NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|282165817|ref|NP_001161302|]
View 

transmembrane emp24 domain-containing protein 5 isoform 2 precursor [Homo sapiens]

Protein Classification

emp24/gp25L/p24 family protein( domain architecture ID 10471359)

emp24/gp25L/p24 family protein such as various transmembrane emp24 domain-containing proteins, which are involved in vesicular protein trafficking

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
EMP24_GP25L pfam01105
emp24/gp25L/p24 family/GOLD; Members of this family are implicated in bringing cargo forward ...
 35-162 1.09e-27

emp24/gp25L/p24 family/GOLD; Members of this family are implicated in bringing cargo forward from the ER and binding to coat proteins by their cytoplasmic domains. This domain corresponds closely to the beta-strand rich GOLD domain described in. The GOLD domain is always found combined with lipid- or membrane-association domains.


:

Pssm-ID: 426051  Cd Length: 181  Bit Score: 102.76  E-value: 1.09e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282165817   35 DFTFTLPAGQKECFYQPMPLKASLEIEYQVLDGAGLDIDFHLASPE--GKTLVFE-QRKSDGVHTVET-EVGDYMFCFDN 110
Cdd:pfam01105   1 ALTFELPAGEKECFYEEVPKGTLVTGSYQVISGGGLDVDFTVTDPDgnGNVIYSKkDRKSGGDFSFTAtESGEYKFCFDN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 282165817  111 TFSTISEKVIFFELILDNmgeqaqEQEDWKKYITGTDILDM-----KLEDILDPIIK 162
Cdd:pfam01105  81 SFSTFSSKTVSFDIKVGS------EAKDYDDVAKKEKLDPLeeelrKLEDQLNDIKR 131
 
Name Accession Description Interval E-value
EMP24_GP25L pfam01105
emp24/gp25L/p24 family/GOLD; Members of this family are implicated in bringing cargo forward ...
 35-162 1.09e-27

emp24/gp25L/p24 family/GOLD; Members of this family are implicated in bringing cargo forward from the ER and binding to coat proteins by their cytoplasmic domains. This domain corresponds closely to the beta-strand rich GOLD domain described in. The GOLD domain is always found combined with lipid- or membrane-association domains.


Pssm-ID: 426051  Cd Length: 181  Bit Score: 102.76  E-value: 1.09e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282165817   35 DFTFTLPAGQKECFYQPMPLKASLEIEYQVLDGAGLDIDFHLASPE--GKTLVFE-QRKSDGVHTVET-EVGDYMFCFDN 110
Cdd:pfam01105   1 ALTFELPAGEKECFYEEVPKGTLVTGSYQVISGGGLDVDFTVTDPDgnGNVIYSKkDRKSGGDFSFTAtESGEYKFCFDN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 282165817  111 TFSTISEKVIFFELILDNmgeqaqEQEDWKKYITGTDILDM-----KLEDILDPIIK 162
Cdd:pfam01105  81 SFSTFSSKTVSFDIKVGS------EAKDYDDVAKKEKLDPLeeelrKLEDQLNDIKR 131
 
Name Accession Description Interval E-value
EMP24_GP25L pfam01105
emp24/gp25L/p24 family/GOLD; Members of this family are implicated in bringing cargo forward ...
 35-162 1.09e-27

emp24/gp25L/p24 family/GOLD; Members of this family are implicated in bringing cargo forward from the ER and binding to coat proteins by their cytoplasmic domains. This domain corresponds closely to the beta-strand rich GOLD domain described in. The GOLD domain is always found combined with lipid- or membrane-association domains.


Pssm-ID: 426051  Cd Length: 181  Bit Score: 102.76  E-value: 1.09e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282165817   35 DFTFTLPAGQKECFYQPMPLKASLEIEYQVLDGAGLDIDFHLASPE--GKTLVFE-QRKSDGVHTVET-EVGDYMFCFDN 110
Cdd:pfam01105   1 ALTFELPAGEKECFYEEVPKGTLVTGSYQVISGGGLDVDFTVTDPDgnGNVIYSKkDRKSGGDFSFTAtESGEYKFCFDN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 282165817  111 TFSTISEKVIFFELILDNmgeqaqEQEDWKKYITGTDILDM-----KLEDILDPIIK 162
Cdd:pfam01105  81 SFSTFSSKTVSFDIKVGS------EAKDYDDVAKKEKLDPLeeelrKLEDQLNDIKR 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH