cd20422     3 DAQVEFVKDPSEFWIRLGEHAVPFSKLMRSMtAFYSQASKldgvvlKP-QPGQLCC-AKWKEDRYY-RAIVTAVKG-KMV 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 270132304  848 NVTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSLYNlIQPVGQNpfvWDVKAIQAF 906
Cdd:cd20422    79 EVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLAD-ICPLGER---WSPEAISAF 133

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 51.68 E-value: 1.99e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1310 YVSHINDLSDFYVQLI-EDEAEI--------------SHLSERLnsvkTRPEYYVGPplqrGDMICAVFPEDNLWYRAVI 1374
Cdd:cd20419     1 FVEYIESPSQFYVRFYsKDTSEMledmmiemrrcysnEHVSERY----VMPEAFIQP----GQVCCVRIPEDVWWYRVII 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 270132304 1375 KEQQPNDLLSVQFIDYGNVSVVHTNKIGRLDLVNAILPGLCIHCSL 1420
Cdd:cd20419    73 HQVLNKQEVEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 51.66 E-value: 2.50e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  493 VEFVKNPSEFWIRLRKHNVTFSKLMRRMCGFYSSASKLDGVVLKPEPDDLCCVKWKENGYYRAIVTKL--DDKSVDVFLV 570
Cdd:cd20421    17 VTEVTDPHRIFCQLRSLSQELKRLSESMHQYYEGRVGSGYETRPEKLGSPCAARGSDGRWYRAVLQQVfsANRVVEVLHV 96

                          90       100       110
                  ....*....|....*....|....*....|..
gi 270132304  571 DRGNSENVDWYDVRMLLPQFRQLPILAVKCTL 602
Cdd:cd20421    97 DYGRKEVVSVSNLRYLAPEYFRMPVVTYPCAL 128

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 50.13 E-value: 3.58e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 270132304 1565 IPCPYIGDPCIVRYrEDGHYYRALITNICEDYLVSVRLVDFGNIEDcVDPKALWAIPSELLSVPMQAFPCCLS 1637
Cdd:cd20415    22 ILCPVQGQACVALF-EDGAWYRARIIGLPGHREVEVKYVDFGNTAT-VTIKHVRKIKDDFLSLPEKARECRLA 92

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 50.13 E-value: 3.83e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  516 LMRRMCGFYSSASKLDGVVLKPEPDDLCCVKWKENGYYRA-IVTKLDDKSVDVFLVDRGNSENVDWYDVRMLLPQFRQLP 594
Cdd:cd20415     4 LTKKIQEFYKEGDDGGLEILCPVQGQACVALFEDGAWYRArIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLP 83

                          90
                  ....*....|...
gi 270132304  595 ILAVKCTLADIWP 607
Cdd:cd20415    84 EKARECRLAFIEP 96

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 51.10 E-value: 4.29e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  498 NPSEFWIRLRKHN-----------VTFSKLMRRMCGFYSSASKLDGVVlKPEPDDLCCVKWKENGYYRAIVTKLDDKS-- 564
Cdd:cd20435     1 DATHYSARILEHRssdgevtksmsSTYLKLSMKLNMYYSDPSNRILHG-KVKVGDLCAVEDENNLYHRVKVLEITEKDdk 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 270132304  565 -----VDVFLVDRGNSENVDWYDVRMLLPQFRQLPILAV 598
Cdd:cd20435    80 tkpreVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAV 118

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 50.18 E-value: 6.29e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1296 FPQKTIMPGFKTTVYVSHINDLSDFYVQLIEDEAEISHLSERLNSvktrpeYYV--GPPLQRGDMIC-AVFPEDNLWYRA 1372
Cdd:cd20439     1 YKEYLFKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSLMKQIQS------YYLihNDPYKHGQIACvAKYSKDGKWYRA 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 270132304 1373 VIKEQQPNDLLSVQFIDYGNvsvvhTNKIGRLDLvNAILP------GLCIHCSLQGF 1423
Cdd:cd20439    75 AVLKQVSAKEVDVIFVDYGN-----QERVLISDL-RAIKPqfllleGQAFRCSLNNF 125

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 50.18 E-value: 6.80e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  246 LQLGVTEAVVITQVCHPHRIHCQLRSVSQEIHRLSESMAQVYrgstgtgdenstsatweEREESPDKPG-SPC-ASCGLD 323
Cdd:cd20439     6 FKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSLMKQIQSYY-----------------LIHNDPYKHGqIACvAKYSKD 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 270132304  324 GHWYRALLLeTFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGL 381
Cdd:cd20439    69 GKWYRAAVL-KQVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 50.20 E-value: 7.73e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1524 YATVIDGPEYFWCQFAdteklQCLEVEVQTAGE--QVADRRNCIPCPYI-GDPCIVRYrEDGHYYRALITNICEDylVSV 1600
Cdd:cd20424    17 YITYVNDPWTFYCQLA-----RNAGVLDQLASAisRLSSEIRKLELSVNpGTLCLAKY-SDQHWYRGIIITNKNS--TEV 88

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 270132304 1601 RLVDFGNIEdCVDPKALWAIPS---ELLSVPMQAFPCCL 1636
Cdd:cd20424    89 FFVDYGNTE-KVEKEDMLPIPSdayELLLLPMQAIKCSL 126

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 50.15 E-value: 8.18e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  493 VEFVKNPSEFWIRLRKHNVTFSKLMRRMcgfySSASKL-DGVVLKPEPDDLCCVKWKENG-YYRAIVTKLDDKS-VDVFL 569
Cdd:cd20440    16 ITHVYSPAKFYCQLDRNTEILEALMEKI----AEISKLfNSQILDNCKTRLCLAKYFEDGqWYRALAHPVESSShLSVYF 91

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 270132304  570 VDRGNSENVDWYDVRMLLPQFRQL---PILAVKCTL 602
Cdd:cd20440    92 VDYGNKQIVEKNEVLPIPDTAVDLlltPMQAIKCCL 127

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 48.83 E-value: 9.06e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 270132304 1353 LQRGDMICAVFPEDNLWYRAVIKEQQPNDLLSVQFIDYGNVSVVHTNKIGRL--DLVNaiLPGLCIHCS 1419
Cdd:cd20412    29 VQVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALrsDFLS--LPFQAIECS 95

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 50.14 E-value: 9.78e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1568 PYIGDPCIVRYRedGHYYRALITNICEDYLVSVRLVDFGNIEDcVDPKALWAIPS----ELLSVPMQAFPCCLSGFNISE 1643
Cdd:cd20428    52 PFCGKICLARYK--GKWARVEITNVHSSRALDVHFLDTGTVAS-VKVSELREIPPpflrELISIPPQALKCCLADLPLNI 128


                  ....*.
gi 270132304 1644 GLCSQE 1649
Cdd:cd20428   129 GMWTPD 134

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 49.82 E-value: 1.13e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 270132304 1568 PYIGDPCIVRYREDGhYYRALITNIcEDYLVSVRLVDFGNIE--DCVDPKALwaiPSELLSVPMQAFPCCLS 1637
Cdd:cd20422    50 PQPGQLCCAKWKEDR-YYRAIVTAV-KGKMVEVFLVDRGNTEmvDWYDVKKL---LPQFRELPALALKCCLA 116

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 49.34 E-value: 1.18e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1530 GPEYFWCQFADTEK-LQCLEVEVQTAGEQVaDRRNCIPCPYIGDPCIVRyREDGHYYRALITNICEDYLVSVRLVDFGNI 1608
Cdd:cd20437    14 SPSKFYCQLLSWEPeLSKLTTQMTLHYESV-SKELNPSCENFGLLCAAK-GKDGQWHRGFLQQLLPPSQVKVWFIDYGNS 91

                          90       100
                  ....*....|....*....|....*....
gi 270132304 1609 EdCVDPKALWAIPSELLSVPMQAFPCCLS 1637
Cdd:cd20437    92 E-AVSSHSVLKLPPDFFSLPLMSFPCSLS 119

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 48.07 E-value: 1.24e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 270132304  818 RNTLaCLAKRTVNRQWSRALISGIQSVEHVNVTFVDYGDREMVSVKNIYSISEEF 872
Cdd:cd20433    30 KGDL-CAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALPPAF 83

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 49.78 E-value: 1.28e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  778 VSYVENPGYFW---CQLTRNIQGLKTLMSDIQYYCKNTAAPHQRNT--LACLAKRTVNRQWSRALISGIQSVeHVNVTFV 852
Cdd:cd20438    11 VEYVLNPSNFWirtDEYNNEFQALMKNIADIYNLCGNDEELLKKPEpgLLCCARYSKDRHYYRAVITEVLDL-KVSVYFL 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 270132304  853 DYGDREMVSVKNIYSISEEFLKVKAQAFRCSLYNlIQPVGQnpfVWDVKAIQAF 906
Cdd:cd20438    90 DFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAH-VFPVEE---VWTKNANDFF 139

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 50.04 E-value: 1.39e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  988 ELVYITHIDDPWTFYCQLARNANILEQLSCSITQLSKVLLNLKTSPLNPGTLCLAKYTDGN-WYRGIVIEKEPKK----V 1062
Cdd:cd20442     4 EKGTLLSVSKNGTFYVRLLRNSEQLTDLESLIAKEAKKCKFVPVEDIKEGLECLAKSKKNLkWYRAVVEHLYPETekmlV 83

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 270132304 1063 FFVDFGnIYVVTSddLLPIPSDAYDVLLLPMQAVRC 1098
Cdd:cd20442    84 FFVDHG-ITEVVS--MGNIKQLSNDLLQIPRQAVLC 116

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 49.39 E-value: 1.88e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  982 MKIGSEELVYITHIDDPWTFYCQLARNANILEQLSCSITQL------SKVLLNlktSPlNPGTLCLAKYT-DGNWYRGIV 1054
Cdd:cd20438     1 MEVDAAYVAFVEYVLNPSNFWIRTDEYNNEFQALMKNIADIynlcgnDEELLK---KP-EPGLLCCARYSkDRHYYRAVI 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 270132304 1055 IEKEPKK--VFFVDFGNIYVVTSDD---LLPIPSDaydvllLPMQAVRCSLSDI 1103
Cdd:cd20438    77 TEVLDLKvsVYFLDFGNTDTVPFYDvktLLPEFSE------LPALAMCCSLAHV 124

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 48.17 E-value: 2.30e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 270132304 1570 IGDPCIVRYReDGHYYRALITNICEDYLVS--VRLVDFGNiEDCVDPKALWAIPSELLSVPMQAFPCCLSGF 1639
Cdd:cd20418     6 PEMPCLAEYS-DGKWYRAKLLSILEFNPVKilVRHVDYGS-TAALPTSRLRQIPAELMQYPCQAIKVKLAGF 75

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 48.79 E-value: 2.48e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1559 ADRRNCIPC--PYIGDPCIVRYREDGhYYRALITNI--CED----YLVSVRLVDFGNIEDCVDPKaLWAIPSELLSVPMQ 1630
Cdd:cd20435    39 SDPSNRILHgkVKVGDLCAVEDENNL-YHRVKVLEIteKDDktkpREVLVKFIDEGRVETVVVSQ-LLELPEELKSLPPQ 116


                  ....*....
gi 270132304 1631 A---FPCCL 1636
Cdd:cd20435   117 AvevFLCNV 125

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 48.65 E-value: 2.72e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  490 DAQVEFVKNPSEFWIRLRKHNVTFSKLMrrmcgfySSASKLDGVVLKPE----PDDLCCVKWKENGYYRAIVTKLDDKsV 565
Cdd:cd20424    15 EVYITYVNDPWTFYCQLARNAGVLDQLA-------SAISRLSSEIRKLElsvnPGTLCLAKYSDQHWYRGIIITNKNS-T 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 270132304  566 DVFLVDRGNSENVDWYDvrmLLP------QFRQLPILAVKCTL 602
Cdd:cd20424    87 EVFFVDYGNTEKVEKED---MLPipsdayELLLLPMQAIKCSL 126

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 47.29 E-value: 2.92e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  515 KLMRRMCGFYSSASKLD--------GVVLKPEPDDlccvkwkeNGYYRA-IVTKLDDKSVDVFLVDRGNSENVDWYDVRM 585
Cdd:cd20412     8 KLVQEMTQYYESEENRHtlltvqvgDIVAAPFRHD--------GSWYRArVLGFLENGNLDLYFVDYGDSGYVPLEDLRA 79

                          90
                  ....*....|....*
gi 270132304  586 LLPQFRQLPILAVKC 600
Cdd:cd20412    80 LRSDFLSLPFQAIEC 94

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 47.07 E-value: 2.92e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 270132304 1022 LSKVLLNLKTSPLNP------GTLCLAKYTDGN-WYRGIVIEKEPKK---VFFVDFGNIYVVTSDDLLPIPS 1083
Cdd:cd20409     8 QESLSAYCKVAPASSdfspavGEVCCAQFTEDNqWYRASVLAYSSEDsvlVGYIDFGNSEEVALSRLRPIPP 79

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 47.29 E-value: 2.98e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 270132304 1568 PYIGDPCIVRYREDGHYYRALITNICEDYLVSVRLVDFGNIEDcVDPKALWAIPSELLSVPMQAFPC 1634
Cdd:cd20412    29 VQVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGY-VPLEDLRALRSDFLSLPFQAIEC 94

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 48.57 E-value: 3.08e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1526 TVIDGPEYFWCQfadtekLQCLEVEVQTAGEQVAD-------RRNCIPCPYIGDPCIVRyREDGHYYRALITN-ICEDYL 1597
Cdd:cd20421    18 TEVTDPHRIFCQ------LRSLSQELKRLSESMHQyyegrvgSGYETRPEKLGSPCAAR-GSDGRWYRAVLQQvFSANRV 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 270132304 1598 VSVRLVDFGNiEDCVDPKALWAIPSELLSVPMQAFPCCLSG 1638
Cdd:cd20421    91 VEVLHVDYGR-KEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410455 Cd Length: 55 Bit Score: 46.06 E-value: 3.27e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 270132304 1032 SPLNPGTLCLAKYTDGNWYRGIVIEKEPKKVFFVDF---GNIYVVTSDDLLPI 1081
Cdd:cd20384     3 SSLKEGSRCLAKYDDGLWYPATVTDIDEDGKYTVKFdsyGEVAVVELDDILPL 55

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 47.84 E-value: 3.68e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  774 VEVRVSYVENPGYFWCQLTRNiQGLKTLMSDI---------QYYCKntaaPHQRNTLAClAKRTVNRQWSRALISGIQSV 844
Cdd:cd20425     2 TEVYVSHVNSPSDFYVQLAQD-EDELSMISEKlnaskandeEVECE----SLQLGDLIC-AEYPEDGLWYRAVVKEKIPN 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 270132304  845 EHVNVTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSL 884
Cdd:cd20425    76 NLVSVQFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 47.88 E-value: 5.04e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  241 YFYPQ--LQLGVTEAVVITQVCHPHRIHCQLRSVSQEIHRLSESMAQVyrgstgtgdenSTSATweeREESPDKPGSPCA 318
Cdd:cd20424     1 YYYSMhdIKIGSEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRL-----------SSEIR---KLELSVNPGTLCL 66

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 270132304  319 SCGLDGHWYRALLLETFRPQrcaQVLHVDYGRKELV 354
Cdd:cd20424    67 AKYSDQHWYRGIIITNKNST---EVFFVDYGNTEKV 99

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 47.36 E-value: 6.22e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  254 VVITQVCHPHR--IHCQLRSVSQEIHRLSESMAQVYrgstgtgdenstSATWEEREESPDKpGSPC-ASCGLDGHWYRAL 330
Cdd:cd20408     1 GTVTEFKNPGEfyIQIYTLEVLESLVKLTSQLKKTY------------ASVNNHKEYIPEV-GEVCvAKYSEDQNWYRAL 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 270132304  331 LLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGLWDGGRGWS 389
Cdd:cd20408    68 VQTVDVQQKKAGVFYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWS 126

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 47.06 E-value: 8.05e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  778 VSYVENPGYFWCQLTRNIQG--LKTLMSDIQYYCKNT------AAPHQ--RNTLACLAKRTVNRQWSRALISGIQSVEHV 847
Cdd:cd20419     2 VEYIESPSQFYVRFYSKDTSemLEDMMIEMRRCYSNEhvseryVMPEAfiQPGQVCCVRIPEDVWWYRVIIHQVLNKQEV 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 270132304  848 NVTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSL 884
Cdd:cd20419    82 EVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 46.73 E-value: 9.53e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1304 GFKTTVYVSHINDLSDFYVQLIEDEAEISHLS---ERLNSVKTRPEYYVGPplqrGDMICAVFpEDNLWYRAVIKEQQPN 1380
Cdd:cd20424    11 GSEEEVYITYVNDPWTFYCQLARNAGVLDQLAsaiSRLSSEIRKLELSVNP----GTLCLAKY-SDQHWYRGIIITNKNS 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 270132304 1381 dlLSVQFIDYGNVSVVhtNKIGRLDLVN-----AILPGLCIHCSL 1420
Cdd:cd20424    86 --TEVFFVDYGNTEKV--EKEDMLPIPSdayelLLLPMQAIKCSL 126

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 44.89 E-value: 1.37e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 270132304 1031 TSPLNPGTLCLAkYTDGNWYRGIVIE--KEPKKVF--FVDFGNIYVVTSDDLLPIPSDaydVLLLPMQAVRCSLSDI 1103
Cdd:cd20407     2 PEPIEVGVICAA-PVMNAWYRAQVVGvfEETDEVEikYLDYGGYERVPVDDLRQIRSD---FMTLPFQATECYLANI 74

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 45.50 E-value: 1.44e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 270132304  822 ACLAKRTvNRQWSRALISGIQSVEHVNVTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSL 884
Cdd:cd20415    30 ACVALFE-DGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRL 91

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 45.89 E-value: 1.47e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 270132304  835 RALISGIQSVEHVNVTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSL 884
Cdd:cd20441    56 RAVITAVLPGKSFKVEFIDYGNTAVVDKSNIYTLQEKFLSLPRLSIPCSL 105

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 43.87 E-value: 1.79e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 270132304  536 KPEPDDLCCVKWKENG-YYRAIVTK-LDDKSVDVFLVDRGNSENVDWYDVRMLLPQF 590
Cdd:cd20410     2 KPIVGEPCCAFFSGDGnWYRAMVKEiLPGGAVKVHFVDYGNVEEVTLDKLRKITSTF 58

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 46.28 E-value: 2.02e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  990 VYITHIDDPWTFYCQ-----LARNANILEQL-----SCSITqlSKVLLNLKTSplnpGTLCLAKYTdGNWYRGIVIEKEP 1059
Cdd:cd20428     4 VRVTNVCSDGTLYCQvpskgLSKLNEILDKIeyyfhSRQMT--SEYFVSLPFC----GKICLARYK-GKWARVEITNVHS 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 270132304 1060 KK---VFFVDFGNIYVVTSDDLLPIPSD-AYDVLLLPMQAVRCSLSDIPDHI---PEEVVVW 1114
Cdd:cd20428    77 SRaldVHFLDTGTVASVKVSELREIPPPfLRELISIPPQALKCCLADLPLNIgmwTPDAVLW 138

first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the first/N-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410505 Cd Length: 164 Bit Score: 46.65 E-value: 2.18e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  496 VKNPSEFWIRLRK-------HNVTFSKLMRRMCGFYSSaSKLDGVVLKP---EPDDLCCVKWKE-NGYYRAIVTKL---- 560
Cdd:cd20434     6 IEDPGCFWGRILKgsgdlvvNPEEYENLQDEMNQFYHK-GYKDVEEIKPstlEEGQVCVVFCEElKCWCRAVVESLmssa 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 270132304  561 DDKSVDVFLVDRGNSENVDWYDVRMLLPQFRQLPILAVKCTLADIWPL---------------GKTWSQEAVSFFKKTV 624
Cdd:cd20434    85 DDYLAECFLVDYAKYIPVKSKDIRVALEAFMKLPYRAKKFRLYGIKPVtlhvdlcedkakivpARKWDSAAIQYFQNLL 163

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410470 [Multi-domain] Cd Length: 55 Bit Score: 43.45 E-value: 2.38e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 270132304 1570 IGDPCIVRYREDGHYYRALITNICEDYLVSVRLVDFGNIEDC 1611
Cdd:cd20399     3 VGDKCMAVWSEDGQYYEATIEEISEDGTCTVTFDGYGNTEVT 44

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 45.52 E-value: 2.45e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1524 YATVIDGPEYFWCQFA---DTEKLQCLEVEVQT--AGEQVADRRNCIPCpYI--GDPCIVRYREDGHYYRALITNICEDY 1596
Cdd:cd20419     1 FVEYIESPSQFYVRFYskdTSEMLEDMMIEMRRcySNEHVSERYVMPEA-FIqpGQVCCVRIPEDVWWYRVIIHQVLNKQ 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 270132304 1597 LVSVRLVDFGNIEdCVDPKALWAIPSELLSVPMQAFPCCL 1636
Cdd:cd20419    80 EVEVFYPDFGDIG-TVQKSRLRFLKCCYSKLPAQAIPASL 118

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 44.39 E-value: 2.80e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 270132304 1352 PLQRGDMIC-AVFPEDNLWYRAVIKE-QQPNDLLSVQFIDYGNVSVVHTNKIGRLDLVNAILPGLCIHCSLQGFEVP 1426
Cdd:cd20423     1 PHSLPNPVClAKYSEDGKWCRALIDNvYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQP 77

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 45.90 E-value: 2.82e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  776 VRVSYVENPGYFWCQL-TRNIQGLKTLMSDIQYYCKntaapHQRNTLACLAKRTV---------NRQWSRALISGIQSVE 845
Cdd:cd20428     4 VRVTNVCSDGTLYCQVpSKGLSKLNEILDKIEYYFH-----SRQMTSEYFVSLPFcgkiclaryKGKWARVEITNVHSSR 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 270132304  846 HVNVTFVDYGDREMVSVKNIYSISEEFLK----VKAQAFRCSLYNLIQPVGqnpfVWDVKAIQ 904
Cdd:cd20428    79 ALDVHFLDTGTVASVKVSELREIPPPFLRelisIPPQALKCCLADLPLNIG----MWTPDAVL 137

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 44.21 E-value: 2.92e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 270132304 1571 GDPCIVRYREDGHYYRALITNICEDYLVSVRLVDFGNIEDcVDPKALWAIPSEL 1624
Cdd:cd20433    31 GDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREV-LPSTRLAALPPAF 83

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 43.82 E-value: 3.00e-05

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 270132304 1361 AVFPEDNLWYRAVIKEQQPNDLLSVQFIDYGNVSVV 1396
Cdd:cd20430    27 GKFSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETV 62

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 43.98 E-value: 3.25e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 270132304  801 LMSDIQYYCKNTAA-PHQRNTL--ACLAKRTVNRQWSRALISGIQSVEHVNVTFVDYGDREMVSVKNIYSISEEFL 873
Cdd:cd20409     7 LQESLSAYCKVAPAsSDFSPAVgeVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPSLL 82

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 44.71 E-value: 3.65e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 270132304  313 PGSPCASCGLDGHWYRALLL--ETFRPQRCAqVLHVDYGRKELVSCSSLRYLLPEYFRmpvvtYPCAL 378
Cdd:cd20418     6 PEMPCLAEYSDGKWYRAKLLsiLEFNPVKIL-VRHVDYGSTAALPTSRLRQIPAELMQ-----YPCQA 67

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 44.37 E-value: 5.72e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  491 AQVEFVKNPSEFWIRLRKHNVTFSKLmrrmcgfyssASKLDGVVLKPEP--------DDLCCVKWKENG-YYRAIVT-KL 560
Cdd:cd20425     4 VYVSHVNSPSDFYVQLAQDEDELSMI----------SEKLNASKANDEEveceslqlGDLICAEYPEDGlWYRAVVKeKI 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 270132304  561 DDKSVDVFLVDRGNSENVDWYDVRMLLPQFRQLPILAVKCTL 602
Cdd:cd20425    74 PNNLVSVQFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 42.41 E-value: 5.73e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 270132304 1039 LCLAKYTDgNWYRGIVIEKEPK---KVFFVDFGNIYVVTSDDLLPIPSD 1084
Cdd:cd20445     4 LCIAKYMD-KWYRAVCLESVGDgrpTVLFCDYGNILMARLTDIRPFPPT 51

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 44.81 E-value: 5.89e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  312 KPGSPCASCGLDGHWYRALLLETfrPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGLWDGGRGWSRS 391
Cdd:cd20422    51 QPGQLCCAKWKEDRYYRAIVTAV--KGKMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPE 128


                  ....*.
gi 270132304  392 QVGDLK 397
Cdd:cd20422   129 AISAFK 134

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 43.44 E-value: 7.02e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 270132304  833 WSRALISGIQSVEHVNVTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCS 883
Cdd:cd20412    45 WYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALRSDFLSLPFQAIECS 95

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 45.03 E-value: 7.79e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 270132304  543 CCVKWKENG-YYRAIVTKL--DDKSVDVFLVDRGNSENVDWYDVRMLLPQFRQLPILAVKCTLadIWP 607
Cdd:cd20442    56 CLAKSKKNLkWYRAVVEHLypETEKMLVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLCRW--NWP 121

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 44.42 E-value: 8.91e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1309 VYVSHINDLSDFYVQLIEDEAEISHLSERLNSVKTRPEYYVGPPL--QRGDMICAVFpEDNLWYRAVIKEQQpNDLLSVQ 1386
Cdd:cd20422     4 AQVEFVKDPSEFWIRLGEHAVPFSKLMRSMTAFYSQASKLDGVVLkpQPGQLCCAKW-KEDRYYRAIVTAVK-GKMVEVF 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 270132304 1387 FIDYGNVSVVHTNKIGRLDLVNAILPGLCIHCSLQGFEVPDNKNSKKMMHYF 1438
Cdd:cd20422    82 LVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAF 133

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 44.41 E-value: 9.90e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  315 SPCASCG--------LDGHWYRALLLETfrPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGlWDGGR 386
Cdd:cd20426    44 IPSIYVGdpcivkysEDNHWYRALVTKI--NDNLVSVRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSG-FNLSE 120

                          90
                  ....*....|....*
gi 270132304  387 G-WSRSQVGDLKTLI 400
Cdd:cd20426   121 GlWSDEANDYFYEIV 135

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 41.47 E-value: 1.12e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 270132304 1571 GDPCIVRYREDGHYYRALITNI-CEDYLVSVRLVDFGNIEDcVDPKALWAI 1620
Cdd:cd21182     1 GDKCLAPYSDDGKYYEATIEEItEESDTATVVFDGYGNSEE-VPLSDLKPL 50

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 41.52 E-value: 1.20e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 270132304 1036 PGTLCLAKYtDGNWYRGIVIE---KEPK-KVFFVDFGNIYVVTSDDLLPIPSD 1084
Cdd:cd20444     3 PGQMVIAKF-DGNHYRAIVLRvlnPDLKiLVRFVDFGNVEVMKLENLYECPEY 54

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 42.47 E-value: 1.27e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 270132304  539 PDDLCCVKWKENG-YYRAIVTKLDD--KSVDVFLVDRGNSENVDWYDVRMLLPQFRQLPILAVKCTLADIWP 607
Cdd:cd20423     5 PNPVCLAKYSEDGkWCRALIDNVYEpvEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQ 76

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 42.67 E-value: 1.35e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 270132304 1045 TDGNWYRGIVI---EKEPKKVFFVDFGNIYVVTSDDLLPIPSDaydVLLLPMQAVRCS 1099
Cdd:cd20412    41 HDGSWYRARVLgflENGNLDLYFVDYGDSGYVPLEDLRALRSD---FLSLPFQAIECS 95

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 41.90 E-value: 1.70e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 270132304  322 LDGHWYRALLlETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYF 367
Cdd:cd20433    40 EDGEWYRAKV-EKVEGDKKVHVLYIDYGNREVLPSTRLAALPPAFS 84

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 41.17 E-value: 1.90e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 270132304  823 CLAKRTVNRQWSRALISGIQSVEHVNVTFVDYGDREMVSVKNIYSISEEFL 873
Cdd:cd20410     9 CCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 41.17 E-value: 1.99e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 270132304  312 KPGSPCasCGL---DGHWYRALLLETFRPQrCAQVLHVDYGRKELVSCSSLRYLLPEY 366
Cdd:cd20410     4 IVGEPC--CAFfsgDGNWYRAMVKEILPGG-AVKVHFVDYGNVEEVTLDKLRKITSTF 58

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 40.65 E-value: 2.21e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 270132304 1037 GTLCLAKYT-DGNWYRGIVIEKEPKKVFFVDF--GNIYVVTSDDLLP 1080
Cdd:cd04508     1 GDRVEAKWSdDGQWYPATVVAVNDDGKYTVLFddGNEEEVSEDDIRP 47

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410500 Cd Length: 91 Bit Score: 42.09 E-value: 2.41e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  516 LMRRMCGFYSsasKLDGVVLKPEPDDLCCVKwKENGYYRAIVTK-LDDKSVDVFLVDRGNSENVDWYDVRMLLPQFRQLP 594
Cdd:cd20429    12 LMEEMILYYN---KTEERPVAIEKNKVYAAK-IENNWYRVLVKGiLTNGLVSVYELDYGKHELVSIRKVQPLIEKFRQLP 87


                  ....
gi 270132304  595 ILAV 598
Cdd:cd20429    88 FQAI 91

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 40.72 E-value: 2.64e-04

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 270132304    822 ACLAkRTVNRQWSRALISGIQSVEHVNVTFVDYGDREMVSVKNIYSISEEF 872
Cdd:smart00333    8 KVAA-RWEDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57

first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the first/N-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410505 Cd Length: 164 Bit Score: 43.57 E-value: 2.75e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  776 VRVSYVENPGYFWCQLTR----------NIQGLKTLMSDI-QYYCKNTaaphQRNTLACLAKRTVN-------RQWSRAL 837
Cdd:cd20434     1 IQVLKIEDPGCFWGRILKgsgdlvvnpeEYENLQDEMNQFyHKGYKDV----EEIKPSTLEEGQVCvvfceelKCWCRAV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  838 ISGI-QSVEH--VNVTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSLYNlIQPVG-QNPFV-----------WDVKA 902
Cdd:cd20434    77 VESLmSSADDylAECFLVDYAKYIPVKSKDIRVALEAFMKLPYRAKKFRLYG-IKPVTlHVDLCedkakivparkWDSAA 155


                  ....*
gi 270132304  903 IQAFN 907
Cdd:cd20434   156 IQYFQ 160

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 42.43 E-value: 2.97e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 270132304 1356 GDMICAVFPEDNLWYRAVIKEQQPNDlLSVQFIDYGNVSVVHTNKIGRLDLVNAILPGLCIHCSLQG 1422
Cdd:cd20411    51 GDACCARFTGDKNWYRAVVLETSDSE-VKVLYADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410500 Cd Length: 91 Bit Score: 41.32 E-value: 3.39e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  790 QLTRNIQGLKTLMSD-IQYYCKN--TAAPHQRNTLaCLAKrtVNRQWSRALISGIQSVEHVNVTFVDYGDREMVSVKNIY 866
Cdd:cd20429     1 QPWQELHKLEVLMEEmILYYNKTeeRPVAIEKNKV-YAAK--IENNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQ 77

                          90
                  ....*....|...
gi 270132304  867 SISEEFLKVKAQA 879
Cdd:cd20429    78 PLIEKFRQLPFQA 90

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 42.24 E-value: 4.63e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 270132304 1037 GTLCLAKYTDGNWYRGIVIE-------KEPKK--VFFVDFGNIYVVTSDDLLPIPSDAydvLLLPMQAV 1096
Cdd:cd20435    53 GDLCAVEDENNLYHRVKVLEitekddkTKPREvlVKFIDEGRVETVVVSQLLELPEEL---KSLPPQAV 118

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 39.98 E-value: 4.69e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 270132304 1568 PYIGDPCIVRYreDGHYYRALITNI-CEDYLVSVRLVDFGNIEdCVDPKALWAIPSEL 1624
Cdd:cd20444     1 PTPGQMVIAKF--DGNHYRAIVLRVlNPDLKILVRFVDFGNVE-VMKLENLYECPEYL 55

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 41.68 E-value: 4.76e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1534 FWCQFADTEKLQclEVEVQTAGEQVADRRNCIPC--PYIGDPCIVRYREDGHYYRALITN------ICEDYLVSVRLVDF 1605
Cdd:cd20443     4 FYVQVVSDQRLS--SIQQQLEGLSLKDKANPPGGfnPKKGELVLAQFSADNSWNRAMVVNaprqgtQSPKDEYEVFYIDY 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 270132304 1606 GNIEdCVDPKALWAIPSELLSVPMQAFPCCLSG 1638
Cdd:cd20443    82 GNQE-TVPLSALRPLDPSVSSAPGLAQLCSLAH 113

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 42.08 E-value: 5.37e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 270132304  317 CASCGLDGHWYRALLLETFRPQrcAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCAL 378
Cdd:cd20438    62 CARYSKDRHYYRAVITEVLDLK--VSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSL 121

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 41.57 E-value: 5.66e-04

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 270132304    69 PGELCLVQVGLLWHRCRV-VSRQAQESRVFLLDEGRTITAGAGSLAPGRREFFNLPSEVLGCVLAG 133
Cdd:pfam00567   52 DGCVAAFSEDGKWYRAKItESLDDGLVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 41.64 E-value: 6.76e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1308 TVYVSHINDLSDFYVQLIEDEAEISHLSERLNSV---------KTRPEYyVGPPlqrgdmiCAVFPEDNLWYRAVIKEQ- 1377
Cdd:cd20421    14 TVVVTEVTDPHRIFCQLRSLSQELKRLSESMHQYyegrvgsgyETRPEK-LGSP-------CAARGSDGRWYRAVLQQVf 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 270132304 1378 QPNDLLSVQFIDYGNVSVVHTNKIGRLDLVNAILPGLCIHCSLQG 1422
Cdd:cd20421    86 SANRVVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 39.25 E-value: 7.10e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 270132304 1571 GDPCIVRYREDGHYYRALITNICEDYLVS-VRLVDFGNIED 1610
Cdd:cd20413     4 GDECLAKYWEDNKFYRAEVTAVHPSGKTAvVKFMEYGNYEE 44

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 40.86 E-value: 7.57e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1355 RGDMICAVFPEDNLWYRA---VIKEQQPNDLLsVQFIDYGNVSVVHTNKIGRLDLVNAILPGLCIHCSLQGFEVPDNKNS 1431
Cdd:cd20418     5 RPEMPCLAEYSDGKWYRAkllSILEFNPVKIL-VRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPLNDSE 83

                          90       100
                  ....*....|....*....|.
gi 270132304 1432 KKMMHY---FSQRTSEAAIRC 1449
Cdd:cd20418    84 TERIPYcpeWSMKALWAMIDL 104

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 41.59 E-value: 7.58e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1526 TVID--GPEYFWCQFADT---EKLQCLEVEVQTAGEQVADRRNCIPCpyIGDPCIVRYREDGHYYRALITNI-CEDYLVS 1599
Cdd:cd20408     2 TVTEfkNPGEFYIQIYTLevlESLVKLTSQLKKTYASVNNHKEYIPE--VGEVCVAKYSEDQNWYRALVQTVdVQQKKAG 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 270132304 1600 VRLVDFGNiEDCVDPKALWAIPSELLSVPMQAFPCCLSG 1638
Cdd:cd20408    80 VFYIDYGN-EETVPLNRIQPLKKDIELFPPCAIKCCLAN 117

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 40.13 E-value: 8.30e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 270132304 1567 CPYIGDPCIVRYREDGHYYRALITNICEDYLVSVRLVDFGNIEDcVDPKALWAIPSELL 1625
Cdd:cd20409    25 SPAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEE-VALSRLRPIPPSLL 82

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 38.86 E-value: 9.83e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 270132304 1036 PGTLCLAKY-TDGNWYRGIVIEKEPKK----VFFVDFGNIYVVTSDDLLPI 1081
Cdd:cd20413     3 PGDECLAKYwEDNKFYRAEVTAVHPSGktavVKFMEYGNYEEVLLSDIKPI 53

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 38.72 E-value: 9.97e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 270132304 1356 GDMICAVFPEDNLWYRAVIKEQQPNDLLSVQFiDYGNVSVV 1396
Cdd:cd04508     1 GDRVEAKWSDDGQWYPATVVAVNDDGKYTVLF-DDGNEEEV 40

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 39.98 E-value: 1.04e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 270132304  515 KLMRRMCGFYSSASKLDGVVlKPEPDDLCCVKWKENG-YYRAIVTKLD-DKSVDVFLVDRGNSENVDWYDVRMLLPQF 590
Cdd:cd20433     7 KLMEKLRFEIASNPPLPGSY-TPRKGDLCAAKFVEDGeWYRAKVEKVEgDKKVHVLYIDYGNREVLPSTRLAALPPAF 83

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 39.11 E-value: 1.51e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 270132304  534 VLKPEPDDLCCVKWKENGYYRAIV--TKLDDKSVDVFLVDRGNSENVDWYDVRMLLPQFRQLPILAVKCTLADIWP 607
Cdd:cd20407     1 LPEPIEVGVICAAPVMNAWYRAQVvgVFEETDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 38.41 E-value: 1.53e-03

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 270132304    312 KPGSPCASCGLDGHWYRALLLETFRPQRCaQVLHVDYGRKELVSCSSLRyLLPE 365
Cdd:smart00333    4 KVGDKVAARWEDGEWYRARIVKVDGEQLY-EVFFIDYGNEEVVPPSDLR-QLPE 55

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 38.81 E-value: 1.73e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 270132304  801 LMSDIQYYCKN----TAAPHQRNTLAClaKRTVNRQWSRALISGIQSVEHVNVTFVDYGDREMVSVKNIYSISEEF 872
Cdd:cd20430     1 LSDELAEVCPTapplFGTPDPNKIYGG--KFSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETVSRSSIVELPPDL 74

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 39.72 E-value: 1.73e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  801 LMSD-IQYYCKNTAAPHQRNTLAC---LAKRTVNRQWSRALISGIQSvEHVNVTFVDYGDREMVSVKNIYSISEEFLKVK 876
Cdd:cd20427     2 QMEDeMKEFYSKSSTAMCLRSPSVgqlVAVKAEEDAWLRAQVIEVEE-DKVKVYYVDHGFSEVVERSKLFKLNKQFYSLP 80

                          90
                  ....*....|....*....
gi 270132304  877 AQAFRCSLYNLiQPVGQNP 895
Cdd:cd20427    81 FQATKCKLAGL-EPFSDDP 98

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 39.29 E-value: 2.46e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  779 SYVENPGYFWCQLT--RNIQGLKTLMSDI--QYYCKNTAAPHQrnTLACLA--KRTVNRQWSRALI---SGiQSVEhvnV 849
Cdd:cd20431     1 TEVVEVGHFWGYRIdeNSSEILQQLTAEInqRQLVPLTTKPVP--NLLCLApfTDADMKKYYRAKIlyvSG-SSAE---V 74

                          90       100
                  ....*....|....*....|....*.
gi 270132304  850 TFVDYGDREMVSVKNIYSISEEFLKV 875
Cdd:cd20431    75 FFVDYGNTSQVPSSLLREIPETLLTL 100

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 37.62 E-value: 2.54e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 270132304 1356 GDMICAVFPEDNLWYRAVIKE-QQPNDLLSVQFIDYGNVSVV 1396
Cdd:cd21182     1 GDKCLAPYSDDGKYYEATIEEiTEESDTATVVFDGYGNSEEV 42

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 39.35 E-value: 3.02e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 270132304 1034 LNPGTLCLAKYT-DGNWYRGI---VIEKEPKKVFFVDFGNIYVVTSDDLLPIPSDAYDvllLPMQAVRCSL 1100
Cdd:cd20419    51 IQPGQVCCVRIPeDVWWYRVIihqVLNKQEVEVFYPDFGDIGTVQKSRLRFLKCCYSK---LPAQAIPASL 118

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 40.41 E-value: 3.06e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1307 TTVYVShinDLSDFYVQLIEDEAE----ISHLSERLNSVKTRPEyyvgPPLQRGdMICAVFPEDNL-WYRAVIKEQQPND 1381
Cdd:cd20442     7 TLLSVS---KNGTFYVRLLRNSEQltdlESLIAKEAKKCKFVPV----EDIKEG-LECLAKSKKNLkWYRAVVEHLYPET 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 270132304 1382 L-LSVQFIDYGNVSVV--HTNKIGRLDLVNaiLPGLCIHCSLQGFEVP----DNKNSKKMMH 1436
Cdd:cd20442    79 EkMLVFFVDHGITEVVsmGNIKQLSNDLLQ--IPRQAVLCRWNWPESSkelsFEILWKSLAG 138

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 37.67 E-value: 3.07e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 270132304 1353 LQRGDMICAVFpeDNLWYRAVIKE-QQPNDLLSVQFIDYGNVSVVHTNKI 1401
Cdd:cd20444     1 PTPGQMVIAKF--DGNHYRAIVLRvLNPDLKILVRFVDFGNVEVMKLENL 48

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 37.27 E-value: 6.62e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 270132304 1015 LSCSITQLSKVLLNLKTSPlNPGTLCLAKYT-DGNWYRGIVIEK---EPKKVFFVDFGNIYVVTSDDLLPIPSD 1084
Cdd:cd20430     1 LSDELAEVCPTAPPLFGTP-DPNKIYGGKFSeDNCWYRCKVKSIlsdEKCTVQYIDYGNTETVSRSSIVELPPD 73

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 38.77 E-value: 6.70e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1316 DLSDFYVQLIE-----------DEAEISHLSERLNsvktrpEYYVGP-------PLQRGDmICAVFPEDNLWYRA-VIKE 1376
Cdd:cd20435     1 DATHYSARILEhrssdgevtksMSSTYLKLSMKLN------MYYSDPsnrilhgKVKVGD-LCAVEDENNLYHRVkVLEI 73

                          90       100       110
                  ....*....|....*....|....*....|
gi 270132304 1377 QQPNDLLS-----VQFIDYGNVSVVHTNKI 1401
Cdd:cd20435    74 TEKDDKTKprevlVKFIDEGRVETVVVSQL 103

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 38.94 E-value: 7.07e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1536 CQFaDTEKLQcleVEVQtageQVADRRNCIPcpyIGDPCIVRYREDGHYYRALITNIcEDYLVSVRLVDFGNIEDcVDPK 1615
Cdd:cd20436    26 CEL-DYHILQ---NEIQ----NATKSKSSWG---VGEFCLVEDTTSGEWYRGRVLEK-IDEKYEVFLIDRGEVLN-VHAT 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 270132304 1616 ALWAIPSELLSVPMQAFPCCLSGFNISEGLCSQEGNDYFYEII 1658
Cdd:cd20436    93 NMASASGELFQLPPKAVCGIFANILPIGEKWSSTAVNYFSSLI 135

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 38.94 E-value: 7.27e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304  823 CLAKRTVNRQWSRALISGIQSvEHVNVTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSLYNlIQPVGQnpfVWDVKA 902
Cdd:cd20436    53 CLVEDTTSGEWYRGRVLEKID-EKYEVFLIDRGEVLNVHATNMASASGELFQLPPKAVCGIFAN-ILPIGE---KWSSTA 127


                  ....*...
gi 270132304  903 IQAFNEFI 910
Cdd:cd20436   128 VNYFSSLI 135

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 38.94 E-value: 7.77e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270132304 1037 GTLCLAKYT-DGNWYRGIVIEKEPKK--VFFVDFGNIYVVTSDDLLPIPSdayDVLLLPMQAVRCSLSDI 1103
Cdd:cd20436    50 GEFCLVEDTtSGEWYRGRVLEKIDEKyeVFLIDRGEVLNVHATNMASASG---ELFQLPPKAVCGIFANI 116