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Conserved domains on  [gi|270265871|ref|NP_001161707|]
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FRAS1-related extracellular matrix protein 3 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Frem_N pfam19309
Frem protein N-terminal domain; This entry represents a presumed domain found at the ...
 62-269 4.04e-123

Frem protein N-terminal domain; This entry represents a presumed domain found at the N-terminus of Frem related proteins.


:

Pssm-ID: 466034  Cd Length: 202  Bit Score: 385.92  E-value: 4.04e-123
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871    62 VLIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLD--ALPRLKGALSPRRFPCTFGPRQVQYTHFGSHSPGRARV 139
Cdd:pfam19309    1 ILIANRGLRVPFGRSVWLDPLRDLVIQVQPGDRCEVTVLDndPLPQRPGALSPRRFPCDFGPREVQYTHFGSRSPSRDRV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   140 LLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEKLRSWSRAIDRRVLDFASLKSgataTRRCRLTPLPHEDGp 219
Cdd:pfam19309   81 RLQLRYDAPTDTLVLPFTLEVEVVFSQLEIVTRNLPLTVEKLLGTSNPIDRRVLEFAYDPG----TERCKVTVLPGAGG- 155

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 270265871   220 LPKYGRLVDAVGAPLPrgkgVDCEAFLRAGVRYQHTAT-SSPNRDYVPMMV 269
Cdd:pfam19309  156 LPRYGRLVNATGAPLM----VDCEAFLRAGVRYQHTATtSSPNRDYVPMVV 202
Cadherin_3 pfam16184
Cadherin-like;
416-524 9.49e-34

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 126.56  E-value: 9.49e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   416 SDPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSsTHSIPISDKDNL-EEVKMAAVRGLRHGQLVVFGAP-AGCKYF 493
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPIT-PDLLQAEDPDTPpEDLTYTVVQGPSHGHLALKGAPgLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 270265871   494 TPADLAAGRVVYQHDGSNTYSDNIIFRMEDG 524
Cdd:pfam16184   81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1524-1627 5.86e-31

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 118.47  E-value: 5.86e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1524 RTFRIFITDVDNKKPILTIHR-LTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKILYNGS--RPVTTFTKQD 1600
Cdd:pfam16184    5 FTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGApgLPVTNFTQAD 84

                           90       100
                   ....*....|....*....|....*..
gi 270265871  1601 LNKNLISYKHDGSETTEDSFSLTVTDG 1627
Cdd:pfam16184   85 IDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
812-922 2.41e-29

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 113.85  E-value: 2.41e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   812 NSVPGTFTLFLQPVDNQPPEVT-NRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGESF 890
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTtNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 270265871   891 MQADVINGSVSYQHgRDQTTTSDTFHLEVSDG 922
Cdd:pfam16184   81 TQADIDSGLVVYVH-DGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1289-1406 1.44e-28

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 111.54  E-value: 1.44e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1289 HTTHRKVPIVVTLVDDETPHLTVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRnn 1368
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVT-- 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 270265871  1369 ltlgmNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDG 1406
Cdd:pfam16184   79 -----NFTQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1182-1287 1.24e-23

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 97.67  E-value: 1.24e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1182 FPIIILPTNDEQPKLFAHE-FKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGsQPIHSFTLKEI 1260
Cdd:pfam16184    7 FNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPG-LPVTNFTQADI 85

                           90       100
                   ....*....|....*....|....*..
gi 270265871  1261 qEASTIVYEHDDSETKEDSFEVWLSDG 1287
Cdd:pfam16184   86 -DSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1409-1515 3.52e-20

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 87.66  E-value: 3.52e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1409 TLTDHYFYVTIGNLDSVFPEVISKR-ITLIEGARVTLTNNLLTNSDINSSDEH-HFSITRAPSLGHLESSDYAGEPIASF 1486
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDlTYTVVQGPSHGHLALKGAPGLPVTNF 80

                           90       100
                   ....*....|....*....|....*....
gi 270265871  1487 TQLQLASNKISYVHTsNDEKKMDSFEFQV 1515
Cdd:pfam16184   81 TQADIDSGLVVYVHD-GSESTSDGFTFQV 108
Cadherin_3 pfam16184
Cadherin-like;
1645-1757 5.73e-20

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 86.89  E-value: 5.73e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1645 PQVMRVQIRSLDNRLPQITTNRGapaLKRLHTGHmgFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTR 1724
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVLTTNTG---LRLWEGSS--RPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVT 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 270265871  1725 VFTQADIDEMKISYVlNEGSNASKDIFYFSVED 1757
Cdd:pfam16184   79 NFTQADIDSGLVVYV-HDGSESTSDGFTFQVTD 110
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1775-1987 2.29e-19

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 95.63  E-value: 2.29e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1775 ICLEKEYYIVDEDSTFLEVTLTRRGY-LGETSFISIGTKDETAKKDKDFKWkTNKQIQFNPGQTTATWRVRIIPDNEYET 1853
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGdLTNTVYVDYRTEDGTANAGSDYEF-TEGTLVFKPGETQKEFRIGIIDDDIFEE 480

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1854 SETFQIILSEP---------------LMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQEL 1918
Cdd:TIGR00845  481 DEHFYVRLSNLrvgsedgileanhvsAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTV 560

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 270265871  1919 IVICSTRQGSATGTisstvlFSDYisrpEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLP 1987
Cdd:TIGR00845  561 IVPYRTVEGTARGG------GKDF----EDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEP 619
Cadherin_3 super family cl28802
Cadherin-like;
1058-1173 7.30e-18

Cadherin-like;


The actual alignment was detected with superfamily member pfam16184:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 81.11  E-value: 7.30e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1058 VQVTVLPVDNVGPKVFVGESFIVYEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEkiasapgsKMSQSGSPIS 1137
Cdd:pfam16184    7 FNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLA--------LKGAPGLPVT 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 270265871  1138 AFSLRDIQVRHINYVqsiHKGVEPQEDQFTFYCSDG 1173
Cdd:pfam16184   79 NFTQADIDSGLVVYV---HDGSESTSDGFTFQVTDG 111
Cadherin_3 super family cl28802
Cadherin-like;
526-608 5.35e-17

Cadherin-like;


The actual alignment was detected with superfamily member pfam16184:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 78.41  E-value: 5.35e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   526 HQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQP------LKGNEEEP---- 595
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPshghlaLKGAPGLPvtnf 80

                           90
                   ....*....|....*..
gi 270265871   596 -QWELAPGS---SHSGH 608
Cdd:pfam16184   81 tQADIDSGLvvyVHDGS 97
Cadherin_3 super family cl28802
Cadherin-like;
686-808 1.31e-14

Cadherin-like;


The actual alignment was detected with superfamily member pfam16184:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 71.86  E-value: 1.31e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   686 SKQHIFTIKVQPVDILSPQLYPGTTLEMTV-QEYQLTHFQknfLRYIDQDSDDQNLWYTLLTLPtdtdgnhqvRAGEIVL 764
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTGLRLWEgSSRPITPDL---LQAEDPDTPPEDLTYTVVQGP---------SHGHLAL 69

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 270265871   765 TDSPDTLIMHFTQAQVNQHKVAYqppQKLGIAPRVVQFTYQVED 808
Cdd:pfam16184   70 KGAPGLPVTNFTQADIDSGLVVY---VHDGSESTSDGFTFQVTD 110
Calx-beta super family cl02522
Calx-beta domain;
2011-2105 7.83e-14

Calx-beta domain;


The actual alignment was detected with superfamily member pfam03160:

Pssm-ID: 413355 [Multi-domain]  Cd Length: 91  Bit Score: 68.82  E-value: 7.83e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  2011 PVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSrksEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDL 2090
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYRT---EDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDD 78

                           90
                   ....*....|....*
gi 270265871  2091 gqpTLEGPEKFELLL 2105
Cdd:pfam03160   79 ---VYEGDENFFVLL 90
Cadherin_3 super family cl28802
Cadherin-like;
323-424 4.98e-09

Cadherin-like;


The actual alignment was detected with superfamily member pfam16184:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 55.69  E-value: 4.98e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   323 TALTPDALAAEDVESDPGDLVFNILNAPTHppghpgqqGYVVSTDDPlGLPVSFFTQQELRELKIAYQppaensHgerlf 402
Cdd:pfam16184   35 RPITPDLLQAEDPDTPPEDLTYTVVQGPSH--------GHLALKGAP-GLPVTNFTQADIDSGLVVYV------H----- 94

                           90       100
                   ....*....|....*....|..
gi 270265871   403 qlelevvDGDGAASDPFAFMVT 424
Cdd:pfam16184   95 -------DGSESTSDGFTFQVT 109
 
Name Accession Description Interval E-value
Frem_N pfam19309
Frem protein N-terminal domain; This entry represents a presumed domain found at the ...
 62-269 4.04e-123

Frem protein N-terminal domain; This entry represents a presumed domain found at the N-terminus of Frem related proteins.


Pssm-ID: 466034  Cd Length: 202  Bit Score: 385.92  E-value: 4.04e-123
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871    62 VLIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLD--ALPRLKGALSPRRFPCTFGPRQVQYTHFGSHSPGRARV 139
Cdd:pfam19309    1 ILIANRGLRVPFGRSVWLDPLRDLVIQVQPGDRCEVTVLDndPLPQRPGALSPRRFPCDFGPREVQYTHFGSRSPSRDRV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   140 LLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEKLRSWSRAIDRRVLDFASLKSgataTRRCRLTPLPHEDGp 219
Cdd:pfam19309   81 RLQLRYDAPTDTLVLPFTLEVEVVFSQLEIVTRNLPLTVEKLLGTSNPIDRRVLEFAYDPG----TERCKVTVLPGAGG- 155

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 270265871   220 LPKYGRLVDAVGAPLPrgkgVDCEAFLRAGVRYQHTAT-SSPNRDYVPMMV 269
Cdd:pfam19309  156 LPRYGRLVNATGAPLM----VDCEAFLRAGVRYQHTATtSSPNRDYVPMVV 202
Cadherin_3 pfam16184
Cadherin-like;
416-524 9.49e-34

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 126.56  E-value: 9.49e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   416 SDPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSsTHSIPISDKDNL-EEVKMAAVRGLRHGQLVVFGAP-AGCKYF 493
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPIT-PDLLQAEDPDTPpEDLTYTVVQGPSHGHLALKGAPgLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 270265871   494 TPADLAAGRVVYQHDGSNTYSDNIIFRMEDG 524
Cdd:pfam16184   81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1524-1627 5.86e-31

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 118.47  E-value: 5.86e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1524 RTFRIFITDVDNKKPILTIHR-LTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKILYNGS--RPVTTFTKQD 1600
Cdd:pfam16184    5 FTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGApgLPVTNFTQAD 84

                           90       100
                   ....*....|....*....|....*..
gi 270265871  1601 LNKNLISYKHDGSETTEDSFSLTVTDG 1627
Cdd:pfam16184   85 IDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
812-922 2.41e-29

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 113.85  E-value: 2.41e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   812 NSVPGTFTLFLQPVDNQPPEVT-NRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGESF 890
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTtNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 270265871   891 MQADVINGSVSYQHgRDQTTTSDTFHLEVSDG 922
Cdd:pfam16184   81 TQADIDSGLVVYVH-DGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1289-1406 1.44e-28

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 111.54  E-value: 1.44e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1289 HTTHRKVPIVVTLVDDETPHLTVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRnn 1368
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVT-- 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 270265871  1369 ltlgmNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDG 1406
Cdd:pfam16184   79 -----NFTQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1182-1287 1.24e-23

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 97.67  E-value: 1.24e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1182 FPIIILPTNDEQPKLFAHE-FKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGsQPIHSFTLKEI 1260
Cdd:pfam16184    7 FNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPG-LPVTNFTQADI 85

                           90       100
                   ....*....|....*....|....*..
gi 270265871  1261 qEASTIVYEHDDSETKEDSFEVWLSDG 1287
Cdd:pfam16184   86 -DSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1409-1515 3.52e-20

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 87.66  E-value: 3.52e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1409 TLTDHYFYVTIGNLDSVFPEVISKR-ITLIEGARVTLTNNLLTNSDINSSDEH-HFSITRAPSLGHLESSDYAGEPIASF 1486
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDlTYTVVQGPSHGHLALKGAPGLPVTNF 80

                           90       100
                   ....*....|....*....|....*....
gi 270265871  1487 TQLQLASNKISYVHTsNDEKKMDSFEFQV 1515
Cdd:pfam16184   81 TQADIDSGLVVYVHD-GSESTSDGFTFQV 108
Cadherin_3 pfam16184
Cadherin-like;
1645-1757 5.73e-20

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 86.89  E-value: 5.73e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1645 PQVMRVQIRSLDNRLPQITTNRGapaLKRLHTGHmgFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTR 1724
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVLTTNTG---LRLWEGSS--RPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVT 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 270265871  1725 VFTQADIDEMKISYVlNEGSNASKDIFYFSVED 1757
Cdd:pfam16184   79 NFTQADIDSGLVVYV-HDGSESTSDGFTFQVTD 110
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1775-1987 2.29e-19

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 95.63  E-value: 2.29e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1775 ICLEKEYYIVDEDSTFLEVTLTRRGY-LGETSFISIGTKDETAKKDKDFKWkTNKQIQFNPGQTTATWRVRIIPDNEYET 1853
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGdLTNTVYVDYRTEDGTANAGSDYEF-TEGTLVFKPGETQKEFRIGIIDDDIFEE 480

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1854 SETFQIILSEP---------------LMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQEL 1918
Cdd:TIGR00845  481 DEHFYVRLSNLrvgsedgileanhvsAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTV 560

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 270265871  1919 IVICSTRQGSATGTisstvlFSDYisrpEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLP 1987
Cdd:TIGR00845  561 IVPYRTVEGTARGG------GKDF----EDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEP 619
Cadherin_3 pfam16184
Cadherin-like;
1058-1173 7.30e-18

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 81.11  E-value: 7.30e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1058 VQVTVLPVDNVGPKVFVGESFIVYEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEkiasapgsKMSQSGSPIS 1137
Cdd:pfam16184    7 FNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLA--------LKGAPGLPVT 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 270265871  1138 AFSLRDIQVRHINYVqsiHKGVEPQEDQFTFYCSDG 1173
Cdd:pfam16184   79 NFTQADIDSGLVVYV---HDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
526-608 5.35e-17

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 78.41  E-value: 5.35e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   526 HQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQP------LKGNEEEP---- 595
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPshghlaLKGAPGLPvtnf 80

                           90
                   ....*....|....*..
gi 270265871   596 -QWELAPGS---SHSGH 608
Cdd:pfam16184   81 tQADIDSGLvvyVHDGS 97
Cadherin_3 pfam16184
Cadherin-like;
686-808 1.31e-14

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 71.86  E-value: 1.31e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   686 SKQHIFTIKVQPVDILSPQLYPGTTLEMTV-QEYQLTHFQknfLRYIDQDSDDQNLWYTLLTLPtdtdgnhqvRAGEIVL 764
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTGLRLWEgSSRPITPDL---LQAEDPDTPPEDLTYTVVQGP---------SHGHLAL 69

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 270265871   765 TDSPDTLIMHFTQAQVNQHKVAYqppQKLGIAPRVVQFTYQVED 808
Cdd:pfam16184   70 KGAPGLPVTNFTQADIDSGLVVY---VHDGSESTSDGFTFQVTD 110
Calx-beta pfam03160
Calx-beta domain;
2011-2105 7.83e-14

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 68.82  E-value: 7.83e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  2011 PVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSrksEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDL 2090
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYRT---EDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDD 78

                           90
                   ....*....|....*
gi 270265871  2091 gqpTLEGPEKFELLL 2105
Cdd:pfam03160   79 ---VYEGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1886-1984 1.17e-12

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 65.35  E-value: 1.17e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   1886 STVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTisstvlfSDYISRPedhtSILHFDKNETQKTCQ 1965
Cdd:smart00237    2 GSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAG-------SDYEPVP----GELTFPPGETEKEIR 70

                            90
                    ....*....|....*....
gi 270265871   1966 VLIIDDSLYEEEESFSVSL 1984
Cdd:smart00237   71 IKIIDDDIYEKDETFYVRL 89
Calx-beta pfam03160
Calx-beta domain;
1886-1984 2.06e-11

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 61.88  E-value: 2.06e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1886 STVYIPEAEYKIEEDIGELLIPV-RRSGDASQELIVICSTRQGSATGTisstvlfSDYISRPEDhtsiLHFDKNETQKTC 1964
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVvRMSGTLRRTVVVPYRTEDGTATAG-------DDYEPVEGE----LVFGPGETEKCI 70

                           90       100
                   ....*....|....*....|
gi 270265871  1965 QVLIIDDSLYEEEESFSVSL 1984
Cdd:pfam03160   71 NVTIIDDDVYEGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2015-2106 3.07e-10

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 58.81  E-value: 3.07e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   2015 FGDAEYHVNESARYVEVCVWRRGtDLSQPSSIAVRSrksEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDlgqPT 2094
Cdd:smart00237    6 FEQPVYTVSESDGEVEVCVVRTG-GARGPVVVPYST---EDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDD---DI 78

                            90
                    ....*....|..
gi 270265871   2095 LEGPEKFELLLQ 2106
Cdd:smart00237   79 YEKDETFYVRLS 90
Cadherin_3 pfam16184
Cadherin-like;
323-424 4.98e-09

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 55.69  E-value: 4.98e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   323 TALTPDALAAEDVESDPGDLVFNILNAPTHppghpgqqGYVVSTDDPlGLPVSFFTQQELRELKIAYQppaensHgerlf 402
Cdd:pfam16184   35 RPITPDLLQAEDPDTPPEDLTYTVVQGPSH--------GHLALKGAP-GLPVTNFTQADIDSGLVVYV------H----- 94

                           90       100
                   ....*....|....*....|..
gi 270265871   403 qlelevvDGDGAASDPFAFMVT 424
Cdd:pfam16184   95 -------DGSESTSDGFTFQVT 109
 
Name Accession Description Interval E-value
Frem_N pfam19309
Frem protein N-terminal domain; This entry represents a presumed domain found at the ...
 62-269 4.04e-123

Frem protein N-terminal domain; This entry represents a presumed domain found at the N-terminus of Frem related proteins.


Pssm-ID: 466034  Cd Length: 202  Bit Score: 385.92  E-value: 4.04e-123
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871    62 VLIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLD--ALPRLKGALSPRRFPCTFGPRQVQYTHFGSHSPGRARV 139
Cdd:pfam19309    1 ILIANRGLRVPFGRSVWLDPLRDLVIQVQPGDRCEVTVLDndPLPQRPGALSPRRFPCDFGPREVQYTHFGSRSPSRDRV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   140 LLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEKLRSWSRAIDRRVLDFASLKSgataTRRCRLTPLPHEDGp 219
Cdd:pfam19309   81 RLQLRYDAPTDTLVLPFTLEVEVVFSQLEIVTRNLPLTVEKLLGTSNPIDRRVLEFAYDPG----TERCKVTVLPGAGG- 155

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 270265871   220 LPKYGRLVDAVGAPLPrgkgVDCEAFLRAGVRYQHTAT-SSPNRDYVPMMV 269
Cdd:pfam19309  156 LPRYGRLVNATGAPLM----VDCEAFLRAGVRYQHTATtSSPNRDYVPMVV 202
Cadherin_3 pfam16184
Cadherin-like;
416-524 9.49e-34

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 126.56  E-value: 9.49e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   416 SDPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSsTHSIPISDKDNL-EEVKMAAVRGLRHGQLVVFGAP-AGCKYF 493
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPIT-PDLLQAEDPDTPpEDLTYTVVQGPSHGHLALKGAPgLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 270265871   494 TPADLAAGRVVYQHDGSNTYSDNIIFRMEDG 524
Cdd:pfam16184   81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1524-1627 5.86e-31

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 118.47  E-value: 5.86e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1524 RTFRIFITDVDNKKPILTIHR-LTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKILYNGS--RPVTTFTKQD 1600
Cdd:pfam16184    5 FTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGApgLPVTNFTQAD 84

                           90       100
                   ....*....|....*....|....*..
gi 270265871  1601 LNKNLISYKHDGSETTEDSFSLTVTDG 1627
Cdd:pfam16184   85 IDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
812-922 2.41e-29

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 113.85  E-value: 2.41e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   812 NSVPGTFTLFLQPVDNQPPEVT-NRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGESF 890
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTtNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 270265871   891 MQADVINGSVSYQHgRDQTTTSDTFHLEVSDG 922
Cdd:pfam16184   81 TQADIDSGLVVYVH-DGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1289-1406 1.44e-28

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 111.54  E-value: 1.44e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1289 HTTHRKVPIVVTLVDDETPHLTVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRnn 1368
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVT-- 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 270265871  1369 ltlgmNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDG 1406
Cdd:pfam16184   79 -----NFTQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1182-1287 1.24e-23

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 97.67  E-value: 1.24e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1182 FPIIILPTNDEQPKLFAHE-FKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGsQPIHSFTLKEI 1260
Cdd:pfam16184    7 FNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPG-LPVTNFTQADI 85

                           90       100
                   ....*....|....*....|....*..
gi 270265871  1261 qEASTIVYEHDDSETKEDSFEVWLSDG 1287
Cdd:pfam16184   86 -DSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1409-1515 3.52e-20

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 87.66  E-value: 3.52e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1409 TLTDHYFYVTIGNLDSVFPEVISKR-ITLIEGARVTLTNNLLTNSDINSSDEH-HFSITRAPSLGHLESSDYAGEPIASF 1486
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDlTYTVVQGPSHGHLALKGAPGLPVTNF 80

                           90       100
                   ....*....|....*....|....*....
gi 270265871  1487 TQLQLASNKISYVHTsNDEKKMDSFEFQV 1515
Cdd:pfam16184   81 TQADIDSGLVVYVHD-GSESTSDGFTFQV 108
Cadherin_3 pfam16184
Cadherin-like;
1645-1757 5.73e-20

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 86.89  E-value: 5.73e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1645 PQVMRVQIRSLDNRLPQITTNRGapaLKRLHTGHmgFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTR 1724
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVLTTNTG---LRLWEGSS--RPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVT 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 270265871  1725 VFTQADIDEMKISYVlNEGSNASKDIFYFSVED 1757
Cdd:pfam16184   79 NFTQADIDSGLVVYV-HDGSESTSDGFTFQVTD 110
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1775-1987 2.29e-19

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 95.63  E-value: 2.29e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1775 ICLEKEYYIVDEDSTFLEVTLTRRGY-LGETSFISIGTKDETAKKDKDFKWkTNKQIQFNPGQTTATWRVRIIPDNEYET 1853
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGdLTNTVYVDYRTEDGTANAGSDYEF-TEGTLVFKPGETQKEFRIGIIDDDIFEE 480

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1854 SETFQIILSEP---------------LMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQEL 1918
Cdd:TIGR00845  481 DEHFYVRLSNLrvgsedgileanhvsAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTV 560

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 270265871  1919 IVICSTRQGSATGTisstvlFSDYisrpEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLP 1987
Cdd:TIGR00845  561 IVPYRTVEGTARGG------GKDF----EDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEP 619
Cadherin_3 pfam16184
Cadherin-like;
1058-1173 7.30e-18

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 81.11  E-value: 7.30e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1058 VQVTVLPVDNVGPKVFVGESFIVYEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEkiasapgsKMSQSGSPIS 1137
Cdd:pfam16184    7 FNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLA--------LKGAPGLPVT 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 270265871  1138 AFSLRDIQVRHINYVqsiHKGVEPQEDQFTFYCSDG 1173
Cdd:pfam16184   79 NFTQADIDSGLVVYV---HDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
526-608 5.35e-17

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 78.41  E-value: 5.35e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   526 HQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQP------LKGNEEEP---- 595
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPshghlaLKGAPGLPvtnf 80

                           90
                   ....*....|....*..
gi 270265871   596 -QWELAPGS---SHSGH 608
Cdd:pfam16184   81 tQADIDSGLvvyVHDGS 97
Cadherin_3 pfam16184
Cadherin-like;
686-808 1.31e-14

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 71.86  E-value: 1.31e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   686 SKQHIFTIKVQPVDILSPQLYPGTTLEMTV-QEYQLTHFQknfLRYIDQDSDDQNLWYTLLTLPtdtdgnhqvRAGEIVL 764
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTGLRLWEgSSRPITPDL---LQAEDPDTPPEDLTYTVVQGP---------SHGHLAL 69

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 270265871   765 TDSPDTLIMHFTQAQVNQHKVAYqppQKLGIAPRVVQFTYQVED 808
Cdd:pfam16184   70 KGAPGLPVTNFTQADIDSGLVVY---VHDGSESTSDGFTFQVTD 110
Calx-beta pfam03160
Calx-beta domain;
2011-2105 7.83e-14

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 68.82  E-value: 7.83e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  2011 PVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSrksEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDL 2090
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYRT---EDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDD 78

                           90
                   ....*....|....*
gi 270265871  2091 gqpTLEGPEKFELLL 2105
Cdd:pfam03160   79 ---VYEGDENFFVLL 90
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1872-2133 5.55e-13

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 74.83  E-value: 5.55e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1872 PEMATVEIVDPGDE--STVYIPEAEYKIEEDIGELLIPV-RRSGDASQELIVICSTRQGSATGTisstvlfSDYISRped 1948
Cdd:TIGR00845  384 VSMHEVATDDEENDpvSKIFFEPGHYTCLENCGTVALTVvRRGGDLTNTVYVDYRTEDGTANAG-------SDYEFT--- 453

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1949 hTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSL-RLPVG--------------GQLGARFPTTkVTILADryDEP-V 2012
Cdd:TIGR00845  454 -EGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLsNLRVGsedgileanhvsavAQLASPNTAT-VTILDD--DHAgI 529

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  2013 LHFGDAEYHVNESARYVEVCVWR----RGTdlsqpssIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILD 2088
Cdd:TIGR00845  530 FTFEEDVFHVSESIGIMEVKVLRtsgaRGT-------VIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVD 602

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 270265871  2089 DlgqPTLEGPEKFELLLQMPMgaVLGEPNKTTIFIEDTITDCKQS 2133
Cdd:TIGR00845  603 D---EEYEKNDTFFIELGEPR--WAKRGIKAALLLNETITDDDQK 642
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1886-1984 1.17e-12

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 65.35  E-value: 1.17e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   1886 STVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTisstvlfSDYISRPedhtSILHFDKNETQKTCQ 1965
Cdd:smart00237    2 GSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAG-------SDYEPVP----GELTFPPGETEKEIR 70

                            90
                    ....*....|....*....
gi 270265871   1966 VLIIDDSLYEEEESFSVSL 1984
Cdd:smart00237   71 IKIIDDDIYEKDETFYVRL 89
Calx-beta pfam03160
Calx-beta domain;
1886-1984 2.06e-11

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 61.88  E-value: 2.06e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1886 STVYIPEAEYKIEEDIGELLIPV-RRSGDASQELIVICSTRQGSATGTisstvlfSDYISRPEDhtsiLHFDKNETQKTC 1964
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVvRMSGTLRRTVVVPYRTEDGTATAG-------DDYEPVEGE----LVFGPGETEKCI 70

                           90       100
                   ....*....|....*....|
gi 270265871  1965 QVLIIDDSLYEEEESFSVSL 1984
Cdd:pfam03160   71 NVTIIDDDVYEGDENFFVLL 90
Calx-beta pfam03160
Calx-beta domain;
1778-1862 2.74e-10

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 58.80  E-value: 2.74e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1778 EKEYYIVDEDSTFLEVTLTRR-GYLGETSFISIGTKDETAKKDKDFKwKTNKQIQFNPGQTTATWRVRIIPDNEYETSET 1856
Cdd:pfam03160    7 EPPTYQVSENDGVAEVCVVRMsGTLRRTVVVPYRTEDGTATAGDDYE-PVEGELVFGPGETEKCINVTIIDDDVYEGDEN 85


                   ....*.
gi 270265871  1857 FQIILS 1862
Cdd:pfam03160   86 FFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2015-2106 3.07e-10

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 58.81  E-value: 3.07e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   2015 FGDAEYHVNESARYVEVCVWRRGtDLSQPSSIAVRSrksEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDlgqPT 2094
Cdd:smart00237    6 FEQPVYTVSESDGEVEVCVVRTG-GARGPVVVPYST---EDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDD---DI 78

                            90
                    ....*....|..
gi 270265871   2095 LEGPEKFELLLQ 2106
Cdd:smart00237   79 YEKDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1782-1862 1.74e-09

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 56.49  E-value: 1.74e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   1782 YIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKwKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQIIL 1861
Cdd:smart00237   11 YTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYE-PVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRL 89


                    .
gi 270265871   1862 S 1862
Cdd:smart00237   90 S 90
Cadherin_3 pfam16184
Cadherin-like;
323-424 4.98e-09

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 55.69  E-value: 4.98e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871   323 TALTPDALAAEDVESDPGDLVFNILNAPTHppghpgqqGYVVSTDDPlGLPVSFFTQQELRELKIAYQppaensHgerlf 402
Cdd:pfam16184   35 RPITPDLLQAEDPDTPPEDLTYTVVQGPSH--------GHLALKGAP-GLPVTNFTQADIDSGLVVYV------H----- 94

                           90       100
                   ....*....|....*....|..
gi 270265871   403 qlelevvDGDGAASDPFAFMVT 424
Cdd:pfam16184   95 -------DGSESTSDGFTFQVT 109
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1784-1899 5.90e-05

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 48.25  E-value: 5.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270265871  1784 VDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKD-KDFKwKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQIILS 1862
Cdd:TIGR00845  539 VSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGGgKDFE-DTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELG 617

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 270265871  1863 EP-LMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEE 1899
Cdd:TIGR00845  618 EPrWAKRGIKAALLLNETITDDDQKLTSKEEEERRIAE 655
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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