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Conserved domains on  [gi|262205665|ref|NP_001159864|]
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trophoblast glycoprotein precursor [Homo sapiens]

Protein Classification

LRRNT and LRR domain-containing protein( domain architecture ID 12183445)

protein containing domains LRRNT, LRR, and LRRCT

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-285 2.67e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 2.67e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205665  79 NRNLTEVPTDLPA--YVRNLFLTGNQLAVLPAgAFARrppLAELAALNLSGSRLDEVRAgAFEHLPSLRQLDLSHNPLAD 156
Cdd:COG4886  122 GNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGN---LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205665 157 LSpfafsgsnASVSAPSPLVELIL--NHI--VPPEderqnrsfegmvvaalLAGraLQGLRRLELASNHFLYLPrdVLAQ 232
Cdd:COG4886  197 LP--------EPLGNLTNLEELDLsgNQLtdLPEP----------------LAN--LTNLETLDLSNNQLTDLP--ELGN 248

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 262205665 233 LPSLRHLDLSNNSLVSLTyvSFRNLTHLESLHLEDNALKVLHNGTLAELQGLP 285
Cdd:COG4886  249 LTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLN 299
LRRCT smart00082
Leucine rich repeat C-terminal domain;
294-345 1.34e-13

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 64.76  E-value: 1.34e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 262205665   294 NPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRvLLELNSADLDCD 345
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
61-95 1.21e-05

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.92  E-value: 1.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 262205665    61 QCPALCECSeaARTVKCVNRNLTEVPTDLPAYVRN 95
Cdd:smart00013   1 ACPAPCNCS--GTAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-285 2.67e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 2.67e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205665  79 NRNLTEVPTDLPA--YVRNLFLTGNQLAVLPAgAFARrppLAELAALNLSGSRLDEVRAgAFEHLPSLRQLDLSHNPLAD 156
Cdd:COG4886  122 GNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGN---LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205665 157 LSpfafsgsnASVSAPSPLVELIL--NHI--VPPEderqnrsfegmvvaalLAGraLQGLRRLELASNHFLYLPrdVLAQ 232
Cdd:COG4886  197 LP--------EPLGNLTNLEELDLsgNQLtdLPEP----------------LAN--LTNLETLDLSNNQLTDLP--ELGN 248

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 262205665 233 LPSLRHLDLSNNSLVSLTyvSFRNLTHLESLHLEDNALKVLHNGTLAELQGLP 285
Cdd:COG4886  249 LTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLN 299
LRRCT smart00082
Leucine rich repeat C-terminal domain;
294-345 1.34e-13

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 64.76  E-value: 1.34e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 262205665   294 NPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRvLLELNSADLDCD 345
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
210-270 9.16e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 9.16e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 262205665  210 QGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNAL 270
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 265-345 4.69e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.39  E-value: 4.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205665   265 LEDNALKVLHNGTLAELQGLPHIRvfLDNNPWVCDCHMADMVTWLKETEV-VQGKDRLTCAYPEKMRNRVLLELNSADLD 343
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEID--LSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGQPLLGIPLLDSG 79


                   ..
gi 262205665   344 CD 345
Cdd:TIGR00864   80 CD 81
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 209-298 2.19e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 2.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205665 209 LQGLRRLE--------LASNHFLYL-PRDVLAQLPSLRHLDLSNNSLVSLTyvSFRNLTHLESLHLEDNALKVLHNgTLA 279
Cdd:cd21340   86 LENLTNLEelhienqrLPPGEKLTFdPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEE-LLD 162

                         90       100
                 ....*....|....*....|
gi 262205665 280 ELQGLPHIR-VFLDNNPwVC 298
Cdd:cd21340  163 LLSSWPSLReLDLTGNP-VC 181
LRRNT smart00013
Leucine rich repeat N-terminal domain;
61-95 1.21e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.92  E-value: 1.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 262205665    61 QCPALCECSeaARTVKCVNRNLTEVPTDLPAYVRN 95
Cdd:smart00013   1 ACPAPCNCS--GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 61-90 3.21e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.61  E-value: 3.21e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 262205665   61 QCPALCECSeaARTVKCVNRNLTEVPTDLP 90
Cdd:pfam01462   1 ACPVPCHCS--ATVVNCSDRGLTAVPRDLP 28
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 120-270 6.75e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 6.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205665 120 LAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVsapsplveLILNhivppedeRQNRSFEGMV 199
Cdd:PLN00113  71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSL--------RYLN--------LSNNNFTGSI 134

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 262205665 200 vaallAGRALQGLRRLELASNHFL-YLPRDVlAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNAL 270
Cdd:PLN00113 135 -----PRGSIPNLETLDLSNNMLSgEIPNDI-GSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL 200
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-285 2.67e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 2.67e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205665  79 NRNLTEVPTDLPA--YVRNLFLTGNQLAVLPAgAFARrppLAELAALNLSGSRLDEVRAgAFEHLPSLRQLDLSHNPLAD 156
Cdd:COG4886  122 GNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGN---LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205665 157 LSpfafsgsnASVSAPSPLVELIL--NHI--VPPEderqnrsfegmvvaalLAGraLQGLRRLELASNHFLYLPrdVLAQ 232
Cdd:COG4886  197 LP--------EPLGNLTNLEELDLsgNQLtdLPEP----------------LAN--LTNLETLDLSNNQLTDLP--ELGN 248

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 262205665 233 LPSLRHLDLSNNSLVSLTyvSFRNLTHLESLHLEDNALKVLHNGTLAELQGLP 285
Cdd:COG4886  249 LTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLN 299
LRRCT smart00082
Leucine rich repeat C-terminal domain;
294-345 1.34e-13

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 64.76  E-value: 1.34e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 262205665   294 NPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRvLLELNSADLDCD 345
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
210-270 9.16e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 9.16e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 262205665  210 QGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNAL 270
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-273 2.02e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.26  E-value: 2.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205665  73 RTVKCVNRNLTEVPTDLPAYV--RNLFLTGNQLAVLPAGAFarrpPLAELAALNLSGSRLDEVrAGAFEHLPSLRQLDLS 150
Cdd:COG4886  139 KELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPEELG----NLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLS 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205665 151 HNPLADLsPFAFSGSNAsvsapspLVELILNHivppederqNRsfegmvVAALLAGRALQGLRRLELASNHFLYLPrdVL 230
Cdd:COG4886  214 GNQLTDL-PEPLANLTN-------LETLDLSN---------NQ------LTDLPELGNLTNLEELDLSNNQLTDLP--PL 268

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 262205665 231 AQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVL 273
Cdd:COG4886  269 ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311
LRR_8 pfam13855
Leucine rich repeat;
93-154 3.27e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 3.27e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 262205665   93 VRNLFLTGNQLAVLPAGAFARRPPLAELaalNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPL 154
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVL---DLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
234-295 2.16e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 2.16e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 262205665  234 PSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTlaeLQGLPHIRV-FLDNNP 295
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGA---FSGLPSLRYlDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
119-182 3.39e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 3.39e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 262205665  119 ELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNAsvsapspLVELILNH 182
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPS-------LRYLDLSG 58
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 265-345 4.69e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.39  E-value: 4.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205665   265 LEDNALKVLHNGTLAELQGLPHIRvfLDNNPWVCDCHMADMVTWLKETEV-VQGKDRLTCAYPEKMRNRVLLELNSADLD 343
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEID--LSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGQPLLGIPLLDSG 79


                   ..
gi 262205665   344 CD 345
Cdd:TIGR00864   80 CD 81
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 209-298 2.19e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 2.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205665 209 LQGLRRLE--------LASNHFLYL-PRDVLAQLPSLRHLDLSNNSLVSLTyvSFRNLTHLESLHLEDNALKVLHNgTLA 279
Cdd:cd21340   86 LENLTNLEelhienqrLPPGEKLTFdPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEE-LLD 162

                         90       100
                 ....*....|....*....|
gi 262205665 280 ELQGLPHIR-VFLDNNPwVC 298
Cdd:cd21340  163 LLSSWPSLReLDLTGNP-VC 181
LRRNT smart00013
Leucine rich repeat N-terminal domain;
61-95 1.21e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.92  E-value: 1.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 262205665    61 QCPALCECSeaARTVKCVNRNLTEVPTDLPAYVRN 95
Cdd:smart00013   1 ACPAPCNCS--GTAVDCSGRGLTEVPLDLPPDTTL 33
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
209-294 1.29e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.24  E-value: 1.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205665 209 LQGLRRLELASNhflylprDVLAQLPSLRHLDLSNNSLVSLTyVSFRNLTHLESLHLEDNALKVLHngtlAELQGLPHIR 288
Cdd:COG4886   95 LTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLP----EPLGNLTNLK 162


                 ....*..
gi 262205665 289 VF-LDNN 294
Cdd:COG4886  163 SLdLSNN 169
LRR_8 pfam13855
Leucine rich repeat;
142-246 3.54e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 3.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205665  142 PSLRQLDLSHNPLADLSPFAFSGsnasvsapsplvelilnhivppederqnrsfegmvvaallagraLQGLRRLELASNH 221
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKG--------------------------------------------LSNLKVLDLSNNL 36

                          90       100
                  ....*....|....*....|....*
gi 262205665  222 FLYLPRDVLAQLPSLRHLDLSNNSL 246
Cdd:pfam13855  37 LTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 234-268 2.21e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 2.21e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 262205665  234 PSLRHLDLSNNSLVSLTyvSFRNLTHLESLHLEDN 268
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 61-90 3.21e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.61  E-value: 3.21e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 262205665   61 QCPALCECSeaARTVKCVNRNLTEVPTDLP 90
Cdd:pfam01462   1 ACPVPCHCS--ATVVNCSDRGLTAVPRDLP 28
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 120-270 6.75e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 6.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205665 120 LAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVsapsplveLILNhivppedeRQNRSFEGMV 199
Cdd:PLN00113  71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSL--------RYLN--------LSNNNFTGSI 134

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 262205665 200 vaallAGRALQGLRRLELASNHFL-YLPRDVlAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNAL 270
Cdd:PLN00113 135 -----PRGSIPNLETLDLSNNMLSgEIPNDI-GSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL 200
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 228-294 3.56e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 3.56e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 262205665 228 DVLAQLPSLRHLDLSNNSLVSLTyvSFRNLTHLESLHLEDNALKVLHNgtlaeLQGLPHIRV-FLDNN 294
Cdd:cd21340   18 DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN-----LENLVNLKKlYLGGN 78
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-185 4.11e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.15  E-value: 4.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205665  81 NLTEVPTDLPAY--VRNLFLTGNQLAVLPAgaFARrppLAELAALNLSGSRLDEVRAGAfeHLPSLRQLDLSHNPLADLS 158
Cdd:COG4886  216 QLTDLPEPLANLtnLETLDLSNNQLTDLPE--LGN---LTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK 288

                         90       100
                 ....*....|....*....|....*..
gi 262205665 159 PFAFSGSNASVSAPSPLVELILNHIVP 185
Cdd:COG4886  289 LKELELLLGLNSLLLLLLLLNLLELLI 315
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 123-158 4.23e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 4.23e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 262205665 123 LNLSGSRLDEVRAgaFEHLPSLRQLDLSHNPLADLS 158
Cdd:cd21340  125 LNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLE 158
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
152-295 9.67e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 37.99  E-value: 9.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205665 152 NPLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLA 231
Cdd:COG4886   14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 262205665 232 QLPSLRHLDLSNNSLVSltyvsfrNLTHLESLHLEDNALKVLhngtLAELQGLPHIRV-FLDNNP 295
Cdd:COG4886   94 DLTNLTELDLSGNEELS-------NLTNLESLDLSGNQLTDL----PEELANLTNLKElDLSNNQ 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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