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Conserved domains on  [gi|259490302|ref|NP_001159352|]
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epidermal growth factor-like protein 8 isoform 2 precursor [Rattus norvegicus]

Protein Classification

EMI and EGF_CA domain-containing protein( domain architecture ID 10540656)

EMI and EGF_CA domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 36-101 1.21e-18

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


:

Pssm-ID: 462204  Cd Length: 69  Bit Score: 77.85  E-value: 1.21e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 259490302   36 VCS-KQTLLVPLRYNESYSQPVYRPYLTLCAGRRICSTYRTTYRVAWREVRREVQQTHVVCCQGWKK 101
Cdd:pfam07546   3 VCAyKVVSCVVVTGTESYVQPVYKPYLTWCAGHRRCSTYRTTYRPAYRQVYKTVTRLEWRCCPGWGG 69
EGF_CA smart00179
Calcium-binding EGF-like domain;
143-170 6.18e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 6.18e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 259490302   143 DVDECrTSLTLCSHG--CLNTLGSFTCSCP 170
Cdd:smart00179   1 DIDEC-ASGNPCQNGgtCVNTVGSYRCECP 29
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 108-181 3.45e-04

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member cd01475:

Pssm-ID: 469594 [Multi-domain]  Cd Length: 224  Bit Score: 40.83  E-value: 3.45e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 259490302 108 TCEAICSKpcLNGGVCAGPDQCECASgwagkhcHVdvdecrtsltlCSHGCLNTLGSFTCSCPNPLVLGPDGRA 181
Cdd:cd01475  171 TIEELTKK--FQGKICVVPDLCATLS-------HV-----------CQQVCISTPGSYLCACTEGYALLEDNKT 224
 
Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 36-101 1.21e-18

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 77.85  E-value: 1.21e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 259490302   36 VCS-KQTLLVPLRYNESYSQPVYRPYLTLCAGRRICSTYRTTYRVAWREVRREVQQTHVVCCQGWKK 101
Cdd:pfam07546   3 VCAyKVVSCVVVTGTESYVQPVYKPYLTWCAGHRRCSTYRTTYRPAYRQVYKTVTRLEWRCCPGWGG 69
EGF_CA smart00179
Calcium-binding EGF-like domain;
143-170 6.18e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 6.18e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 259490302   143 DVDECrTSLTLCSHG--CLNTLGSFTCSCP 170
Cdd:smart00179   1 DIDEC-ASGNPCQNGgtCVNTVGSYRCECP 29
EGF_CA pfam07645
Calcium-binding EGF domain;
143-170 2.21e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 2.21e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 259490302  143 DVDECRTSLTLCSHG--CLNTLGSFTCSCP 170
Cdd:pfam07645   1 DVDECATGTHNCPANtvCVNTIGSFECRCP 30
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 108-181 3.45e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.83  E-value: 3.45e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 259490302 108 TCEAICSKpcLNGGVCAGPDQCECASgwagkhcHVdvdecrtsltlCSHGCLNTLGSFTCSCPNPLVLGPDGRA 181
Cdd:cd01475  171 TIEELTKK--FQGKICVVPDLCATLS-------HV-----------CQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 143-182 5.75e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.75e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 259490302 143 DVDECrTSLTLCSHG--CLNTLGSFTCSCPNplvlGPDGRAC 182
Cdd:cd00054    1 DIDEC-ASGNPCQNGgtCVNTVGSYRCSCPP----GYTGRNC 37
 
Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 36-101 1.21e-18

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 77.85  E-value: 1.21e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 259490302   36 VCS-KQTLLVPLRYNESYSQPVYRPYLTLCAGRRICSTYRTTYRVAWREVRREVQQTHVVCCQGWKK 101
Cdd:pfam07546   3 VCAyKVVSCVVVTGTESYVQPVYKPYLTWCAGHRRCSTYRTTYRPAYRQVYKTVTRLEWRCCPGWGG 69
EGF_CA smart00179
Calcium-binding EGF-like domain;
143-170 6.18e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 6.18e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 259490302   143 DVDECrTSLTLCSHG--CLNTLGSFTCSCP 170
Cdd:smart00179   1 DIDEC-ASGNPCQNGgtCVNTVGSYRCECP 29
EGF_CA pfam07645
Calcium-binding EGF domain;
143-170 2.21e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 2.21e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 259490302  143 DVDECRTSLTLCSHG--CLNTLGSFTCSCP 170
Cdd:pfam07645   1 DVDECATGTHNCPANtvCVNTIGSFECRCP 30
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 108-181 3.45e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.83  E-value: 3.45e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 259490302 108 TCEAICSKpcLNGGVCAGPDQCECASgwagkhcHVdvdecrtsltlCSHGCLNTLGSFTCSCPNPLVLGPDGRA 181
Cdd:cd01475  171 TIEELTKK--FQGKICVVPDLCATLS-------HV-----------CQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 143-182 5.75e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.75e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 259490302 143 DVDECrTSLTLCSHG--CLNTLGSFTCSCPNplvlGPDGRAC 182
Cdd:cd00054    1 DIDEC-ASGNPCQNGgtCVNTVGSYRCSCPP----GYTGRNC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 154-182 1.19e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 35.68  E-value: 1.19e-03
                          10        20
                  ....*....|....*....|....*....
gi 259490302  154 CSHGCLNTLGSFTCSCPNPLVLGPDGRAC 182
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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