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Conserved domains on  [gi|251823944|ref|NP_001156536|]
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uncharacterized protein LOC216177 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 5.77e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.90  E-value: 5.77e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 251823944    4 VTYEDVHVNFTHEEWVLLDPSQKSLYKDVMLETYWNLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
144-497 3.79e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.43  E-value: 3.79e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 144 PSRNSLQIHNRthtgekPYDCNECGKAFTCSSNLLLHKRTHTGEKPYDCSD--CGKAFASSSNLQIHKRKHTGEKPYGCN 221
Cdd:COG5048   22 STLKSLSNAPR------PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 222 QCGKAFAYSNALQKHERSH-TREKIYECNQCGKAFARHRSLQNHEEHHTLEKPYECSQCGKAFA---------------- 284
Cdd:COG5048   96 KSLPLSNSKASSSSLSSSSsNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnslhpplpans 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 285 ------YSSNLYIHERSHTGEKPFKCTQCGKAFPSHSSLQIHERTHTGEKPYDCNECGKAFACRSNLLLHKRTHTGEKPY 358
Cdd:COG5048  176 lskdpsSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 359 HCIECGKAFACSSSLQKHEKTHTGE-------KPYECNQCGKAFARRSDLYIHER--IHTGE--KPYEC--NQCGKAFVH 425
Cdd:COG5048  256 SASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSR 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 426 CISLQRHERTHTGEKPYEC--NQCGKAFT-----RRFSLQVHERSHSGEKPYEC--NQCGKAFASRSSLRYHRKHHTAKK 496
Cdd:COG5048  336 NDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFR 415


                 .
gi 251823944 497 P 497
Cdd:COG5048  416 P 416
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 5.77e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.90  E-value: 5.77e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 251823944    4 VTYEDVHVNFTHEEWVLLDPSQKSLYKDVMLETYWNLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.41e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 1.41e-17
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 251823944   4 VTYEDVHVNFTHEEWVLLDPSQKSLYKDVMLETYWNLT 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
KRAB smart00349
krueppel associated box;
4-47 4.70e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 4.70e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 251823944     4 VTYEDVHVNFTHEEWVLLDPSQKSLYKDVMLETYWNLTAIGYKL 47
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQV 44
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
144-497 3.79e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.43  E-value: 3.79e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 144 PSRNSLQIHNRthtgekPYDCNECGKAFTCSSNLLLHKRTHTGEKPYDCSD--CGKAFASSSNLQIHKRKHTGEKPYGCN 221
Cdd:COG5048   22 STLKSLSNAPR------PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 222 QCGKAFAYSNALQKHERSH-TREKIYECNQCGKAFARHRSLQNHEEHHTLEKPYECSQCGKAFA---------------- 284
Cdd:COG5048   96 KSLPLSNSKASSSSLSSSSsNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnslhpplpans 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 285 ------YSSNLYIHERSHTGEKPFKCTQCGKAFPSHSSLQIHERTHTGEKPYDCNECGKAFACRSNLLLHKRTHTGEKPY 358
Cdd:COG5048  176 lskdpsSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 359 HCIECGKAFACSSSLQKHEKTHTGE-------KPYECNQCGKAFARRSDLYIHER--IHTGE--KPYEC--NQCGKAFVH 425
Cdd:COG5048  256 SASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSR 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 426 CISLQRHERTHTGEKPYEC--NQCGKAFT-----RRFSLQVHERSHSGEKPYEC--NQCGKAFASRSSLRYHRKHHTAKK 496
Cdd:COG5048  336 NDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFR 415


                 .
gi 251823944 497 P 497
Cdd:COG5048  416 P 416
zf-H2C2_2 pfam13465
Zinc-finger double domain;
428-453 1.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.19e-04
                          10        20
                  ....*....|....*....|....*.
gi 251823944  428 SLQRHERTHTGEKPYECNQCGKAFTR 453
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 5.77e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.90  E-value: 5.77e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 251823944    4 VTYEDVHVNFTHEEWVLLDPSQKSLYKDVMLETYWNLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.41e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 1.41e-17
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 251823944   4 VTYEDVHVNFTHEEWVLLDPSQKSLYKDVMLETYWNLT 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
KRAB smart00349
krueppel associated box;
4-47 4.70e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 4.70e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 251823944     4 VTYEDVHVNFTHEEWVLLDPSQKSLYKDVMLETYWNLTAIGYKL 47
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQV 44
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
144-497 3.79e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.43  E-value: 3.79e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 144 PSRNSLQIHNRthtgekPYDCNECGKAFTCSSNLLLHKRTHTGEKPYDCSD--CGKAFASSSNLQIHKRKHTGEKPYGCN 221
Cdd:COG5048   22 STLKSLSNAPR------PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 222 QCGKAFAYSNALQKHERSH-TREKIYECNQCGKAFARHRSLQNHEEHHTLEKPYECSQCGKAFA---------------- 284
Cdd:COG5048   96 KSLPLSNSKASSSSLSSSSsNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnslhpplpans 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 285 ------YSSNLYIHERSHTGEKPFKCTQCGKAFPSHSSLQIHERTHTGEKPYDCNECGKAFACRSNLLLHKRTHTGEKPY 358
Cdd:COG5048  176 lskdpsSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 359 HCIECGKAFACSSSLQKHEKTHTGE-------KPYECNQCGKAFARRSDLYIHER--IHTGE--KPYEC--NQCGKAFVH 425
Cdd:COG5048  256 SASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSR 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 426 CISLQRHERTHTGEKPYEC--NQCGKAFT-----RRFSLQVHERSHSGEKPYEC--NQCGKAFASRSSLRYHRKHHTAKK 496
Cdd:COG5048  336 NDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFR 415


                 .
gi 251823944 497 P 497
Cdd:COG5048  416 P 416
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
134-343 2.85e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 2.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 134 YECNHCGKSFPSRNSLQIHNRTHTG-EKPYDCNECGKAFTCSSNLLLHKRT--HTGE--KPYDC--SDCGKAFASSSNLQ 206
Cdd:COG5048  261 PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALK 340

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 207 IHKRKHTGEKPYGCNqcgkafaysnaLQKHERSHTREKIYEcnqcgkafarHRSLQNHEEHHTLEKPYEC--SQCGKAFA 284
Cdd:COG5048  341 RHILLHTSISPAKEK-----------LLNSSSKFSPLLNNE----------PPQSLQQYKDLKNDKKSETlsNSCIRNFK 399

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 251823944 285 YSSNLYIHERSHTGEKP--FKCTQCGKAFPSHSSLQIHERTHTGEKPYDCNECGKAFACRS 343
Cdd:COG5048  400 RDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 438-493 1.36e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.41  E-value: 1.36e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 251823944 438 GEKPYECN--QCGKAFTRRFSLQVH---------------ERSHSG----EKPYECNQCGKAFASRSSLRYHRKHHT 493
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
104-489 1.40e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 104 KPYECKQCSQIFTNFCHLRKHEKKHTKEKLYECNH--CGKSFPSRNSLQIHNRTHTGEKPYDCN--ECGKAFTCSSNLLL 179
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSksLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 180 HKRTHTgEKPYDCSDCGKAFAS--------SSNLQIHKRKHTGEKPYGCN---------------QCGKAFAYSNALQKH 236
Cdd:COG5048  112 SSSSNS-NDNNLLSSHSLPPSSrdpqlpdlLSISNLRNNPLPGNNSSSVNtpqsnslhpplpansLSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 237 ERSHTREKIYECNQCGKAFARHRSLQNHEEHHTLEkPYECSQCGKAFAYSSNLYIHERSHTGEKPFKCTQCG------KA 310
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 311 FPSHSSLQIHERTHTG-EKPYDCNECGKAFACRSNLLLHKRT--HTGE--KPYHC--IECGKAFACSSSLQKHEKTHTGE 383
Cdd:COG5048  270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 384 KPYEC--NQCGKAF------ARRSDLYIHERIHTgEKPYEC--NQCGKAFVHCISLQRHERTHTGEKPYECN--QCGKAF 451
Cdd:COG5048  350 SPAKEklLNSSSKFspllnnEPPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 251823944 452 TRRFSLQVHERSHSGEKPYECNQCGKAFASRSSLRYHR 489
Cdd:COG5048  429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
428-453 1.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.19e-04
                          10        20
                  ....*....|....*....|....*.
gi 251823944  428 SLQRHERTHTGEKPYECNQCGKAFTR 453
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
372-397 4.80e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.80e-04
                          10        20
                  ....*....|....*....|....*.
gi 251823944  372 SLQKHEKTHTGEKPYECNQCGKAFAR 397
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
344-369 5.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.84e-04
                          10        20
                  ....*....|....*....|....*.
gi 251823944  344 NLLLHKRTHTGEKPYHCIECGKAFAC 369
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
456-481 1.95e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.95e-03
                          10        20
                  ....*....|....*....|....*.
gi 251823944  456 SLQVHERSHSGEKPYECNQCGKAFAS 481
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
316-341 2.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.09e-03
                          10        20
                  ....*....|....*....|....*.
gi 251823944  316 SLQIHERTHTGEKPYDCNECGKAFAC 341
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
288-311 2.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.20e-03
                          10        20
                  ....*....|....*....|....
gi 251823944  288 NLYIHERSHTGEKPFKCTQCGKAF 311
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
400-425 2.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.24e-03
                          10        20
                  ....*....|....*....|....*.
gi 251823944  400 DLYIHERIHTGEKPYECNQCGKAFVH 425
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
176-201 4.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.04e-03
                          10        20
                  ....*....|....*....|....*.
gi 251823944  176 NLLLHKRTHTGEKPYDCSDCGKAFAS 201
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
148-173 5.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.76e-03
                          10        20
                  ....*....|....*....|....*.
gi 251823944  148 SLQIHNRTHTGEKPYDCNECGKAFTC 173
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
204-229 6.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.23e-03
                          10        20
                  ....*....|....*....|....*.
gi 251823944  204 NLQIHKRKHTGEKPYGCNQCGKAFAY 229
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
232-257 8.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 251823944  232 ALQKHERSHTREKIYECNQCGKAFAR 257
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 186-270 9.15e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.55  E-value: 9.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823944 186 GEKPYDCS--DCGKAFASSSNLQIHkRKHtgekpygcNQCGKAFAYSNALQKHERSHTREKIYECNQCGKAFARHRSLQN 263
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*..
gi 251823944 264 HEEHHTL 270
Cdd:COG5189  417 HRKHSHD 423
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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