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Conserved domains on  [gi|255652930|ref|NP_001157391|]
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zinc finger protein 960 isoform 2 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 9.97e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 9.97e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 255652930   13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIG 53
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
128-283 6.10e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 6.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652930 128 KVYDGNQCGKTFSCHNHFE--IRKGTYTGE--KPYEC--NQCGKAFARHSNLLDHKRIHTGEKPYKCK--QCGKDFT--- 196
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTrhLRSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652930 197 ---HHSTLHIHKRIHTREKTY----KCNQ-CMTIAHLQCHKITHTGEKPYACK--KCGKTFAYHKTLQIHERTHTGEKLY 266
Cdd:COG5048  368 nnePPQSLQQYKDLKNDKKSEtlsnSCIRnFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*..
gi 255652930 267 QCNQCakaFPYHRTLQI 283
Cdd:COG5048  448 LCSIL---KSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-305 5.27e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.27e-04
                          10        20
                  ....*....|....*....|....*
gi 255652930  281 LQIHERTHTGEKPYECNQCGKAFAC 305
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
308-333 1.68e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 255652930  308 NLQNHKTTHTGEKPYECNQCGRAFRQ 333
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 9.97e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 9.97e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 255652930   13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIG 53
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
13-54 4.06e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 80.33  E-value: 4.06e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 255652930    13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIGY 54
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-50 1.66e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.58  E-value: 1.66e-16
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 255652930  13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLT 50
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
128-283 6.10e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 6.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652930 128 KVYDGNQCGKTFSCHNHFE--IRKGTYTGE--KPYEC--NQCGKAFARHSNLLDHKRIHTGEKPYKCK--QCGKDFT--- 196
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTrhLRSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652930 197 ---HHSTLHIHKRIHTREKTY----KCNQ-CMTIAHLQCHKITHTGEKPYACK--KCGKTFAYHKTLQIHERTHTGEKLY 266
Cdd:COG5048  368 nnePPQSLQQYKDLKNDKKSEtlsnSCIRnFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*..
gi 255652930 267 QCNQCakaFPYHRTLQI 283
Cdd:COG5048  448 LCSIL---KSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
172-197 2.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.45e-04
                          10        20
                  ....*....|....*....|....*.
gi 255652930  172 NLLDHKRIHTGEKPYKCKQCGKDFTH 197
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-305 5.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.27e-04
                          10        20
                  ....*....|....*....|....*
gi 255652930  281 LQIHERTHTGEKPYECNQCGKAFAC 305
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
308-333 1.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 255652930  308 NLQNHKTTHTGEKPYECNQCGRAFRQ 333
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 9.97e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 9.97e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 255652930   13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIG 53
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
13-54 4.06e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 80.33  E-value: 4.06e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 255652930    13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIGY 54
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-50 1.66e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.58  E-value: 1.66e-16
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 255652930  13 VTYYDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLT 50
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
128-283 6.10e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 6.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652930 128 KVYDGNQCGKTFSCHNHFE--IRKGTYTGE--KPYEC--NQCGKAFARHSNLLDHKRIHTGEKPYKCK--QCGKDFT--- 196
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTrhLRSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652930 197 ---HHSTLHIHKRIHTREKTY----KCNQ-CMTIAHLQCHKITHTGEKPYACK--KCGKTFAYHKTLQIHERTHTGEKLY 266
Cdd:COG5048  368 nnePPQSLQQYKDLKNDKKSEtlsnSCIRnFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*..
gi 255652930 267 QCNQCakaFPYHRTLQI 283
Cdd:COG5048  448 LCSIL---KSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
172-197 2.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.45e-04
                          10        20
                  ....*....|....*....|....*.
gi 255652930  172 NLLDHKRIHTGEKPYKCKQCGKDFTH 197
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-209 3.44e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 3.44e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 255652930 156 KPYECNQCGKAFARHSNLLDHKRIHTGEKPYKCKQCGKD--FTHHSTLHIHKRIHT 209
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-305 5.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.27e-04
                          10        20
                  ....*....|....*....|....*
gi 255652930  281 LQIHERTHTGEKPYECNQCGKAFAC 305
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-333 6.46e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 6.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652930 156 KPYECNQCGKAFARHSNLLDHKR--IHTGE--KPYKC--KQCGKDFTHHSTLHIHKRIHT--REKTYKCNQCMTiahlqc 227
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTsiSPAKEKLLNSSS------ 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652930 228 hkiTHTGEKPyackkcGKTFAYHKTLQIHERTHTGEKLYqcNQCAKAFPYHRTLQIHERTHTGEKPYECN--QCGKAFAC 305
Cdd:COG5048  362 ---KFSPLLN------NEPPQSLQQYKDLKNDKKSETLS--NSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                        170       180
                 ....*....|....*....|....*...
gi 255652930 306 LRNLQNHKTTHTGEKPYECNQCGRAFRQ 333
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
308-333 1.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 255652930  308 NLQNHKTTHTGEKPYECNQCGRAFRQ 333
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 182-261 5.48e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.55  E-value: 5.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255652930 182 GEKPYKCK--QCGKDFTHHSTLHIHKrihtrektyKCNQCMTIAHLQCHKITHTG----EKPYACKKCGKTFAYHKTLQI 255
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIfsakDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 255652930 256 HeRTHT 261
Cdd:COG5189  417 H-RKHS 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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