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Conserved domains on  [gi|256818796|ref|NP_001157973|]
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eukaryotic translation initiation factor 4E transporter isoform a [Homo sapiens]

Protein Classification

EIF4E-T and Atrophin-1 domain-containing protein( domain architecture ID 12106253)

EIF4E-T and Atrophin-1 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
EIF4E-T pfam10477
Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E; EIF4E-T is the transporter ...
30-711 6.71e-162

Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E; EIF4E-T is the transporter protein for shuttling the mRNA cap-binding protein EIF4E protein, targeting it for nuclear import. EIF4E-T contains several key binding domains including two functional leucine-rich NESs (nuclear export signals) between residues 438-447 and 613-638 in the human protein. The other two binding domains are an EIF4E-binding site, between residues 27-42 in Q9EST3, and a bipartite NLS (nuclear localization signals) between 194-211, and these lie in family EIF4E-T_N. EIF4E is the eukaryotic translation initiation factor 4E that is the rate-limiting factor for cap-dependent translation initiation.


:

Pssm-ID: 371079  Cd Length: 646  Bit Score: 490.29  E-value: 6.71e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796   30 YTKEELLDIKELPHSKQRPSCLSEKY-DSDGVWDPEKWHASLYPASGRSSPVESLKKELDTDRPSLVRRIVDPRERV--- 105
Cdd:pfam10477   1 YSKEDLLALRYEPSSRQRPSCLNRLElQTLGFWDPEKWHSSLYPSNKRSGLVSSRRALRNRERANNYYQRFDPRDRVlgh 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  106 KEDDLDVVLSPQRRSFGGGCH---------VTAAV--SSRRSGSPLEkdsdglrlLGGRRIGSGRII------------- 161
Cdd:pfam10477  81 KESQDDVVLSPQRRSFGGGCHvvpqdheqpVASSPtfSSSREGSPLN--------LQERRIGSGRLLprdyknqpadear 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  162 -------------SARTFEKDHRLSDKDLRD----LRDRDRERDFKDKRFRREFG------------------------- 199
Cdd:pfam10477 153 ierekdrspngsgSSRQDEEDQRNNQQNLRTfsgrHNERGRDGDRRSKRNRRTFGrfqydgkkpvdrgrrisnkdkfsfq 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  200 DSKRVFGERRRNDSYTEEEPEWFSAGPTSQSETIELTGFDDKilEEDHKGRKRTRRRTASVKEGIVECNGGVAEEDEVEV 279
Cdd:pfam10477 233 DRGKRYNSRRRNDSYTEEEPEWFSAGPTSQHETIELHGFDDK--EEDNKRRSRTRVKTESFKELDLECNGGVSEEPESSS 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  280 ILAQEPAADQEVPRDAVLPEQSP-----GDFDFNEFFNLDK-VPCLASMIEDVLGEGSVSASRFSRWFSnpsrsgSRSSS 353
Cdd:pfam10477 311 ILSLNVVEEQESPKKEVLPENSPvnqpeGEFNFDAFLNMDPlDNGLASNDEDVGQEESKGTSRFSRWFG------PNESS 384
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  354 LGSTPHEELERLAGLEQAILSPgqnsgnyfapipledhaenkvDILEMLQKAKVDLKpllsSLSANKEKLKESSHSGVVL 433
Cdd:pfam10477 385 LNNTPHPPLRRESGLQDAIRIP---------------------SVLDLLQKAKVDLR----DLMATKEKLPTSVHSGVVL 439
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  434 SVEEVEAGLkglkvdqqvknstpfmaehleetlsavtnnrqlkkDGDMTAFNKLVSTMKASGTLP--------------- 498
Cdd:pfam10477 440 SVEEVEKGL-----------------------------------DRDTEAFNKLLQQLGSQGTQHhsvndsaptindsna 484
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  499 ----SQPKVSRNLESHLMSPAEIPGQPVP----------KNILQELLGQPVQRPASSNLLSGlmgsleptTSLLGQRAPS 564
Cdd:pfam10477 485 gqlaNQPVPYHIQENHQDQQAKFLGVHTPnifaqpnmeiQHLIQELVRPDISHEFLEKELSN--------PSTLGHTKDV 556
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  565 pplsqvfqtraasadylrpripspigftpgPQQLLGDPFQGMRKPMSPITAQ--MSQLELQQAALEGLALPHDLAVQAAN 642
Cdd:pfam10477 557 ------------------------------IAAVLRECSNGMRNTMSPKPQQnvMTPQSLHQAQLQPLQQPQQLALQQDL 606
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256818796  643 FYQPgfgkpqvdrtrDGFRNRQQRVtkspapvhrGNSSSPAPaasitsmlsPSFTPTSVIRKMYESKEK 711
Cdd:pfam10477 607 FYQN-----------DGNQNRQQHI---------RHSNSPTP---------LAFTPTSVLRKMTADKDK 646
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
748-935 1.63e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  748 DRDSSPT--------TNSKLSALQRSSCSTPLSQANRYTKEQDYRPKATGRKTPTLASPVPTTPflrpvhQVPLVPHVPM 819
Cdd:pfam03154 141 NRSTSPSipspqdneSDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAP------SVPPQGSPAT 214
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  820 VRPAHQLHPGLVQRMLAQ---GVHPQHLPS---LLQTGVLPPGMDLSHLQGISGPILGQPFYPLPAA--SHPLLNPRPGT 891
Cdd:pfam03154 215 SQPPNQTQSTAAPHTLIQqtpTLHPQRLPSphpPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSlqTGPSHMQHPVP 294
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 256818796  892 PLHLAMVQQQLQRSVLHPPgsgSHAAAVSVQTTPQNVPSRSGLP 935
Cdd:pfam03154 295 PQPFPLTPQSSQSQVPPGP---SPAAPGQSQQRIHTPPSQSQLQ 335
 
Name Accession Description Interval E-value
EIF4E-T pfam10477
Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E; EIF4E-T is the transporter ...
30-711 6.71e-162

Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E; EIF4E-T is the transporter protein for shuttling the mRNA cap-binding protein EIF4E protein, targeting it for nuclear import. EIF4E-T contains several key binding domains including two functional leucine-rich NESs (nuclear export signals) between residues 438-447 and 613-638 in the human protein. The other two binding domains are an EIF4E-binding site, between residues 27-42 in Q9EST3, and a bipartite NLS (nuclear localization signals) between 194-211, and these lie in family EIF4E-T_N. EIF4E is the eukaryotic translation initiation factor 4E that is the rate-limiting factor for cap-dependent translation initiation.


Pssm-ID: 371079  Cd Length: 646  Bit Score: 490.29  E-value: 6.71e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796   30 YTKEELLDIKELPHSKQRPSCLSEKY-DSDGVWDPEKWHASLYPASGRSSPVESLKKELDTDRPSLVRRIVDPRERV--- 105
Cdd:pfam10477   1 YSKEDLLALRYEPSSRQRPSCLNRLElQTLGFWDPEKWHSSLYPSNKRSGLVSSRRALRNRERANNYYQRFDPRDRVlgh 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  106 KEDDLDVVLSPQRRSFGGGCH---------VTAAV--SSRRSGSPLEkdsdglrlLGGRRIGSGRII------------- 161
Cdd:pfam10477  81 KESQDDVVLSPQRRSFGGGCHvvpqdheqpVASSPtfSSSREGSPLN--------LQERRIGSGRLLprdyknqpadear 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  162 -------------SARTFEKDHRLSDKDLRD----LRDRDRERDFKDKRFRREFG------------------------- 199
Cdd:pfam10477 153 ierekdrspngsgSSRQDEEDQRNNQQNLRTfsgrHNERGRDGDRRSKRNRRTFGrfqydgkkpvdrgrrisnkdkfsfq 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  200 DSKRVFGERRRNDSYTEEEPEWFSAGPTSQSETIELTGFDDKilEEDHKGRKRTRRRTASVKEGIVECNGGVAEEDEVEV 279
Cdd:pfam10477 233 DRGKRYNSRRRNDSYTEEEPEWFSAGPTSQHETIELHGFDDK--EEDNKRRSRTRVKTESFKELDLECNGGVSEEPESSS 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  280 ILAQEPAADQEVPRDAVLPEQSP-----GDFDFNEFFNLDK-VPCLASMIEDVLGEGSVSASRFSRWFSnpsrsgSRSSS 353
Cdd:pfam10477 311 ILSLNVVEEQESPKKEVLPENSPvnqpeGEFNFDAFLNMDPlDNGLASNDEDVGQEESKGTSRFSRWFG------PNESS 384
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  354 LGSTPHEELERLAGLEQAILSPgqnsgnyfapipledhaenkvDILEMLQKAKVDLKpllsSLSANKEKLKESSHSGVVL 433
Cdd:pfam10477 385 LNNTPHPPLRRESGLQDAIRIP---------------------SVLDLLQKAKVDLR----DLMATKEKLPTSVHSGVVL 439
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  434 SVEEVEAGLkglkvdqqvknstpfmaehleetlsavtnnrqlkkDGDMTAFNKLVSTMKASGTLP--------------- 498
Cdd:pfam10477 440 SVEEVEKGL-----------------------------------DRDTEAFNKLLQQLGSQGTQHhsvndsaptindsna 484
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  499 ----SQPKVSRNLESHLMSPAEIPGQPVP----------KNILQELLGQPVQRPASSNLLSGlmgsleptTSLLGQRAPS 564
Cdd:pfam10477 485 gqlaNQPVPYHIQENHQDQQAKFLGVHTPnifaqpnmeiQHLIQELVRPDISHEFLEKELSN--------PSTLGHTKDV 556
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  565 pplsqvfqtraasadylrpripspigftpgPQQLLGDPFQGMRKPMSPITAQ--MSQLELQQAALEGLALPHDLAVQAAN 642
Cdd:pfam10477 557 ------------------------------IAAVLRECSNGMRNTMSPKPQQnvMTPQSLHQAQLQPLQQPQQLALQQDL 606
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256818796  643 FYQPgfgkpqvdrtrDGFRNRQQRVtkspapvhrGNSSSPAPaasitsmlsPSFTPTSVIRKMYESKEK 711
Cdd:pfam10477 607 FYQN-----------DGNQNRQQHI---------RHSNSPTP---------LAFTPTSVLRKMTADKDK 646
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
748-935 1.63e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  748 DRDSSPT--------TNSKLSALQRSSCSTPLSQANRYTKEQDYRPKATGRKTPTLASPVPTTPflrpvhQVPLVPHVPM 819
Cdd:pfam03154 141 NRSTSPSipspqdneSDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAP------SVPPQGSPAT 214
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  820 VRPAHQLHPGLVQRMLAQ---GVHPQHLPS---LLQTGVLPPGMDLSHLQGISGPILGQPFYPLPAA--SHPLLNPRPGT 891
Cdd:pfam03154 215 SQPPNQTQSTAAPHTLIQqtpTLHPQRLPSphpPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSlqTGPSHMQHPVP 294
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 256818796  892 PLHLAMVQQQLQRSVLHPPgsgSHAAAVSVQTTPQNVPSRSGLP 935
Cdd:pfam03154 295 PQPFPLTPQSSQSQVPPGP---SPAAPGQSQQRIHTPPSQSQLQ 335
 
Name Accession Description Interval E-value
EIF4E-T pfam10477
Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E; EIF4E-T is the transporter ...
30-711 6.71e-162

Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E; EIF4E-T is the transporter protein for shuttling the mRNA cap-binding protein EIF4E protein, targeting it for nuclear import. EIF4E-T contains several key binding domains including two functional leucine-rich NESs (nuclear export signals) between residues 438-447 and 613-638 in the human protein. The other two binding domains are an EIF4E-binding site, between residues 27-42 in Q9EST3, and a bipartite NLS (nuclear localization signals) between 194-211, and these lie in family EIF4E-T_N. EIF4E is the eukaryotic translation initiation factor 4E that is the rate-limiting factor for cap-dependent translation initiation.


Pssm-ID: 371079  Cd Length: 646  Bit Score: 490.29  E-value: 6.71e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796   30 YTKEELLDIKELPHSKQRPSCLSEKY-DSDGVWDPEKWHASLYPASGRSSPVESLKKELDTDRPSLVRRIVDPRERV--- 105
Cdd:pfam10477   1 YSKEDLLALRYEPSSRQRPSCLNRLElQTLGFWDPEKWHSSLYPSNKRSGLVSSRRALRNRERANNYYQRFDPRDRVlgh 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  106 KEDDLDVVLSPQRRSFGGGCH---------VTAAV--SSRRSGSPLEkdsdglrlLGGRRIGSGRII------------- 161
Cdd:pfam10477  81 KESQDDVVLSPQRRSFGGGCHvvpqdheqpVASSPtfSSSREGSPLN--------LQERRIGSGRLLprdyknqpadear 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  162 -------------SARTFEKDHRLSDKDLRD----LRDRDRERDFKDKRFRREFG------------------------- 199
Cdd:pfam10477 153 ierekdrspngsgSSRQDEEDQRNNQQNLRTfsgrHNERGRDGDRRSKRNRRTFGrfqydgkkpvdrgrrisnkdkfsfq 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  200 DSKRVFGERRRNDSYTEEEPEWFSAGPTSQSETIELTGFDDKilEEDHKGRKRTRRRTASVKEGIVECNGGVAEEDEVEV 279
Cdd:pfam10477 233 DRGKRYNSRRRNDSYTEEEPEWFSAGPTSQHETIELHGFDDK--EEDNKRRSRTRVKTESFKELDLECNGGVSEEPESSS 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  280 ILAQEPAADQEVPRDAVLPEQSP-----GDFDFNEFFNLDK-VPCLASMIEDVLGEGSVSASRFSRWFSnpsrsgSRSSS 353
Cdd:pfam10477 311 ILSLNVVEEQESPKKEVLPENSPvnqpeGEFNFDAFLNMDPlDNGLASNDEDVGQEESKGTSRFSRWFG------PNESS 384
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  354 LGSTPHEELERLAGLEQAILSPgqnsgnyfapipledhaenkvDILEMLQKAKVDLKpllsSLSANKEKLKESSHSGVVL 433
Cdd:pfam10477 385 LNNTPHPPLRRESGLQDAIRIP---------------------SVLDLLQKAKVDLR----DLMATKEKLPTSVHSGVVL 439
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  434 SVEEVEAGLkglkvdqqvknstpfmaehleetlsavtnnrqlkkDGDMTAFNKLVSTMKASGTLP--------------- 498
Cdd:pfam10477 440 SVEEVEKGL-----------------------------------DRDTEAFNKLLQQLGSQGTQHhsvndsaptindsna 484
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  499 ----SQPKVSRNLESHLMSPAEIPGQPVP----------KNILQELLGQPVQRPASSNLLSGlmgsleptTSLLGQRAPS 564
Cdd:pfam10477 485 gqlaNQPVPYHIQENHQDQQAKFLGVHTPnifaqpnmeiQHLIQELVRPDISHEFLEKELSN--------PSTLGHTKDV 556
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  565 pplsqvfqtraasadylrpripspigftpgPQQLLGDPFQGMRKPMSPITAQ--MSQLELQQAALEGLALPHDLAVQAAN 642
Cdd:pfam10477 557 ------------------------------IAAVLRECSNGMRNTMSPKPQQnvMTPQSLHQAQLQPLQQPQQLALQQDL 606
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256818796  643 FYQPgfgkpqvdrtrDGFRNRQQRVtkspapvhrGNSSSPAPaasitsmlsPSFTPTSVIRKMYESKEK 711
Cdd:pfam10477 607 FYQN-----------DGNQNRQQHI---------RHSNSPTP---------LAFTPTSVLRKMTADKDK 646
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
748-935 1.63e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  748 DRDSSPT--------TNSKLSALQRSSCSTPLSQANRYTKEQDYRPKATGRKTPTLASPVPTTPflrpvhQVPLVPHVPM 819
Cdd:pfam03154 141 NRSTSPSipspqdneSDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAP------SVPPQGSPAT 214
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818796  820 VRPAHQLHPGLVQRMLAQ---GVHPQHLPS---LLQTGVLPPGMDLSHLQGISGPILGQPFYPLPAA--SHPLLNPRPGT 891
Cdd:pfam03154 215 SQPPNQTQSTAAPHTLIQqtpTLHPQRLPSphpPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSlqTGPSHMQHPVP 294
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 256818796  892 PLHLAMVQQQLQRSVLHPPgsgSHAAAVSVQTTPQNVPSRSGLP 935
Cdd:pfam03154 295 PQPFPLTPQSSQSQVPPGP---SPAAPGQSQQRIHTPPSQSQLQ 335
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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