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Conserved domains on  [gi|247269852|ref|NP_001156012|]
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serine/threonine-protein kinase 32C isoform 2 [Mus musculus]

Protein Classification

serine/threonine-protein kinase( domain architecture ID 10144970)

serine/threonine-protein kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
STKc_Yank1 cd05578
Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the ...
1-234 8.93e-142

Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily contains uncharacterized STKs with similarity to the human protein designated as Yank1 or STK32A. The Yank1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


:

Pssm-ID: 270730 [Multi-domain]  Cd Length: 257  Bit Score: 402.79  E-value: 8.93e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05578   27 MFAMKYMNKQKCIEKDSVRNVLNELEILQELEHPFLVNLWYSFQDEEDMYMVVDLLLGGDLRYHLQQKVKFSEETVKFYI 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEVD 160
Cdd:cd05578  107 CEIVLALDYLHSKNIIHRDIKPDNILLDEQGHVHITDFNIATKLTDGTLATSTSGTKPYMAPEVFMR-----AGYSFAVD 181
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 247269852 161 WWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQTAP 234
Cdd:cd05578  182 WWSLGVTAYEMLRGKRPYEIHSRTSIEEIRAKFETASVLYPAGWSEEAIDLINKLLERDPQKRLGDLSDLKNHP 255
 
Name Accession Description Interval E-value
STKc_Yank1 cd05578
Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the ...
1-234 8.93e-142

Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily contains uncharacterized STKs with similarity to the human protein designated as Yank1 or STK32A. The Yank1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270730 [Multi-domain]  Cd Length: 257  Bit Score: 402.79  E-value: 8.93e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05578   27 MFAMKYMNKQKCIEKDSVRNVLNELEILQELEHPFLVNLWYSFQDEEDMYMVVDLLLGGDLRYHLQQKVKFSEETVKFYI 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEVD 160
Cdd:cd05578  107 CEIVLALDYLHSKNIIHRDIKPDNILLDEQGHVHITDFNIATKLTDGTLATSTSGTKPYMAPEVFMR-----AGYSFAVD 181
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 247269852 161 WWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQTAP 234
Cdd:cd05578  182 WWSLGVTAYEMLRGKRPYEIHSRTSIEEIRAKFETASVLYPAGWSEEAIDLINKLLERDPQKRLGDLSDLKNHP 255
S_TKc smart00220
Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or ...
2-231 1.16e-75

Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or threonine-specific kinase subfamily.


Pssm-ID: 214567 [Multi-domain]  Cd Length: 254  Bit Score: 234.35  E-value: 1.16e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852     2 YAMKYMNKQQciERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:smart00220  27 VAIKVIKKKK--IKKDRERILREIKILKKLKHPNIVRLYDVFEDEDKLYLVMEYCEGGDLFDLLKKRGRLSEDEARFYLR 104
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852    82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFEVDW 161
Cdd:smart00220 105 QILSALEYLHSKGIVHRDLKPENILLDEDGHVKLADFGLARQLDPGEKLTTFVGTPEYMAPEVLL-----GKGYGKAVDI 179
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 247269852   162 WSVGVMAYELLRGWRPYDihSSNAVESLVQLFSTVSVQ---YVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:smart00220 180 WSLGVILYELLTGKPPFP--GDDQLLELFKKIGKPKPPfppPEWDISPEAKDLIRKLLVKDPEKRLTAEEALQ 250
PTZ00263 PTZ00263
protein kinase A catalytic subunit; Provisional
2-251 9.23e-51

protein kinase A catalytic subunit; Provisional


Pssm-ID: 140289 [Multi-domain]  Cd Length: 329  Bit Score: 172.69  E-value: 9.23e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:PTZ00263  46 YAIKCLKKREILKMKQVQHVAQEKSILMELSHPFIVNMMCSFQDENRVYFLLEFVVGGELFTHLRKAGRFPNDVAKFYHA 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDgeRATALAGTKPYMAPEIFHSfvnggTGYSFEVDW 161
Cdd:PTZ00263 126 ELVLAFEYLHSKDIIYRDLKPENLLLDNKGHVKVTDFGFAKKVPD--RTFTLCGTPEYLAPEVIQS-----KGHGKAVDW 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 162 WSVGVMAYELLRGWRP-YDihssnavESLVQLFSTVSVQYV--PTWSKEMVA-LLRKLLTVNPEHRFSSL----QDMQTA 233
Cdd:PTZ00263 199 WTMGVLLYEFIAGYPPfFD-------DTPFRIYEKILAGRLkfPNWFDGRARdLVKGLLQTDHTKRLGTLkggvADVKNH 271
                        250
                 ....*....|....*...
gi 247269852 234 PSLAHVLWDDLSEKKVEP 251
Cdd:PTZ00263 272 PYFHGANWDKLYARYYPA 289
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
2-233 1.65e-46

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 165.19  E-value: 1.65e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:COG0515   35 VALKVLRPELAADPEARERFRREARALARLNHPNIVRVYDVGEEDGRPYLVMEYVEGESLADLLRRRGPLPPAEALRILA 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE--RATALAGTKPYMAPEIFHsfvngGTGYSFEV 159
Cdd:COG0515  115 QLAEALAAAHAAGIVHRDIKPANILLTPDGRVKLIDFGIARALGGATltQTGTVVGTPGYMAPEQAR-----GEPVDPRS 189
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 247269852 160 DWWSVGVMAYELLRGWRPYDIHSSNAV-ESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQTA 233
Cdd:COG0515  190 DVYSLGVTLYELLTGRPPFDGDSPAELlRAHLREPPPPPSELRPDLPPALDAIVLRALAKDPEERYQSAAELAAA 264
Pkinase pfam00069
Protein kinase domain;
1-231 2.01e-37

Protein kinase domain;


Pssm-ID: 459660 [Multi-domain]  Cd Length: 217  Bit Score: 134.29  E-value: 2.01e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852    1 MYAMKYMNKQQcIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:pfam00069  26 IVAIKKIKKEK-IKKKKDKNILREIKILKKLNHPNIVRLYDAFEDKDNLYLVLEYVEGGSLFDLLSEKGAFSEREAKFIM 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   81 CEMALALDYlrsqhiihrdvkpdnilldeqghahltdfniatiikdGERATALAGTKPYMAPEIFhsfvnGGTGYSFEVD 160
Cdd:pfam00069 105 KQILEGLES-------------------------------------GSSLTTFVGTPWYMAPEVL-----GGNPYGPKVD 142
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 247269852  161 WWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:pfam00069 143 VWSLGCILYELLTGKPPFPGINGNEIYELIIDQPYAFPELPSNLSEEAKDLLKKLLKKDPSKRLTATQALQ 213
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
44-230 1.68e-14

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 74.83  E-value: 1.68e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  44 QDEEDM--FMV---VDlllGGDLRYHLQQNVQFS-EDTVRLYIcEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTD 117
Cdd:NF033483  75 VGEDGGipYIVmeyVD---GRTLKDYIREHGPLSpEEAVEIMI-QILSALEHAHRNGIVHRDIKPQNILITKDGRVKVTD 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 118 FNIAtiikdgeRA---------TALAGTKPYMAPE-IFHSFVNggtgysFEVDWWSVGVMAYELLRGWRPYDIHSsnAVE 187
Cdd:NF033483 151 FGIA-------RAlssttmtqtNSVLGTVHYLSPEqARGGTVD------ARSDIYSLGIVLYEMLTGRPPFDGDS--PVS 215
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 247269852 188 SLVQLFS--TVSV-QYVPTWSKEMVALLRKLLTVNPEHRFSSLQDM 230
Cdd:NF033483 216 VAYKHVQedPPPPsELNPGIPQSLDAVVLKATAKDPDDRYQSAAEM 261
BREX_PglW NF033442
BREX system serine/threonine kinase PglW; Members of this family are PglW, a predicted serine ...
86-233 1.55e-08

BREX system serine/threonine kinase PglW; Members of this family are PglW, a predicted serine/threonine kinase of the Pgl (phage growth limitation) system (now called BREX type 2) and the BREX type 3 system.


Pssm-ID: 468028 [Multi-domain]  Cd Length: 1387  Bit Score: 56.50  E-value: 1.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   86 ALDYLRSQHIIHRDVKPDNILLDEQG----HAHLTDFNIAtiiKDGERATAlAGTKPYMAPeifhsFVNGGT--GYSFEV 159
Cdd:NF033442  619 AVVHLEGQGVWHRDIKPDNIGIRPRPsrtlHLVLFDFSLA---GAPADNIE-AGTPGYLDP-----FLGTGTrpRYDDAA 689
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852  160 DWWSVGVMAYELLRGWRP-YDIHSSNA--VESLVQLFSTVsvqYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQTA 233
Cdd:NF033442  690 ERYAAAVTLYEMATGTLPvWGDGQVDPatLDDEVTLDAEA---FDPAVRDGLVAFFRRALARDARDRFDTAEDMRRA 763
 
Name Accession Description Interval E-value
STKc_Yank1 cd05578
Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the ...
1-234 8.93e-142

Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily contains uncharacterized STKs with similarity to the human protein designated as Yank1 or STK32A. The Yank1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270730 [Multi-domain]  Cd Length: 257  Bit Score: 402.79  E-value: 8.93e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05578   27 MFAMKYMNKQKCIEKDSVRNVLNELEILQELEHPFLVNLWYSFQDEEDMYMVVDLLLGGDLRYHLQQKVKFSEETVKFYI 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEVD 160
Cdd:cd05578  107 CEIVLALDYLHSKNIIHRDIKPDNILLDEQGHVHITDFNIATKLTDGTLATSTSGTKPYMAPEVFMR-----AGYSFAVD 181
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 247269852 161 WWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQTAP 234
Cdd:cd05578  182 WWSLGVTAYEMLRGKRPYEIHSRTSIEEIRAKFETASVLYPAGWSEEAIDLINKLLERDPQKRLGDLSDLKNHP 255
STKc_AGC cd05123
Catalytic domain of AGC family Serine/Threonine Kinases; STKs catalyze the transfer of the ...
1-227 1.17e-94

Catalytic domain of AGC family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. AGC kinases regulate many cellular processes including division, growth, survival, metabolism, motility, and differentiation. Many are implicated in the development of various human diseases. Members of this family include cAMP-dependent Protein Kinase (PKA), cGMP-dependent Protein Kinase (PKG), Protein Kinase C (PKC), Protein Kinase B (PKB), G protein-coupled Receptor Kinase (GRK), Serum- and Glucocorticoid-induced Kinase (SGK), and 70 kDa ribosomal Protein S6 Kinase (p70S6K or S6K), among others. AGC kinases share an activation mechanism based on the phosphorylation of up to three sites: the activation loop (A-loop), the hydrophobic motif (HM) and the turn motif. Phosphorylation at the A-loop is required of most AGC kinases, which results in a disorder-to-order transition of the A-loop. The ordered conformation results in the access of substrates and ATP to the active site. A subset of AGC kinases with C-terminal extensions containing the HM also requires phosphorylation at this site. Phosphorylation at the HM allows the C-terminal extension to form an ordered structure that packs into the hydrophobic pocket of the catalytic domain, which then reconfigures the kinase into an active bi-lobed state. In addition, growth factor-activated AGC kinases such as PKB, p70S6K, RSK, MSK, PKC, and SGK, require phosphorylation at the turn motif (also called tail or zipper site), located N-terminal to the HM at the C-terminal extension. The AGC family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and Phosphoinositide 3-Kinase.


Pssm-ID: 270693 [Multi-domain]  Cd Length: 250  Bit Score: 282.48  E-value: 1.17e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05123   20 LYAMKVLRKKEIIKRKEVEHTLNERNILERVNHPFIVKLHYAFQTEEKLYLVLDYVPGGELFSHLSKEGRFPEERARFYA 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAT-IIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFEV 159
Cdd:cd05123  100 AEIVLALEYLHSLGIIYRDLKPENILLDSDGHIKLTDFGLAKeLSSDGDRTYTFCGTPEYLAPEVLL-----GKGYGKAV 174
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 160 DWWSVGVMAYELLRGWRPYdiHSSNAVEsLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSL 227
Cdd:cd05123  175 DWWSLGVLLYEMLTGKPPF--YAENRKE-IYEKILKSPLKFPEYVSPEAKSLISGLLQKDPTKRLGSG 239
S_TKc smart00220
Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or ...
2-231 1.16e-75

Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or threonine-specific kinase subfamily.


Pssm-ID: 214567 [Multi-domain]  Cd Length: 254  Bit Score: 234.35  E-value: 1.16e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852     2 YAMKYMNKQQciERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:smart00220  27 VAIKVIKKKK--IKKDRERILREIKILKKLKHPNIVRLYDVFEDEDKLYLVMEYCEGGDLFDLLKKRGRLSEDEARFYLR 104
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852    82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFEVDW 161
Cdd:smart00220 105 QILSALEYLHSKGIVHRDLKPENILLDEDGHVKLADFGLARQLDPGEKLTTFVGTPEYMAPEVLL-----GKGYGKAVDI 179
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 247269852   162 WSVGVMAYELLRGWRPYDihSSNAVESLVQLFSTVSVQ---YVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:smart00220 180 WSLGVILYELLTGKPPFP--GDDQLLELFKKIGKPKPPfppPEWDISPEAKDLIRKLLVKDPEKRLTAEEALQ 250
STKc_PKA_like cd05580
Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases; STKs ...
2-255 2.62e-66

Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the cAMP-dependent protein kinases, PKA and PRKX, and similar proteins. The inactive PKA holoenzyme is a heterotetramer composed of two phosphorylated and active catalytic subunits with a dimer of regulatory (R) subunits. Activation is achieved through the binding of the important second messenger cAMP to the R subunits, which leads to the dissociation of PKA into the R dimer and two active subunits. PKA is present ubiquitously in cells and interacts with many different downstream targets. It plays a role in the regulation of diverse processes such as growth, development, memory, metabolism, gene expression, immunity, and lipolysis. PRKX is also reulated by the R subunit and is is present in many tissues including fetal and adult brain, kidney, and lung. It is implicated in granulocyte/macrophage lineage differentiation, renal cell epithelial migration, and tubular morphogenesis in the developing kidney. The PKA-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270732 [Multi-domain]  Cd Length: 290  Bit Score: 211.67  E-value: 2.62e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd05580   29 YALKILKKAKIIKLKQVEHVLNEKRILSEVRHPFIVNLLGSFQDDRNLYMVMEYVPGGELFSLLRRSGRFPNDVAKFYAA 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDgeRATALAGTKPYMAPEIFHSfvnggTGYSFEVDW 161
Cdd:cd05580  109 EVVLALEYLHSLDIVYRDLKPENLLLDSDGHIKITDFGFAKRVKD--RTYTLCGTPEYLAPEIILS-----KGHGKAVDW 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 162 WSVGVMAYELLRGWRP-YDIHSSNAVESLVQLFstvsVQYVPTWSKEMVALLRKLLTVNPEHRFSSL----QDMQTAPSL 236
Cdd:cd05580  182 WALGILIYEMLAGYPPfFDENPMKIYEKILEGK----IRFPSFFDPDAKDLIKRLLVVDLTKRLGNLkngvEDIKNHPWF 257
                        250
                 ....*....|....*....
gi 247269852 237 AHVLWDDLSEKKVEPGFVP 255
Cdd:cd05580  258 AGIDWDALLQRKIPAPYVP 276
STKc_PKC cd05570
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C; STKs catalyze the transfer ...
1-273 2.75e-66

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, classical PKCs depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. Novel PKCs are calcium-independent, but require DAG and PS for activity, while atypical PKCs only require PS. PKCs phosphorylate and modify the activities of a wide variety of cellular proteins including receptors, enzymes, cytoskeletal proteins, transcription factors, and other kinases. They play a central role in signal transduction pathways that regulate cell migration and polarity, proliferation, differentiation, and apoptosis. Also included in this subfamily are the PKC-like proteins, called PKNs. The PKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270722 [Multi-domain]  Cd Length: 318  Bit Score: 212.46  E-value: 2.75e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEIL-QEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLY 79
Cdd:cd05570   22 LYAIKVLKKEVIIEDDDVECTMTEKRVLaLANRHPFLTGLHACFQTEDRLYFVMEYVNGGDLMFHIQRARRFTEERARFY 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHsfvngGTGYSFE 158
Cdd:cd05570  102 AAEICLALQFLHERGIIYRDLKLDNVLLDAEGHIKIADFGMCKEgIWGGNTTSTFCGTPDYIAPEILR-----EQDYGFS 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDIhssnavESLVQLFSTVS---VQYVPTWSKEMVALLRKLLTVNPEHRFSSL----QDMQ 231
Cdd:cd05570  177 VDWWALGVLLYEMLAGQSPFEG------DDEDELFEAILndeVLYPRWLSREAVSILKGLLTKDPARRLGCGpkgeADIK 250
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 247269852 232 TAPSLAHVLWDDLSEKKVEPGFVPN-KGRLHC---DPTFELEEMIL 273
Cdd:cd05570  251 AHPFFRNIDWDKLEKKEVEPPFKPKvKSPRDTsnfDPEFTSESPRL 296
STKc_ROCK_NDR_like cd05573
Catalytic domain of Rho-associated coiled-coil containing protein kinase (ROCK)- and Nuclear ...
2-255 2.10e-61

Catalytic domain of Rho-associated coiled-coil containing protein kinase (ROCK)- and Nuclear Dbf2-Related (NDR)-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily include ROCK and ROCK-like proteins such as DMPK, MRCK, and CRIK, as well as NDR and NDR-like proteins such as LATS, CBK1 and Sid2p. ROCK and CRIK are effectors of the small GTPase Rho, while MRCK is an effector of the small GTPase Cdc42. NDR and NDR-like kinases contain an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Proteins in this subfamily are involved in regulating many cellular functions including contraction, motility, division, proliferation, apoptosis, morphogenesis, and cytokinesis. The ROCK/NDR-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270725 [Multi-domain]  Cd Length: 350  Bit Score: 200.97  E-value: 2.10e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd05573   29 YAMKILRKSDMLKREQIAHVRAERDILADADSPWIVRLHYAFQDEDHLYLVMEYMPGGDLMNLLIKYDVFPEETARFYIA 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAT-IIKDGER-----------------------------AT 131
Cdd:cd05573  109 ELVLALDSLHKLGFIHRDIKPDNILLDADGHIKLADFGLCTkMNKSGDResylndsvntlfqdnvlarrrphkqrrvrAY 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 132 ALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLRGWRPYdihSSnavESLVQLFSTV-----SVQY--VPTW 204
Cdd:cd05573  189 SAVGTPDYIAPEVLR-----GTGYGPECDWWSLGVILYEMLYGFPPF---YS---DSLVETYSKImnwkeSLVFpdDPDV 257
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 247269852 205 SKEMVALLRKLLTvNPEHRFSSLQDMQTAPSLAHVLWDDLSEKKvePGFVP 255
Cdd:cd05573  258 SPEAIDLIRRLLC-DPEDRLGSAEEIKAHPFFKGIDWENLRESP--PPFVP 305
STKc_RSK_N cd05582
N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase; ...
1-266 4.35e-61

N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. Mammals possess four RSK isoforms (RSK1-4) from distinct genes. RSK proteins are also referred to as MAP kinase-activated protein kinases (MAPKAPKs), p90-RSKs, or p90S6Ks. The RSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270734 [Multi-domain]  Cd Length: 317  Bit Score: 199.16  E-value: 4.35e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFrELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05582   25 LYAMKVLKKATLKVRDRVRTKM-ERDILADVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYL 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAT-IIKDGERATALAGTKPYMAPEIfhsfVNgGTGYSFEV 159
Cdd:cd05582  104 AELALALDHLHSLGIIYRDLKPENILLDEDGHIKLTDFGLSKeSIDHEKKAYSFCGTVEYMAPEV----VN-RRGHTQSA 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 160 DWWSVGVMAYELLRGWRPYdiHSSNAVESLVQ-LFSTVSV-QYVptwSKEMVALLRKLLTVNPEHRFSS----LQDMQTA 233
Cdd:cd05582  179 DWWSFGVLMFEMLTGSLPF--QGKDRKETMTMiLKAKLGMpQFL---SPEAQSLLRALFKRNPANRLGAgpdgVEEIKRH 253
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 247269852 234 PSLAHVLWDDLSEKKVEPGFVPNKGR----LHCDPTF 266
Cdd:cd05582  254 PFFATIDWNKLYRKEIKPPFKPAVSRpddtFYFDPEF 290
STKc_MAST_like cd05579
Catalytic domain of Microtubule-associated serine/threonine (MAST) kinase-like proteins; STKs ...
1-223 5.63e-61

Catalytic domain of Microtubule-associated serine/threonine (MAST) kinase-like proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes MAST kinases, MAST-like (MASTL) kinases (also called greatwall kinase or Gwl), and fungal kinases with similarity to Saccharomyces cerevisiae Rim15 and Schizosaccharomyces pombe cek1. MAST kinases contain an N-terminal domain of unknown function, a central catalytic domain, and a C-terminal PDZ domain that mediates protein-protein interactions. MASTL kinases carry only a catalytic domain which contains a long insert relative to other kinases. The fungal kinases in this subfamily harbor other domains in addition to a central catalytic domain, which like in MASTL, also contains an insert relative to MAST kinases. Rim15 contains a C-terminal signal receiver (REC) domain while cek1 contains an N-terminal PAS domain. MAST kinases are cytoskeletal associated kinases of unknown function that are also expressed at neuromuscular junctions and postsynaptic densities. MASTL/Gwl is involved in the regulation of mitotic entry, mRNA stabilization, and DNA checkpoint recovery. The fungal proteins Rim15 and cek1 are involved in the regulation of meiosis and mitosis, respectively. The MAST-like kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270731 [Multi-domain]  Cd Length: 272  Bit Score: 197.05  E-value: 5.63e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLrYHLQQNV-QFSEDTVRLY 79
Cdd:cd05579   20 LYAIKVIKKRDMIRKNQVDSVLAERNILSQAQNPFVVKLYYSFQGKKNLYLVMEYLPGGDL-YSLLENVgALDEDVARIY 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDF----------------NIATIIKDGERATALAGTKPYMAPE 143
Cdd:cd05579   99 IAEIVLALEYLHSHGIIHRDLKPDNILIDANGHLKLTDFglskvglvrrqiklsiQKKSNGAPEKEDRRIVGTPDYLAPE 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 144 IFHsfvngGTGYSFEVDWWSVGVMAYELLRGWRPYdiHSSNAVEslvqLFSTVsVQYVPTW------SKEMVALLRKLLT 217
Cdd:cd05579  179 ILL-----GQGHGKTVDWWSLGVILYEFLVGIPPF--HAETPEE----IFQNI-LNGKIEWpedpevSDEAKDLISKLLT 246

                 ....*.
gi 247269852 218 VNPEHR 223
Cdd:cd05579  247 PDPEKR 252
STKc_cGK cd05572
Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG); ...
1-228 3.32e-57

Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mammals have two cGK isoforms from different genes, cGKI and cGKII. cGKI exists as two splice variants, cGKI-alpha and cGKI-beta. cGK consists of an N-terminal regulatory domain containing a dimerization and an autoinhibitory pseudosubstrate region, two cGMP-binding domains, and a C-terminal catalytic domain. Binding of cGMP to both binding sites releases the inhibition of the catalytic center by the pseudosubstrate region, allowing autophosphorylation and activation of the kinase. cGKI is a soluble protein expressed in all smooth muscles, platelets, cerebellum, and kidney. It is also expressed at lower concentrations in other tissues. cGKII is a membrane-bound protein that is most abundantly expressed in the intestine. It is also present in the brain nuclei, adrenal cortex, kidney, lung, and prostate. cGKI is involved in the regulation of smooth muscle tone, smooth cell proliferation, and platelet activation. cGKII plays a role in the regulation of secretion, such as renin secretion by the kidney and aldosterone secretion by the adrenal. It also regulates bone growth and the circadian rhythm. The cGK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270724 [Multi-domain]  Cd Length: 262  Bit Score: 187.05  E-value: 3.32e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05572   20 TFALKCVKKRHIVQTRQQEHIFSEKEILEECNSPFIVKLYRTFKDKKYLYMLMEYCLGGELWTILRDRGLFDEYTARFYT 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFEVD 160
Cdd:cd05572  100 ACVVLAFEYLHSRGIIYRDLKPENLLLDSNGYVKLVDFGFAKKLGSGRKTWTFCGTPEYVAPEIIL-----NKGYDFSVD 174
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 161 WWSVGVMAYELLRGWRPY--DIHSSNAVESLVqLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd05572  175 YWSLGILLYELLTGRPPFggDDEDPMKIYNII-LKGIDKIEFPKYIDKNAKNLIKQLLRRNPEERLGYLK 243
STKc_Aurora cd14007
Catalytic domain of the Serine/Threonine kinase, Aurora kinase; STKs catalyze the transfer of ...
2-234 1.18e-55

Catalytic domain of the Serine/Threonine kinase, Aurora kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Yeast contains only one Aurora kinase while most higher eukaryotes have two. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). Aurora-A regulates cell cycle events from the late S-phase through the M-phase including centrosome maturation, mitotic entry, centrosome separation, spindle assembly, chromosome alignment, cytokinesis, and mitotic exit. Aurora-A activation depends on its autophosphorylation and binding to the microtubule-associated protein TPX2. Aurora-B is most active at the transition during metaphase to the end of mitosis. It is critical for accurate chromosomal segregation, cytokinesis, protein localization to the centrosome and kinetochore, correct microtubule-kinetochore attachments, and regulation of the mitotic checkpoint. Aurora-C is mainly expressed in meiotically dividing cells; it was originally discovered in mice as a testis-specific STK called Aie1. Both Aurora-B and -C are chromosomal passenger proteins that can form complexes with INCENP and survivin, and they may have redundant cellular functions. The Aurora subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270909 [Multi-domain]  Cd Length: 253  Bit Score: 182.67  E-value: 1.18e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd14007   28 VALKVISKSQLQKSGLEHQLRREIEIQSHLRHPNILRLYGYFEDKKRIYLILEYAPNGELYKELKKQKRFDEKEAAKYIY 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATaLAGTKPYMAPEIFHsfvngGTGYSFEVDW 161
Cdd:cd14007  108 QLALALDYLHSKNIIHRDIKPENILLGSNGELKLADFGWSVHAPSNRRKT-FCGTLDYLPPEMVE-----GKEYDYKVDI 181
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 247269852 162 WSVGVMAYELLRGWRPYDIHSSNAVESLVQlfsTVSVQYVPTWSKEMVALLRKLLTVNPEHRFsSLQDMQTAP 234
Cdd:cd14007  182 WSLGVLCYELLVGKPPFESKSHQETYKRIQ---NVDIKFPSSVSPEAKDLISKLLQKDPSKRL-SLEQVLNHP 250
STKc_PKB cd05571
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B; STKs catalyze the transfer ...
2-256 2.51e-55

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. There are three PKB isoforms from different genes, PKB-alpha (or Akt1), PKB-beta (or Akt2), and PKB-gamma (or Akt3). PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. It is activated downstream of phosphoinositide 3-kinase (PI3K) and plays important roles in diverse cellular functions including cell survival, growth, proliferation, angiogenesis, motility, and migration. PKB also has a central role in a variety of human cancers, having been implicated in tumor initiation, progression, and metastasis. The PKB subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and PI3K.


Pssm-ID: 270723 [Multi-domain]  Cd Length: 322  Bit Score: 184.10  E-value: 2.51e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd05571   23 YAIKILKKEVIIAKDEVAHTLTENRVLQNTRHPFLTSLKYSFQTNDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGA 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEVD 160
Cdd:cd05571  103 EIVLALGYLHSQGIVYRDLKLENLLLDKDGHIKITDFGLCKEeISYGATTKTFCGTPEYLAPEVLED-----NDYGRAVD 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 161 WWSVGVMAYELLRGWRPYdihSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRF----SSLQDMQTAPSL 236
Cdd:cd05571  178 WWGLGVVMYEMMCGRLPF---YNRDHEVLFELILMEEVRFPSTLSPEAKSLLAGLLKKDPKKRLgggpRDAKEIMEHPFF 254
                        250       260
                 ....*....|....*....|
gi 247269852 237 AHVLWDDLSEKKVEPGFVPN 256
Cdd:cd05571  255 ASINWDDLYQKKIPPPFKPQ 274
STKc_PKA cd14209
Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase; STKs catalyze ...
2-256 3.73e-55

Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The inactive PKA holoenzyme is a heterotetramer composed of two phosphorylated and active catalytic subunits with a dimer of regulatory (R) subunits. Activation is achieved through the binding of the important second messenger cAMP to the R subunits, which leads to the dissociation of PKA into the R dimer and two active subunits. PKA is present ubiquitously in cells and interacts with many different downstream targets. It plays a role in the regulation of diverse processes such as growth, development, memory, metabolism, gene expression, immunity, and lipolysis. The PKA subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271111 [Multi-domain]  Cd Length: 290  Bit Score: 182.60  E-value: 3.73e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd14209   29 YAMKILDKQKVVKLKQVEHTLNEKRILQAINFPFLVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDgeRATALAGTKPYMAPEIFHSfvnggTGYSFEVDW 161
Cdd:cd14209  109 QIVLAFEYLHSLDLIYRDLKPENLLIDQQGYIKVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILS-----KGYNKAVDW 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 162 WSVGVMAYELLRGWRPYDIHSSnaveslVQLFSTV---SVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQ----DMQTAP 234
Cdd:cd14209  182 WALGVLIYEMAAGYPPFFADQP------IQIYEKIvsgKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKngvnDIKNHK 255
                        250       260
                 ....*....|....*....|..
gi 247269852 235 SLAHVLWDDLSEKKVEPGFVPN 256
Cdd:cd14209  256 WFATTDWIAIYQRKVEAPFIPK 277
STKc_GRK cd05577
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase; STKs ...
1-256 1.88e-54

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. GRKs play important roles in the cardiovascular, immune, respiratory, skeletal, and nervous systems. They contain a central catalytic domain, flanked by N- and C-terminal extensions. The N-terminus contains an RGS (regulator of G protein signaling) homology (RH) domain and several motifs. The C-terminus diverges among different groups of GRKs. There are seven types of GRKs, named GRK1 to GRK7, which are subdivided into three main groups: visual (GRK1/7); beta-adrenergic receptor kinases (GRK2/3); and GRK4-like (GRK4/5/6). Expression of GRK2/3/5/6 is widespread while GRK1/4/7 show a limited tissue distribution. The substrate spectrum of the widely expressed GRKs partially overlaps. The GRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270729 [Multi-domain]  Cd Length: 278  Bit Score: 180.42  E-value: 1.88e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQ--FSEDTVRL 78
Cdd:cd05577   20 MYACKKLDKKRIKKKKGETMALNEKIILEKVSSPFIVSLAYAFETKDKLCLVLTLMNGGDLKYHIYNVGTrgFSEARAIF 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIfhsfVNGGTGYSFE 158
Cdd:cd05577  100 YAAEIICGLEHLHNRFIVYRDLKPENILLDDHGHVRISDLGLAVEFKGGKKIKGRVGTHGYMAPEV----LQKEVAYDFS 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDIHSSN-AVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSL----QDMQTA 233
Cdd:cd05577  176 VDWFALGCMLYEMIAGRSPFRQRKEKvDKEELKRRTLEMAVEYPDSFSPEARSLCEGLLQKDPERRLGCRggsaDEVKEH 255
                        250       260
                 ....*....|....*....|...
gi 247269852 234 PSLAHVLWDDLSEKKVEPGFVPN 256
Cdd:cd05577  256 PFFRSLNWQRLEAGMLEPPFVPD 278
STKc_SGK cd05575
Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase; ...
2-266 3.07e-54

Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGKs are activated by insulin and growth factors via phosphoinositide 3-kinase and PDK1. They activate ion channels, ion carriers, and the Na-K-ATPase, as well as regulate the activity of enzymes and transcription factors. SGKs play important roles in transport, hormone release, neuroexcitability, cell proliferation, and apoptosis. There are three isoforms of SGK, named SGK1, SGK2, and SGK3 (also called cytokine-independent survival kinase CISK). The SGK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270727 [Multi-domain]  Cd Length: 323  Bit Score: 181.36  E-value: 3.07e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEIL-QEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05575   23 YAVKVLQKKAILKRNEVKHIMAERNVLlKNVKHPFLVGLHYSFQTKDKLYFVLDYVNGGELFFHLQRERHFPEPRARFYA 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEV 159
Cdd:cd05575  103 AEIASALGYLHSLNIIYRDLKPENILLDSQGHVVLTDFGLCKEgIEPSDTTSTFCGTPEYLAPEVLRK-----QPYDRTV 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 160 DWWSVGVMAYELLRGWRP---------YDihssNAVESLVQLFSTVSVqyvptwskEMVALLRKLLTVNPEHRFSSLQD- 229
Cdd:cd05575  178 DWWCLGAVLYEMLYGLPPfysrdtaemYD----NILHKPLRLRTNVSP--------SARDLLEGLLQKDRTKRLGSGNDf 245
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 247269852 230 --MQTAPSLAHVLWDDLSEKKVEPGFVPN-KGRL---HCDPTF 266
Cdd:cd05575  246 leIKNHSFFRPINWDDLEAKKIPPPFNPNvSGPLdlrNIDPEF 288
STKc_nPKC_theta_like cd05592
Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and ...
2-273 1.80e-53

Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. There are four nPKC isoforms, delta, epsilon, eta, and theta. The nPKC-theta-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270744 [Multi-domain]  Cd Length: 320  Bit Score: 179.50  E-value: 1.80e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQ-EIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05592   23 FAIKALKKDVVLEDDDVECTMIERRVLAlASQHPFLTHLFCTFQTESHLFFVMEYLNGGDLMFHIQQSGRFDEDRARFYG 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIA-TIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFEV 159
Cdd:cd05592  103 AEIICGLQFLHSRGIIYRDLKLDNVLLDREGHIKIADFGMCkENIYGENKASTFCGTPDYIAPEILK-----GQKYNQSV 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 160 DWWSVGVMAYELLRGWRPYdiHSSNAVEslvqLFSTVSVQ--YVPTW-SKEMVALLRKLLTVNPEHRF----SSLQDMQT 232
Cdd:cd05592  178 DWWSFGVLLYEMLIGQSPF--HGEDEDE----LFWSICNDtpHYPRWlTKEAASCLSLLLERNPEKRLgvpeCPAGDIRD 251
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 247269852 233 APSLAHVLWDDLSEKKVEPGFVPN-KGRLHC---DPTFELEEMIL 273
Cdd:cd05592  252 HPFFKTIDWDKLERREIDPPFKPKvKSANDVsnfDPDFTMEKPVL 296
STKc_NDR_like cd05599
Catalytic domain of Nuclear Dbf2-Related kinase-like Protein Serine/Threonine Kinases; STKs ...
2-256 8.17e-53

Catalytic domain of Nuclear Dbf2-Related kinase-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NDR kinases regulate mitosis, cell growth, embryonic development, and neurological processes. They are also required for proper centrosome duplication. Higher eukaryotes contain two NDR isoforms, NDR1 and NDR2. This subfamily also contains fungal NDR-like kinases. NDR kinase contains an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Like many other AGC kinases, NDR kinase requires phosphorylation at two sites, the activation loop (A-loop) and the hydrophobic motif (HM), for activity. The NDR kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270750 [Multi-domain]  Cd Length: 324  Bit Score: 177.81  E-value: 8.17e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd05599   29 YAMKKLRKSEMLEKEQVAHVRAERDILAEADNPWVVKLYYSFQDEENLYLIMEFLPGGDMMTLLMKKDTLTEEETRFYIA 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEVDW 161
Cdd:cd05599  109 ETVLAIESIHKLGYIHRDIKPDNLLLDARGHIKLSDFGLCTGLKKSHLAYSTVGTPDYIAPEVFLQ-----KGYGKECDW 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 162 WSVGVMAYELLRGWRPYdiHSSNAVESLVQLFSTVSVQYVPT---WSKEMVALLRKLLTvNPEHR--FSSLQDMQTAPSL 236
Cdd:cd05599  184 WSLGVIMYEMLIGYPPF--CSDDPQETCRKIMNWRETLVFPPevpISPEAKDLIERLLC-DAEHRlgANGVEEIKSHPFF 260
                        250       260
                 ....*....|....*....|
gi 247269852 237 AHVLWDDLSEKKvePGFVPN 256
Cdd:cd05599  261 KGVDWDHIRERP--APILPE 278
STKc_MSK_N cd05583
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
1-223 1.20e-52

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, in response to various stimuli such as growth factors, hormones, neurotransmitters, cellular stress, and pro-inflammatory cytokines. This triggers phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) in the C-terminal extension of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. MSKs are predominantly nuclear proteins. They are widely expressed in many tissues including heart, brain, lung, liver, kidney, and pancreas. There are two isoforms of MSK, called MSK1 and MSK2. The MSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270735 [Multi-domain]  Cd Length: 268  Bit Score: 175.66  E-value: 1.20e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFR-ELEILQEIEHV-FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRL 78
Cdd:cd05583   24 LYAMKVLKKATIVQKAKTAEHTMtERQVLEAVRQSpFLVTLHYAFQTDAKLHLILDYVNGGELFTHLYQREHFTESEVRI 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATII--KDGERATALAGTKPYMAPEIFHSfvnGGTGYS 156
Cdd:cd05583  104 YIGEIVLALEHLHKLGIIYRDIKLENILLDSEGHVVLTDFGLSKEFlpGENDRAYSFCGTIEYMAPEVVRG---GSDGHD 180
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 157 FEVDWWSVGVMAYELLRGWRPYDIH-SSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHR 223
Cdd:cd05583  181 KAVDWWSLGVLTYELLTGASPFTVDgERNSQSEISKRILKSHPPIPKTFSAEAKDFILKLLEKDPKKR 248
STKc_MSK1_N cd05613
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
1-255 3.18e-52

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK1 plays a role in the regulation of translational control and transcriptional activation. It phosphorylates the transcription factors, CREB and NFkB. It also phosphorylates the nucleosomal proteins H3 and HMG-14. Increased phosphorylation of MSK1 is associated with the development of cerebral ischemic/hypoxic preconditioning. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270764 [Multi-domain]  Cd Length: 290  Bit Score: 175.19  E-value: 3.18e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFR-ELEILQEIEHV-FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRL 78
Cdd:cd05613   30 LYAMKVLKKATIVQKAKTAEHTRtERQVLEHIRQSpFLVTLHYAFQTDTKLHLILDYINGGELFTHLSQRERFTENEVQI 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAT--IIKDGERATALAGTKPYMAPEIfhsfVNGG-TGY 155
Cdd:cd05613  110 YIGEIVLALEHLHKLGIIYRDIKLENILLDSSGHVVLTDFGLSKefLLDENERAYSFCGTIEYMAPEI----VRGGdSGH 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 156 SFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVqlfSTVSVQYVPTWSKEMVAL----LRKLLTVNPEHRFSS----L 227
Cdd:cd05613  186 DKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEI---SRRILKSEPPYPQEMSALakdiIQRLLMKDPKKRLGCgpngA 262
                        250       260
                 ....*....|....*....|....*...
gi 247269852 228 QDMQTAPSLAHVLWDDLSEKKVEPGFVP 255
Cdd:cd05613  263 DEIKKHPFFQKINWDDLAAKKVPAPFKP 290
STKc_SGK3 cd05604
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced ...
2-256 3.40e-52

Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK3 (also called cytokine-independent survival kinase or CISK) is expressed in most tissues and is most abundant in the embryo and adult heart and spleen. It was originally discovered in a screen for antiapoptotic genes. It phosphorylates and inhibits the proapoptotic proteins, Bad and FKHRL1. SGK3 also regulates many transporters, ion channels, and receptors. It plays a critical role in hair follicle morphogenesis and hair cycling. The SGK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270755 [Multi-domain]  Cd Length: 326  Bit Score: 176.31  E-value: 3.40e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEIL-QEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05604   24 YAVKVLQKKVILNRKEQKHIMAERNVLlKNVKHPFLVGLHYSFQTTDKLYFVLDFVNGGELFFHLQRERSFPEPRARFYA 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEV 159
Cdd:cd05604  104 AEIASALGYLHSINIVYRDLKPENILLDSQGHIVLTDFGLCKEgISNSDTTTTFCGTPEYLAPEVIRK-----QPYDNTV 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 160 DWWSVGVMAYELLRGWRPY---DIHS--SNAVESLVQLFSTVSvqyVPTWSkemvaLLRKLLTVNPEHRF---SSLQDMQ 231
Cdd:cd05604  179 DWWCLGSVLYEMLYGLPPFycrDTAEmyENILHKPLVLRPGIS---LTAWS-----ILEELLEKDRQLRLgakEDFLEIK 250
                        250       260
                 ....*....|....*....|....*
gi 247269852 232 TAPSLAHVLWDDLSEKKVEPGFVPN 256
Cdd:cd05604  251 NHPFFESINWTDLVQKKIPPPFNPN 275
STKc_CAMK cd05117
The catalytic domain of CAMK family Serine/Threonine Kinases; STKs catalyze the transfer of ...
2-228 8.35e-52

The catalytic domain of CAMK family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. CaMKII is a signaling molecule that translates upstream calcium and reactive oxygen species (ROS) signals into downstream responses that play important roles in synaptic function and cardiovascular physiology. CAMKIV is implicated in regulating several transcription factors like CREB, MEF2, and retinoid orphan receptors, as well as in T-cell development and signaling. The CAMK family also consists of other related kinases including the Phosphorylase kinase Gamma subunit (PhKG), the C-terminal kinase domains of Ribosomal S6 kinase (RSK) and Mitogen and stress-activated kinase (MSK), Doublecortin-like kinase (DCKL), and the MAPK-activated protein kinases MK2, MK3, and MK5, among others. The CAMK family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270687 [Multi-domain]  Cd Length: 258  Bit Score: 173.05  E-value: 8.35e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEvRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd05117   28 YAVKIIDKKKLKSEDE-EMLRREIEILKRLDHPNIVKLYEVFEDDKNLYLVMELCTGGELFDRIVKKGSFSEREAAKIMK 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAH---LTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFE 158
Cdd:cd05117  107 QILSAVAYLHSQGIVHRDLKPENILLASKDPDSpikIIDFGLAKIFEEGEKLKTVCGTPYYVAPEVLK-----GKGYGKK 181
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQlfstvSVQYV---PTW---SKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd05117  182 CDIWSLGVILYILLCGYPPFYGETEQELFEKIL-----KGKYSfdsPEWknvSEEAKDLIKRLLVVDPKKRLTAAE 252
STKc_SGK2 cd05603
Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2; ...
2-275 9.56e-52

Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK2 shows a more restricted distribution than SGK1 and is most abundantly expressed in epithelial tissues including kidney, liver, pancreas, and the choroid plexus of the brain. In vitro cellular assays show that SGK2 can stimulate the activity of ion channels, the glutamate transporter EEAT4, and the glutamate receptors, GluR6 and GLUR1. The SGK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270754 [Multi-domain]  Cd Length: 321  Bit Score: 174.77  E-value: 9.56e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEIL-QEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05603   23 YAVKVLQKKTILKKKEQNHIMAERNVLlKNLKHPFLVGLHYSFQTSEKLYFVLDYVNGGELFFHLQRERCFLEPRARFYA 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAtiiKDG----ERATALAGTKPYMAPEIFHSfvnggTGYS 156
Cdd:cd05603  103 AEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLC---KEGmepeETTSTFCGTPEYLAPEVLRK-----EPYD 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 157 FEVDWWSVGVMAYELLRGWRPYdihSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQTAPSl 236
Cdd:cd05603  175 RTVDWWCLGAVLYEMLYGLPPF---YSRDVSQMYDNILHKPLHLPGGKTVAACDLLQGLLHKDQRRRLGAKADFLEIKN- 250
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 247269852 237 aHVL-----WDDLSEKKVEPGFVPN---KGRL-HCDPTFElEEMILES 275
Cdd:cd05603  251 -HVFfspinWDDLYHKRITPPYNPNvagPADLrHFDPEFT-QEAVPHS 296
STKc_MSK2_N cd05614
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
1-255 4.15e-51

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK2 and MSK1 play nonredundant roles in activating histone H3 kinases, which play pivotal roles in compaction of the chromatin fiber. MSK2 is the required H3 kinase in response to stress stimuli and activation of the p38 MAPK pathway. MSK2 also plays a role in the pathogenesis of psoriasis. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family, similar to 90 kDa ribosomal protein S6 kinases (RSKs). MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270765 [Multi-domain]  Cd Length: 332  Bit Score: 173.57  E-value: 4.15e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFR-ELEILQEI-EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRL 78
Cdd:cd05614   30 LYAMKVLRKAALVQKAKTVEHTRtERNVLEHVrQSPFLVTLHYAFQTDAKLHLILDYVSGGELFTHLYQRDHFSEDEVRF 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAT--IIKDGERATALAGTKPYMAPEIfhsfVNGGTGYS 156
Cdd:cd05614  110 YSGEIILALEHLHKLGIVYRDIKLENILLDSEGHVVLTDFGLSKefLTEEKERTYSFCGTIEYMAPEI----IRGKSGHG 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 157 FEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLV-QLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSS----LQDMQ 231
Cdd:cd05614  186 KAVDWWSLGILMFELLTGASPFTLEGEKNTQSEVsRRILKCDPPFPSFIGPVARDLLQKLLCKDPKKRLGAgpqgAQEIK 265
                        250       260
                 ....*....|....*....|....
gi 247269852 232 TAPSLAHVLWDDLSEKKVEPGFVP 255
Cdd:cd05614  266 EHPFFKGLDWEALALRKVNPPFRP 289
STKc_Sck1_like cd05586
Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Serine/Threonine ...
1-256 5.29e-51

Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Sck1 and similar fungal proteins. Sck1 plays a role in trehalase activation triggered by glucose and a nitrogen source. Trehalase catalyzes the cleavage of the disaccharide trehalose to glucose. Trehalose, as a carbohydrate reserve and stress metabolite, plays an important role in the response of yeast to environmental changes. The Sck1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270738 [Multi-domain]  Cd Length: 330  Bit Score: 173.14  E-value: 5.29e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEI---EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVR 77
Cdd:cd05586   20 IYAMKVLSKKVIVAKKEVAHTIGERNILVRTaldESPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFSEDRAK 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  78 LYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHSfvngGTGYS 156
Cdd:cd05586  100 FYIAELVLALEHLHKNDIVYRDLKPENILLDANGHIALCDFGLSKAdLTDNKTTNTFCGTTEYLAPEVLLD----EKGYT 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 157 FEVDWWSVGVMAYELLRGWRPYdihSSNAVESLVQLFSTVSVQYVP-TWSKEMVALLRKLLTVNPEHRFSSLQD---MQT 232
Cdd:cd05586  176 KMVDFWSLGVLVFEMCCGWSPF---YAEDTQQMYRNIAFGKVRFPKdVLSDEGRSFVKGLLNRNPKHRLGAHDDaveLKE 252
                        250       260
                 ....*....|....*....|....
gi 247269852 233 APSLAHVLWDDLSEKKVEPGFVPN 256
Cdd:cd05586  253 HPFFADIDWDLLSKKKITPPFKPI 276
PTZ00263 PTZ00263
protein kinase A catalytic subunit; Provisional
2-251 9.23e-51

protein kinase A catalytic subunit; Provisional


Pssm-ID: 140289 [Multi-domain]  Cd Length: 329  Bit Score: 172.69  E-value: 9.23e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:PTZ00263  46 YAIKCLKKREILKMKQVQHVAQEKSILMELSHPFIVNMMCSFQDENRVYFLLEFVVGGELFTHLRKAGRFPNDVAKFYHA 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDgeRATALAGTKPYMAPEIFHSfvnggTGYSFEVDW 161
Cdd:PTZ00263 126 ELVLAFEYLHSKDIIYRDLKPENLLLDNKGHVKVTDFGFAKKVPD--RTFTLCGTPEYLAPEVIQS-----KGHGKAVDW 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 162 WSVGVMAYELLRGWRP-YDihssnavESLVQLFSTVSVQYV--PTWSKEMVA-LLRKLLTVNPEHRFSSL----QDMQTA 233
Cdd:PTZ00263 199 WTMGVLLYEFIAGYPPfFD-------DTPFRIYEKILAGRLkfPNWFDGRARdLVKGLLQTDHTKRLGTLkggvADVKNH 271
                        250
                 ....*....|....*...
gi 247269852 234 PSLAHVLWDDLSEKKVEP 251
Cdd:PTZ00263 272 PYFHGANWDKLYARYYPA 289
STKc_PKB_beta cd05595
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2); ...
2-255 9.74e-51

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-beta is the predominant PKB isoform expressed in insulin-responsive tissues. It plays a critical role in the regulation of glucose homeostasis. It is also implicated in muscle cell differentiation. Mice deficient in PKB-beta display normal growth weights but exhibit severe insulin resistance and diabetes, accompanied by lipoatrophy and B-cell failure. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain.The PKB-beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173686 [Multi-domain]  Cd Length: 323  Bit Score: 172.50  E-value: 9.74e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd05595   23 YAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGA 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEVD 160
Cdd:cd05595  103 EIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEgITDGATMKTFCGTPEYLAPEVLED-----NDYGRAVD 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 161 WWSVGVMAYELLRGWRPYdihSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRF----SSLQDMQTAPSL 236
Cdd:cd05595  178 WWGLGVVMYEMMCGRLPF---YNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLgggpSDAKEVMEHRFF 254
                        250
                 ....*....|....*....
gi 247269852 237 AHVLWDDLSEKKVEPGFVP 255
Cdd:cd05595  255 LSINWQDVVQKKLLPPFKP 273
STKc_p70S6K cd05584
Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase; STKs ...
2-256 1.34e-50

Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p70S6K (or S6K) contains only one catalytic kinase domain, unlike p90 ribosomal S6 kinases (RSKs). It acts as a downstream effector of the STK mTOR (mammalian Target of Rapamycin) and plays a role in the regulation of the translation machinery during protein synthesis. p70S6K also plays a pivotal role in regulating cell size and glucose homeostasis. Its targets include S6, the translation initiation factor eIF3, and the insulin receptor substrate IRS-1, among others. Mammals contain two isoforms of p70S6K, named S6K1 and S6K2 (or S6K-beta). The p70S6K subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270736 [Multi-domain]  Cd Length: 323  Bit Score: 171.82  E-value: 1.34e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCI--ERDEV-----RNvfreleILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSED 74
Cdd:cd05584   27 FAMKVLKKASIVrnQKDTAhtkaeRN------ILEAVKHPFIVDLHYAFQTGGKLYLILEYLSGGELFMHLEREGIFMED 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  75 TVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAT-IIKDGERATALAGTKPYMAPEIFHSfvnggT 153
Cdd:cd05584  101 TACFYLAEITLALGHLHSLGIIYRDLKPENILLDAQGHVKLTDFGLCKeSIHDGTVTHTFCGTIEYMAPEILTR-----S 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 154 GYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVqLFSTVSVqyVPTWSKEMVALLRKLLTVNPEHRFSSLQD---- 229
Cdd:cd05584  176 GHGKAVDWWSLGALMYDMLTGAPPFTAENRKKTIDKI-LKGKLNL--PPYLTNEARDLLKKLLKRNVSSRLGSGPGdaee 252
                        250       260
                 ....*....|....*....|....*..
gi 247269852 230 MQTAPSLAHVLWDDLSEKKVEPGFVPN 256
Cdd:cd05584  253 IKAHPFFRHINWDDLLAKKVEPPFKPL 279
STKc_AMPK-like cd14003
Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases; STKs catalyze ...
2-234 9.58e-50

Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The AMPK-like subfamily is composed of AMPK, MARK, BRSK, NUAK, MELK, SNRK, TSSK, and SIK, among others. LKB1 serves as a master upstream kinase that activates AMPK and most AMPK-like kinases. AMPK, also called SNF1 (sucrose non-fermenting1) in yeasts and SnRK1 (SNF1-related kinase1) in plants, is a heterotrimeric enzyme composed of a catalytic alpha subunit and two regulatory subunits, beta and gamma. It is a stress-activated kinase that serves as master regulator of glucose and lipid metabolism by monitoring carbon and energy supplies, via sensing the cell's AMP:ATP ratio. MARKs phosphorylate tau and related microtubule-associated proteins (MAPs), and regulates microtubule-based intracellular transport. They are involved in embryogenesis, epithelial cell polarization, cell signaling, and neuronal differentiation. BRSKs play important roles in establishing neuronal polarity. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. The AMPK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270905 [Multi-domain]  Cd Length: 252  Bit Score: 167.31  E-value: 9.58e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQcIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd14003   28 VAIKIIDKSK-LKEEIEEKIKREIEIMKLLNHPNIIKLYEVIETENKIYLVMEYASGGELFDYIVNNGRLSEDEARRFFQ 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTGY-SFEVD 160
Cdd:cd14003  107 QLISAVDYCHSNGIVHRDLKLENILLDKNGNLKIIDFGLSNEFRGGSLLKTFCGTPAYAAPEVLL-----GRKYdGPKAD 181
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 161 WWSVGVMAYELLRGWRPYDIHSSNAVESLVqlfstVSVQY-VPTW-SKEMVALLRKLLTVNPEHRFsSLQDMQTAP 234
Cdd:cd14003  182 VWSLGVILYAMLTGYLPFDDDNDSKLFRKI-----LKGKYpIPSHlSPDARDLIRRMLVVDPSKRI-TIEEILNHP 251
STKc_LATS cd05598
Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor; STKs catalyze the ...
1-256 1.73e-49

Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LATS was originally identified in Drosophila using a screen for genes whose inactivation led to overproliferation of cells. In tetrapods, there are two LATS isoforms, LATS1 and LATS2. Inactivation of LATS1 in mice results in the development of various tumors, including sarcomas and ovarian cancer. LATS functions as a tumor suppressor and is implicated in cell cycle regulation. The LATS subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270749 [Multi-domain]  Cd Length: 333  Bit Score: 169.42  E-value: 1.73e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05598   28 LYAMKTLRKKDVLKRNQVAHVKAERDILAEADNEWVVKLYYSFQDKENLYFVMDYIPGGDLMSLLIKKGIFEEDLARFYI 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATiikdGER---------ATALAGTKPYMAPEIFHSfvng 151
Cdd:cd05598  108 AELVCAIESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCT----GFRwthdskyylAHSLVGTPNYIAPEVLLR---- 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 152 gTGYSFEVDWWSVGVMAYELLRGWRPYdiHSSNAVES---LVQLFSTVSVQYVPTWSKEMVALLRKLLTvNPEHRFSS-- 226
Cdd:cd05598  180 -TGYTQLCDWWSVGVILYEMLVGQPPF--LAQTPAETqlkVINWRTTLKIPHEANLSPEAKDLILRLCC-DAEDRLGRng 255
                        250       260       270
                 ....*....|....*....|....*....|
gi 247269852 227 LQDMQTAPSLAHVLWDDLseKKVEPGFVPN 256
Cdd:cd05598  256 ADEIKAHPFFAGIDWEKL--RKQKAPYIPT 283
STKc_PknB_like cd14014
Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins; STKs ...
2-230 1.02e-48

Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270916 [Multi-domain]  Cd Length: 260  Bit Score: 165.07  E-value: 1.02e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd14014   28 VAIKVLRPELAEDEEFRERFLREARALARLSHPNIVRVYDVGEDDGRPYIVMEYVEGGSLADLLRERGPLPPREALRILA 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE--RATALAGTKPYMAPEIFHsfvngGTGYSFEV 159
Cdd:cd14014  108 QIADALAAAHRAGIVHRDIKPANILLTEDGRVKLTDFGIARALGDSGltQTGSVLGTPAYMAPEQAR-----GGPVDPRS 182
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 247269852 160 DWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSV-QYVPTWSKEMVALLRKLLTVNPEHRFSSLQDM 230
Cdd:cd14014  183 DIYSLGVVLYELLTGRPPFDGDSPAAVLAKHLQEAPPPPsPLNPDVPPALDAIILRALAKDPEERPQSAAEL 254
STKc_GRK4_like cd05605
Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases; STKs ...
1-256 1.34e-48

Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of the GRK4-like group include GRK4, GRK5, GRK6, and similar GRKs. They contain an N-terminal RGS homology (RH) domain and a catalytic domain, but lack a G protein betagamma-subunit binding domain. They are localized to the plasma membrane through post-translational lipid modification or direct binding to PIP2. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK4-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270756 [Multi-domain]  Cd Length: 285  Bit Score: 165.61  E-value: 1.34e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ--NVQFSEDTVRL 78
Cdd:cd05605   27 MYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNmgNPGFEEERAVF 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEifhsfVNGGTGYSFE 158
Cdd:cd05605  107 YAAEITCGLEHLHSERIVYRDLKPENILLDDHGHVRISDLGLAVEIPEGETIRGRVGTVGYMAPE-----VVKNERYTFS 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDIH----SSNAVESLVQlfsTVSVQYVPTWSKEMVALLRKLLTVNPEHRF----SSLQDM 230
Cdd:cd05605  182 PDWWGLGCLIYEMIEGQAPFRARkekvKREEVDRRVK---EDQEEYSEKFSEEAKSICSQLLQKDPKTRLgcrgEGAEDV 258
                        250       260
                 ....*....|....*....|....*.
gi 247269852 231 QTAPSLAHVLWDDLSEKKVEPGFVPN 256
Cdd:cd05605  259 KSHPFFKSINFKRLEAGLLEPPFVPD 284
STKc_nPKC_eta cd05590
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta; STKs catalyze the ...
1-273 1.55e-48

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-eta is predominantly expressed in squamous epithelia, where it plays a crucial role in the signaling of cell-type specific differentiation. It is also expressed in pro-B cells and early-stage thymocytes, and acts as a key regulator in early B-cell development. PKC-eta increases glioblastoma multiforme (GBM) proliferation and resistance to radiation, and is being developed as a therapeutic target for the management of GBM. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-eta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270742 [Multi-domain]  Cd Length: 323  Bit Score: 166.62  E-value: 1.55e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQ-EIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLY 79
Cdd:cd05590   22 LYAVKVLKKDVILQDDDVECTMTEKRILSlARNHPFLTQLYCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFY 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHSFVnggtgYSFE 158
Cdd:cd05590  102 AAEITSALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEgIFNGKTTSTFCGTPDYIAPEILQEML-----YGPS 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDIHSSNaveslvQLFSTV---SVQYvPTW-SKEMVALLRKLLTVNPEHRFSSLQDMQTAP 234
Cdd:cd05590  177 VDWWAMGVLLYEMLCGHAPFEAENED------DLFEAIlndEVVY-PTWlSQDAVDILKAFMTKNPTMRLGSLTLGGEEA 249
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 247269852 235 SLAHVL-----WDDLSEKKVEPGFVPN-KGR---LHCDPTFELEEMIL 273
Cdd:cd05590  250 ILRHPFfkeldWEKLNRRQIEPPFRPRiKSRedvSNFDPDFIKEDPVL 297
STKc_PDK1 cd05581
Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; STKs ...
1-238 4.10e-48

Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PDK1 carries an N-terminal catalytic domain and a C-terminal pleckstrin homology (PH) domain that binds phosphoinositides. It phosphorylates the activation loop of AGC kinases that are regulated by PI3K such as PKB, SGK, and PKC, among others, and is crucial for their activation. Thus, it contributes in regulating many processes including metabolism, growth, proliferation, and survival. PDK1 also has the ability to autophosphorylate and is constitutively active in mammalian cells. It is essential for normal embryo development and is important in regulating cell volume. The PDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270733 [Multi-domain]  Cd Length: 278  Bit Score: 163.92  E-value: 4.10e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05581   28 EYAIKVLDKRHIIKEKKVKYVTIEKEVLSRLAHPGIVKLYYTFQDESKLYFVLEYAPNGDLLEYIRKYGSLDEKCTRFYT 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIA------------------TIIKDGERATALAGTKPYMAP 142
Cdd:cd05581  108 AEIVLALEYLHSKGIIHRDLKPENILLDEDMHIKITDFGTAkvlgpdsspestkgdadsQIAYNQARAASFVGTAEYVSP 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 143 EIFhsfvnGGTGYSFEVDWWSVGVMAYELLRGWRPYdiHSSNAVEsLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEH 222
Cdd:cd05581  188 ELL-----NEKPAGKSSDLWALGCIIYQMLTGKPPF--RGSNEYL-TFQKIVKLEYEFPENFPPDAKDLIQKLLVLDPSK 259
                        250
                 ....*....|....*..
gi 247269852 223 RFSSlQDMQTAPSL-AH 238
Cdd:cd05581  260 RLGV-NENGGYDELkAH 275
STKc_SGK1 cd05602
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced ...
2-269 4.80e-48

Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK1 is ubiquitously expressed and is under transcriptional control of numerous stimuli including cell stress (cell shrinkage), serum, hormones (gluco- and mineralocorticoids), gonadotropins, growth factors, interleukin-6, and other cytokines. It plays roles in sodium retention and potassium elimination in the kidney, nutrient transport, salt sensitivity, memory consolidation, and cardiac repolarization. A common SGK1 variant is associated with increased blood pressure and body weight. SGK1 may also contribute to tumor growth, neurodegeneration, fibrosing disease, and ischemia. The SGK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270753 [Multi-domain]  Cd Length: 339  Bit Score: 165.58  E-value: 4.80e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEIL-QEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05602   35 YAVKVLQKKAILKKKEEKHIMSERNVLlKNVKHPFLVGLHFSFQTTDKLYFVLDYINGGELFYHLQRERCFLEPRARFYA 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIA--TIIKDGERATaLAGTKPYMAPEIFHSfvnggTGYSFE 158
Cdd:cd05602  115 AEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCkeNIEPNGTTST-FCGTPEYLAPEVLHK-----QPYDRT 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYdiHSSNAVESLVQLFSTvSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQTAPS--- 235
Cdd:cd05602  189 VDWWCLGAVLYEMLYGLPPF--YSRNTAEMYDNILNK-PLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFTEIKNhif 265
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 247269852 236 LAHVLWDDLSEKKVEPGFVPN----KGRLHCDPTFELE 269
Cdd:cd05602  266 FSPINWDDLINKKITPPFNPNvsgpNDLRHFDPEFTDE 303
STKc_PKN cd05589
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N; STKs catalyze the transfer ...
1-278 2.64e-47

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKN has a C-terminal catalytic domain that is highly homologous to PKCs. Its unique N-terminal regulatory region contains antiparallel coiled-coil (ACC) domains. In mammals, there are three PKN isoforms from different genes (designated PKN-alpha, beta, and gamma), which show different enzymatic properties, tissue distribution, and varied functions. PKN can be activated by the small GTPase Rho, and by fatty acids such as arachidonic and linoleic acids. It is involved in many biological processes including cytokeletal regulation, cell adhesion, vesicle transport, glucose transport, regulation of meiotic maturation and embryonic cell cycles, signaling to the nucleus, and tumorigenesis. The PKN subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270741 [Multi-domain]  Cd Length: 326  Bit Score: 163.24  E-value: 2.64e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRE---LEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVqFSEDTVR 77
Cdd:cd05589   26 LFAIKALKKGDIIARDEVESLMCEkriFETVNSARHPFLVNLFACFQTPEHVCFVMEYAAGGDLMMHIHEDV-FSEPRAV 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  78 LYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAtiiKDG----ERATALAGTKPYMAPEIFHSfvnggT 153
Cdd:cd05589  105 FYAACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLC---KEGmgfgDRTSTFCGTPEFLAPEVLTD-----T 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 154 GYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAV-ESLVqlfsTVSVQYvPTW-SKEMVALLRKLLTVNPEHRFSS----L 227
Cdd:cd05589  177 SYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVfDSIV----NDEVRY-PRFlSTEAISIMRRLLRKNPERRLGAserdA 251
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 247269852 228 QDMQTAPSLAHVLWDDLSEKKVEPGFVPN-KGRL---HCDPTFELEEMIL----ESRPL 278
Cdd:cd05589  252 EDVKKQPFFRNIDWEALLARKIKPPFVPTiKSPEdvsNFDEEFTSEKPVLtppkEPRPL 310
STKc_YPK1_like cd05585
Catalytic domain of Yeast Protein Kinase 1-like Serine/Threonine Kinases; STKs catalyze the ...
1-255 3.13e-47

Catalytic domain of Yeast Protein Kinase 1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of fungal proteins with similarity to the AGC STKs, Saccharomyces cerevisiae YPK1 and Schizosaccharomyces pombe Gad8p. YPK1 is required for cell growth and acts as a downstream kinase in the sphingolipid-mediated signaling pathway of yeast. It also plays a role in efficient endocytosis and in the maintenance of cell wall integrity. Gad8p is a downstream target of Tor1p, the fission yeast homolog of mTOR. It plays a role in cell growth and sexual development. The YPK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270737 [Multi-domain]  Cd Length: 313  Bit Score: 162.74  E-value: 3.13e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05585   21 IYALKTIRKAHIVSRSEVTHTLAERTVLAQVDCPFIVPLKFSFQSPEKLYLVLAFINGGELFHHLQREGRFDLSRARFYT 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHsfvngGTGYSFEV 159
Cdd:cd05585  101 AELLCALECLHKFNVIYRDLKPENILLDYTGHIALCDFGLCKLnMKDDDKTNTFCGTPEYLAPELLL-----GHGYTKAV 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 160 DWWSVGVMAYELLRGWRPYdiHSSNAVESLVQLFsTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSS--LQDMQTAPSLA 237
Cdd:cd05585  176 DWWTLGVLLYEMLTGLPPF--YDENTNEMYRKIL-QEPLRFPDGFDRDAKDLLIGLLNRDPTKRLGYngAQEIKNHPFFD 252
                        250
                 ....*....|....*...
gi 247269852 238 HVLWDDLSEKKVEPGFVP 255
Cdd:cd05585  253 QIDWKRLLMKKIQPPFKP 270
STKc_Sid2p_like cd05600
Catalytic domain of Fungal Sid2p-like Protein Serine/Threonine Kinases; STKs catalyze the ...
3-255 3.48e-47

Catalytic domain of Fungal Sid2p-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This group contains fungal kinases including Schizosaccharomyces pombe Sid2p and Saccharomyces cerevisiae Dbf2p. Group members show similarity to NDR kinases in that they contain an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Sid2p plays a crucial role in the septum initiation network (SIN) and in the initiation of cytokinesis. Dbf2p is important in regulating the mitotic exit network (MEN) and in cytokinesis. The Sid2p-like group is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270751 [Multi-domain]  Cd Length: 386  Bit Score: 164.82  E-value: 3.48e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICE 82
Cdd:cd05600   40 ALKIMKKKVLFKLNEVNHVLTERDILTTTNSPWLVKLLYAFQDPENVYLAMEYVPGGDFRTLLNNSGILSEEHARFYIAE 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAT--------------------------------------II 124
Cdd:cd05600  120 MFAAISSLHQLGYIHRDLKPENFLIDSSGHIKLTDFGLASgtlspkkiesmkirleevkntafleltakerrniyramRK 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 125 KDGERATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAV-------ESLVQLFSTVS 197
Cdd:cd05600  200 EDQNYANSVVGSPDYMAPEVLR-----GEGYDLTVDYWSLGCILFECLVGFPPFSGSTPNETwanlyhwKKTLQRPVYTD 274
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 198 VQYVPTWSKEMVALLRKLLTvNPEHRFSSLQDMQTAPSLAHVLWDDLSEkKVEPGFVP 255
Cdd:cd05600  275 PDLEFNLSDEAWDLITKLIT-DPQDRLQSPEQIKNHPFFKNIDWDRLRE-GSKPPFIP 330
STKc_beta_ARK cd05606
Catalytic domain of the Serine/Threonine Kinase, beta-adrenergic receptor kinase; STKs ...
1-255 8.10e-47

Catalytic domain of the Serine/Threonine Kinase, beta-adrenergic receptor kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The beta-ARK group is composed of GRK2, GRK3, and similar proteins. GRK2 and GRK3 are both widely expressed in many tissues, although GRK2 is present at higher levels. They contain an N-terminal RGS homology (RH) domain, a central catalytic domain, and C-terminal pleckstrin homology (PH) domain that mediates PIP2 and G protein betagamma-subunit translocation to the membrane. GRK2 (also called beta-ARK or beta-ARK1) is important in regulating several cardiac receptor responses. It plays a role in cardiac development and in hypertension. Deletion of GRK2 in mice results in embryonic lethality, caused by hypoplasia of the ventricular myocardium. GRK2 also plays important roles in the liver (as a regulator of portal blood pressure), in immune cells, and in the nervous system. Altered GRK2 expression has been reported in several disorders including major depression, schizophrenia, bipolar disorder, and Parkinsonism. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The beta-ARK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270757 [Multi-domain]  Cd Length: 279  Bit Score: 160.68  E-value: 8.10e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHV----FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTV 76
Cdd:cd05606   21 MYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGgdcpFIVCMTYAFQTPDKLCFILDLMNGGDLHYHLSQHGVFSEAEM 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  77 RLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDgERATALAGTKPYMAPEIFHSfvngGTGYS 156
Cdd:cd05606  101 RFYAAEVILGLEHMHNRFIVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVLQK----GVAYD 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 157 FEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRF----SSLQDMQT 232
Cdd:cd05606  176 SSADWFSLGCMLYKLLKGHSPFRQHKTKDKHEIDRMTLTMNVELPDSFSPELKSLLEGLLQRDVSKRLgclgRGATEVKE 255
                        250       260
                 ....*....|....*....|...
gi 247269852 233 APSLAHVLWDDLSEKKVEPGFVP 255
Cdd:cd05606  256 HPFFKGVDWQQVYLQKYPPPLIP 278
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
2-233 1.65e-46

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 165.19  E-value: 1.65e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:COG0515   35 VALKVLRPELAADPEARERFRREARALARLNHPNIVRVYDVGEEDGRPYLVMEYVEGESLADLLRRRGPLPPAEALRILA 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE--RATALAGTKPYMAPEIFHsfvngGTGYSFEV 159
Cdd:COG0515  115 QLAEALAAAHAAGIVHRDIKPANILLTPDGRVKLIDFGIARALGGATltQTGTVVGTPGYMAPEQAR-----GEPVDPRS 189
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 247269852 160 DWWSVGVMAYELLRGWRPYDIHSSNAV-ESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQTA 233
Cdd:COG0515  190 DVYSLGVTLYELLTGRPPFDGDSPAELlRAHLREPPPPPSELRPDLPPALDAIVLRALAKDPEERYQSAAELAAA 264
STKc_phototropin_like cd05574
Catalytic domain of Phototropin-like Serine/Threonine Kinases; STKs catalyze the transfer of ...
2-255 8.22e-46

Catalytic domain of Phototropin-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phototropins are blue-light receptors that control responses such as phototropism, stromatal opening, and chloroplast movement in order to optimize the photosynthetic efficiency of plants. They are light-activated STKs that contain an N-terminal photosensory domain and a C-terminal catalytic domain. The N-terminal domain contains two LOV (Light, Oxygen or Voltage) domains that binds FMN. Photoexcitation of the LOV domains results in autophosphorylation at multiple sites and activation of the catalytic domain. In addition to plant phototropins, included in this subfamily are predominantly uncharacterized fungal STKs whose catalytic domains resemble the phototropin kinase domain. One protein from Neurospora crassa is called nrc-2, which plays a role in growth and development by controlling entry into the conidiation program. The phototropin-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270726 [Multi-domain]  Cd Length: 316  Bit Score: 159.32  E-value: 8.22e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLrYHL---QQNVQFSEDTVRL 78
Cdd:cd05574   29 FAMKVLDKEEMIKRNKVKRVLTEREILATLDHPFLPTLYASFQTSTHLCFVMDYCPGGEL-FRLlqkQPGKRLPEEVARF 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAT--------IIKD----------------------GE 128
Cdd:cd05574  108 YAAEVLLALEYLHLLGFVYRDLKPENILLHESGHIMLTDFDLSKqssvtpppVRKSlrkgsrrssvksieketfvaepSA 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 129 RATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVeslvqlFSTVSVQYV-----PT 203
Cdd:cd05574  188 RSNSFVGTEEYIAPEVIK-----GDGHGSAVDWWTLGILLYEMLYGTTPFKGSNRDET------FSNILKKELtfpesPP 256
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 247269852 204 WSKEMVALLRKLLTVNPEHRFSSL---QDMQTAPSLAHVLWDDLseKKVEPGFVP 255
Cdd:cd05574  257 VSSEAKDLIRKLLVKDPSKRLGSKrgaSEIKRHPFFRGVNWALI--RNMTPPIIP 309
STKc_aPKC cd05588
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C; STKs catalyze the ...
1-269 2.77e-45

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. The aPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270740 [Multi-domain]  Cd Length: 328  Bit Score: 157.97  E-value: 2.77e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEIL-QEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLY 79
Cdd:cd05588   22 IYAMKVIKKELVNDDEDIDWVQTEKHVFeTASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRRLPEEHARFY 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHsfvngGTGYSFE 158
Cdd:cd05588  102 SAEISLALNFLHEKGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEgLRPGDTTSTFCGTPNYIAPEILR-----GEDYGFS 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDIHSS------NAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRF-----SSL 227
Cdd:cd05588  177 VDWWALGVLMFEMLAGRSPFDIVGSsdnpdqNTEDYLFQVILEKPIRIPRSLSVKAASVLKGFLNKNPAERLgchpqTGF 256
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 247269852 228 QDMQTAPSLAHVLWDDLSEKKVEPGFVPN----KGRLHCDPTFELE 269
Cdd:cd05588  257 ADIQSHPFFRTIDWEQLEQKQVTPPYKPRieseRDLENFDPQFTNE 302
STKc_nPKC_epsilon cd05591
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon; STKs catalyze ...
1-255 5.44e-45

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-epsilon has been shown to behave as an oncoprotein. Its overexpression contributes to neoplastic transformation depending on the cell type. It contributes to oncogenesis by inducing disordered cell growth and inhibiting cell death. It also plays a role in tumor invasion and metastasis. PKC-epsilon has also been found to confer cardioprotection against ischemia and reperfusion-mediated damage. Other cellular functions include the regulation of gene expression, cell adhesion, and cell motility. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-epsilon subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270743 [Multi-domain]  Cd Length: 321  Bit Score: 157.27  E-value: 5.44e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQ-EIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLY 79
Cdd:cd05591   22 VYAIKVLKKDVILQDDDVDCTMTEKRILAlAAKHPFLTALHSCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEPRARFY 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHSFvnggtGYSFE 158
Cdd:cd05591  102 AAEVTLALMFLHRHGVIYRDLKLDNILLDAEGHCKLADFGMCKEgILNGKTTTTFCGTPDYIAPEILQEL-----EYGPS 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDIHSSNaveslvQLFSTV---SVQYvPTW-SKEMVALLRKLLTVNPEHRFSSL--QDMQT 232
Cdd:cd05591  177 VDWWALGVLMYEMMAGQPPFEADNED------DLFESIlhdDVLY-PVWlSKEAVSILKAFMTKNPAKRLGCVasQGGED 249
                        250       260
                 ....*....|....*....|....*..
gi 247269852 233 A----PSLAHVLWDDLSEKKVEPGFVP 255
Cdd:cd05591  250 AirqhPFFREIDWEALEQRKVKPPFKP 276
STKc_PRKX_like cd05612
Catalytic domain of PRKX-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of ...
2-255 9.36e-45

Catalytic domain of PRKX-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include human PRKX (X chromosome-encoded protein kinase), Drosophila DC2, and similar proteins. PRKX is present in many tissues including fetal and adult brain, kidney, and lung. The PRKX gene is located in the Xp22.3 subregion and has a homolog called PRKY on the Y chromosome. An abnormal interchange between PRKX aand PRKY leads to the sex reversal disorder of XX males and XY females. PRKX is implicated in granulocyte/macrophage lineage differentiation, renal cell epithelial migration, and tubular morphogenesis in the developing kidney. The PRKX-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270763 [Multi-domain]  Cd Length: 292  Bit Score: 155.67  E-value: 9.36e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd05612   29 YALKVMAIPEVIRLKQEQHVHNEKRVLKEVSHPFIIRLFWTEHDQRFLYMLMEYVPGGELFSYLRNSGRFSNSTGLFYAS 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDgeRATALAGTKPYMAPEIFHSfvnggTGYSFEVDW 161
Cdd:cd05612  109 EIVCALEYLHSKEIVYRDLKPENILLDKEGHIKLTDFGFAKKLRD--RTWTLCGTPEYLAPEVIQS-----KGHNKAVDW 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 162 WSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEmvaLLRKLLTVNPEHRFSSL----QDMQTAPSLA 237
Cdd:cd05612  182 WALGILIYEMLVGYPPFFDDNPFGIYEKILAGKLEFPRHLDLYAKD---LIKKLLVVDRTRRLGNMkngaDDVKNHRWFK 258
                        250
                 ....*....|....*...
gi 247269852 238 HVLWDDLSEKKVEPGFVP 255
Cdd:cd05612  259 SVDWDDVPQRKLKPPIVP 276
STKc_PKB_alpha cd05594
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1); ...
2-255 2.08e-44

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-alpha is predominantly expressed in endothelial cells. It is critical for the regulation of angiogenesis and the maintenance of vascular integrity. It also plays a role in adipocyte differentiation. Mice deficient in PKB-alpha exhibit perinatal morbidity, growth retardation, reduction in body weight accompanied by reduced sizes of multiple organs, and enhanced apoptosis in some cell types. PKB-alpha activity has been reported to be frequently elevated in breast and prostate cancers. In some cancer cells, PKB-alpha may act as a suppressor of metastasis. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. The PKB-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270746 [Multi-domain]  Cd Length: 356  Bit Score: 156.73  E-value: 2.08e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd05594   53 YAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGA 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQ-HIIHRDVKPDNILLDEQGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEV 159
Cdd:cd05594  133 EIVSALDYLHSEkNVVYRDLKLENLMLDKDGHIKITDFGLCKEgIKDGATMKTFCGTPEYLAPEVLED-----NDYGRAV 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 160 DWWSVGVMAYELLRGWRPYdihSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRF----SSLQDMQTAPS 235
Cdd:cd05594  208 DWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILMEEIRFPRTLSPEAKSLLSGLLKKDPKQRLgggpDDAKEIMQHKF 284
                        250       260
                 ....*....|....*....|
gi 247269852 236 LAHVLWDDLSEKKVEPGFVP 255
Cdd:cd05594  285 FAGIVWQDVYEKKLVPPFKP 304
STKc_aPKC_iota cd05618
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota; STKs catalyze ...
1-256 2.97e-44

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. The aPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270769 [Multi-domain]  Cd Length: 364  Bit Score: 156.35  E-value: 2.97e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIE-HVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLY 79
Cdd:cd05618   47 IYAMKVVKKELVNDDEDIDWVQTEKHVFEQASnHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFY 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHsfvngGTGYSFE 158
Cdd:cd05618  127 SAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEgLRPGDTTSTFCGTPNYIAPEILR-----GEDYGFS 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDIHSS------NAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRF-----SSL 227
Cdd:cd05618  202 VDWWALGVLMFEMMAGRSPFDIVGSsdnpdqNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLgchpqTGF 281
                        250       260
                 ....*....|....*....|....*....
gi 247269852 228 QDMQTAPSLAHVLWDDLSEKKVEPGFVPN 256
Cdd:cd05618  282 ADIQGHPFFRNVDWDLMEQKQVVPPFKPN 310
STKc_NDR_like_fungal cd05629
Catalytic domain of Fungal Nuclear Dbf2-Related kinase-like Serine/Threonine Kinases; STKs ...
1-256 6.22e-44

Catalytic domain of Fungal Nuclear Dbf2-Related kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This group is composed of fungal NDR-like proteins including Saccharomyces cerevisiae CBK1 (or CBK1p), Schizosaccharomyces pombe Orb6 (or Orb6p), Ustilago maydis Ukc1 (or Ukc1p), and Neurospora crassa Cot1. Like NDR kinase, group members contain an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. CBK1 is an essential component in the RAM (regulation of Ace2p activity and cellular morphogenesis) network. CBK1 and Orb6 play similar roles in coordinating cell morphology with cell cycle progression. Ukc1 is involved in morphogenesis, pathogenicity, and pigment formation. Cot1 plays a role in polar tip extension.The fungal NDR subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270778 [Multi-domain]  Cd Length: 377  Bit Score: 155.78  E-value: 6.22e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05629   28 IYAMKTLLKSEMFKKDQLAHVKAERDVLAESDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIKYDTFSEDVTRFYM 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDF---------------------NIATIIKDGERATAL------ 133
Cdd:cd05629  108 AECVLAIEAVHKLGFIHRDIKPDNILIDRGGHIKLSDFglstgfhkqhdsayyqkllqgKSNKNRIDNRNSVAVdsinlt 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 134 ---------------------AGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLRGWRPYdiHSSNAVESLVQL 192
Cdd:cd05629  188 msskdqiatwkknrrlmaystVGTPDYIAPEIFL-----QQGYGQECDWWSLGAIMFECLIGWPPF--CSENSHETYRKI 260
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 247269852 193 FSTVSVQYVP---TWSKEMVALLRKLLTvNPEHRFS--SLQDMQTAPSLAHVLWDDLSEkkVEPGFVPN 256
Cdd:cd05629  261 INWRETLYFPddiHLSVEAEDLIRRLIT-NAENRLGrgGAHEIKSHPFFRGVDWDTIRQ--IRAPFIPQ 326
STKc_CRIK cd05601
Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase; STKs catalyze ...
2-255 7.81e-44

Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CRIK (also called citron kinase) is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger, and a pleckstrin homology (PH) domain, in addition to other motifs. The CRIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270752 [Multi-domain]  Cd Length: 328  Bit Score: 154.39  E-value: 7.81e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDL-----RYhlqqNVQFSEDTV 76
Cdd:cd05601   29 YAMKVLKKSETLAQEEVSFFEEERDIMAKANSPWITKLQYAFQDSENLYLVMEYHPGGDLlsllsRY----DDIFEESMA 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  77 RLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATAL--AGTKPYMAPEIFHSFVNGGTG 154
Cdd:cd05601  105 RFYLAELVLAIHSLHSMGYVHRDIKPENILIDRTGHIKLADFGSAAKLSSDKTVTSKmpVGTPDYIAPEVLTSMNGGSKG 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 155 -YSFEVDWWSVGVMAYELLRGWRPY-DIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTvNPEHRFsSLQDMQT 232
Cdd:cd05601  185 tYGVECDWWSLGIVAYEMLYGKTPFtEDTVIKTYSNIMNFKKFLKFPEDPKVSESAVDLIKGLLT-DAKERL-GYEGLCC 262
                        250       260
                 ....*....|....*....|...
gi 247269852 233 APSLAHVLWDDLSEKKvePGFVP 255
Cdd:cd05601  263 HPFFSGIDWNNLRQTV--PPFVP 283
STKc_DMPK_like cd05597
Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases; ...
2-255 1.12e-43

Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The DMPK-like subfamily is composed of DMPK and DMPK-related cell division control protein 42 (Cdc42) binding kinase (MRCK). DMPK is expressed in skeletal and cardiac muscles, and in central nervous tissues. The functional role of DMPK is not fully understood. It may play a role in the signal transduction and homeostasis of calcium. The DMPK gene is implicated in myotonic dystrophy 1 (DM1), an inherited multisystemic disorder with symptoms that include muscle hyperexcitability, progressive muscle weakness and wasting, cataract development, testicular atrophy, and cardiac conduction defects. The genetic basis for DM1 is the mutational expansion of a CTG repeat in the 3'-UTR of DMPK. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. Three isoforms of MRCK are known, named alpha, beta and gamma. MRCKgamma is expressed in heart and skeletal muscles, unlike MRCKalpha and MRCKbeta, which are expressed ubiquitously. The DMPK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270748 [Multi-domain]  Cd Length: 331  Bit Score: 154.04  E-value: 1.12e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ-NVQFSEDTVRLYI 80
Cdd:cd05597   29 YAMKILNKWEMLKRAETACFREERDVLVNGDRRWITKLHYAFQDENYLYLVMDYYCGGDLLTLLSKfEDRLPEEMARFYL 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDF-NIATIIKDGERATALA-GTKPYMAPEIFHSFVNGGTGYSFE 158
Cdd:cd05597  109 AEMVLAIDSIHQLGYVHRDIKPDNVLLDRNGHIRLADFgSCLKLREDGTVQSSVAvGTPDYISPEILQAMEDGKGRYGPE 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYdihssnAVESLVQLFSTVSVQ--------YVPTWSKEMVALLRKLLTVnPEHRF--SSLQ 228
Cdd:cd05597  189 CDWWSLGVCMYEMLYGETPF------YAESLVETYGKIMNHkehfsfpdDEDDVSEEAKDLIRRLICS-RERRLgqNGID 261
                        250       260
                 ....*....|....*....|....*..
gi 247269852 229 DMQTAPSLAHVLWDDLseKKVEPGFVP 255
Cdd:cd05597  262 DFKKHPFFEGIDWDNI--RDSTPPYIP 286
STKc_Chk2 cd14084
Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2; STKs catalyze ...
3-233 1.49e-43

Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Checkpoint Kinase 2 (Chk2) plays an important role in cellular responses to DNA double-strand breaks and related lesions. It is phosphorylated and activated by ATM kinase, resulting in its dissociation from sites of damage to phosphorylate downstream targets such as BRCA1, p53, cell cycle transcription factor E2F1, the promyelocytic leukemia protein (PML) involved in apoptosis, and CDC25 phosphatases, among others. Mutations in Chk2 is linked to a variety of cancers including familial breast cancer, myelodysplastic syndromes, prostate cancer, lung cancer, and osteosarcomas. Chk2 contains an N-terminal SQ/TQ cluster domain (SCD), a central forkhead-associated (FHA) domain, and a C-terminal catalytic kinase domain. The Chk2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270986 [Multi-domain]  Cd Length: 275  Bit Score: 152.16  E-value: 1.49e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQ-----QCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVR 77
Cdd:cd14084   35 AIKIINKRkftigSRREINKPRNIETEIEILKKLSHPCIIKIEDFFDAEDDYYIVLELMEGGELFDRVVSNKRLKEAICK 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  78 LYICEMALALDYLRSQHIIHRDVKPDNILL---DEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSFvnGGTG 154
Cdd:cd14084  115 LYFYQMLLAVKYLHSNGIIHRDLKPENVLLssqEEECLIKITDFGLSKILGETSLMKTLCGTPTYLAPEVLRSF--GTEG 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 155 YSFEVDWWSVGVMAYELLRGWRPYDIHSSNavESLVQLFSTVSVQYVPTW----SKEMVALLRKLLTVNPEHRFSSLQDM 230
Cdd:cd14084  193 YTRAVDCWSLGVILFICLSGYPPFSEEYTQ--MSLKEQILSGKYTFIPKAwknvSEEAKDLVKKMLVVDPSRRPSIEEAL 270

                 ...
gi 247269852 231 QTA 233
Cdd:cd14084  271 EHP 273
STKc_MRCK_beta cd05624
Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control ...
1-275 1.58e-43

Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MRCK-beta is expressed ubiquitously in many tissues. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. The MRCK-beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This alignment model includes the dimerization domain.


Pssm-ID: 270774 [Multi-domain]  Cd Length: 409  Bit Score: 155.55  E-value: 1.58e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ-NVQFSEDTVRLY 79
Cdd:cd05624   99 IYAMKILNKWEMLKRAETACFREERNVLVNGDCQWITTLHYAFQDENYLYLVMDYYVGGDLLTLLSKfEDKLPEDMARFY 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDF-NIATIIKDGERATALA-GTKPYMAPEIFHSFVNGGTGYSF 157
Cdd:cd05624  179 IGEMVLAIHSIHQLHYVHRDIKPDNVLLDMNGHIRLADFgSCLKMNDDGTVQSSVAvGTPDYISPEILQAMEDGMGKYGP 258
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 158 EVDWWSVGVMAYELLRGWRPYdihssnAVESLVQLFSTVS--------VQYVPTWSKEMVALLRKLLtVNPEHRF--SSL 227
Cdd:cd05624  259 ECDWWSLGVCMYEMLYGETPF------YAESLVETYGKIMnheerfqfPSHVTDVSEEAKDLIQRLI-CSRERRLgqNGI 331
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 247269852 228 QDMQTAPSLAHVLWDDLseKKVEPGFVPNKGRLHCDPTFELEEMILES 275
Cdd:cd05624  332 EDFKKHAFFEGLNWENI--RNLEAPYIPDVSSPSDTSNFDVDDDVLRN 377
STKc_GRK4 cd05631
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4; STKs ...
1-256 1.99e-43

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK4 has a limited tissue distribution. It is mainly found in the testis, but is also present in the cerebellum and kidney. It is expressed as multiple splice variants with different domain architectures and is post-translationally palmitoylated and localized in the membrane. GRK4 polymorphisms are associated with hypertension and salt sensitivity, as they cause hyperphosphorylation, desensitization, and internalization of the dopamine 1 (D1) receptor while increasing the expression of the angiotensin II type 1 receptor. GRK4 plays a crucial role in the D1 receptor regulation of sodium excretion and blood pressure. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173720 [Multi-domain]  Cd Length: 285  Bit Score: 152.07  E-value: 1.99e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ--NVQFSEDTVRL 78
Cdd:cd05631   27 MYACKKLEKKRIKKRKGEAMALNEKRILEKVNSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNmgNPGFDEQRAIF 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFE 158
Cdd:cd05631  107 YAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLAVQIPEGETVRGRVGTVGYMAPEVINN-----EKYTFS 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDIHSSNAV-ESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRF----SSLQDMQTA 233
Cdd:cd05631  182 PDWWGLGCLIYEMIQGQSPFRKRKERVKrEEVDRRVKEDQEEYSEKFSEDAKSICRMLLTKNPKERLgcrgNGAAGVKQH 261
                        250       260
                 ....*....|....*....|...
gi 247269852 234 PSLAHVLWDDLSEKKVEPGFVPN 256
Cdd:cd05631  262 PIFKNINFKRLEANMLEPPFCPD 284
STKc_nPKC_theta cd05619
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta; STKs catalyze ...
2-255 2.40e-43

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. Although T-cells also express other PKC isoforms, PKC-theta is unique in that upon antigen stimulation, it is translocated to the plasma membrane at the immunological synapse, where it mediates signals essential for T-cell activation. It is essential for TCR-induced proliferation, cytokine production, T-cell survival, and the differentiation and effector function of T-helper (Th) cells, particularly Th2 and Th17. PKC-theta is being developed as a therapeutic target for Th2-mediated allergic inflammation and Th17-mediated autoimmune diseases. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270770 [Multi-domain]  Cd Length: 331  Bit Score: 153.16  E-value: 2.40e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQ-EIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05619   33 FAIKALKKDVVLMDDDVECTMVEKRVLSlAWEHPFLTHLFCTFQTKENLFFVMEYLNGGDLMFHIQSCHKFDLPRATFYA 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIA--TIIKDGERATaLAGTKPYMAPEIFHsfvngGTGYSFE 158
Cdd:cd05619  113 AEIICGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCkeNMLGDAKTST-FCGTPDYIAPEILL-----GQKYNTS 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDIHSSnavESLVQLFSTVSVQYvPTW-SKEMVALLRKLLTVNPEHRFSSLQDMQTAPSLA 237
Cdd:cd05619  187 VDWWSFGVLLYEMLIGQSPFHGQDE---EELFQSIRMDNPFY-PRWlEKEAKDILVKLFVREPERRLGVRGDIRQHPFFR 262
                        250
                 ....*....|....*...
gi 247269852 238 HVLWDDLSEKKVEPGFVP 255
Cdd:cd05619  263 EINWEALEEREIEPPFKP 280
STKc_PKB_gamma cd05593
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3); ...
2-255 2.69e-43

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-gamma is predominantly expressed in neuronal tissues. Mice deficient in PKB-gamma show a reduction in brain weight due to the decreases in cell size and cell number. PKB-gamma has also been shown to be upregulated in estrogen-deficient breast cancer cells, androgen-independent prostate cancer cells, and primary ovarian tumors. It acts as a key mediator in the genesis of ovarian cancer. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. The PKB-gamma subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270745 [Multi-domain]  Cd Length: 348  Bit Score: 153.70  E-value: 2.69e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd05593   43 YAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGA 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEVD 160
Cdd:cd05593  123 EIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEgITDAATMKTFCGTPEYLAPEVLED-----NDYGRAVD 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 161 WWSVGVMAYELLRGWRPYdihSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRF----SSLQDMQTAPSL 236
Cdd:cd05593  198 WWGLGVVMYEMMCGRLPF---YNQDHEKLFELILMEDIKFPRTLSADAKSLLSGLLIKDPNKRLgggpDDAKEIMRHSFF 274
                        250
                 ....*....|....*....
gi 247269852 237 AHVLWDDLSEKKVEPGFVP 255
Cdd:cd05593  275 TGVNWQDVYDKKLVPPFKP 293
STKc_Rim15_like cd05611
Catalytic domain of fungal Rim15-like Protein Serine/Threonine Kinases; STKs catalyze the ...
2-242 2.85e-43

Catalytic domain of fungal Rim15-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include Saccharomyces cerevisiae Rim15, Schizosaccharomyces pombe cek1, and similar fungal proteins. They contain a central catalytic domain, which contains an insert relative to MAST kinases. In addition, Rim15 contains a C-terminal signal receiver (REC) domain while cek1 contains an N-terminal PAS domain. Rim15 (or Rim15p) functions as a regulator of meiosis. It acts as a downstream effector of PKA and regulates entry into stationary phase (G0). Thus, it plays a crucial role in regulating yeast proliferation, differentiation, and aging. Cek1 may facilitate progression of mitotic anaphase. The Rim15-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270762 [Multi-domain]  Cd Length: 263  Bit Score: 151.09  E-value: 2.85e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQ-EIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05611   24 FAIKVLKKSDMIAKNQVTNVKAERAIMMiQGESPYVAKLYYSFQSKDYLYLVMEYLNGGDCASLIKTLGGLPEDWAKQYI 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFEVD 160
Cdd:cd05611  104 AEVVLGVEDLHQRGIIHRDIKPENLLIDQTGHLKLTDFGLSRNGLEKRHNKKFVGTPDYLAPETIL-----GVGDDKMSD 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 161 WWSVGVMAYELLRGWRPYDIHSSNAVeslvqlFSTVsVQYVPTW--------SKEMVALLRKLLTVNPEHRFSS--LQDM 230
Cdd:cd05611  179 WWSLGCVIFEFLFGYPPFHAETPDAV------FDNI-LSRRINWpeevkefcSPEAVDLINRLLCMDPAKRLGAngYQEI 251
                        250
                 ....*....|..
gi 247269852 231 QTAPSLAHVLWD 242
Cdd:cd05611  252 KSHPFFKSINWD 263
STKc_nPKC_delta cd05620
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta; STKs catalyze ...
2-255 7.65e-43

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. It slows down cell proliferation, inducing cell cycle arrest and enhancing cell differentiation. PKC-delta is also involved in the regulation of transcription as well as immune and inflammatory responses. It plays a central role in the genotoxic stress response that leads to DNA damaged-induced apoptosis. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-delta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173710 [Multi-domain]  Cd Length: 316  Bit Score: 151.25  E-value: 7.65e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQ-EIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05620   23 FAVKALKKDVVLIDDDVECTMVEKRVLAlAWENPFLTHLYCTFQTKEHLFFVMEFLNGGDLMFHIQDKGRFDLYRATFYA 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE-RATALAGTKPYMAPEIFHsfvngGTGYSFEV 159
Cdd:cd05620  103 AEIVCGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENVFGDnRASTFCGTPDYIAPEILQ-----GLKYTFSV 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 160 DWWSVGVMAYELLRGWRPYdiHSSNAVEslvqLFSTVSVQ--YVPTW-SKEMVALLRKLLTVNPEHRFSSLQDMQTAPSL 236
Cdd:cd05620  178 DWWSFGVLLYEMLIGQSPF--HGDDEDE----LFESIRVDtpHYPRWiTKESKDILEKLFERDPTRRLGVVGNIRGHPFF 251
                        250
                 ....*....|....*....
gi 247269852 237 AHVLWDDLSEKKVEPGFVP 255
Cdd:cd05620  252 KTINWTALEKRELDPPFKP 270
PKc cd00180
Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group ...
2-225 1.04e-42

Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. PKs make up a large family of serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and more than 500 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase.


Pssm-ID: 270622 [Multi-domain]  Cd Length: 215  Bit Score: 147.80  E-value: 1.04e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIErdEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLR-YHLQQNVQFSEDTVRLYI 80
Cdd:cd00180   21 VAVKVIPKEKLKK--LLEELLREIEILKKLNHPNIVKLYDVFETENFLYLVMEYCEGGSLKdLLKENKGPLSEEEALSIL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKP---YMAPEIFhsfvnGGTGYSF 157
Cdd:cd00180   99 RQLLSALEYLHSNGIIHRDLKPENILLDSDGTVKLADFGLAKDLDSDDSLLKTTGGTTppyYAPPELL-----GGRYYGP 173
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 158 EVDWWSVGVMAYELlrgwrpydihssnaveslvqlfstvsvqyvptwsKEMVALLRKLLTVNPEHRFS 225
Cdd:cd00180  174 KVDIWSLGVILYEL----------------------------------EELKDLIRRMLQYDPKKRPS 207
STKc_ROCK cd05596
Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein ...
2-255 1.22e-42

Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ROCK is also referred to as Rho-associated kinase or simply as Rho kinase. It contains an N-terminal extension, a catalytic kinase domain, and a long C-terminal extension, which contains a coiled-coil region encompassing a Rho-binding domain (RBD) and a pleckstrin homology (PH) domain. ROCK is auto-inhibited by the RBD and PH domain interacting with the catalytic domain. It is activated via interaction with Rho GTPases and is involved in many cellular functions including contraction, adhesion, migration, motility, proliferation, and apoptosis. The ROCK subfamily consists of two isoforms, ROCK1 and ROCK2, which may be functionally redundant in some systems, but exhibit different tissue distributions. Both isoforms are ubiquitously expressed in most tissues, but ROCK2 is more prominent in brain and skeletal muscle while ROCK1 is more pronounced in the liver, testes, and kidney. Studies in knockout mice result in different phenotypes, suggesting that the two isoforms do not compensate for each other during embryonic development. The ROCK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270747 [Multi-domain]  Cd Length: 352  Bit Score: 151.76  E-value: 1.22e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLrYHLQQNVQFSEDTVRLYIC 81
Cdd:cd05596   54 YAMKLLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDKYLYMVMDYMPGGDL-VNLMSNYDVPEKWARFYTA 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFniATIIKDGE----RATALAGTKPYMAPEIFHSfvNGGTG-YS 156
Cdd:cd05596  133 EVVLALDAIHSMGFVHRDVKPDNMLLDASGHLKLADF--GTCMKMDKdglvRSDTAVGTPDYISPEVLKS--QGGDGvYG 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 157 FEVDWWSVGVMAYELLRGWRPYdihssnAVESLVQLFSTV-----SVQY--VPTWSKEMVALLRKLLTvNPEHRF--SSL 227
Cdd:cd05596  209 RECDWWSVGVFLYEMLVGDTPF------YADSLVGTYGKImnhknSLQFpdDVEISKDAKSLICAFLT-DREVRLgrNGI 281
                        250       260
                 ....*....|....*....|....*...
gi 247269852 228 QDMQTAPSLAHVLWDDLSEKKVEPGFVP 255
Cdd:cd05596  282 EEIKAHPFFKNDQWTWDNIRETVPPVVP 309
PKc_STE cd05122
Catalytic domain of STE family Protein Kinases; PKs catalyze the transfer of the ...
1-231 1.51e-42

Catalytic domain of STE family Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. This family is composed of STKs, and some dual-specificity PKs that phosphorylate both threonine and tyrosine residues of target proteins. Most members are kinases involved in mitogen-activated protein kinase (MAPK) signaling cascades, acting as MAPK kinases (MAPKKs), MAPKK kinases (MAPKKKs), or MAPKKK kinases (MAP4Ks). The MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The pathways involve a triple kinase core cascade comprising of the MAPK, which is phosphorylated and activated by a MAPKK, which itself is phosphorylated and activated by a MAPKKK. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAPKKK to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Other STE family members include p21-activated kinases (PAKs) and class III myosins, among others. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain, which can phosphorylate several cytoskeletal proteins, conventional myosin regulatory light chains, as well as autophosphorylate the C-terminal motor domain. They play an important role in maintaining the structural integrity of photoreceptor cell microvilli. The STE family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270692 [Multi-domain]  Cd Length: 254  Bit Score: 148.89  E-value: 1.51e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNvfrELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQ-FSEDTVRLY 79
Cdd:cd05122   27 IVAIKKINLESKEKKESILN---EIAILKKCKHPNIVKYYGSYLKKDELWIVMEFCSGGSLKDLLKNTNKtLTEQQIAYV 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIfhsfVNGGTgYSFEV 159
Cdd:cd05122  104 CKEVLKGLEYLHSHGIIHRDIKAANILLTSDGEVKLIDFGLSAQLSDGKTRNTFVGTPYWMAPEV----IQGKP-YGFKA 178
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 160 DWWSVGVMAYELLRGWRPY-DIHSSNAveslvqLFSTVSVQYV-----PTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd05122  179 DIWSLGITAIEMAEGKPPYsELPPMKA------LFLIATNGPPglrnpKKWSKEFKDFLKKCLQKDPEKRPTAEQLLK 250
STKc_cPKC cd05587
Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C; ...
1-255 9.44e-42

Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. cPKCs are potent kinases for histones, myelin basic protein, and protamine. They depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. cPKCs contain a calcium-binding C2 region in their regulatory domain. There are four cPKC isoforms, named alpha, betaI, betaII, and gamma. PKC-gamma is mainly expressed in neuronal tissues. It plays a role in protection from ischemia. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. The cPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270739 [Multi-domain]  Cd Length: 320  Bit Score: 148.69  E-value: 9.44e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEH-VFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLY 79
Cdd:cd05587   23 LYAIKILKKDVIIQDDDVECTMVEKRVLALSGKpPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEPVAVFY 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHSfvnggTGYSFE 158
Cdd:cd05587  103 AAEIAVGLFFLHSKGIIYRDLKLDNVMLDAEGHIKIADFGMCKEgIFGGKTTRTFCGTPDYIAPEIIAY-----QPYGKS 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDihssnaVESLVQLFSTV---SVQYVPTWSKEMVALLRKLLTVNPEHRF----SSLQDMQ 231
Cdd:cd05587  178 VDWWAYGVLLYEMLAGQPPFD------GEDEDELFQSImehNVSYPKSLSKEAVSICKGLLTKHPAKRLgcgpTGERDIK 251
                        250       260
                 ....*....|....*....|....
gi 247269852 232 TAPSLAHVLWDDLSEKKVEPGFVP 255
Cdd:cd05587  252 EHPFFRRIDWEKLERREIQPPFKP 275
STKc_cPKC_beta cd05616
Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta; STKs ...
1-259 1.02e-41

Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PKC beta isoforms (I and II), generated by alternative splicing of a single gene, are preferentially activated by hyperglycemia-induced DAG (1,2-diacylglycerol) in retinal tissues. This is implicated in diabetic microangiopathy such as ischemia, neovascularization, and abnormal vasodilator function. PKC-beta also plays an important role in VEGF signaling. In addition, glucose regulates proliferation in retinal endothelial cells via PKC-betaI. PKC-beta is also being explored as a therapeutic target in cancer. It contributes to tumor formation and is involved in the tumor host mechanisms of inflammation and angiogenesis. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, cPKCs depend on calcium, DAG, and in most cases, phosphatidylserine (PS) for activation. The cPKC-beta subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270767 [Multi-domain]  Cd Length: 323  Bit Score: 148.61  E-value: 1.02e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQ-EIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLY 79
Cdd:cd05616   27 LYAVKILKKDVVIQDDDVECTMVEKRVLAlSGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFY 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHSfvnggTGYSFE 158
Cdd:cd05616  107 AAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEnIWDGVTTKTFCGTPDYIAPEIIAY-----QPYGKS 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDIHSSNaveslvQLFSTV---SVQYVPTWSKEMVALLRKLLTVNPEHRF----SSLQDMQ 231
Cdd:cd05616  182 VDWWAFGVLLYEMLAGQAPFEGEDED------ELFQSImehNVAYPKSMSKEAVAICKGLMTKHPGKRLgcgpEGERDIK 255
                        250       260
                 ....*....|....*....|....*....
gi 247269852 232 TAPSLAHVLWDDLSEKKVEPGFVPN-KGR 259
Cdd:cd05616  256 EHAFFRYIDWEKLERKEIQPPYKPKaCGR 284
STKc_MRCK_alpha cd05623
Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 ...
1-255 1.80e-41

Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MRCK-alpha is expressed ubiquitously in many tissues. It plays a role in the regulation of peripheral actin reorganization and neurite outgrowth. It may also play a role in the transferrin iron uptake pathway. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. The MRCK-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This alignment model includes the dimerization domain.


Pssm-ID: 270773 [Multi-domain]  Cd Length: 409  Bit Score: 150.17  E-value: 1.80e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ-NVQFSEDTVRLY 79
Cdd:cd05623   99 VFAMKILNKWEMLKRAETACFREERDVLVNGDSQWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKfEDRLPEDMARFY 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDF-NIATIIKDGERATALA-GTKPYMAPEIFHSFVNGGTGYSF 157
Cdd:cd05623  179 LAEMVLAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFgSCLKLMEDGTVQSSVAvGTPDYISPEILQAMEDGKGKYGP 258
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 158 EVDWWSVGVMAYELLRGWRPYdihssnAVESLVQLFSTV-----SVQY---VPTWSKEMVALLRKLLtVNPEHRF--SSL 227
Cdd:cd05623  259 ECDWWSLGVCMYEMLYGETPF------YAESLVETYGKImnhkeRFQFptqVTDVSENAKDLIRRLI-CSREHRLgqNGI 331
                        250       260
                 ....*....|....*....|....*...
gi 247269852 228 QDMQTAPSLAHVLWDDLseKKVEPGFVP 255
Cdd:cd05623  332 EDFKNHPFFVGIDWDNI--RNCEAPYIP 357
STKc_GRK3 cd05633
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3; STKs ...
1-268 4.09e-41

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK3, also called beta-adrenergic receptor kinase 2 (beta-ARK2), is widely expressed in many tissues. It is involved in modulating the cholinergic response of airway smooth muscles, and also plays a role in dopamine receptor regulation. GRK3-deficient mice show a lack of olfactory receptor desensitization and altered regulation of the M2 muscarinic airway. GRK3 promoter polymorphisms may also be associated with bipolar disorder. GRK3 contains an N-terminal RGS homology (RH) domain, a central catalytic domain, and C-terminal pleckstrin homology (PH) domain that mediates PIP2 and G protein betagamma-subunit translocation to the membrane. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270781 [Multi-domain]  Cd Length: 346  Bit Score: 147.52  E-value: 4.09e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRE---LEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVR 77
Cdd:cd05633   32 MYAMKCLDKKRIKMKQGETLALNErimLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMR 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  78 LYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDgERATALAGTKPYMAPEIFHSfvngGTGYSF 157
Cdd:cd05633  112 FYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVLQK----GTAYDS 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 158 EVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRF----SSLQDMQTA 233
Cdd:cd05633  187 SADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDSFSPELKSLLEGLLQRDVSKRLgchgRGAQEVKEH 266
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 247269852 234 PSLAHVLWDDLSEKKVEPGFVPNKGRLHCDPTFEL 268
Cdd:cd05633  267 SFFKGIDWQQVYLQKYPPPLIPPRGEVNAADAFDI 301
STKc_DCKL cd14095
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called ...
1-231 6.27e-41

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called Doublecortin-like and CAM kinase-like); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL (or DCAMKL) proteins belong to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL proteins contain a C-terminal kinase domain with similarity to CAMKs. They are involved in the regulation of cAMP signaling. Vertebrates contain three DCKL proteins (DCKL1-3); DCKL1 and 2 also contain a serine, threonine, and proline rich domain (SP), while DCKL3 contains only a single DCX domain instead of tandem domains. The DCKL subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270997 [Multi-domain]  Cd Length: 258  Bit Score: 144.78  E-value: 6.27e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVrnVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14095   27 EYALKIIDKAKCKGKEHM--IENEVAILRRVKHPNIVQLIEEYDTDTELYLVMELVKGGDLFDAITSSTKFTERDASRMV 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQG----HAHLTDFNIATIIKdgERATALAGTKPYMAPEIFhsfvnGGTGYS 156
Cdd:cd14095  105 TDLAQALKYLHSLSIVHRDIKPENLLVVEHEdgskSLKLADFGLATEVK--EPLFTVCGTPTYVAPEIL-----AETGYG 177
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 247269852 157 FEVDWWSVGVMAYELLRGWRPYDiHSSNAVESLVQLFSTVSVQYV-PTW---SKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd14095  178 LKVDIWAAGVITYILLCGFPPFR-SPDRDQEELFDLILAGEFEFLsPYWdniSDSAKDLISRMLVVDPEKRYSAGQVLD 255
STKc_GRK6 cd05630
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6; STKs ...
1-256 1.13e-40

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK6 is widely expressed in many tissues and is expressed as multiple splice variants with different domain architectures. It is post-translationally palmitoylated and localized in the membrane. GRK6 plays important roles in the regulation of dopamine, M3 muscarinic, opioid, and chemokine receptor signaling. It also plays maladaptive roles in addiction and Parkinson's disease. GRK6-deficient mice exhibit altered dopamine receptor regulation, decreased lymphocyte chemotaxis, and increased acute inflammation and neutrophil chemotaxis. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270779 [Multi-domain]  Cd Length: 285  Bit Score: 144.78  E-value: 1.13e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ--NVQFSEDTVRL 78
Cdd:cd05630   27 MYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHmgQAGFPEARAVF 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFE 158
Cdd:cd05630  107 YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN-----ERYTFS 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDIHSSN-AVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRF----SSLQDMQTA 233
Cdd:cd05630  182 PDWWALGCLLYEMIAGQSPFQQRKKKiKREEVERLVKEVPEEYSEKFSPQARSLCSMLLCKDPAERLgcrgGGAREVKEH 261
                        250       260
                 ....*....|....*....|...
gi 247269852 234 PSLAHVLWDDLSEKKVEPGFVPN 256
Cdd:cd05630  262 PLFKKLNFKRLGAGMLEPPFKPD 284
STKc_aPKC_zeta cd05617
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta; STKs catalyze ...
1-255 1.14e-40

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-zeta plays a critical role in activating the glucose transport response. It is activated by glucose, insulin, and exercise through diverse pathways. PKC-zeta also plays a central role in maintaining cell polarity in yeast and mammalian cells. In addition, it affects actin remodeling in muscle cells. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. The aPKC-zeta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270768 [Multi-domain]  Cd Length: 357  Bit Score: 146.70  E-value: 1.14e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIE-HVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLY 79
Cdd:cd05617   42 IYAMKVVKKELVHDDEDIDWVQTEKHVFEQASsNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFY 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFHsfvngGTGYSFE 158
Cdd:cd05617  122 AAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEgLGPGDTTSTFCGTPNYIAPEILR-----GEEYGFS 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDIHSS----NAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRF-----SSLQD 229
Cdd:cd05617  197 VDWWALGVLMFEMMAGRSPFDIITDnpdmNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLgcqpqTGFSD 276
                        250       260
                 ....*....|....*....|....*.
gi 247269852 230 MQTAPSLAHVLWDDLSEKKVEPGFVP 255
Cdd:cd05617  277 IKSHTFFRSIDWDLLEKKQVTPPFKP 302
STKc_GRK2 cd14223
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2; STKs ...
1-268 1.17e-40

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK2, also called beta-adrenergic receptor kinase (beta-ARK) or beta-ARK1, is important in regulating several cardiac receptor responses. It plays a role in cardiac development and in hypertension. Deletion of GRK2 in mice results in embryonic lethality, caused by hypoplasia of the ventricular myocardium. GRK2 also plays important roles in the liver (as a regulator of portal blood pressure), in immune cells, and in the nervous system. Altered GRK2 expression has been reported in several disorders including major depression, schizophrenia, bipolar disorder, and Parkinsonism. GRK2 contains an N-terminal RGS homology (RH) domain, a central catalytic domain, and C-terminal pleckstrin homology (PH) domain that mediates PIP2 and G protein betagamma-subunit translocation to the membrane. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. TheGRK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271125 [Multi-domain]  Cd Length: 321  Bit Score: 145.96  E-value: 1.17e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRE---LEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVR 77
Cdd:cd14223   27 MYAMKCLDKKRIKMKQGETLALNErimLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEAEMR 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  78 LYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDgERATALAGTKPYMAPEIFHSfvngGTGYSF 157
Cdd:cd14223  107 FYAAEIILGLEHMHSRFVVYRDLKPANILLDEFGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVLQK----GVAYDS 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 158 EVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSL----QDMQTA 233
Cdd:cd14223  182 SADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCMgrgaQEVKEE 261
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 247269852 234 PSLAHVLWDDLSEKKVEPGFVPNKGRLHCDPTFEL 268
Cdd:cd14223  262 PFFRGLDWQMVFLQKYPPPLIPPRGEVNAADAFDI 296
STKc_GRK5 cd05632
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5; STKs ...
1-270 2.85e-40

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK5 is widely expressed in many tissues. It associates with the membrane though an N-terminal PIP2 binding domain and also binds phospholipids via its C-terminus. GRK5 deficiency is associated with early Alzheimer's disease in humans and mouse models. GRK5 also plays a crucial role in the pathogenesis of sporadic Parkinson's disease. It participates in the regulation and desensitization of PDGFRbeta, a receptor tyrosine kinase involved in a variety of downstream cellular effects including cell growth, chemotaxis, apoptosis, and angiogenesis. GRK5 also regulates Toll-like receptor 4, which is involved in innate and adaptive immunity. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270780 [Multi-domain]  Cd Length: 313  Bit Score: 144.73  E-value: 2.85e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ--NVQFSEDTVRL 78
Cdd:cd05632   29 MYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNmgNPGFEEERALF 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFE 158
Cdd:cd05632  109 YAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGESIRGRVGTVGYMAPEVLNN-----QRYTLS 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDIHSSNA----VESLVQLFSTVsvqYVPTWSKEMVALLRKLLTVNPEHRFSSLQ----DM 230
Cdd:cd05632  184 PDYWGLGCLIYEMIEGQSPFRGRKEKVkreeVDRRVLETEEV---YSAKFSEEAKSICKMLLTKDPKQRLGCQEegagEV 260
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 247269852 231 QTAPSLAHVLWDDLSEKKVEPGFVPNKGRLHCDPTFELEE 270
Cdd:cd05632  261 KRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQ 300
STKc_LKB1_CaMKK cd14008
Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent ...
1-228 1.91e-39

Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent Protein Kinase Kinase, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Both LKB1 and CaMKKs can phosphorylate and activate AMP-activated protein kinase (AMPK). LKB1, also called STK11, serves as a master upstream kinase that activates AMPK and most AMPK-like kinases. LKB1 and AMPK are part of an energy-sensing pathway that links cell energy to metabolism and cell growth. They play critical roles in the establishment and maintenance of cell polarity, cell proliferation, cytoskeletal organization, as well as T-cell metabolism, including T-cell development, homeostasis, and effector function. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMPK. Vertebrates contain two CaMKKs, CaMKK1 (or alpha) and CaMKK2 (or beta). CaMKK1 is involved in the regulation of glucose uptake in skeletal muscles. CaMKK2 is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. The LKB1/CaMKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270910 [Multi-domain]  Cd Length: 267  Bit Score: 141.15  E-value: 1.91e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNK-----------QQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEED--MFMVVDLLLGGDLRY--HL 65
Cdd:cd14008   20 LYAIKIFNKsrlrkrregknDRGKIKNALDDVRREIAIMKKLDHPNIVRLYEVIDDPESdkLYLVLEYCEGGPVMEldSG 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  66 QQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATII-KDGERATALAGTKPYMAPEI 144
Cdd:cd14008  100 DRVPPLPEETARKYFRDLVLGLEYLHENGIVHRDIKPENLLLTADGTVKISDFGVSEMFeDGNDTLQKTAGTPAFLAPEL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 145 FHSfvnGGTGYS-FEVDWWSVGVMAYELLRGWRPYDihSSNAVESLVQ-LFSTVSVQYVPTWSKEMVALLRKLLTVNPEH 222
Cdd:cd14008  180 CDG---DSKTYSgKAADIWALGVTLYCLVFGRLPFN--GDNILELYEAiQNQNDEFPIPPELSPELKDLLRRMLEKDPEK 254

                 ....*.
gi 247269852 223 RFSSLQ 228
Cdd:cd14008  255 RITLKE 260
STKc_MAST cd05609
Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine ...
2-223 1.94e-39

Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAST kinases contain an N-terminal domain of unknown function, a central catalytic domain, and a C-terminal PDZ domain that mediates protein-protein interactions. There are four mammalian MAST kinases, named MAST1-MAST4. MAST1 is also called syntrophin-associated STK (SAST) while MAST2 is also called MAST205. MAST kinases are cytoskeletal associated kinases of unknown function that are also expressed at neuromuscular junctions and postsynaptic densities. MAST1, MAST2, and MAST3 bind and phosphorylate the tumor suppressor PTEN, and may contribute to the regulation and stabilization of PTEN. MAST2 is involved in the regulation of the Fc-gamma receptor of the innate immune response in macrophages, and may also be involved in the regulation of the Na+/H+ exchanger NHE3. The MAST kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270760 [Multi-domain]  Cd Length: 280  Bit Score: 141.39  E-value: 1.94e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd05609   28 FAMKKINKQNLILRNQIQQVFVERDILTFAENPFVVSMYCSFETKRHLCMVMEYVEGGDCATLLKNIGPLPVDMARMYFA 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDF--------NIATIIKDG--ERAT------ALAGTKPYMAPEIF 145
Cdd:cd05609  108 ETVLALEYLHSYGIVHRDLKPDNLLITSMGHIKLTDFglskiglmSLTTNLYEGhiEKDTrefldkQVCGTPEYIAPEVI 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 146 HSfvnggTGYSFEVDWWSVGVMAYELLRGWRPYdihSSNAVEslvQLFSTVSVQYVpTWSKEMVA-------LLRKLLTV 218
Cdd:cd05609  188 LR-----QGYGKPVDWWAMGIILYEFLVGCVPF---FGDTPE---ELFGQVISDEI-EWPEGDDAlpddaqdLITRLLQQ 255

                 ....*
gi 247269852 219 NPEHR 223
Cdd:cd05609  256 NPLER 260
STKc_GRK1 cd05608
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1; STKs ...
1-256 2.49e-39

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK1 (also called rhodopsin kinase) belongs to the visual group of GRKs and is expressed in retinal cells. It phosphorylates rhodopsin in rod cells, which leads to termination of the phototransduction cascade. Mutations in GRK1 are associated to a recessively inherited form of stationary nightblindness called Oguchi disease. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270759 [Multi-domain]  Cd Length: 288  Bit Score: 141.17  E-value: 2.49e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL----QQNVQFSEDTV 76
Cdd:cd05608   28 LYACKKLNKKRLKKRKGYEGAMVEKRILAKVHSRFIVSLAYAFQTKTDLCLVMTIMNGGDLRYHIynvdEENPGFQEPRA 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  77 RLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERAT-ALAGTKPYMAPEIFHsfvngGTGY 155
Cdd:cd05608  108 CFYTAQIISGLEHLHQRRIIYRDLKPENVLLDDDGNVRISDLGLAVELKDGQTKTkGYAGTPGFMAPELLL-----GEEY 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 156 SFEVDWWSVGVMAYELLRGWRPYDIHSSNaVES--LVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRF----SSLQD 229
Cdd:cd05608  183 DYSVDYFTLGVTLYEMIAARGPFRARGEK-VENkeLKQRILNDSVTYSEKFSPASKSICEALLAKDPEKRLgfrdGNCDG 261
                        250       260
                 ....*....|....*....|....*..
gi 247269852 230 MQTAPSLAHVLWDDLSEKKVEPGFVPN 256
Cdd:cd05608  262 LRTHPFFRDINWRKLEAGILPPPFVPD 288
STKc_Nek cd08215
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase; ...
2-240 5.36e-39

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Nek family is composed of 11 different mammalian members (Nek1-11) with similarity to the catalytic domain of Aspergillus nidulans NIMA kinase, the founding member of the Nek family, which was identified in a screen for cell cycle mutants that were prevented from entering mitosis. Neks contain a conserved N-terminal catalytic domain and a more divergent C-terminal regulatory region of various sizes and structures. They are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270855 [Multi-domain]  Cd Length: 258  Bit Score: 139.52  E-value: 5.36e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQcIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ----NVQFSEDTVR 77
Cdd:cd08215   28 YVLKEIDLSN-MSEKEREEALNEVKLLSKLKHPNIVKYYESFEENGKLCIVMEYADGGDLAQKIKKqkkkGQPFPEEQIL 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  78 LYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIK-DGERATALAGTKPYMAPEIFHsfvngGTGYS 156
Cdd:cd08215  107 DWFVQICLALKYLHSRKILHRDLKTQNIFLTKDGVVKLGDFGISKVLEsTTDLAKTVVGTPYYLSPELCE-----NKPYN 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 157 FEVDWWSVGVMAYELLRGWRPYDihsSNAVESLVQlfSTVSVQYVP---TWSKEMVALLRKLLTVNPEHRfsslqdmqta 233
Cdd:cd08215  182 YKSDIWALGCVLYELCTLKHPFE---ANNLPALVY--KIVKGQYPPipsQYSSELRDLVNSMLQKDPEKR---------- 246

                 ....*..
gi 247269852 234 PSLAHVL 240
Cdd:cd08215  247 PSANEIL 253
STKc_cPKC_alpha cd05615
Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha; STKs ...
1-255 1.17e-38

Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-alpha is expressed in many tissues and is associated with cell proliferation, apoptosis, and cell motility. It plays a role in the signaling of the growth factors PDGF, VEGF, EGF, and FGF. Abnormal levels of PKC-alpha have been detected in many transformed cell lines and several human tumors. In addition, PKC-alpha is required for HER2 dependent breast cancer invasion. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, cPKCs depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. The cPKC-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270766 [Multi-domain]  Cd Length: 341  Bit Score: 140.90  E-value: 1.17e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHV-FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLY 79
Cdd:cd05615   37 LYAIKILKKDVVIQDDDVECTMVEKRVLALQDKPpFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFY 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATI-IKDGERATALAGTKPYMAPEIFhsfvnGGTGYSFE 158
Cdd:cd05615  117 AAEISVGLFFLHKKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEhMVEGVTTRTFCGTPDYIAPEII-----AYQPYGRS 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDIHSSnavESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQ----DMQTAP 234
Cdd:cd05615  192 VDWWAYGVLLYEMLAGQPPFDGEDE---DELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPegerDIREHA 268
                        250       260
                 ....*....|....*....|.
gi 247269852 235 SLAHVLWDDLSEKKVEPGFVP 255
Cdd:cd05615  269 FFRRIDWDKLENREIQPPFKP 289
STKc_GRK7 cd05607
Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7; ...
1-256 1.64e-38

Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK7 (also called iodopsin kinase) belongs to the visual group of GRKs. It is primarily found in the retina and plays a role in the regulation of opsin light receptors. GRK7 is located in retinal cone outer segments and plays an important role in regulating photoresponse of the cones. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270758 [Multi-domain]  Cd Length: 286  Bit Score: 139.27  E-value: 1.64e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRL-- 78
Cdd:cd05607   29 MYACKKLDKKRLKKKSGEKMALLEKEILEKVNSPFIVSLAYAFETKTHLCLVMSLMNGGDLKYHIYNVGERGIEMERVif 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFE 158
Cdd:cd05607  109 YSAQITCGILHLHSLKIVYRDMKPENVLLDDNGNCRLSDLGLAVEVKEGKPITQRAGTNGYMAPEILKE-----ESYSYP 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPY-DIHSSNAVESLVQ--LFSTVSVQYvPTWSKEMVALLRKLLTVNPEHRFSSLQ---DMQT 232
Cdd:cd05607  184 VDWFAMGCSIYEMVAGRTPFrDHKEKVSKEELKRrtLEDEVKFEH-QNFTEEAKDICRLFLAKKPENRLGSRTnddDPRK 262
                        250       260
                 ....*....|....*....|....
gi 247269852 233 APSLAHVLWDDLSEKKVEPGFVPN 256
Cdd:cd05607  263 HEFFKSINFPRLEAGLIDPPFVPD 286
STKc_STK36 cd14002
Catalytic domain of Serine/Threonine Kinase 36; STKs catalyze the transfer of the ...
3-225 4.26e-38

Catalytic domain of Serine/Threonine Kinase 36; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK36, also called Fused (or Fu) kinase, is involved in the Hedgehog signaling pathway. It is activated by the Smoothened (SMO) signal transducer, resulting in the stabilization of GLI transcription factors and the phosphorylation of SUFU to facilitate the nuclear accumulation of GLI. In Drosophila, Fused kinase is maternally required for proper segmentation during embryonic development and for the development of legs and wings during the larval stage. In mice, STK36 is not necessary for embryonic development, although mice deficient in STK36 display growth retardation postnatally. The STK36 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270904 [Multi-domain]  Cd Length: 253  Bit Score: 137.00  E-value: 4.26e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDeVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGgDLRYHLQQNVQFSEDTVRLYICE 82
Cdd:cd14002   30 ALKFIPKRGKSEKE-LRNLRQEIEILRKLNHPNIIEMLDSFETKKEFVVVTEYAQG-ELFQILEDDGTLPEEEVRSIAKQ 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAtiikdgeRA--------TALAGTKPYMAPEIFHSfvnggTG 154
Cdd:cd14002  108 LVSALHYLHSNRIIHRDMKPQNILIGKGGVVKLCDFGFA-------RAmscntlvlTSIKGTPLYMAPELVQE-----QP 175
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 247269852 155 YSFEVDWWSVGVMAYELLRGWRPYdihSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFS 225
Cdd:cd14002  176 YDHTADLWSLGCILYELFVGQPPF---YTNSIYQLVQMIVKDPVKWPSNMSPEFKSFLQGLLNKDPSKRLS 243
STKc_ATG1_ULK_like cd14009
Catalytic domain of the Serine/Threonine kinases, Autophagy-related protein 1 and Unc-51-like ...
3-225 6.77e-38

Catalytic domain of the Serine/Threonine kinases, Autophagy-related protein 1 and Unc-51-like kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes yeast ATG1 and metazoan homologs including vertebrate ULK1-3. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. It is involved in nutrient sensing and signaling, the assembly of autophagy factors and the execution of autophagy. In metazoans, ATG1 homologs display additional functions. Unc-51 and ULKs have been implicated in neuronal and axonal development. The ATG1/ULK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270911 [Multi-domain]  Cd Length: 251  Bit Score: 136.58  E-value: 6.77e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKymnkqqCIERDE-----VRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVR 77
Cdd:cd14009   22 AIK------EISRKKlnkklQENLESEIAILKSIKHPNIVRLYDVQKTEDFIYLVLEYCAGGDLSQYIRKRGRLPEAVAR 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  78 LYICEMALALDYLRSQHIIHRDVKPDNILLDEQG-HAHL--TDFNIATIIKDGERATALAGTKPYMAPEIFHSfvnggTG 154
Cdd:cd14009   96 HFMQQLASGLKFLRSKNIIHRDLKPQNLLLSTSGdDPVLkiADFGFARSLQPASMAETLCGSPLYMAPEILQF-----QK 170
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 247269852 155 YSFEVDWWSVGVMAYELLRGWRPYDihSSNAVESLVQLFSTVSVQYVP---TWSKEMVALLRKLLTVNPEHRFS 225
Cdd:cd14009  171 YDAKADLWSVGAILFEMLVGKPPFR--GSNHVQLLRNIERSDAVIPFPiaaQLSPDCKDLLRRLLRRDPAERIS 242
STKc_PhKG cd14093
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit; STKs ...
2-238 8.52e-38

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). Each subunit has tissue-specific isoforms or splice variants. Vertebrates contain two isoforms of the gamma subunit (gamma 1 and gamma 2). The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270995 [Multi-domain]  Cd Length: 272  Bit Score: 136.71  E-value: 8.52e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYM----NKQQCIERDEVRNVFR-ELEILQEIE-HVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDT 75
Cdd:cd14093   31 FAVKIIditgEKSSENEAEELREATRrEIEILRQVSgHPNIIELHDVFESPTFIFLVFELCRKGELFDYLTEVVTLSEKK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  76 VRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFH-SFVNGGTG 154
Cdd:cd14093  111 TRRIMRQLFEAVEFLHSLNIVHRDLKPENILLDDNLNVKISDFGFATRLDEGEKLRELCGTPGYLAPEVLKcSMYDNAPG 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 155 YSFEVDWWSVGVMAYELLRGWRPYdIHSsnavESLVQLFSTVSVQY---VPTW---SKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd14093  191 YGKEVDMWACGVIMYTLLAGCPPF-WHR----KQMVMLRNIMEGKYefgSPEWddiSDTAKDLISKLLVVDPKKRLTAEE 265
                        250
                 ....*....|
gi 247269852 229 dmqtapSLAH 238
Cdd:cd14093  266 ------ALEH 269
PTZ00426 PTZ00426
cAMP-dependent protein kinase catalytic subunit; Provisional
3-267 1.67e-37

cAMP-dependent protein kinase catalytic subunit; Provisional


Pssm-ID: 173616 [Multi-domain]  Cd Length: 340  Bit Score: 137.80  E-value: 1.67e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICE 82
Cdd:PTZ00426  60 AIKRFEKSKIIKQKQVDHVFSERKILNYINHPFCVNLYGSFKDESYLYLVLEFVIGGEFFTFLRRNKRFPNDVGCFYAAQ 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKdgERATALAGTKPYMAPEIfhsFVNGGTGYSfeVDWW 162
Cdd:PTZ00426 140 IVLIFEYLQSLNIVYRDLKPENLLLDKDGFIKMTDFGFAKVVD--TRTYTLCGTPEYIAPEI---LLNVGHGKA--ADWW 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 163 SVGVMAYELLRGWRPYdihssNAVESLVqLFSTV--SVQYVPTW-SKEMVALLRKLLTVNPEHRFSSL----QDMQTAPS 235
Cdd:PTZ00426 213 TLGIFIYEILVGCPPF-----YANEPLL-IYQKIleGIIYFPKFlDNNCKHLMKKLLSHDLTKRYGNLkkgaQNVKEHPW 286
                        250       260       270
                 ....*....|....*....|....*....|..
gi 247269852 236 LAHVLWDDLSEKKVEPGFVPNKGRLHCDPTFE 267
Cdd:PTZ00426 287 FGNIDWVSLLHKNVEVPYKPKYKNVFDSSNFE 318
STKc_MAPKKK cd06606
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase ...
1-228 1.93e-37

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPKKKs (MKKKs or MAP3Ks) are also called MAP/ERK kinase kinases (MEKKs) in some cases. They phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. This subfamily is composed of the Apoptosis Signal-regulating Kinases ASK1 (or MAPKKK5) and ASK2 (or MAPKKK6), MEKK1, MEKK2, MEKK3, MEKK4, as well as plant and fungal MAPKKKs. Also included in this subfamily are the cell division control proteins Schizosaccharomyces pombe Cdc7 and Saccharomyces cerevisiae Cdc15. The MAPKKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270783 [Multi-domain]  Cd Length: 258  Bit Score: 135.34  E-value: 1.93e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIErDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd06606   27 LMAVKEVELSGDSE-EELEALEREIRILSSLKHPNIVRYLGTERTENTLNIFLEYVPGGSLASLLKKFGKLPEPVVRKYT 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATA---LAGTKPYMAPEifhsfVNGGTGYSF 157
Cdd:cd06606  106 RQILEGLEYLHSNGIVHRDIKGANILVDSDGVVKLADFGCAKRLAEIATGEGtksLRGTPYWMAPE-----VIRGEGYGR 180
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 247269852 158 EVDWWSVGVMAYELLRGWRPYDiHSSNAVESLVQLFSTVSVQYVPTW-SKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd06606  181 AADIWSLGCTVIEMATGKPPWS-ELGNPVAALFKIGSSGEPPPIPEHlSEEAKDFLRKCLQRDPKKRPTADE 251
Pkinase pfam00069
Protein kinase domain;
1-231 2.01e-37

Protein kinase domain;


Pssm-ID: 459660 [Multi-domain]  Cd Length: 217  Bit Score: 134.29  E-value: 2.01e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852    1 MYAMKYMNKQQcIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:pfam00069  26 IVAIKKIKKEK-IKKKKDKNILREIKILKKLNHPNIVRLYDAFEDKDNLYLVLEYVEGGSLFDLLSEKGAFSEREAKFIM 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   81 CEMALALDYlrsqhiihrdvkpdnilldeqghahltdfniatiikdGERATALAGTKPYMAPEIFhsfvnGGTGYSFEVD 160
Cdd:pfam00069 105 KQILEGLES-------------------------------------GSSLTTFVGTPWYMAPEVL-----GGNPYGPKVD 142
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 247269852  161 WWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:pfam00069 143 VWSLGCILYELLTGKPPFPGINGNEIYELIIDQPYAFPELPSNLSEEAKDLLKKLLKKDPSKRLTATQALQ 213
STKc_NDR2 cd05627
Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2; STKs catalyze ...
1-247 1.32e-36

Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NDR2 (also called STK38-like) plays a role in proper centrosome duplication. In addition, it is involved in regulating neuronal growth and differentiation, as well as in facilitating neurite outgrowth. NDR2 is also implicated in fear conditioning as it contributes to the coupling of neuronal morphological changes with fear-memory consolidation. NDR kinase contains an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Like many other AGC kinases, NDR kinase requires phosphorylation at two sites, the activation loop (A-loop) and the hydrophobic motif (HM), for activity. The NDR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270776 [Multi-domain]  Cd Length: 366  Bit Score: 135.96  E-value: 1.32e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05627   29 IYAMKILRKADMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLSEEATQFYI 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGER------------------------------- 129
Cdd:cd05627  109 AETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRtefyrnlthnppsdfsfqnmnskrkaetwkk 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 130 -----ATALAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSV--QYVP 202
Cdd:cd05627  189 nrrqlAYSTVGTPDYIAPEVFMQ-----TGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVfpPEVP 263
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 247269852 203 TWSKEMVALLRklLTVNPEHRF--SSLQDMQTAPSLAHVLWDDLSEK 247
Cdd:cd05627  264 ISEKAKDLILR--FCTDAENRIgsNGVEEIKSHPFFEGVDWEHIRER 308
STKc_MASTL cd05610
Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like ...
1-255 5.13e-36

Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MASTL kinases in this group carry only a catalytic domain, which contains a long insertion relative to MAST kinases. MASTL, also called greatwall kinase (Gwl), is involved in the regulation of mitotic entry, which is controlled by the coordinated activities of protein kinases and opposing protein phosphatases (PPs). The cyclin B/CDK1 complex induces entry into M-phase while PP2A-B55 shows anti-mitotic activity. MASTL/Gwl is activated downstream of cyclin B/CDK1 and indirectly inhibits PP2A-B55 by phosphorylating the small protein alpha-endosulfine (Ensa) or the cAMP-regulated phosphoprotein 19 (Arpp19), resulting in M-phase progression. Gwl kinase may also play roles in mRNA stabilization and DNA checkpoint recovery. The human MASTL gene has also been named FLJ14813; a missense mutation in FLJ14813 is associated with autosomal dominant thrombocytopenia. The MASTL kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270761 [Multi-domain]  Cd Length: 349  Bit Score: 134.24  E-value: 5.13e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05610   31 LYAVKVVKKADMINKNMVHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYI 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDF-----------NIATIIK------------------------ 125
Cdd:cd05610  111 SEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFglskvtlnrelNMMDILTtpsmakpkndysrtpgqvlsliss 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 126 ----------------------DGERataLAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLRGWRPYDIhss 183
Cdd:cd05610  191 lgfntptpyrtpksvrrgaarvEGER---ILGTPDYLAPELLL-----GKPHGPAVDWWALGVCLFEFLTGIPPFND--- 259
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 247269852 184 navESLVQLFSTVSVQYVPtWSKEMVAL-------LRKLLTVNPEHRfSSLQDMQTAPSLAHVLWDDLSEKkvEPGFVP 255
Cdd:cd05610  260 ---ETPQQVFQNILNRDIP-WPEGEEELsvnaqnaIEILLTMDPTKR-AGLKELKQHPLFHGVDWENLQNQ--TMPFIP 331
STKc_ROCK1 cd05622
Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein ...
1-196 5.95e-36

Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ROCK1 is preferentially expressed in the liver, lung, spleen, testes, and kidney. It mediates signaling from Rho to the actin cytoskeleton. It is implicated in the development of cardiac fibrosis, cardiomyocyte apoptosis, and hyperglycemia. Mice deficient with ROCK1 display eyelids open at birth (EOB) and omphalocele phenotypes due to the disorganization of actin filaments in the eyelids and the umbilical ring. ROCK contains an N-terminal extension, a catalytic kinase domain, and a C-terminal extension, which contains a coiled-coil region encompassing a Rho-binding domain (RBD) and a pleckstrin homology (PH) domain. ROCK is auto-inhibited by the RBD and PH domain interacting with the catalytic domain, and is activated via interaction with Rho GTPases. The ROCK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270772 [Multi-domain]  Cd Length: 405  Bit Score: 135.13  E-value: 5.95e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLrYHLQQNVQFSEDTVRLYI 80
Cdd:cd05622  100 VYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDL-VNLMSNYDVPEKWARFYT 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATII-KDGE-RATALAGTKPYMAPEIFHSfvNGGTG-YSF 157
Cdd:cd05622  179 AEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMnKEGMvRCDTAVGTPDYISPEVLKS--QGGDGyYGR 256
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 247269852 158 EVDWWSVGVMAYELLRGWRPYdihssnAVESLVQLFSTV 196
Cdd:cd05622  257 ECDWWSVGVFLYEMLVGDTPF------YADSLVGTYSKI 289
STKc_PLK cd14099
Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases; STKs catalyze the ...
2-243 7.29e-36

Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. PLKs derive their names from homology to polo, a kinase first identified in Drosophila. There are five mammalian PLKs (PLK1-5) from distinct genes. There is good evidence that PLK1 may function as an oncogene while PLK2-5 have tumor suppressive properties. PLK1 functions as a positive regulator of mitosis, meiosis, and cytokinesis. PLK2 functions in G1 progression, S-phase arrest, and centriole duplication. PLK3 regulates angiogenesis and responses to DNA damage. PLK4 is required for late mitotic progression, cell survival, and embryonic development. PLK5 was first identified as a pseudogene containing a stop codon within the kinase domain, however, both murine and human genes encode expressed proteins. PLK5 functions in cell cycle arrest.


Pssm-ID: 271001 [Multi-domain]  Cd Length: 258  Bit Score: 131.14  E-value: 7.29e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd14099   29 YAGKVVPKSSLTKPKQREKLKSEIKIHRSLKHPNIVKFHDCFEDEENVYILLELCSNGSLMELLKRRKALTEPEVRYFMR 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIK-DGERATALAGTKPYMAPEIfhsfVNGGTGYSFEVD 160
Cdd:cd14099  109 QILSGVKYLHSNRIIHRDLKLGNLFLDENMNVKIGDFGLAARLEyDGERKKTLCGTPNYIAPEV----LEKKKGHSFEVD 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 161 WWSVGVMAYELLRGWRPYDihsSNAVESLVQlfSTVSVQYV----PTWSKEMVALLRKLLTVNPEHRfsslqdmqtaPSL 236
Cdd:cd14099  185 IWSLGVILYTLLVGKPPFE---TSDVKETYK--RIKKNEYSfpshLSISDEAKDLIRSMLQPDPTKR----------PSL 249

                 ....*..
gi 247269852 237 AHVLWDD 243
Cdd:cd14099  250 DEILSHP 256
STKc_PhKG2 cd14181
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit; STKs ...
7-231 1.01e-35

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). The gamma 2 subunit (PhKG2) is also referred to as the testis/liver gamma isoform. Mutations in its gene cause autosomal-recessive glycogenosis of the liver. The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271083 [Multi-domain]  Cd Length: 279  Bit Score: 131.63  E-value: 1.01e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   7 MNKQQCierDEVR-NVFRELEILQEIE-HVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMA 84
Cdd:cd14181   50 LSPEQL---EEVRsSTLKEIHILRQVSgHPSIITLIDSYESSTFIFLVFDLMRRGELFDYLTEKVTLSEKETRSIMRSLL 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  85 LALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFH-SFVNGGTGYSFEVDWWS 163
Cdd:cd14181  127 EAVSYLHANNIVHRDLKPENILLDDQLHIKLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKcSMDETHPGYGKEVDLWA 206
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 247269852 164 VGVMAYELLRGWRPYdIHSsnavESLVQLFSTVSVQY---VPTW---SKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd14181  207 CGVILFTLLAGSPPF-WHR----RQMLMLRMIMEGRYqfsSPEWddrSSTVKDLISRLLVVDPEIRLTAEQALQ 275
STKc_Rad53_Cds1 cd14098
Catalytic domain of the yeast Serine/Threonine Kinases, Rad53 and Cds1; STKs catalyze the ...
1-231 1.06e-35

Catalytic domain of the yeast Serine/Threonine Kinases, Rad53 and Cds1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Rad53 and Cds1 are the checkpoint kinase 2 (Chk2) homologs found in budding and fission yeast, respectively. They play a central role in the cell's response to DNA lesions to prevent genome rearrangements and maintain genome integrity. They are phosphorylated in response to DNA damage and incomplete replication, and are essential for checkpoint control. They help promote DNA repair by stalling the cell cycle prior to mitosis in the presence of DNA damage. The Rad53/Cds1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271000 [Multi-domain]  Cd Length: 265  Bit Score: 131.06  E-value: 1.06e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVF-RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLY 79
Cdd:cd14098   27 MRAIKQIVKRKVAGNDKNLQLFqREINILKSLEHPGIVRLIDWYEDDQHIYLVMEYVEGGDLMDFIMAWGAIPEQHAREL 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHL--TDFNIATIIKDGERATALAGTKPYMAPEIFHSF-VNGGTGYS 156
Cdd:cd14098  107 TKQILEAMAYTHSMGITHRDLKPENILITQDDPVIVkiSDFGLAKVIHTGTFLVTFCGTMAYLAPEILMSKeQNLQGGYS 186
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 247269852 157 FEVDWWSVGVMAYELLRGWRPYDihsSNAVESLVQLFSTVSVQYVP----TWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd14098  187 NLVDMWSVGCLVYVMLTGALPFD---GSSQLPVEKRIRKGRYTQPPlvdfNISEEAIDFILRLLDVDPEKRMTAAQALD 262
STKc_SnRK3 cd14663
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
2-232 1.43e-35

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK3 is represented in this cd. The SnRK3 group contains members also known as CBL-interacting protein kinase, salt overly sensitive 2, SOS3-interacting proteins and protein kinase S. These kinases interact with calcium-binding proteins such as SOS3, SCaBPs, and CBL proteins, and are involved in responses to salt stress and in sugar and ABA signaling. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271133 [Multi-domain]  Cd Length: 256  Bit Score: 130.60  E-value: 1.43e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd14663   28 VAIKIIDKEQVAREGMVEQIKREIAIMKLLRHPNIVELHEVMATKTKIFFVMELVTGGELFSKIAKNGRLKEDKARKYFQ 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIaTIIKDGERATAL----AGTKPYMAPEIFHSfvnggTGY-S 156
Cdd:cd14663  108 QLIDAVDYCHSRGVFHRDLKPENLLLDEDGNLKISDFGL-SALSEQFRQDGLlhttCGTPNYVAPEVLAR-----RGYdG 181
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 157 FEVDWWSVGVMAYELLRGWRPYDihSSNaVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQT 232
Cdd:cd14663  182 AKADIWSCGVILFVLLAGYLPFD--DEN-LMALYRKIMKGEFEYPRWFSPGAKSLIKRILDPNPSTRITVEQIMAS 254
STKc_PAK cd06614
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase; STKs catalyze the ...
3-228 1.77e-35

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs are implicated in the regulation of many cellular processes including growth factor receptor-mediated proliferation, cell polarity, cell motility, cell death and survival, and actin cytoskeleton organization. PAK deregulation is associated with tumor development. PAKs from higher eukaryotes are classified into two groups (I and II), according to their biochemical and structural features. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). Group II PAKs contain a PBD and a catalytic domain, but lack other motifs found in group I PAKs. Since group II PAKs do not contain an obvious AID, they may be regulated differently from group I PAKs. Group I PAKs interact with the SH3 containing proteins Nck, Grb2 and PIX; no such binding has been demonstrated for group II PAKs. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270789 [Multi-domain]  Cd Length: 255  Bit Score: 130.02  E-value: 1.77e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNkqqcIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQN-VQFSEDTVRlYIC 81
Cdd:cd06614   29 AIKKMR----LRKQNKELIINEILIMKECKHPNIVDYYDSYLVGDELWVVMEYMDGGSLTDIITQNpVRMNESQIA-YVC 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMAL-ALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATII-KDGERATALAGTkPY-MAPEifhsfVNGGTGYSFE 158
Cdd:cd06614  104 REVLqGLEYLHSQNVIHRDIKSDNILLSKDGSVKLADFGFAAQLtKEKSKRNSVVGT-PYwMAPE-----VIKRKDYGPK 177
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 159 VDWWSVGVMAYELLRGWRPYdihssnAVESLVQLFSTVSVQYVPT------WSKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd06614  178 VDIWSLGIMCIEMAEGEPPY------LEEPPLRALFLITTKGIPPlknpekWSPEFKDFLNKCLVKDPEKRPSAEE 247
STKc_NDR1 cd05628
Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1; STKs catalyze ...
1-178 4.11e-35

Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NDR1 (also called STK38) plays a role in proper centrosome duplication. It is highly expressed in thymus, muscle, lung and spleen. It is not an essential protein because mice deficient of NDR1 remain viable and fertile. However, these mice develop T-cell lymphomas and appear to be hypersenstive to carcinogenic treatment. NDR1 appears to also act as a tumor suppressor. NDR kinase contains an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Like many other AGC kinases, NDR kinase requires phosphorylation at two sites, the activation loop (A-loop) and the hydrophobic motif (HM), for activity. The NDR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270777 [Multi-domain]  Cd Length: 376  Bit Score: 132.47  E-value: 4.11e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05628   28 VYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYI 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGER------------------------------- 129
Cdd:cd05628  108 AETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRtefyrnlnhslpsdftfqnmnskrkaetwkr 187
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 247269852 130 -----ATALAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd05628  188 nrrqlAFSTVGTPDYIAPEVFMQ-----TGYNKLCDWWSLGVIMYEMLIGYPPF 236
STKc_MAP3K-like cd13999
Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine ...
3-230 6.82e-35

Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed mainly of MAP3Ks and similar proteins, including TGF-beta Activated Kinase-1 (TAK1, also called MAP3K7), MAP3K12, MAP3K13, Mixed lineage kinase (MLK), MLK-Like mitogen-activated protein Triple Kinase (MLTK), and Raf (Rapidly Accelerated Fibrosarcoma) kinases. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Also included in this subfamily is the pseudokinase Kinase Suppressor of Ras (KSR), which is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway.


Pssm-ID: 270901 [Multi-domain]  Cd Length: 245  Bit Score: 128.42  E-value: 6.82e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQciERDEVRNVF-RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQ-QNVQFSEDTVRLYI 80
Cdd:cd13999   20 AIKKLKVED--DNDELLKEFrREVSILSKLRHPNIVQFIGACLSPPPLCIVTEYMPGGSLYDLLHkKKIPLSWSLRLKIA 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATII-KDGERATALAGTKPYMAPEIFHsfvngGTGYSFEV 159
Cdd:cd13999   98 LDIARGMNYLHSPPIIHRDLKSLNILLDENFTVKIADFGLSRIKnSTTEKMTGVVGTPRWMAPEVLR-----GEPYTEKA 172
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 160 DWWSVGVMAYELLRGWRPYDIHSSNAVESLVqlfstVSVQYVPT----WSKEMVALLRKLLTVNPEHR--FSSLQDM 230
Cdd:cd13999  173 DVYSFGIVLWELLTGEVPFKELSPIQIAAAV-----VQKGLRPPippdCPPELSKLIKRCWNEDPEKRpsFSEIVKR 244
STKc_LATS2 cd05626
Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2; STKs ...
1-224 1.94e-34

Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LATS2 is an essential mitotic regulator responsible for coordinating accurate cytokinesis completion and governing the stabilization of other mitotic regulators. It is also critical in the maintenance of proper chromosome number, genomic stability, mitotic fidelity, and the integrity of centrosome duplication. Downregulation of LATS2 is associated with poor prognosis in acute lymphoblastic leukemia and breast cancer. The LATS2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173715 [Multi-domain]  Cd Length: 381  Bit Score: 130.52  E-value: 1.94e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05626   28 LYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMEVFPEVLARFYI 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAT----------------IIKD----------------GE 128
Cdd:cd05626  108 AELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTgfrwthnskyyqkgshIRQDsmepsdlwddvsncrcGD 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 129 R----------------ATALAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELLRGWRPYdiHSSNAVESLVQL 192
Cdd:cd05626  188 RlktleqratkqhqrclAHSLVGTPNYIAPEVLLR-----KGYTQLCDWWSVGVILFEMLVGQPPF--LAPTPTETQLKV 260
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 247269852 193 FSTVSVQYVPT---WSKEMVALLRKlLTVNPEHRF 224
Cdd:cd05626  261 INWENTLHIPPqvkLSPEAVDLITK-LCCSAEERL 294
STKc_ROCK2 cd05621
Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein ...
1-196 2.49e-34

Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ROCK2 was the first identified target of activated RhoA, and was found to play a role in stress fiber and focal adhesion formation. It is prominently expressed in the brain, heart, and skeletal muscles. It is implicated in vascular and neurological disorders, such as hypertension and vasospasm of the coronary and cerebral arteries. ROCK2 is also activated by caspase-2 cleavage, resulting in thrombin-induced microparticle generation in response to cell activation. Mice deficient in ROCK2 show intrauterine growth retardation and embryonic lethality because of placental dysfunction. ROCK contains an N-terminal extension, a catalytic kinase domain, and a C-terminal extension, which contains a coiled-coil region encompassing a Rho-binding domain (RBD) and a pleckstrin homology (PH) domain. ROCK is auto-inhibited by the RBD and PH domain interacting with the catalytic domain, and is activated via interaction with Rho GTPases. The ROCK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270771 [Multi-domain]  Cd Length: 379  Bit Score: 130.12  E-value: 2.49e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLrYHLQQNVQFSEDTVRLYI 80
Cdd:cd05621   79 VYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDKYLYMVMEYMPGGDL-VNLMSNYDVPEKWAKFYT 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFniATIIKDGE----RATALAGTKPYMAPEIFHSfvNGGTG-Y 155
Cdd:cd05621  158 AEVVLALDAIHSMGLIHRDVKPDNMLLDKYGHLKLADF--GTCMKMDEtgmvHCDTAVGTPDYISPEVLKS--QGGDGyY 233
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 247269852 156 SFEVDWWSVGVMAYELLRGWRPYdihssnAVESLVQLFSTV 196
Cdd:cd05621  234 GRECDWWSVGVFLFEMLVGDTPF------YADSLVGTYSKI 268
STKc_ULK3 cd14121
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3; STKs catalyze the ...
12-225 3.26e-34

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK3 mRNA is up-regulated in fibroblasts after Ras-induced senescence, and its overexpression induces both autophagy and senescence in a fibroblast cell line. ULK3, through its kinase activity, positively regulates Gli proteins, mediators of the Sonic hedgehog (Shh) signaling pathway that is implicated in tissue homeostasis maintenance and neurogenesis. It is inhibited by binding to Suppressor of Fused (Sufu). The ULK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271023 [Multi-domain]  Cd Length: 252  Bit Score: 126.63  E-value: 3.26e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  12 CIERDE-----VRNVFRELEILQEIEHVFLVNLwYSFQ-DEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMAL 85
Cdd:cd14121   28 CVSKSSlnkasTENLLTEIELLKKLKHPHIVEL-KDFQwDEEHIYLIMEYCSGGDLSRFIRSRRTLPESTVRRFLQQLAS 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  86 ALDYLRSQHIIHRDVKPDNILLDEQGHAHL--TDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWS 163
Cdd:cd14121  107 ALQFLREHNISHMDLKPQNLLLSSRYNPVLklADFGFAQHLKPNDEAHSLRGSPLYMAPEMIL-----KKKYDARVDLWS 181
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 247269852 164 VGVMAYELLRGWRPYdihSSNAVESL---VQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFS 225
Cdd:cd14121  182 VGVILYECLFGRAPF---ASRSFEELeekIRSSKPIEIPTRPELSADCRDLLLRLLQRDPDRRIS 243
STKc_DCKL3 cd14185
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called ...
2-231 5.24e-34

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called Doublecortin-like and CAM kinase-like 3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL3 (or DCAMKL3) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. DCKL3 contains a single DCX domain (instead of a tandem) and a C-terminal kinase domain with similarity to CAMKs. It has been shown to interact with tubulin and JIP1/2. The DCKL3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271087 [Multi-domain]  Cd Length: 258  Bit Score: 126.60  E-value: 5.24e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVrnVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd14185   28 YAMKIIDKSKLKGKEDM--IESEILIIKSLSHPNIVKLFEVYETEKEIYLILEYVRGGDLFDAIIESVKFTEHDAALMII 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILL----DEQGHAHLTDFNIATIIKdgERATALAGTKPYMAPEIFhsfvnGGTGYSF 157
Cdd:cd14185  106 DLCEALVYIHSKHIVHRDLKPENLLVqhnpDKSTTLKLADFGLAKYVT--GPIFTVCGTPTYVAPEIL-----SEKGYGL 178
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 158 EVDWWSVGVMAYELLRGWRPYDIHSSNAvESLVQLFSTVSVQYVPTW----SKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd14185  179 EVDMWAAGVILYILLCGFPPFRSPERDQ-EELFQIIQLGHYEFLPPYwdniSEAAKDLISRLLVVDPEKRYTAKQVLQ 255
STKc_GSK3 cd14137
The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; STKs catalyze ...
23-244 5.08e-33

The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GSK3 is a mutifunctional kinase involved in many cellular processes including cell division, proliferation, differentiation, adhesion, and apoptosis. In plants, GSK3 plays a role in the response to osmotic stress. In Caenorhabditis elegans, it plays a role in regulating normal oocyte-to-embryo transition and response to oxidative stress. In Chlamydomonas reinhardtii, GSK3 regulates flagellar length and assembly. In mammals, there are two isoforms, GSK3alpha and GSK3beta, which show both distinct and redundant functions. The two isoforms differ mainly in their N-termini. They are both involved in axon formation and in Wnt signaling.They play distinct roles in cardiogenesis, with GSKalpha being essential in cardiomyocyte survival, and GSKbeta regulating heart positioning and left-right symmetry. GSK3beta was first identified as a regulator of glycogen synthesis, but has since been determined to play other roles. It regulates the degradation of beta-catenin and IkB. Beta-catenin is the main effector of Wnt, which is involved in normal haematopoiesis and stem cell function. IkB is a central inhibitor of NF-kB, which is critical in maintaining leukemic cell growth. GSK3beta is enriched in the brain and is involved in regulating neuronal signaling pathways. It is implicated in the pathogenesis of many diseases including Type II diabetes, obesity, mood disorders, Alzheimer's disease, osteoporosis, and some types of cancer, among others. The GSK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271039 [Multi-domain]  Cd Length: 293  Bit Score: 124.54  E-value: 5.08e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSF------QDEEDMFMVVDLL---LGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQ 93
Cdd:cd14137   46 RELQIMRRLKHPNIVKLKYFFyssgekKDEVYLNLVMEYMpetLYRVIRHYSKNKQTIPIIYVKLYSYQLFRGLAYLHSL 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  94 HIIHRDVKPDNILLD-EQGHAHLTDFNIATIIKDGERATALAGTKPYMAPE-IFHSfvnggTGYSFEVDWWSVG-VMAyE 170
Cdd:cd14137  126 GICHRDIKPQNLLVDpETGVLKLCDFGSAKRLVPGEPNVSYICSRYYRAPElIFGA-----TDYTTAIDIWSAGcVLA-E 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 171 LLRGwRPY-----------------------DIHSSNaVESLVQLFSTVsvqYVPTWSK--------EMVALLRKLLTVN 219
Cdd:cd14137  200 LLLG-QPLfpgessvdqlveiikvlgtptreQIKAMN-PNYTEFKFPQI---KPHPWEKvfpkrtppDAIDLLSKILVYN 274
                        250       260
                 ....*....|....*....|....*
gi 247269852 220 PEHRFSSLQdmqtapSLAHVLWDDL 244
Cdd:cd14137  275 PSKRLTALE------ALAHPFFDEL 293
STKc_Aurora-A cd14116
Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase; STKs catalyze the transfer ...
3-234 4.21e-32

Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). Aurora-A regulates cell cycle events from the late S-phase through the M-phase including centrosome maturation, mitotic entry, centrosome separation, spindle assembly, chromosome alignment, cytokinesis, and mitotic exit. Aurora-A activation depends on its autophosphorylation and binding to the microtubule-associated protein TPX2, which also localizes the kinase to spindle microtubules. Aurora-A is overexpressed in many cancer types such as prostate, ovarian, breast, bladder, gastric, and pancreatic. The Aurora subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271018 [Multi-domain]  Cd Length: 258  Bit Score: 121.22  E-value: 4.21e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQcIERDEVRNVFR-ELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd14116   34 ALKVLFKAQ-LEKAGVEHQLRrEVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYIT 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNiATIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFEVDW 161
Cdd:cd14116  113 ELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFG-WSVHAPSSRRTTLCGTLDYLPPEMIE-----GRMHDEKVDL 186
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 247269852 162 WSVGVMAYELLRGWRPYDihsSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFsSLQDMQTAP 234
Cdd:cd14116  187 WSLGVLCYEFLVGKPPFE---ANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRP-MLREVLEHP 255
STKc_LATS1 cd05625
Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1; STKs catalyze the ...
1-224 4.86e-32

Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LATS1 functions as a tumor suppressor and is implicated in cell cycle regulation. Inactivation of LATS1 in mice results in the development of various tumors, including sarcomas and ovarian cancer. Promoter methylation, loss of heterozygosity, and missense mutations targeting the LATS1 gene have also been found in human sarcomas and ovarian cancers. In addition, decreased expression of LATS1 is associated with an aggressive phenotype and poor prognosis. LATS1 induces G2 arrest and promotes cytokinesis. It may be a component of the mitotic exit network in higher eukaryotes. The LATS1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270775 [Multi-domain]  Cd Length: 382  Bit Score: 124.00  E-value: 4.86e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd05625   28 LYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGVFPEDLARFYI 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATII--------------------------------KDGE 128
Cdd:cd05625  108 AELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFrwthdskyyqsgdhlrqdsmdfsnewgdpencRCGD 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 129 R----------------ATALAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELLRGWRPYdiHSSNAVESLVQL 192
Cdd:cd05625  188 RlkplerraarqhqrclAHSLVGTPNYIAPEVLLR-----TGYTQLCDWWSVGVILFEMLVGQPPF--LAQTPLETQMKV 260
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 247269852 193 FSTVSVQYVPTWSK---EMVALLRKLLTvNPEHRF 224
Cdd:cd05625  261 INWQTSLHIPPQAKlspEASDLIIKLCR-GPEDRL 294
STKc_Chk1 cd14069
Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1; STKs catalyze the ...
2-225 6.32e-32

Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chk1 is implicated in many major checkpoints of the cell cycle, providing a link between upstream sensors and the cell cycle engine. It plays an important role in DNA damage response and maintaining genomic stability. Chk1 acts as an effector of the sensor kinase, ATR (ATM and Rad3-related), a member of the PI3K family, which is activated upon DNA replication stress. Chk1 delays mitotic entry in response to replication blocks by inhibiting cyclin dependent kinase (Cdk) activity. In addition, Chk1 contributes to the function of centrosome and spindle-based checkpoints, inhibits firing of origins of DNA replication (Ori), and represses transcription of cell cycle proteins including cyclin B and Cdk1. The Chk1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270971 [Multi-domain]  Cd Length: 261  Bit Score: 120.90  E-value: 6.32e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCiERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd14069   29 VAVKFVDMKRA-PGDCPENIKKEVCIQKMLSHKNVVRFYGHRREGEFQYLFLEYASGGELFDKIEPDVGMPEDVAQFYFQ 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAT--IIKDGERA-TALAGTKPYMAPEIFhsfvnGGTGYSFE 158
Cdd:cd14069  108 QLMAGLKYLHSCGITHRDIKPENLLLDENDNLKISDFGLATvfRYKGKERLlNKMCGTLPYVAPELL-----AKKKYRAE 182
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 247269852 159 -VDWWSVGVMAYELLRGWRPYDIHSSNAVESLvqLFSTVSVQYVPTWSK---EMVALLRKLLTVNPEHRFS 225
Cdd:cd14069  183 pVDVWSCGIVLFAMLAGELPWDQPSDSCQEYS--DWKENKKTYLTPWKKidtAALSLLRKILTENPNKRIT 251
STKc_NUAK2 cd14161
Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2; STKs ...
3-232 1.06e-31

Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NUAK proteins are classified as AMP-activated protein kinase (AMPK)-related kinases, which like AMPK are activated by the major tumor suppressor LKB1. Vertebrates contain two NUAK proteins, called NUAK1 and NUAK2. NUAK2, also called SNARK (Sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase), is involved in energy metabolism. It is activated by hyperosmotic stress, DNA damage, and nutrients such as glucose and glutamine. NUAK2-knockout mice develop obesity, altered serum lipid profiles, hyperinsulinaemia, hyperglycaemia, and impaired glucose tolerance. NUAK2 is implicated in regulating actin stress fiber assembly through its association with myosin phosphatase Rho-interacting protein (MRIP), which leads to an increase in myosin regulatory light chain (MLC) phosphorylation. It is also associated with tumor growth, migration, and oncogenicity of melanoma cells. The NUAK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271063 [Multi-domain]  Cd Length: 255  Bit Score: 120.06  E-value: 1.06e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICE 82
Cdd:cd14161   31 AIKSIRKDRIKDEQDLLHIRREIEIMSSLNHPHIISVYEVFENSSKIVIVMEYASRGDLYDYISERQRLSELEARHFFRQ 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIfhsfVNGGTGYSFEVDWW 162
Cdd:cd14161  111 IVSAVHYCHANGIVHRDLKLENILLDANGNIKIADFGLSNLYNQDKFLQTYCGSPLYASPEI----VNGRPYIGPEVDSW 186
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 163 SVGVMAYELLRGWRPYDIHSSnavESLVQLFSTVSVQYvPTWSKEMVALLRKLLTVNPEHRfSSLQDMQT 232
Cdd:cd14161  187 SLGVLLYILVHGTMPFDGHDY---KILVKQISSGAYRE-PTKPSDACGLIRWLLMVNPERR-ATLEDVAS 251
STKc_NUAK cd14073
Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK; STKs catalyze ...
1-223 1.18e-31

Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NUAK proteins are classified as AMP-activated protein kinase (AMPK)-related kinases, which like AMPK are activated by the major tumor suppressor LKB1. Vertebrates contain two NUAK proteins, called NUAK1 and NUAK2. NUAK1, also called ARK5 (AMPK-related protein kinase 5), regulates cell proliferation and displays tumor suppression through direct interaction and phosphorylation of p53. It is also involved in cell senescence and motility. High NUAK1 expression is associated with invasiveness of nonsmall cell lung cancer (NSCLC) and breast cancer cells. NUAK2, also called SNARK (Sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase), is involved in energy metabolism. It is activated by hyperosmotic stress, DNA damage, and nutrients such as glucose and glutamine. NUAK2-knockout mice develop obesity, altered serum lipid profiles, hyperinsulinaemia, hyperglycaemia, and impaired glucose tolerance. The NUAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270975 [Multi-domain]  Cd Length: 254  Bit Score: 119.80  E-value: 1.18e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14073   28 EVAIKSIKKDKIEDEQDMVRIRREIEIMSSLNHPHIIRIYEVFENKDKIVIVMEYASGGELYDYISERRRLPEREARRIF 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIfhsfVNGGTGYSFEVD 160
Cdd:cd14073  108 RQIVSAVHYCHKNGVVHRDLKLENILLDQNGNAKIADFGLSNLYSKDKLLQTFCGSPLYASPEI----VNGTPYQGPEVD 183
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 247269852 161 WWSVGVMAYELLRGWRPYDIHSSNaveSLVQLFStvSVQYV-PTWSKEMVALLRKLLTVNPEHR 223
Cdd:cd14073  184 CWSLGVLLYTLVYGTMPFDGSDFK---RLVKQIS--SGDYRePTQPSDASGLIRWMLTVNPKRR 242
STKc_Mnk cd14090
Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase ...
2-178 1.24e-31

Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase signal-integrating kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270992 [Multi-domain]  Cd Length: 289  Bit Score: 120.98  E-value: 1.24e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERdevRNVFRELEILQEIE-HVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14090   30 YAVKIIEKHPGHSR---SRVFREVETLHQCQgHPNILQLIEYFEDDERFYLVFEKMRGGPLLSHIEKRVHFTEQEASLVV 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNIL---LDEQGHAHLTDFNIATIIKD-GERATALA--------GTKPYMAPEIFHSF 148
Cdd:cd14090  107 RDIASALDFLHDKGIAHRDLKPENILcesMDKVSPVKICDFDLGSGIKLsSTSMTPVTtpelltpvGSAEYMAPEVVDAF 186
                        170       180       190
                 ....*....|....*....|....*....|
gi 247269852 149 VNGGTGYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd14090  187 VGEALSYDKRCDLWSLGVILYIMLCGYPPF 216
STKc_PhKG1 cd14182
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 1 subunit; STKs ...
2-226 1.32e-31

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 1 subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). The gamma 1 subunit (PhKG1) is also referred to as the muscle gamma isoform. The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271084 [Multi-domain]  Cd Length: 276  Bit Score: 120.40  E-value: 1.32e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYM-----NKQQCIERDEVRN-VFRELEILQEIE-HVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSED 74
Cdd:cd14182   31 YAVKIIditggGSFSPEEVQELREaTLKEIDILRKVSgHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  75 TVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFH-SFVNGGT 153
Cdd:cd14182  111 ETRKIMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPGYLAPEIIEcSMDDNHP 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 154 GYSFEVDWWSVGVMAYELLRGWRPYdIHSSNAVesLVQLFSTVSVQY-VPTW---SKEMVALLRKLLTVNPEHRFSS 226
Cdd:cd14182  191 GYGKEVDMWSTGVIMYTLLAGSPPF-WHRKQML--MLRMIMSGNYQFgSPEWddrSDTVKDLISRFLVVQPQKRYTA 264
STKc_AMPK_alpha cd14079
Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein ...
3-223 7.49e-31

Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. AMPK, also called SNF1 (sucrose non-fermenting1) in yeasts and SnRK1 (SNF1-related kinase1) in plants, is a heterotrimeric enzyme composed of a catalytic alpha subunit and two regulatory subunits, beta and gamma. It is a stress-activated kinase that serves as master regulator of glucose and lipid metabolism by monitoring carbon and energy supplies, via sensing the cell's AMP:ATP ratio. In response to decreased ATP levels, it enhances energy-producing processes and inhibits energy-consuming pathways. Once activated, AMPK phosphorylates a broad range of downstream targets, with effects in carbohydrate metabolism and uptake, lipid and fatty acid biosynthesis, carbon energy storage, and inflammation, among others. Defects in energy homeostasis underlie many human diseases including Type 2 diabetes, obesity, heart disease, and cancer. As a result, AMPK has emerged as a therapeutic target in the treatment of these diseases. The AMPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270981 [Multi-domain]  Cd Length: 256  Bit Score: 117.75  E-value: 7.49e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICE 82
Cdd:cd14079   31 AVKILNRQKIKSLDMEEKIRREIQILKLFRHPHIIRLYEVIETPTDIFMVMEYVSGGELFDYIVQKGRLSEDEARRFFQQ 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIfhsfVNGGTGYSFEVDWW 162
Cdd:cd14079  111 IISGVEYCHRHMVVHRDLKPENLLLDSNMNVKIADFGLSNIMRDGEFLKTSCGSPNYAAPEV----ISGKLYAGPEVDVW 186
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 247269852 163 SVGVMAYELLRGWRPYDihssnaVESLVQLFSTVS--VQYVPTW-SKEMVALLRKLLTVNPEHR 223
Cdd:cd14079  187 SCGVILYALLCGSLPFD------DEHIPNLFKKIKsgIYTIPSHlSPGARDLIKRMLVVDPLKR 244
STKc_STK33 cd14097
Catalytic domain of Serine/Threonine Kinase 33; STKs catalyze the transfer of the ...
2-228 1.15e-30

Catalytic domain of Serine/Threonine Kinase 33; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK33 is highly expressed in the testis and is present in low levels in most tissues. It may be involved in spermatogenesis and organ ontogenesis. It interacts with and phosphorylates vimentin and may be involved in regulating intermediate filament cytoskeletal dynamics. Its role in promoting the cell viability of KRAS-dependent cancer cells is under debate; some studies have found STK33 to promote cancer cell viability, while other studies have found it to be non-essential. KRAS is the most commonly mutated human oncogene, thus, studies on the role of STK33 in KRAS mutant cancer cells are important. The STK33 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270999 [Multi-domain]  Cd Length: 266  Bit Score: 117.65  E-value: 1.15e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCiERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd14097   29 WAIKKINREKA-GSSAVKLLEREVDILKHVNHAHIIHLEEVFETPKRMYLVMELCEDGELKELLLRKGFFSENETRHIIQ 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILL-------DEQGHAHLTDFNIATIIKDGERA--TALAGTKPYMAPEIFhsfvnGG 152
Cdd:cd14097  108 SLASAVAYLHKNDIVHRDLKLENILVkssiidnNDKLNIKVTDFGLSVQKYGLGEDmlQETCGTPIYMAPEVI-----SA 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 153 TGYSFEVDWWSVGVMAYELLRGWRPYdihSSNAVESLVQLFSTVSVQYV-PTW---SKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd14097  183 HGYSQQCDIWSIGVIMYMLLCGEPPF---VAKSEEKLFEEIRKGDLTFTqSVWqsvSDAAKNVLQQLLKVDPAHRMTASE 259
STKc_TLK cd13990
Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; STKs catalyze the ...
9-228 3.00e-30

Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TLKs play important functions during the cell cycle and are implicated in chromatin remodeling, DNA replication and repair, and mitosis. They phosphorylate and regulate Anti-silencing function 1 protein (Asf1), a histone H3/H4 chaperone that helps facilitate the assembly of chromatin following DNA replication during S phase. TLKs also phosphorylate the H3 histone tail and are essential in transcription. Vertebrates contain two subfamily members, TLK1 and TLK2. The TLK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270892 [Multi-domain]  Cd Length: 279  Bit Score: 117.03  E-value: 3.00e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   9 KQQCIERdevrnVFRELEILQEIEHVFLVNLWYSFQDEEDMFM-VVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALAL 87
Cdd:cd13990   44 KQNYIKH-----ALREYEIHKSLDHPRIVKLYDVFEIDTDSFCtVLEYCDGNDLDFYLKQHKSIPEREARSIIMQVVSAL 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  88 DYL--RSQHIIHRDVKPDNILLDEQ---GHAHLTDFNIATIIKDG-------ERATALAGTKPYMAPEIFHSfvnGGTG- 154
Cdd:cd13990  119 KYLneIKPPIIHYDLKPGNILLHSGnvsGEIKITDFGLSKIMDDEsynsdgmELTSQGAGTYWYLPPECFVV---GKTPp 195
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 155 -YSFEVDWWSVGVMAYELLRGWRPYDIHSSNA--VESLVQLFST-VSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd13990  196 kISSKVDVWSVGVIFYQMLYGRKPFGHNQSQEaiLEENTILKATeVEFPSKPVVSSEAKDFIRRCLTYRKEDRPDVLQ 273
STKc_ULK1 cd14202
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1; STKs catalyze the ...
3-216 4.65e-30

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK1 is required for efficient amino acid starvation-induced autophagy and mitochondrial clearance. It associates with three autophagy-related proteins (Atg13, FIP200 amd Atg101) to form the ULK1 complex. All fours proteins are essential for autophagosome formation. ULK1 is regulated by both mammalian target-of rapamycin complex 1 (mTORC1) and AMP-activated protein kinase (AMPK). mTORC1 negatively regulates the ULK1 complex in a nutrient-dependent manner while AMPK stimulates autophagy by inhibiting mTORC1. ULK1 also plays neuron-specific roles and is involved in non-clathrin-coated endocytosis in growth cones, filopodia extension, neurite extension, and axon branching. The ULK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271104 [Multi-domain]  Cd Length: 267  Bit Score: 116.26  E-value: 4.65e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVrnVFRELEILQEIEHVFLVNLwYSFQD-EEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd14202   32 AVKCINKKNLAKSQTL--LGKEIKILKELKHENIVAL-YDFQEiANSVYLVMEYCNGGDLADYLHTMRTLSEDTIRLFLQ 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQG---------HAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSfvngg 152
Cdd:cd14202  109 QIAGAMKMLHSKGIIHRDLKPQNILLSYSGgrksnpnniRIKIADFGFARYLQNNMMAATLCGSPMYMAPEVIMS----- 183
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 247269852 153 TGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAveslVQLFSTVSVQYVPTWSKEMVALLRKLL 216
Cdd:cd14202  184 QHYDAKADLWSIGTIIYQCLTGKAPFQASSPQD----LRLFYEKNKSLSPNIPRETSSHLRQLL 243
STKc_MLCK-like cd14006
Catalytic kinase domain of Myosin Light Chain Kinase-like Serine/Threonine Kinases; STKs ...
2-238 1.33e-29

Catalytic kinase domain of Myosin Light Chain Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This family is composed of MLCKs and related MLCK-like kinase domains from giant STKs such as titin, obscurin, SPEG, Unc-89, Trio, kalirin, and Twitchin. Also included in this family are Death-Associated Protein Kinases (DAPKs) and Death-associated protein kinase-Related Apoptosis-inducing protein Kinase (DRAKs). MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. Titin, obscurin, Twitchin, and SPEG are muscle proteins involved in the contractile apparatus. The giant STKs are multidomain proteins containing immunoglobulin (Ig), fibronectin type III (FN3), SH3, RhoGEF, PH and kinase domains. Titin, obscurin, Twitchin, and SPEG contain many Ig domain repeats at the N-terminus, while Trio and Kalirin contain spectrin-like repeats. The MLCK-like family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270908 [Multi-domain]  Cd Length: 247  Bit Score: 114.29  E-value: 1.33e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKqqcieRDEVR-NVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14006   21 FAAKFIPK-----RDKKKeAVLREISILNQLQHPRIIQLHEAYESPTELVLILELCSGGELLDRLAERGSLSEEEVRTYM 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAH--LTDFNIATIIKDGERATALAGTKPYMAPEIfhsfVNgGTGYSFE 158
Cdd:cd14006   96 RQLLEGLQYLHNHHILHLDLKPENILLADRPSPQikIIDFGLARKLNPGEELKEIFGTPEFVAPEI----VN-GEPVSLA 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYdiHSSNAVESLVQLfSTVSVQYVPTW----SKEMVALLRKLLTVNPEHRfsslqdMQTAP 234
Cdd:cd14006  171 TDMWSIGVLTYVLLSGLSPF--LGEDDQETLANI-SACRVDFSEEYfssvSQEAKDFIRKLLVKEPRKR------PTAQE 241

                 ....
gi 247269852 235 SLAH 238
Cdd:cd14006  242 ALQH 245
STKc_ULK1_2-like cd14120
Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar ...
23-225 1.38e-29

Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK1 is required for efficient amino acid starvation-induced autophagy and mitochondrial clearance. ULK2 is ubiquitously expressed and is essential in autophagy induction. ULK1 and ULK2 have unique and cell-type specific roles, but also display partially redundant roles in starvation-induced autophagy. They both display neuron-specific functions: ULK1 is involved in non-clathrin-coated endocytosis in growth cones, filopodia extension, and axon branching; ULK2 plays a role in axon development. The ULK1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271022 [Multi-domain]  Cd Length: 256  Bit Score: 114.39  E-value: 1.38e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLwYSFQDEED-MFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVK 101
Cdd:cd14120   41 KEIKILKELSHENVVAL-LDCQETSSsVYLVMEYCNGGDLADYLQAKGTLSEDTIRVFLQQIAAAMKALHSKGIVHRDLK 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 102 PDNILLDEQGHAH---------LTDFNIATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELL 172
Cdd:cd14120  120 PQNILLSHNSGRKpspndirlkIADFGFARFLQDGMMAATLCGSPMYMAPEVIMS-----LQYDAKADLWSIGTIVYQCL 194
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 247269852 173 RGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFS 225
Cdd:cd14120  195 TGKAPFQAQTPQELKAFYEKNANLRPNIPSGTSPALKDLLLGLLKRNPKDRID 247
STKc_DCKL2 cd14184
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called ...
2-228 1.43e-29

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL2 (or DCAMKL2) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL2 contains a serine, threonine, and proline rich domain (SP) and a C-terminal kinase domain with similarity to CAMKs. DCKL2 has been shown to interact with tubulin, JIP1/2, JNK, neurabin 2, and actin. It is associated with the terminal segments of axons and dendrites, and may function as a phosphorylation-dependent switch to control microtubule dynamics in neuronal growth cones. The DCKL2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271086 [Multi-domain]  Cd Length: 259  Bit Score: 114.74  E-value: 1.43e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVrnVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd14184   29 FALKIIDKAKCCGKEHL--IENEVSILRRVKHPNIIMLIEEMDTPAELYLVMELVKGGDLFDAITSSTKYTERDASAMVY 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILL----DEQGHAHLTDFNIATIIkDGERATaLAGTKPYMAPEIFHSfvnggTGYSF 157
Cdd:cd14184  107 NLASALKYLHGLCIVHRDIKPENLLVceypDGTKSLKLGDFGLATVV-EGPLYT-VCGTPTYVAPEIIAE-----TGYGL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 158 EVDWWSVGVMAYELLRGWRPYdiHSSNAVESlvQLFSTVSVQYV----PTW------SKEMVALlrkLLTVNPEHRFSSL 227
Cdd:cd14184  180 KVDIWAAGVITYILLCGFPPF--RSENNLQE--DLFDQILLGKLefpsPYWdnitdsAKELISH---MLQVNVEARYTAE 252

                 .
gi 247269852 228 Q 228
Cdd:cd14184  253 Q 253
STKc_TSSK-like cd14080
Catalytic domain of testis-specific serine/threonine kinases and similar proteins; STKs ...
23-225 1.87e-29

Catalytic domain of testis-specific serine/threonine kinases and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK1 and TSSK2 are expressed specifically in meiotic and postmeiotic spermatogenic cells, respectively. TSSK3 has been reported to be expressed in the interstitial Leydig cells of adult testis. TSSK4, also called TSSK5, is expressed in testis from haploid round spermatids to mature spermatozoa. TSSK6, also called SSTK, is expressed at the head of elongated sperm. TSSK1/TSSK2 double knock-out and TSSK6 null mice are sterile without manifesting other defects, making these kinases viable targets for male contraception. The TSSK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270982 [Multi-domain]  Cd Length: 262  Bit Score: 114.20  E-value: 1.87e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKP 102
Cdd:cd14080   51 RELEILRKLRHPNIIQVYSIFERGSKVFIFMEYAEHGDLLEYIQKRGALSESQARIWFRQLALAVQYLHSLDIAHRDLKC 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 103 DNILLDEQGHAHLTDFNIATIIKDGERAT---ALAGTKPYMAPEIFHsfvngGTGYSFEV-DWWSVGVMAYELLRGWRPY 178
Cdd:cd14080  131 ENILLDSNNNVKLSDFGFARLCPDDDGDVlskTFCGSAAYAAPEILQ-----GIPYDPKKyDIWSLGVILYIMLCGSMPF 205
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 247269852 179 DihSSNaVESLVQLFSTVSVQYVPT---WSKEMVALLRKLLTVNPEHRFS 225
Cdd:cd14080  206 D--DSN-IKKMLKDQQNRKVRFPSSvkkLSPECKDLIDQLLEPDPTKRAT 252
STKc_BRSK1_2 cd14081
Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2; STKs catalyze the ...
3-225 1.89e-29

Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BRSK1, also called SAD-B or SAD1 (Synapses of Amphids Defective homolog 1), and BRSK2, also called SAD-A, are highly expressed in mammalian forebrain. They play important roles in establishing neuronal polarity. BRSK1/2 double knock-out mice die soon after birth, showing thin cerebral cortices due to disordered subplate layers and neurons that lack distinct axons and dendrites. BRSK1 regulates presynaptic neurotransmitter release. Its activity fluctuates during cell cysle progression and it acts as a regulator of centrosome duplication. BRSK2 is also abundant in pancreatic islets, where it is involved in the regulation of glucose-stimulated insulin secretion. The BRSK1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270983 [Multi-domain]  Cd Length: 255  Bit Score: 113.89  E-value: 1.89e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICE 82
Cdd:cd14081   30 AIKIVNKEKLSKESVLMKVEREIAIMKLIEHPNVLKLYDVYENKKYLYLVLEYVSGGELFDYLVKKGRLTEKEARKFFRQ 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIfhsfVNGGTGYSFEVDWW 162
Cdd:cd14081  110 IISALDYCHSHSICHRDLKPENLLLDEKNNIKIADFGMASLQPEGSLLETSCGSPHYACPEV----IKGEKYDGRKADIW 185
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 163 SVGVMAYELLRGWRPYDihssnaVESLVQLFSTVSV-QYV-PTW-SKEMVALLRKLLTVNPEHRFS 225
Cdd:cd14081  186 SCGVILYALLVGALPFD------DDNLRQLLEKVKRgVFHiPHFiSPDAQDLLRRMLEVNPEKRIT 245
STKc_MAP4K3_like cd06613
Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like ...
14-223 2.58e-29

Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes MAP4K3, MAP4K1, MAP4K2, MAP4K5, and related proteins. Vertebrate members contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4K1, also called haematopoietic progenitor kinase 1 (HPK1), is a hematopoietic-specific STK involved in many cellular signaling cascades including MAPK, antigen receptor, apoptosis, growth factor, and cytokine signaling. It participates in the regulation of T cell receptor signaling and T cell-mediated immune responses. MAP4K2 was referred to as germinal center (GC) kinase because of its preferred location in GC B cells. MAP4K3 plays a role in the nutrient-responsive pathway of mTOR (mammalian target of rapamycin) signaling. It is required in the activation of S6 kinase by amino acids and for the phosphorylation of the mTOR-regulated inhibitor of eukaryotic initiation factor 4E. MAP4K5, also called germinal center kinase-related enzyme (GCKR), has been shown to activate the MAPK c-Jun N-terminal kinase (JNK). The MAP4K3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270788 [Multi-domain]  Cd Length: 259  Bit Score: 113.94  E-value: 2.58e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  14 ERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRlYICEMAL-ALDYLRS 92
Cdd:cd06613   37 PGDDFEIIQQEISMLKECRHPNIVAYFGSYLRRDKLWIVMEYCGGGSLQDIYQVTGPLSELQIA-YVCRETLkGLAYLHS 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKD--GERATaLAGTKPYMAPEIFHsfVNGGTGYSFEVDWWSVGVMAYE 170
Cdd:cd06613  116 TGKIHRDIKGANILLTEDGDVKLADFGVSAQLTAtiAKRKS-FIGTPYWMAPEVAA--VERKGGYDGKCDIWALGITAIE 192
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 247269852 171 LLRGWRP-YDIHSSNAveslvqLFSTVSVQYVP-------TWSKEMVALLRKLLTVNPEHR 223
Cdd:cd06613  193 LAELQPPmFDLHPMRA------LFLIPKSNFDPpklkdkeKWSPDFHDFIKKCLTKNPKKR 247
PKc_MAPKK_plant_like cd06623
Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and ...
1-231 2.70e-29

Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include MAPKKs from plants, kinetoplastids, alveolates, and mycetozoa. The MAPKK, LmxPK4, from Leishmania mexicana, is important in differentiation and virulence. Dictyostelium discoideum MEK1 is required for proper chemotaxis; MEK1 null mutants display severe defects in cell polarization and directional movement. Plants contain multiple MAPKKs like other eukaryotes. The Arabidopsis genome encodes for 10 MAPKKs while poplar and rice contain 13 MAPKKs each. The functions of these proteins have not been fully elucidated. There is evidence to suggest that MAPK cascades are involved in plant stress responses. In Arabidopsis, MKK3 plays a role in pathogen signaling; MKK2 is involved in cold and salt stress signaling; MKK4/MKK5 participates in innate immunity; and MKK7 regulates basal and systemic acquired resistance. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132954 [Multi-domain]  Cd Length: 264  Bit Score: 113.84  E-value: 2.70e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKymnKQQCIERDEVRN-VFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLY 79
Cdd:cd06623   28 IYALK---KIHVDGDEEFRKqLLRELKTLRSCESPYVVKCYGAFYKEGEISIVLEYMDGGSLADLLKKVGKIPEPVLAYI 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQ-HIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDG--ERATALaGTKPYMAPEIFhsfvNGGTgYS 156
Cdd:cd06623  105 ARQILKGLDYLHTKrHIIHRDIKPSNLLINSKGEVKIADFGISKVLENTldQCNTFV-GTVTYMSPERI----QGES-YS 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 157 FEVDWWSVGVMAYELLRGWRPYdihSSNAVESLVQLFSTVSVQYVPTW-----SKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd06623  179 YAADIWSLGLTLLECALGKFPF---LPPGQPSFFELMQAICDGPPPSLpaeefSPEFRDFISACLQKDPKKRPSAAELLQ 255
STKc_OSR1_SPAK cd06610
Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and ...
3-178 5.55e-29

Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SPAK is also referred to as STK39 or PASK (proline-alanine-rich STE20-related kinase). OSR1 and SPAK regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. They are also implicated in cytoskeletal rearrangement, cell differentiation, transformation and proliferation. OSR1 and SPAK contain a conserved C-terminal (CCT) domain, which recognizes a unique motif ([RK]FX[VI]) present in their activating kinases (WNK1/WNK4) and their substrates. The OSR1 and SPAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270787 [Multi-domain]  Cd Length: 267  Bit Score: 113.22  E-value: 5.55e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQC-IERDEVRnvfRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDL----RYHLQQNVqFSEDTVR 77
Cdd:cd06610   30 AIKRIDLEKCqTSMDELR---KEIQAMSQCNHPNVVSYYTSFVVGDELWLVMPLLSGGSLldimKSSYPRGG-LDEAIIA 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  78 LYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNI-ATIIKDGERA----TALAGTKPYMAPEIFHSfvngG 152
Cdd:cd06610  106 TVLKEVLKGLEYLHSNGQIHRDVKAGNILLGEDGSVKIADFGVsASLATGGDRTrkvrKTFVGTPCWMAPEVMEQ----V 181
                        170       180
                 ....*....|....*....|....*.
gi 247269852 153 TGYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd06610  182 RGYDFKADIWSFGITAIELATGAAPY 207
STKc_Nek5 cd08225
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
23-225 8.60e-29

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Neks are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. The specific function of Nek5 is unknown. Nek5 is one in a family of 11 different Neks (Nek1-11). The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173765 [Multi-domain]  Cd Length: 257  Bit Score: 112.36  E-value: 8.60e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDL--RYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDV 100
Cdd:cd08225   48 KEVILLAKMKHPNIVTFFASFQENGRLFIVMEYCDGGDLmkRINRQRGVLFSEDQILSWFVQISLGLKHIHDRKILHRDI 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 101 KPDNILLDEQGH-AHLTDFNIATIIKDG-ERATALAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd08225  128 KSQNIFLSKNGMvAKLGDFGIARQLNDSmELAYTCVGTPYYLSPEICQN-----RPYNNKTDIWSLGCVLYELCTLKHPF 202
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 247269852 179 DihsSNAVESLV-----QLFSTVSvqyvPTWSKEMVALLRKLLTVNPEHRFS 225
Cdd:cd08225  203 E---GNNLHQLVlkicqGYFAPIS----PNFSRDLRSLISQLFKVSPRDRPS 247
STKc_MELK cd14078
Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase; ...
3-225 1.08e-28

Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MELK is a cell cycle dependent protein which functions in cytokinesis, cell cycle, apoptosis, cell proliferation, and mRNA processing. It is found upregulated in many types of cancer cells, playing an indispensable role in cancer cell survival. It makes an attractive target in the design of inhibitors for use in the treatment of a wide range of human cancer. The MELK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270980 [Multi-domain]  Cd Length: 257  Bit Score: 112.09  E-value: 1.08e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCieRDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICE 82
Cdd:cd14078   32 AIKIMDKKAL--GDDLPRVKTEIEALKNLSHQHICRLYHVIETDNKIFMVLEYCPGGELFDYIVAKDRLSEDEARVFFRQ 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDG--ERATALAGTKPYMAPEIfhsfVNGGTGYSFEVD 160
Cdd:cd14078  110 IVSAVAYVHSQGYAHRDLKPENLLLDEDQNLKLIDFGLCAKPKGGmdHHLETCCGSPAYAAPEL----IQGKPYIGSEAD 185
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 161 WWSVGVMAYELLRGWRPYDihsSNAVESLVQLFsTVSVQYVPTW-SKEMVALLRKLLTVNPEHRFS 225
Cdd:cd14078  186 VWSMGVLLYALLCGFLPFD---DDNVMALYRKI-QSGKYEEPEWlSPSSKLLLDQMLQVDPKKRIT 247
STKc_MST1_2 cd06612
Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2; ...
17-228 1.97e-28

Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MST1, MST2, and related proteins including Drosophila Hippo and Dictyostelium discoideum Krs1 (kinase responsive to stress 1). MST1/2 and Hippo are involved in a conserved pathway that governs cell contact inhibition, organ size control, and tumor development. MST1 activates the mitogen-activated protein kinases (MAPKs) p38 and c-Jun N-terminal kinase (JNK) through MKK7 and MEKK1 by acting as a MAPK kinase kinase kinase. Activation of JNK by MST1 leads to caspase activation and apoptosis. MST1 has also been implicated in cell proliferation and differentiation. Krs1 may regulate cell growth arrest and apoptosis in response to cellular stress. The MST1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132943 [Multi-domain]  Cd Length: 256  Bit Score: 111.20  E-value: 1.97e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  17 EVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQ-QNVQFSEDTVRLyICEMAL-ALDYLRSQH 94
Cdd:cd06612   41 DLQEIIKEISILKQCDSPYIVKYYGSYFKNTDLWIVMEYCGAGSVSDIMKiTNKTLTEEEIAA-ILYQTLkGLEYLHSNK 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  95 IIHRDVKPDNILLDEQGHAHLTDFNIATIIKD--GERATaLAGTKPYMAPEIFhsfvnGGTGYSFEVDWWSVGVMAYELL 172
Cdd:cd06612  120 KIHRDIKAGNILLNEEGQAKLADFGVSGQLTDtmAKRNT-VIGTPFWMAPEVI-----QEIGYNNKADIWSLGITAIEMA 193
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 247269852 173 RGWRPY-DIHSSNAveslvqLFsTVSVQYVPT------WSKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd06612  194 EGKPPYsDIHPMRA------IF-MIPNKPPPTlsdpekWSPEFNDFVKKCLVKDPEERPSAIQ 249
STKc_CaMKK1 cd14200
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; ...
21-225 2.57e-28

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). CaMKK1, also called CaMKK alpha, is involved in the regulation of glucose uptake in skeletal muscles, independently of AMPK and PKB activation. It also play roles in learning and memory. Studies on CaMKK1 knockout mice reveal deficits in fear conditioning. The CaMKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271102 [Multi-domain]  Cd Length: 284  Bit Score: 111.96  E-value: 2.57e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  21 VFRELEILQEIEHVFLVNLWYSFQD--EEDMFMVVDLLLGGDLrYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHR 98
Cdd:cd14200   70 VYQEIAILKKLDHVNIVKLIEVLDDpaEDNLYMVFDLLRKGPV-MEVPSDKPFSEDQARLYFRDIVLGIEYLHYQKIVHR 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  99 DVKPDNILLDEQGHAHLTDFNIATIIKDGE-RATALAGTKPYMAPEifhSFVNGGTGYSFE-VDWWSVGVMAYELLRGWR 176
Cdd:cd14200  149 DIKPSNLLLGDDGHVKIADFGVSNQFEGNDaLLSSTAGTPAFMAPE---TLSDSGQSFSGKaLDVWAMGVTLYCFVYGKC 225
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 247269852 177 PYdihssnAVESLVQLFSTVSVQYV-----PTWSKEMVALLRKLLTVNPEHRFS 225
Cdd:cd14200  226 PF------IDEFILALHNKIKNKPVefpeePEISEELKDLILKMLDKNPETRIT 273
PKc_MAPKK cd06605
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein Kinase ...
3-234 2.91e-28

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein Kinase Kinase; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MAPKKs are dual-specificity PKs that phosphorylate their downstream targets, MAPKs, at specific threonine and tyrosine residues. The MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The pathways involve a triple kinase core cascade comprising the MAPK, which is phosphorylated and activated by a MAPK kinase (MAPKK or MKK or MAP2K), which itself is phosphorylated and activated by a MAPKK kinase (MAPKKK or MKKK or MAP3K). There are three MAPK subfamilies: extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38. In mammalian cells, there are seven MAPKKs (named MKK1-7) and 20 MAPKKKs. Each MAPK subfamily can be activated by at least two cognate MAPKKs and by multiple MAPKKKs. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270782 [Multi-domain]  Cd Length: 265  Bit Score: 111.28  E-value: 2.91e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMnkQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICE 82
Cdd:cd06605   30 AVKVI--RLEIDEALQKQILRELDVLHKCNSPYIVGFYGAFYSEGDISICMEYMDGGSLDKILKEVGRIPERILGKIAVA 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQH-IIHRDVKPDNILLDEQGHAHLTDFNIATIIKDgERATALAGTKPYMAPEIFHsfvngGTGYSFEVDW 161
Cdd:cd06605  108 VVKGLIYLHEKHkIIHRDVKPSNILVNSRGQVKLCDFGVSGQLVD-SLAKTFVGTRSYMAPERIS-----GGKYTVKSDI 181
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 247269852 162 WSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVsVQYVP------TWSKEMVALLRKLLTVNPEHRfSSLQDMQTAP 234
Cdd:cd06605  182 WSLGLSLVELATGRFPYPPPNAKPSMMIFELLSYI-VDEPPpllpsgKFSPDFQDFVSQCLQKDPTER-PSYKELMEHP 258
STKc_CNK2-like cd08530
Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii CNK2 and similar ...
2-233 4.69e-28

Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii CNK2 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chlamydomonas reinhardtii CNK2 has both cilliary and cell cycle functions. It influences flagellar length through promoting flagellar disassembly, and it regulates cell size, through influencing the size threshold at which cells commit to mitosis. This subfamily belongs to the (NIMA)-related kinase (Nek) family, which includes seven different Chlamydomonas Neks (CNKs 1-6 and Fa2). This subfamily includes CNK1, and -2. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270869 [Multi-domain]  Cd Length: 256  Bit Score: 110.17  E-value: 4.69e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERdEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQ----FSEDTVR 77
Cdd:cd08530   28 YALKEVNLGSLSQK-EREDSVNEIRLLASVNHPNIIRYKEAFLDGNRLCIVMEYAPFGDLSKLISKRKKkrrlFPEDDIW 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  78 LYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALaGTKPYMAPEIFHsfvngGTGYSF 157
Cdd:cd08530  107 RIFIQMLRGLKALHDQKILHRDLKSANILLSAGDLVKIGDLGISKVLKKNLAKTQI-GTPLYAAPEVWK-----GRPYDY 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 158 EVDWWSVGVMAYELLRGWRPYdihssNAvESLVQLFSTVSVQYVP----TWSKEMVALLRKLLTVNPEHRFSSLQDMQTA 233
Cdd:cd08530  181 KSDIWSLGCLLYEMATFRPPF-----EA-RTMQELRYKVCRGKFPpippVYSQDLQQIIRSLLQVNPKKRPSCDKLLQSP 254
STKc_SIK cd14071
Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases; STKs catalyze the ...
3-225 7.71e-28

Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SIKs are part of a complex network that regulates Na,K-ATPase to maintain sodium homeostasis and blood pressure. Vertebrates contain three forms of SIKs (SIK1-3) from three distinct genes, which display tissue-specific effects. SIK1, also called SNF1LK, controls steroidogenic enzyme production in adrenocortical cells. In the brain, both SIK1 and SIK2 regulate energy metabolism. SIK2, also called QIK or SNF1LK2, is involved in the regulation of gluconeogenesis in the liver and lipogenesis in adipose tissues, where it phosphorylates the insulin receptor substrate-1. In the liver, SIK3 (also called QSK) regulates cholesterol and bile acid metabolism. In addition, SIK2 plays an important role in the initiation of mitosis and regulates the localization of C-Nap1, a centrosome linker protein. The SIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270973 [Multi-domain]  Cd Length: 253  Bit Score: 109.79  E-value: 7.71e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQcIERDEVRNVFRELEILQEIEHVFLVNLwYSFQDEEDM-FMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd14071   29 AIKIIDKSQ-LDEENLKKIYREVQIMKMLNHPHIIKL-YQVMETKDMlYLVTEYASNGEIFDYLAQHGRMSEKEARKKFW 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSF-EVD 160
Cdd:cd14071  107 QILSAVEYCHKRHIVHRDLKAENLLLDANMNIKIADFGFSNFFKPGELLKTWCGSPPYAAPEVFE-----GKEYEGpQLD 181
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 161 WWSVGVMAYELLRGWRPYDIHSSNAVESLVqlfstVSVQY-VPTW-SKEMVALLRKLLTVNPEHRFS 225
Cdd:cd14071  182 IWSLGVVLYVLVCGALPFDGSTLQTLRDRV-----LSGRFrIPFFmSTDCEHLIRRMLVLDPSKRLT 243
STKc_FA2-like cd08529
Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii FA2 and similar ...
2-236 1.07e-27

Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii FA2 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chlamydomonas reinhardtii FA2 was discovered in a genetic screen for deflagellation-defective mutants. It is essential for basal-body/centriole-associated microtubule severing, and plays a role in cell cycle progression. No cellular function has yet been ascribed to CNK4. The Chlamydomonas reinhardtii FA2-like subfamily belongs to the (NIMA)-related kinase (Nek) family, which includes seven different Chlamydomonas Neks (CNKs 1-6 and Fa2). This subfamily contains FA2 and CNK4. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270868 [Multi-domain]  Cd Length: 256  Bit Score: 109.42  E-value: 1.07e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQcIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLR--YHLQQNVQFSEDTVRLY 79
Cdd:cd08529   28 YALKQIDISR-MSRKMREEAIDEARVLSKLNSPYVIKYYDSFVDKGKLNIVMEYAENGDLHslIKSQRGRPLPEDQIWKF 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKD-GERATALAGTKPYMAPEIFHsfvngGTGYSFE 158
Cdd:cd08529  107 FIQTLLGLSHLHSKKILHRDIKSMNIFLDKGDNVKIGDLGVAKILSDtTNFAQTIVGTPYYLSPELCE-----DKPYNEK 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDIHSSNA-VESLVQ-LFSTVSVQYvptwSKEMVALLRKLLTVNPEHRFSSLQDMQTaPSL 236
Cdd:cd08529  182 SDVWALGCVLYELCTGKHPFEAQNQGAlILKIVRgKYPPISASY----SQDLSQLIDSCLTKDYRQRPDTTELLRN-PSL 256
STKc_CAMKK cd14118
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase; ...
2-223 1.26e-27

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). Vertebrates contain two CaMKKs, CaMKK1 (or alpha) and CaMKK2 (or beta). CaMKK1 is involved in the regulation of glucose uptake in skeletal muscles. CaMKK2 is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. The CaMKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271020 [Multi-domain]  Cd Length: 275  Bit Score: 109.76  E-value: 1.26e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIER--------------------DEVRNVFRELEILQEIEHVFLVNLWYSFQD--EEDMFMVVDLLLGG 59
Cdd:cd14118   22 YAMKILSKKKLLKQagffrrppprrkpgalgkplDPLDRVYREIAILKKLDHPNVVKLVEVLDDpnEDNLYMVFELVDKG 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  60 DLrYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE-RATALAGTKP 138
Cdd:cd14118  102 AV-MEVPTDNPLSEETARSYFRDIVLGIEYLHYQKIIHRDIKPSNLLLGDDGHVKIADFGVSNEFEGDDaLLSSTAGTPA 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 139 YMAPEifhSFVNGGTGYSFE-VDWWSVGVMAYELLRGWRPYdihSSNAVESLVQLFSTVSVQY--VPTWSKEMVALLRKL 215
Cdd:cd14118  181 FMAPE---ALSESRKKFSGKaLDIWAMGVTLYCFVFGRCPF---EDDHILGLHEKIKTDPVVFpdDPVVSEQLKDLILRM 254

                 ....*...
gi 247269852 216 LTVNPEHR 223
Cdd:cd14118  255 LDKNPSER 262
STKc_ULK4 cd14010
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4; STKs catalyze the ...
2-225 1.47e-27

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ULK4 is a functionally uncharacterized kinase that shows similarity to ATG1/ULKs. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. The ULK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270912 [Multi-domain]  Cd Length: 269  Bit Score: 109.31  E-value: 1.47e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQcieRDEVRNVFReleILQEIEHVFLVNL--WYSFQDEedMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLY 79
Cdd:cd14010   28 VAIKCVDKSK---RPEVLNEVR---LTHELKHPNVLKFyeWYETSNH--LWLVVEYCTGGDLETLLRQDGNLPESSVRKF 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIA-----------------TIIKDGERATALAGTKPYMAP 142
Cdd:cd14010  100 GRDLVRGLHYIHSKGIIYCDLKPSNILLDGNGTLKLSDFGLArregeilkelfgqfsdeGNVNKVSKKQAKRGTPYYMAP 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 143 EIFHSFVnggtgYSFEVDWWSVGVMAYELLRGWRPYdihSSNAVESLVQL-----FSTVSVQYVPTWSKEMVALLRKLLT 217
Cdd:cd14010  180 ELFQGGV-----HSFASDLWALGCVLYEMFTGKPPF---VAESFTELVEKilnedPPPPPPKVSSKPSPDFKSLLKGLLE 251

                 ....*...
gi 247269852 218 VNPEHRFS 225
Cdd:cd14010  252 KDPAKRLS 259
STKc_RCK1-like cd14096
Catalytic domain of RCK1-like Serine/Threonine Kinases; STKs catalyze the transfer of the ...
3-224 2.40e-27

Catalytic domain of RCK1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of fungal STKs including Saccharomyces cerevisiae RCK1 and RCK2, Schizosaccharomyces pombe Sty1-regulated kinase 1 (Srk1), and similar proteins. RCK1, RCK2 (or Rck2p), and Srk1 are MAPK-activated protein kinases. RCK1 and RCK2 are involved in oxidative and metal stress resistance in budding yeast. RCK2 also regulates rapamycin sensitivity in both S. cerevisiae and Candida albicans. Srk1 is activated by Sty1/Spc1 and is involved in negatively regulating cell cycle progression by inhibiting Cdc25. The RCK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270998 [Multi-domain]  Cd Length: 295  Bit Score: 109.45  E-value: 2.40e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQ----CIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRL 78
Cdd:cd14096   31 AIKVVRKADlssdNLKGSSRANILKEVQIMKRLSHPNIVKLLDFQESDEYYYIVLELADGGEIFHQIVRLTYFSEDLSRH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNIL----------------------LDEQ-----------GHAHLTDFNIATIIK 125
Cdd:cd14096  111 VITQVASAVKYLHEIGVVHRDIKPENLLfepipfipsivklrkadddetkVDEGefipgvggggiGIVKLADFGLSKQVW 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 126 DGERATAlAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELLRGWRP-YDihssnavESLVQLFSTVSV-QYV-- 201
Cdd:cd14096  191 DSNTKTP-CGTVGYTAPEVVKD-----ERYSKKVDMWALGCVLYTLLCGFPPfYD-------ESIETLTEKISRgDYTfl 257
                        250       260
                 ....*....|....*....|....*..
gi 247269852 202 -PTW---SKEMVALLRKLLTVNPEHRF 224
Cdd:cd14096  258 sPWWdeiSKSAKDLISHLLTVDPAKRY 284
STKc_ULK2 cd14201
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2; STKs catalyze the ...
3-216 3.59e-27

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK2 is ubiquitously expressed and is essential in autophagy induction. It displays partially redundant functions with ULK1 and is able to compensate for the loss of ULK1 in non-selective autophagy. It also displays neuron-specific functions and is important in axon development. The ULK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271103 [Multi-domain]  Cd Length: 271  Bit Score: 108.56  E-value: 3.59e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQcIERDEVRnVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICE 82
Cdd:cd14201   36 AIKSINKKN-LSKSQIL-LGKEIKILKELQHENIVALYDVQEMPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLQQ 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQHIIHRDVKPDNILLDEQGHA---------HLTDFNIATIIKDGERATALAGTKPYMAPEIFHSfvnggT 153
Cdd:cd14201  114 IAAAMRILHSKGIIHRDLKPQNILLSYASRKkssvsgiriKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMS-----Q 188
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 247269852 154 GYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAveslVQLFSTVSVQYVPTWSKEMVALLRKLL 216
Cdd:cd14201  189 HYDAKADLWSIGTVIYQCLVGKPPFQANSPQD----LRMFYEKNKNLQPSIPRETSPYLADLL 247
STKc_Bck1_like cd06629
Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein ...
24-223 5.61e-27

Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein Kinase Kinase Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include the MAPKKKs Saccharomyces cerevisiae Bck1 and Schizosaccharomyces pombe Mkh1, and related proteins. Budding yeast Bck1 is part of the cell integrity MAPK pathway, which is activated by stresses and aggressions to the cell wall. The MAPKKK Bck1, MAPKKs Mkk1 and Mkk2, and the MAPK Slt2 make up the cascade that is important in the maintenance of cell wall homeostasis. Fission yeast Mkh1 is involved in MAPK cascades regulating cell morphology, cell wall integrity, salt resistance, and filamentous growth in response to stress. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The Bck1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270799 [Multi-domain]  Cd Length: 270  Bit Score: 107.85  E-value: 5.61e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  24 ELEILQEIEHVFLVNlWYSFQDEEDMFMV-VDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKP 102
Cdd:cd06629   58 EIDTLKDLDHPNIVQ-YLGFEETEDYFSIfLEYVPGGSIGSCLRKYGKFEEDLVRFFTRQILDGLAYLHSKGILHRDLKA 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 103 DNILLDEQGHAHLTDFNI---ATIIKDGERATALAGTKPYMAPEIFHSFvngGTGYSFEVDWWSVGVMAYELLRGWRPYD 179
Cdd:cd06629  137 DNILVDLEGICKISDFGIskkSDDIYGNNGATSMQGSVFWMAPEVIHSQ---GQGYSAKVDIWSLGCVVLEMLAGRRPWS 213
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 247269852 180 ihSSNAVESLVQLFSTVSVQYVP---TWSKEMVALLRKLLTVNPEHR 223
Cdd:cd06629  214 --DDEAIAAMFKLGNKRSAPPVPedvNLSPEALDFLNACFAIDPRDR 258
STKc_LKB1 cd14119
Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1; STKs catalyze the transfer ...
20-231 6.63e-27

Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LKB1, also called STK11, was first identified as a tumor suppressor responsible for Peutz-Jeghers syndrome, a disorder that leads to an increased risk of spontaneous epithelial cancer. It serves as a master upstream kinase that activates AMP-activated protein kinase (AMPK) and most AMPK-like kinases. LKB1 and AMPK are part of an energy-sensing pathway that links cell energy to metabolism and cell growth. They play critical roles in the establishment and maintenance of cell polarity, cell proliferation, cytoskeletal organization, as well as T-cell metabolism, including T-cell development, homeostasis, and effector function. To be activated, LKB1 requires the adaptor proteins STe20-Related ADaptor (STRAD) and mouse protein 25 (MO25). The LKB1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271021 [Multi-domain]  Cd Length: 255  Bit Score: 107.34  E-value: 6.63e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  20 NVFRELEILQEIEHVFLVNLWYSFQDEED--MFMVVDLLLGGdlryhLQQNVQFSEDTvRL-------YICEMALALDYL 90
Cdd:cd14119   40 NVKREIQILRRLNHRNVIKLVDVLYNEEKqkLYMVMEYCVGG-----LQEMLDSAPDK-RLpiwqahgYFVQLIDGLEYL 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  91 RSQHIIHRDVKPDNILLDEQGHAHLTDFNIA---TIIKDGERATALAGTKPYMAPEIfhsfVNGGTGYS-FEVDWWSVGV 166
Cdd:cd14119  114 HSQGIIHKDIKPGNLLLTTDGTLKISDFGVAealDLFAEDDTCTTSQGSPAFQPPEI----ANGQDSFSgFKVDIWSAGV 189
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 167 MAYELLRGWRPYDihssnaVESLVQLFSTVSV-QY-VPTW-SKEMVALLRKLLTVNPEHRFsSLQDMQ 231
Cdd:cd14119  190 TLYNMTTGKYPFE------GDNIYKLFENIGKgEYtIPDDvDPDLQDLLRGMLEKDPEKRF-TIEQIR 250
STKc_Nek10 cd08528
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
1-223 9.70e-27

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. No function has yet been ascribed to Nek10. The gene encoding Nek10 is a putative causative gene for breast cancer; it is located within a breast cancer susceptibility loci on chromosome 3p24. Nek10 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270867 [Multi-domain]  Cd Length: 270  Bit Score: 107.20  E-value: 9.70e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCI------ERDE-VRNVFRELEIL-QEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL----QQN 68
Cdd:cd08528   28 LLALKEINMTNPAfgrteqERDKsVGDIISEVNIIkEQLRHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFsslkEKN 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  69 VQFSEDTVRLYICEMALALDYL-RSQHIIHRDVKPDNILLDEQGHAHLTDFNIA-TIIKDGERATALAGTKPYMAPEIFH 146
Cdd:cd08528  108 EHFTEDRIWNIFVQMVLALRYLhKEKQIVHRDLKPNNIMLGEDDKVTITDFGLAkQKGPESSKMTSVVGTILYSCPEIVQ 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 147 SFvnggtGYSFEVDWWSVGVMAYELLRGWRPYdiHSSNAVESLVQLfstVSVQYVP----TWSKEMVALLRKLLTVNPEH 222
Cdd:cd08528  188 NE-----PYGEKADIWALGCILYQMCTLQPPF--YSTNMLTLATKI---VEAEYEPlpegMYSDDITFVIRSCLTPDPEA 257

                 .
gi 247269852 223 R 223
Cdd:cd08528  258 R 258
STKc_DAPK2 cd14196
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2; STKs ...
2-178 1.36e-26

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK2, also called DAPK-related protein 1 (DRP-1), is a Ca2+/calmodulin (CaM)-regulated protein containing an N-terminal kinase domain, a CaM autoinhibitory site and a dimerization module. It lacks the cytoskeletal binding regions of DAPK1 and the exogenous protein has been shown to be soluble and cytoplasmic. FLAG-tagged DAPK2, however, accumulated within membrane-enclosed autophagic vesicles. It is unclear where endogenous DAPK2 is localized. DAPK2 participates in TNF-alpha and FAS-receptor induced cell death and enhances neutrophilic maturation in myeloid leukemic cells. It contributes to the induction of anoikis and its down-regulation is implicated in the beta-catenin induced resistance of malignant epithelial cells to anoikis. The DAPK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271098 [Multi-domain]  Cd Length: 269  Bit Score: 106.58  E-value: 1.36e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQC------IERDEVRnvfRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDT 75
Cdd:cd14196   33 YAAKFIKKRQSrasrrgVSREEIE---REVSILRQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEE 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  76 VRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQG----HAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSFVNG 151
Cdd:cd14196  110 ATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNipipHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLG 189
                        170       180
                 ....*....|....*....|....*..
gi 247269852 152 gtgysFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd14196  190 -----LEADMWSIGVITYILLSGASPF 211
STKc_Nek2 cd08217
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
24-228 1.36e-26

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Nek2 subfamily includes Aspergillus nidulans NIMA kinase, the founding member of the Nek family, which was identified in a screen for cell cycle mutants prevented from entering mitosis. NIMA is essential for mitotic entry and progression through mitosis, and its degradation is essential for mitotic exit. NIMA is involved in nuclear membrane fission. Vertebrate Nek2 is a cell cycle-regulated STK, localized in centrosomes and kinetochores, that regulates centrosome splitting at the G2/M phase. It also interacts with other mitotic kinases such as Polo-like kinase 1 and may play a role in spindle checkpoint. An increase in the expression of the human NEK2 gene is strongly associated with the progression of non-Hodgkin lymphoma. Nek2 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. It The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270857 [Multi-domain]  Cd Length: 265  Bit Score: 106.47  E-value: 1.36e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  24 ELEILQEIEHVFLVNLWYSFQDEE--DMFMVVDLLLGGDL----RYHLQQNVQFSEDTVRLYICEMALALDY-----LRS 92
Cdd:cd08217   49 EVNILRELKHPNIVRYYDRIVDRAntTLYIVMEYCEGGDLaqliKKCKKENQYIPEEFIWKIFTQLLLALYEchnrsVGG 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDG-ERATALAGTKPYMAPEIfhsfVNGGTgYSFEVDWWSVGVMAYEL 171
Cdd:cd08217  129 GKILHRDLKPANIFLDSDNNVKLGDFGLARVLSHDsSFAKTYVGTPYYMSPEL----LNEQS-YDEKSDIWSLGCLIYEL 203
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 247269852 172 LRGWRPYDIHSSNAVESLVQ--LFSTVSVQYvptwSKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd08217  204 CALHPPFQAANQLELAKKIKegKFPRIPSRY----SSELNEVIKSMLNVDPDKRPSVEE 258
STKc_MEKK1_plant cd06632
Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP) ...
1-223 1.40e-26

Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of plant MAPK kinase kinases (MAPKKKs) including Arabidopsis thaliana MEKK1 and MAPKKK3. Arabidopsis thaliana MEKK1 activates MPK4, a MAPK that regulates systemic acquired resistance. MEKK1 also participates in the regulation of temperature-sensitive and tissue-specific cell death. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The plant MEKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270802 [Multi-domain]  Cd Length: 259  Bit Score: 106.33  E-value: 1.40e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMN-------KQQCIERDEvrnvfRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSE 73
Cdd:cd06632   27 FFAVKEVSlvdddkkSRESVKQLE-----QEIALLSKLRHPNIVQYYGTEREEDNLYIFLEYVPGGSIHKLLQRYGAFEE 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  74 DTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSFvngGT 153
Cdd:cd06632  102 PVIRLYTRQILSGLAYLHSRNTVHRDIKGANILVDTNGVVKLADFGMAKHVEAFSFAKSFKGSPYWMAPEVIMQK---NS 178
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 247269852 154 GYSFEVDWWSVGVMAYELLRGWRPYdiHSSNAVESLVQLFSTVSVQYVP-TWSKEMVALLRKLLTVNPEHR 223
Cdd:cd06632  179 GYGLAVDIWSLGCTVLEMATGKPPW--SQYEGVAAIFKIGNSGELPPIPdHLSPDAKDFIRLCLQRDPEDR 247
STKc_DCKL1 cd14183
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called ...
2-231 1.56e-26

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL1 (or DCAMKL1) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL1 contains a serine, threonine, and proline rich domain (SP) and a C-terminal kinase domain with similarity to CAMKs. DCKL1 interacts with tubulin, glucocorticoid receptor, dynein, JIP1/2, caspases (3 and 8), and calpain, among others. It plays roles in neurogenesis, neuronal migration, retrograde transport, and neuronal apoptosis. The DCKL1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271085 [Multi-domain]  Cd Length: 268  Bit Score: 106.62  E-value: 1.56e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCieRDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd14183   34 YALKIINKSKC--RGKEHMIQNEVSILRRVKHPNIVLLIEEMDMPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLY 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILL----DEQGHAHLTDFNIATIIkDGERATaLAGTKPYMAPEIFHSfvnggTGYSF 157
Cdd:cd14183  112 NLASAIKYLHSLNIVHRDIKPENLLVyehqDGSKSLKLGDFGLATVV-DGPLYT-VCGTPTYVAPEIIAE-----TGYGL 184
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 158 EVDWWSVGVMAYELLRGWRPYDiHSSNAVESLVQLFSTVSVQY-VPTW---SKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd14183  185 KVDIWAAGVITYILLCGFPPFR-GSGDDQEVLFDQILMGQVDFpSPYWdnvSDSAKELITMMLQVDVDQRYSALQVLE 261
STKc_MARK cd14072
Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases; ...
3-231 1.96e-26

Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MARKs, also called Partitioning-defective 1 (Par1) proteins, function as regulators of diverse cellular processes in nematodes, Drosophila, yeast, and vertebrates. They are involved in embryogenesis, epithelial cell polarization, cell signaling, and neuronal differentiation. MARKs phosphorylate tau and related microtubule-associated proteins (MAPs), and regulates microtubule-based intracellular transport. Vertebrates contain four isoforms, namely MARK1 (or Par1c), MARK2 (or Par1b), MARK3 (Par1a), and MARK4 (or MARKL1). Known substrates of MARKs include the cell cycle-regulating phosphatase Cdc25, tyrosine phosphatase PTPH1, MAPK scaffolding protein KSR1, class IIa histone deacetylases, and plakophilin 2. The MARK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270974 [Multi-domain]  Cd Length: 253  Bit Score: 106.06  E-value: 1.96e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQcIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICE 82
Cdd:cd14072   29 AIKIIDKTQ-LNPSSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQ 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSF-EVDW 161
Cdd:cd14072  108 IVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTPGNKLDTFCGSPPYAAPELFQ-----GKKYDGpEVDV 182
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 247269852 162 WSVGVMAYELLRGWRPYDIHSSNAVESLVqlfstVSVQY-VPTW-SKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd14072  183 WSLGVILYTLVSGSLPFDGQNLKELRERV-----LRGKYrIPFYmSTDCENLLKKFLVLNPSKRGTLEQIMK 249
STKc_Nek1 cd08218
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
7-225 2.80e-26

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek1 is associated with centrosomes throughout the cell cycle. It is involved in the formation of primary cilium and in the maintenance of centrosomes. It cycles through the nucleus and may be capable of relaying signals between the cilium and the nucleus. Nek1 is implicated in the development of polycystic kidney disease, which is characterized by benign polycystic tumors formed by abnormal overgrowth of renal epithelial cells. It appears also to be involved in DNA damage response, and may be important for both correct DNA damage checkpoint activation and DNA repair. Nek1 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270858 [Multi-domain]  Cd Length: 256  Bit Score: 105.66  E-value: 2.80e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   7 MNKQQCIERDEVRnvfRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDL--RYHLQQNVQFSEDTVRLYICEMA 84
Cdd:cd08218   35 ISKMSPKEREESR---KEVAVLSKMKHPNIVQYQESFEENGNLYIVMDYCDGGDLykRINAQRGVLFPEDQILDWFVQLC 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  85 LALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKD-GERATALAGTKPYMAPEIFHSfvnggTGYSFEVDWWS 163
Cdd:cd08218  112 LALKHVHDRKILHRDIKSQNIFLTKDGIIKLGDFGIARVLNStVELARTCIGTPYYLSPEICEN-----KPYNNKSDIWA 186
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 247269852 164 VGVMAYELLRGWRPYDIHS-SNAVESLVQ-LFSTVSVQYvptwSKEMVALLRKLLTVNPEHRFS 225
Cdd:cd08218  187 LGCVLYEMCTLKHAFEAGNmKNLVLKIIRgSYPPVPSRY----SYDLRSLVSQLFKRNPRDRPS 246
STKc_CaMKI_alpha cd14167
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
24-231 2.82e-26

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271069 [Multi-domain]  Cd Length: 263  Bit Score: 105.88  E-value: 2.82e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  24 ELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKPD 103
Cdd:cd14167   51 EIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASKLIFQILDAVKYLHDMGIVHRDLKPE 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 104 NIL---LDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFhsfvnGGTGYSFEVDWWSVGVMAYELLRGWRP-YD 179
Cdd:cd14167  131 NLLyysLDEDSKIMISDFGLSKIEGSGSVMSTACGTPGYVAPEVL-----AQKPYSKAVDCWSIGVIAYILLCGYPPfYD 205
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 247269852 180 IHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd14167  206 ENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIQHLMEKDPEKRFTCEQALQ 257
STKc_MLCK cd14103
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase; STKs catalyze the ...
2-231 4.73e-26

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. In vertebrates, different MLCKs function in smooth (MLCK1), skeletal (MLCK2), and cardiac (MLCK3) muscles. A fourth protein, MLCK4, has also been identified through comprehensive genome analysis although it has not been biochemically characterized. The MLCK1 gene expresses three transcripts in a cell-specific manner: a short MLCK1 which contains three immunoglobulin (Ig)-like and one fibronectin type III (FN3) domains, PEVK and actin-binding regions, and a kinase domain near the C-terminus; a long MLCK1 containing six additional Ig-like domains at the N-terminus compared to the short MLCK1; and the C-terminal Ig module. MLCK2, MLCK3, and MLCK4 share a simpler domain architecture of a single kinase domain near the C-terminus and the absence of Ig-like or FN3 domains. The MLCK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271005 [Multi-domain]  Cd Length: 250  Bit Score: 104.62  E-value: 4.73e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNvfrELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDL-------RYHLqqnvqfSED 74
Cdd:cd14103   21 LAAKFIKCRKAKDREDVRN---EIEIMNQLRHPRLLQLYDAFETPREMVLVMEYVAGGELfervvddDFEL------TER 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  75 TVRLYICEMALALDYLRSQHIIHRDVKPDNIL-LDEQGHA-HLTDFNIATIIKDGERATALAGTKPYMAPEIfhsfVNgg 152
Cdd:cd14103   92 DCILFMRQICEGVQYMHKQGILHLDLKPENILcVSRTGNQiKIIDFGLARKYDPDKKLKVLFGTPEFVAPEV----VN-- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 153 tgY---SFEVDWWSVGVMAYELLRGWRPY----DIHSSNAVESLVQLFSTVSVQYVPTWSKEMVAllrKLLTVNPEHRFS 225
Cdd:cd14103  166 --YepiSYATDMWSVGVICYVLLSGLSPFmgdnDAETLANVTRAKWDFDDEAFDDISDEAKDFIS---KLLVKDPRKRMS 240

                 ....*.
gi 247269852 226 SLQDMQ 231
Cdd:cd14103  241 AAQCLQ 246
STKc_CaMKI_gamma cd14166
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
1-231 5.43e-26

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I gamma; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-gamma subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271068 [Multi-domain]  Cd Length: 285  Bit Score: 105.46  E-value: 5.43e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNvfrELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14166   30 LYALKCIKKSPLSRDSSLEN---EIAVLKRIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASRVI 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILL---DEQGHAHLTDFNIATIIKDGERATAlAGTKPYMAPEIFhsfvnGGTGYSF 157
Cdd:cd14166  107 NQVLSAVKYLHENGIVHRDLKPENLLYltpDENSKIMITDFGLSKMEQNGIMSTA-CGTPGYVAPEVL-----AQKPYSK 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 158 EVDWWSVGVMAYELLRGWRPYdihssnAVESLVQLFSTVSVQYV----PTW---SKEMVALLRKLLTVNPEHRFSSLQDM 230
Cdd:cd14166  181 AVDCWSIGVITYILLCGYPPF------YEETESRLFEKIKEGYYefesPFWddiSESAKDFIRHLLEKNPSKRYTCEKAL 254

                 .
gi 247269852 231 Q 231
Cdd:cd14166  255 S 255
STKc_CaMKI cd14083
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
1-231 7.02e-26

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270985 [Multi-domain]  Cd Length: 259  Bit Score: 104.38  E-value: 7.02e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKymnkqqCIERDEVR----NVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTV 76
Cdd:cd14083   30 LVAIK------CIDKKALKgkedSLENEIAVLRKIKHPNIVQLLDIYESKSHLYLVMELVTGGELFDRIVEKGSYTEKDA 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  77 RLYICEMALALDYLRSQHIIHRDVKPDNIL---LDEQGHAHLTDFNIATIIKDGERATAlAGTKPYMAPEIFHSfvnggT 153
Cdd:cd14083  104 SHLIRQVLEAVDYLHSLGIVHRDLKPENLLyysPDEDSKIMISDFGLSKMEDSGVMSTA-CGTPGYVAPEVLAQ-----K 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 154 GYSFEVDWWSVGVMAYELLRGWRP-YDihssnavESLVQLFSTV-SVQY---VPTW---SKEMVALLRKLLTVNPEHRFS 225
Cdd:cd14083  178 PYGKAVDCWSIGVISYILLCGYPPfYD-------ENDSKLFAQIlKAEYefdSPYWddiSDSAKDFIRHLMEKDPNKRYT 250

                 ....*.
gi 247269852 226 SLQDMQ 231
Cdd:cd14083  251 CEQALE 256
STKc_Aurora-B_like cd14117
Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins; STKs ...
3-231 8.82e-26

Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). This subfamily includes Aurora-B and Aurora-C. Aurora-B is most active at the transition during metaphase to the end of mitosis. It associates with centromeres, relocates to the midzone of the central spindle, and concentrates at the midbody during cell division. It is critical for accurate chromosomal segregation, cytokinesis, protein localization to the centrosome and kinetochore, correct microtubule-kinetochore attachments, and regulation of the mitotic checkpoint. Aurora-C is mainly expressed in meiotically dividing cells; it was originally discovered in mice as a testis-specific STK called Aie1. Both Aurora-B and -C are chromosomal passenger proteins that can form complexes with INCENP and survivin, and they may have redundant cellular functions. INCENP participates in the activation of Aurora-B in a two-step process: first by binding to form an intermediate state of activation and the phosphorylation of its C-terminal TSS motif to generate the fully active kinase. The Aurora-B subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271019 [Multi-domain]  Cd Length: 270  Bit Score: 104.56  E-value: 8.82e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQcIERDEVRNVFR-ELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd14117   35 ALKVLFKSQ-IEKEGVEHQLRrEIEIQSHLRHPNILRLYNYFHDRKRIYLILEYAPRGELYKELQKHGRFDEQRTATFME 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATaLAGTKPYMAPEIFHsfvngGTGYSFEVDW 161
Cdd:cd14117  114 ELADALHYCHEKKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRT-MCGTLDYLPPEMIE-----GRTHDEKVDL 187
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 162 WSVGVMAYELLRGWRPYDIHSSNAVESLVqlfSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd14117  188 WCIGVLCYELLVGMPPFESASHTETYRRI---VKVDLKFPPFLSDGSRDLISKLLRYHPSERLPLKGVME 254
STKc_DAPK1 cd14194
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1; STKs ...
2-231 1.36e-25

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK1 is the prototypical member of the subfamily and is also simply referred to as DAPK. It is Ca2+/calmodulin (CaM)-regulated and actin-associated protein that contains an N-terminal kinase domain followed by an autoinhibitory CaM binding region and a large C-terminal extension with multiple functional domains including ankyrin (ANK) repeats, a cytoskeletal binding domain, a Death domain, and a serine-rich tail. Loss of DAPK1 expression, usually because of DNA methylation, is implicated in many tumor types. DAPK1 is highly abundant in the brain and has also been associated with neurodegeneration. The DAPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271096 [Multi-domain]  Cd Length: 269  Bit Score: 103.95  E-value: 1.36e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQC------IERDEVRnvfRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDT 75
Cdd:cd14194   33 YAAKFIKKRRTkssrrgVSREDIE---REVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEE 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  76 VRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAH----LTDFNIATIIKDGERATALAGTKPYMAPEIFHSFVNG 151
Cdd:cd14194  110 ATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKprikIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLG 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 152 gtgysFEVDWWSVGVMAYELLRGWRPYdiHSSNAVESLVQLfSTVSVQYVPTWSKEMVAL----LRKLLTVNPEHRFSSL 227
Cdd:cd14194  190 -----LEADMWSIGVITYILLSGASPF--LGDTKQETLANV-SAVNYEFEDEYFSNTSALakdfIRRLLVKDPKKRMTIQ 261

                 ....
gi 247269852 228 QDMQ 231
Cdd:cd14194  262 DSLQ 265
STKc_Cdc7_like cd06627
Catalytic domain of Cell division control protein 7-like Serine/Threonine Kinases; STKs ...
13-226 1.48e-25

Catalytic domain of Cell division control protein 7-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily include Schizosaccharomyces pombe Cdc7, Saccharomyces cerevisiae Cdc15, Arabidopsis thaliana mitogen-activated protein kinase kinase kinase (MAPKKK) epsilon, and related proteins. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Fission yeast Cdc7 is essential for cell division by playing a key role in the initiation of septum formation and cytokinesis. Budding yeast Cdc15 functions to coordinate mitotic exit with cytokinesis. Arabidopsis MAPKKK epsilon is required for pollen development in the plasma membrane. The Cdc7-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270797 [Multi-domain]  Cd Length: 254  Bit Score: 103.46  E-value: 1.48e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  13 IERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRS 92
Cdd:cd06627   38 IPKSDLKSVMGEIDLLKKLNHPNIVKYIGSVKTKDSLYIILEYVENGSLASIIKKFGKFPESLVAVYIYQVLEGLAYLHE 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKD-GERATALAGTkPY-MAPEIFHsfvngGTGYSFEVDWWSVGVMAYE 170
Cdd:cd06627  118 QGVIHRDIKGANILTTKDGLVKLADFGVATKLNEvEKDENSVVGT-PYwMAPEVIE-----MSGVTTASDIWSVGCTVIE 191
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 171 LLRGWRPY-DIHSSNAveslvqLFSTVSVQYVP---TWSKEMVALLRKLLTVNPEHRFSS 226
Cdd:cd06627  192 LLTGNPPYyDLQPMAA------LFRIVQDDHPPlpeNISPELRDFLLQCFQKDPTLRPSA 245
STKc_Mnk1 cd14174
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase ...
2-178 2.08e-25

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271076 [Multi-domain]  Cd Length: 289  Bit Score: 103.96  E-value: 2.08e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVrnvFRELEILQEIE-HVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14174   30 YAVKIIEKNAGHSRSRV---FREVETLYQCQgNKNILELIEFFEDDTRFYLVFEKLRGGSILAHIQKRKHFNEREASRVV 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILL---DEQGHAHLTDFNIATIIKDGERATALA--------GTKPYMAPEIFHSFV 149
Cdd:cd14174  107 RDIASALDFLHTKGIAHRDLKPENILCespDKVSPVKICDFDLGSGVKLNSACTPITtpelttpcGSAEYMAPEVVEVFT 186
                        170       180
                 ....*....|....*....|....*....
gi 247269852 150 NGGTGYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd14174  187 DEATFYDKRCDLWSLGVILYIMLSGYPPF 215
STKc_CMGC cd05118
Catalytic domain of CMGC family Serine/Threonine Kinases; STKs catalyze the transfer of the ...
23-231 2.81e-25

Catalytic domain of CMGC family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CMGC family consists of Cyclin-Dependent protein Kinases (CDKs), Mitogen-activated protein kinases (MAPKs) such as Extracellular signal-regulated kinase (ERKs), c-Jun N-terminal kinases (JNKs), and p38, and other kinases. CDKs belong to a large subfamily of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation, proliferation, migration, and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer, stroke, diabetes, and chronic inflammation. Other members of the CMGC family include casein kinase 2 (CK2), Dual-specificity tYrosine-phosphorylated and -Regulated Kinase (DYRK), Glycogen Synthase Kinase 3 (GSK3), among many others. The CMGC family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270688 [Multi-domain]  Cd Length: 249  Bit Score: 102.70  E-value: 2.81e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIE----HVFLVNLWYSFQDEE--DMFMVVDLLlGGDLRYHLQQNVQ-FSEDTVRLYICEMALALDYLRSQHI 95
Cdd:cd05118   44 REIKLLKHLNdvegHPNIVKLLDVFEHRGgnHLCLVFELM-GMNLYELIKDYPRgLPLDLIKSYLYQLLQALDFLHSNGI 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  96 IHRDVKPDNILLDEQGHA-HLTDFNIATIIKDGErATALAGTKPYMAPEIfhsfVNGGTGYSFEVDWWSVGVMAYELLRG 174
Cdd:cd05118  123 IHRDLKPENILINLELGQlKLADFGLARSFTSPP-YTPYVATRWYRAPEV----LLGAKPYGSSIDIWSLGCILAELLTG 197
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 175 WRPYDIHSsnaveSLVQLFSTVSVqyvpTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd05118  198 RPLFPGDS-----EVDQLAKIVRL----LGTPEALDLLSKMLKYDPAKRITASQALA 245
STKc_HUNK cd14070
Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase ...
3-231 3.88e-25

Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase (also called MAK-V); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HUNK/MAK-V was identified from a mammary tumor in an MMTV-neu transgenic mouse. It is required for the metastasis of c-myc-induced mammary tumors, but is not necessary for c-myc-induced primary tumor formation or normal development. It is required for HER2/neu-induced tumor formation and maintenance of the cells' tumorigenic phenotype. It is over-expressed in aggressive subsets of ovary, colon, and breast carcinomas. HUNK interacts with synaptopodin, and may also play a role in synaptic plasticity. The HUNK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270972 [Multi-domain]  Cd Length: 262  Bit Score: 102.59  E-value: 3.88e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEV-RNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd14070   31 AIKVIDKKKAKKDSYVtKNLRREGRIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHRIYDKKRLEEREARRYIR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDF---NIATIIKDGERATALAGTKPYMAPEIFhsfvnGGTGYSFE 158
Cdd:cd14070  111 QLVSAVEHLHRAGVVHRDLKIENLLLDENDNIKLIDFglsNCAGILGYSDPFSTQCGSPAYAAPELL-----ARKKYGPK 185
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDIHSSNaVESLVQLFSTVSVQYVPT-WSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd14070  186 VDVWSIGVNMYAMLTGTLPFTVEPFS-LRALHQKMVDKEMNPLPTdLSPGAISFLRSLLEPDPLKRPNIKQALA 258
STKc_TSSK4-like cd14162
Catalytic domain of testis-specific serine/threonine kinase 4 and similar proteins; STKs ...
3-241 4.02e-25

Catalytic domain of testis-specific serine/threonine kinase 4 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK4, also called TSSK5, is expressed in testis from haploid round spermatids to mature spermatozoa. It phosphorylates Cre-Responsive Element Binding protein (CREB), facilitating the binding of CREB to the specific cis cAMP responsive element (CRE), which is important in activating genes related to germ cell differentiation. Mutations in the human TSSK4 gene is associated with infertile Chinese men with impaired spermatogenesis. The TSSK4-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271064 [Multi-domain]  Cd Length: 259  Bit Score: 102.38  E-value: 4.02e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCieRDEVRNVF--RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14162   29 AIKIVSKKKA--PEDYLQKFlpREIEVIKGLKHPNLICFYEAIETTSRVYIIMELAENGDLLDYIRKNGALPEPQARRWF 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIA---TIIKDGER--ATALAGTKPYMAPEIFHsfvngGTGY 155
Cdd:cd14162  107 RQLVAGVEYCHSKGVVHRDLKCENLLLDKNNNLKITDFGFArgvMKTKDGKPklSETYCGSYAYASPEILR-----GIPY 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 156 S-FEVDWWSVGVMAYELLRGWRPYDihSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEhRFsslqdmqTAP 234
Cdd:cd14162  182 DpFLSDIWSMGVVLYTMVYGRLPFD--DSNLKVLLKQVQRRVVFPKNPTVSEECKDLILRMLSPVKK-RI-------TIE 251

                 ....*..
gi 247269852 235 SLAHVLW 241
Cdd:cd14162  252 EIKRDPW 258
STKc_Mnk2 cd14173
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase ...
2-178 4.44e-25

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271075 [Multi-domain]  Cd Length: 288  Bit Score: 103.18  E-value: 4.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVrnvFRELEILQEIE-HVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14173   30 YAVKIIEKRPGHSRSRV---FREVEMLYQCQgHRNVLELIEFFEEEDKFYLVFEKMRGGSILSHIHRRRHFNELEASVVV 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILL---DEQGHAHLTDFNIATIIKDGERATALA--------GTKPYMAPEIFHSFV 149
Cdd:cd14173  107 QDIASALDFLHNKGIAHRDLKPENILCehpNQVSPVKICDFDLGSGIKLNSDCSPIStpelltpcGSAEYMAPEVVEAFN 186
                        170       180
                 ....*....|....*....|....*....
gi 247269852 150 NGGTGYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd14173  187 EEASIYDKRCDLWSLGVILYIMLSGYPPF 215
STKc_DAPK3 cd14195
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 3; STKs ...
2-231 7.95e-25

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK3, also called DAP-like kinase (DLK) and zipper-interacting protein kinase (ZIPk), contains an N-terminal kinase domain and a C-terminal region with nuclear localization signals (NLS) and a leucine zipper motif that mediates homodimerization and interaction with other leucine zipper proteins. It interacts with Par-4, a protein that contains a death domain and interacts with actin filaments. DAPK3 is present in both the cytoplasm and nucleus. Its co-expression with Par-4 results in the co-localization of the two proteins to actin filaments. In addition to cell death, DAPK3 is also implicated in mediating cell motility and the contraction of smooth muscles. The DAPK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271097 [Multi-domain]  Cd Length: 271  Bit Score: 102.00  E-value: 7.95e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQC------IERDEVRnvfRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDT 75
Cdd:cd14195   33 YAAKFIKKRRLsssrrgVSREEIE---REVNILREIQHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEEE 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  76 VRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQG----HAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSFVNG 151
Cdd:cd14195  110 ATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNvpnpRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLG 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 152 gtgysFEVDWWSVGVMAYELLRGWRPYdiHSSNAVESLVQLfSTVSV----QYVPTWSKEMVALLRKLLTVNPEHRFSSL 227
Cdd:cd14195  190 -----LEADMWSIGVITYILLSGASPF--LGETKQETLTNI-SAVNYdfdeEYFSNTSELAKDFIRRLLVKDPKKRMTIA 261

                 ....
gi 247269852 228 QDMQ 231
Cdd:cd14195  262 QSLE 265
STKc_DAPK cd14105
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase; STKs ...
2-178 9.20e-25

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK1 is the prototypical member of the subfamily and is also simply referred to as DAPK. DAPK2 is also called DAPK-related protein 1 (DRP-1), while DAPK3 has also been named DAP-like kinase (DLK) and zipper-interacting protein kinase (ZIPk). These proteins are ubiquitously expressed in adult tissues, are capable of cross talk with each other, and may act synergistically in regulating cell death. The DAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271007 [Multi-domain]  Cd Length: 269  Bit Score: 101.80  E-value: 9.20e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQC------IERDEVRnvfRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDT 75
Cdd:cd14105   33 YAAKFIKKRRSkasrrgVSREDIE---REVSILRQVLHPNIITLHDVFENKTDVVLILELVAGGELFDFLAEKESLSEEE 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  76 VRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQG----HAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSFVNG 151
Cdd:cd14105  110 ATEFLKQILDGVNYLHTKNIAHFDLKPENIMLLDKNvpipRIKLIDFGLAHKIEDGNEFKNIFGTPEFVAPEIVNYEPLG 189
                        170       180
                 ....*....|....*....|....*..
gi 247269852 152 gtgysFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd14105  190 -----LEADMWSIGVITYILLSGASPF 211
STKc_PAK_I cd06647
Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze ...
3-178 1.25e-24

Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Group I PAKs, also called conventional PAKs, include PAK1, PAK2, and PAK3. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). They interact with the SH3 domain containing proteins Nck, Grb2 and PIX. Binding of group I PAKs to activated GTPases leads to conformational changes that destabilize the AID, allowing autophosphorylation and full activation of the kinase domain. Known group I PAK substrates include MLCK, Bad, Raf, MEK1, LIMK, Merlin, Vimentin, Myc, Stat5a, and Aurora A, among others. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs are implicated in the regulation of many cellular processes including growth factor receptor-mediated proliferation, cell polarity, cell motility, cell death and survival, and actin cytoskeleton organization. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270814 [Multi-domain]  Cd Length: 261  Bit Score: 101.16  E-value: 1.25e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNvfrELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRyHLQQNVQFSEDTVRLYICE 82
Cdd:cd06647   36 AIKQMNLQQQPKKELIIN---EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT-DVVTETCMDEGQIAAVCRE 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNI-ATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEVDW 161
Cdd:cd06647  112 CLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPEQSKRSTMVGTPYWMAPEVVTR-----KAYGPKVDI 186
                        170
                 ....*....|....*..
gi 247269852 162 WSVGVMAYELLRGWRPY 178
Cdd:cd06647  187 WSLGIMAIEMVEGEPPY 203
STKc_PLK1 cd14187
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1; STKs catalyze the ...
1-244 1.39e-24

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK1 functions as a positive regulator of mitosis, meiosis, and cytokinesis. Its localization changes during mitotic progression; associating first with centrosomes in prophase, with kinetochores in prometaphase and metaphase, at the central spindle in anaphase, and in the midbody during telophase. It carries multiple functions throughout the cell cycle through interactions with differrent substrates at these specific subcellular locations. PLK1 is overexpressed in many human cancers and is associated with poor prognosis. The PLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271089 [Multi-domain]  Cd Length: 265  Bit Score: 101.16  E-value: 1.39e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14187   34 VFAGKIVPKSLLLKPHQKEKMSMEIAIHRSLAHQHVVGFHGFFEDNDFVYVVLELCRRRSLLELHKRRKALTEPEARYYL 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIK-DGERATALAGTKPYMAPEIFhsfvnGGTGYSFEV 159
Cdd:cd14187  114 RQIILGCQYLHRNRVIHRDLKLGNLFLNDDMEVKIGDFGLATKVEyDGERKKTLCGTPNYIAPEVL-----SKKGHSFEV 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 160 DWWSVGVMAYELLRGWRPYDihSSNAVESLVQLFS---TVSVQYVPTWSkemvALLRKLLTVNPEHRfsslqdmqtaPSL 236
Cdd:cd14187  189 DIWSIGCIMYTLLVGKPPFE--TSCLKETYLRIKKneySIPKHINPVAA----SLIQKMLQTDPTAR----------PTI 252

                 ....*...
gi 247269852 237 AHVLWDDL 244
Cdd:cd14187  253 NELLNDEF 260
STKc_PSKH1 cd14087
Catalytic domain of the Protein Serine/Threonine kinase H1; STKs catalyze the transfer of the ...
2-231 1.95e-24

Catalytic domain of the Protein Serine/Threonine kinase H1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PSKH1 is an autophosphorylating STK that is expressed ubiquitously and exhibits multiple intracellular localizations including the centrosome, Golgi apparatus, and splice factor compartments. It contains a catalytic kinase domain and an N-terminal SH4-like motif that is acylated to facilitate membrane attachment. PSKH1 plays a rile in the maintenance of the Golgi apparatus, an important organelle within the secretory pathway. It may also function as a novel splice factor and a regulator of prostate cancer cell growth. The PSKH1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270989 [Multi-domain]  Cd Length: 259  Bit Score: 100.69  E-value: 1.95e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQqCIERDEVRNvfrELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRlYIC 81
Cdd:cd14087   29 YAIKMIETK-CRGREVCES---ELNVLRRVRHTNIIQLIEVFETKERVYMVMELATGGELFDRIIAKGSFTERDAT-RVL 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMAL-ALDYLRSQHIIHRDVKPDNILLDEQGHAH---LTDFNIATIIKDGERA--TALAGTKPYMAPEIFHSfvnggTGY 155
Cdd:cd14087  104 QMVLdGVKYLHGLGITHRDLKPENLLYYHPGPDSkimITDFGLASTRKKGPNClmKTTCGTPEYIAPEILLR-----KPY 178
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 156 SFEVDWWSVGVMAYELLRGWRPY-DIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd14087  179 TQSVDMWAVGVIAYILLSGTMPFdDDNRTRLYRQILRAKYSYSGEPWPSVSNLAKDFIDRLLTVNPGERLSATQALK 255
STKc_HAL4_like cd13994
Catalytic domain of Fungal Halotolerance protein 4-like Serine/Threonine kinases; STKs ...
2-225 2.01e-24

Catalytic domain of Fungal Halotolerance protein 4-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of HAL4, Saccharomyces cerevisiae Ptk2/Stk2, and similar fungal proteins. Proteins in this subfamily are involved in regulating ion transporters. In budding and fission yeast, HAL4 promotes potassium ion uptake, which increases cellular resistance to other cations such as sodium, lithium, and calcium ions. HAL4 stabilizes the major high-affinity K+ transporter Trk1 at the plasma membrane under low K+ conditions, which prevents endocytosis and vacuolar degradation. Budding yeast Ptk2 phosphorylates and regulates the plasma membrane H+ ATPase, Pma1. The HAL4-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270896 [Multi-domain]  Cd Length: 265  Bit Score: 100.84  E-value: 2.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQ--QCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMF-MVVDLLLGGDLRYHLQQNVQFSEDTVRL 78
Cdd:cd13994   23 YAVKEYRRRddESKRKDYVKRLTSEYIISSKLHHPNIVKVLDLCQDLHGKWcLVMEYCPGGDLFTLIEKADSLSLEEKDC 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATA-----LAGTKPYMAPEIFHSfvnggt 153
Cdd:cd13994  103 FFKQILRGVAYLHSHGIAHRDLKPENILLDEDGVLKLTDFGTAEVFGMPAEKESpmsagLCGSEPYMAPEVFTS------ 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 154 gYSFE---VDWWSVGVMAYELLRGWRPYDIHSSN-----AVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFS 225
Cdd:cd13994  177 -GSYDgraVDVWSCGIVLFALFTGRFPWRSAKKSdsaykAYEKSGDFTNGPYEPIENLLPSECRRLIYRMLHPDPEKRIT 255
STKc_PAK6 cd06659
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6; STKs catalyze the ...
3-236 2.24e-24

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK6 may play a role in stress responses through its activation by the mitogen-activated protein kinase (MAPK) p38 and MAPK kinase 6 (MKK6) pathway. PAK6 is highly expressed in the brain. It is not required for viability, but together with PAK5, it is required for normal levels of locomotion and activity, and for learning and memory. Increased expression of PAK6 is found in primary and metastatic prostate cancer. PAK6 may play a role in the regulation of motility. PAK6 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270821 [Multi-domain]  Cd Length: 297  Bit Score: 101.22  E-value: 2.24e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMN--KQQcieRDEVrnVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQnVQFSEDTVRLyI 80
Cdd:cd06659   50 AVKMMDlrKQQ---RREL--LFNEVVIMRDYQHPNVVEMYKSYLVGEELWVLMEYLQGGALTDIVSQ-TRLNEEQIAT-V 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMAL-ALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNI-ATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFE 158
Cdd:cd06659  123 CEAVLqALAYLHSQGVIHRDIKSDSILLTLDGRVKLSDFGFcAQISKDVPKRKSLVGTPYWMAPEVISR-----CPYGTE 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYdiHSSNAVESLVQLFST--VSVQYVPTWSKEMVALLRKLLTVNPEHRfSSLQDMQTAPSL 236
Cdd:cd06659  198 VDIWSLGIMVIEMVDGEPPY--FSDSPVQAMKRLRDSppPKLKNSHKASPVLRDFLERMLVRDPQER-ATAQELLDHPFL 274
STKc_Twitchin_like cd14114
The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin; STKs ...
2-225 4.44e-24

The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Caenorhabditis elegans and Aplysia californica Twitchin, Drosophila melanogaster Projectin, and similar proteins. These are very large muscle proteins containing multiple immunoglobulin (Ig)-like and fibronectin type III (FN3) domains and a single kinase domain near the C-terminus. Twitchin and Projectin are both associated with thick filaments. Twitchin is localized in the outer parts of A-bands and is involved in regulating muscle contraction. It interacts with the myofibrillar proteins myosin and actin in a phosphorylation-dependent manner, and may be involved in regulating the myosin cross-bridge cycle. The kinase activity of Twitchen is activated by Ca2+ and the Ca2+ binding protein S100A1. Projectin is associated with the end of thick filaments and is a component of flight muscle connecting filaments. The kinase domain of Projectin may play roles in autophosphorylation and transphosphorylation, which impact the formation of myosin filaments. The Twitchin-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271016 [Multi-domain]  Cd Length: 259  Bit Score: 99.58  E-value: 4.44e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRnvfRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL-QQNVQFSEDTVRLYI 80
Cdd:cd14114   30 FAAKFIMTPHESDKETVR---KEIQIMNQLHHPKLINLHDAFEDDNEMVLILEFLSGGELFERIaAEHYKMSEAEVINYM 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQ--GHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFE 158
Cdd:cd14114  107 RQVCEGLCHMHENNIVHLDIKPENIMCTTKrsNEVKLIDFGLATHLDPKESVKVTTGTAEFAAPEIVE-----REPVGFY 181
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 247269852 159 VDWWSVGVMAYELLRGWRPY----DIHSSNAVESLVQLFSTVSVQYVptwSKEMVALLRKLLTVNPEHRFS 225
Cdd:cd14114  182 TDMWAVGVLSYVLLSGLSPFagenDDETLRNVKSCDWNFDDSAFSGI---SEEAKDFIRKLLLADPNKRMT 249
STKc_PKD cd14082
Catalytic domain of the Serine/Threonine kinase, Protein Kinase D; STKs catalyze the transfer ...
24-225 5.15e-24

Catalytic domain of the Serine/Threonine kinase, Protein Kinase D; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKDs are important regulators of many intracellular signaling pathways such as ERK and JNK, and cellular processes including the organization of the trans-Golgi network, membrane trafficking, cell proliferation, migration, and apoptosis. They contain N-terminal cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. Mammals harbor three types of PKDs: PKD1 (or PKCmu), PKD2, and PKD3 (or PKCnu). PKDs are activated in a PKC-dependent manner by many agents including diacylglycerol (DAG), PDGF, neuropeptides, oxidative stress, and tumor-promoting phorbol esters, among others. The PKD subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270984 [Multi-domain]  Cd Length: 260  Bit Score: 99.41  E-value: 5.15e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  24 ELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL-QQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKP 102
Cdd:cd14082   52 EVAILQQLSHPGVVNLECMFETPERVFVVMEKLHGDMLEMILsSEKGRLPERITKFLVTQILVALRYLHSKNIVHCDLKP 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 103 DNILLDEQG---HAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELLRGWRPYd 179
Cdd:cd14082  132 ENVLLASAEpfpQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRN-----KGYNRSLDMWSVGVIIYVSLSGTFPF- 205
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 247269852 180 ihssNAVESLVQLFSTVSVQYVPT-W---SKEMVALLRKLLTVNPEHRFS 225
Cdd:cd14082  206 ----NEDEDINDQIQNAAFMYPPNpWkeiSPDAIDLINNLLQVKMRKRYS 251
STKc_Nek9 cd08221
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
17-223 5.75e-24

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek9, also called Nercc1, is primarily a cytoplasmic protein but can also localize in the nucleus. It is involved in modulating chromosome alignment and splitting during mitosis. It interacts with the gamma-tubulin ring complex and the Ran GTPase, and is implicated in microtubule organization. Nek9 associates with FACT (FAcilitates Chromatin Transcription) and modulates interphase progression. It also interacts with Nek6, and Nek7, during mitosis, resulting in their activation. Nek9 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270860 [Multi-domain]  Cd Length: 256  Bit Score: 99.04  E-value: 5.75e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  17 EVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDL--RYHLQQNVQFSEDTVRLYICEMALALDYLRSQH 94
Cdd:cd08221   42 ERRDALNEIDILSLLNHDNIITYYNHFLDGESLFIEMEYCNGGNLhdKIAQQKNQLFPEEVVLWYLYQIVSAVSHIHKAG 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  95 IIHRDVKPDNILLDEQGHAHLTDFNIATIIK-DGERATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLR 173
Cdd:cd08221  122 ILHRDIKTLNIFLTKADLVKLGDFGISKVLDsESSMAESIVGTPYYMSPELVQ-----GVKYNFKSDIWAVGCVLYELLT 196
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 247269852 174 GWRPYDihSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHR 223
Cdd:cd08221  197 LKRTFD--ATNPLRLAVKIVQGEYEDIDEQYSEEIIQLVHDCLHQDPEDR 244
STKc_MEKK4 cd06626
Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP) ...
3-223 5.77e-24

Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK4 is a MAPK kinase kinase that phosphorylates and activates the c-Jun N-terminal kinase (JNK) and p38 MAPK signaling pathways by directly activating their respective MAPKKs, MKK4/MKK7 and MKK3/MKK6. JNK and p38 are collectively known as stress-activated MAPKs, as they are activated in response to a variety of environmental stresses and pro-inflammatory cytokines. MEKK4 also plays roles in the re-polarization of the actin cytoskeleton in response to osmotic stress, in the proper closure of the neural tube, in cardiovascular development, and in immune responses. The MEKK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270796 [Multi-domain]  Cd Length: 265  Bit Score: 99.30  E-value: 5.77e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQcIERDEVRNVFRELEILQEIEHVFLVNlWYSFQ---DEEDMFMvvDLLLGGDLRYHLQQNVQFSEDTVRLY 79
Cdd:cd06626   29 AMKEIRFQD-NDPKTIKEIADEMKVLEGLDHPNLVR-YYGVEvhrEEVYIFM--EYCQEGTLEELLRHGRILDEAVIRVY 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATA------LAGTKPYMAPEIFHSfvNGGT 153
Cdd:cd06626  105 TLQLLEGLAYLHENGIVHRDIKPANIFLDSNGLIKLGDFGSAVKLKNNTTTMApgevnsLVGTPAYMAPEVITG--NKGE 182
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 154 GYSFEVDWWSVGVMAYELLRGWRPYDIHSSNaveslVQLFSTVSVQYVPT------WSKEMVALLRKLLTVNPEHR 223
Cdd:cd06626  183 GHGRAADIWSLGCVVLEMATGKRPWSELDNE-----WAIMYHVGMGHKPPipdslqLSPEGKDFLSRCLESDPKKR 253
STKc_CaMKK2 cd14199
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2; ...
2-225 6.87e-24

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). CaMKK2, also called CaMKK beta, is one of the most versatile CaMKs. It is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. CaMKK2 contains unique N- and C-terminal domains and a central catalytic kinase domain that is followed by a regulatory domain that bears overlapping autoinhibitory and CaM-binding regions. It can be activated by signaling through G-coupled receptors, IP3 receptors, plasma membrane ion channels, and Toll-like receptors. Thus, CaMKK2 acts as a molecular hub that is capable of receiving and decoding signals from diverse pathways. The CaMKK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271101 [Multi-domain]  Cd Length: 286  Bit Score: 99.65  E-value: 6.87e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQ----------------------CIE-RDEVRNVFRELEILQEIEHVFLVNLWYSFQD--EEDMFMVVDLL 56
Cdd:cd14199   30 YAMKVLSKKKlmrqagfprrppprgaraapegCTQpRGPIERVYQEIAILKKLDHPNVVKLVEVLDDpsEDHLYMVFELV 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  57 LGGDLrYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKdGERA--TALA 134
Cdd:cd14199  110 KQGPV-MEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDVKPSNLLVGEDGHIKIADFGVSNEFE-GSDAllTNTV 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 135 GTKPYMAPEIFHSFVNGGTGYSFEVdwWSVGVMAYELLRGWRPYdihssnAVESLVQLFSTVSVQYV-----PTWSKEMV 209
Cdd:cd14199  188 GTPAFMAPETLSETRKIFSGKALDV--WAMGVTLYCFVFGQCPF------MDERILSLHSKIKTQPLefpdqPDISDDLK 259
                        250
                 ....*....|....*.
gi 247269852 210 ALLRKLLTVNPEHRFS 225
Cdd:cd14199  260 DLLFRMLDKNPESRIS 275
PKc_Byr1_like cd06620
Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases; ...
17-230 7.92e-24

Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Byr1 from Schizosaccharomyces pombe, FUZ7 from Ustilago maydis, and related proteins. Byr1 phosphorylates its downstream target, the MAPK Spk1, and is regulated by the MAPKK kinase Byr2. The Spk1 cascade is pheromone-responsive and is essential for sporulation and sexual differentiation in fission yeast. FUZ7 phosphorylates and activates its target, the MAPK Crk1, which is required in mating and virulence in U. maydis. MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The Byr-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270792 [Multi-domain]  Cd Length: 286  Bit Score: 99.44  E-value: 7.92e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  17 EVRN-VFRELEILQEIEHVFLVNLWYSFQDEE-DMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQH 94
Cdd:cd06620   45 SVRKqILRELQILHECHSPYIVSFYGAFLNENnNIIICMEYMDCGSLDKILKKKGPFPEEVLGKIAVAVLEGLTYLYNVH 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  95 -IIHRDVKPDNILLDEQGHAHLTDFNIAtiikdGERATALA----GTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAY 169
Cdd:cd06620  125 rIIHRDIKPSNILVNSKGQIKLCDFGVS-----GELINSIAdtfvGTSTYMSPERIQ-----GGKYSVKSDVWSLGLSII 194
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 247269852 170 ELLRGWRPYDIH-----SSNAVESLVQLFSTVSVQYVPT------WSKEMVALLRKLLTVNPEHRfSSLQDM 230
Cdd:cd06620  195 ELALGEFPFAGSnddddGYNGPMGILDLLQRIVNEPPPRlpkdriFPKDLRDFVDRCLLKDPRER-PSPQLL 265
STKc_STK10 cd06644
Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase ...
16-228 1.06e-23

Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK10/LOK is also called polo-like kinase kinase 1 in Xenopus (xPlkk1). It is highly expressed in lymphocytes and is responsible in regulating leukocyte function associated antigen (LFA-1)-mediated lymphocyte adhesion. It plays a role in regulating the CD28 responsive element in T cells, and may also function as a regulator of polo-like kinase 1 (Plk1), a protein which is overexpressed in multiple tumor types. The STK10 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132975 [Multi-domain]  Cd Length: 292  Bit Score: 99.34  E-value: 1.06e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  16 DEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDL-RYHLQQNVQFSEDTVRLYICEMALALDYLRSQH 94
Cdd:cd06644   51 EELEDYMVEIEILATCNHPYIVKLLGAFYWDGKLWIMIEFCPGGAVdAIMLELDRGLTEPQIQVICRQMLEALQYLHSMK 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  95 IIHRDVKPDNILLDEQGHAHLTDFNI-ATIIKDGERATALAGTKPYMAPEIFHSFVNGGTGYSFEVDWWSVGVMAYELLR 173
Cdd:cd06644  131 IIHRDLKAGNVLLTLDGDIKLADFGVsAKNVKTLQRRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQ 210
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 174 GWRPYdiHSSNAVESLVQLFST--VSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd06644  211 IEPPH--HELNPMRVLLKIAKSepPTLSQPSKWSMEFRDFLKTALDKHPETRPSAAQ 265
STKc_PAK_II cd06648
Catalytic domain of the Serine/Threonine Kinase, Group II p21-activated kinase; STKs catalyze ...
3-178 1.17e-23

Catalytic domain of the Serine/Threonine Kinase, Group II p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Group II PAKs, also called non-conventional PAKs, include PAK4, PAK5, and PAK6. Group II PAKs contain PBD (p21-binding domain) and catalytic domains, but lack other motifs found in group I PAKs, such as an AID (autoinhibitory domain) and SH3 binding sites. Since group II PAKs do not contain an obvious AID, they may be regulated differently from group I PAKs. While group I PAKs interact with the SH3 containing proteins Nck, Grb2 and PIX, no such binding has been demonstrated for group II PAKs. Some known substrates of group II PAKs are also substrates of group I PAKs such as Raf, BAD, LIMK and GEFH1. Unique group II substrates include MARK/Par-1 and PDZ-RhoGEF. Group II PAKs play important roles in filopodia formation, neuron extension, cytoskeletal organization, and cell survival. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270815 [Multi-domain]  Cd Length: 261  Bit Score: 98.67  E-value: 1.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMN--KQQcieRDEVrnVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQnVQFSEDTVRlYI 80
Cdd:cd06648   36 AVKKMDlrKQQ---RREL--LFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFLEGGALTDIVTH-TRMNEEQIA-TV 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMAL-ALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNI-ATIIKDGERATALAGTKPYMAPEIFHSFVnggtgYSFE 158
Cdd:cd06648  109 CRAVLkALSFLHSQGVIHRDIKSDSILLTSDGRVKLSDFGFcAQVSKEVPRRKSLVGTPYWMAPEVISRLP-----YGTE 183
                        170       180
                 ....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPY 178
Cdd:cd06648  184 VDIWSLGIMVIEMVDGEPPY 203
STKc_MLCK3 cd14192
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3; STKs catalyze ...
3-231 1.56e-23

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK3 (or MYLK3) phosphorylates myosin regulatory light chain 2 and controls the contraction of cardiac muscles. It is expressed specifically in both the atrium and ventricle of the heart and its expression is regulated by the cardiac protein Nkx2-5. MLCK3 plays an important role in cardiogenesis by regulating the assembly of cardiac sarcomeres, the repeating contractile unit of striated muscle. MLCK3 contains a single kinase domain near the C-terminus and a unique N-terminal half, and unlike MLCK1/2, it does not appear to be regulated by Ca2+/calmodulin. The MLCK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271094 [Multi-domain]  Cd Length: 261  Bit Score: 98.11  E-value: 1.56e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNvfrELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL-QQNVQFSEDTVRLYIC 81
Cdd:cd14192   33 AAKIIKVKGAKEREEVKN---EINIMNQLNHVNLIQLYDAFESKTNLTLIMEYVDGGELFDRItDESYQLTELDAILFTR 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNIL-LDEQGHA-HLTDFNIATIIKDGERATALAGTKPYMAPEIF-HSFVnggtgySFE 158
Cdd:cd14192  110 QICEGVHYLHQHYILHLDLKPENILcVNSTGNQiKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVnYDFV------SFP 183
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 159 VDWWSVGVMAYELLRGWRPY----DIHSSNAVESLVQLFSTVSVQYVPTWSKEMVAllrKLLTVNPEHRFSSLQDMQ 231
Cdd:cd14192  184 TDMWSVGVITYMLLSGLSPFlgetDAETMNNIVNCKWDFDAEAFENLSEEAKDFIS---RLLVKEKSCRMSATQCLK 257
STKc_SLK cd06643
Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase; STKs catalyze the transfer ...
16-231 1.60e-23

Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SLK promotes apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and the mitogen-activated protein kinase (MAPK) p38. It acts as a MAPK kinase kinase by phosphorylating ASK1, resulting in the phosphorylation of p38. SLK also plays a role in mediating actin reorganization. It is part of a microtubule-associated complex that is targeted at adhesion sites, and is required in focal adhesion turnover and in regulating cell migration. The SLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270811 [Multi-domain]  Cd Length: 283  Bit Score: 98.56  E-value: 1.60e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  16 DEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDL-RYHLQQNVQFSEDTVRLyICEMAL-ALDYLRSQ 93
Cdd:cd06643   44 EELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVdAVMLELERPLTEPQIRV-VCKQTLeALVYLHEN 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  94 HIIHRDVKPDNILLDEQGHAHLTDFNI-ATIIKDGERATALAGTKPYMAPEIFHSFVNGGTGYSFEVDWWSVGVMAYELL 172
Cdd:cd06643  123 KIIHRDLKAGNILFTLDGDIKLADFGVsAKNTRTLQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGVTLIEMA 202
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 247269852 173 RGWRPYdiHSSNAVESLVQLFST--VSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd06643  203 QIEPPH--HELNPMRVLLKIAKSepPTLAQPSRWSPEFKDFLRKCLEKNVDARWTTSQLLQ 261
STKc_Pat1_like cd13993
Catalytic domain of Fungal Pat1-like Serine/Threonine kinases; STKs catalyze the transfer of ...
2-233 1.63e-23

Catalytic domain of Fungal Pat1-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Pat1 (also called Ran1), Saccharomyces cerevisiae VHS1 and KSP1, and similar fungal STKs. Pat1 blocks Mei2, an RNA-binding protein which is indispensable in the initiation of meiosis. Pat1 is inactivated and Mei2 activated, which initiates meiosis, under nutrient-deprived conditions through a signaling cascade involving Ste11. Meiosis induced by Pat1 inactivation may show different characteristics than normal meiosis including aberrant positioning of centromeres. VHS1 was identified in a screen for suppressors of cell cycle arrest at the G1/S transition, while KSP1 may be involved in regulating PRP20, which is required for mRNA export and maintenance of nuclear structure. The Pat1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270895 [Multi-domain]  Cd Length: 267  Bit Score: 98.19  E-value: 1.63e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEvrNVFRELEILQEIE-------HVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSED 74
Cdd:cd13993   28 YAIKCLYKSGPNSKDG--NDFQKLPQLREIDlhrrvsrHPNIITLHDVFETEVAIYIVLEYCPNGDLFEAITENRIYVGK 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  75 T--VRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQ-GHAHLTDFNIATIIK-DGERATalaGTKPYMAPEIFHSFVN 150
Cdd:cd13993  106 TelIKNVFLQLIDAVKHCHSLGIYHRDIKPENILLSQDeGTVKLCDFGLATTEKiSMDFGV---GSEFYMAPECFDEVGR 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 151 GGTGYS-FEVDWWSVGVMAYELLRGWRPY-------DIHSSNAV--ESLVQLFSTVsvqyvptwSKEMVALLRKLLTVNP 220
Cdd:cd13993  183 SLKGYPcAAGDIWSLGIILLNLTFGRNPWkiasesdPIFYDYYLnsPNLFDVILPM--------SDDFYNLLRQIFTVNP 254
                        250
                 ....*....|...
gi 247269852 221 EHRfSSLQDMQTA 233
Cdd:cd13993  255 NNR-ILLPELQLL 266
STKc_CaMKII cd14086
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
2-231 1.69e-23

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKs contain an N-terminal catalytic domain followed by a regulatory domain that harbors a CaM binding site. In addition, CaMKII contains a C-terminal association domain that facilitates oligomerization. There are four CaMKII proteins (alpha, beta, gamma, delta) encoded by different genes; each gene undergoes alternative splicing to produce more than 30 isoforms. CaMKII-alpha and -beta are enriched in neurons while CaMKII-gamma and -delta are predominant in myocardium. CaMKII is a signaling molecule that translates upstream calcium and reactive oxygen species (ROS) signals into downstream responses that play important roles in synaptic function and cardiovascular physiology. It is a major component of the postsynaptic density and is critical in regulating synaptic plasticity including long-term potentiation. It is critical in regulating ion channels and proteins involved in myocardial excitation-contraction and excitation-transcription coupling. Excessive CaMKII activity promotes processes that contribute to heart failure and arrhythmias. The CaMKII subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270988 [Multi-domain]  Cd Length: 292  Bit Score: 98.65  E-value: 1.69e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDeVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd14086   29 FAAKIINTKKLSARD-HQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQ 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILL---DEQGHAHLTDFNIATIIKDGERA-TALAGTKPYMAPEIFHSfvnggTGYSF 157
Cdd:cd14086  108 QILESVNHCHQNGIVHRDLKPENLLLaskSKGAAVKLADFGLAIEVQGDQQAwFGFAGTPGYLSPEVLRK-----DPYGK 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 158 EVDWWSVGVMAYELLRGWRPY---DIHssnaveSLVQLFSTVSVQY-VPTWS---KEMVALLRKLLTVNPEHRFSSLQDM 230
Cdd:cd14086  183 PVDIWACGVILYILLVGYPPFwdeDQH------RLYAQIKAGAYDYpSPEWDtvtPEAKDLINQMLTVNPAKRITAAEAL 256

                 .
gi 247269852 231 Q 231
Cdd:cd14086  257 K 257
PKc_Pek1_like cd06621
Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases; ...
19-249 1.75e-23

Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Pek1/Skh1 from Schizosaccharomyces pombe and MKK2 from Saccharomyces cerevisiae, and related proteins. Both fission yeast Pek1 and baker's yeast MKK2 are components of the cell integrity MAPK pathway. In fission yeast, Pek1 phosphorylates and activates Pmk1/Spm1 and is regulated by the MAPKK kinase Mkh1. In baker's yeast, the pathway involves the MAPK Slt2, the MAPKKs MKK1 and MKK2, and the MAPKK kinase Bck1. The cell integrity MAPK cascade is activated by multiple stress conditions, and is essential in cell wall construction, morphogenesis, cytokinesis, and ion homeostasis. MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270793 [Multi-domain]  Cd Length: 287  Bit Score: 98.65  E-value: 1.75e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  19 RNVFRELEILQEIEHVFLVNLWYSFQDEED--MFMVVDLLLGGDL----RYHLQQNVQFSEdTVRLYICEMAL-ALDYLR 91
Cdd:cd06621   44 KQILRELEINKSCASPYIVKYYGAFLDEQDssIGIAMEYCEGGSLdsiyKKVKKKGGRIGE-KVLGKIAESVLkGLSYLH 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  92 SQHIIHRDVKPDNILLDEQGHAHLTDFNIAtiikdGERATALA----GTKPYMAPEifhsFVNGGTgYSFEVDWWSVGVM 167
Cdd:cd06621  123 SRKIIHRDIKPSNILLTRKGQVKLCDFGVS-----GELVNSLAgtftGTSYYMAPE----RIQGGP-YSITSDVWSLGLT 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 168 AYELLRGWRPYDIHSSNAVeSLVQLFSTVSVQYVP----------TWSKEMVALLRKLLTVNPEHRFSSlQDMqtapsLA 237
Cdd:cd06621  193 LLEVAQNRFPFPPEGEPPL-GPIELLSYIVNMPNPelkdepengiKWSESFKDFIEKCLEKDGTRRPGP-WQM-----LA 265
                        250
                 ....*....|..
gi 247269852 238 HVLWDDLSEKKV 249
Cdd:cd06621  266 HPWIKAQEKKKV 277
STKc_Nek3 cd08219
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
1-226 3.58e-23

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek3 is primarily localized in the cytoplasm and shows no cell cycle-dependent changes in its activity. It is present in the axons of neurons and affects morphogenesis and polarity through its regulation of microtubule acetylation. Nek3 modulates the signaling of the prolactin receptor through its activation of Vav2 and contributes to prolactin-mediated motility of breast cancer cells. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173759 [Multi-domain]  Cd Length: 255  Bit Score: 96.97  E-value: 3.58e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQciERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDL--RYHLQQNVQFSEDTVRL 78
Cdd:cd08219   27 KYAMKEIRLPK--SSSAVEDSRKEAVLLAKMKHPNIVAFKESFEADGHLYIVMEYCDGGDLmqKIKLQRGKLFPEDTILQ 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKD-GERATALAGTKPYMAPEIFHSFvnggtGYSF 157
Cdd:cd08219  105 WFVQMCLGVQHIHEKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLTSpGAYACTYVGTPYYVPPEIWENM-----PYNN 179
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 158 EVDWWSVGVMAYELLRGWRPYdihSSNAVESLVQLFSTVSVQYVPT-WSKEMVALLRKLLTVNPEHRFSS 226
Cdd:cd08219  180 KSDIWSLGCILYELCTLKHPF---QANSWKNLILKVCQGSYKPLPShYSYELRSLIKQMFKRNPRSRPSA 246
PK_Tyr_Ser-Thr pfam07714
Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role ...
15-228 6.62e-23

Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyze the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyze the reverse process. Protein kinases fall into three broad classes, characterized with respect to substrate specificity; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.


Pssm-ID: 462242 [Multi-domain]  Cd Length: 258  Bit Score: 96.41  E-value: 6.62e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   15 RDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQ-FSEDTVRLYICEMALALDYLRSQ 93
Cdd:pfam07714  42 EEEREDFLEEASIMKKLDHPNIVKLLGVCTQGEPLYIVTEYMPGGDLLDFLRKHKRkLTLKDLLSMALQIAKGMEYLESK 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   94 HIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTK---PYMAPEIFHSFVnggtgYSFEVDWWSVGVMAYE 170
Cdd:pfam07714 122 NFVHRDLAARNCLVSENLVVKISDFGLSRDIYDDDYYRKRGGGKlpiKWMAPESLKDGK-----FTSKSDVWSFGVLLWE 196
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852  171 LL-RGWRPY-DIHSSNAVESLVQlfstvsvQYV----PTWSKEMVALLRKLLTVNPEHR--FSSLQ 228
Cdd:pfam07714 197 IFtLGEQPYpGMSNEEVLEFLED-------GYRlpqpENCPDELYDLMKQCWAYDPEDRptFSELV 255
STKc_PLK4 cd14186
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4; STKs catalyze the ...
3-225 8.65e-23

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK4, also called SAK or STK18, is structurally different from other PLKs in that it contains only one polo box that can form two adjacent polo boxes and a functional PDB by homodimerization. It is required for late mitotic progression, cell survival, and embryonic development. It localizes to centrosomes and is required for centriole duplication and chromosomal stability. Overexpression of PLK4 may be associated with colon tumors. The PLK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271088 [Multi-domain]  Cd Length: 256  Bit Score: 96.08  E-value: 8.65e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQ-FSEDTVRLYIC 81
Cdd:cd14186   30 AIKMIDKKAMQKAGMVQRVRNEVEIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMSRYLKNRKKpFTEDEARHFMH 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIK-DGERATALAGTKPYMAPEIFHSfvnggTGYSFEVD 160
Cdd:cd14186  110 QIVTGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKmPHEKHFTMCGTPNYISPEIATR-----SAHGLESD 184
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 247269852 161 WWSVGVMAYELLRGWRPYDihsSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFS 225
Cdd:cd14186  185 VWSLGCMFYTLLVGRPPFD---TDTVKNTLNKVVLADYEMPAFLSREAQDLIHQLLRKNPADRLS 246
STKc_SBK1 cd13987
Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1; STKs catalyze the ...
2-230 1.38e-22

Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SBK1, also called BSK146, is predominantly expressed in the brain. Its expression is increased in the developing brain during the late embryonic stage, coinciding with dramatic neuronal proliferation, migration, and maturation. SBK1 may play an important role in regulating brain development. The SBK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270889 [Multi-domain]  Cd Length: 259  Bit Score: 95.47  E-value: 1.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVR--NVFRELEILQEIEHVFLVnlwySFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLY 79
Cdd:cd13987   21 MALKFVPKPSTKLKDFLReyNISLELSVHPHIIKTYDV----AFETEDYYVFAQEYAPYGDLFSIIPPQVGLPEERVKRC 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILL--DEQGHAHLTDFNIATiiKDGERATALAGTKPYMAPEIFHSFVNGGTGYSF 157
Cdd:cd13987   97 AAQLASALDFMHSKNLVHRDIKPENVLLfdKDCRRVKLCDFGLTR--RVGSTVKRVSGTIPYTAPEVCEAKKNEGFVVDP 174
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 158 EVDWWSVGVMAYELLRGWRPYDI--HSSNAVESLVQLFSTVSVQYVPTW---SKEMVALLRKLLTVNPEHRfSSLQDM 230
Cdd:cd13987  175 SIDVWAFGVLLFCCLTGNFPWEKadSDDQFYEEFVRWQKRKNTAVPSQWrrfTPKALRMFKKLLAPEPERR-CSIKEV 251
STKc_CaMKIV cd14085
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
2-231 1.39e-22

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKIV is found predominantly in neurons and immune cells. It is activated by the binding of calcium/CaM and phosphorylation by CaMKK (alpha or beta). The CaMKK-CaMKIV cascade participates in regulating several transcription factors like CREB, MEF2, and retinoid orphan receptors. It also is implicated in T-cell development and signaling, cytokine secretion, and signaling through Toll-like receptors, and is thus, pivotal in immune response and inflammation. The CaMKIV subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270987 [Multi-domain]  Cd Length: 294  Bit Score: 96.05  E-value: 1.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQqcIERDEVRNvfrELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSE----DTVR 77
Cdd:cd14085   31 YAVKKLKKT--VDKKIVRT---EIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSErdaaDAVK 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  78 LyICEmalALDYLRSQHIIHRDVKPDNILLDEQGH---AHLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTG 154
Cdd:cd14085  106 Q-ILE---AVAYLHENGIVHRDLKPENLLYATPAPdapLKIADFGLSKIVDQQVTMKTVCGTPGYCAPEILR-----GCA 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 155 YSFEVDWWSVGVMAYELLRGWRP-YDIHSSNaveslvQLFSTV---SVQYVPTW----SKEMVALLRKLLTVNPEHRFSS 226
Cdd:cd14085  177 YGPEVDMWSVGVITYILLCGFEPfYDERGDQ------YMFKRIlncDYDFVSPWwddvSLNAKDLVKKLIVLDPKKRLTT 250

                 ....*
gi 247269852 227 LQDMQ 231
Cdd:cd14085  251 QQALQ 255
STKc_CDK_like cd07829
Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases; STKs ...
2-231 1.70e-22

Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. CDKs are partly regulated by their subcellular localization, which defines substrate phosphorylation and the resulting specific function. CDK1, CDK2, CDK4, and CDK6 have well-defined functions in the cell cycle, such as the regulation of the early G1 phase by CDK4 or CDK6, the G1/S phase transition by CDK2, or the entry of mitosis by CDK1. They also exhibit overlapping cyclin specificity and functions in certain conditions. Knockout mice with a single CDK deleted remain viable with specific phenotypes, showing that some CDKs can compensate for each other. For example, CDK4 can compensate for the loss of CDK6, however, double knockout mice with both CDK4 and CDK6 deleted die in utero. CDK8 and CDK9 are mainly involved in transcription while CDK5 is implicated in neuronal function. CDK7 plays essential roles in both the cell cycle as a CDK-Activating Kinase (CAK) and in transcription as a component of the general transcription factor TFIIH. The CDK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270823 [Multi-domain]  Cd Length: 282  Bit Score: 95.63  E-value: 1.70e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMnkQQCIERDEV-RNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQN-VQFSEDTVRLY 79
Cdd:cd07829   27 VALKKI--RLDNEEEGIpSTALREISLLKELKHPNIVKLLDVIHTENKLYLVFEYC-DQDLKKYLDKRpGPLPPNLIKSI 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAtiikdgeRATALAG---TKP-----YMAPEIFHsfvnG 151
Cdd:cd07829  104 MYQLLRGLAYCHSHRILHRDLKPQNLLINRDGVLKLADFGLA-------RAFGIPLrtyTHEvvtlwYRAPEILL----G 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 152 GTGYSFEVDWWSVGVMAYELLRGwRPYdIHSSNAVESLVQLFSTVSV----------------------------QYVPT 203
Cdd:cd07829  173 SKHYSTAVDIWSVGCIFAELITG-KPL-FPGDSEIDQLFKIFQILGTpteeswpgvtklpdykptfpkwpkndleKVLPR 250
                        250       260
                 ....*....|....*....|....*...
gi 247269852 204 WSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd07829  251 LDPEGIDLLSKMLQYNPAKRISAKEALK 278
STKc_SNRK cd14074
Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase; STKs catalyze the ...
16-236 1.98e-22

Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SNRK is a kinase highly expressed in testis and brain that is found inactive in cells that lack the LKB1 tumour suppressor protein kinase. The regulatory subunits STRAD and MO25 are required for LKB1 to activate SNRK. The SNRK mRNA is increased 3-fold when granule neurons are cultured in low potassium, and may thus play a role in the survival responses in these cells. In some vertebrates, a second SNRK gene (snrkb or snrk-1) has been sequenced and/or identified. Snrk-1 is expressed specifically in embryonic zebrafish vasculature; it plays an essential role in angioblast differentiation, maintenance, and migration. The SNRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270976 [Multi-domain]  Cd Length: 258  Bit Score: 95.17  E-value: 1.98e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  16 DEV--RNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDL-RYHLQQNVQFSEDTVRLYICEMALALDYLRS 92
Cdd:cd14074   42 DDVskAHLFQEVRCMKLVQHPNVVRLYEVIDTQTKLYLILELGDGGDMyDYIMKHENGLNEDLARKYFRQIVSAISYCHK 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILLDE-QGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFhsfvnggTGYSFE---VDWWSVGVMA 168
Cdd:cd14074  122 LHVVHRDLKPENVVFFEkQGLVKLTDFGFSNKFQPGEKLETSCGSLAYSAPEIL-------LGDEYDapaVDIWSLGVIL 194
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 169 YELLRGWRPYdiHSSNAVESLVQLfstVSVQY-VPTW-SKEMVALLRKLLTVNPEHRfSSLQDMQTAPSL 236
Cdd:cd14074  195 YMLVCGQPPF--QEANDSETLTMI---MDCKYtVPAHvSPECKDLIRRMLIRDPKKR-ASLEEIENHPWL 258
STKc_Nek4 cd08223
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
2-226 2.24e-22

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek4 is highly abundant in the testis. Its specific function is unknown. Neks are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. Nek4 is one in a family of 11 different Neks (Nek1-11). The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270862 [Multi-domain]  Cd Length: 257  Bit Score: 94.81  E-value: 2.24e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERdEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDM-FMVVDLLLGGDLRYHL--QQNVQFSEDTVRL 78
Cdd:cd08223   28 YVIKKLNLKNASKR-ERKAAEQEAKLLSKLKHPNIVSYKESFEGEDGFlYIVMGFCEGGDLYTRLkeQKGVLLEERQVVE 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDG-ERATALAGTKPYMAPEIFHSfvnggTGYSF 157
Cdd:cd08223  107 WFVQIAMALQYMHERNILHRDLKTQNIFLTKSNIIKVGDLGIARVLESSsDMATTLIGTPYYMSPELFSN-----KPYNH 181
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 247269852 158 EVDWWSVGVMAYEL--LRgwrpydiHSSNA--VESLVQLFSTVSVQYVPT-WSKEMVALLRKLLTVNPEHRFSS 226
Cdd:cd08223  182 KSDVWALGCCVYEMatLK-------HAFNAkdMNSLVYKILEGKLPPMPKqYSPELGELIKAMLHQDPEKRPSV 248
STKc_MST3_like cd06609
Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases; STKs ...
16-182 2.52e-22

Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MST3, MST4, STK25, Schizosaccharomyces pombe Nak1 and Sid1, Saccharomyces cerevisiae sporulation-specific protein 1 (SPS1), and related proteins. Nak1 is required by fission yeast for polarizing the tips of actin cytoskeleton and is involved in cell growth, cell separation, cell morphology and cell-cycle progression. Sid1 is a component in the septation initiation network (SIN) signaling pathway, and plays a role in cytokinesis. SPS1 plays a role in regulating proteins required for spore wall formation. MST4 plays a role in mitogen-activated protein kinase (MAPK) signaling during cytoskeletal rearrangement, morphogenesis, and apoptosis. MST3 phosphorylates the STK NDR and may play a role in cell cycle progression and cell morphology. STK25 may play a role in the regulation of cell migration and polarization. The MST3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270786 [Multi-domain]  Cd Length: 274  Bit Score: 95.00  E-value: 2.52e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  16 DEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRyHLQQNVQFSEDTVRLYICEMALALDYLRSQHI 95
Cdd:cd06609   41 DEIEDIQQEIQFLSQCDSPYITKYYGSFLKGSKLWIIMEYCGGGSVL-DLLKPGPLDETYIAFILREVLLGLEYLHSEGK 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  96 IHRDVKPDNILLDEQGHAHLTDFNIA-----TIIKdgeRATaLAGTKPYMAPEifhsfVNGGTGYSFEVDWWSVGVMAYE 170
Cdd:cd06609  120 IHRDIKAANILLSEEGDVKLADFGVSgqltsTMSK---RNT-FVGTPFWMAPE-----VIKQSGYDEKADIWSLGITAIE 190
                        170
                 ....*....|...
gi 247269852 171 LLRGWRPY-DIHS 182
Cdd:cd06609  191 LAKGEPPLsDLHP 203
STKc_CDK9_like cd07840
Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases; STKs ...
1-231 2.90e-22

Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK9 and CDK12 from higher eukaryotes, yeast BUR1, C-type plant CDKs (CdkC), and similar proteins. CDK9, BUR1, and CdkC are functionally equivalent. They act as a kinase for the C-terminal domain of RNA polymerase II and participate in regulating mutliple steps of gene expression including transcription elongation and RNA processing. CDK9 and CdkC associate with T-type cyclins while BUR1 associates with the cyclin BUR2. CDK12 is a unique CDK that contains an arginine/serine-rich (RS) domain, which is predominantly found in splicing factors. CDK12 interacts with cyclins L1 and L2, and participates in regulating transcription and alternative splicing. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK9-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270832 [Multi-domain]  Cd Length: 291  Bit Score: 95.32  E-value: 2.90e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQciERDE-VRNVFRELEILQEIEHVFLVNLW------YSFQDEEDMFMVVDLL---LGGDLRyhlQQNVQ 70
Cdd:cd07840   26 LVALKKIRMEN--EKEGfPITAIREIKLLQKLDHPNVVRLKeivtskGSAKYKGSIYMVFEYMdhdLTGLLD---NPEVK 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  71 FSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERA--TALAGTKPYMAPEIFHsf 148
Cdd:cd07840  101 FTESQIKCYMKQLLEGLQYLHSNGILHRDIKGSNILINNDGVLKLADFGLARPYTKENNAdyTNRVITLWYRPPELLL-- 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 149 vnGGTGYSFEVDWWSVG-VMAyELLRGwRPYdIHSSNAVESLVQLFS---TVSVQYVPTWSK----EMVA---------- 210
Cdd:cd07840  179 --GATRYGPEVDMWSVGcILA-ELFTG-KPI-FQGKTELEQLEKIFElcgSPTEENWPGVSDlpwfENLKpkkpykrrlr 253
                        250       260       270
                 ....*....|....*....|....*....|....
gi 247269852 211 -------------LLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd07840  254 evfknvidpsaldLLDKLLTLDPKKRISADQALQ 287
STKc_DRAK cd14106
Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
2-223 3.07e-22

Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs, also called STK17, were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 and DRAK2. Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. They may play a role in apoptotic signaling. The DRAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271008 [Multi-domain]  Cd Length: 268  Bit Score: 94.73  E-value: 3.07e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQcierdevRNVFRELEILQEI-------EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSED 74
Cdd:cd14106   36 YAAKFLRKRR-------RGQDCRNEILHEIavlelckDCPRVVNLHEVYETRSELILILELAAGGELQTLLDEEECLTEA 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  75 TVRLYICEMALALDYLRSQHIIHRDVKPDNILL---DEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvng 151
Cdd:cd14106  109 DVRRLMRQILEGVQYLHERNIVHLDLKPQNILLtseFPLGDIKLCDFGISRVIGEGEEIREILGTPDYVAPEILS----- 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 152 gtgY---SFEVDWWSVGVMAYELLRGWRPYdihssnAVESLVQLF---STVSVQYVP-TW---SKEMVALLRKLLTVNPE 221
Cdd:cd14106  184 ---YepiSLATDMWSIGVLTYVLLTGHSPF------GGDDKQETFlniSQCNLDFPEeLFkdvSPLAIDFIKRLLVKDPE 254

                 ..
gi 247269852 222 HR 223
Cdd:cd14106  255 KR 256
pk1 PHA03390
serine/threonine-protein kinase 1; Provisional
22-181 3.30e-22

serine/threonine-protein kinase 1; Provisional


Pssm-ID: 223069 [Multi-domain]  Cd Length: 267  Bit Score: 94.54  E-value: 3.30e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  22 FRELEILQEI---EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHR 98
Cdd:PHA03390  54 FNAIEPMVHQlmkDNPNFIKLYYSVTTLKGHVLIMDYIKDGDLFDLLKKEGKLSEAEVKKIIRQLVEALNDLHKHNIIHN 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  99 DVKPDNILLDE-QGHAHLTDFNIATIIKdgeRATALAGTKPYMAPE-IFHSFvnggtgYSFEVDWWSVGVMAYELLRGWR 176
Cdd:PHA03390 134 DIKLENVLYDRaKDRIYLCDYGLCKIIG---TPSCYDGTLDYFSPEkIKGHN------YDVSFDWWAVGVLTYELLTGKH 204

                 ....*
gi 247269852 177 PYDIH 181
Cdd:PHA03390 205 PFKED 209
STKc_CaMKI_beta cd14169
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
11-231 3.39e-22

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-beta subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271071 [Multi-domain]  Cd Length: 277  Bit Score: 94.96  E-value: 3.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  11 QCIERDEVRN----VFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALA 86
Cdd:cd14169   34 KCIPKKALRGkeamVENEIAVLRRINHENIVSLEDIYESPTHLYLAMELVTGGELFDRIIERGSYTEKDASQLIGQVLQA 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  87 LDYLRSQHIIHRDVKPDNILLD---EQGHAHLTDFNIATIIKDGERATAlAGTKPYMAPEIFHSfvnggTGYSFEVDWWS 163
Cdd:cd14169  114 VKYLHQLGIVHRDLKPENLLYAtpfEDSKIMISDFGLSKIEAQGMLSTA-CGTPGYVAPELLEQ-----KPYGKAVDVWA 187
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 164 VGVMAYELLRGWRP-YDihssnavESLVQLFSTV-SVQY---VPTW---SKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd14169  188 IGVISYILLCGYPPfYD-------ENDSELFNQIlKAEYefdSPYWddiSESAKDFIRHLLERDPEKRFTCEQALQ 256
STKc_MSK_C cd14092
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
20-225 3.55e-22

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, in response to various stimuli such as growth factors, hormones, neurotransmitters, cellular stress, and pro-inflammatory cytokines. This triggers phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) in the C-terminal extension of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. MSKs are predominantly nuclear proteins. They are widely expressed in many tissues including heart, brain, lung, liver, kidney, and pancreas. There are two isoforms of MSK, called MSK1 and MSK2. The MSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270994 [Multi-domain]  Cd Length: 311  Bit Score: 95.44  E-value: 3.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  20 NVFRELEILQEIE-HVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHR 98
Cdd:cd14092   44 DTSREVQLLRLCQgHPNIVKLHEVFQDELHTYLVMELLRGGELLERIRKKKRFTESEASRIMRQLVSAVSFMHSKGVVHR 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  99 DVKPDNILL---DEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFhSFVNGGTGYSFEVDWWSVGVMAYELLRGW 175
Cdd:cd14092  124 DLKPENLLFtdeDDDAEIKIVDFGFARLKPENQPLKTPCFTLPYAAPEVL-KQALSTQGYDESCDLWSLGVILYTMLSGQ 202
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 176 RPYDIHSSNA-VESLVQL-------FSTVSVQYVPTWSKEmvaLLRKLLTVNPEHRFS 225
Cdd:cd14092  203 VPFQSPSRNEsAAEIMKRiksgdfsFDGEEWKNVSSEAKS---LIQGLLTVDPSKRLT 257
STKc_IKK cd13989
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
58-182 5.00e-22

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The IKK complex functions as a master regulator of Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. It is composed of two kinases, IKKalpha and IKKbeta, and the regulatory subunit IKKgamma or NEMO (NF-kB Essential MOdulator). IKKs facilitate the release of NF-kB dimers from an inactive state, allowing them to migrate to the nucleus where they regulate gene transcription. There are two IKK pathways that regulate NF-kB signaling, called the classical (involving IKKbeta and NEMO) and non-canonical (involving IKKalpha) pathways. The classical pathway regulates the majority of genes activated by NF-kB. The IKK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270891 [Multi-domain]  Cd Length: 289  Bit Score: 94.44  E-value: 5.00e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  58 GGDLRYHLQQNVQFS---EDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHA---HLTDFNIATIIKDGERAT 131
Cdd:cd13989   83 GGDLRKVLNQPENCCglkESEVRTLLSDISSAISYLHENRIIHRDLKPENIVLQQGGGRviyKLIDLGYAKELDQGSLCT 162
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 247269852 132 ALAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELLRGWRPYDIHS 182
Cdd:cd13989  163 SFVGTLQYLAPELFES-----KKYTCTVDYWSFGTLAFECITGYRPFLPNW 208
STKc_IRAK cd14066
Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases ...
2-193 5.30e-22

Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. Some IRAKs may also play roles in T- and B-cell signaling, and adaptive immunity. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK-1, -2, and -4 are ubiquitously expressed and are active kinases, while IRAK-M is only induced in monocytes and macrophages and is an inactive kinase. Variations in IRAK genes are linked to diverse diseases including infection, sepsis, cancer, and autoimmune diseases. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain (a pseudokinase domain in the case of IRAK3), and a C-terminal domain; IRAK-4 lacks the C-terminal domain. This subfamily includes plant receptor-like kinases (RLKs) including Arabidopsis thaliana BAK1 and CLAVATA1 (CLV1). BAK1 functions in BR (brassinosteroid)-regulated plant development and in pathways involved in plant resistance to pathogen infection and herbivore attack. CLV1, directly binds small signaling peptides, CLAVATA3 (CLV3) and CLAVATA3/EMBRYO SURROUNDING REGI0N (CLE), to restrict stem cell proliferation: the CLV3-CLV1-WUS (WUSCHEL) module influences stem cell maintenance in the shoot apical meristem, and the CLE40 (CLAVATA3/EMBRYO SURROUNDING REGION40) -ACR4 (CRINKLY4) -CLV1- WOX5 (WUSCHEL-RELATED HOMEOBOX5) module at the root apical meristem. The IRAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270968 [Multi-domain]  Cd Length: 272  Bit Score: 94.26  E-value: 5.30e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVrnvF-RELEILQEIEHVFLVNLW-YSFQDEEdMFMVVDLLLGGDLRYHLqqNVQFSED----T 75
Cdd:cd14066   20 VAVKRLNEMNCAASKKE---FlTELEMLGRLRHPNLVRLLgYCLESDE-KLLVYEYMPNGSLEDRL--HCHKGSPplpwP 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  76 VRLYIC-EMALALDYL---RSQHIIHRDVKPDNILLDEQGHAHLTDFNIATII---KDGERATALAGTKPYMAPEifhsF 148
Cdd:cd14066   94 QRLKIAkGIARGLEYLheeCPPPIIHGDIKSSNILLDEDFEPKLTDFGLARLIppsESVSKTSAVKGTIGYLAPE----Y 169
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 247269852 149 VNGGTgYSFEVDWWSVGVMAYELLRGWRPYDIHSSNA-VESLVQLF 193
Cdd:cd14066  170 IRTGR-VSTKSDVYSFGVVLLELLTGKPAVDENRENAsRKDLVEWV 214
PTZ00267 PTZ00267
NIMA-related protein kinase; Provisional
24-232 6.45e-22

NIMA-related protein kinase; Provisional


Pssm-ID: 140293 [Multi-domain]  Cd Length: 478  Bit Score: 96.62  E-value: 6.45e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  24 ELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQ----FSEDTVRLYICEMALALDYLRSQHIIHRD 99
Cdd:PTZ00267 115 ELHCLAACDHFGIVKHFDDFKSDDKLLLIMEYGSGGDLNKQIKQRLKehlpFQEYEVGLLFYQIVLALDEVHSRKMMHRD 194
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 100 VKPDNILLDEQGHAHLTDFNIATIIKDG---ERATALAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELLRGWR 176
Cdd:PTZ00267 195 LKSANIFLMPTGIIKLGDFGFSKQYSDSvslDVASSFCGTPYYLAPELWER-----KRYSKKADMWSLGVILYELLTLHR 269
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 177 PYDIHSSNAVESLVqLFSTVSVQYVPTwSKEMVALLRKLLTVNPEHRFSSLQDMQT 232
Cdd:PTZ00267 270 PFKGPSQREIMQQV-LYGKYDPFPCPV-SSGMKALLDPLLSKNPALRPTTQQLLHT 323
STKc_NAK1_like cd06917
Catalytic domain of Fungal Nak1-like Serine/Threonine Kinases; STKs catalyze the transfer of ...
2-226 6.51e-22

Catalytic domain of Fungal Nak1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Nak1, Saccharomyces cerevisiae Kic1p (kinase that interacts with Cdc31p) and related proteins. Nak1 (also called N-rich kinase 1), is required by fission yeast for polarizing the tips of actin cytoskeleton and is involved in cell growth, cell separation, cell morphology and cell-cycle progression. Kic1p is required by budding yeast for cell integrity and morphogenesis. Kic1p interacts with Cdc31p, the yeast homologue of centrin, and phosphorylates substrates in a Cdc31p-dependent manner. The Nak1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270822 [Multi-domain]  Cd Length: 277  Bit Score: 94.08  E-value: 6.51e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQciERDEVRNVFRELEILQEIEHVFLVNL---WYSFQDEEDMFMVVDLLLGGDLRyHLQQNVQFSEDTVRL 78
Cdd:cd06917   29 VALKVLNLDT--DDDDVSDIQKEVALLSQLKLGQPKNIikyYGSYLKGPSLWIIMDYCEGGSIR-TLMRAGPIAERYIAV 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAT--IIKDGERATaLAGTKPYMAPEIfhsfVNGGTGYS 156
Cdd:cd06917  106 IMREVLVALKFIHKDGIIHRDIKAANILVTNTGNVKLCDFGVAAslNQNSSKRST-FVGTPYWMAPEV----ITEGKYYD 180
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 247269852 157 FEVDWWSVGVMAYELLRGWRPYDIHSSNAVeslVQLFSTVSVQYVP--TWSKEMVALLRKLLTVNPEHRFSS 226
Cdd:cd06917  181 TKADIWSLGITTYEMATGNPPYSDVDALRA---VMLIPKSKPPRLEgnGYSPLLKEFVAACLDEEPKDRLSA 249
TyrKc smart00219
Tyrosine kinase, catalytic domain; Phosphotransferases. Tyrosine-specific kinase subfamily.
3-229 6.55e-22

Tyrosine kinase, catalytic domain; Phosphotransferases. Tyrosine-specific kinase subfamily.


Pssm-ID: 197581 [Multi-domain]  Cd Length: 257  Bit Score: 93.36  E-value: 6.55e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852     3 AMKYMNKqqCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQN-VQFSEDTVRLYIC 81
Cdd:smart00219  32 AVKTLKE--DASEQQIEEFLREARIMRKLDHPNVVKLLGVCTEEEPLYIVMEYMEGGDLLSYLRKNrPKLSLSDLLSFAL 109
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852    82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPY--MAPEIFHSFVnggtgYSFEV 159
Cdd:smart00219 110 QIARGMEYLESKNFIHRDLAARNCLVGENLVVKISDFGLSRDLYDDDYYRKRGGKLPIrwMAPESLKEGK-----FTSKS 184
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852   160 DWWSVGVMAYELL-RGWRPYDIHSSNAVESLVQ----LFStvsvqyVPTWSKEMVALLRKLLTVNPEHR--FSSLQD 229
Cdd:smart00219 185 DVWSFGVLLWEIFtLGEQPYPGMSNEEVLEYLKngyrLPQ------PPNCPPELYDLMLQCWAEDPEDRptFSELVE 255
STKc_MEKK3_like cd06625
Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) ...
3-228 6.62e-22

Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MEKK3, MEKK2, and related proteins; all contain an N-terminal PB1 domain, which mediates oligomerization, and a C-terminal catalytic domain. MEKK2 and MEKK3 are MAPK kinase kinases (MAPKKKs or MKKK) that activate MEK5 (also called MKK5), which activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. MEKK2 and MEKK3 can also activate the MAPKs, c-Jun N-terminal kinase (JNK) and p38, through their respective MAPKKs. The MEKK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270795 [Multi-domain]  Cd Length: 260  Bit Score: 93.57  E-value: 6.62e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQ--CIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd06625   29 AVKQVEIDPinTEASKEVKALECEIQLLKNLQHERIVQYYGCLQDEKSLSIFMEYMPGGSVKDEIKAYGALTENVTRKYT 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAT---IIKDGERATALAGTKPYMAPEIfhsfVNgGTGYSF 157
Cdd:cd06625  109 RQILEGLAYLHSNMIVHRDIKGANILRDSNGNVKLGDFGASKrlqTICSSTGMKSVTGTPYWMSPEV----IN-GEGYGR 183
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 247269852 158 EVDWWSVGVMAYELLRGWRPYdihssNAVESLVQLFSTVSVQYVPTW----SKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd06625  184 KADIWSVGCTVVEMLTTKPPW-----AEFEPMAAIFKIATQPTNPQLpphvSEDARDFLSLIFVRNKKQRPSAEE 253
STKc_MAPK cd07834
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase; STKs ...
21-274 1.07e-21

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation, proliferation, migration, and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer, stroke, diabetes, and chronic inflammation. Typical MAPK pathways involve a triple kinase core cascade comprising of the MAPK, which is phosphorylated and activated by a MAPK kinase (MAP2K or MKK), which itself is phosphorylated and activated by a MAPK kinase kinase (MAP3K or MKKK). Each cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. There are three typical MAPK subfamilies: Extracellular signal-Regulated Kinase (ERK), c-Jun N-terminal Kinase (JNK), and p38. Some MAPKs are atypical in that they are not regulated by MAP2Ks. These include MAPK4, MAPK6, NLK, and ERK7. The MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270828 [Multi-domain]  Cd Length: 329  Bit Score: 94.51  E-value: 1.07e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  21 VFRELEILQEIEH---VFLVNLWYSFQ--DEEDMFMVVDLLlGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHI 95
Cdd:cd07834   46 ILREIKILRHLKHeniIGLLDILRPPSpeEFNDVYIVTELM-ETDLHKVIKSPQPLTDDHIQYFLYQILRGLKYLHSAGV 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  96 IHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAG---TKPYMAPEIfhsfVNGGTGYSFEVDWWSVG-VMAyEL 171
Cdd:cd07834  125 IHRDLKPSNILVNSNCDLKICDFGLARGVDPDEDKGFLTEyvvTRWYRAPEL----LLSSKKYTKAIDIWSVGcIFA-EL 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 172 LRGwRPY--------------------------DIHSSNAVESLVQLFSTVSV---QYVPTWSKEMVALLRKLLTVNPEH 222
Cdd:cd07834  200 LTR-KPLfpgrdyidqlnlivevlgtpseedlkFISSEKARNYLKSLPKKPKKplsEVFPGASPEAIDLLEKMLVFNPKK 278
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 223 RFSSLQdmqtapSLAHVLWDDLSEKKVEPGFVPN---KGRLHCDPTFE-LEEMILE 274
Cdd:cd07834  279 RITADE------ALAHPYLAQLHDPEDEPVAKPPfdfPFFDDEELTIEeLKELIYE 328
PKc_MKK4 cd06616
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
64-231 1.34e-21

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK4 is a dual-specificity PK that phosphorylates and activates the downstream targets, c-Jun N-terminal kinase (JNK) and p38 MAPK, on specific threonine and tyrosine residues. JNK and p38 are collectively known as stress-activated MAPKs, as they are activated in response to a variety of environmental stresses and pro-inflammatory cytokines. Their activation is associated with the induction of cell death. Mice deficient in MKK4 die during embryogenesis and display anemia, severe liver hemorrhage, and abnormal hepatogenesis. MKK4 may also play roles in the immune system and in cardiac hypertrophy. It plays a major role in cancer as a tumor and metastasis suppressor. Under certain conditions, MKK4 is pro-oncogenic. The MKK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270790 [Multi-domain]  Cd Length: 291  Bit Score: 93.58  E-value: 1.34e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  64 HLQQNVQFSED--------TVRlyicemalALDYLRSQ-HIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALA 134
Cdd:cd06616   99 YEVLDSVIPEEilgkiavaTVK--------ALNYLKEElKIIHRDVKPSNILLDRNGNIKLCDFGISGQLVDSIAKTRDA 170
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 135 GTKPYMAPEIFHSFvNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSnAVESLVQLFSTVSVQYVPT----WSKEMVA 210
Cdd:cd06616  171 GCRPYMAPERIDPS-ASRDGYDVRSDVWSLGITLYEVATGKFPYPKWNS-VFDQLTQVVKGDPPILSNSeereFSPSFVN 248
                        170       180
                 ....*....|....*....|...
gi 247269852 211 LLRKLLTVNPEHR--FSSLQDMQ 231
Cdd:cd06616  249 FVNLCLIKDESKRpkYKELLKHP 271
STYKc smart00221
Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class ...
3-229 1.51e-21

Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase.


Pssm-ID: 214568 [Multi-domain]  Cd Length: 258  Bit Score: 92.61  E-value: 1.51e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852     3 AMKYMNKqqCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQN--VQFSEDTVRLYI 80
Cdd:smart00221  32 AVKTLKE--DASEQQIEEFLREARIMRKLDHPNIVKLLGVCTEEEPLMIVMEYMPGGDLLDYLRKNrpKELSLSDLLSFA 109
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852    81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPY--MAPEIFHSFVnggtgYSFE 158
Cdd:smart00221 110 LQIARGMEYLESKNFIHRDLAARNCLVGENLVVKISDFGLSRDLYDDDYYKVKGGKLPIrwMAPESLKEGK-----FTSK 184
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852   159 VDWWSVGVMAYELL-RGWRPYDIHSSNAVESLVQ----LFStvsvqyVPTWSKEMVALLRKLLTVNPEHR--FSSLQD 229
Cdd:smart00221 185 SDVWSFGVLLWEIFtLGEEPYPGMSNAEVLEYLKkgyrLPK------PPNCPPELYKLMLQCWAEDPEDRptFSELVE 256
STKc_Trio_C cd14113
C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide ...
3-178 1.64e-21

C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Triple functional domain protein (Trio), also called PTPRF-interacting protein, is a large multidomain protein containing a series of spectrin-like repeats, two each of RhoGEF and SH3 domains, an immunoglobulin-like (Ig) domain and a C-terminal kinase. Trio plays important roles in neuronal cell migration and axon guidance. It was originally identified as an interacting partner of the of the receptor-like tyrosine phosphatase (RPTP) LAR (leukocyte-antigen-related protein), a family of receptors that function in the signaling to the actin cytoskeleton during development. Trio functions as a GEF for Rac1, RhoG, and RhoA, and is involved in the regulation of lamellipodia formation, mediating Rac1-dependent cell spreading and migration. The Trio subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271015 [Multi-domain]  Cd Length: 263  Bit Score: 92.73  E-value: 1.64e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQqCIERDEVRNvfrELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICE 82
Cdd:cd14113   36 ATKFVNKK-LMKRDQVTH---ELGVLQSLQHPQLVGLLDTFETPTSYILVLEMADQGRLLDYVVRWGNLTEEKIRFYLRE 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQHIIHRDVKPDNILLDE---QGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFEV 159
Cdd:cd14113  112 ILEALQYLHNCRIAHLDLKPENILVDQslsKPTIKLADFGDAVQLNTTYYIHQLLGSPEFAAPEIIL-----GNPVSLTS 186
                        170
                 ....*....|....*....
gi 247269852 160 DWWSVGVMAYELLRGWRPY 178
Cdd:cd14113  187 DLWSIGVLTYVLLSGVSPF 205
STKc_CASK cd14094
Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein ...
23-228 1.64e-21

Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CASK belongs to the MAGUK (membrane-associated guanylate kinase) protein family, which functions as multiple domain adaptor proteins and is characterized by the presence of a core of three domains: PDZ, SH3, and guanylate kinase (GuK). The enzymatically inactive GuK domain in MAGUK proteins mediates protein-protein interactions and associates intramolecularly with the SH3 domain. In addition, CASK contains a catalytic kinase and two L27 domains. It is highly expressed in the nervous system and plays roles in synaptic protein targeting, neural development, and regulation of gene expression. Binding partners include parkin (a Parkinson's disease molecule), neurexin (adhesion molecule), syndecans, calcium channel proteins, CINAP (nucleosome assembly protein), transcription factor Tbr-1, and the cytoplasmic adaptor proteins Mint1, Veli/mLIN-7/MALS, SAP97, caskin, and CIP98. Deletion or mutations in the CASK gene have been implicated in X-linked mental retardation. The CASK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270996 [Multi-domain]  Cd Length: 300  Bit Score: 93.38  E-value: 1.64e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQ----FSEDTVRLYICEMALALDYLRSQHIIHR 98
Cdd:cd14094   54 REASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADagfvYSEAVASHYMRQILEALRYCHDNNIIHR 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  99 DVKPDNILL---DEQGHAHLTDFNIATIIKD-GERATALAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELLRG 174
Cdd:cd14094  134 DVKPHCVLLaskENSAPVKLGGFGVAIQLGEsGLVAGGRVGTPHFMAPEVVKR-----EPYGKPVDVWGCGVILFILLSG 208
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 247269852 175 WRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd14094  209 CLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYE 262
STKc_SLK_like cd06611
Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases; STKs catalyze the ...
14-249 2.25e-21

Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of the subfamily include SLK, STK10 (also called LOK for Lymphocyte-Oriented Kinase), SmSLK (Schistosoma mansoni SLK), and related proteins. SLK promotes apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and the mitogen-activated protein kinase (MAPK) p38. It also plays a role in mediating actin reorganization. STK10 is responsible in regulating the CD28 responsive element in T cells, as well as leukocyte function associated antigen (LFA-1)-mediated lymphocyte adhesion. SmSLK is capable of activating the MAPK Jun N-terminal kinase (JNK) pathway in human embryonic kidney cells as well as in Xenopus oocytes. It may participate in regulating MAPK cascades during host-parasite interactions. The SLK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132942 [Multi-domain]  Cd Length: 280  Bit Score: 92.50  E-value: 2.25e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  14 ERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDL-RYHLQQNVQFSEDTVRlYIC-EMALALDYLR 91
Cdd:cd06611   42 SEEELEDFMVEIDILSECKHPNIVGLYEAYFYENKLWILIEFCDGGALdSIMLELERGLTEPQIR-YVCrQMLEALNFLH 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  92 SQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDG-ERATALAGTKPYMAPEIFHSFVNGGTGYSFEVDWWSVGVMAYE 170
Cdd:cd06611  121 SHKVIHRDLKAGNILLTLDGDVKLADFGVSAKNKSTlQKRDTFIGTPYWMAPEVVACETFKDNPYDYKADIWSLGITLIE 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 171 LLRGWRPYdiHSSNAVESLVQLFSTVSvqyvPT------WSKEMVALLRKLLTVNPEHRFSSLQDMQtapslaHVLWDDL 244
Cdd:cd06611  201 LAQMEPPH--HELNPMRVLLKILKSEP----PTldqpskWSSSFNDFLKSCLVKDPDDRPTAAELLK------HPFVSDQ 268

                 ....*
gi 247269852 245 SEKKV 249
Cdd:cd06611  269 SDNKA 273
STKc_RSK_C cd14091
C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases; STKs ...
2-231 2.47e-21

C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. Mammals possess four RSK isoforms (RSK1-4) from distinct genes. RSK proteins are also referred to as MAP kinase-activated protein kinases (MAPKAPKs), 90 kDa ribosomal protein S6 kinases (p90-RSKs), or p90S6Ks. The RSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270993 [Multi-domain]  Cd Length: 291  Bit Score: 92.70  E-value: 2.47e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVrnvfrelEILQEI-EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14091   28 YAVKIIDKSKRDPSEEI-------EILLRYgQHPNIITLRDVYDDGNSVYLVTELLRGGELLDRILRQKFFSEREASAVM 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILL-DEQGHA---HLTDFNIAtiikdgERATALAG-------TKPYMAPEIFHSfv 149
Cdd:cd14091  101 KTLTKTVEYLHSQGVVHRDLKPSNILYaDESGDPeslRICDFGFA------KQLRAENGllmtpcyTANFVAPEVLKK-- 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 150 nggTGYSFEVDWWSVGVMAYELLRGWRPYdihSSNAVESLVQLFSTVSVQYV----PTW---SKEMVALLRKLLTVNPEH 222
Cdd:cd14091  173 ---QGYDAACDIWSLGVLLYTMLAGYTPF---ASGPNDTPEVILARIGSGKIdlsgGNWdhvSDSAKDLVRKMLHVDPSQ 246

                 ....*....
gi 247269852 223 RFSSLQDMQ 231
Cdd:cd14091  247 RPTAAQVLQ 255
STKc_MLCK4 cd14193
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4; STKs catalyze ...
3-178 2.66e-21

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. In vertebrates, different MLCKs function in smooth (MLCK1), skeletal (MLCK2), and cardiac (MLCK3) muscles. A fourth protein, MLCK4, has also been identified through comprehensive genome analysis although it has not been biochemically characterized. MLCK4 (or MYLK4 or SgK085) contains a single kinase domain near the C-terminus. The MLCK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271095 [Multi-domain]  Cd Length: 261  Bit Score: 91.90  E-value: 2.66e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNvfrELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL-QQNVQFSEDTVRLYIC 81
Cdd:cd14193   33 AAKIIKARSQKEKEEVKN---EIEVMNQLNHANLIQLYDAFESRNDIVLVMEYVDGGELFDRIiDENYNLTELDTILFIK 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILL--DEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIF-HSFVnggtgySFE 158
Cdd:cd14193  110 QICEGIQYMHQMYILHLDLKPENILCvsREANQVKIIDFGLARRYKPREKLRVNFGTPEFLAPEVVnYEFV------SFP 183
                        170       180
                 ....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPY 178
Cdd:cd14193  184 TDMWSLGVIAYMLLSGLSPF 203
STKc_Nek6_7 cd08224
Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related ...
9-171 4.17e-21

Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek6 and Nek7 are the shortest Neks, consisting only of the catalytic domain and a very short N-terminal extension. They show distinct expression patterns and both appear to be downstream substrates of Nek9. They are required for mitotic spindle formation and cytokinesis. They may also be regulators of the p70 ribosomal S6 kinase. Nek6/7 is part of a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270863 [Multi-domain]  Cd Length: 262  Bit Score: 91.56  E-value: 4.17e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   9 KQQCIerdevrnvfRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDL----RYHLQQNVQFSEDTVRLYICEMA 84
Cdd:cd08224   44 RQDCL---------KEIDLLQQLNHPNIIKYLASFIENNELNIVLELADAGDLsrliKHFKKQKRLIPERTIWKYFVQLC 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  85 LALDYLRSQHIIHRDVKPDNILLDEQGHAHLTD------FNIATIIkdgerATALAGTKPYMAPEIFHsfvngGTGYSFE 158
Cdd:cd08224  115 SALEHMHSKRIMHRDIKPANVFITANGVVKLGDlglgrfFSSKTTA-----AHSLVGTPYYMSPERIR-----EQGYDFK 184
                        170
                 ....*....|...
gi 247269852 159 VDWWSVGVMAYEL 171
Cdd:cd08224  185 SDIWSLGCLLYEM 197
STKc_Byr2_like cd06628
Catalytic domain of the Serine/Threonine Kinases, fungal Byr2-like Mitogen-Activated Protein ...
23-222 4.32e-21

Catalytic domain of the Serine/Threonine Kinases, fungal Byr2-like Mitogen-Activated Protein Kinase Kinase Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include the MAPKKKs Schizosaccharomyces pombe Byr2, Saccharomyces cerevisiae and Cryptococcus neoformans Ste11, and related proteins. They contain an N-terminal SAM (sterile alpha-motif) domain, which mediates protein-protein interaction, and a C-terminal catalytic domain. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Fission yeast Byr2 is regulated by Ras1. It responds to pheromone signaling and controls mating through the MAPK pathway. Budding yeast Ste11 functions in MAPK cascades that regulate mating, high osmolarity glycerol, and filamentous growth responses. The Byr2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270798 [Multi-domain]  Cd Length: 267  Bit Score: 91.44  E-value: 4.32e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKP 102
Cdd:cd06628   55 REIALLRELQHENIVQYLGSSSDANHLNIFLEYVPGGSVATLLNNYGAFEESLVRNFVRQILKGLNYLHNRGIIHRDIKG 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 103 DNILLDEQGHAHLTDFNIATIIKDGERATALAGTKP-------YMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELLRGW 175
Cdd:cd06628  135 ANILVDNKGGIKISDFGISKKLEANSLSTKNNGARPslqgsvfWMAPEVVKQ-----TSYTRKADIWSLGCLVVEMLTGT 209
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 247269852 176 RPYDihSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKllTVNPEH 222
Cdd:cd06628  210 HPFP--DCTQMQAIFKIGENASPTIPSNISSEARDFLEK--TFEIDH 252
STKc_PAK3 cd06656
Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3; Serine ...
3-178 4.77e-21

Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3; Serine/threonine kinases (STKs), p21-activated kinase (PAK) 3, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs from higher eukaryotes are classified into two groups (I and II), according to their biochemical and structural features. PAK3 belongs to group I. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAK3 is highly expressed in the brain. It is implicated in neuronal plasticity, synapse formation, dendritic spine morphogenesis, cell cycle progression, neuronal migration, and apoptosis. Inactivating mutations in the PAK3 gene cause X-linked non-syndromic mental retardation, the severity of which depends on the site of the mutation.


Pssm-ID: 132987 [Multi-domain]  Cd Length: 297  Bit Score: 92.09  E-value: 4.77e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNvfrELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVqFSEDTVRLYICE 82
Cdd:cd06656   48 AIKQMNLQQQPKKELIIN---EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRE 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNI-ATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEVDW 161
Cdd:cd06656  124 CLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPEQSKRSTMVGTPYWMAPEVVTR-----KAYGPKVDI 198
                        170
                 ....*....|....*..
gi 247269852 162 WSVGVMAYELLRGWRPY 178
Cdd:cd06656  199 WSLGIMAIEMVEGEPPY 215
STKc_GAK_like cd13985
Catalytic domain of cyclin G-Associated Kinase-like proteins; STKs catalyze the transfer of ...
2-231 5.41e-21

Catalytic domain of cyclin G-Associated Kinase-like proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes cyclin G-Associated Kinase (GAK), Drosophila melanogaster Numb-Associated Kinase (NAK)-like proteins, and similar protein kinases. GAK plays regulatory roles in clathrin-mediated membrane trafficking, the maintenance of centrosome integrity and chromosome congression, neural patterning, survival of neurons, and immune responses. NAK plays a role in asymmetric cell division through its association with Numb. It also regulates the localization of Dlg, a protein essential for septate junction formation. The GAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270887 [Multi-domain]  Cd Length: 272  Bit Score: 91.24  E-value: 5.41e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNkqqCIERDEVRNVFRELEILQEIE-HVFLVNLWYS--FQDE--EDMFMVVDLLlGGDLrYHLQQNV---QFSE 73
Cdd:cd13985   28 YALKRMY---FNDEEQLRVAIKEIEIMKRLCgHPNIVQYYDSaiLSSEgrKEVLLLMEYC-PGSL-VDILEKSppsPLSE 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  74 DTVRLYICEMALALDYLRSQH--IIHRDVKPDNILLDEQGHAHLTDF--------------NIATIIKDGERATALAgtk 137
Cdd:cd13985  103 EEVLRIFYQICQAVGHLHSQSppIIHRDIKIENILFSNTGRFKLCDFgsattehypleraeEVNIIEEEIQKNTTPM--- 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 138 pYMAPEIFHSFVNGGTGYsfEVDWWSVGVMAYELLrgwrpYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLT 217
Cdd:cd13985  180 -YRAPEMIDLYSKKPIGE--KADIWALGCLLYKLC-----FFKLPFDESSKLAIVAGKYSIPEQPRYSPELHDLIRHMLT 251
                        250
                 ....*....|....
gi 247269852 218 VNPEHRFSSLQDMQ 231
Cdd:cd13985  252 PDPAERPDIFQVIN 265
STKc_PAK2 cd06655
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2; STKs catalyze the ...
3-231 7.38e-21

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK2 plays a role in pro-apoptotic signaling. It is cleaved and activated by caspases leading to morphological changes during apoptosis. PAK2 is also activated in response to a variety of stresses including DNA damage, hyperosmolarity, serum starvation, and contact inhibition, and may play a role in coordinating the stress response. PAK2 also contributes to cancer cell invasion through a mechanism distinct from that of PAK1. It belongs to the group I PAKs, which contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132986 [Multi-domain]  Cd Length: 296  Bit Score: 91.32  E-value: 7.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNvfrELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVqFSEDTVRLYICE 82
Cdd:cd06655   48 AIKQINLQKQPKKELIIN---EILVMKELKNPNIVNFLDSFLVGDELFVVMEYLAGGSLTDVVTETC-MDEAQIAAVCRE 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNI-ATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEVDW 161
Cdd:cd06655  124 CLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFcAQITPEQSKRSTMVGTPYWMAPEVVTR-----KAYGPKVDI 198
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 162 WSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd06655  199 WSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQ 268
STKc_IKK_beta cd14038
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
10-178 7.60e-21

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IKKbeta is involved in the classical pathway of regulating Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. The classical pathway regulates the majority of genes activated by NF-kB including those encoding cytokines, chemokines, leukocyte adhesion molecules, and anti-apoptotic factors. It involves NEMO (NF-kB Essential MOdulator)- and IKKbeta-dependent phosphorylation and degradation of the Inhibitor of NF-kB (IkB), which liberates NF-kB dimers (typified by the p50-p65 heterodimer) from an inactive IkB/dimeric NF-kB complex, enabling them to migrate to the nucleus where they regulate gene transcription. The IKKbeta subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270940 [Multi-domain]  Cd Length: 290  Bit Score: 91.18  E-value: 7.60e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  10 QQCIERDEVRNVFR---ELEILQEIEHVFLVNLwYSFQDEEDMFMVVDLLL-------GGDLRYHLQQ---NVQFSEDTV 76
Cdd:cd14038   25 KQCRQELSPKNRERwclEIQIMKRLNHPNVVAA-RDVPEGLQKLAPNDLPLlameycqGGDLRKYLNQfenCCGLREGAI 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  77 RLYICEMALALDYLRSQHIIHRDVKPDNILLdEQGHAHLT----DFNIATIIKDGERATALAGTKPYMAPEIFHSfvngg 152
Cdd:cd14038  104 LTLLSDISSALRYLHENRIIHRDLKPENIVL-QQGEQRLIhkiiDLGYAKELDQGSLCTSFVGTLQYLAPELLEQ----- 177
                        170       180
                 ....*....|....*....|....*.
gi 247269852 153 TGYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd14038  178 QKYTVTVDYWSFGTLAFECITGFRPF 203
STKc_PAK1 cd06654
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1; STKs catalyze the ...
3-231 1.34e-20

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK1 is important in the regulation of many cellular processes including cytoskeletal dynamics, cell motility, growth, and proliferation. Although PAK1 has been regarded mainly as a cytosolic protein, recent reports indicate that PAK1 also exists in significant amounts in the nucleus, where it is involved in transcription modulation and in cell cycle regulatory events. PAK1 is also involved in transformation and tumorigenesis. Its overexpression, hyperactivation and increased nuclear accumulation is correlated to breast cancer invasiveness and progression. Nuclear accumulation is also linked to tamoxifen resistance in breast cancer cells. PAK1 belongs to the group I PAKs, which contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270820 [Multi-domain]  Cd Length: 296  Bit Score: 90.94  E-value: 1.34e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNvfrELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVqFSEDTVRLYICE 82
Cdd:cd06654   49 AIRQMNLQQQPKKELIIN---EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRE 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNI-ATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEVDW 161
Cdd:cd06654  125 CLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFcAQITPEQSKRSTMVGTPYWMAPEVVTR-----KAYGPKVDI 199
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 162 WSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd06654  200 WSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ 269
STKc_Nek8 cd08220
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
14-223 1.73e-20

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek8 contains an N-terminal kinase catalytic domain and a C-terminal RCC1 (regulator of chromosome condensation) domain. A double point mutation in Nek8 causes cystic kidney disease in mice that genetically resembles human autosomal recessive polycystic kidney disease (ARPKD). Nek8 is also associated with a rare form of juvenile renal cystic disease, nephronophthisis type 9. It has been suggested that a defect in the ciliary localization of Nek8 contributes to the development of cysts manifested by these diseases. Nek8 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270859 [Multi-domain]  Cd Length: 256  Bit Score: 89.41  E-value: 1.73e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  14 ERDEVRNvfrELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ--NVQFSEDTVRLYICEMALALDYLR 91
Cdd:cd08220   42 ERQAALN---EVKVLSMLHHPNIIEYYESFLEDKALMIVMEYAPGGTLFEYIQQrkGSLLSEEEILHFFVQILLALHHVH 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  92 SQHIIHRDVKPDNILLDE-QGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYE 170
Cdd:cd08220  119 SKQILHRDLKTQNILLNKkRTVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCE-----GKPYNQKSDIWALGCVLYE 193
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 247269852 171 LLRGWRPYDihSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHR 223
Cdd:cd08220  194 LASLKRAFE--AANLPALVLKIMRGTFAPISDRYSEELRHLILSMLHLDPNKR 244
STKc_STK25 cd06642
Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1); ...
16-181 2.10e-20

Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK25 is also called Ste20/oxidant stress response kinase 1 (SOK1) or yeast Sps1/Ste20-related kinase 1 (YSK1). It is localized in the Golgi apparatus through its interaction with the Golgi matrix protein GM130. It may be involved in the regulation of cell migration and polarization. STK25 binds and phosphorylates CCM3 (cerebral cavernous malformation 3), also called PCD10 (programmed cell death 10), and may play a role in apoptosis. Human STK25 is a candidate gene responsible for pseudopseudohypoparathyroidism (PPHP), a disease that shares features with the Albright hereditary osteodystrophy (AHO) phenotype. The STK25 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270810 [Multi-domain]  Cd Length: 277  Bit Score: 89.73  E-value: 2.10e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  16 DEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHI 95
Cdd:cd06642   44 DEIEDIQQEITVLSQCDSPYITRYYGSYLKGTKLWIIMEYL-GGGSALDLLKPGPLEETYIATILREILKGLDYLHSERK 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  96 IHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE-RATALAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELLRG 174
Cdd:cd06642  123 IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQiKRNTFVGTPFWMAPEVIKQ-----SAYDFKADIWSLGITAIELAKG 197

                 ....*...
gi 247269852 175 WRPY-DIH 181
Cdd:cd06642  198 EPPNsDLH 205
STKc_CDK7 cd07841
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7; STKs ...
19-231 2.74e-20

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK7 plays essential roles in the cell cycle and in transcription. It associates with cyclin H and MAT1 and acts as a CDK-Activating Kinase (CAK) by phosphorylating and activating cell cycle CDKs (CDK1/2/4/6). In the brain, it activates CDK5. CDK7 is also a component of the general transcription factor TFIIH, which phosphorylates the C-terminal domain (CTD) of RNA polymerase II when it is bound with unphosphorylated DNA, as present in the pre-initiation complex. Following phosphorylation, the CTD dissociates from the DNA which allows transcription initiation. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270833 [Multi-domain]  Cd Length: 298  Bit Score: 89.94  E-value: 2.74e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  19 RNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQ-QNVQFSEDTVRLYICEMALALDYLRSQHIIH 97
Cdd:cd07841   47 FTALREIKLLQELKHPNIIGLLDVFGHKSNINLVFEFM-ETDLEKVIKdKSIVLTPADIKSYMLMTLRGLEYLHSNWILH 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  98 RDVKPDNILLDEQGHAHLTDFNIATIIKD-GERATALAGTKPYMAPEIFHsfvnGGTGYSFEVDWWSVGVMAYELLRGwR 176
Cdd:cd07841  126 RDLKPNNLLIASDGVLKLADFGLARSFGSpNRKMTHQVVTRWYRAPELLF----GARHYGVGVDMWSVGCIFAELLLR-V 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 177 PYdIHSSNAVESLVQLFSTVSV---------------------------QYVPTWSKEMVALLRKLLTVNPEHRFSSLQD 229
Cdd:cd07841  201 PF-LPGDSDIDQLGKIFEALGTpteenwpgvtslpdyvefkpfpptplkQIFPAASDDALDLLQRLLTLNPNKRITARQA 279

                 ..
gi 247269852 230 MQ 231
Cdd:cd07841  280 LE 281
STKc_CaMKI_delta cd14168
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
1-228 2.83e-20

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-delta subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271070 [Multi-domain]  Cd Length: 301  Bit Score: 90.11  E-value: 2.83e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEvrNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14168   37 LFAVKCIPKKALKGKES--SIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLI 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILL---DEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFhsfvnGGTGYSF 157
Cdd:cd14168  115 RQVLDAVYYLHRMGIVHRDLKPENLLYfsqDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVL-----AQKPYSK 189
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 247269852 158 EVDWWSVGVMAYELLRGWRP-YDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd14168  190 AVDCWSIGVIAYILLCGYPPfYDENDSKLFEQILKADYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQ 261
STKc_RSK3_C cd14178
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called ...
2-228 3.26e-20

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK3 is also called S6K-alpha-2, RPS6KA2, p90RSK2 or MAPK-activated protein kinase 1c (MAPKAPK-1c). RSK3 binds muscle A-kinase anchoring protein (mAKAP)-b directly and regulates concentric cardiac myocyte growth. The RSK3 gene, RPS6KA2, is a putative tumor suppressor gene in sporadic epithelial ovarian cancer and variations to the gene may be associated with rectal cancer risk. RSK3 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271080 [Multi-domain]  Cd Length: 293  Bit Score: 89.69  E-value: 3.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQcierdevRNVFRELEILQEI-EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14178   31 YAVKIIDKSK-------RDPSEEIEILLRYgQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQKCFSEREASAVL 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNIL-LDEQGHA---HLTDFNIATIIK--DGERATALAgTKPYMAPEIFHSfvnggTG 154
Cdd:cd14178  104 CTITKTVEYLHSQGVVHRDLKPSNILyMDESGNPesiRICDFGFAKQLRaeNGLLMTPCY-TANFVAPEVLKR-----QG 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 155 YSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLvqLFSTVSVQYVPT---W------SKEMVAllrKLLTVNPEHRFS 225
Cdd:cd14178  178 YDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEI--LARIGSGKYALSggnWdsisdaAKDIVS---KMLHVDPHQRLT 252

                 ...
gi 247269852 226 SLQ 228
Cdd:cd14178  253 APQ 255
PTZ00283 PTZ00283
serine/threonine protein kinase; Provisional
44-232 3.74e-20

serine/threonine protein kinase; Provisional


Pssm-ID: 240344 [Multi-domain]  Cd Length: 496  Bit Score: 91.47  E-value: 3.74e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  44 QDEED---MFMVVDLLLGGDLRYHLQQ----NVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLT 116
Cdd:PTZ00283 106 RNPENvlmIALVLDYANAGDLRQEIKSraktNRTFREHEAGLLFIQVLLAVHHVHSKHMIHRDIKSANILLCSNGLVKLG 185
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 117 DFNI-----ATIIKDGERatALAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVeslvq 191
Cdd:PTZ00283 186 DFGFskmyaATVSDDVGR--TFCGTPYYVAPEIWRR-----KPYSKKADMFSLGVLLYELLTLKRPFDGENMEEV----- 253
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 247269852 192 LFSTVSVQYVP---TWSKEMVALLRKLLTVNPEHRFSS--LQDMQT 232
Cdd:PTZ00283 254 MHKTLAGRYDPlppSISPEMQEIVTALLSSDPKRRPSSskLLNMPI 299
STKc_SPEG_rpt2 cd14111
Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle ...
6-229 4.20e-20

Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Striated muscle preferentially expressed gene (SPEG) generates 4 different isoforms through alternative promoter use and splicing in a tissue-specific manner: SPEGalpha and SPEGbeta are expressed in cardiac and skeletal striated muscle; Aortic Preferentially Expressed Protein-1 (APEG-1) is expressed in vascular smooth muscle; and Brain preferentially expressed gene (BPEG) is found in the brain and aorta. SPEG proteins have mutliple immunoglobulin (Ig), 2 fibronectin type III (FN3), and two kinase domains. They are necessary for cardiac development and survival. The SPEG subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271013 [Multi-domain]  Cd Length: 257  Bit Score: 88.73  E-value: 4.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   6 YMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMAL 85
Cdd:cd14111   31 FPAKIVPYQAEEKQGVLQEYEILKSLHHERIMALHEAYITPRYLVLIAEFCSGKELLHSLIDRFRYSEDDVVGYLVQILQ 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  86 ALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAT-----IIKDGERATalaGTKPYMAPEIFHSFVNGGTgysfeVD 160
Cdd:cd14111  111 GLEYLHGRRVLHLDIKPDNIMVTNLNAIKIVDFGSAQsfnplSLRQLGRRT---GTLEYMAPEMVKGEPVGPP-----AD 182
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 247269852 161 WWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRfSSLQD 229
Cdd:cd14111  183 IWSIGVLTYIMLSGRSPFEDQDPQETEAKILVAKFDAFKLYPNVSQSASLFLKKVLSSYPWSR-PTTKD 250
STKc_CDKL2_3 cd07846
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3; ...
14-231 5.03e-20

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKL2, also called p56 KKIAMRE, is expressed in testis, kidney, lung, and brain. It functions mainly in mature neurons and plays an important role in learning and memory. Inactivation of CDKL3, also called NKIAMRE (NKIATRE in rat), by translocation is associated with mild mental retardation. It has been reported that CDKL3 is lost in leukemic cells having a chromosome arm 5q deletion, and may contribute to the transformed phenotype. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270836 [Multi-domain]  Cd Length: 286  Bit Score: 89.02  E-value: 5.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  14 ERDEVRNV-FRELEILQEIEHVFLVNLWYSFQDEEDMFMV---VDLLLGGDLRYHLQQnvqFSEDTVRLYICEMALALDY 89
Cdd:cd07846   39 DDKMVKKIaMREIKMLKQLRHENLVNLIEVFRRKKRWYLVfefVDHTVLDDLEKYPNG---LDESRVRKYLFQILRGIDF 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  90 LRSQHIIHRDVKPDNILLDEQGHAHLTDFNIA-TIIKDGERATALAGTKPYMAPEIfhsfVNGGTGYSFEVDWWSVGVMA 168
Cdd:cd07846  116 CHSHNIIHRDIKPENILVSQSGVVKLCDFGFArTLAAPGEVYTDYVATRWYRAPEL----LVGDTKYGKAVDVWAVGCLV 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 169 YELLRGwRPY-----DI----HSSNAVESLVQ----------LFSTVSVQYV----------PTWSKEMVALLRKLLTVN 219
Cdd:cd07846  192 TEMLTG-EPLfpgdsDIdqlyHIIKCLGNLIPrhqelfqknpLFAGVRLPEVkeveplerryPKLSGVVIDLAKKCLHID 270
                        250
                 ....*....|..
gi 247269852 220 PEHRFSSLQDMQ 231
Cdd:cd07846  271 PDKRPSCSELLH 282
PKc_MKK3_6 cd06617
Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase ...
86-231 5.13e-20

Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK3 and MKK6 are dual-specificity PKs that phosphorylate and activate their downstream target, p38 MAPK, on specific threonine and tyrosine residues. MKK3/6 play roles in the regulation of cell cycle progression, cytokine- and stress-induced apoptosis, oncogenic transformation, and adult tissue regeneration. In addition, MKK6 plays a critical role in osteoclast survival in inflammatory disease while MKK3 is associated with tumor invasion, progression, and poor patient survival in glioma. The MKK3/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173729 [Multi-domain]  Cd Length: 283  Bit Score: 88.64  E-value: 5.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  86 ALDYLRSQ-HIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEifhsFVNGGT---GYSFEVDW 161
Cdd:cd06617  115 ALEYLHSKlSVIHRDVKPSNVLINRNGQVKLCDFGISGYLVDSVAKTIDAGCKPYMAPE----RINPELnqkGYDVKSDV 190
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 247269852 162 WSVGVMAYELLRGWRPYDiHSSNAVESLVQLFSTVSVQyVP--TWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd06617  191 WSLGITMIELATGRFPYD-SWKTPFQQLKQVVEEPSPQ-LPaeKFSPEFQDFVNKCLKKNYKERPNYPELLQ 260
STKc_MAK_like cd07830
Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; STKs ...
3-231 5.69e-20

Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of human MAK and MAK-related kinase (MRK), Saccharomyces cerevisiae Ime2p, Schizosaccharomyces pombe Mei4-dependent protein 3 (Mde3) and Pit1, Caenorhabditis elegans dyf-5, Arabidopsis thaliana MHK, and similar proteins. These proteins play important roles during meiosis. MAK is highly expressed in testicular cells specifically in the meiotic phase, but is not essential for spermatogenesis and fertility. It functions as a coactivator of the androgen receptor in prostate cells. MRK, also called Intestinal Cell Kinase (ICK), is expressed ubiquitously, with highest expression in the ovary and uterus. A missense mutation in MRK causes endocrine-cerebro-osteodysplasia, suggesting that this protein plays an important role in the development of many organs. MAK and MRK may be involved in regulating cell cycle and cell fate. Ime2p is a meiosis-specific kinase that is important during meiotic initiation and during the later stages of meiosis. Mde3 functions downstream of the transcription factor Mei-4 which is essential for meiotic prophase I. The MAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270824 [Multi-domain]  Cd Length: 283  Bit Score: 88.74  E-value: 5.69e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMnKQQCIERDEVRNVfRELEILQEI-EHVFLVNLWYSFQDEEDMFMVVDLLlGGDLrYHL---QQNVQFSEDTVRL 78
Cdd:cd07830   28 AIKKM-KKKFYSWEECMNL-REVKSLRKLnEHPNIVKLKEVFRENDELYFVFEYM-EGNL-YQLmkdRKGKPFSESVIRS 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIF-HSfvnggTGYSF 157
Cdd:cd07830  104 IIYQILQGLAHIHKHGFFHRDLKPENLLVSGPEVVKIADFGLAREIRSRPPYTDYVSTRWYRAPEILlRS-----TSYSS 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 158 EVDWWSVGVMAYELLRGwRPYdIHSSNAVEslvQLFSTVSV--------------------------------QYVPTWS 205
Cdd:cd07830  179 PVDIWALGCIMAELYTL-RPL-FPGSSEID---QLYKICSVlgtptkqdwpegyklasklgfrfpqfaptslhQLIPNAS 253
                        250       260
                 ....*....|....*....|....*.
gi 247269852 206 KEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd07830  254 PEAIDLIKDMLRWDPKKRPTASQALQ 279
PKc_MEK1 cd06650
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
18-177 5.70e-20

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 1; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK1 is a dual-specificity PK and a MAPK kinase (MAPKK or MKK) that phosphorylates and activates the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK1, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK1, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. MEK1 also plays a role in cell cycle control. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270816 [Multi-domain]  Cd Length: 319  Bit Score: 89.34  E-value: 5.70e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  18 VRN-VFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQH-I 95
Cdd:cd06650   46 IRNqIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHkI 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  96 IHRDVKPDNILLDEQGHAHLTDFNIATIIKDgERATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLRGW 175
Cdd:cd06650  126 MHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQ-----GTHYSVQSDIWSMGLSLVEMAVGR 199

                 ..
gi 247269852 176 RP 177
Cdd:cd06650  200 YP 201
STKc_CDKL cd07833
Catalytic domain of Cyclin-Dependent protein Kinase Like Serine/Threonine Kinases; STKs ...
14-177 5.74e-20

Catalytic domain of Cyclin-Dependent protein Kinase Like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDKL1-5 and similar proteins. Some CDKLs, like CDKL1 and CDKL3, may be implicated in transformation and others, like CDKL3 and CDKL5, are associated with mental retardation when impaired. CDKL2 plays a role in learning and memory. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270827 [Multi-domain]  Cd Length: 288  Bit Score: 88.91  E-value: 5.74e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  14 ERDEVRNV-FRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRS 92
Cdd:cd07833   39 DDEDVKKTaLREVKVLRQLRHENIVNLKEAFRRKGRLYLVFEYVERTLLELLEASPGGLPPDAVRSYIWQLLQAIAYCHS 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERA--TALAGTKPYMAPEIFHSFVNggtgYSFEVDWWSVGVMAYE 170
Cdd:cd07833  119 HNIIHRDIKPENILVSESGVLKLCDFGFARALTARPASplTDYVATRWYRAPELLVGDTN----YGKPVDVWAIGCIMAE 194

                 ....*..
gi 247269852 171 LLRGwRP 177
Cdd:cd07833  195 LLDG-EP 200
STKc_PAK5 cd06658
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5; STKs catalyze the ...
5-178 5.85e-20

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK5 is mainly expressed in the brain. It is not required for viability, but together with PAK6, it is required for normal levels of locomotion and activity, and for learning and memory. PAK5 cooperates with Inca (induced in neural crest by AP2) in the regulation of cell adhesion and cytoskeletal organization in the embryo and in neural crest cells during craniofacial development. PAK5 may also play a role in controlling the signaling of Raf-1, an effector of Ras, at the mitochondria. PAK5 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132989 [Multi-domain]  Cd Length: 292  Bit Score: 88.94  E-value: 5.85e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   5 KYMNKQQCIERDEVRN------VFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRyHLQQNVQFSEDTVRL 78
Cdd:cd06658   44 KHTGKQVAVKKMDLRKqqrrelLFNEVVIMRDYHHENVVDMYNSYLVGDELWVVMEFLEGGALT-DIVTHTRMNEEQIAT 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNI-ATIIKDGERATALAGTKPYMAPEIFHSFvnggtGYSF 157
Cdd:cd06658  123 VCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFcAQVSKEVPKRKSLVGTPYWMAPEVISRL-----PYGT 197
                        170       180
                 ....*....|....*....|.
gi 247269852 158 EVDWWSVGVMAYELLRGWRPY 178
Cdd:cd06658  198 EVDIWSLGIMVIEMIDGEPPY 218
STKc_CCRK cd07832
Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; STKs catalyze the ...
20-225 5.89e-20

Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CCRK was previously called p42. It is a Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) which is essential for the activation of CDK2. It is indispensable for cell growth and has been implicated in the progression of glioblastoma multiforme. In the heart, a splice variant of CCRK with a different C-terminal half is expressed; this variant promotes cardiac cell growth and survival and is significantly down-regulated during the development of heart failure. The CCRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270826 [Multi-domain]  Cd Length: 287  Bit Score: 88.54  E-value: 5.89e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  20 NVFRELEILQEIE-HVFLVNLWYSFQDEEDMFMVVDLLLGgDLrYHLQQNVQ--FSEDTVRLYICEMALALDYLRSQHII 96
Cdd:cd07832   45 QALREIKALQACQgHPYVVKLRDVFPHGTGFVLVFEYMLS-SL-SEVLRDEErpLTEAQVKRYMRMLLKGVAYMHANRIM 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  97 HRDVKPDNILLDEQGHAHLTDFNIATIIK-DGERA-TALAGTKPYMAPEIFHsfvnGGTGYSFEVDWWSVG-VMAyELLR 173
Cdd:cd07832  123 HRDLKPANLLISSTGVLKIADFGLARLFSeEDPRLySHQVATRWYRAPELLY----GSRKYDEGVDLWAVGcIFA-ELLN 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 174 GWRPYDihSSNAVESLVQLFSTVSVQYVPTW-----------------------------SKEMVALLRKLLTVNPEHRF 224
Cdd:cd07832  198 GSPLFP--GENDIEQLAIVLRTLGTPNEKTWpeltslpdynkitfpeskgirleeifpdcSPEAIDLLKGLLVYNPKKRL 275

                 .
gi 247269852 225 S 225
Cdd:cd07832  276 S 276
STKc_TSSK1_2-like cd14165
Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins; ...
3-223 8.35e-20

Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK1 and TSSK2 are expressed specifically in meiotic and postmeiotic spermatogenic cells, respectively. TSSK2 is localized in the sperm neck, equatorial segment, and mid-piece of the sperm tail. Both TSSK1 and TSSK2 phosphorylate their common substrate TSKS (testis-specific-kinase-substrate). TSSK1/TSSK2 double knock-out mice are sterile without manifesting other defects, making these kinases viable targets for male contraception. The TSSK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271067 [Multi-domain]  Cd Length: 263  Bit Score: 87.91  E-value: 8.35e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQcIERDEVRNVF-RELEILQEIEHVFLVNLWYSFQDEED-MFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14165   30 AIKIIDKKK-APDDFVEKFLpRELEILARLNHKSIIKTYEIFETSDGkVYIVMELGVQGDLLEFIKLRGALPEDVARKMF 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAT-IIKDGERATALA----GTKPYMAPEIFHsfvngGTGY 155
Cdd:cd14165  109 HQLSSAIKYCHELDIVHRDLKCENLLLDKDFNIKLTDFGFSKrCLRDENGRIVLSktfcGSAAYAAPEVLQ-----GIPY 183
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 156 SFEV-DWWSVGVMAYELLRGWRPYDihSSNAVESL-VQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHR 223
Cdd:cd14165  184 DPRIyDIWSLGVILYIMVCGSMPYD--DSNVKKMLkIQKEHRVRFPRSKNLTSECKDLIYRLLQPDVSQR 251
STKc_TSSK6-like cd14164
Catalytic domain of testis-specific serine/threonine kinase 6 and similar proteins; STKs ...
23-228 1.07e-19

Catalytic domain of testis-specific serine/threonine kinase 6 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK6, also called SSTK, is expressed at the head of elongated sperm. It can phosphorylate histones and associate with heat shock protens HSP90 and HSC70. Male mice deficient in TSSK6 are infertile, showing spermatogenic impairment including reduced sperm counts, impaired DNA condensation, abnormal morphology and decreased motility rates. The TSSK6-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271066 [Multi-domain]  Cd Length: 256  Bit Score: 87.22  E-value: 1.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKP 102
Cdd:cd14164   49 RELSILRRVNHPNIVQMFECIEVANGRLYIVMEAAATDLLQKIQEVHHIPKDLARDMFAQMVGAVNYLHDMNIVHRDLKC 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 103 DNILLDEQG-HAHLTDFNIATIIKD-GERATALAGTKPYMAPEIFhsfvnggTGYSFE---VDWWSVGVMAYELLRGWRP 177
Cdd:cd14164  129 ENILLSADDrKIKIADFGFARFVEDyPELSTTFCGSRAYTPPEVI-------LGTPYDpkkYDVWSLGVVLYVMVTGTMP 201
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 247269852 178 YDIHSSNAV---ESLVQLFSTVSVqyvptwSKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd14164  202 FDETNVRRLrlqQRGVLYPSGVAL------EEPCRALIRTLLQFNPSTRPSIQQ 249
STKc_PLK2 cd14188
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2; STKs catalyze the ...
1-223 1.63e-19

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK2, also called Snk (serum-inducible kinase), functions in G1 progression, S-phase arrest, and centriole duplication. Its gene is responsive to both growth factors and cellular stress, is a transcriptional target of p53, and activates a G2-M checkpoint. The PLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271090 [Multi-domain]  Cd Length: 255  Bit Score: 86.99  E-value: 1.63e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14188   28 VYAAKIIPHSRVSKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYL 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKD-GERATALAGTKPYMAPEIFHSfvnggTGYSFEV 159
Cdd:cd14188  108 RQIVSGLKYLHEQEILHRDLKLGNFFINENMELKVGDFGLAARLEPlEHRRRTICGTPNYLSPEVLNK-----QGHGCES 182
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 247269852 160 DWWSVGVMAYELLRGWRPYDIHSSNAV-----ESLVQLFSTVSVQyvptwSKEMVAllrKLLTVNPEHR 223
Cdd:cd14188  183 DIWALGCVMYTMLLGRPPFETTNLKETyrcirEARYSLPSSLLAP-----AKHLIA---SMLSKNPEDR 243
STKc_IKK_alpha cd14039
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
23-178 1.64e-19

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IKKalpha is involved in the non-canonical or alternative pathway of regulating Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. The non-canonical pathway functions in cells lacking NEMO (NF-kB Essential MOdulator) and IKKbeta. It is induced by a subset of TNFR family members including CD40, RANK, and B cell-activating factor receptor. IKKalpha processes the Inhibitor of NF-kB (IkB)-like C-terminus of NF-kB2/p100 to produce p52, allowing the p52/RelB dimer to migrate to the nucleus. This pathway is dependent on NIK (NF-kB Inducing Kinase) which phosphorylates and activates IKKalpha. The IKKalpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270941 [Multi-domain]  Cd Length: 289  Bit Score: 87.67  E-value: 1.64e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLwySFQDEEDMFMVVDLLL-------GGDLRYHLQQNVQ---FSEDTVRLYICEMALALDYLRS 92
Cdd:cd14039   40 HEIQIMKKLNHPNVVKA--CDVPEEMNFLVNDVPLlameycsGGDLRKLLNKPENccgLKESQVLSLLSDIGSGIQYLHE 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILLDEQGHA---HLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAY 169
Cdd:cd14039  118 NKIIHRDLKPENIVLQEINGKivhKIIDLGYAKDLDQGSLCTSFVGTLQYLAPELFE-----NKSYTVTVDYWSFGTMVF 192

                 ....*....
gi 247269852 170 ELLRGWRPY 178
Cdd:cd14039  193 ECIAGFRPF 201
STKc_Nek6 cd08228
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
4-223 1.67e-19

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek6 is required for the transition from metaphase to anaphase. It also plays important roles in mitotic spindle formation and cytokinesis. Activated by Nek9 during mitosis, Nek6 phosphorylates Eg5, a kinesin that is important for spindle bipolarity. Nek6 localizes to spindle microtubules during metaphase and anaphase, and to the midbody during cytokinesis. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270865 [Multi-domain]  Cd Length: 268  Bit Score: 87.01  E-value: 1.67e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   4 MKYMNKQQCIerdevrnvfRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDL----RYHLQQNVQFSEDTVRLY 79
Cdd:cd08228   41 MDAKARQDCV---------KEIDLLKQLNHPNVIKYLDSFIEDNELNIVLELADAGDLsqmiKYFKKQKRLIPERTVWKY 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERAT-ALAGTKPYMAPEIFHSfvnggTGYSFE 158
Cdd:cd08228  112 FVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAhSLVGTPYYMSPERIHE-----NGYNFK 186
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDIHSSNAVeSLVQLFSTVSVQYVPT--WSKEMVALLRKLLTVNPEHR 223
Cdd:cd08228  187 SDIWSLGCLLYEMAALQSPFYGDKMNLF-SLCQKIEQCDYPPLPTehYSEKLRELVSMCIYPDPDQR 252
STKc_Kin1_2 cd14077
Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases; STKs catalyze the ...
14-223 1.87e-19

Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of yeast Kin1, Kin2, and similar proteins. Fission yeast Kin1 is a membrane-associated kinase that is involved in regulating cell surface cohesiveness during interphase. It also plays a role during mitosis, linking actomyosin ring assembly with septum synthesis and membrane closure to ensure separation of daughter cells. Budding yeast Kin1 and Kin2 act downstream of the Rab-GTPase Sec4 and are associated with the exocytic apparatus; they play roles in the secretory pathway. The Kin1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270979 [Multi-domain]  Cd Length: 267  Bit Score: 86.73  E-value: 1.87e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  14 ERDEVRnVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQ 93
Cdd:cd14077   54 ISRDIR-TIREAALSSLLNHPHICRLRDFLRTPNHYYMLFEYVDGGQLLDYIISHGKLKEKQARKFARQIASALDYLHRN 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  94 HIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSfvNGGTGYsfEVDWWSVGVMAYELLR 173
Cdd:cd14077  133 SIVHRDLKIENILISKSGNIKIIDFGLSNLYDPRRLLRTFCGSLYFAAPELLQA--QPYTGP--EVDVWSFGVVLYVLVC 208
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 247269852 174 GWRPYDIHSSNAVESLVQlfsTVSVQYVPTWSKEMVALLRKLLTVNPEHR 223
Cdd:cd14077  209 GKVPFDDENMPALHAKIK---KGKVEYPSYLSSECKSLISRMLVVDPKKR 255
PTZ00036 PTZ00036
glycogen synthase kinase; Provisional
23-276 2.08e-19

glycogen synthase kinase; Provisional


Pssm-ID: 173333 [Multi-domain]  Cd Length: 440  Bit Score: 88.94  E-value: 2.08e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHV---FLVNLWYS---FQDEEDMFMVVDL-----LLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLR 91
Cdd:PTZ00036 108 RELLIMKNLNHIniiFLKDYYYTecfKKNEKNIFLNVVMefipqTVHKYMKHYARNNHALPLFLVKLYSYQLCRALAYIH 187
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  92 SQHIIHRDVKPDNILLDEQGHA-HLTDFNIATIIKDGERATALAGTKPYMAPEIfhsfVNGGTGYSFEVDWWSVGVMAYE 170
Cdd:PTZ00036 188 SKFICHRDLKPQNLLIDPNTHTlKLCDFGSAKNLLAGQRSVSYICSRFYRAPEL----MLGATNYTTHIDLWSLGCIIAE 263
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 171 LLRGWRPYDIHSSnaVESLVQLFSTV----------------SVQYVPTWSKEM------------VALLRKLLTVNPEH 222
Cdd:PTZ00036 264 MILGYPIFSGQSS--VDQLVRIIQVLgtptedqlkemnpnyaDIKFPDVKPKDLkkvfpkgtpddaINFISQFLKYEPLK 341
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 247269852 223 RFSSLQdmqtapSLAHVLWDDLSEKKVE-PGFVPNKGRLHCDPTFELEEMILESR 276
Cdd:PTZ00036 342 RLNPIE------ALADPFFDDLRDPCIKlPKYIDKLPDLFNFCDAEIKEMSDACR 390
STKc_MAPK15-like cd07852
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and ...
22-228 2.70e-19

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Human MAPK15 is also called Extracellular signal Regulated Kinase 8 (ERK8) while the rat protein is called ERK7. ERK7 and ERK8 display both similar and different biochemical properties. They autophosphorylate and activate themselves and do not require upstream activating kinases. ERK7 is constitutively active and is not affected by extracellular stimuli whereas ERK8 shows low basal activity and is activated by DNA-damaging agents. ERK7 and ERK8 also have different substrate profiles. Genome analysis shows that they are orthologs with similar gene structures. ERK7 and ERK 8 may be involved in the signaling of some nuclear receptor transcription factors. ERK7 regulates hormone-dependent degradation of estrogen receptor alpha while ERK8 down-regulates the transcriptional co-activation androgen and glucocorticoid receptors. MAPKs are important mediators of cellular responses to extracellular signals. The MAPK15 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270841 [Multi-domain]  Cd Length: 337  Bit Score: 87.61  E-value: 2.70e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  22 FRELEILQEI-EHVFLVNLW--YSFQDEEDMFMVVDLL---LGGDLRYHLQQNVQfsedtVRLYICEMALALDYLRSQHI 95
Cdd:cd07852   54 FREIMFLQELnDHPNIIKLLnvIRAENDKDIYLVFEYMetdLHAVIRANILEDIH-----KQYIMYQLLKALKYLHSGGV 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  96 IHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALA------GTKPYMAPEIfhsfVNGGTGYSFEVDWWSVGVMAY 169
Cdd:cd07852  129 IHRDLKPSNILLNSDCRVKLADFGLARSLSQLEEDDENPvltdyvATRWYRAPEI----LLGSTRYTKGVDMWSVGCILG 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 170 ELLRG--------------------WRPY--DIHSSNAVESLVQLFSTVSVQYV------PTWSKEMVALLRKLLTVNPE 221
Cdd:cd07852  205 EMLLGkplfpgtstlnqlekiieviGRPSaeDIESIQSPFAATMLESLPPSRPKsldelfPKASPDALDLLKKLLVFNPN 284

                 ....*..
gi 247269852 222 HRFSSLQ 228
Cdd:cd07852  285 KRLTAEE 291
PTKc cd00192
Catalytic domain of Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
3-178 3.12e-19

Catalytic domain of Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. They can be classified into receptor and non-receptor tyr kinases. PTKs play important roles in many cellular processes including, lymphocyte activation, epithelium growth and maintenance, metabolism control, organogenesis regulation, survival, proliferation, differentiation, migration, adhesion, motility, and morphogenesis. Receptor tyr kinases (RTKs) are integral membrane proteins which contain an extracellular ligand-binding region, a transmembrane segment, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain, leading to intracellular signaling. Some RTKs are orphan receptors with no known ligands. Non-receptor (or cytoplasmic) tyr kinases are distributed in different intracellular compartments and are usually multi-domain proteins containing a catalytic tyr kinase domain as well as various regulatory domains such as SH3 and SH2. PTKs are usually autoinhibited and require a mechanism for activation. In many PTKs, the phosphorylation of tyr residues in the activation loop is essential for optimal activity. Aberrant expression of PTKs is associated with many development abnormalities and cancers.The PTK family is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270623 [Multi-domain]  Cd Length: 262  Bit Score: 86.05  E-value: 3.12e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKqqCIERDEVRNVFRELEILQEIEHVFLVNL--WYSfqDEEDMFMVVDLLLGGDLRYHLQQN----VQFSEDTV 76
Cdd:cd00192   27 AVKTLKE--DASESERKDFLKEARVMKKLGHPNVVRLlgVCT--EEEPLYLVMEYMEGGDLLDFLRKSrpvfPSPEPSTL 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  77 RL-----YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTK-P--YMAPEIFHSF 148
Cdd:cd00192  103 SLkdllsFAIQIAKGMEYLASKKFVHRDLAARNCLVGEDLVVKISDFGLSRDIYDDDYYRKKTGGKlPirWMAPESLKDG 182
                        170       180       190
                 ....*....|....*....|....*....|.
gi 247269852 149 VnggtgYSFEVDWWSVGVMAYELL-RGWRPY 178
Cdd:cd00192  183 I-----FTSKSDVWSFGVLLWEIFtLGATPY 208
STKc_Kin4 cd14076
Catalytic domain of the yeast Serine/Threonine Kinase, Kin4; STKs catalyze the transfer of the ...
3-223 3.55e-19

Catalytic domain of the yeast Serine/Threonine Kinase, Kin4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Kin4 is a central component of the spindle position checkpoint (SPOC), which monitors spindle position and regulates the mitotic exit network (MEN). Kin4 associates with spindle pole bodies in mother cells to inhibit MEN signaling and delay mitosis until the anaphase nucleus is properly positioned along the mother-bud axis. Kin4 activity is regulated by both the bud neck-associated kinase Elm1 and protein phosphatase 2A. The Kin4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270978 [Multi-domain]  Cd Length: 270  Bit Score: 86.38  E-value: 3.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICE 82
Cdd:cd14076   35 AIKLIRRDTQQENCQTSKIMREINILKGLTHPNIVRLLDVLKTKKYIGIVLEFVSGGELFDYILARRRLKDSVACRLFAQ 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATII--KDGERATALAGTKPYMAPEIfhsfVNGGTGYS-FEV 159
Cdd:cd14076  115 LISGVAYLHKKGVVHRDLKLENLLLDKNRNLVITDFGFANTFdhFNGDLMSTSCGSPCYAAPEL----VVSDSMYAgRKA 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 247269852 160 DWWSVGVMAYELLRGWRPYDIHSSNAV-ESLVQLFSTVS------VQYVPTWSKEmvaLLRKLLTVNPEHR 223
Cdd:cd14076  191 DIWSCGVILYAMLAGYLPFDDDPHNPNgDNVPRLYRYICntplifPEYVTPKARD---LLRRILVPNPRKR 258
PKc_MEK2 cd06649
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
18-177 4.06e-19

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 2; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK2 is a dual-specificity PK and a MAPK kinase (MAPKK or MKK) that phosphorylates and activates the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK2, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK2, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132980 [Multi-domain]  Cd Length: 331  Bit Score: 87.03  E-value: 4.06e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  18 VRN-VFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQH-I 95
Cdd:cd06649   46 IRNqIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHqI 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  96 IHRDVKPDNILLDEQGHAHLTDFNIATIIKDgERATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLRGW 175
Cdd:cd06649  126 MHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQ-----GTHYSVQSDIWSMGLSLVELAIGR 199

                 ..
gi 247269852 176 RP 177
Cdd:cd06649  200 YP 201
STKc_Cdc7 cd14019
Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase; STKs catalyze ...
21-226 4.11e-19

Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Cdc7 kinase (or Hsk1 in fission yeast) is a critical regulator in the initiation of DNA replication. It forms a complex with a Dbf4-related regulatory subunit, a cyclin-like molecule that activates the kinase in late G1 phase, and is also referred to as Dbf4-dependent kinase (DDK). Its main targets are mini-chromosome maintenance (MCM) proteins. Cdc7 kinase may also have additional roles in meiosis, checkpoint responses, the maintenance and repair of chromosome structures, and cancer progression. The Cdc7 kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270921 [Multi-domain]  Cd Length: 252  Bit Score: 85.74  E-value: 4.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  21 VFRELEILQEIE-HVFLVNLWYSFQDEEDMFMVVDLLLGGDLR--YHlqqnvQFSEDTVRLYICEMALALDYLRSQHIIH 97
Cdd:cd14019   50 ILNELECLERLGgSNNVSGLITAFRNEDQVVAVLPYIEHDDFRdfYR-----KMSLTDIRIYLRNLFKALKHVHSFGIIH 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  98 RDVKPDNILLD-EQGHAHLTDFNIATIIKDGERATA-LAGTKPYMAPEIFHSFVNGGTgysfEVDWWSVGVMAYELLRGW 175
Cdd:cd14019  125 RDVKPGNFLYNrETGKGVLVDFGLAQREEDRPEQRApRAGTRGFRAPEVLFKCPHQTT----AIDIWSAGVILLSILSGR 200
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 247269852 176 RPYdIHSSNAVESLVQLFSTvsvqyvpTWSKEMVALLRKLLTVNPEHRFSS 226
Cdd:cd14019  201 FPF-FFSSDDIDALAEIATI-------FGSDEAYDLLDKLLELDPSKRITA 243
STKc_p38alpha cd07877
Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase ...
19-274 6.35e-19

Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38alpha/MAPK14 is expressed in most tissues and is the major isoform involved in the immune and inflammatory response. It is the central p38 MAPK involved in myogenesis. It plays a role in regulating cell cycle check-point transition and promoting cell differentiation. p38alpha also regulates cell proliferation and death through crosstalk with the JNK pathway. Its substrates include MAPK activated protein kinase 2 (MK2), MK5, and the transcription factors ATF2 and Mitf. p38 kinases MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143382 [Multi-domain]  Cd Length: 345  Bit Score: 86.63  E-value: 6.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  19 RNVFRELEILQEIEHVFLVNLW------YSFQDEEDMFMVVDLLlGGDLRyHLQQNVQFSEDTVRLYICEMALALDYLRS 92
Cdd:cd07877   61 KRTYRELRLLKHMKHENVIGLLdvftpaRSLEEFNDVYLVTHLM-GADLN-NIVKCQKLTDDHVQFLIYQILRGLKYIHS 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILLDEQGHAHLTDFNIATiiKDGERATALAGTKPYMAPEIFHSFVNggtgYSFEVDWWSVGVMAYELL 172
Cdd:cd07877  139 ADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVATRWYRAPEIMLNWMH----YNQTVDIWSVGCIMAELL 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 173 RGWR--PYDIH--------------------------SSNAVESLVQL----FSTVSVQYVPtwskEMVALLRKLLTVNP 220
Cdd:cd07877  213 TGRTlfPGTDHidqlklilrlvgtpgaellkkissesARNYIQSLTQMpkmnFANVFIGANP----LAVDLLEKMLVLDS 288
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 247269852 221 EHRFSSlqdmqtAPSLAHVLWDDLSEKKVEPGFVPNkgrlhcDPTFELEEMILE 274
Cdd:cd07877  289 DKRITA------AQALAHAYFAQYHDPDDEPVADPY------DQSFESRDLLID 330
STKc_RSK4_C cd14177
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called ...
2-228 7.86e-19

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK4 is also called S6K-alpha-6, RPS6KA6, p90RSK6 or pp90RSK4. RSK4 is a substrate of ERK and is a modulator of p53-dependent proliferation arrest in human cells. Deletion of the RSK4 gene, RPS6KA6, frequently occurs in patients of X-linked deafness type 3, mental retardation and choroideremia. Studies of RSK4 in cancer cells and tissues suggest that it may be oncogenic or tumor suppressive depending on many factors. RSK4 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271079 [Multi-domain]  Cd Length: 295  Bit Score: 85.84  E-value: 7.86e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQcierdevRNVFRELEILQEI-EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14177   32 FAVKIIDKSK-------RDPSEEIEILMRYgQHPNIITLKDVYDDGRYVYLVTELMKGGELLDRILRQKFFSEREASAVL 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNIL-LDEQGHA---HLTDFNIATIIKdGERATALAG--TKPYMAPEIFHSfvnggTG 154
Cdd:cd14177  105 YTITKTVDYLHCQGVVHRDLKPSNILyMDDSANAdsiRICDFGFAKQLR-GENGLLLTPcyTANFVAPEVLMR-----QG 178
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 155 YSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVES-LVQLFS---TVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd14177  179 YDAACDIWSLGVLLYTMLAGYTPFANGPNDTPEEiLLRIGSgkfSLSGGNWDTVSDAAKDLLSHMLHVDPHQRYTAEQ 256
STKc_RSK1_C cd14175
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called ...
2-231 8.05e-19

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK1 is also called S6K-alpha-1, RPS6KA1, p90RSK1 or MAPK-activated protein kinase 1a (MAPKAPK-1a). It is a component of the insulin transduction pathway, regulating the function of IRS1. It also interacts with PKA and promotes its inactivation. RSK1 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271077 [Multi-domain]  Cd Length: 291  Bit Score: 85.46  E-value: 8.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQcierdevRNVFRELEILQEI-EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14175   29 YAVKVIDKSK-------RDPSEEIEILLRYgQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASSVL 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNIL-LDEQGHAH---LTDFNIATIIK-DGERATALAGTKPYMAPEIFHSfvnggTGY 155
Cdd:cd14175  102 HTICKTVEYLHSQGVVHRDLKPSNILyVDESGNPEslrICDFGFAKQLRaENGLLMTPCYTANFVAPEVLKR-----QGY 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 156 SFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFS----TVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd14175  177 DEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGsgkfTLSGGNWNTVSDAAKDLVSKMLHVDPHQRLTAKQVLQ 256
STKc_PFTAIRE2 cd07870
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase; STKs catalyze the transfer ...
23-246 8.39e-19

Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PFTAIRE-2 is also referred to as ALS2CR7 (amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 7). It may be associated with amyotrophic lateral sclerosis 2 (ALS2), an autosomal recessive form of juvenile ALS. The function of PFTAIRE-2 is not yet known. It shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PFTAIRE-2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270852 [Multi-domain]  Cd Length: 286  Bit Score: 85.40  E-value: 8.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKP 102
Cdd:cd07870   47 REASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMIQHPGGLHPYNVRLFMFQLLRGLAYIHGQHILHRDLKP 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 103 DNILLDEQGHAHLTDFNIAtiikdgeRATALAG--------TKPYMAPEIFHsfvnGGTGYSFEVDWWSVGVMAYELLRG 174
Cdd:cd07870  127 QNLLISYLGELKLADFGLA-------RAKSIPSqtyssevvTLWYRPPDVLL----GATDYSSALDIWGAGCIFIEMLQG 195
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 247269852 175 wRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKemvalLRKLLTVNPEhrfssLQDMQTAPSLaHVLWDDLSE 246
Cdd:cd07870  196 -QPAFPGVSDVFEQLEKIWTVLGVPTEDTWPG-----VSKLPNYKPE-----WFLPCKPQQL-RVVWKRLSR 255
PKc_MKK7 cd06618
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
86-179 9.17e-19

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK7 is a dual-specificity PK that phosphorylates and activates its downstream target, c-Jun N-terminal kinase (JNK), on specific threonine and tyrosine residues. Although MKK7 is capable of dual phosphorylation, it prefers to phosphorylate the threonine residue of JNK. Thus, optimal activation of JNK requires both MKK4 and MKK7. MKK7 is primarily activated by cytokines. MKK7 is essential for liver formation during embryogenesis. It plays roles in G2/M cell cycle arrest and cell growth. In addition, it is involved in the control of programmed cell death, which is crucial in oncogenesis, cancer chemoresistance, and antagonism to TNFalpha-induced killing, through its inhibition by Gadd45beta and the subsequent suppression of the JNK cascade. The MKK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270791 [Multi-domain]  Cd Length: 295  Bit Score: 85.50  E-value: 9.17e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  86 ALDYLRSQH-IIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSFVNGgtGYSFEVDWWSV 164
Cdd:cd06618  126 ALHYLKEKHgVIHRDVKPSNILLDESGNVKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDNP--KYDIRADVWSL 203
                         90
                 ....*....|....*
gi 247269852 165 GVMAYELLRGWRPYD 179
Cdd:cd06618  204 GISLVELATGQFPYR 218
STKc_Nek7 cd08229
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
20-223 9.32e-19

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek7 is required for mitotic spindle formation and cytokinesis. It is enriched in the centrosome and is critical for microtubule nucleation. Nek7 is activated by Nek9 during mitosis, and may regulate the p70 ribosomal S6 kinase. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270866 [Multi-domain]  Cd Length: 292  Bit Score: 85.47  E-value: 9.32e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  20 NVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDL----RYHLQQNVQFSEDTVRLYICEMALALDYLRSQHI 95
Cdd:cd08229   70 DCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLsrmiKHFKKQKRLIPEKTVWKYFVQLCSALEHMHSRRV 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  96 IHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERAT-ALAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELLRG 174
Cdd:cd08229  150 MHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAhSLVGTPYYMSPERIHE-----NGYNFKSDIWSLGCLLYEMAAL 224
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 247269852 175 WRPYDIHSSNaVESLVQLFSTVSVQYVPT--WSKEMVALLRKLLTVNPEHR 223
Cdd:cd08229  225 QSPFYGDKMN-LYSLCKKIEQCDYPPLPSdhYSEELRQLVNMCINPDPEKR 274
STKc_RSK2_C cd14176
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called ...
2-228 9.85e-19

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK2 is also called p90RSK3, RPS6KA3, S6K-alpha-3, or MAPK-activated protein kinase 1b (MAPKAPK-1b). RSK2 is expressed highly in the regions of the brain with high synaptic activity. It plays a role in the maintenance and consolidation of excitatory synapses. It is a specific modulator of phospholipase D in calcium-regulated exocytosis. Mutations in the RSK2 gene, RPS6KA3, cause Coffin-Lowry syndrome (CLS), a rare syndromic form of X-linked mental retardation characterized by growth and psychomotor retardation and skeletal abnormalities. RSK2 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271078 [Multi-domain]  Cd Length: 339  Bit Score: 86.23  E-value: 9.85e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQcierdevRNVFRELEILQEI-EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14176   47 FAVKIIDKSK-------RDPTEEIEILLRYgQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVL 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNIL-LDEQGHAH---LTDFNIATIIKdGERATALAG--TKPYMAPEIFHSfvnggTG 154
Cdd:cd14176  120 FTITKTVEYLHAQGVVHRDLKPSNILyVDESGNPEsirICDFGFAKQLR-AENGLLMTPcyTANFVAPEVLER-----QG 193
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 155 YSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFS----TVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd14176  194 YDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGsgkfSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAAL 271
STKc_MLCK1 cd14191
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1; STKs catalyze ...
1-178 1.44e-18

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK1 (or MYLK1) phosphorylates myosin regulatory light chain and controls the contraction of smooth muscles. The MLCK1 gene expresses three transcripts in a cell-specific manner: a short MLCK1 which contains three immunoglobulin (Ig)-like and one fibronectin type III (FN3) domains, PEVK and actin-binding regions, and a kinase domain near the C-terminus followed by a regulatory segment containing an autoinhibitory Ca2+/calmodulin binding site; a long MLCK1 containing six additional Ig-like domains at the N-terminus compared to the short MLCK1; and the C-terminal Ig module which results in the expression of telokin in phasic smooth muscles, leading to Ca2+ desensitization by cyclic nucleotides of smooth muscle force. MLCK1 is also responsible for myosin regulatory light chain phosphorylation in nonmuscle cells and may play a role in regulating myosin II ATPase activity. The MLCK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271093 [Multi-domain]  Cd Length: 259  Bit Score: 84.29  E-value: 1.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNvfrELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL-QQNVQFSEDTVRLY 79
Cdd:cd14191   29 VWAGKFFKAYSAKEKENIRQ---EISIMNCLHHPKLVQCVDAFEEKANIVMVLEMVSGGELFERIiDEDFELTERECIKY 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNIL-LDEQGHA-HLTDFNIATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSF 157
Cdd:cd14191  106 MRQISEGVEYIHKQGIVHLDLKPENIMcVNKTGTKiKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINY-----EPIGY 180
                        170       180
                 ....*....|....*....|.
gi 247269852 158 EVDWWSVGVMAYELLRGWRPY 178
Cdd:cd14191  181 ATDMWSIGVICYILVSGLSPF 201
STKc_MST4 cd06640
Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4; STKs ...
16-181 1.56e-18

Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MST4 is sometimes referred to as MASK (MST3 and SOK1-related kinase). It plays a role in mitogen-activated protein kinase (MAPK) signaling during cytoskeletal rearrangement, morphogenesis, and apoptosis. It influences cell growth and transformation by modulating the extracellular signal-regulated kinase (ERK) pathway. MST4 may also play a role in tumor formation and progression. It localizes in the Golgi apparatus by interacting with the Golgi matrix protein GM130 and may play a role in cell migration. The MST4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132971 [Multi-domain]  Cd Length: 277  Bit Score: 84.72  E-value: 1.56e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  16 DEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHI 95
Cdd:cd06640   44 DEIEDIQQEITVLSQCDSPYVTKYYGSYLKGTKLWIIMEYL-GGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKK 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  96 IHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE-RATALAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELLRG 174
Cdd:cd06640  123 IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQiKRNTFVGTPFWMAPEVIQQ-----SAYDSKADIWSLGITAIELAKG 197

                 ....*...
gi 247269852 175 WRP-YDIH 181
Cdd:cd06640  198 EPPnSDMH 205
STKc_PAK4 cd06657
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4; STKs catalyze the ...
1-178 1.70e-18

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK4 regulates cell morphology and cytoskeletal organization. It is essential for embryonic viability and proper neural development. Mice lacking PAK4 die due to defects in the fetal heart. In addition, their spinal cord motor neurons showed failure to differentiate and migrate. PAK4 also plays a role in cell survival and tumorigenesis. It is overexpressed in many primary tumors including colon, esophageal, and mammary tumors. PAK4 has also been implicated in viral and bacterial infection pathways. PAK4 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132988 [Multi-domain]  Cd Length: 292  Bit Score: 84.69  E-value: 1.70e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMN--KQQcieRDEVrnVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRyHLQQNVQFSEDTVRL 78
Cdd:cd06657   47 LVAVKKMDlrKQQ---RREL--LFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALT-DIVTHTRMNEEQIAA 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNI-ATIIKDGERATALAGTKPYMAPEIFHSFvnggtGYSF 157
Cdd:cd06657  121 VCLAVLKALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFcAQVSKEVPRRKSLVGTPYWMAPELISRL-----PYGP 195
                        170       180
                 ....*....|....*....|.
gi 247269852 158 EVDWWSVGVMAYELLRGWRPY 178
Cdd:cd06657  196 EVDIWSLGIMVIEMVDGEPPY 216
STKc_PASK cd14004
Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase; STKs ...
24-236 1.91e-18

Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PASK (or PASKIN) is a nutrient and energy sensor and thus, plays an important role in maintaining cellular energy homeostasis. It coordinates the utilization of glucose in response to metabolic demand. It contains an N-terminal PAS domain which directly interacts and inhibits a C-terminal catalytic kinase domain. The PAS domain serves as a sensory module for different environmental signals such as light, redox state, and various metabolites. Binding of ligands to the PAS domain causes structural changes which leads to kinase activation and the phosphorylation of substrates to trigger the appropriate cellular response. The PASK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270906 [Multi-domain]  Cd Length: 256  Bit Score: 83.98  E-value: 1.91e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  24 ELEILQEIE---HVFLVNLWYSFQDEEDMFMVVDLL-LGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRD 99
Cdd:cd14004   55 EIHILDTLNkrsHPNIVKLLDFFEDDEFYYLVMEKHgSGMDLFDFIERKPNMDEKEAKYIFRQVADAVKHLHDQGIVHRD 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 100 VKPDNILLDEQGHAHLTDFNIATIIKDGERATaLAGTKPYMAPEIFhsfvnGGTGY-SFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd14004  135 IKDENVILDGNGTIKLIDFGSAAYIKSGPFDT-FVGTIDYAAPEVL-----RGNPYgGKEQDIWALGVLLYTLVFKENPF 208
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 179 ---------DIHSSNAVeslvqlfstvsvqyvptwSKEMVALLRKLLTVNPEHRfSSLQDMQTAPSL 236
Cdd:cd14004  209 ynieeileaDLRIPYAV------------------SEDLIDLISRMLNRDVGDR-PTIEELLTDPWL 256
STKc_RPK118_like cd05576
Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins; STKs catalyze ...
59-223 1.92e-18

Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RPK118 contains an N-terminal Phox homology (PX) domain, a Microtubule Interacting and Trafficking (MIT) domain, and a kinase domain containing a long uncharacterized insert. Also included in the family is human RPK60 (or ribosomal protein S6 kinase-like 1), which also contains MIT and kinase domains but lacks a PX domain. RPK118 binds sphingosine kinase, a key enzyme in the synthesis of sphingosine 1-phosphate (SPP), a lipid messenger involved in many cellular events. RPK118 may be involved in transmitting SPP-mediated signaling. RPK118 also binds the antioxidant peroxiredoxin-3. RPK118 may be involved in the transport of PRDX3 from the cytoplasm to its site of function in the mitochondria. The RPK118-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270728 [Multi-domain]  Cd Length: 265  Bit Score: 84.13  E-value: 1.92e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  59 GDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALagTKP 138
Cdd:cd05576   98 LDERLAAASRFYIPEECIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAI--ENM 175
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 139 YMAPEifhsfVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNaveslVQLFSTVSvqyVPTW-SKEMVALLRKLLT 217
Cdd:cd05576  176 YCAPE-----VGGISEETEACDWWSLGALLFELLTGKALVECHPAG-----INTHTTLN---IPEWvSEEARSLLQQLLQ 242

                 ....*.
gi 247269852 218 VNPEHR 223
Cdd:cd05576  243 FNPTER 248
STKc_MST3 cd06641
Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 3; STKs ...
16-178 2.35e-18

Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MST3 phosphorylates the STK NDR and may play a role in cell cycle progression and cell morphology. It may also regulate paxillin and consequently, cell migration. MST3 is present in human placenta, where it plays an essential role in the oxidative stress-induced apoptosis of trophoblasts in normal spontaneous delivery. Dysregulation of trophoblast apoptosis may result in pregnancy complications such as preeclampsia and intrauterine growth retardation. The MST3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270809 [Multi-domain]  Cd Length: 277  Bit Score: 83.97  E-value: 2.35e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  16 DEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHI 95
Cdd:cd06641   44 DEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYL-GGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKK 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  96 IHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE-RATALAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELLRG 174
Cdd:cd06641  123 IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQiKRN*FVGTPFWMAPEVIKQ-----SAYDSKADIWSLGITAIELARG 197

                 ....
gi 247269852 175 WRPY 178
Cdd:cd06641  198 EPPH 201
STKc_TLK1 cd14040
Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1; STKs catalyze the ...
15-228 2.90e-18

Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. A splice variant of TLK1, called TLK1B, is expressed in the presence of double strand breaks (DSBs). It lacks the N-terminal part of TLK1, but is expected to phosphorylate the same substrates. TLK1/1B interacts with Rad9, which is critical in DNA damage-activated checkpoint response, and plays a role in the repair of linearized DNA with incompatible ends. TLKs play important functions during the cell cycle and are implicated in chromatin remodeling, DNA replication and repair, and mitosis. The TLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270942 [Multi-domain]  Cd Length: 299  Bit Score: 84.34  E-value: 2.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  15 RDEVRNVF-----RELEILQEIEHVFLVNLWYSFQDEEDMF-MVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALD 88
Cdd:cd14040   46 RDEKKENYhkhacREYRIHKELDHPRIVKLYDYFSLDTDTFcTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALR 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  89 YLRS--QHIIHRDVKPDNILLDEQ---GHAHLTDFNIATIIKDG-------ERATALAGTKPYMAPEifhSFVNGGT--G 154
Cdd:cd14040  126 YLNEikPPIIHYDLKPGNILLVDGtacGEIKITDFGLSKIMDDDsygvdgmDLTSQGAGTYWYLPPE---CFVVGKEppK 202
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 247269852 155 YSFEVDWWSVGVMAYELLRGWRPYDIHSSNavESLVQ---LFSTVSVQY--VPTWSKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd14040  203 ISNKVDVWSVGVIFFQCLYGRKPFGHNQSQ--QDILQentILKATEVQFpvKPVVSNEAKAFIRRCLAYRKEDRFDVHQ 279
STKc_MSK2_C cd14180
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
2-225 3.15e-18

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK2 and MSK1 play nonredundant roles in activating histone H3 kinases, which play pivotal roles in compaction of the chromatin fiber. MSK2 is the required H3 kinase in response to stress stimuli and activation of the p38 MAPK pathway. MSK2 also plays a role in the pathogenesis of psoriasis. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family, similar to 90 kDa ribosomal protein S6 kinases (RSKs). MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271082 [Multi-domain]  Cd Length: 309  Bit Score: 84.15  E-value: 3.15e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKqqcieRDEVrNVFRELEILQEIE-HVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14180   34 YAVKIISR-----RMEA-NTQREVAALRLCQsHPNIVALHEVLHDQYHTYLVMELLRGGELLDRIKKKARFSESEASQLM 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHA---HLTDFNIATIIKDGERATALAG-TKPYMAPEIFHSfvnggTGYS 156
Cdd:cd14180  108 RSLVSAVSFMHEAGVVHRDLKPENILYADESDGavlKVIDFGFARLRPQGSRPLQTPCfTLQYAAPELFSN-----QGYD 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 157 FEVDWWSVGVMAYELLRGWRPYDIH-----SSNAVESLVQL----FSTVSvqyvPTW---SKEMVALLRKLLTVNPEHRF 224
Cdd:cd14180  183 ESCDLWSLGVILYTMLSGQVPFQSKrgkmfHNHAADIMHKIkegdFSLEG----EAWkgvSEEAKDLVRGLLTVDPAKRL 258

                 .
gi 247269852 225 S 225
Cdd:cd14180  259 K 259
PKc_MEK cd06615
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
15-177 3.47e-18

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK1 and MEK2 are MAPK kinases (MAPKKs or MKKs), and are dual-specificity PKs that phosphorylate and activate the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK1/2, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. This cascade has also been implicated in synaptic plasticity, migration, morphological determination, and stress response immunological reactions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK1/2, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132946 [Multi-domain]  Cd Length: 308  Bit Score: 84.02  E-value: 3.47e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  15 RDEVRN-VFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTV-RLYICeMALALDYLRS 92
Cdd:cd06615   39 KPAIRNqIIRELKVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPENILgKISIA-VLRGLTYLRE 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QH-IIHRDVKPDNILLDEQGHAHLTDFNIATIIKDgERATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYEL 171
Cdd:cd06615  118 KHkIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMSPERLQ-----GTHYTVQSDIWSLGLSLVEM 191

                 ....*.
gi 247269852 172 LRGWRP 177
Cdd:cd06615  192 AIGRYP 197
STKc_MSK1_C cd14179
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
2-223 4.13e-18

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK1 plays a role in the regulation of translational control and transcriptional activation. It phosphorylates the transcription factors, CREB and NFkB. It also phosphorylates the nucleosomal proteins H3 and HMG-14. Increased phosphorylation of MSK1 is associated with the development of cerebral ischemic/hypoxic preconditioning. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271081 [Multi-domain]  Cd Length: 310  Bit Score: 83.94  E-value: 4.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKqqcieRDEVrNVFRELEILQEIE-HVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14179   35 YAVKIVSK-----RMEA-NTQREIAALKLCEgHPNIVKLHEVYHDQLHTFLVMELLKGGELLERIKKKQHFSETEASHIM 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILL-DEQGHAHLT--DFNIATII-KDGERATALAGTKPYMAPEIFHSfvnggTGYS 156
Cdd:cd14179  109 RKLVSAVSHMHDVGVVHRDLKPENLLFtDESDNSEIKiiDFGFARLKpPDNQPLKTPCFTLHYAAPELLNY-----NGYD 183
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 157 FEVDWWSVGVMAYELLRGWRPYDIHS-----SNAVESLVQL----FSTVSVQYVPTwSKEMVALLRKLLTVNPEHR 223
Cdd:cd14179  184 ESCDLWSLGVILYTMLSGQVPFQCHDksltcTSAEEIMKKIkqgdFSFEGEAWKNV-SQEAKDLIQGLLTVDPNKR 258
STKc_TLK2 cd14041
Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2; STKs catalyze the ...
15-236 4.48e-18

Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TLKs play important functions during the cell cycle and are implicated in chromatin remodeling, DNA replication and repair, and mitosis. They phosphorylate and regulate Anti-silencing function 1 protein (Asf1), a histone H3/H4 chaperone that helps facilitate the assembly of chromatin following DNA replication during S phase. TLKs also phosphorylate the H3 histone tail and are essential in transcription. Vertebrates contain two subfamily members, TLK1 and TLK2. The TLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270943 [Multi-domain]  Cd Length: 309  Bit Score: 83.96  E-value: 4.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  15 RDEVRNVF-----RELEILQEIEHVFLVNLWYSFQDEEDMF-MVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALD 88
Cdd:cd14041   46 RDEKKENYhkhacREYRIHKELDHPRIVKLYDYFSLDTDSFcTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALK 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  89 YLRSQH--IIHRDVKPDNILL---DEQGHAHLTDFNIATIIKDG--------ERATALAGTKPYMAPEifhSFVNGGT-- 153
Cdd:cd14041  126 YLNEIKppIIHYDLKPGNILLvngTACGEIKITDFGLSKIMDDDsynsvdgmELTSQGAGTYWYLPPE---CFVVGKEpp 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 154 GYSFEVDWWSVGVMAYELLRGWRPYDIHSSNavESLVQ---LFSTVSVQY--VPTWSKEMVALLRKLLTVNPEHRFsSLQ 228
Cdd:cd14041  203 KISNKVDVWSVGVIFYQCLYGRKPFGHNQSQ--QDILQentILKATEVQFppKPVVTPEAKAFIRRCLAYRKEDRI-DVQ 279

                 ....*...
gi 247269852 229 DMQTAPSL 236
Cdd:cd14041  280 QLACDPYL 287
STKc_Nek11 cd08222
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
16-233 4.66e-18

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek11 is involved, through direct phosphorylation, in regulating the degradation of Cdc25A (Cell Division Cycle 25 homolog A), which plays a role in cell cycle progression and in activating cyclin dependent kinases. Nek11 is activated by CHK1 (CHeckpoint Kinase 1) and may be involved in the G2/M checkpoint. Nek11 may also play a role in the S-phase checkpoint as well as in DNA replication and genotoxic stress responses. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270861 [Multi-domain]  Cd Length: 260  Bit Score: 82.86  E-value: 4.66e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  16 DEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQ----FSEDTVRLYICEMALALDYLR 91
Cdd:cd08222   44 DETVDANREAKLLSKLDHPAIVKFHDSFVEKESFCIVTEYCEGGDLDDKISEYKKsgttIDENQILDWFIQLLLAVQYMH 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  92 SQHIIHRDVKPDNILLdEQGHAHLTDFNIATIIK-DGERATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYE 170
Cdd:cd08222  124 ERRILHRDLKAKNIFL-KNNVIKVGDFGISRILMgTSDLATTFTGTPYYMSPEVLK-----HEGYNSKSDIWSLGCILYE 197
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 247269852 171 LLRGWRPYDIHSSNAVesLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQTA 233
Cdd:cd08222  198 MCCLKHAFDGQNLLSV--MYKIVEGETPSLPDKYSKELNAIYSRMLNKDPALRPSAAEILKIP 258
STKc_16 cd13986
Catalytic domain of Serine/Threonine Kinase 16; STKs catalyze the transfer of the ...
1-223 5.21e-18

Catalytic domain of Serine/Threonine Kinase 16; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK16 is associated with many names including Myristylated and Palmitylated Serine/threonine Kinase 1 (MPSK1), Kinase related to cerevisiae and thaliana (Krct), and Protein Kinase expressed in day 12 fetal liver (PKL12). It is widely expressed in mammals with highest levels found in liver, testis, and kidney. It is localized in the Golgi but is translocated to the nucleus upon disorganization of the Golgi. STK16 is constitutively active and is capable of phosphorylating itself and other substrates. It may be involved in regulating stromal-epithelial interactions during mammary gland ductal morphogenesis. It may also function as a transcriptional co-activator of type-C natriuretic peptide and VEGF. The STK16 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270888 [Multi-domain]  Cd Length: 282  Bit Score: 83.11  E-value: 5.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKymnKQQCIERDEVRNVFRELEILQEIEHVFLVNLW-YSFQDEED----MFMVVDLLLGGDLRYHLQ----QNVQF 71
Cdd:cd13986   27 LYALK---KILCHSKEDVKEAMREIENYRLFNHPNILRLLdSQIVKEAGgkkeVYLLLPYYKRGSLQDEIErrlvKGTFF 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  72 SEDTVR---LYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDF---NIATI-IKDGERATALA------GTKP 138
Cdd:cd13986  104 PEDRILhifLGICRGLKAMHEPELVPYAHRDIKPGNVLLSEDDEPILMDLgsmNPARIeIEGRREALALQdwaaehCTMP 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 139 YMAPEIFHsfVNGGTGYSFEVDWWSVGVMAYELLRGWRPYD-IHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLT 217
Cdd:cd13986  184 YRAPELFD--VKSHCTIDEKTDIWSLGCTLYALMYGESPFErIFQKGDSLALAVLSGNYSFPDNSRYSEELHQLVKSMLV 261

                 ....*.
gi 247269852 218 VNPEHR 223
Cdd:cd13986  262 VNPAER 267
STKc_NIM1 cd14075
Catalytic domain of the Serine/Threonine Kinase, NIM1; STKs catalyze the transfer of the ...
3-231 6.18e-18

Catalytic domain of the Serine/Threonine Kinase, NIM1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NIM1 is a widely-expressed kinase belonging to the AMP-activated protein kinase (AMPK) subfamily. Although present in most tissues, NIM1 kinase activity is only observed in the brain and testis. NIM1 is capable of autophosphorylating and activating itself, but may be present in other tissues in the inactive form. The physiological function of NIM1 has yet to be elucidated. The NIM1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270977 [Multi-domain]  Cd Length: 255  Bit Score: 82.39  E-value: 6.18e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEvRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICE 82
Cdd:cd14075   31 AIKILDKTKLDQKTQ-RLLSREISSMEKLHHPNIIRLYEVVETLSKLHLVMEYASGGELYTKISTEGKLSESEAKPLFAQ 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFE-VDW 161
Cdd:cd14075  110 IVSAVKHMHENNIIHRDLKAENVFYASNNCVKVGDFGFSTHAKRGETLNTFCGSPPYAAPELFKD-----EHYIGIyVDI 184
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 247269852 162 WSVGVMAYELLRGWRPYdihSSNAVESLVQLFstVSVQY-VPTW-SKEMVALLRKLLTVNPEHRFsSLQDMQ 231
Cdd:cd14075  185 WALGVLLYFMVTGVMPF---RAETVAKLKKCI--LEGTYtIPSYvSEPCQELIRGILQPVPSDRY-SIDEIK 250
STKc_EIF2AK cd13996
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
2-228 8.04e-18

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. eIF-2 phosphorylation is induced in response to cellular stresses including virus infection, heat shock, nutrient deficiency, and the accummulation of unfolded proteins, among others. There are four distinct kinases that phosphorylate eIF-2 and control protein synthesis under different stress conditions: General Control Non-derepressible-2 (GCN2) which is activated during amino acid or serum starvation; protein kinase regulated by RNA (PKR) which is activated by double stranded RNA; heme-regulated inhibitor kinase (HRI) which is activated under heme-deficient conditions; and PKR-like endoplasmic reticulum kinase (PERK) which is activated when misfolded proteins accumulate in the ER. The EIF2AK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270898 [Multi-domain]  Cd Length: 273  Bit Score: 82.34  E-value: 8.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMK--YMNKQQCIERdevrNVFRELEILQEIEHVFLVNlWYSFQDEED-MFMVVDLLLGGDLRYHLQQ---NVQFSEDT 75
Cdd:cd13996   34 YAIKkiRLTEKSSASE----KVLREVKALAKLNHPNIVR-YYTAWVEEPpLYIQMELCEGGTLRDWIDRrnsSSKNDRKL 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  76 VRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQ-GHAHLTDFNIATIIKDGERATAL---------------AGTKPY 139
Cdd:cd13996  109 ALELFKQILKGVSYIHSKGIVHRDLKPSNIFLDNDdLQVKIGDFGLATSIGNQKRELNNlnnnnngntsnnsvgIGTPLY 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 140 MAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLrgwrpydiHSSNA----VESLVQLFSTVSVQYVPTWSKEMVALLRKL 215
Cdd:cd13996  189 ASPEQLD-----GENYNEKADIYSLGIILFEML--------HPFKTamerSTILTDLRNGILPESFKAKHPKEADLIQSL 255
                        250
                 ....*....|...
gi 247269852 216 LTVNPEHRFSSLQ 228
Cdd:cd13996  256 LSKNPEERPSAEQ 268
STKc_MEKK3_like_u1 cd06653
Catalytic domain of an Uncharacterized subfamily of Mitogen-Activated Protein (MAP) ...
17-178 8.34e-18

Catalytic domain of an Uncharacterized subfamily of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of uncharacterized proteins with similarity to MEKK3, MEKK2, and related proteins; they contain an N-terminal PB1 domain, which mediates oligomerization, and a C-terminal catalytic domain. MEKK2 and MEKK3 are MAPK kinase kinases (MAPKKKs or MKKKs), proteins that phosphorylate and activate MAPK kinases (MAPKKs or MKKs), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MEKK2 and MEKK3 activate MEK5 (also called MKK5), which activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. MEKK2 and MEKK3 can also activate the MAPKs, c-Jun N-terminal kinase (JNK) and p38, through their respective MAPKKs. The MEKK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270819 [Multi-domain]  Cd Length: 264  Bit Score: 82.38  E-value: 8.34e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  17 EVRNVFRELEILQEIEHVFLVNLWYSFQDEED--MFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQH 94
Cdd:cd06653   47 EVNALECEIQLLKNLRHDRIVQYYGCLRDPEEkkLSIFVEYMPGGSVKDQLKAYGALTENVTRRYTRQILQGVSYLHSNM 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  95 IIHRDVKPDNILLDEQGHAHLTDF----NIATIIKDGERATALAGTKPYMAPEIFhsfvnGGTGYSFEVDWWSVGVMAYE 170
Cdd:cd06653  127 IVHRDIKGANILRDSAGNVKLGDFgaskRIQTICMSGTGIKSVTGTPYWMSPEVI-----SGEGYGRKADVWSVACTVVE 201

                 ....*...
gi 247269852 171 LLRGWRPY 178
Cdd:cd06653  202 MLTEKPPW 209
STKc_p38beta cd07878
Catalytic domain of the Serine/Threonine Kinase, p38beta Mitogen-Activated Protein Kinase ...
19-174 1.03e-17

Catalytic domain of the Serine/Threonine Kinase, p38beta Mitogen-Activated Protein Kinase (also called MAPK11); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38beta/MAPK11 is widely expressed in tissues and shows more similarity with p38alpha than with the other isoforms. Both are sensitive to pyridinylimidazoles and share some common substrates such as MAPK activated protein kinase 2 (MK2) and the transcription factors ATF2, c-Fos and, ELK-1. p38beta is involved in regulating the activation of the cyclooxygenase-2 promoter and the expression of TGFbeta-induced alpha-smooth muscle cell actin. p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143383 [Multi-domain]  Cd Length: 343  Bit Score: 83.17  E-value: 1.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  19 RNVFRELEILQEIEHVFLVNLW------YSFQDEEDMFMVVDLLlGGDLRyHLQQNVQFSEDTVRLYICEMALALDYLRS 92
Cdd:cd07878   59 RRTYRELRLLKHMKHENVIGLLdvftpaTSIENFNEVYLVTNLM-GADLN-NIVKCQKLSDEHVQFLIYQLLRGLKYIHS 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILLDEQGHAHLTDFNIATiiKDGERATALAGTKPYMAPEIFHSFVNggtgYSFEVDWWSVGVMAYELL 172
Cdd:cd07878  137 AGIIHRDLKPSNVAVNEDCELRILDFGLAR--QADDEMTGYVATRWYRAPEIMLNWMH----YNQTVDIWSVGCIMAELL 210

                 ..
gi 247269852 173 RG 174
Cdd:cd07878  211 KG 212
STKc_MEKK1 cd06630
Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP) ...
14-223 1.09e-17

Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK1 is a MAPK kinase kinase (MAPKKK or MKKK) that phosphorylates and activates activates the ERK1/2 and c-Jun N-terminal kinase (JNK) pathways by activating their respective MAPKKs, MEK1/2 and MKK4/MKK7, respectively. MEKK1 is important in regulating cell survival and apoptosis. MEKK1 also plays a role in cell migration, tissue maintenance and homeostasis, and wound healing. The MEKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270800 [Multi-domain]  Cd Length: 268  Bit Score: 82.09  E-value: 1.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  14 ERDEV-RNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRS 92
Cdd:cd06630   42 EQEEVvEAIREEIRMMARLNHPNIVRMLGATQHKSHFNIFVEWMAGGSVASLLSKYGAFSENVIINYTLQILRGLAYLHD 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILLDEQG-HAHLTDFNIAT-----IIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGV 166
Cdd:cd06630  122 NQIIHRDLKGANLLVDSTGqRLRIADFGAAArlaskGTGAGEFQGQLLGTIAFMAPEVLR-----GEQYGRSCDVWSVGC 196
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 247269852 167 MAYELLRGWRPYDIHS-SNaveSLVQLFSTVSVQYVPTWSKEMVALLRKL----LTVNPEHR 223
Cdd:cd06630  197 VIIEMATAKPPWNAEKiSN---HLALIFKIASATTPPPIPEHLSPGLRDVtlrcLELQPEDR 255
STKc_CDKL1_4 cd07847
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4; ...
22-174 1.20e-17

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKL1, also called p42 KKIALRE, is a glial protein that is upregulated in gliosis. It is present in neuroblastoma and A431 human carcinoma cells, and may be implicated in neoplastic transformation. The function of CDKL4 is unknown. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL1/4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270837 [Multi-domain]  Cd Length: 286  Bit Score: 82.03  E-value: 1.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  22 FRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQNVQ-FSEDTVRLYICEMALALDYLRSQHIIHRDV 100
Cdd:cd07847   48 LREIRMLKQLKHPNLVNLIEVFRRKRKLHLVFEYC-DHTVLNELEKNPRgVPEHLIKKIIWQTLQAVNFCHKHNCIHRDV 126
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 247269852 101 KPDNILLDEQGHAHLTDFNIATIIKDGERA-TALAGTKPYMAPEIfhsfVNGGTGYSFEVDWWSVGVMAYELLRG 174
Cdd:cd07847  127 KPENILITKQGQIKLCDFGFARILTGPGDDyTDYVATRWYRAPEL----LVGDTQYGPPVDVWAIGCVFAELLTG 197
STKc_myosinIII_N_like cd06608
N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases; STKs catalyze ...
79-231 1.24e-17

N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class III myosins are motor proteins with an N-terminal kinase catalytic domain and a C-terminal actin-binding motor domain. Class III myosins are present in the photoreceptors of invertebrates and vertebrates and in the auditory hair cells of mammals. The kinase domain of myosin III can phosphorylate several cytoskeletal proteins, conventional myosin regulatory light chains, and can autophosphorylate the C-terminal motor domain. Myosin III may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. It may also function as a cargo carrier during light-dependent translocation, in photoreceptor cells, of proteins such as transducin and arrestin. The Drosophila class III myosin, called NinaC (Neither inactivation nor afterpotential protein C), is critical in normal adaptation and termination of photoresponse. Vertebrates contain two isoforms of class III myosin, IIIA and IIIB. This subfamily also includes mammalian NIK-like embryo-specific kinase (NESK), Traf2- and Nck-interacting kinase (TNIK), and mitogen-activated protein kinase (MAPK) kinase kinase kinase 4/6. MAP4Ks are involved in some MAPK signaling pathways by activating a MAPK kinase kinase. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The class III myosin-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270785 [Multi-domain]  Cd Length: 275  Bit Score: 81.96  E-value: 1.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YIC-EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKD--GERATALaGTKPYMAPEIFHSFVNGGTGY 155
Cdd:cd06608  117 YILrETLRGLAYLHENKVIHRDIKGQNILLTEEAEVKLVDFGVSAQLDStlGRRNTFI-GTPYWMAPEVIACDQQPDASY 195
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 156 SFEVDWWSVGVMAYELLRGWRPY-DIHSSNAvesLVQLFSTVSvqyvPT------WSKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd06608  196 DARCDVWSLGITAIELADGKPPLcDMHPMRA---LFKIPRNPP----PTlkspekWSKEFNDFISECLIKNYEQRPFTEE 268

                 ...
gi 247269852 229 DMQ 231
Cdd:cd06608  269 LLE 271
STK_BAK1_like cd14664
Catalytic domain of the Serine/Threonine Kinase, BRI1 associated kinase 1 and related STKs; ...
23-179 1.54e-17

Catalytic domain of the Serine/Threonine Kinase, BRI1 associated kinase 1 and related STKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes three leucine-rich repeat receptor-like kinases (LRR-RLKs): Arabidopsis thaliana BAK1 and CLAVATA1 (CLV1), and Physcomitrella patens CLL1B clavata1-like receptor S/T protein kinase. BAK1 functions in various signaling pathways. It plays a role in BR (brassinosteroid)-regulated plant development as a co-receptor of BRASSINOSTEROID (BR) INSENSITIVE 1 (BRI1), the receptor for BRs, and is required for full activation of BR signaling. It also modulates pathways involved in plant resistance to pathogen infection (pattern-triggered immunity, PTI) and herbivore attack (wound- or herbivore feeding-induced accumulation of jasmonic acid (JA) and JA-isoleucine. CLV1, directly binds small signaling peptides, CLAVATA3 (CLV3) and CLAVATA3/EMBRYO SURROUNDING REGI0N (CLE), to restrict stem cell proliferation: the CLV3-CLV1-WUS (WUSCHEL) module influences stem cell maintenance in the shoot apical meristem, and the CLE40 (CLAVATA3/EMBRYO SURROUNDING REGION40) -ACR4 (CRINKLY4) -CLV1- WOX5 (WUSCHEL-RELATED HOMEOBOX5) module at the root apical meristem. The STK_BAK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271134 [Multi-domain]  Cd Length: 270  Bit Score: 81.39  E-value: 1.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLL----LGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLR---SQHI 95
Cdd:cd14664   39 AEIQTLGMIRHRNIVRLRGYCSNPTTNLLVYEYMpngsLGELLHSRPESQPPLDWETRQRIALGSARGLAYLHhdcSPLI 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  96 IHRDVKPDNILLDEQGHAHLTDFNIATIIKDG--ERATALAGTKPYMAPEIFHsfvnggTGYSFE-VDWWSVGVMAYELL 172
Cdd:cd14664  119 IHRDVKSNNILLDEEFEAHVADFGLAKLMDDKdsHVMSSVAGSYGYIAPEYAY------TGKVSEkSDVYSYGVVLLELI 192

                 ....*..
gi 247269852 173 RGWRPYD 179
Cdd:cd14664  193 TGKRPFD 199
STKc_PLK3 cd14189
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3; STKs catalyze the ...
1-179 1.69e-17

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK3, also called Prk or Fnk (FGF-inducible kinase), regulates angiogenesis and responses to DNA damage. Activated PLK3 mediates Chk2 phosphorylation by ATM and the resulting checkpoint activation. PLK3 phosphorylates DNA polymerase delta and may be involved in DNA repair. It also inhibits Cdc25c, thereby regulating the onset of mitosis. The PLK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271091 [Multi-domain]  Cd Length: 255  Bit Score: 81.13  E-value: 1.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14189   28 TYAVKVIPHSRVAKPHQREKIVNEIELHRDLHHKHVVKFSHHFEDAENIYIFLELCSRKSLAHIWKARHTLLEPEVRYYL 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE-RATALAGTKPYMAPEIFHSfvnggTGYSFEV 159
Cdd:cd14189  108 KQIISGLKYLHLKGILHRDLKLGNFFINENMELKVGDFGLAARLEPPEqRKKTICGTPNYLAPEVLLR-----QGHGPES 182
                        170       180
                 ....*....|....*....|
gi 247269852 160 DWWSVGVMAYELLRGWRPYD 179
Cdd:cd14189  183 DVWSLGCVMYTLLCGNPPFE 202
STKc_TAO cd06607
Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins; STKs ...
4-226 1.88e-17

Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO proteins possess mitogen-activated protein kinase (MAPK) kinase kinase activity. They activate the MAPKs, p38 and c-Jun N-terminal kinase (JNK), by phosphorylating and activating the respective MAP/ERK kinases (MEKs, also known as MKKs or MAPKKs), MEK3/MEK6 and MKK4/MKK7. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. Vertebrates contain three TAO subfamily members, named TAO1, TAO2, and TAO3. The TAO subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270784 [Multi-domain]  Cd Length: 258  Bit Score: 80.96  E-value: 1.88e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   4 MKYMNKQQcieRDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLG--GDLRYHLQQNVQfsEDTVRLyIC 81
Cdd:cd06607   34 MSYSGKQS---TEKWQDIIKEVKFLRQLRHPNTIEYKGCYLREHTAWLVMEYCLGsaSDIVEVHKKPLQ--EVEIAA-IC 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMAL-ALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDgerATALAGTKPYMAPEIFHSFVNGgtGYSFEVD 160
Cdd:cd06607  108 HGALqGLAYLHSHNRIHRDVKAGNILLTEPGTVKLADFGSASLVCP---ANSFVGTPYWMAPEVILAMDEG--QYDGKVD 182
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 247269852 161 WWSVGVMAYELLRGWRPYdiHSSNAVESLVQLFSTVSvqyvPT-----WSKEMVALLRKLLTVNPEHRFSS 226
Cdd:cd06607  183 VWSLGITCIELAERKPPL--FNMNAMSALYHIAQNDS----PTlssgeWSDDFRNFVDSCLQKIPQDRPSA 247
STKc_RIP cd13978
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein; STKs catalyze ...
1-223 1.97e-17

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP kinases serve as essential sensors of cellular stress. They are involved in regulating NF-kappaB and MAPK signaling, and are implicated in mediating cellular processes such as apoptosis, necroptosis, differentiation, and survival. RIP kinases contain a homologous N-terminal kinase domain and varying C-terminal domains. Higher vertebrates contain multiple RIP kinases, with mammals harboring at least five members. RIP1 and RIP2 harbor C-terminal domains from the Death domain (DD) superfamily while RIP4 contains ankyrin (ANK) repeats. RIP3 contain a RIP homotypic interaction motif (RHIM) that facilitates binding to RIP1. RIP1 and RIP3 are important in apoptosis and necroptosis, while RIP2 and RIP4 play roles in keratinocyte differentiation and inflammatory immune responses. The RIP subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270880 [Multi-domain]  Cd Length: 263  Bit Score: 80.96  E-value: 1.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIErDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd13978   20 MVAIKCLHSSPNCI-EERKALLKEAEKMERARHSYVLPLLGVCVERRSLGLVMEYMENGSLKSLLEREIQDVPWSLRFRI 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 C-EMALALDYLRSQH--IIHRDVKPDNILLDEQGHAHLTDFNIA-----TIIKDGERATA-LAGTKPYMAPEIFHSFVNG 151
Cdd:cd13978   99 IhEIALGMNFLHNMDppLLHHDLKPENILLDNHFHVKISDFGLSklgmkSISANRRRGTEnLGGTPIYMAPEAFDDFNKK 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 152 GTGYSfevDWWSVGVMAYELLRGWRPYDihssNAVESLVQLFSTVSVQ----------YVPTWSKEMVALLRKLLTVNPE 221
Cdd:cd13978  179 PTSKS---DVYSFAIVIWAVLTRKEPFE----NAINPLLIMQIVSKGDrpslddigrlKQIENVQELISLMIRCWDGNPD 251

                 ..
gi 247269852 222 HR 223
Cdd:cd13978  252 AR 253
PKc_Wee1_like cd13997
Catalytic domain of the Wee1-like Protein Kinases; PKs catalyze the transfer of the ...
2-174 2.47e-17

Catalytic domain of the Wee1-like Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. This subfamily is composed of the dual-specificity kinase Myt1, the protein tyrosine kinase Wee1, and similar proteins. These proteins are cell cycle checkpoint kinases that are involved in the regulation of cyclin-dependent kinase CDK1, the master engine for mitosis. CDK1 is kept inactivated through phosphorylation of N-terminal thr (T14 by Myt1) and tyr (Y15 by Myt1 and Wee1) residues. Mitosis progression is ensured through activation of CDK1 by dephoshorylation and inactivation of Myt1/Wee1. The Wee1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270899 [Multi-domain]  Cd Length: 252  Bit Score: 80.51  E-value: 2.47e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVfRELEILQEI-EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQ---FSEDTVR 77
Cdd:cd13997   28 YAVKKSKKPFRGPKERARAL-REVEAHAALgQHPNIVRYYSSWEEGGHLYIQMELCENGSLQDALEELSPiskLSEAEVW 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  78 LYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIkdGERATALAGTKPYMAPEifhsFVNGGTGYSF 157
Cdd:cd13997  107 DLLLQVALGLAFIHSKGIVHLDIKPDNIFISNKGTCKIGDFGLATRL--ETSGDVEEGDSRYLAPE----LLNENYTHLP 180
                        170
                 ....*....|....*..
gi 247269852 158 EVDWWSVGVMAYELLRG 174
Cdd:cd13997  181 KADIFSLGVTVYEAATG 197
STKc_TBK1 cd13988
Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1; STKs catalyze the ...
1-218 3.54e-17

Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TBK1 is also called T2K and NF-kB-activating kinase. It is widely expressed in most cell types and acts as an IkappaB kinase (IKK)-activating kinase responsible for NF-kB activation in response to growth factors. It plays a role in modulating inflammatory responses through the NF-kB pathway. TKB1 is also a major player in innate immune responses since it functions as a virus-activated kinase necessary for establishing an antiviral state. It phosphorylates IRF-3 and IRF-7, which are important transcription factors for inducing type I interferon during viral infection. In addition, TBK1 may also play roles in cell transformation and oncogenesis. The TBK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270890 [Multi-domain]  Cd Length: 316  Bit Score: 81.38  E-value: 3.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRnvFRELEILQEIEHVFLVNLwysFQDEEDM-----FMVVDLLLGGDLRYHLQQNVQ---FS 72
Cdd:cd13988   20 LYAVKVFNNLSFMRPLDVQ--MREFEVLKKLNHKNIVKL---FAIEEELttrhkVLVMELCPCGSLYTVLEEPSNaygLP 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  73 EDTVRLYICEMALALDYLRSQHIIHRDVKPDNIL--LDEQGHA--HLTDFNIATIIKDGERATALAGTKPYMAPEIFHSF 148
Cdd:cd13988   95 ESEFLIVLRDVVAGMNHLRENGIVHRDIKPGNIMrvIGEDGQSvyKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 149 V---NGGTGYSFEVDWWSVGVMAYELLRG---WRPYDIHSSN-------------AVESLVQLFSTVSVQyvptWSKEMV 209
Cdd:cd13988  175 VlrkDHQKKYGATVDLWSIGVTFYHAATGslpFRPFEGPRRNkevmykiitgkpsGAISGVQKSENGPIE----WSGELP 250
                        250
                 ....*....|....*
gi 247269852 210 AL------LRKLLTV 218
Cdd:cd13988  251 VScslsqgLQTLLTP 265
STKc_BUR1 cd07866
Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase (CDK), ...
22-231 3.97e-17

Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase (CDK), Bypass UAS Requirement 1, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BUR1, also called SGV1, is a yeast CDK that is functionally equivalent to mammalian CDK9. It associates with the cyclin BUR2. BUR genes were orginally identified in a genetic screen as factors involved in general transcription. The BUR1/BUR2 complex phosphorylates the C-terminal domain of RNA polymerase II. In addition, this complex regulates histone modification by phosporylating Rad6 and mediating the association of the Paf1 complex with chromatin. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The BUR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270849 [Multi-domain]  Cd Length: 311  Bit Score: 81.21  E-value: 3.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  22 FRELEILQEIEH---VFLVNLWYSFQDEE-----DMFMV---VDLLLGGDLRyhlQQNVQFSEDTVRLYICEMALALDYL 90
Cdd:cd07866   55 LREIKILKKLKHpnvVPLIDMAVERPDKSkrkrgSVYMVtpyMDHDLSGLLE---NPSVKLTESQIKCYMLQLLEGINYL 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  91 RSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKD------------GERATALAGTKPYMAPEIfhsfVNGGTGYSFE 158
Cdd:cd07866  132 HENHILHRDIKAANILIDNQGILKIADFGLARPYDGpppnpkggggggTRKYTNLVVTRWYRPPEL----LLGERRYTTA 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGwRPY-----DIHSSNAVESLV--------QLFST--------VSVQYVPT-------WSKEMVA 210
Cdd:cd07866  208 VDIWGIGCVFAEMFTR-RPIlqgksDIDQLHLIFKLCgtpteetwPGWRSlpgcegvhSFTNYPRTleerfgkLGPEGLD 286
                        250       260
                 ....*....|....*....|.
gi 247269852 211 LLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd07866  287 LLSKLLSLDPYKRLTASDALE 307
STKc_EIF2AK2_PKR cd14047
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
8-223 4.48e-17

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Protein Kinase regulated by RNA; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKR (or EIF2AK2) contains an N-terminal double-stranded RNA (dsRNA) binding domain and a C-terminal catalytic kinase domain. It is activated by dsRNA, which is produced as a replication intermediate in virally infected cells. It plays a key role in mediating innate immune responses to viral infection. PKR is also directly activated by PACT (protein activator of PKR) and heparin, and is inhibited by viral proteins and RNAs. PKR also regulates transcription and signal transduction in diseased cells, playing roles in tumorigenesis and neurodegenerative diseases. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The PKR subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270949 [Multi-domain]  Cd Length: 267  Bit Score: 80.23  E-value: 4.48e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   8 NKQQCIERDEV--RNVFRELEILQEIEHVFLVNLWYSFQDEEDM----------------FMVVDLLLGGDL-------- 61
Cdd:cd14047   31 GKTYAIKRVKLnnEKAEREVKALAKLDHPNIVRYNGCWDGFDYDpetsssnssrsktkclFIQMEFCEKGTLeswiekrn 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  62 ---RYHLQQNVQFSEdtvrlyiceMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKP 138
Cdd:cd14047  111 gekLDKVLALEIFEQ---------ITKGVEYIHSKKLIHRDLKPSNIFLVDTGKVKIGDFGLVTSLKNDGKRTKSKGTLS 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 139 YMAPEIFhsfvnGGTGYSFEVDWWSVGVMAYELLrgWRPYDIHSSNAVESLVQlFSTVSVQYVPTWSKEmVALLRKLLTV 218
Cdd:cd14047  182 YMSPEQI-----SSQDYGKEVDIYALGLILFELL--HVCDSAFEKSKFWTDLR-NGILPDIFDKRYKIE-KTIIKKMLSK 252

                 ....*
gi 247269852 219 NPEHR 223
Cdd:cd14047  253 KPEDR 257
STKc_Sty1_Hog1 cd07856
Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases ...
19-238 5.21e-17

Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases Sty1 and Hog1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPKs Sty1 from Schizosaccharomyces pombe, Hog1 from Saccharomyces cerevisiae, and similar proteins. Sty1 and Hog1 are stress-activated MAPKs that partipate in transcriptional regulation in response to stress. Sty1 is activated in response to oxidative stress, osmotic stress, and UV radiation. It is regulated by the MAP2K Wis1, which is activated by the MAP3Ks Wis4 and Win1, which receive signals of the stress condition from membrane-spanning histidine kinases Mak1-3. Activated Sty1 stabilizes the Atf1 transcription factor and induces transcription of Atf1-dependent genes of the core environmetal stress response. Hog1 is the key element in the high osmolarity glycerol (HOG) pathway and is activated upon hyperosmotic stress. Activated Hog1 accumulates in the nucleus and regulates stress-induced transcription. The HOG pathway is mediated by two transmembrane osmosensors, Sln1 and Sho1. MAPKs are important mediators of cellular responses to extracellular signals. The Sty1/Hog1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270843 [Multi-domain]  Cd Length: 328  Bit Score: 81.08  E-value: 5.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  19 RNVFRELEILQEIEHVFLVNLWYSF-QDEEDMFMVVDLLlGGDLrYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIH 97
Cdd:cd07856   54 KRTYRELKLLKHLRHENIISLSDIFiSPLEDIYFVTELL-GTDL-HRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVIH 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  98 RDVKPDNILLDEQGHAHLTDFNIATIikDGERATALAGTKPYMAPEIFHSFvnggTGYSFEVDWWSVGVMAYELLRGwRP 177
Cdd:cd07856  132 RDLKPSNILVNENCDLKICDFGLARI--QDPQMTGYVSTRYYRAPEIMLTW----QKYDVEVDIWSAGCIFAEMLEG-KP 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 178 Y--------------------------DIHSSNA---VESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSlq 228
Cdd:cd07856  205 LfpgkdhvnqfsiitellgtppddvinTICSENTlrfVQSLPKRERVPFSEKFKNADPDAIDLLEKMLVFDPKKRISA-- 282
                        250
                 ....*....|
gi 247269852 229 dmqtAPSLAH 238
Cdd:cd07856  283 ----AEALAH 288
STKc_DRAK1 cd14197
Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
2-231 6.06e-17

Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 (also called STK17A) and DRAK2. Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. Rabbit DRAK1 has been shown to induce apoptosis in osteoclasts and overexpressio of human DRAK1 induces apoptosis in cultured fibroblast cells. DRAK1 may be involved in apoptotic signaling. The DRAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271099 [Multi-domain]  Cd Length: 271  Bit Score: 79.98  E-value: 6.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNK----QQCieRDEVRNVFRELEILQEieHVFLVNLWYSFQDEEDMFMVVDLLLGGDL--RYHLQQNVQFSEDT 75
Cdd:cd14197   37 FAAKFMRKrrkgQDC--RMEIIHEIAVLELAQA--NPWVINLHEVYETASEMILVLEYAAGGEIfnQCVADREEAFKEKD 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  76 VRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQ---GHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSfvngg 152
Cdd:cd14197  113 VKRLMKQILEGVSFLHNNNVVHLDLKPQNILLTSEsplGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSY----- 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 153 TGYSFEVDWWSVGVMAYELLRGWRPY-DIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd14197  188 EPISTATDMWSIGVLAYVMLTGISPFlGDDKQETFLNISQMNVSYSEEEFEHLSESAIDFIKTLLIKKPENRATAEDCLK 267
PTKc_Wee1_fungi cd14052
Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins; PTKs catalyze the ...
2-170 8.74e-17

Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of fungal Wee1 proteins, also called Swe1 in budding yeast and Mik1 in fission yeast. Yeast Wee1 is required to control cell size. Wee1 is a cell cycle checkpoint kinase that helps keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of an N-terminal tyr (Y15) residue. During the late G2 phase, CDK1 is activated and mitotic entry is promoted by the removal of this inhibitory phosphorylation by the phosphatase Cdc25. Although Wee1 is functionally a tyr kinase, it is more closely related to serine/threonine kinases (STKs). It contains a catalytic kinase domain sandwiched in between N- and C-terminal regulatory domains. It is regulated by phosphorylation and degradation, and its expression levels are also controlled by circadian clock proteins. The fungal Wee1 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, other PTKs, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270954 [Multi-domain]  Cd Length: 278  Bit Score: 79.39  E-value: 8.74e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVfRELEILQEIE---HVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSE-DTVR 77
Cdd:cd14052   29 YAVKKLKPNYAGAKDRLRRL-EEVSILRELTldgHDNIVQLIDSWEYHGHLYIQTELCENGSLDVFLSELGLLGRlDEFR 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  78 LY--ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDgERATALAGTKPYMAPEIFhsfvnGGTGY 155
Cdd:cd14052  108 VWkiLVELSLGLRFIHDHHFVHLDLKPANVLITFEGTLKIGDFGMATVWPL-IRGIEREGDREYIAPEIL-----SEHMY 181
                        170
                 ....*....|....*
gi 247269852 156 SFEVDWWSVGVMAYE 170
Cdd:cd14052  182 DKPADIFSLGLILLE 196
STKc_p38 cd07851
Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase; STKs ...
19-231 8.74e-17

Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. They function in the regulation of the cell cycle, cell development, cell differentiation, senescence, tumorigenesis, apoptosis, pain development and pain progression, and immune responses. p38 kinases are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. p38 substrates include other protein kinases and factors that regulate transcription, nuclear export, mRNA stability and translation. p38 kinases are drug targets for the inflammatory diseases psoriasis, rheumatoid arthritis, and chronic pulmonary disease. Vertebrates contain four isoforms of p38, named alpha, beta, gamma, and delta, which show varying substrate specificity and expression patterns. p38alpha and p38beta are ubiquitously expressed, p38gamma is predominantly found in skeletal muscle, and p38delta is found in the heart, lung, testis, pancreas, and small intestine. The p38 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143356 [Multi-domain]  Cd Length: 343  Bit Score: 80.42  E-value: 8.74e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  19 RNVFRELEILQEIEH---VFLVNLWY---SFQDEEDMFMVVDLLlGGDLrYHLQQNVQFSEDTVRLYICEMALALDYLRS 92
Cdd:cd07851   59 KRTYRELRLLKHMKHenvIGLLDVFTpasSLEDFQDVYLVTHLM-GADL-NNIVKCQKLSDDHIQFLVYQILRGLKYIHS 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILLDEQGHAHLTDFNIATiiKDGERATALAGTKPYMAPEIFHSFVNggtgYSFEVDWWSVGVMAYELL 172
Cdd:cd07851  137 AGIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVATRWYRAPEIMLNWMH----YNQTVDIWSVGCIMAELL 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 173 ------RGWRPYD-------------------IHSSNA---VESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRF 224
Cdd:cd07851  211 tgktlfPGSDHIDqlkrimnlvgtpdeellkkISSESArnyIQSLPQMPKKDFKEVFSGANPLAIDLLEKMLVLDPDKRI 290

                 ....*..
gi 247269852 225 SSLQDMQ 231
Cdd:cd07851  291 TAAEALA 297
PKc_PBS2_like cd06622
Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases; ...
13-223 9.21e-17

Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Polymyxin B resistance protein 2 (PBS2) from Saccharomyces cerevisiae, Wis1 from Schizosaccharomyces pombe, and related proteins. PBS2 and Wis1 are components of stress-activated MAPK cascades in budding and fission yeast, respectively. PBS2 is the specific activator of the MAPK Hog1, which plays a central role in the response of budding yeast to stress including exposure to arsenite and hyperosmotic environments. Wis1 phosphorylates and activates the MAPK Sty1 (also called Spc1 or Phh1), which stimulates a transcriptional response to a wide range of cellular insults through the bZip transcription factors Atf1, Pcr1, and Pap1. The PBS2 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132953 [Multi-domain]  Cd Length: 286  Bit Score: 79.51  E-value: 9.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  13 IERDE--VRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFS---EDTVRLYICEMALAL 87
Cdd:cd06622   36 LELDEskFNQIIMELDILHKAVSPYIVDFYGAFFIEGAVYMCMEYMDAGSLDKLYAGGVATEgipEDVLRRITYAVVKGL 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  88 DYLRSQH-IIHRDVKPDNILLDEQGHAHLTDFNIAtiikdGERATALA----GTKPYMAPEIFHSF-VNGGTGYSFEVDW 161
Cdd:cd06622  116 KFLKEEHnIIHRDVKPTNVLVNGNGQVKLCDFGVS-----GNLVASLAktniGCQSYMAPERIKSGgPNQNPTYTVQSDV 190
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 247269852 162 WSVGVMAYELLRGWRPYDIHSSNAVESlvQLFSTVS---VQYVPTWSKEMVALLRKLLTVNPEHR 223
Cdd:cd06622  191 WSLGLSILEMALGRYPYPPETYANIFA--QLSAIVDgdpPTLPSGYSDDAQDFVAKCLNKIPNRR 253
STKc_TAO3 cd06633
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3; STKs catalyze ...
4-228 9.58e-17

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO3 is also known as JIK (c-Jun N-terminal kinase inhibitory kinase) or KFC (kinase from chicken). It specifically activates JNK, presumably by phosphorylating and activating MKK4/MKK7. In Saccharomyces cerevisiae, TAO3 is a component of the RAM (regulation of Ace2p activity and cellular morphogenesis) signaling pathway. TAO3 is upregulated in retinal ganglion cells after axotomy, and may play a role in apoptosis. TAO proteins possess mitogen-activated protein kinase (MAPK) kinase kinase activity. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The TAO3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270803 [Multi-domain]  Cd Length: 313  Bit Score: 80.08  E-value: 9.58e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   4 MKYMNKQQcieRDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGD---LRYHLQ--QNVQFSEdtvrl 78
Cdd:cd06633   54 MSYSGKQT---NEKWQDIIKEVKFLQQLKHPNTIEYKGCYLKDHTAWLVMEYCLGSAsdlLEVHKKplQEVEIAA----- 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 yICEMAL-ALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDgerATALAGTKPYMAPEIFHSFVNGgtGYSF 157
Cdd:cd06633  126 -ITHGALqGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASIASP---ANSFVGTPYWMAPEVILAMDEG--QYDG 199
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 158 EVDWWSVGVMAYELLRgwRPYDIHSSNAVESLVQLFSTVSvqyvPT-----WSKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd06633  200 KVDIWSLGITCIELAE--RKPPLFNMNAMSALYHIAQNDS----PTlqsneWTDSFRGFVDYCLQKIPQERPSSAE 269
STKc_CDK4_6_like cd07838
Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases; ...
20-231 1.04e-16

Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK4 and CDK6 partner with D-type cyclins to regulate the early G1 phase of the cell cycle. They are the first kinases activated by mitogenic signals to release cells from the G0 arrested state. CDK4 and CDK6 are both expressed ubiquitously, associate with all three D cyclins (D1, D2 and D3), and phosphorylate the retinoblastoma (pRb) protein. They are also regulated by the INK4 family of inhibitors which associate with either the CDK alone or the CDK/cyclin complex. CDK4 and CDK6 show differences in subcellular localization, sensitivity to some inhibitors, timing in activation, tumor selectivity, and possibly substrate profiles. Although CDK4 and CDK6 seem to show some redundancy, they also have discrete, nonoverlapping functions. CDK6 plays an important role in cell differentiation. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK4/6-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270831 [Multi-domain]  Cd Length: 287  Bit Score: 79.63  E-value: 1.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  20 NVFRELEILQEIEH------VFLVNLWYSFQDEE--DMFMV---VDlllgGDLRYHLQQNVQ--FSEDTVRLYICEMALA 86
Cdd:cd07838   44 STIREIALLKQLESfehpnvVRLLDVCHGPRTDRelKLTLVfehVD----QDLATYLDKCPKpgLPPETIKDLMRQLLRG 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  87 LDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGV 166
Cdd:cd07838  120 LDFLHSHRIVHRDLKPQNILVTSDGQVKLADFGLARIYSFEMALTSVVVTLWYRAPEVLL-----QSSYATPVDMWSVGC 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 167 MAYELLRgWRPYdIHSSNAVESLVQLFS------------TVSV------QY--------VPTWSKEMVALLRKLLTVNP 220
Cdd:cd07838  195 IFAELFN-RRPL-FRGSSEADQLGKIFDviglpseeewprNSALprssfpSYtprpfksfVPEIDEEGLDLLKKMLTFNP 272
                        250
                 ....*....|.
gi 247269852 221 EHRFSSLQDMQ 231
Cdd:cd07838  273 HKRISAFEALQ 283
STKc_MEKK2 cd06652
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular ...
17-178 1.35e-16

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK2 is a MAPK kinase kinase (MAPKKK or MKKK), that phosphorylates and activates the MAPK kinase MEK5 (or MKK5), which in turn phosphorylates and activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK2 also activates ERK1/2, c-Jun N-terminal kinase (JNK) and p38 through their respective MAPKKs MEK1/2, JNK-activating kinase 2 (JNKK2), and MKK3/6. MEKK2 plays roles in T cell receptor signaling, immune synapse formation, cytokine gene expression, as well as in EGF and FGF receptor signaling. The MEKK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270818 [Multi-domain]  Cd Length: 264  Bit Score: 78.93  E-value: 1.35e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  17 EVRNVFRELEILQEIEHVFLVNLWYSFQD--EEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQH 94
Cdd:cd06652   47 EVNALECEIQLLKNLLHERIVQYYGCLRDpqERTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVHYLHSNM 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  95 IIHRDVKPDNILLDEQGHAHLTDFN----IATIIKDGERATALAGTKPYMAPEIFhsfvnGGTGYSFEVDWWSVGVMAYE 170
Cdd:cd06652  127 IVHRDIKGANILRDSVGNVKLGDFGaskrLQTICLSGTGMKSVTGTPYWMSPEVI-----SGEGYGRKADIWSVGCTVVE 201

                 ....*...
gi 247269852 171 LLRGWRPY 178
Cdd:cd06652  202 MLTEKPPW 209
STKc_MAP4K5 cd06646
Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase ...
16-223 1.35e-16

Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP4K5, also called germinal center kinase-related enzyme (GCKR), has been shown to activate the MAPK c-Jun N-terminal kinase (JNK). MAP4K5 also facilitates Wnt signaling in B cells, and may therefore be implicated in the control of cell fate, proliferation, and polarity. MAP4Ks are involved in some MAPK signaling pathways by activating a MAPK kinase kinase. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. The MAP4K5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270813 [Multi-domain]  Cd Length: 268  Bit Score: 78.92  E-value: 1.35e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  16 DEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLR--YHLQQnvQFSEDTVRlYICEMAL-ALDYLRS 92
Cdd:cd06646   48 DDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQdiYHVTG--PLSELQIA-YVCRETLqGLAYLHS 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILLDEQGHAHLTDFNIAT-IIKDGERATALAGTKPYMAPEIFHSFVNGgtGYSFEVDWWSVGVMAYEL 171
Cdd:cd06646  125 KGKMHRDIKGANILLTDNGDVKLADFGVAAkITATIAKRKSFIGTPYWMAPEVAAVEKNG--GYNQLCDIWAVGITAIEL 202
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 247269852 172 LRGWRP-YDIHSSNAVESLVQL-FSTVSVQYVPTWSKEMVALLRKLLTVNPEHR 223
Cdd:cd06646  203 AELQPPmFDLHPMRALFLMSKSnFQPPKLKDKTKWSSTFHNFVKISLTKNPKKR 256
STKc_obscurin_rpt2 cd14110
Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs ...
21-231 1.66e-16

Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Obscurin, approximately 800 kDa in size, is one of three giant proteins expressed in vetebrate striated muscle, together with titin and nebulin. It is a multidomain protein composed of tandem adhesion and signaling domains, including 49 immunoglobulin (Ig) and 2 fibronectin type III (FN3) domains at the N-terminus followed by a more complex region containing more Ig domains, a conserved SH3 domain near a RhoGEF and PH domains, non-modular regions, as well as IQ and phosphorylation motifs. The obscurin gene also encode two kinase domains, which are not expressed as part of the 800 kDa protein, but as a smaller, alternatively spliced product present mainly in the heart muscle, also called obscurin-MLCK. Obscurin is localized at the peripheries of Z-disks and M-lines, where it is able to communicate with the surrounding myoplasm. It interacts with diverse proteins including sAnk1, myosin, titin, and MyBP-C. It may act as a scaffold for the assembly of elements of the contractile apparatus. The obscurin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271012 [Multi-domain]  Cd Length: 257  Bit Score: 78.42  E-value: 1.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  21 VFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDV 100
Cdd:cd14110   46 VLREYQVLRRLSHPRIAQLHSAYLSPRHLVLIEELCSGPELLYNLAERNSYSEAEVTDYLWQILSAVDYLHSRRILHLDL 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 101 KPDNILLDEQGHAHLTDFNIATIIKDGeRATALAGTKPY---MAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLRGwrP 177
Cdd:cd14110  126 RSENMIITEKNLLKIVDLGNAQPFNQG-KVLMTDKKGDYvetMAPELLE-----GQGAGPQTDIWAIGVTAFIMLSA--D 197
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 247269852 178 YDIHSSNAVE-------SLVQLfstvSVQYvPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd14110  198 YPVSSDLNWErdrnirkGKVQL----SRCY-AGLSGGAVNFLKSTLCAKPWGRPTASECLQ 253
STKc_CDK1_CdkB_like cd07835
Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of ...
23-231 1.84e-16

Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of Plant B-type Cyclin-Dependent protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK, CDK2, and CDK3. CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression while the CDK1/cyclin B complex is critical for G2 to M phase transition. CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. The CDK2/cyclin A complex plays a role in regulating DNA replication. Studies in knockout mice revealed that CDK1 can compensate for the loss of the cdk2 gene as it can also bind cyclin E and drive G1 to S phase transition. CDK3 is regulated by cyclin C and it phosphorylates pRB specifically during the G0/G1 transition. This phosphorylation is required for cells to exit G0 efficiently and enter the G1 phase. The plant-specific B-type CDKs are expressed from the late S to the M phase of the cell cycle. They are characterized by the cyclin binding motif PPT[A/T]LRE. They play a role in controlling mitosis and integrating developmental pathways, such as stomata and leaf development. CdkB has been shown to associate with both cyclin B, which controls G2/M transition, and cyclin D, which acts as a mediator in linking extracellular signals to the cell cycle. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270829 [Multi-domain]  Cd Length: 283  Bit Score: 78.49  E-value: 1.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQ--NVQFSEDTVRLYICEMALALDYLRSQHIIHRDV 100
Cdd:cd07835   47 REISLLKELNHPNIVRLLDVVHSENKLYLVFEFL-DLDLKKYMDSspLTGLDPPLIKSYLYQLLQGIAFCHSHRVLHRDL 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 101 KPDNILLDEQGHAHLTDFNIATIIKDGERA-TALAGTKPYMAPEIFHsfvnGGTGYSFEVDWWSVGVMAYELLRGwRPYd 179
Cdd:cd07835  126 KPQNLLIDTEGALKLADFGLARAFGVPVRTyTHEVVTLWYRAPEILL----GSKHYSTPVDIWSVGCIFAEMVTR-RPL- 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 180 IHSSNAVESLVQLFSTVSV----------------------------QYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd07835  200 FPGDSEIDQLFRIFRTLGTpdedvwpgvtslpdykptfpkwarqdlsKVVPSLDEDGLDLLSQMLVYDPAKRISAKAALQ 279
STKc_ERK5 cd07855
Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5; ...
19-231 2.57e-16

Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ERK5 (also called Big MAPK1 (BMK1) or MAPK7) has a unique C-terminal extension, making it approximately twice as big as other MAPKs. This extension contains transcriptional activation capability which is inhibited by the N-terminal half. ERK5 is activated in response to growth factors and stress by a cascade that leads to its phosphorylation by the MAP2K MEK5, which in turn is regulated by the MAP3Ks MEKK2 and MEKK3. Activated ERK5 phosphorylates its targets including myocyte enhancer factor 2 (MEF2), Sap1a, c-Myc, and RSK. It plays a role in EGF-induced cell proliferation during the G1/S phase transition. Studies on knockout mice revealed that ERK5 is essential for cardiovascular development and plays an important role in angiogenesis. It is also critical for neural differentiation and survival. The ERK5 pathway has been implicated in the pathogenesis of many diseases including cancer, cardiac hypertrophy, and atherosclerosis. MAPKs are important mediators of cellular responses to extracellular signals. The ERK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270842 [Multi-domain]  Cd Length: 336  Bit Score: 78.95  E-value: 2.57e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  19 RNVFRELEILQEIEHVFLVNLWYSFQ------DEEDMFMVVDLLlGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRS 92
Cdd:cd07855   49 KRTLRELKILRHFKHDNIIAIRDILRpkvpyaDFKDVYVVLDLM-ESDLHHIIHSDQPLTLEHIRYFLYQLLRGLKYIHS 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILLDEQGHAHLTDFNIATII----KDGER-ATALAGTKPYMAPEIFHSFvnggTGYSFEVDWWSVGVM 167
Cdd:cd07855  128 ANVIHRDLKPSNLLVNENCELKIGDFGMARGLctspEEHKYfMTEYVATRWYRAPELMLSL----PEYTQAIDMWSVGCI 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 168 AYELLrGWRP--------YDIH-----------------SSNAVESLVQLFSTVSV----QYVPTWSKEMVALLRKLLTV 218
Cdd:cd07855  204 FAEML-GRRQlfpgknyvHQLQliltvlgtpsqavinaiGADRVRRYIQNLPNKQPvpweTLYPKADQQALDLLSQMLRF 282
                        250
                 ....*....|...
gi 247269852 219 NPEHRFSSLQDMQ 231
Cdd:cd07855  283 DPSERITVAEALQ 295
STKc_PRP4 cd14135
Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4; STKs catalyze ...
23-174 2.88e-16

Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PRP4 phosphorylates a number of factors involved in the formation of active spliceosomes, which catalyze pre-mRNA splicing. It phosphorylates PRP6 and PRP31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), during spliceosomal complex formation. In fission yeast, PRP4 phosphorylates the splicing factor PRP1 (U5-102 kD in mammals). Thus, PRP4 plays a key role in regulating spliceosome assembly and pre-mRNA splicing. It also plays an important role in mitosis by acting as a spindle assembly checkpoint kinase that is required for chromosome alignment and the recruitment of the checkpoint proteins MPS1, MAD1, and MAD2 at kinetochores. The PRP4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271037 [Multi-domain]  Cd Length: 318  Bit Score: 78.42  E-value: 2.88e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEI--------EHVflVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQ---QNVQFSEDTVRLYICEMALALDYLR 91
Cdd:cd14135   46 KELEILKKLndadpddkKHC--IRLLRHFEHKNHLCLVFESL-SMNLREVLKkygKNVGLNIKAVRSYAQQLFLALKHLK 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  92 SQHIIHRDVKPDNILLDEQGHA-HLTDFNIATIIKDGERATALAgTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYE 170
Cdd:cd14135  123 KCNILHADIKPDNILVNEKKNTlKLCDFGSASDIGENEITPYLV-SRFYRAPEIIL-----GLPYDYPIDMWSVGCTLYE 196

                 ....
gi 247269852 171 LLRG 174
Cdd:cd14135  197 LYTG 200
STKc_p38gamma cd07880
Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase ...
19-251 3.32e-16

Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38gamma/MAPK12 is predominantly expressed in skeletal muscle. Unlike p38alpha and p38beta, p38gamma is insensitive to pyridinylimidazoles. It displays an antagonizing function compared to p38alpha. p38gamma inhibits, while p38alpha stimulates, c-Jun phosphorylation and AP-1 mediated transcription. p38gamma also plays a role in the signaling between Ras and the estrogen receptor and has been implicated to increase cell invasion and breast cancer progression. In Xenopus, p38gamma is critical in the meiotic maturation of oocytes. p38 kinases are MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38gamma subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143385 [Multi-domain]  Cd Length: 343  Bit Score: 78.84  E-value: 3.32e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  19 RNVFRELEILQEIEHVFLVNLWYSFQDEEDM-----FMVVDLLLGGDLRyHLQQNVQFSEDTVRLYICEMALALDYLRSQ 93
Cdd:cd07880   59 KRAYRELRLLKHMKHENVIGLLDVFTPDLSLdrfhdFYLVMPFMGTDLG-KLMKHEKLSEDRIQFLVYQMLKGLKYIHAA 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  94 HIIHRDVKPDNILLDEQGHAHLTDFNIATiIKDGErATALAGTKPYMAPEIFHSFVNggtgYSFEVDWWSVGVMAYELLR 173
Cdd:cd07880  138 GIIHRDLKPGNLAVNEDCELKILDFGLAR-QTDSE-MTGYVVTRWYRAPEVILNWMH----YTQTVDIWSVGCIMAEMLT 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 174 GwRP--------------YDIHSSNAVESLVQLFSTVSVQYV---------------PTWSKEMVALLRKLLTVNPEHRF 224
Cdd:cd07880  212 G-KPlfkghdhldqlmeiMKVTGTPSKEFVQKLQSEDAKNYVkklprfrkkdfrsllPNANPLAVNVLEKMLVLDAESRI 290
                        250       260
                 ....*....|....*....|....*..
gi 247269852 225 SSlqdmqtAPSLAHVLWDDLSEKKVEP 251
Cdd:cd07880  291 TA------AEALAHPYFEEFHDPEDET 311
STKc_DRAK2 cd14198
The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
2-223 4.36e-16

The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 and DRAK2 (also called STK17B). Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. DRAK2 has been implicated in inducing or enhancing apoptosis in beta cells, fibroblasts, and lymphoid cells, where it is highly expressed. It is involved in regulating many immune processes including the germinal center (GC) reaction, responses to thymus-dependent antigens, activated T cell survival, memory T cell responses. It may be involved in the development of autoimmunity. The DRAK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271100 [Multi-domain]  Cd Length: 270  Bit Score: 77.27  E-value: 4.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNK----QQCieRDEVRNVFRELEILQEIEHVflVNLWYSFQDEEDMFMVVDLLLGGDLRYHL--QQNVQFSEDT 75
Cdd:cd14198   36 YAAKFLKKrrrgQDC--RAEILHEIAVLELAKSNPRV--VNLHEVYETTSEIILILEYAAGGEIFNLCvpDLAEMVSEND 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  76 VRLYICEMALALDYLRSQHIIHRDVKPDNILLDE---QGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIF-HSFVNG 151
Cdd:cd14198  112 IIRLIRQILEGVYYLHQNNIVHLDLKPQNILLSSiypLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILnYDPITT 191
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 152 GTgysfevDWWSVGVMAYELLRGWRPYdiHSSNAVESLVQLfSTVSVQY----VPTWSKEMVALLRKLLTVNPEHR 223
Cdd:cd14198  192 AT------DMWNIGVIAYMLLTHESPF--VGEDNQETFLNI-SQVNVDYseetFSSVSQLATDFIQKLLVKNPEKR 258
STKc_MAP4K4_6_N cd06636
N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase ...
3-228 5.15e-16

N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4K4 is also called Nck Interacting kinase (NIK). It facilitates the activation of the MAPKs, extracellular signal-regulated kinase (ERK) 1, ERK2, and c-Jun N-terminal kinase (JNK), by phosphorylating and activating MEKK1. MAP4K4 plays a role in tumor necrosis factor (TNF) alpha-induced insulin resistance. MAP4K4 silencing in skeletal muscle cells from type II diabetic patients restores insulin-mediated glucose uptake. MAP4K4, through JNK, also plays a broad role in cell motility, which impacts inflammation, homeostasis, as well as the invasion and spread of cancer. MAP4K4 is found to be highly expressed in most tumor cell lines relative to normal tissue. MAP4K6 (also called MINK for Misshapen/NIKs-related kinase) is activated after Ras induction and mediates activation of p38 MAPK. MAP4K6 plays a role in cell cycle arrest, cytoskeleton organization, cell adhesion, and cell motility. The MAP4K4/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270806 [Multi-domain]  Cd Length: 282  Bit Score: 77.35  E-value: 5.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNkqqcIERDEVRNVFRELEILQEIEHVFLVNLWY------SFQDEEDMFMVVDLLLGGDLRYHLQQNVQ---FSE 73
Cdd:cd06636   45 AIKVMD----VTEDEEEEIKLEINMLKKYSHHRNIATYYgafikkSPPGHDDQLWLVMEFCGAGSVTDLVKNTKgnaLKE 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  74 DTVRlYIC-EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNI-ATIIKDGERATALAGTKPYMAPEIFHSFVNG 151
Cdd:cd06636  121 DWIA-YICrEILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVsAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 199
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 152 GTGYSFEVDWWSVGVMAYELLRGWRPY-DIHSSNAVeSLVQLFSTVSVQyVPTWSKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd06636  200 DATYDYRSDIWSLGITAIEMAEGAPPLcDMHPMRAL-FLIPRNPPPKLK-SKKWSKKFIDFIEGCLVKNYLSRPSTEQ 275
PLN00034 PLN00034
mitogen-activated protein kinase kinase; Provisional
2-231 7.73e-16

mitogen-activated protein kinase kinase; Provisional


Pssm-ID: 215036 [Multi-domain]  Cd Length: 353  Bit Score: 77.94  E-value: 7.73e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMK--YMNKQqcierDEVRN-VFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRL 78
Cdd:PLN00034 102 YALKviYGNHE-----DTVRRqICREIEILRDVNHPNVVKCHDMFDHNGEIQVLLEFMDGGSLEGTHIADEQFLADVARQ 176
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMAlaldYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDG-ERATALAGTKPYMAPEIFHSFVNGGTGYSF 157
Cdd:PLN00034 177 ILSGIA----YLHRRHIVHRDIKPSNLLINSAKNVKIADFGVSRILAQTmDPCNSSVGTIAYMSPERINTDLNHGAYDGY 252
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 247269852 158 EVDWWSVGVMAYELLRGWRPYDIHSSNAVESLV-QLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:PLN00034 253 AGDIWSLGVSILEFYLGRFPFGVGRQGDWASLMcAICMSQPPEAPATASREFRHFISCCLQREPAKRWSAMQLLQ 327
STKc_PCTAIRE1 cd07873
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase; STKs catalyze the transfer ...
23-204 8.81e-16

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-1 is expressed ubiquitously and is localized in the cytoplasm. Its kinase activity is cell cycle dependent and peaks at the S and G2 phases. PCTAIRE-1 is highly expressed in the brain and may play a role in regulating neurite outgrowth. It can also associate with Trap (Tudor repeat associator with PCTAIRE-2), a physiological partner of PCTAIRE-2; with p11, a small dimeric protein with similarity to S100; and with 14-3-3 proteins, mediators of phosphorylation-dependent interactions in many different proteins. PCTAIRE-1 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270854 [Multi-domain]  Cd Length: 297  Bit Score: 76.97  E-value: 8.81e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQ--NVqFSEDTVRLYICEMALALDYLRSQHIIHRDV 100
Cdd:cd07873   49 REVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYL-DKDLKQYLDDcgNS-INMHNVKLFLFQLLRGLAYCHRRKVLHRDL 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 101 KPDNILLDEQGHAHLTDFNIA------TIIKDGERATALagtkpYMAPEIFHsfvnGGTGYSFEVDWWSVGVMAYELLRG 174
Cdd:cd07873  127 KPQNLLINERGELKLADFGLAraksipTKTYSNEVVTLW-----YRPPDILL----GSTDYSTQIDMWGVGCIFYEMSTG 197
                        170       180       190
                 ....*....|....*....|....*....|
gi 247269852 175 wRPYdIHSSNAVESLVQLFSTVSVQYVPTW 204
Cdd:cd07873  198 -RPL-FPGSTVEEQLHFIFRILGTPTEETW 225
STKc_MAPKAPK3 cd14172
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
49-230 1.02e-15

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 3 (MAPKAP3 or MK3) contains an N-terminal proline-rich region that can bind to SH3 domains, a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK3 is a bonafide substrate for the MAPK p38. It is closely related to MK2 and thus far, MK2/3 show indistinguishable substrate specificity. They are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. MK3 activity is only significant when MK2 is absent. The MK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271074 [Multi-domain]  Cd Length: 267  Bit Score: 76.18  E-value: 1.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  49 MFMVVDLLLGGDLRYHLQQ--NVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILL---DEQGHAHLTDFNIAti 123
Cdd:cd14172   76 LLIIMECMEGGELFSRIQErgDQAFTEREASEIMRDIGTAIQYLHSMNIAHRDVKPENLLYtskEKDAVLKLTDFGFA-- 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 124 iKDGERATALAG---TKPYMAPEIFhsfvnGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSvQY 200
Cdd:cd14172  154 -KETTVQNALQTpcyTPYYVAPEVL-----GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRMG-QY 226
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 247269852 201 ---VPTW---SKEMVALLRKLLTVNPEHRFSSLQDM 230
Cdd:cd14172  227 gfpNPEWaevSEEAKQLIRHLLKTDPTERMTITQFM 262
PKc_MKK5 cd06619
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
19-178 1.68e-15

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK5 (also called MEK5) is a dual-specificity PK that phosphorylates its downstream target, extracellular signal-regulated kinase 5 (ERK5), on specific threonine and tyrosine residues. MKK5 is activated by MEKK2 and MEKK3 in response to mitogenic and stress stimuli. The ERK5 cascade promotes cell proliferation, differentiation, neuronal survival, and neuroprotection. This cascade plays an essential role in heart development. Mice deficient in either ERK5 or MKK5 die around embryonic day 10 due to cardiovascular defects including underdevelopment of the myocardium. In addition, MKK5 is associated with metastasis and unfavorable prognosis in prostate cancer. The MKK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132950 [Multi-domain]  Cd Length: 279  Bit Score: 75.69  E-value: 1.68e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  19 RNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQqnvqFSEDTVRLYICEMALALDYLRSQHIIHR 98
Cdd:cd06619   44 KQIMSELEILYKCDSPYIIGFYGAFFVENRISICTEFMDGGSLDVYRK----IPEHVLGRIAVAVVKGLTYLWSLKILHR 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  99 DVKPDNILLDEQGHAHLTDFNIATIIKDgERATALAGTKPYMAPEIFhsfvnGGTGYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd06619  120 DVKPSNMLVNTRGQVKLCDFGVSTQLVN-SIAKTYVGTNAYMAPERI-----SGEQYGIHSDVWSLGISFMELALGRFPY 193
PTZ00024 PTZ00024
cyclin-dependent protein kinase; Provisional
21-174 1.85e-15

cyclin-dependent protein kinase; Provisional


Pssm-ID: 240233 [Multi-domain]  Cd Length: 335  Bit Score: 76.34  E-value: 1.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  21 VFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDV 100
Cdd:PTZ00024  67 TLRELKIMNEIKHENIMGLVDVYVEGDFINLVMDIM-ASDLKKVVDRKIRLTESQVKCILLQILNGLNVLHKWYFMHRDL 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 101 KPDNILLDEQGHAHLTDFNIAT---------------IIKDGERATALAGTKPYMAPEIFHsfvnGGTGYSFEVDWWSVG 165
Cdd:PTZ00024 146 SPANIFINSKGICKIADFGLARrygyppysdtlskdeTMQRREEMTSKVVTLWYRAPELLM----GAEKYHFAVDMWSVG 221

                 ....*....
gi 247269852 166 VMAYELLRG 174
Cdd:PTZ00024 222 CIFAELLTG 230
STKc_MEKK3 cd06651
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular ...
17-178 2.02e-15

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK3 is a MAPK kinase kinase (MAPKKK or MKKK), that phosphorylates and activates the MAPK kinase MEK5 (or MKK5), which in turn phosphorylates and activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. In addition, MEKK3 is involved in interleukin-1 receptor and Toll-like receptor 4 signaling. It is also a specific regulator of the proinflammatory cytokines IL-6 and GM-CSF in some immune cells. MEKK3 also regulates calcineurin, which plays a critical role in T cell activation, apoptosis, skeletal myocyte differentiation, and cardiac hypertrophy. The MEKK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270817 [Multi-domain]  Cd Length: 271  Bit Score: 75.50  E-value: 2.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  17 EVRNVFRELEILQEIEHVFLVNLWYSFQD--EEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQH 94
Cdd:cd06651   52 EVSALECEIQLLKNLQHERIVQYYGCLRDraEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNM 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  95 IIHRDVKPDNILLDEQGHAHLTDFN----IATIIKDGERATALAGTKPYMAPEIFhsfvnGGTGYSFEVDWWSVGVMAYE 170
Cdd:cd06651  132 IVHRDIKGANILRDSAGNVKLGDFGaskrLQTICMSGTGIRSVTGTPYWMSPEVI-----SGEGYGRKADVWSLGCTVVE 206

                 ....*...
gi 247269852 171 LLRGWRPY 178
Cdd:cd06651  207 MLTEKPPW 214
STKc_MLCK2 cd14190
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 2; STKs catalyze ...
3-231 2.09e-15

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK2 (or MYLK2) phosphorylates myosin regulatory light chain and controls the contraction of skeletal muscles. MLCK2 contains a single kinase domain near the C-terminus followed by a regulatory segment containing an autoinhibitory Ca2+/calmodulin binding site. The MLCK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271092 [Multi-domain]  Cd Length: 261  Bit Score: 75.34  E-value: 2.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNvfrELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL-QQNVQFSEDTVRLYIC 81
Cdd:cd14190   33 AAKVINKQNSKDKEMVLL---EIQVMNQLNHRNLIQLYEAIETPNEIVLFMEYVEGGELFERIvDEDYHLTEVDAMVFVR 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILL-DEQGH-AHLTDFNIATIIKDGERATALAGTKPYMAPEIF-HSFVnggtgySFE 158
Cdd:cd14190  110 QICEGIQFMHQMRVLHLDLKPENILCvNRTGHqVKIIDFGLARRYNPREKLKVNFGTPEFLSPEVVnYDQV------SFP 183
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 159 VDWWSVGVMAYELLRGWRPY----DIHSSNAVESLVQLFSTVSVQYVPTWSKEMVAllrKLLTVNPEHRFSSLQDMQ 231
Cdd:cd14190  184 TDMWSMGVITYMLLSGLSPFlgddDTETLNNVLMGNWYFDEETFEHVSDEAKDFVS---NLIIKERSARMSATQCLK 257
STKc_A-Raf cd14150
Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) ...
24-178 2.70e-15

Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. A-Raf cooperates with C-Raf in regulating ERK transient phosphorylation that is associated with cyclin D expression and cell cycle progression. Mice deficient in A-Raf are born alive but show neurological and intestinal defects. A-Raf demonstrates low kinase activity to MEK, compared with B- and C-Raf, and may also have alternative functions other than in the ERK signaling cascade. It regulates the M2 type pyruvate kinase, a key glycolytic enzyme. It also plays a role in endocytic membrane trafficking. A-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. It functions in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The A-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271052 [Multi-domain]  Cd Length: 265  Bit Score: 75.05  E-value: 2.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  24 ELEILQEIEHVFLVnLWYSFQDEEDMFMVVDLLLGGDLRYHLQ-QNVQFseDTVRLYIC--EMALALDYLRSQHIIHRDV 100
Cdd:cd14150   46 EMQVLRKTRHVNIL-LFMGFMTRPNFAIITQWCEGSSLYRHLHvTETRF--DTMQLIDVarQTAQGMDYLHAKNIIHRDL 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 101 KPDNILLDEQGHAHLTDFNIATIIKDGERATAL---AGTKPYMAPEIFHsfVNGGTGYSFEVDWWSVGVMAYELLRGWRP 177
Cdd:cd14150  123 KSNNIFLHEGLTVKIGDFGLATVKTRWSGSQQVeqpSGSILWMAPEVIR--MQDTNPYSFQSDVYAYGVVLYELMSGTLP 200

                 .
gi 247269852 178 Y 178
Cdd:cd14150  201 Y 201
STKc_PCTAIRE3 cd07871
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase; STKs catalyze the transfer ...
23-239 2.83e-15

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-3 shows a restricted pattern of expression and is present in brain, kidney, and intestine. It is elevated in Alzheimer's disease (AD) and has been shown to associate with paired helical filaments (PHFs) and stimulate Tau phosphorylation. As AD progresses, phosphorylated Tau aggregates and forms PHFs, which leads to the formation of neurofibrillary tangles. In human glioma cells, PCTAIRE-3 induces cell cycle arrest and cell death. PCTAIRE-3 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270853 [Multi-domain]  Cd Length: 288  Bit Score: 75.43  E-value: 2.83e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQ--NVqFSEDTVRLYICEMALALDYLRSQHIIHRDV 100
Cdd:cd07871   52 REVSLLKNLKHANIVTLHDIIHTERCLTLVFEYL-DSDLKQYLDNcgNL-MSMHNVKIFMFQLLRGLSYCHKRKILHRDL 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 101 KPDNILLDEQGHAHLTDFNIAtiikdgeRATALAgTKP---------YMAPEIFHsfvnGGTGYSFEVDWWSVGVMAYEL 171
Cdd:cd07871  130 KPQNLLINEKGELKLADFGLA-------RAKSVP-TKTysnevvtlwYRPPDVLL----GSTEYSTPIDMWGVGCILYEM 197
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 172 LRGwRPYdIHSSNAVESLVQLFSTVSVQYVPTWSKemvallrklLTVNPEHRFSSLQDMQTAPSLAHV 239
Cdd:cd07871  198 ATG-RPM-FPGSTVKEELHLIFRLLGTPTEETWPG---------VTSNEEFRSYLFPQYRAQPLINHA 254
STKc_Kalirin_C cd14115
C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide ...
3-178 3.21e-15

C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Kalirin, also called Duo or Duet, is a large multidomain protein containing a series of spectrin-like repeats, two each of RhoGEF and SH3 domains, an immunoglobulin-like (Ig) domain and a C-terminal kinase. As a GEF, it activates Rac1, RhoA, and RhoG. It is highly expressed in neurons and is required for spine formation. The kalirin gene produces at least 10 isoforms from alternative promoter use and splicing. Of the major isoforms (Kalirin-7, -9, and -12), only kalirin-12 contains the C-terminal kinase domain. Kalirin-12 is highly expressed during embryonic development and it plays an important role in axon outgrowth. The Kalirin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271017 [Multi-domain]  Cd Length: 248  Bit Score: 74.61  E-value: 3.21e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQqcIERDEvrNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICE 82
Cdd:cd14115   22 AVKFVSKK--MKKKE--QAAHEAALLQHLQHPQYITLHDTYESPTSYILVLELMDDGRLLDYLMNHDELMEEKVAFYIRD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQHIIHRDVKPDNILLDEQ---GHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFEV 159
Cdd:cd14115   98 IMEALQYLHNCRVAHLDIKPENLLIDLRipvPRVKLIDLEDAVQISGHRHVHHLLGNPEFAAPEVIQ-----GTPVSLAT 172
                        170
                 ....*....|....*....
gi 247269852 160 DWWSVGVMAYELLRGWRPY 178
Cdd:cd14115  173 DIWSIGVLTYVMLSGVSPF 191
STKc_TAK1 cd14058
Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated ...
13-179 3.35e-15

Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAK1 is also known as mitogen-activated protein kinase kinase kinase 7 (MAPKKK7 or MAP3K7), TAK, or MEKK7. As a MAPKKK, it is an important mediator of cellular responses to extracellular signals. It regulates both the c-Jun N-terminal kinase and p38 MAPK cascades by activating the MAPK kinases, MKK4 and MKK3/6. In addition, TAK1 plays diverse roles in immunity and development, in different biological contexts, through many signaling pathways including TGFbeta/BMP, Wnt/Fz, and NF-kB. It is also implicated in the activation of the tumor suppressor kinase, LKB1. The TAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270960 [Multi-domain]  Cd Length: 253  Bit Score: 74.40  E-value: 3.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  13 IERDEVRNVF-RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLryhlqQNVQFSEDTVRLYICEMAL------ 85
Cdd:cd14058   24 IESESEKKAFeVEVRQLSRVDHPNIIKLYGACSNQKPVCLVMEYAEGGSL-----YNVLHGKEPKPIYTAAHAMswalqc 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  86 --ALDYLRS---QHIIHRDVKPDNILLDEQGHA-HLTDFNIATIIKDgeRATALAGTKPYMAPEIFHsfvngGTGYSFEV 159
Cdd:cd14058   99 akGVAYLHSmkpKALIHRDLKPPNLLLTNGGTVlKICDFGTACDIST--HMTNNKGSAAWMAPEVFE-----GSKYSEKC 171
                        170       180
                 ....*....|....*....|
gi 247269852 160 DWWSVGVMAYELLRGWRPYD 179
Cdd:cd14058  172 DVFSWGIILWEVITRRKPFD 191
STKc_EIF2AK3_PERK cd14048
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
15-172 3.56e-15

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PERK (or EIF2AK3) is a type-I ER transmembrane protein containing a luminal domain bound with the chaperone BiP under unstressed conditions and a cytoplasmic catalytic kinase domain. In response to the accumulation of misfolded or unfolded proteins in the ER, PERK is activated through the release of BiP, allowing it to dimerize and autophosphorylate. It functions as the central regulator of translational control during the Unfolded Protein Response (UPR) pathway. In addition to the eIF-2 alpha subunit, PERK also phosphorylates Nrf2, a leucine zipper transcription factor which regulates cellular redox status and promotes cell survival during the UPR. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The PERK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270950 [Multi-domain]  Cd Length: 281  Bit Score: 74.91  E-value: 3.56e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  15 RDEVRN-VFRELEILQEIEHVFLVNLWYS--------FQDEED---MFMVVDLLLGGDLRYHLQQNVQFSE---DTVRLY 79
Cdd:cd14048   44 NELAREkVLREVRALAKLDHPGIVRYFNAwlerppegWQEKMDevyLYIQMQLCRKENLKDWMNRRCTMESrelFVCLNI 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE-------------RATALAGTKPYMAPEIFH 146
Cdd:cd14048  124 FKQIASAVEYLHSKGLIHRDLKPSNVFFSLDDVVKVGDFGLVTAMDQGEpeqtvltpmpayaKHTGQVGTRLYMSPEQIH 203
                        170       180
                 ....*....|....*....|....*.
gi 247269852 147 sfvngGTGYSFEVDWWSVGVMAYELL 172
Cdd:cd14048  204 -----GNQYSEKVDIFALGLILFELI 224
STKc_Titin cd14104
Catalytic domain of the Giant Serine/Threonine Kinase Titin; STKs catalyze the transfer of the ...
21-231 3.66e-15

Catalytic domain of the Giant Serine/Threonine Kinase Titin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Titin, also called connectin, is a muscle-specific elastic protein and is the largest known protein to date. It contains multiple immunoglobulin (Ig)-like and fibronectin type III (FN3) domains, and a single kinase domain near the C-terminus. It spans half of the sarcomere, the repeating contractile unit of striated muscle, and performs mechanical and catalytic functions. Titin contributes to the passive force generated when muscle is stretched during relaxation. Its kinase domain phosphorylates and regulates the muscle protein telethonin, which is required for sarcomere formation in differentiating myocytes. In addition, titin binds many sarcomere proteins and acts as a molecular scaffold for filament formation during myofibrillogenesis. The Titin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271006 [Multi-domain]  Cd Length: 277  Bit Score: 74.90  E-value: 3.66e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  21 VFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL-QQNVQFSEDTVRLYICEMALALDYLRSQHIIHRD 99
Cdd:cd14104   43 VKKEISILNIARHRNILRLHESFESHEELVMIFEFISGVDIFERItTARFELNEREIVSYVRQVCEALEFLHSKNIGHFD 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 100 VKPDNILLDEQ--GHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSFVnggtgYSFEVDWWSVGVMAYELLRGWRP 177
Cdd:cd14104  123 IRPENIIYCTRrgSYIKIIEFGQSRQLKPGDKFRLQYTSAEFYAPEVHQHES-----VSTATDMWSLGCLVYVLLSGINP 197
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 247269852 178 YDIHS-SNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd14104  198 FEAETnQQTIENIRNAEYAFDDEAFKNISIEALDFVDRLLVKERKSRMTAQEALN 252
STKc_MAPKAPK cd14089
Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated ...
42-232 3.80e-15

Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPK-activated protein kinases MK2, MK3, MK5 (also called PRAK for p38-regulated/activated protein kinase), and related proteins. These proteins contain a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. In addition, MK2 and MK3 contain an N-terminal proline-rich region that can bind to SH3 domains. MK2 and MK3 are bonafide substrates for the MAPK p38, while MK5 plays a functional role in the p38 MAPK pathway although their direct interaction has been difficult to detect. MK2 and MK3 are closely related and show, thus far, indistinguishable substrate specificity, while MK5 shows a distinct spectrum of substrates. MK2 and MK3 are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. MK5 is a ubiquitous protein that is implicated in neuronal morphogenesis, cell migration, and tumor angiogenesis. It interacts with PKA, which induces cytoplasmic translocation of MK5. Its substrates includes p53, ERK3/4, Hsp27, and cytosolic phospholipase A2 (cPLA2). The MAPKAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270991 [Multi-domain]  Cd Length: 263  Bit Score: 74.63  E-value: 3.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  42 SFQDEEDMFMVVDLLLGGDLRYHLQQNVQ--FSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILL---DEQGHAHLT 116
Cdd:cd14089   66 TYQGRKCLLVVMECMEGGELFSRIQERADsaFTEREAAEIMRQIGSAVAHLHSMNIAHRDLKPENLLYsskGPNAILKLT 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 117 DFNIAtiiKDGERATALAG---TKPYMAPEIFhsfvnGGTGYSFEVDWWSVGVMAYELLRGWRP-YDIHS---SNAVESL 189
Cdd:cd14089  146 DFGFA---KETTTKKSLQTpcyTPYYVAPEVL-----GPEKYDKSCDMWSLGVIMYILLCGYPPfYSNHGlaiSPGMKKR 217
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 247269852 190 VQlfstvSVQYV---PTW---SKEMVALLRKLLTVNPEHRFSSLQDMQT 232
Cdd:cd14089  218 IR-----NGQYEfpnPEWsnvSEEAKDLIRGLLKTDPSERLTIEEVMNH 261
STKc_MAP4K3 cd06645
Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase ...
21-231 4.10e-15

Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP4K3 plays a role in the nutrient-responsive pathway of mTOR (mammalian target of rapamycin) signaling. MAP4K3 is required in the activation of S6 kinase by amino acids and for the phosphorylation of the mTOR-regulated inhibitor of eukaryotic initiation factor 4E. mTOR regulates ribosome biogenesis and protein translation, and is frequently deregulated in cancer. MAP4Ks are involved in MAPK signaling pathways by activating a MAPK kinase kinase. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. The MAP4K3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270812 [Multi-domain]  Cd Length: 272  Bit Score: 74.70  E-value: 4.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  21 VFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLR--YHLQQnvQFSEDTVRlYICEMAL-ALDYLRSQHIIH 97
Cdd:cd06645   55 VQQEIIMMKDCKHSNIVAYFGSYLRRDKLWICMEFCGGGSLQdiYHVTG--PLSESQIA-YVSRETLqGLYYLHSKGKMH 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  98 RDVKPDNILLDEQGHAHLTDFNI-ATIIKDGERATALAGTKPYMAPEIfhSFVNGGTGYSFEVDWWSVGVMAYELLRGWR 176
Cdd:cd06645  132 RDIKGANILLTDNGHVKLADFGVsAQITATIAKRKSFIGTPYWMAPEV--AAVERKGGYNQLCDIWAVGITAIELAELQP 209
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 177 P-YDIHSSNAVESLVQL-FSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd06645  210 PmFDLHPMRALFLMTKSnFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQ 266
STKc_SPEG_rpt1 cd14108
Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle ...
23-178 5.82e-15

Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Striated muscle preferentially expressed gene (SPEG) generates 4 different isoforms through alternative promoter use and splicing in a tissue-specific manner: SPEGalpha and SPEGbeta are expressed in cardiac and skeletal striated muscle; Aortic Preferentially Expressed Protein-1 (APEG-1) is expressed in vascular smooth muscle; and Brain preferentially expressed gene (BPEG) is found in the brain and aorta. SPEG proteins have mutliple immunoglobulin (Ig), 2 fibronectin type III (FN3), and two kinase domains. They are necessary for cardiac development and survival. The SPEG subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271010 [Multi-domain]  Cd Length: 255  Bit Score: 73.78  E-value: 5.82e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKP 102
Cdd:cd14108   47 RELALLAELDHKSIVRFHDAFEKRRVVIIVTELC-HEELLERITKRPTVCESEVRSYMRQLLEGIEYLHQNDVLHLDLKP 125
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 247269852 103 DNILLDEQG--HAHLTDFNIATIIKDGERATALAGTKPYMAPEIFH-SFVNGGTgysfevDWWSVGVMAYELLRGWRPY 178
Cdd:cd14108  126 ENLLMADQKtdQVRICDFGNAQELTPNEPQYCKYGTPEFVAPEIVNqSPVSKVT------DIWPVGVIAYLCLTGISPF 198
STKc_obscurin_rpt1 cd14107
Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs ...
22-228 6.04e-15

Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Obscurin, approximately 800 kDa in size, is one of three giant proteins expressed in vetebrate striated muscle, together with titin and nebulin. It is a multidomain protein composed of tandem adhesion and signaling domains, including 49 immunoglobulin (Ig) and 2 fibronectin type III (FN3) domains at the N-terminus followed by a more complex region containing more Ig domains, a conserved SH3 domain near a RhoGEF and PH domains, non-modular regions, as well as IQ and phosphorylation motifs. The obscurin gene also encode two kinase domains, which are not expressed as part of the 800 kDa protein, but as a smaller, alternatively spliced product present mainly in the heart muscle, also called obscurin-MLCK. Obscurin is localized at the peripheries of Z-disks and M-lines, where it is able to communicate with the surrounding myoplasm. It interacts with diverse proteins including sAnk1, myosin, titin, and MyBP-C. It may act as a scaffold for the assembly of elements of the contractile apparatus. The obscurin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271009 [Multi-domain]  Cd Length: 257  Bit Score: 73.77  E-value: 6.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  22 FRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVK 101
Cdd:cd14107   46 FQERDILARLSHRRLTCLLDQFETRKTLILILELCSSEELLDRLFLKGVVTEAEVKLYIQQVLEGIGYLHGMNILHLDIK 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 102 PDNILL--DEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFH-SFVNGGTgysfevDWWSVGVMAYELLRGWRPY 178
Cdd:cd14107  126 PDNILMvsPTREDIKICDFGFAQEITPSEHQFSKYGSPEFVAPEIVHqEPVSAAT------DIWALGVIAYLSLTCHSPF 199
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 179 DIHSSNAVESLVQlfstvsvQYVPTWSKEMVA--------LLRKLLTVNPEHRFSSLQ 228
Cdd:cd14107  200 AGENDRATLLNVA-------EGVVSWDTPEIThlsedakdFIKRVLQPDPEKRPSASE 250
STKc_CDK6 cd07862
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6; STKs ...
20-220 7.95e-15

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK6 is regulated by D-type cyclins and INK4 inhibitors. It is active towards the retinoblastoma (pRb) protein, implicating it to function in regulating the early G1 phase of the cell cycle. It is expressed ubiquitously and is localized in the cytoplasm. It is also present in the ruffling edge of spreading fibroblasts and may play a role in cell spreading. It binds to the p21 inhibitor without any effect on its own activity and it is overexpressed in squamous cell carcinomas and neuroblastomas. CDK6 has also been shown to inhibit cell differentiation in many cell types. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270846 [Multi-domain]  Cd Length: 290  Bit Score: 73.91  E-value: 7.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  20 NVFRELEILQEIE---HVFLVNLW----YSFQDEEDMFMVVDLLLGGDLRYHLQQNVQ--FSEDTVRLYICEMALALDYL 90
Cdd:cd07862   47 STIREVAVLRHLEtfeHPNVVRLFdvctVSRTDRETKLTLVFEHVDQDLTTYLDKVPEpgVPTETIKDMMFQLLRGLDFL 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  91 RSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYE 170
Cdd:cd07862  127 HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQ-----SSYATPVDLWSVGCIFAE 201
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 247269852 171 LLRGwRPYdIHSSNAVESLVQLFSTVSVQYVPTWSKEmVALLRKLLTVNP 220
Cdd:cd07862  202 MFRR-KPL-FRGSSDVDQLGKILDVIGLPGEEDWPRD-VALPRQAFHSKS 248
STKc_MAP3K12_13 cd14059
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase ...
82-183 8.19e-15

Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP3K12 is also called MAPK upstream kinase (MUK), dual leucine zipper-bearing kinase (DLK) or leucine-zipper protein kinase (ZPK). It is involved in the c-Jun N-terminal kinase (JNK) pathway that directly regulates axonal regulation through the phosphorylation of microtubule-associated protein 1B (MAP1B). It also regulates the differentiation of many cell types including adipocytes and may play a role in adipogenesis. MAP3K13, also called leucine zipper-bearing kinase (LZK), directly phosphorylates and activates MKK7, which in turn activates the JNK pathway. It also activates NF-kB through IKK activation and this activity is enhanced by antioxidant protein-1 (AOP-1). MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAP2Ks (MAPKKs or MKKs), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The MAP3K12/13 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270961 [Multi-domain]  Cd Length: 237  Bit Score: 73.30  E-value: 8.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEVDW 161
Cdd:cd14059   89 QIASGMNYLHLHKIIHRDLKSPNVLVTYNDVLKISDFGTSKELSEKSTKMSFAGTVAWMAPEVIRN-----EPCSEKVDI 163
                         90       100
                 ....*....|....*....|...
gi 247269852 162 WSVGVMAYELLRGWRPY-DIHSS 183
Cdd:cd14059  164 WSFGVVLWELLTGEIPYkDVDSS 186
STKc_PIM cd14005
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
3-234 9.39e-15

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are two PIM1 and three PIM2 isoforms as a result of alternative translation initiation sites, while there is only one PIM3 protein. Compound knockout mice deficient of all three PIM kinases that survive the perinatal period show a profound reduction in body size, indicating that PIMs are important for body growth. The PIM subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270907 [Multi-domain]  Cd Length: 255  Bit Score: 73.42  E-value: 9.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNVFReleILQEIEHVFLVNL-----------WYsfqDEEDMFMVV--------DLL----LGG 59
Cdd:cd14005   29 AVKFVPKSRVTEWAMINGPVP---VPLEIALLLKASKpgvpgvirlldWY---ERPDGFLLImerpepcqDLFdfitERG 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  60 DLryhlqqnvqfSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLD-EQGHAHLTDFNIATIIKDGERaTALAGTKP 138
Cdd:cd14005  103 AL----------SENLARIIFRQVVEAVRHCHQRGVLHRDIKDENLLINlRTGEVKLIDFGCGALLKDSVY-TDFDGTRV 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 139 YMAPE-IFHSFVNGGTGYSfevdwWSVGVMAYELLRGWRPYdiHSSnaveslvQLFSTVSVQYVPTWSKEMVALLRKLLT 217
Cdd:cd14005  172 YSPPEwIRHGRYHGRPATV-----WSLGILLYDMLCGDIPF--END-------EQILRGNVLFRPRLSKECCDLISRCLQ 237
                        250
                 ....*....|....*..
gi 247269852 218 VNPEHRfSSLQDMQTAP 234
Cdd:cd14005  238 FDPSKR-PSLEQILSHP 253
STKc_TSSK3-like cd14163
Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins; STKs ...
3-241 9.81e-15

Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK3 has been reported to be expressed in the interstitial Leydig cells of adult testis. Its mRNA levels is low at birth, increases at puberty, and remains high throughout adulthood. The TSSK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271065 [Multi-domain]  Cd Length: 257  Bit Score: 73.10  E-value: 9.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEE-DMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC 81
Cdd:cd14163   29 AIKIIDKSGGPEEFIQRFLPRELQIVERLDHKNIIHVYEMLESADgKIYLVMELAEDGDVFDCVLHGGPLPEHRAKALFR 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLdeQG-HAHLTDFNIATIIKDGER--ATALAGTKPYMAPEIFHsfvnGGTGYSFE 158
Cdd:cd14163  109 QLVEAIRYCHGCGVAHRDLKCENALL--QGfTLKLTDFGFAKQLPKGGRelSQTFCGSTAYAAPEVLQ----GVPHDSRK 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGWRPYDihSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTvnpehrfsslQDMQTAPSLAH 238
Cdd:cd14163  183 GDIWSMGVVLYVMLCAQLPFD--DTDIPKMLCQQQKGVSLPGHLGVSRTCQDLLKRLLE----------PDMVLRPSIEE 250

                 ...
gi 247269852 239 VLW 241
Cdd:cd14163  251 VSW 253
STKc_myosinIIIA_N cd06638
N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIA myosin; STKs catalyze ...
47-231 1.02e-14

N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIA myosin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class IIIA myosin is highly expressed in retina and in inner ear hair cells. It is localized to the distal ends of actin-bundled structures. Mutations in human myosin IIIA are responsible for progressive nonsyndromic hearing loss. Human myosin IIIA possesses ATPase and kinase activities, and the ability to move actin filaments in a motility assay. It may function as a cellular transporter capable of moving along actin bundles in sensory cells. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain. Class III myosins may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. In photoreceptor cells, they may also function as cargo carriers during light-dependent translocation of proteins such as transducin and arrestin. The class III myosin subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132969 [Multi-domain]  Cd Length: 286  Bit Score: 73.89  E-value: 1.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  47 EDMFMVVDLLLGG---DL-RYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNI-A 121
Cdd:cd06638   93 DQLWLVLELCNGGsvtDLvKGFLKRGERMEEPIIAYILHEALMGLQHLHVNKTIHRDVKGNNILLTTEGGVKLVDFGVsA 172
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 122 TIIKDGERATALAGTKPYMAPEIFHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPY-DIHSSNAVESLVQlFSTVSVQY 200
Cdd:cd06638  173 QLTSTRLRRNTSVGTPFWMAPEVIACEQQLDSTYDARCDVWSLGITAIELGDGDPPLaDLHPMRALFKIPR-NPPPTLHQ 251
                        170       180       190
                 ....*....|....*....|....*....|.
gi 247269852 201 VPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd06638  252 PELWSNEFNDFIRKCLTKDYEKRPTVSDLLQ 282
STKc_MOK cd07831
Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase; STKs ...
2-231 1.17e-14

Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MOK, also called Renal tumor antigen 1 (RAGE-1), is widely expressed and is enriched in testis, kidney, lung, and brain. It is expressed in approximately 50% of renal cell carcinomas (RCC) and is a potential target for immunotherapy. MOK is stabilized by its association with the HSP90 molecular chaperone. It is induced by the transcription factor Cdx2 and may be involved in regulating intestinal epithelial development and differentiation. The MOK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270825 [Multi-domain]  Cd Length: 282  Bit Score: 73.46  E-value: 1.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMnKQQCIERDEVRNvFRELE----------ILQEIEHVFlvnlwysfqDE---------EDMFMVVDLLLGGDLR 62
Cdd:cd07831   27 YAIKCM-KKHFKSLEQVNN-LREIQalrrlsphpnILRLIEVLF---------DRktgrlalvfELMDMNLYELIKGRKR 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  63 YhlqqnvqFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDeQGHAHLTDFNIATIIKDGERATALAGTKPYMAP 142
Cdd:cd07831   96 P-------LPEKRVKNYMYQLLKSLDHMHRNGIFHRDIKPENILIK-DDILKLADFGSCRGIYSKPPYTEYISTRWYRAP 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 143 EIFHSfvnggTG-YSFEVDWWSVGVMAYELLR------GWRPYD----IHS-----SNAVESLVQLFSTVSVQY------ 200
Cdd:cd07831  168 ECLLT-----DGyYGPKMDIWAVGCVFFEILSlfplfpGTNELDqiakIHDvlgtpDAEVLKKFRKSRHMNYNFpskkgt 242
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 247269852 201 -----VPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd07831  243 glrklLPNASAEGLDLLKKLLAYDPDERITAKQALR 278
STKc_CDK2_3 cd07860
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3; ...
23-226 1.20e-14

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. The CDK2/cyclin A complex plays a role in regulating DNA replication. CDK2, together with CDK4, also regulates embryonic cell proliferation. Despite these important roles, mice deleted for the cdk2 gene are viable and normal except for being sterile. This may be due to compensation provided by CDK1 (also called Cdc2), which can also bind cyclin E and drive the G1 to S phase transition. CDK3 is regulated by cyclin C and it phosphorylates pRB specifically during the G0/G1 transition. This phosphorylation is required for cells to exit G0 efficiently and enter the G1 phase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270844 [Multi-domain]  Cd Length: 284  Bit Score: 73.31  E-value: 1.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQ--QNVQFSEDTVRLYICEMALALDYLRSQHIIHRDV 100
Cdd:cd07860   48 REISLLKELNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDasALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDL 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 101 KPDNILLDEQGHAHLTDFNIATIIKDGERA-TALAGTKPYMAPEIFHsfvnGGTGYSFEVDWWSVGVMAYELL--RGWRP 177
Cdd:cd07860  127 KPQNLLINTEGAIKLADFGLARAFGVPVRTyTHEVVTLWYRAPEILL----GCKYYSTAVDIWSLGCIFAEMVtrRALFP 202
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 178 YDihssNAVESLVQLFSTVSV----------------------------QYVPTWSKEMVALLRKLLTVNPEHRFSS 226
Cdd:cd07860  203 GD----SEIDQLFRIFRTLGTpdevvwpgvtsmpdykpsfpkwarqdfsKVVPPLDEDGRDLLSQMLHYDPNKRISA 275
STKc_CDK1_euk cd07861
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher ...
23-226 1.23e-14

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression. CDK1/cyclin A2 has also been implicated as an important regulator of S phase events. The CDK1/cyclin B complex is critical for G2 to M phase transition. It induces mitosis by activating nuclear enzymes that regulate chromatin condensation, nuclear membrane degradation, mitosis-specific microtubule and cytoskeletal reorganization. CDK1 also associates with cyclin E and plays a role in the entry into S phase. CDK1 transcription is stable throughout the cell cycle but is modulated in some pathological conditions. It may play a role in regulating apoptosis under these conditions. In breast cancer cells, HER2 can mediate apoptosis by inactivating CDK1. Activation of CDK1 may contribute to HIV-1 induced apoptosis as well as neuronal apoptosis in neurodegenerative diseases. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270845 [Multi-domain]  Cd Length: 285  Bit Score: 73.22  E-value: 1.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQ---NVQFSEDTVRLYICEMALALDYLRSQHIIHRD 99
Cdd:cd07861   48 REISLLKELQHPNIVCLEDVLMQENRLYLVFEFL-SMDLKKYLDSlpkGKYMDAELVKSYLYQILQGILFCHSRRVLHRD 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 100 VKPDNILLDEQGHAHLTDFNIATIIKDGERA-TALAGTKPYMAPEIFHsfvnGGTGYSFEVDWWSVGVMAYELLRGwRPY 178
Cdd:cd07861  127 LKPQNLLIDNKGVIKLADFGLARAFGIPVRVyTHEVVTLWYRAPEVLL----GSPRYSTPVDIWSIGTIFAEMATK-KPL 201
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 179 dIHSSNAVESLVQLFSTV------------SVQ----YVPTWSKEMVA------------LLRKLLTVNPEHRFSS 226
Cdd:cd07861  202 -FHGDSEIDQLFRIFRILgtptediwpgvtSLPdyknTFPKWKKGSLRtavknldedgldLLEKMLIYDPAKRISA 276
STKc_p38delta cd07879
Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase ...
19-251 1.49e-14

Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase (also called MAPK13); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38delta/MAPK13 is found in skeletal muscle, heart, lung, testis, pancreas, and small intestine. It regulates microtubule function by phosphorylating Tau. It activates the c-jun promoter and plays a role in G2 cell cycle arrest. It also controls the degration of c-Myb, which is associated with myeloid leukemia and poor prognosis in colorectal cancer. p38delta is the main isoform involved in regulating the differentiation and apoptosis of keratinocytes. p38 kinases are MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38delta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143384 [Multi-domain]  Cd Length: 342  Bit Score: 73.78  E-value: 1.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  19 RNVFRELEILQEIEHVFLVNLW------YSFQDEEDMFMVVDLLlggdlRYHLQQ--NVQFSEDTVRLYICEMALALDYL 90
Cdd:cd07879   59 KRAYRELTLLKHMQHENVIGLLdvftsaVSGDEFQDFYLVMPYM-----QTDLQKimGHPLSEDKVQYLVYQMLCGLKYI 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  91 RSQHIIHRDVKPDNILLDEQGHAHLTDFNIATiIKDGErATALAGTKPYMAPEIFHSFVNggtgYSFEVDWWSVGVMAYE 170
Cdd:cd07879  134 HSAGIIHRDLKPGNLAVNEDCELKILDFGLAR-HADAE-MTGYVVTRWYRAPEVILNWMH----YNQTVDIWSVGCIMAE 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 171 LLRGWRPY----------------------------DIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEH 222
Cdd:cd07879  208 MLTGKTLFkgkdyldqltqilkvtgvpgpefvqkleDKAAKSYIKSLPKYPRKDFSTLFPKASPQAVDLLEKMLELDVDK 287
                        250       260
                 ....*....|....*....|....*....
gi 247269852 223 RFSSLQdmqtapSLAHVLWDDLSEKKVEP 251
Cdd:cd07879  288 RLTATE------ALEHPYFDSFRDADEET 310
PK_Unc-89_rpt1 cd14109
Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein ...
21-225 1.65e-14

Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. The nematode Unc-89 gene, through alternative promoter use and splicing, encodes at least six major isoforms (Unc-89A to Unc-89F) of giant muscle proteins that are homologs for the vetebrate obscurin. In flies, five isoforms of Unc-89 have been detected: four in the muscles of adult flies (two in the indirect flight muscle and two in other muscles) and another isoform in the larva. Unc-89 in nematodes is required for normal muscle cell architecture. In flies, it is necessary for the development of a symmetrical sarcomere in the flight muscles. Unc-89 proteins contain several adhesion and signaling domains including multiple copies of the immunoglobulin (Ig) domain, as well as fibronectin type III (FN3), SH3, RhoGEF, and PH domains. The nematode Unc-89 isoforms D, C, D, and F contain two kinase domain with B and F having two complete kinase domains while the first repeat of C and D are partial domains. Homology modeling suggests that the first kinase repeat of Unc-89 may be catalytically inactive, a pseudokinase, while the second kinase repeat may be active. The pseudokinase domain may function as a regulatory domain or a protein interaction domain. The Unc-89 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271011 [Multi-domain]  Cd Length: 255  Bit Score: 72.54  E-value: 1.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  21 VFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGG--DLRYHLQQNVQF-SEDTVRLYICEMALALDYLRSQHIIH 97
Cdd:cd14109   43 LMREVDIHNSLDHPNIVQMHDAYDDEKLAVTVIDNLASTieLVRDNLLPGKDYyTERQVAVFVRQLLLALKHMHDLGIAH 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  98 RDVKPDNILLDEQgHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSFvnggtGYSFEVDWWSVGVMAYELLRGWRP 177
Cdd:cd14109  123 LDLRPEDILLQDD-KLKLADFGQSRRLLRGKLTTLIYGSPEFVSPEIVNSY-----PVTLATDMWSVGVLTYVLLGGISP 196
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 247269852 178 YdiHSSNAVESLVQLFSTVSVQYVPTW---SKEMVALLRKLLTVNPEHRFS 225
Cdd:cd14109  197 F--LGDNDRETLTNVRSGKWSFDSSPLgniSDDARDFIKKLLVYIPESRLT 245
PTKc_Syk_like cd05060
Catalytic domain of Spleen Tyrosine Kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
3-230 1.66e-14

Catalytic domain of Spleen Tyrosine Kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Syk-like subfamily is composed of Syk, ZAP-70, Shark, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. They are involved in the signaling downstream of activated receptors (including B-cell, T-cell, and Fc receptors) that contain ITAMs (immunoreceptor tyr activation motifs), leading to processes such as cell proliferation, differentiation, survival, adhesion, migration, and phagocytosis. Syk is important in B-cell receptor signaling, while Zap-70 is primarily expressed in T-cells and NK cells, and is a crucial component in T-cell receptor signaling. Syk also plays a central role in Fc receptor-mediated phagocytosis in the adaptive immune system. Shark is exclusively expressed in ectodermally derived epithelia, and is localized preferentially to the apical surface of the epithelial cells, it may play a role in a signaling pathway for epithelial cell polarity. The Syk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270650 [Multi-domain]  Cd Length: 257  Bit Score: 72.77  E-value: 1.66e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMnKQQCIERDEvRNVFRELEILQEIEHVFLVNLwYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICE 82
Cdd:cd05060   27 AVKTL-KQEHEKAGK-KEFLREASVMAQLDHPCIVRL-IGVCKGEPLMLVMELAPLGPLLKYLKKRREIPVSDLKELAHQ 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE---RATAlAGTKP--YMAPEIFHSFVnggtgYSF 157
Cdd:cd05060  104 VAMGMAYLESKHFVHRDLAARNVLLVNRHQAKISDFGMSRALGAGSdyyRATT-AGRWPlkWYAPECINYGK-----FSS 177
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 158 EVDWWSVGVMAYELL-RGWRPYDIHSSNAVESLVQlfSTVSVQYVPTWSKEMVALLRKLLTVNPEHR--FSSLQDM 230
Cdd:cd05060  178 KSDVWSYGVTLWEAFsYGAKPYGEMKGPEVIAMLE--SGERLPRPEECPQEIYSIMLSCWKYRPEDRptFSELEST 251
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
44-230 1.68e-14

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 74.83  E-value: 1.68e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  44 QDEEDM--FMV---VDlllGGDLRYHLQQNVQFS-EDTVRLYIcEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTD 117
Cdd:NF033483  75 VGEDGGipYIVmeyVD---GRTLKDYIREHGPLSpEEAVEIMI-QILSALEHAHRNGIVHRDIKPQNILITKDGRVKVTD 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 118 FNIAtiikdgeRA---------TALAGTKPYMAPE-IFHSFVNggtgysFEVDWWSVGVMAYELLRGWRPYDIHSsnAVE 187
Cdd:NF033483 151 FGIA-------RAlssttmtqtNSVLGTVHYLSPEqARGGTVD------ARSDIYSLGIVLYEMLTGRPPFDGDS--PVS 215
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 247269852 188 SLVQLFS--TVSV-QYVPTWSKEMVALLRKLLTVNPEHRFSSLQDM 230
Cdd:NF033483 216 VAYKHVQedPPPPsELNPGIPQSLDAVVLKATAKDPDDRYQSAAEM 261
STKc_TNIK cd06637
Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase; STKs ...
79-231 2.04e-14

Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TNIK is an effector of Rap2, a small GTP-binding protein from the Ras family. TNIK specifically activates the c-Jun N-terminal kinase (JNK) pathway and plays a role in regulating the actin cytoskeleton. The TNIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270807 [Multi-domain]  Cd Length: 296  Bit Score: 72.83  E-value: 2.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YIC-EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNI-ATIIKDGERATALAGTKPYMAPEIFHSFVNGGTGYS 156
Cdd:cd06637  115 YICrEILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVsAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYD 194
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 157 FEVDWWSVGVMAYELLRGWRPY-DIHSSNAVESLVQlfSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd06637  195 FKSDLWSLGITAIEMAEGAPPLcDMHPMRALFLIPR--NPAPRLKSKKWSKKFQSFIESCLVKNHSQRPSTEQLMK 268
PLN00009 PLN00009
cyclin-dependent kinase A; Provisional
23-244 2.60e-14

cyclin-dependent kinase A; Provisional


Pssm-ID: 177649 [Multi-domain]  Cd Length: 294  Bit Score: 72.54  E-value: 2.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQNVQFSED--TVRLYICEMALALDYLRSQHIIHRDV 100
Cdd:PLN00009  50 REISLLKEMQHGNIVRLQDVVHSEKRLYLVFEYL-DLDLKKHMDSSPDFAKNprLIKTYLYQILRGIAYCHSHRVLHRDL 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 101 KPDNILLDEQGHA-HLTDFNIATIIKDGERA-TALAGTKPYMAPEIFHsfvnGGTGYSFEVDWWSVGVMAYELL--RGWR 176
Cdd:PLN00009 129 KPQNLLIDRRTNAlKLADFGLARAFGIPVRTfTHEVVTLWYRAPEILL----GSRHYSTPVDIWSVGCIFAEMVnqKPLF 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 177 PYDihssNAVESLVQLFSTVSVQY----------------------------VPTWSKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:PLN00009 205 PGD----SEIDELFKIFRILGTPNeetwpgvtslpdyksafpkwppkdlatvVPTLEPAGVDLLSKMLRLDPSKRITARA 280
                        250
                 ....*....|....*.
gi 247269852 229 dmqtapSLAHVLWDDL 244
Cdd:PLN00009 281 ------ALEHEYFKDL 290
STKc_CDK4 cd07863
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4; STKs ...
23-231 3.38e-14

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK4 partners with all three D-type cyclins (D1, D2, and D3) and is also regulated by INK4 inhibitors. It is active towards the retinoblastoma (pRb) protein and plays a role in regulating the early G1 phase of the cell cycle. It is expressed ubiquitously and is localized in the nucleus. CDK4 also shows kinase activity towards Smad3, a signal transducer of TGF-beta signaling which modulates transcription and plays a role in cell proliferation and apoptosis. CDK4 is inhibited by the p21 inhibitor and is specifically mutated in human melanoma. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143368 [Multi-domain]  Cd Length: 288  Bit Score: 72.30  E-value: 3.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEH------VFLVNLWYSFQ-DEEDMFMVVDLLLGGDLRYHLQQNVQ--FSEDTVRLYICEMALALDYLRSQ 93
Cdd:cd07863   48 REVALLKRLEAfdhpniVRLMDVCATSRtDRETKVTLVFEHVDQDLRTYLDKVPPpgLPAETIKDLMRQFLRGLDFLHAN 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  94 HIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELLR 173
Cdd:cd07863  128 CIVHRDLKPENILVTSGGQVKLADFGLARIYSCQMALTPVVVTLWYRAPEVLLQ-----STYATPVDMWSVGCIFAEMFR 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 174 GwRPYDIHSSNAvESLVQLFSTVSV--------------------------QYVPTWSKEMVALLRKLLTVNPEHRFSSL 227
Cdd:cd07863  203 R-KPLFCGNSEA-DQLGKIFDLIGLppeddwprdvtlprgafsprgprpvqSVVPEIEESGAQLLLEMLTFNPHKRISAF 280

                 ....
gi 247269852 228 QDMQ 231
Cdd:cd07863  281 RALQ 284
STKc_EIF2AK4_GCN2_rpt2 cd14046
Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation ...
19-233 3.61e-14

Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GCN2 (or EIF2AK4) is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. Its kinase domain is activated via conformational changes as a result of the binding of uncharged tRNA to the HisRS-like domain. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270948 [Multi-domain]  Cd Length: 278  Bit Score: 72.02  E-value: 3.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  19 RNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHR 98
Cdd:cd14046   49 SRILREVMLLSRLNHQHVVRYYQAWIERANLYIQMEYCEKSTLRDLIDSGLFQDTDRLWRLFRQILEGLAYIHSQGIIHR 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  99 DVKPDNILLDEQGHAHLTDFNIATIIK-------------------DGERATALAGTKPYMAPEifhsfVNGGTG--YSF 157
Cdd:cd14046  129 DLKPVNIFLDSNGNVKIGDFGLATSNKlnvelatqdinkstsaalgSSGDLTGNVGTALYVAPE-----VQSGTKstYNE 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 158 EVDWWSVGVMAYELlrgWRPYDIhSSNAVESLVQLFStVSVQYVPTWSK----EMVALLRKLLTVNPEHRFSSLQDMQTA 233
Cdd:cd14046  204 KVDMYSLGIIFFEM---CYPFST-GMERVQILTALRS-VSIEFPPDFDDnkhsKQAKLIRWLLNHDPAKRPSAQELLKSE 278
STKc_C-Raf cd14149
Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) ...
22-178 4.09e-14

Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. C-Raf, also known as Raf-1 or c-Raf-1, is ubiquitously expressed and was the first Raf identified. It was characterized as the acquired oncogene from an acutely transforming murine sarcoma virus (3611-MSV) and the transforming agent from the avian retrovirus MH2. C-Raf-deficient mice embryos die around midgestation with increased apoptosis of embryonic tissues, especially in the fetal liver. One of the main functions of C-Raf is restricting caspase activation to promote survival in response to specific stimuli such as Fas stimulation, macrophage apoptosis, and erythroid differentiation. C-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. It functions in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The C-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271051 [Multi-domain]  Cd Length: 283  Bit Score: 71.99  E-value: 4.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  22 FR-ELEILQEIEHVFLVnLWYSFQDEEDMFMVVDLLLGGDLRYHLQ-QNVQFSEDTVRLYICEMALALDYLRSQHIIHRD 99
Cdd:cd14149   55 FRnEVAVLRKTRHVNIL-LFMGYMTKDNLAIVTQWCEGSSLYKHLHvQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRD 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 100 VKPDNILLDEQGHAHLTDFNIATI---IKDGERATALAGTKPYMAPEIFHsfVNGGTGYSFEVDWWSVGVMAYELLRGWR 176
Cdd:cd14149  134 MKSNNIFLHEGLTVKIGDFGLATVksrWSGSQQVEQPTGSILWMAPEVIR--MQDNNPFSFQSDVYSYGIVLYELMTGEL 211

                 ..
gi 247269852 177 PY 178
Cdd:cd14149  212 PY 213
STKc_MAPKAPK2 cd14170
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
43-247 4.65e-14

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 2 (MAPKAP2 or MK2) contains an N-terminal proline-rich region that can bind to SH3 domains, a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK2 is a bonafide substrate for the MAPK p38. It is closely related to MK3 and thus far, MK2/3 show indistinguishable substrate specificity. They are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. The MK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271072 [Multi-domain]  Cd Length: 303  Bit Score: 71.99  E-value: 4.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  43 FQDEEDMFMVVDLLLGGDLRYHLQQ--NVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQ---GHAHLTD 117
Cdd:cd14170   68 YAGRKCLLIVMECLDGGELFSRIQDrgDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKrpnAILKLTD 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 118 FNIAtiiKDGERATALAG---TKPYMAPEIFhsfvnGGTGYSFEVDWWSVGVMAYELLRGWRP-YDIHSSNAVESLVQLF 193
Cdd:cd14170  148 FGFA---KETTSHNSLTTpcyTPYYVAPEVL-----GPEKYDKSCDMWSLGVIMYILLCGYPPfYSNHGLAISPGMKTRI 219
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 194 STVSVQYV-PTWSK---EMVALLRKLLTVNPEHRFS---------SLQDMQTAPSLAHV---------LWDDLSEK 247
Cdd:cd14170  220 RMGQYEFPnPEWSEvseEVKMLIRNLLKTEPTQRMTitefmnhpwIMQSTKVPQTPLHTsrvlkedkeRWEDVKEE 295
STKc_CDKL5 cd07848
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5; STKs ...
14-238 4.76e-14

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mutations in the gene encoding CDKL5, previously called STK9, are associated with early onset epilepsy and severe mental retardation [X-linked infantile spasm syndrome (ISSX) or West syndrome]. In addition, CDKL5 mutations also sometimes cause a phenotype similar to Rett syndrome (RTT), a progressive neurodevelopmental disorder. These pathogenic mutations are located in the N-terminal portion of the protein within the kinase domain. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270838 [Multi-domain]  Cd Length: 287  Bit Score: 71.57  E-value: 4.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  14 ERDEVR-NVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRS 92
Cdd:cd07848   39 ENEEVKeTTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVRSYIYQLIKAIHWCHK 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERA--TALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYE 170
Cdd:cd07848  119 NDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGSNAnyTEYVATRWYRSPELLL-----GAPYGKAVDMWSVGCILGE 193
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 171 LLRGWRPYDIHSsnaveSLVQLFsTVSVQYVPTWSKEMvallrKLLTVNPehRFSSLQdmqtAPSLAH 238
Cdd:cd07848  194 LSDGQPLFPGES-----EIDQLF-TIQKVLGPLPAEQM-----KLFYSNP--RFHGLR----FPAVNH 244
STKc_TAO1 cd06635
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1; STKs catalyze ...
4-192 6.24e-14

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO1 is sometimes referred to as prostate-derived sterile 20-like kinase 2 (PSK2). TAO1 activates the p38 MAPK through direct interaction with and activation of MEK3. TAO1 is highly expressed in the brain and may play a role in neuronal apoptosis. TAO1 interacts with the checkpoint proteins BubR1 and Mad2, and plays an important role in regulating mitotic progression, which is required for both chromosome congression and checkpoint-induced anaphase delay. TAO1 may play a role in protecting genomic stability. TAO proteins possess MAPK kinase kinase activity. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The TAO1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270805 [Multi-domain]  Cd Length: 317  Bit Score: 71.62  E-value: 6.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   4 MKYMNKQQcieRDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGG--DLRYHLQQNVQFSEDTVrlyIC 81
Cdd:cd06635   58 MSYSGKQS---NEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSasDLLEVHKKPLQEIEIAA---IT 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMAL-ALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDgerATALAGTKPYMAPEIFHSFVNGgtGYSFEVD 160
Cdd:cd06635  132 HGALqGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSASIASP---ANSFVGTPYWMAPEVILAMDEG--QYDGKVD 206
                        170       180       190
                 ....*....|....*....|....*....|..
gi 247269852 161 WWSVGVMAYELLRgwRPYDIHSSNAVESLVQL 192
Cdd:cd06635  207 VWSLGITCIELAE--RKPPLFNMNAMSALYHI 236
PKc_TNNI3K cd14064
Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase; ...
1-228 6.32e-14

Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TNNI3K, also called cardiac ankyrin repeat kinase (CARK), is a cardiac-specific troponin I-interacting kinase that promotes cardiac myogenesis, improves cardiac performance, and protects the myocardium from ischemic injury. It contains N-terminal ankyrin repeats, a catalytic kinase domain, and a C-terminal serine-rich domain. TNNI3K exerts a disease-accelerating effect on cardiac dysfunction and reduced survival in mouse models of cardiomyopathy. The TNNI3K subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270966 [Multi-domain]  Cd Length: 254  Bit Score: 71.02  E-value: 6.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIER---------DEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVV-DLLLGGDL--RYHLQQN 68
Cdd:cd14064    9 VYKGRCRNKIVAIKRyrantycskSDVDMFCREVSILCRLNHPCVIQFVGACLDDPSQFAIVtQYVSGGSLfsLLHEQKR 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  69 VQFSEDTVRLYIcEMALALDYLR--SQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIK--DGERATALAGTKPYMAPEI 144
Cdd:cd14064   89 VIDLQSKLIIAV-DVAKGMEYLHnlTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQslDEDNMTKQPGNLRWMAPEV 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 145 FHSfvngGTGYSFEVDWWSVGVMAYELLRGWRPYDiHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRF 224
Cdd:cd14064  168 FTQ----CTRYSIKADVFSYALCLWELLTGEIPFA-HLKPAAAAADMAYHHIRPPIGYSIPKPISSLLMRGWNAEPESRP 242

                 ....
gi 247269852 225 SSLQ 228
Cdd:cd14064  243 SFVE 246
STKc_Raf cd14062
Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) ...
58-178 7.90e-14

Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Raf kinases act as mitogen-activated protein kinase kinase kinases (MAP3Ks, MKKKs, MAPKKKs), which phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. They function in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. Aberrant expression or activation of components in this pathway are associated with tumor initiation, progression, and metastasis. Raf proteins contain a Ras binding domain, a zinc finger cysteine-rich domain, and a catalytic kinase domain. Vertebrates have three Raf isoforms (A-, B-, and C-Raf) with different expression profiles, modes of regulation, and abilities to function in the ERK cascade, depending on cellular context and stimuli. They have essential and non-overlapping roles during embryo- and organogenesis. Knockout of each isoform results in a lethal phenotype or abnormality in most mouse strains. The Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270964 [Multi-domain]  Cd Length: 253  Bit Score: 70.50  E-value: 7.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  58 GGDLRYHLQ-QNVQFSEDTVrLYIC-EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATII---KDGERATA 132
Cdd:cd14062   72 GSSLYKHLHvLETKFEMLQL-IDIArQTAQGMDYLHAKNIIHRDLKSNNIFLHEDLTVKIGDFGLATVKtrwSGSQQFEQ 150
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 247269852 133 LAGTKPYMAPEIFHsfVNGGTGYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd14062  151 PTGSILWMAPEVIR--MQDENPYSFQSDVYAFGIVLYELLTGQLPY 194
STKc_TAO2 cd06634
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2; STKs catalyze ...
4-226 1.00e-13

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Human TAO2 is also known as prostate-derived Ste20-like kinase (PSK) and was identified in a screen for overexpressed RNAs in prostate cancer. TAO2 possesses mitogen-activated protein kinase (MAPK) kinase kinase activity and activates both p38 and c-Jun N-terminal kinase (JNK), by phosphorylating and activating their respective MAP/ERK kinases, MEK3/MEK6 and MKK4/MKK7. It contains a long C-terminal extension with autoinhibitory segments, and is activated by the release of this inhibition and the phosphorylation of its activation loop serine. TAO2 functions as a regulator of actin cytoskeletal and microtubule organization. In addition, it regulates the transforming growth factor-activated kinase 1 (TAK1), which is a MAPKKK that plays an essential role in the signaling pathways of tumor necrosis factor, interleukin 1, and Toll-like receptor. The TAO2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270804 [Multi-domain]  Cd Length: 308  Bit Score: 71.21  E-value: 1.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   4 MKYMNKQQcieRDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGG--DLRYHLQQNVQFSEDTVrlyIC 81
Cdd:cd06634   48 MSYSGKQS---NEKWQDIIKEVKFLQKLRHPNTIEYRGCYLREHTAWLVMEYCLGSasDLLEVHKKPLQEVEIAA---IT 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMAL-ALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDgerATALAGTKPYMAPEIFHSFVNGgtGYSFEVD 160
Cdd:cd06634  122 HGALqGLAYLHSHNMIHRDVKAGNILLTEPGLVKLGDFGSASIMAP---ANSFVGTPYWMAPEVILAMDEG--QYDGKVD 196
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 161 WWSVGVMAYELlrGWRPYDIHSSNAVESLVQLFSTVS-VQYVPTWSKEMVALLRKLLTVNPEHRFSS 226
Cdd:cd06634  197 VWSLGITCIEL--AERKPPLFNMNAMSALYHIAQNESpALQSGHWSEYFRNFVDSCLQKIPQDRPTS 261
STKc_CDK5 cd07839
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5; STKs ...
20-233 1.09e-13

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK5 is unusual in that it is regulated by non-cyclin proteins, p35 and p39. It is highly expressed in the nervous system and is critical in normal neural development and function. It plays a role in neuronal migration and differentiation, and is also important in synaptic plasticity and learning. CDK5 also participates in protecting against cell death and promoting angiogenesis. Impaired CDK5 activity is implicated in Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease and acute neuronal injury. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143344 [Multi-domain]  Cd Length: 284  Bit Score: 70.54  E-value: 1.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  20 NVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLlGGDL-RYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHR 98
Cdd:cd07839   45 SALREICLLKELKHKNIVRLYDVLHSDKKLTLVFEYC-DQDLkKYFDSCNGDIDPEIVKSFMFQLLKGLAFCHSHNVLHR 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  99 DVKPDNILLDEQGHAHLTDFNIATIIKDGERA-TALAGTKPYMAPEIFHsfvnGGTGYSFEVDWWSVGVMAYELLRGWRP 177
Cdd:cd07839  124 DLKPQNLLINKNGELKLADFGLARAFGIPVRCySAEVVTLWYRPPDVLF----GAKLYSTSIDMWSAGCIFAELANAGRP 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 178 ----YDIH-------------SSNAVESLVQLF----------STVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDM 230
Cdd:cd07839  200 lfpgNDVDdqlkrifrllgtpTEESWPGVSKLPdykpypmypaTTSLVNVVPKLNSTGRDLLQNLLVCNPVQRISAEEAL 279

                 ...
gi 247269852 231 QTA 233
Cdd:cd07839  280 QHP 282
PTKc_Jak3_rpt2 cd05081
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 3; PTKs catalyze the ...
16-172 1.40e-13

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak3 is expressed only in hematopoietic cells. It binds the shared receptor subunit common gamma chain and thus, is essential in the signaling of cytokines that use it such as IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Jak3 is important in lymphoid development and myeloid cell differentiation. Inactivating mutations in Jak3 have been reported in humans with severe combined immunodeficiency (SCID). Jak3 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270665 [Multi-domain]  Cd Length: 283  Bit Score: 70.31  E-value: 1.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  16 DEVRNVFRELEILQEIEHVFLVN---LWYSfQDEEDMFMVVDLLLGGDLRYHLQQN-VQFSEDTVRLYICEMALALDYLR 91
Cdd:cd05081   47 DQQRDFQREIQILKALHSDFIVKyrgVSYG-PGRRSLRLVMEYLPSGCLRDFLQRHrARLDASRLLLYSSQICKGMEYLG 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  92 SQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATAL--AGTKP--YMAPEIFHSFVnggtgYSFEVDWWSVGVM 167
Cdd:cd05081  126 SRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVrePGQSPifWYAPESLSDNI-----FSRQSDVWSFGVV 200

                 ....*
gi 247269852 168 AYELL 172
Cdd:cd05081  201 LYELF 205
STKc_MPK1 cd07857
Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1; ...
18-275 1.44e-13

Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPKs MPK1 from Saccharomyces cerevisiae, Pmk1 from Schizosaccharomyces pombe, and similar proteins. MPK1 (also called Slt2) and Pmk1 (also called Spm1) are stress-activated MAPKs that regulate the cell wall integrity pathway, and are therefore important in the maintainance of cell shape, cell wall construction, morphogenesis, and ion homeostasis. MPK1 is activated in response to cell wall stress including heat stimulation, osmotic shock, UV irradiation, and any agents that interfere with cell wall biogenesis such as chitin antagonists, caffeine, or zymolase. MPK1 is regulated by the MAP2Ks Mkk1/2, which are regulated by the MAP3K Bck1. Pmk1 is also activated by multiple stresses including elevated temperatures, hyper- or hypotonic stress, glucose deprivation, exposure to cell-wall damaging compounds, and oxidative stress. It is regulated by the MAP2K Pek1, which is regulated by the MAP3K Mkh1. MAPKs are important mediators of cellular responses to extracellular signals. The MPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173750 [Multi-domain]  Cd Length: 332  Bit Score: 70.90  E-value: 1.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  18 VRNVF----------RELEILQEI-EHVFLVNL------WYSFQDEEDMFMVvdlLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd07857   35 ITNVFskkilakralRELKLLRHFrGHKNITCLydmdivFPGNFNELYLYEE---LMEADLHQIIRSGQPLTDAHFQSFI 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDG-----ERATALAGTKPYMAPEIFHSFvnggTGY 155
Cdd:cd07857  112 YQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSENpgenaGFMTEYVATRWYRAPEIMLSF----QSY 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 156 SFEVDWWSVGVMAYELLrGWRPY--------------------------DIHSSNAVESLVQLFSTVSVQYV---PTWSK 206
Cdd:cd07857  188 TKAIDVWSVGCILAELL-GRKPVfkgkdyvdqlnqilqvlgtpdeetlsRIGSPKAQNYIRSLPNIPKKPFEsifPNANP 266
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 247269852 207 EMVALLRKLLTVNPEHRFsSLQDMQTAPSLAhvLWDDLSEKKVepgfvpnkgrlhCDPTFELEEMILES 275
Cdd:cd07857  267 LALDLLEKLLAFDPTKRI-SVEEALEHPYLA--IWHDPDDEPV------------CQKPFDFSFESEDS 320
STKc_JNK cd07850
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; STKs catalyze the ...
22-174 1.63e-13

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. They are also essential regulators of physiological and pathological processes and are involved in the pathogenesis of several diseases such as diabetes, atherosclerosis, stroke, Parkinson's and Alzheimer's. Vetebrates harbor three different JNK genes (Jnk1, Jnk2, and Jnk3) that are alternatively spliced to produce at least 10 isoforms. JNKs are specifically activated by the MAPK kinases MKK4 and MKK7, which are in turn activated by upstream MAPK kinase kinases as a result of different stimuli including stresses such as ultraviolet (UV) irradiation, hyperosmolarity, heat shock, or cytokines. JNKs activate a large number of different substrates based on specific stimulus, cell type, and cellular condition, and may be implicated in seemingly contradictory functions. The JNK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270840 [Multi-domain]  Cd Length: 337  Bit Score: 70.52  E-value: 1.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  22 FRELEILQEIEH---VFLVNLWY---SFQDEEDMFMVVDLLlggdlRYHLQQNVQFSEDTVRL--YICEMALALDYLRSQ 93
Cdd:cd07850   47 YRELVLMKLVNHkniIGLLNVFTpqkSLEEFQDVYLVMELM-----DANLCQVIQMDLDHERMsyLLYQMLCGIKHLHSA 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  94 HIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLR 173
Cdd:cd07850  122 GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL-----GMGYKENVDIWSVGCIMGEMIR 196

                 .
gi 247269852 174 G 174
Cdd:cd07850  197 G 197
STKc_B-Raf cd14151
Catalytic domain of the Serine/Threonine Kinase, B-Raf (Rapidly Accelerated Fibrosarcoma) ...
24-178 1.70e-13

Catalytic domain of the Serine/Threonine Kinase, B-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. B-Raf activates ERK with the strongest magnitude, compared with other Raf kinases. Mice embryos deficient in B-Raf die around midgestation due to vascular hemorrhage caused by apoptotic endothelial cells. Mutations in B-Raf have been implicated in initiating tumorigenesis and tumor progression, and are found in malignant cutaneous melanoma, papillary thyroid cancer, as well as in ovarian and colorectal carcinomas. Most oncogenic B-Raf mutations are located at the activation loop of the kinase and surrounding regions; the V600E mutation accounts for around 90% of oncogenic mutations. The V600E mutant constitutively activates MEK, resulting in sustained activation of ERK. B-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. They function in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The B-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271053 [Multi-domain]  Cd Length: 274  Bit Score: 70.09  E-value: 1.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  24 ELEILQEIEHVFLVnLWYSFQDEEDMFMVVDLLLGGDLRYHLQ-QNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKP 102
Cdd:cd14151   54 EVGVLRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHLHiIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKS 132
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 247269852 103 DNILLDEQGHAHLTDFNIATI---IKDGERATALAGTKPYMAPEIFHsfVNGGTGYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd14151  133 NNIFLHEDLTVKIGDFGLATVksrWSGSHQFEQLSGSILWMAPEVIR--MQDKNPYSFQSDVYAFGIVLYELMTGQLPY 209
PTKc_Syk cd05116
Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; PTKs catalyze the ...
15-223 1.75e-13

Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Syk is a cytoplasmic (or nonreceptor) PTK containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. Syk was first cloned from the spleen, and its function in hematopoietic cells is well-established. It is involved in the signaling downstream of activated receptors (including B-cell and Fc receptors) that contain ITAMs (immunoreceptor tyr activation motifs), leading to processes such as cell proliferation, differentiation, survival, adhesion, migration, and phagocytosis. More recently, Syk expression has been detected in other cell types (including epithelial cells, vascular endothelial cells, neurons, hepatocytes, and melanocytes), suggesting a variety of biological functions in non-immune cells. Syk plays a critical role in maintaining vascular integrity and in wound healing during embryogenesis. It also regulates Vav3, which is important in osteoclast function including bone development. In breast epithelial cells, where Syk acts as a negative regulator for EGFR signaling, loss of Syk expression is associated with abnormal proliferation during cancer development suggesting a potential role as a tumor suppressor. In mice, Syk has been shown to inhibit malignant transformation of mammary epithelial cells induced with murine mammary tumor virus (MMTV). The Syk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133247 [Multi-domain]  Cd Length: 257  Bit Score: 69.61  E-value: 1.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  15 RDEVrnvFRELEILQEIEHVFLVNLwYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQH 94
Cdd:cd05116   40 KDEL---LREANVMQQLDNPYIVRM-IGICEAESWMLVMEMAELGPLNKFLQKNRHVTEKNITELVHQVSMGMKYLEESN 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  95 IIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTK----PYMAPEI--FHSFvnggtgySFEVDWWSVGVMA 168
Cdd:cd05116  116 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGkwpvKWYAPECmnYYKF-------SSKSDVWSFGVLM 188
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 169 YELLR-GWRPYDIHSSNAVESLVQlfSTVSVQYVPTWSKEMVALLRKLLTVNPEHR 223
Cdd:cd05116  189 WEAFSyGQKPYKGMKGNEVTQMIE--KGERMECPAGCPPEMYDLMKLCWTYDVDER 242
STKc_CK1 cd14016
Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1; STKs catalyze the ...
2-126 1.91e-13

Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CK1 phosphorylates a variety of substrates including enzymes, transcription and splice factors, cytoskeletal proteins, viral oncogenes, receptors, and membrane-associated proteins. There are mutliple isoforms of CK1 and in mammals, seven isoforms (alpha, beta, gamma1-3, delta, and epsilon) have been characterized. These isoforms differ mainly in the length and structure of their C-terminal non-catalytic region. Some isoforms have several splice variants such as the long (L) and short (S) variants of CK1alpha. CK1 proteins are involved in the regulation of many cellular processes including membrane transport processes, circadian rhythm, cell division, apoptosis, and the development of cancer and neurodegenerative diseases. The CK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270918 [Multi-domain]  Cd Length: 266  Bit Score: 69.79  E-value: 1.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKymnkqqcIERDEVRN--VFRELEILQEIE-HVFLVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQ-NVQFSEDTVR 77
Cdd:cd14016   28 VAIK-------IEKKDSKHpqLEYEAKVYKLLQgGPGIPRLYWFGQEGDYNVMVMDLL-GPSLEDLFNKcGRKFSLKTVL 99
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 247269852  78 LYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAH---LTDFNIATIIKD 126
Cdd:cd14016  100 MLADQMISRLEYLHSKGYIHRDIKPENFLMGLGKNSNkvyLIDFGLAKKYRD 151
STKc_PCTAIRE_like cd07844
Catalytic domain of PCTAIRE-like Serine/Threonine Kinases; STKs catalyze the transfer of the ...
23-206 2.18e-13

Catalytic domain of PCTAIRE-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-like proteins show unusual expression patterns with high levels in post-mitotic tissues, suggesting that they may be involved in regulating post-mitotic cellular events. They share sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The association of PCTAIRE-like proteins with cyclins has not been widely studied, although PFTAIRE-1 has been shown to function as a CDK which is regulated by cyclin D3 as well as the membrane-associated cyclin Y. The PCTAIRE-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270835 [Multi-domain]  Cd Length: 286  Bit Score: 69.72  E-value: 2.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQNVQF-SEDTVRLYICEMALALDYLRSQHIIHRDVK 101
Cdd:cd07844   47 REASLLKDLKHANIVTLHDIIHTKKTLTLVFEYL-DTDLKQYMDDCGGGlSMHNVRLFLFQLLRGLAYCHQRRVLHRDLK 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 102 PDNILLDEQGHAHLTDFNIAtiikdgeRATALAG--------TKPYMAPEIFHsfvnGGTGYSFEVDWWSVGVMAYELLR 173
Cdd:cd07844  126 PQNLLISERGELKLADFGLA-------RAKSVPSktysnevvTLWYRPPDVLL----GSTEYSTSLDMWGVGCIFYEMAT 194
                        170       180       190
                 ....*....|....*....|....*....|...
gi 247269852 174 GwRPYDIHSSNAVESLVQLFSTVSVQYVPTWSK 206
Cdd:cd07844  195 G-RPLFPGSTDVEDQLHKIFRVLGTPTEETWPG 226
PTKc_Lyn cd05072
Catalytic domain of the Protein Tyrosine Kinase, Lyn; PTKs catalyze the transfer of the ...
18-191 2.20e-13

Catalytic domain of the Protein Tyrosine Kinase, Lyn; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Lyn is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lyn is expressed in B lymphocytes and myeloid cells. It exhibits both positive and negative regulatory roles in B cell receptor (BCR) signaling. Lyn, as well as Fyn and Blk, promotes B cell activation by phosphorylating ITAMs (immunoreceptor tyr activation motifs) in CD19 and in Ig components of BCR. It negatively regulates signaling by its unique ability to phosphorylate ITIMs (immunoreceptor tyr inhibition motifs) in cell surface receptors like CD22 and CD5. Lyn also plays an important role in G-CSF receptor signaling by phosphorylating a variety of adaptor molecules. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Lyn subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270657 [Multi-domain]  Cd Length: 272  Bit Score: 69.68  E-value: 2.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  18 VRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDL----------RYHLQQNVQFSedtvrlyiCEMALAL 87
Cdd:cd05072   46 VQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEYMAKGSLldflksdeggKVLLPKLIDFS--------AQIAEGM 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  88 DYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERaTALAGTK---PYMAPEIfhsfVNGGTgYSFEVDWWSV 164
Cdd:cd05072  118 AYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEY-TAREGAKfpiKWTAPEA----INFGS-FTIKSDVWSF 191
                        170       180
                 ....*....|....*....|....*...
gi 247269852 165 GVMAYELLR-GWRPYDIHSSNAVESLVQ 191
Cdd:cd05072  192 GILLYEIVTyGKIPYPGMSNSDVMSALQ 219
PKc_DYRK_like cd14133
Catalytic domain of Dual-specificity tYrosine-phosphorylated and -Regulated Kinase-like ...
32-231 2.28e-13

Catalytic domain of Dual-specificity tYrosine-phosphorylated and -Regulated Kinase-like protein kinases; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. This subfamily is composed of the dual-specificity DYRKs and YAK1, as well as the S/T kinases (STKs), HIPKs. DYRKs and YAK1 autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. Proteins in this subfamily play important roles in cell proliferation, differentiation, survival, growth, and development. The DYRK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271035 [Multi-domain]  Cd Length: 262  Bit Score: 69.22  E-value: 2.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  32 EHVFLVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQN--VQFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDE 109
Cdd:cd14133   59 DKYHIVRLKDVFYFKNHLCIVFELL-SQNLYEFLKQNkfQYLSLPRIRKIAQQILEALVFLHSLGLIHCDLKPENILLAS 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 110 QGHAH--LTDFNIATIIKDgeRATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSS---- 183
Cdd:cd14133  138 YSRCQikIIDFGSSCFLTQ--RLYSYIQSRYYRAPEVIL-----GLPYDEKIDMWSLGCILAELYTGEPLFPGASEvdql 210
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 247269852 184 NAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd14133  211 ARIIGTIGIPPAHMLDQGKADDELFVDFLKKLLEIDPKERPTASQALS 258
STKc_SnRK2 cd14662
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
1-225 2.58e-13

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK2 is represented in this cd. SnRK2s are involved in plant response to abiotic stresses and abscisic acid (ABA)-dependent plant development. The SnRK2s subfamily is in turn classed into three subgroups, all 3 of which are represented in this CD. Group 1 comprises kinases not activated by ABA, group 2 - kinases not activated or activated very weakly by ABA (depending on plant species), and group 3 - kinases strongly activated by ABA. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271132 [Multi-domain]  Cd Length: 257  Bit Score: 69.03  E-value: 2.58e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIerDEvrNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14662   27 LVAVKYIERGLKI--DE--NVQREIINHRSLRHPNIIRFKEVVLTPTHLAIVMEYAAGGELFERICNAGRFSEDEARYFF 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLT--DFNIATIIKDGERATALAGTKPYMAPEIFHSFVNGGTgysfE 158
Cdd:cd14662  103 QQLISGVSYCHSMQICHRDLKLENTLLDGSPAPRLKicDFGYSKSSVLHSQPKSTVGTPAYIAPEVLSRKEYDGK----V 178
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 247269852 159 VDWWSVGVMAYELLRGWRPY-DIHSSNAVESLVQlfSTVSVQY-VPTW---SKEMVALLRKLLTVNPEHRFS 225
Cdd:cd14662  179 ADVWSCGVTLYVMLVGAYPFeDPDDPKNFRKTIQ--RIMSVQYkIPDYvrvSQDCRHLLSRIFVANPAKRIT 248
STKc_myosinIIIB_N cd06639
N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIB myosin; STKs catalyze ...
16-240 2.73e-13

N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIB myosin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class IIIB myosin is expressed highly in retina. It is also present in the brain and testis. The human class IIIB myosin gene maps to a region that overlaps the locus for Bardet-Biedl syndrome, which is characterized by dysmorphic extremities, retinal dystrophy, obesity, male hypogenitalism, and renal abnormalities. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain. They may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. They may also function as cargo carriers during light-dependent translocation, in photoreceptor cells, of proteins such as transducin and arrestin. The class III myosin subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270808 [Multi-domain]  Cd Length: 291  Bit Score: 69.64  E-value: 2.73e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  16 DEVRNVFRELE----ILQEI-EHVFLVNLWYSFQDEE-----DMFMVVDLLLGG---DLRYHLQQNVQFSEDTVRLYICE 82
Cdd:cd06639   56 DPISDVDEEIEaeynILRSLpNHPNVVKFYGMFYKADqyvggQLWLVLELCNGGsvtELVKGLLKCGQRLDEAMISYILY 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MAL-ALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE-RATALAGTKPYMAPEIFHSFVNGGTGYSFEVD 160
Cdd:cd06639  136 GALlGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSARlRRNTSVGTPFWMAPEVIACEQQYDYSYDARCD 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 161 WWSVGVMAYELLRGWRP-YDIHSsnaVESLVQLFSTVSvqyvPT------WSKEMVALLRKLLtvnpehrfssLQDMQTA 233
Cdd:cd06639  216 VWSLGITAIELADGDPPlFDMHP---VKALFKIPRNPP----PTllnpekWCRGFSHFISQCL----------IKDFEKR 278

                 ....*..
gi 247269852 234 PSLAHVL 240
Cdd:cd06639  279 PSVTHLL 285
STKc_MAPKAPK5 cd14171
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
49-225 2.80e-13

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 5 (MAPKAP5 or MK5) is also called PRAK (p38-regulated/activated protein kinase). It contains a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK5 is a ubiquitous protein that is implicated in neuronal morphogenesis, cell migration, and tumor angiogenesis. It interacts with PKA, which induces cytoplasmic translocation of MK5. Its substrates includes p53, ERK3/4, Hsp27, and cytosolic phospholipase A2 (cPLA2). The MAPKAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271073 [Multi-domain]  Cd Length: 289  Bit Score: 69.41  E-value: 2.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  49 MFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILL---DEQGHAHLTDFNIATiIK 125
Cdd:cd14171   84 LLIVMELMEGGELFDRISQHRHFTEKQAAQYTKQIALAVQHCHSLNIAHRDLKPENLLLkdnSEDAPIKLCDFGFAK-VD 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 126 DGERATAlAGTKPYMAPEIFH----------SFVNGGTGYSFE--VDWWSVGVMAYELLRGWRPY--DIHSSNAVESLVQ 191
Cdd:cd14171  163 QGDLMTP-QFTPYYVAPQVLEaqrrhrkersGIPTSPTPYTYDksCDMWSLGVIIYIMLCGYPPFysEHPSRTITKDMKR 241
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 247269852 192 LFSTVSVQYvPTWSKEMVA-----LLRKLLTVNPEHRFS 225
Cdd:cd14171  242 KIMTGSYEF-PEEEWSQISemakdIVRKLLCVDPEERMT 279
STKc_Mos cd13979
Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos; STKs catalyze ...
78-178 4.87e-13

Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mos (or c-Mos) is a germ-cell specific kinase that plays roles in both the release of primary arrest and the induction of secondary arrest in oocytes. It is expressed towards the end of meiosis I and is quickly degraded upon fertilization. It is a component of the cytostatic factor (CSF), which is responsible for metaphase II arrest. In addition, Mos activates a phoshorylation cascade that leads to the activation of the p34 subunit of MPF (mitosis-promoting factor or maturation promoting factor), a cyclin-dependent kinase that is responsible for the release of primary arrest in meiosis I. The Mos subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270881 [Multi-domain]  Cd Length: 265  Bit Score: 68.56  E-value: 4.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  78 LYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKD----GERATALAGTKPYMAPEIFHsfvngGT 153
Cdd:cd13979  107 LISLDIARALRFCHSHGIVHLDVKPANILISEQGVCKLCDFGCSVKLGEgnevGTPRSHIGGTYTYRAPELLK-----GE 181
                         90       100
                 ....*....|....*....|....*
gi 247269852 154 GYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd13979  182 RVTPKADIYSFGITLWQMLTRELPY 206
PKc_Mps1 cd14131
Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle ...
1-225 5.10e-13

Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK); Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TTK/Mps1 is a spindle checkpoint kinase that was first discovered due to its necessity in centrosome duplication in budding yeast. It was later found to function in the spindle assembly checkpoint, which monitors the proper attachment of chromosomes to the mitotic spindle. In yeast, substrates of Mps1 include the spindle pole body components Spc98p, Spc110p, and Spc42p. The TTK/Mps1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271033 [Multi-domain]  Cd Length: 271  Bit Score: 68.39  E-value: 5.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNkqqCIERDE--VRNVFRELEILQEIEH-VFLVNLW-YSFQDEED-MFMVVDLllG-GDLRYHLQQNV--QFS 72
Cdd:cd14131   27 IYALKRVD---LEGADEqtLQSYKNEIELLKKLKGsDRIIQLYdYEVTDEDDyLYMVMEC--GeIDLATILKKKRpkPID 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  73 EDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLdEQGHAHLTDFNIAT--------IIKDgeratALAGTKPYMAPE- 143
Cdd:cd14131  102 PNFIRYYWKQMLEAVHTIHEEGIVHSDLKPANFLL-VKGRLKLIDFGIAKaiqndttsIVRD-----SQVGTLNYMSPEa 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 144 IFHSFVNGGTGYSFEV----DWWSVGVMAYELLRGWRPYDiHSSNAVESLVQLFS-TVSVQYVPTWSKEMVALLRKLLTV 218
Cdd:cd14131  176 IKDTSASGEGKPKSKIgrpsDVWSLGCILYQMVYGKTPFQ-HITNPIAKLQAIIDpNHEIEFPDIPNPDLIDVMKRCLQR 254

                 ....*..
gi 247269852 219 NPEHRFS 225
Cdd:cd14131  255 DPKKRPS 261
STKc_NLK cd07853
Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase; STKs catalyze the transfer ...
20-174 5.28e-13

Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NLK is an atypical mitogen-activated protein kinase (MAPK) that is not regulated by a MAPK kinase. It functions downstream of the MAPK kinase kinase Tak1, which also plays a role in activating the JNK and p38 MAPKs. The Tak1/NLK pathways are regulated by Wnts, a family of secreted proteins that is critical in the control of asymmetric division and cell polarity. NLK can phosphorylate transcription factors from the TCF/LEF family, inhibiting their ability to activate the transcription of target genes. In prostate cancer cells, NLK is involved in regulating androgen receptor-mediated transcription and its expression is altered during cancer progression. MAPKs are important mediators of cellular responses to extracellular signals. The NLK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173748 [Multi-domain]  Cd Length: 372  Bit Score: 69.39  E-value: 5.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  20 NVFRELEILQEIEHVFLvnlwysfqdeEDMFMVVDLLlGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRD 99
Cdd:cd07853   60 NVLSALDILQPPHIDPF----------EEIYVVTELM-QSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRD 128
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 100 VKPDNILLDEQGHAHLTDFNIATIIKDGERA--TALAGTKPYMAPEIfhsfVNGGTGYSFEVDWWSVGVMAYELLRG 174
Cdd:cd07853  129 IKPGNLLVNSNCVLKICDFGLARVEEPDESKhmTQEVVTQYYRAPEI----LMGSRHYTSAVDIWSVGCIFAELLGR 201
STKc_LRRK cd14000
Catalytic domain of the Serine/Threonine kinase, Leucine-Rich Repeat Kinase; STKs catalyze the ...
58-228 5.67e-13

Catalytic domain of the Serine/Threonine kinase, Leucine-Rich Repeat Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. Vertebrates contain two members, LRRK1 and LRRK2, which show complementary expression in the brain. Mutations in LRRK2 are linked to both familial and sporadic forms of Parkinson's disease. The normal roles of LRRKs are not clearly defined. They may be involved in mitogen-activated protein kinase (MAPK) pathways, protein translation control, programmed cell death pathways, and cytoskeletal dynamics. The LRRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270902 [Multi-domain]  Cd Length: 275  Bit Score: 68.41  E-value: 5.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  58 GGDLRYHLQQNVQFsedtvrlyicEMALALDYLRSQHIIHRDVKPDNILL-----DEQGHAHLTDFNIATIIKDgERATA 132
Cdd:cd14000  106 FASLGRTLQQRIAL----------QVADGLRYLHSAMIIYRDLKSHNVLVwtlypNSAIIIKIADYGISRQCCR-MGAKG 174
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 133 LAGTKPYMAPEIfhsfVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSS--NAVESLVQLFSTVSvQYVPTWSKEMVA 210
Cdd:cd14000  175 SEGTPGFRAPEI----ARGNVIYNEKVDVFSFGMLLYEILSGGAPMVGHLKfpNEFDIHGGLRPPLK-QYECAPWPEVEV 249
                        170
                 ....*....|....*...
gi 247269852 211 LLRKLLTVNPEHRFSSLQ 228
Cdd:cd14000  250 LMKKCWKENPQQRPTAVT 267
STKc_IRAK1 cd14159
Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 1; ...
2-182 7.20e-13

Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain, and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK1 plays a role in the activation of IRF3/7, STAT, and NFkB. It mediates IL-6 and IFN-gamma responses following IL-1 and IL-18 stimulation, respectively. It also plays an essential role in IFN-alpha induction downstream of TLR7 and TLR9. The IRAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271061 [Multi-domain]  Cd Length: 296  Bit Score: 68.31  E-value: 7.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNVFR-ELEILQEIEHVFLVNL-WYSFQDEEdmFMVVDLLL-GGDLRYHLQQNVQFSEDTV-- 76
Cdd:cd14159   19 YAVKRLKEDSELDWSVVKNSFLtEVEKLSRFRHPNIVDLaGYSAQQGN--YCLIYVYLpNGSLEDRLHCQVSCPCLSWsq 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  77 RLYICE-MALALDYLRSQH--IIHRDVKPDNILLDEQGHAHLTDFNIATI---IKDGERATALA------GTKPYMAPEi 144
Cdd:cd14159   97 RLHVLLgTARAIQYLHSDSpsLIHGDVKSSNILLDAALNPKLGDFGLARFsrrPKQPGMSSTLArtqtvrGTLAYLPEE- 175
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 247269852 145 fhsFVNGGTgYSFEVDWWSVGVMAYELLRGWRPYDIHS 182
Cdd:cd14159  176 ---YVKTGT-LSVEIDVYSFGVVLLELLTGRRAMEVDS 209
STKc_CDK10 cd07845
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10; STKs ...
23-229 7.93e-13

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK10, also called PISSLRE, is essential for cell growth and proliferation, and acts through the G2/M phase of the cell cycle. CDK10 has also been identified as an important factor in endocrine therapy resistance in breast cancer. CDK10 silencing increases the transcription of c-RAF and the activation of the p42/p44 MAPK pathway, which leads to antiestrogen resistance. Patients who express low levels of CDK10 relapse early on tamoxifen. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK10 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173742 [Multi-domain]  Cd Length: 309  Bit Score: 68.55  E-value: 7.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDE--EDMFMVV-----DLllgGDLRYHLQQnvQFSEDTVRLYICEMALALDYLRSQHI 95
Cdd:cd07845   55 REITLLLNLRHPNIVELKEVVVGKhlDSIFLVMeyceqDL---ASLLDNMPT--PFSESQVKCLMLQLLRGLQYLHENFI 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  96 IHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERA-TALAGTKPYMAPEIfhsfVNGGTGYSFEVDWWSVGVMAYELLRG 174
Cdd:cd07845  130 IHRDLKVSNLLLTDKGCLKIADFGLARTYGLPAKPmTPKVVTLWYRAPEL----LLGCTTYTTAIDMWAVGCILAELLAH 205
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 175 wRPYDIHSS--NAVESLVQLFSTVSVQYVPTWSKEMVA---LLRKLLTVNPEHRFSSLQD 229
Cdd:cd07845  206 -KPLLPGKSeiEQLDLIIQLLGTPNESIWPGFSDLPLVgkfTLPKQPYNNLKHKFPWLSE 264
STKc_WNK cd13983
Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase; STKs catalyze ...
14-178 8.82e-13

Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNKs comprise a subfamily of STKs with an unusual placement of a catalytic lysine relative to all other protein kinases. They are critical in regulating ion balance and are thus, important components in the control of blood pressure. They are also involved in cell signaling, survival, proliferation, and organ development. WNKs are activated by hyperosmotic or low-chloride hypotonic stress and they function upstream of SPAK and OSR1 kinases, which regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. There are four vertebrate WNKs which show varying expression patterns. WNK1 and WNK2 are widely expressed while WNK3 and WNK4 show a more restricted expression pattern. Because mutations in human WNK1 and WNK4 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension (due to increased sodium reabsorption) and hyperkalemia (due to impaired renal potassium secretion), there are more studies conducted on these two proteins, compared to WNK2 and WNK3. The WNK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270885 [Multi-domain]  Cd Length: 258  Bit Score: 67.64  E-value: 8.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  14 ERDEVRNVFRELEILQEIEH---VFLVNLWYSfQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYL 90
Cdd:cd13983   40 PKAERQRFKQEIEILKSLKHpniIKFYDSWES-KSKKEVIFITELMTSGTLKQYLKRFKRLKLKVIKSWCRQILEGLNYL 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  91 RSQH--IIHRDVKPDNILLD-EQGHAHLTDFNIATIIKDGERATALaGTKPYMAPEIFhsfvngGTGYSFEVDWWSVGVM 167
Cdd:cd13983  119 HTRDppIIHRDLKCDNIFINgNTGEVKIGDLGLATLLRQSFAKSVI-GTPEFMAPEMY------EEHYDEKVDIYAFGMC 191
                        170
                 ....*....|.
gi 247269852 168 AYELLRGWRPY 178
Cdd:cd13983  192 LLEMATGEYPY 202
STKc_NIK cd13991
Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK); STKs ...
49-178 1.21e-12

Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NIK, also called mitogen activated protein kinase kinase kinase 14 (MAP3K14), phosphorylates and activates Inhibitor of NF-KappaB Kinase (IKK) alpha, which is a regulator of NF-kB proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. NIK is essential in the IKKalpha-mediated non-canonical NF-kB signaling pathway, in which IKKalpha processes the IkB-like C-terminus of NF-kB2/p100 to produce p52, allowing the p52/RelB dimer to migrate to the nucleus where it regulates gene transcription. NIK also plays an important role in Toll-like receptor 7/9 signaling cascades. The NIK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270893 [Multi-domain]  Cd Length: 268  Bit Score: 67.15  E-value: 1.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  49 MFMvvDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQG-HAHLTDFNIA-TIIKD 126
Cdd:cd13991   75 IFM--DLKEGGSLGQLIKEQGCLPEDRALHYLGQALEGLEYLHSRKILHGDVKADNVLLSSDGsDAFLCDFGHAeCLDPD 152
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 127 GERATALA-----GTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd13991  153 GLGKSLFTgdyipGTETHMAPEVVL-----GKPCDAKVDVWSSCCMMLHMLNGCHPW 204
STKc_ERK1_2_like cd07849
Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine ...
23-223 1.50e-12

Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the mitogen-activated protein kinases (MAPKs) ERK1, ERK2, baker's yeast Fus3, and similar proteins. MAPK pathways are important mediators of cellular responses to extracellular signals. ERK1/2 activation is preferentially by mitogenic factors, differentiation stimuli, and cytokines, through a kinase cascade involving the MAPK kinases MEK1/2 and a MAPK kinase kinase from the Raf family. ERK1/2 have numerous substrates, many of which are nuclear and participate in transcriptional regulation of many cellular processes. They regulate cell growth, cell proliferation, and cell cycle progression from G1 to S phase. Although the distinct roles of ERK1 and ERK2 have not been fully determined, it is known that ERK2 can maintain most functions in the absence of ERK1, and that the deletion of ERK2 is embryonically lethal. The MAPK, Fus3, regulates yeast mating processes including mating-specific gene expression, G1 arrest, mating projection, and cell fusion. This ERK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270839 [Multi-domain]  Cd Length: 336  Bit Score: 67.71  E-value: 1.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLW-----YSFQDEEDMFMVVDLLlGGDLrYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIH 97
Cdd:cd07849   52 REIKILLRFKHENIIGILdiqrpPTFESFKDVYIVQELM-ETDL-YKLIKTQHLSNDHIQYFLYQILRGLKYIHSANVLH 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  98 RDVKPDNILLDEQGHAHLTDFNIATIIKDGERATAL----AGTKPYMAPEIFHSFvnggTGYSFEVDWWSVGVMAYELLR 173
Cdd:cd07849  130 RDLKPSNLLLNTNCDLKICDFGLARIADPEHDHTGFlteyVATRWYRAPEIMLNS----KGYTKAIDIWSVGCILAEMLS 205
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 247269852 174 GwRP--------------------------YDIHSSNAVESLVQL--FSTVS-VQYVPTWSKEMVALLRKLLTVNPEHR 223
Cdd:cd07849  206 N-RPlfpgkdylhqlnlilgilgtpsqedlNCIISLKARNYIKSLpfKPKVPwNKLFPNADPKALDLLDKMLTFNPHKR 283
PTKc_Btk_Bmx cd05113
Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow ...
7-191 1.69e-12

Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Btk and Bmx (also named Etk) are members of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, Btk contains the Tec homology (TH) domain with proline-rich and zinc-binding regions. Btk is expressed in B-cells, and a variety of myeloid cells including mast cells, platelets, neutrophils, and dendrictic cells. It interacts with a variety of partners, from cytosolic proteins to nuclear transcription factors, suggesting a diversity of functions. Stimulation of a diverse array of cell surface receptors, including antigen engagement of the B-cell receptor, leads to PH-mediated membrane translocation of Btk and subsequent phosphorylation by Src kinase and activation. Btk plays an important role in the life cycle of B-cells including their development, differentiation, proliferation, survival, and apoptosis. Mutations in Btk cause the primary immunodeficiency disease, X-linked agammaglobulinaemia (XLA) in humans. Bmx is primarily expressed in bone marrow and the arterial endothelium, and plays an important role in ischemia-induced angiogenesis. It facilitates arterial growth, capillary formation, vessel maturation, and bone marrow-derived endothelial progenitor cell mobilization. The Btk/Bmx subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173657 [Multi-domain]  Cd Length: 256  Bit Score: 66.83  E-value: 1.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   7 MNKQQCIERDEVrnvFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC-EMAL 85
Cdd:cd05113   35 MIKEGSMSEDEF---IEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRKRFQTQQLLEMCkDVCE 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  86 ALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKP--YMAPEIFHSFvnggtGYSFEVDWWS 163
Cdd:cd05113  112 AMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPvrWSPPEVLMYS-----KFSSKSDVWA 186
                        170       180       190
                 ....*....|....*....|....*....|
gi 247269852 164 VGVMAYELLR-GWRPYD-IHSSNAVESLVQ 191
Cdd:cd05113  187 FGVLMWEVYSlGKMPYErFTNSETVEHVSQ 216
STKc_SnRK2-3 cd14665
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
1-225 1.75e-12

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2, group 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK2 is represented in this cd. SnRK2s are involved in plant response to abiotic stresses and abscisic acid (ABA)-dependent plant development. The SnRK2s subfamily is in turn classed into three subgroups, all 3 of which are represented in this CD. Group 1 comprises kinases not activated by ABA, group 2 - kinases not activated or activated very weakly by ABA (depending on plant species), and group 3 - kinases strongly activated by ABA. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271135 [Multi-domain]  Cd Length: 257  Bit Score: 66.55  E-value: 1.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIerDEvrNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd14665   27 LVAVKYIERGEKI--DE--NVQREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYAAGGELFERICNAGRFSEDEARFFF 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLT--DFNI--ATIIKDGERATalAGTKPYMAPEIFHSfvnggTGYS 156
Cdd:cd14665  103 QQLISGVSYCHSMQICHRDLKLENTLLDGSPAPRLKicDFGYskSSVLHSQPKST--VGTPAYIAPEVLLK-----KEYD 175
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 247269852 157 FEV-DWWSVGVMAYELLRGWRPY-DIHSSNAVESLVQlfSTVSVQY-VPTW---SKEMVALLRKLLTVNPEHRFS 225
Cdd:cd14665  176 GKIaDVWSCGVTLYVMLVGAYPFeDPEEPRNFRKTIQ--RILSVQYsIPDYvhiSPECRHLISRIFVADPATRIT 248
STKc_CDK12 cd07864
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12; STKs ...
23-231 2.09e-12

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK12 is also called Cdc2-related protein kinase 7 (CRK7) or Cdc2-related kinase arginine/serine-rich (CrkRS). It is a unique CDK that contains an RS domain, which is predominantly found in splicing factors. CDK12 is widely expressed in tissues. It interacts with cyclins L1 and L2, and plays roles in regulating transcription and alternative splicing. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK12 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270847 [Multi-domain]  Cd Length: 302  Bit Score: 67.14  E-value: 2.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEED-------------MFMVVDLLLGGDLRYHLqqnVQFSEDTVRLYICEMALALDY 89
Cdd:cd07864   55 REIKILRQLNHRSVVNLKEIVTDKQDaldfkkdkgafylVFEYMDHDLMGLLESGL---VHFSEDHIKSFMKQLLEGLNY 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  90 LRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATII-KDGERA-TALAGTKPYMAPEIFHsfvnGGTGYSFEVDWWSVGVM 167
Cdd:cd07864  132 CHKKNFLHRDIKCSNILLNNKGQIKLADFGLARLYnSEESRPyTNKVITLWYRPPELLL----GEERYGPAIDVWSCGCI 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 168 AYELLRGwRPydIHSSNAVESLVQLFSTV----------SVQYVPTWS--------------------KEMVALLRKLLT 217
Cdd:cd07864  208 LGELFTK-KP--IFQANQELAQLELISRLcgspcpavwpDVIKLPYFNtmkpkkqyrrrlreefsfipTPALDLLDHMLT 284
                        250
                 ....*....|....
gi 247269852 218 VNPEHRFSSLQDMQ 231
Cdd:cd07864  285 LDPSKRCTAEQALN 298
PK_STRAD cd08216
Pseudokinase domain of STE20-related kinase adapter protein; The pseudokinase domain shows ...
3-178 2.30e-12

Pseudokinase domain of STE20-related kinase adapter protein; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. STRAD forms a complex with the scaffolding protein MO25, and the serine/threonine kinase (STK), LKB1, resulting in the activation of the kinase. In the complex, LKB1 phosphorylates and activates adenosine monophosphate-activated protein kinases (AMPKs), which regulate cell energy metabolism and cell polarity. LKB1 is a tumor suppressor linked to the rare inherited disease, Peutz-Jeghers syndrome, which is characterized by a predisposition to benign polyps and hyperpigmentation of the buccal mucosa. There are two forms of STRAD, alpha and beta, that complex with LKB1 and MO25. The structure of STRAD-alpha is available and shows that this protein binds ATP, has an ordered activation loop, and adopts a closed conformation typical of fully active protein kinases. It does not possess activity due to nonconservative substitutions of essential catalytic residues. ATP binding enhances the affinity of STRAD for MO25. The conformation of STRAD-alpha stabilized through ATP and MO25 may be needed to activate LKB1. The STRAD subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270856 [Multi-domain]  Cd Length: 315  Bit Score: 66.93  E-value: 2.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRnVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQN--VQFSEDTVRLYI 80
Cdd:cd08216   29 AVKKINLESDSKEDLKF-LQQEILTSRQLQHPNILPYVTSFVVDNDLYVVTPLMAYGSCRDLLKTHfpEGLPELAIAFIL 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAT-IIKDGERATALAG-----TK--PYMAPEI----FHsf 148
Cdd:cd08216  108 RDVLNALEYIHSKGYIHRSVKASHILISGDGKVVLSGLRYAYsMVKHGKRQRVVHDfpkssEKnlPWLSPEVlqqnLL-- 185
                        170       180       190
                 ....*....|....*....|....*....|
gi 247269852 149 vnggtGYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd08216  186 -----GYNEKSDIYSVGITACELANGVVPF 210
STKc_Pho85 cd07836
Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Pho85; ...
23-231 2.42e-12

Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Pho85; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Pho85 is a multifunctional CDK in yeast. It is regulated by 10 different cyclins (Pcls) and plays a role in G1 progression, cell polarity, phosphate and glycogen metabolism, gene expression, and in signaling changes in the environment. It is not essential for yeast viability and is the functional homolog of mammalian CDK5, which plays a role in central nervous system development. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The Pho85 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143341 [Multi-domain]  Cd Length: 284  Bit Score: 66.74  E-value: 2.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLwYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQ---FSEDTVRLYICEMALALDYLRSQHIIHRD 99
Cdd:cd07836   47 REISLMKELKHENIVRL-HDVIHTENKLMLVFEYMDKDLKKYMDTHGVrgaLDPNTVKSFTYQLLKGIAFCHENRVLHRD 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 100 VKPDNILLDEQGHAHLTDFNIAtiikdgeRATAL--------AGTKPYMAPEIFHsfvnGGTGYSFEVDWWSVGVMAYEL 171
Cdd:cd07836  126 LKPQNLLINKRGELKLADFGLA-------RAFGIpvntfsneVVTLWYRAPDVLL----GSRTYSTSIDIWSVGCIMAEM 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 172 LRGwRPYDIHSSNAvESLVQLF---------------------------STVSVQYV-PTWSKEMVALLRKLLTVNPEHR 223
Cdd:cd07836  195 ITG-RPLFPGTNNE-DQLLKIFrimgtptestwpgisqlpeykptfpryPPQDLQQLfPHADPLGIDLLHRLLQLNPELR 272

                 ....*...
gi 247269852 224 FSSLQDMQ 231
Cdd:cd07836  273 ISAHDALQ 280
PTKc_Itk cd05112
Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase; PTKs ...
24-189 3.60e-12

Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Itk, also known as Tsk or Emt, is a member of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, Itk contains the Tec homology (TH) domain containing one proline-rich region and a zinc-binding region. Itk is expressed in T-cells and mast cells, and is important in their development and differentiation. Of the three Tec kinases expressed in T-cells, Itk plays the predominant role in T-cell receptor (TCR) signaling. It is activated by phosphorylation upon TCR crosslinking and is involved in the pathway resulting in phospholipase C-gamma1 activation and actin polymerization. It also plays a role in the downstream signaling of the T-cell costimulatory receptor CD28, the T-cell surface receptor CD2, and the chemokine receptor CXCR4. In addition, Itk is crucial for the development of T-helper(Th)2 effector responses. The Itk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133243 [Multi-domain]  Cd Length: 256  Bit Score: 65.74  E-value: 3.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  24 ELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQ-QNVQFSEDTVR---LYICEmalALDYLRSQHIIHRD 99
Cdd:cd05112   49 EAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRtQRGLFSAETLLgmcLDVCE---GMAYLEEASVIHRD 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 100 VKPDNILLDEQGHAHLTDFNIATIIKDgERATALAGTK---PYMAPEIFhSFVNggtgYSFEVDWWSVGVMAYELL-RGW 175
Cdd:cd05112  126 LAARNCLVGENQVVKVSDFGMTRFVLD-DQYTSSTGTKfpvKWSSPEVF-SFSR----YSSKSDVWSFGVLMWEVFsEGK 199
                        170
                 ....*....|....*
gi 247269852 176 RPYDIHS-SNAVESL 189
Cdd:cd05112  200 IPYENRSnSEVVEDI 214
PTKc_EGFR_like cd05057
Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases; PTKs ...
21-179 4.39e-12

Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EGFR (HER, ErbB) subfamily members include EGFR (HER1, ErbB1), HER2 (ErbB2), HER3 (ErbB3), HER4 (ErbB4), and similar proteins. They are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, resulting in the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Collectively, they can recognize a variety of ligands including EGF, TGFalpha, and neuregulins, among others. All four subfamily members can form homo- or heterodimers. HER3 contains an impaired kinase domain and depends on its heterodimerization partner for activation. EGFR subfamily members are involved in signaling pathways leading to a broad range of cellular responses including cell proliferation, differentiation, migration, growth inhibition, and apoptosis. Gain of function alterations, through their overexpression, deletions, or point mutations in their kinase domains, have been implicated in various cancers. These receptors are targets of many small molecule inhibitors and monoclonal antibodies used in cancer therapy. The EGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270648 [Multi-domain]  Cd Length: 279  Bit Score: 65.90  E-value: 4.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  21 VFRELEILQEIEHVFLVNLwYSFQDEEDMFMVVDLLLGGDLRYHLQQNvqfsEDTVR----LYICE-MALALDYLRSQHI 95
Cdd:cd05057   56 ILDEAYVMASVDHPHLVRL-LGICLSSQVQLITQLMPLGCLLDYVRNH----RDNIGsqllLNWCVqIAKGMSYLEEKRL 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  96 IHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTK---PYMAPEIFHSFVnggtgYSFEVDWWSVGVMAYELL 172
Cdd:cd05057  131 VHRDLAARNVLVKTPNHVKITDFGLAKLLDVDEKEYHAEGGKvpiKWMALESIQYRI-----YTHKSDVWSYGVTVWELM 205

                 ....*...
gi 247269852 173 R-GWRPYD 179
Cdd:cd05057  206 TfGAKPYE 213
STKc_TDY_MAPK cd07859
Catalytic domain of the Serine/Threonine Kinases, Plant TDY Mitogen-Activated Protein Kinases; ...
21-174 4.48e-12

Catalytic domain of the Serine/Threonine Kinases, Plant TDY Mitogen-Activated Protein Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Plant MAPKs are typed based on the conserved phosphorylation motif present in the activation loop, TEY and TDY. This subfamily represents the TDY subtype and is composed of Group D plant MAPKs including Arabidopsis thaliana MPK18 (AtMPK18), Oryza sativa Blast- and Wound-induced MAPK1 (OsBWMK1), OsWJUMK1 (Wound- and JA-Uninducible MAPK1), Zea mays MPK6, and the Medicago sativa TDY1 gene product. OsBWMK1 enhances resistance to pathogenic infections. It mediates stress-activated defense responses by activating a transcription factor that affects the expression of stress-related genes. AtMPK18 is involved in microtubule-related functions. In plants, MAPKs are associated with physiological, developmental, hormonal, and stress responses. Some plants show numerous gene duplications of MAPKs; Arabidopsis thaliana harbors at least 20 MAPKs, named AtMPK1-20 while Oryza sativa contains at least 17 MAPKs. Arabidopsis thaliana contains more TEY-type MAPKs than TDY-type, whereas the reverse is true for Oryza sativa. The TDY MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143364 [Multi-domain]  Cd Length: 338  Bit Score: 66.34  E-value: 4.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  21 VFRELEILQ--------EIEHVFLVNLWYSFQDeedmFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRS 92
Cdd:cd07859   46 ILREIKLLRllrhpdivEIKHIMLPPSRREFKD----IYVVFELMESDLHQVIKANDDLTPEHHQFFLYQLLRALKYIHT 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILLDEQGHAHLTDFNIATI-IKDGERA---TALAGTKPYMAPEIFHSFVnggTGYSFEVDWWSVGVMA 168
Cdd:cd07859  122 ANVFHRDLKPKNILANADCKLKICDFGLARVaFNDTPTAifwTDYVATRWYRAPELCGSFF---SKYTPAIDIWSIGCIF 198

                 ....*.
gi 247269852 169 YELLRG 174
Cdd:cd07859  199 AEVLTG 204
PTKc_Fer cd05085
Catalytic domain of the Protein Tyrosine Kinase, Fer; Protein Tyrosine Kinase (PTK) family; ...
22-228 4.71e-12

Catalytic domain of the Protein Tyrosine Kinase, Fer; Protein Tyrosine Kinase (PTK) family; Fer kinase; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fer kinase is a member of the Fes subfamily of proteins which are cytoplasmic (or nonreceptor) tyr kinases containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. Fer kinase is expressed in a wide variety of tissues, and is found to reside in both the cytoplasm and the nucleus. It plays important roles in neuronal polarization and neurite development, cytoskeletal reorganization, cell migration, growth factor signaling, and the regulation of cell-cell interactions mediated by adherens junctions and focal adhesions. Fer kinase also regulates cell cycle progression in malignant cells.


Pssm-ID: 270668 [Multi-domain]  Cd Length: 251  Bit Score: 65.41  E-value: 4.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  22 FRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL---------QQNVQFSEDTvrlyicemALALDYLRS 92
Cdd:cd05085   41 LSEARILKQYDHPNIVKLIGVCTQRQPIYIVMELVPGGDFLSFLrkkkdelktKQLVKFSLDA--------AAGMAYLES 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKP--YMAPEIfhsfVNGGTgYSFEVDWWSVGVMAYE 170
Cdd:cd05085  113 KNCIHRDLAARNCLVGENNALKISDFGMSRQEDDGVYSSSGLKQIPikWTAPEA----LNYGR-YSSESDVWSFGILLWE 187
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 247269852 171 LLR-GWRPY-DIHSSNAVESLVQLFSTVSVQYVPtwsKEMVALLRKLLTVNPEHR--FSSLQ 228
Cdd:cd05085  188 TFSlGVCPYpGMTNQQAREQVEKGYRMSAPQRCP---EDIYKIMQRCWDYNPENRpkFSELQ 246
PTKc_Jak2_rpt2 cd14205
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2; PTKs catalyze the ...
7-172 5.16e-12

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak2 is widely expressed in many tissues and is essential for the signaling of hormone-like cytokines such as growth hormone, erythropoietin, thrombopoietin, and prolactin, as well as some IFNs and cytokines that signal through the IL-3 and gp130 receptors. Disruption of Jak2 in mice results in an embryonic lethal phenotype with multiple defects including erythropoietic and cardiac abnormalities. It is the only Jak gene that results in a lethal phenotype when disrupted in mice. A mutation in the pseudokinase domain of Jak2, V617F, is present in many myeloproliferative diseases, including almost all patients with polycythemia vera, and 50% of patients with essential thrombocytosis and myelofibrosis. Jak2 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271107 [Multi-domain]  Cd Length: 284  Bit Score: 65.81  E-value: 5.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   7 MNKQQCIERDEVRNVFRELEILQEIEHVFLVN---LWYSfQDEEDMFMVVDLLLGGDLRYHLQQNVQ-FSEDTVRLYICE 82
Cdd:cd14205   38 VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKykgVCYS-AGRRNLRLIMEYLPYGSLRDYLQKHKErIDHIKLLQYTSQ 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATII-KDGERATAL-AGTKP--YMAPEIFHSfvnggTGYSFE 158
Cdd:cd14205  117 ICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLpQDKEYYKVKePGESPifWYAPESLTE-----SKFSVA 191
                        170
                 ....*....|....
gi 247269852 159 VDWWSVGVMAYELL 172
Cdd:cd14205  192 SDVWSFGVVLYELF 205
PTKc_Srm_Brk cd05148
Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal ...
23-229 5.31e-12

Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (Srm) and Breast tumor kinase (Brk); PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Srm and Brk (also called protein tyrosine kinase 6) are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Brk has been found to be overexpressed in a majority of breast tumors. Src kinases in general contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr; they are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Srm and Brk however, lack the N-terminal myristylation sites. Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. The Srm/Brk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133248 [Multi-domain]  Cd Length: 261  Bit Score: 65.15  E-value: 5.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQ----QNVQFSEdtvRLYI-CEMALALDYLRSQHIIH 97
Cdd:cd05148   51 KEVQALKRLRHKHLISLFAVCSVGEPVYIITELMEKGSLLAFLRspegQVLPVAS---LIDMaCQVAEGMAYLEEQNSIH 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  98 RDVKPDNILLDEQGHAHLTDFNIATIIKDGERATalAGTK-PY--MAPEIfhsfVNGGTgYSFEVDWWSVGVMAYELL-R 173
Cdd:cd05148  128 RDLAARNILVGEDLVCKVADFGLARLIKEDVYLS--SDKKiPYkwTAPEA----ASHGT-FSTKSDVWSFGILLYEMFtY 200
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 174 GWRPYDihSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHR--FSSLQD 229
Cdd:cd05148  201 GQVPYP--GMNNHEVYDQITAGYRMPCPAKCPQEIYKIMLECWAAEPEDRpsFKALRE 256
PTKc_Frk_like cd05068
Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
23-178 6.35e-12

Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Frk and Srk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Frk, also known as Rak, is specifically expressed in liver, lung, kidney, intestine, mammary glands, and the islets of Langerhans. Rodent homologs were previously referred to as GTK (gastrointestinal tyr kinase), BSK (beta-cell Src-like kinase), or IYK (intestinal tyr kinase). Studies in mice reveal that Frk is not essential for viability. It plays a role in the signaling that leads to cytokine-induced beta-cell death in Type I diabetes. It also regulates beta-cell number during embryogenesis and early in life. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Frk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270653 [Multi-domain]  Cd Length: 267  Bit Score: 65.12  E-value: 6.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQnvqfseDTVRLYI-------CEMALALDYLRSQHI 95
Cdd:cd05068   52 REAQIMKKLRHPKLIQLYAVCTLEEPIYIITELMKHGSLLEYLQG------KGRSLQLpqlidmaAQVASGMAYLESQNY 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  96 IHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTK---PYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELL 172
Cdd:cd05068  126 IHRDLAARNVLVGENNICKVADFGLARVIKVEDEYEAREGAKfpiKWTAPEAANY-----NRFSIKSDVWSFGILLTEIV 200

                 ....*..
gi 247269852 173 R-GWRPY 178
Cdd:cd05068  201 TyGRIPY 207
PK_eIF2AK_GCN2_rpt1 cd14012
Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or ...
8-228 6.53e-12

Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. eIF-2 phosphorylation is induced in response to cellular stresses including virus infection, heat shock, nutrient deficiency, and the accummulation of unfolded proteins, among others. There are four distinct kinases that phosphorylate eIF-2 and control protein synthesis under different stress conditions: GCN2, protein kinase regulated by RNA (PKR), heme-regulated inhibitor kinase (HRI), and PKR-like endoplasmic reticulum kinase (PERK). GCN2 is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kappaB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. The degenerate pseudokinase domain of GCN2 may function as a regulatory domain. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270914 [Multi-domain]  Cd Length: 254  Bit Score: 65.07  E-value: 6.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   8 NKQQCIE--RDEVRNVFRELEILQEIEHVFLVNLwYSFQDEED-------MFMVVDLLLGGDLRYHLQQNVQFSEDTVRL 78
Cdd:cd14012   30 QEYFKTSngKKQIQLLEKELESLKKLRHPNLVSY-LAFSIERRgrsdgwkVYLLTEYAPGGSLSELLDSVGSVPLDTARR 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGH---AHLTDFNIATIIKDGERATALAGTKP--YMAPEIfhsfVNGGT 153
Cdd:cd14012  109 WTLQLLEALEYLHRNGVVHKSLHAGNVLLDRDAGtgiVKLTDYSLGKTLLDMCSRGSLDEFKQtyWLPPEL----AQGSK 184
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 154 GYSFEVDWWSVGVMAYELLRG---WRPYdiHSSNAVESLVQLfstvsvqyvptwSKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd14012  185 SPTRKTDVWDLGLLFLQMLFGldvLEKY--TSPNPVLVSLDL------------SASLQDFLSKCLSLDPKKRPTALE 248
STKc_MLK1 cd14145
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1; STKs catalyze the ...
18-233 6.72e-12

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK1 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK) and is also called MAP3K9. MAP3Ks phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Little is known about the specific function of MLK1. It is capable of activating the c-Jun N-terminal kinase pathway. Mice lacking both MLK1 and MLK2 are viable, fertile, and have normal life spans. There could be redundancy in the function of MLKs. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271047 [Multi-domain]  Cd Length: 270  Bit Score: 65.06  E-value: 6.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  18 VRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNvQFSEDTVRLYICEMALALDYLRSQHI-- 95
Cdd:cd14145   49 IENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGK-RIPPDILVNWAVQIARGMNYLHCEAIvp 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  96 -IHRDVKPDNILLDEQGH--------AHLTDFNIAtiiKDGERATAL--AGTKPYMAPEIFHSfvnggTGYSFEVDWWSV 164
Cdd:cd14145  128 vIHRDLKSSNILILEKVEngdlsnkiLKITDFGLA---REWHRTTKMsaAGTYAWMAPEVIRS-----SMFSKGSDVWSY 199
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 247269852 165 GVMAYELLRGWRPYDIHSSNAVESLVQLfSTVSVQYVPTWSKEMVALLRKLLTVNPEHR--FSSLQDMQTA 233
Cdd:cd14145  200 GVLLWELLTGEVPFRGIDGLAVAYGVAM-NKLSLPIPSTCPEPFARLMEDCWNPDPHSRppFTNILDQLTA 269
PTKc_Jak_rpt2 cd05038
Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily ...
23-172 7.51e-12

Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily is composed of Jak1, Jak2, Jak3, TYK2, and similar proteins. They are PTKs, catalyzing the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jaks are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase catalytic domain. Most Jaks are expressed in a wide variety of tissues, except for Jak3, which is expressed only in hematopoietic cells. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). Jaks are also involved in regulating the surface expression of some cytokine receptors. The Jak-STAT pathway is involved in many biological processes including hematopoiesis, immunoregulation, host defense, fertility, lactation, growth, and embryogenesis. The Jak subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270634 [Multi-domain]  Cd Length: 284  Bit Score: 65.09  E-value: 7.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNL--WYSFQDEEDMFMVVDLLLGGDLRYHLQQN---------VQFSEDtvrlyICEmalALDYLR 91
Cdd:cd05038   55 REIEILRTLDHEYIVKYkgVCESPGRRSLRLIMEYLPSGSLRDYLQRHrdqidlkrlLLFASQ-----ICK---GMEYLG 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  92 SQHIIHRDVKPDNILLDEQGHAHLTDFNIATII---KDGERATALaGTKP--YMAPEIFHSfvnggTGYSFEVDWWSVGV 166
Cdd:cd05038  127 SQRYIHRDLAARNILVESEDLVKISDFGLAKVLpedKEYYYVKEP-GESPifWYAPECLRE-----SRFSSASDVWSFGV 200

                 ....*.
gi 247269852 167 MAYELL 172
Cdd:cd05038  201 TLYELF 206
PTKc_Fes cd05084
Catalytic domain of the Protein Tyrosine Kinase, Fes; PTKs catalyze the transfer of the ...
17-191 7.60e-12

Catalytic domain of the Protein Tyrosine Kinase, Fes; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fes (or Fps) is a cytoplasmic (or nonreceptor) PTK containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. The genes for Fes (feline sarcoma) and Fps (Fujinami poultry sarcoma) were first isolated from tumor-causing retroviruses. The viral oncogenes encode chimeric Fes proteins consisting of Gag sequences at the N-termini, resulting in unregulated PTK activity. Fes kinase is expressed in myeloid, vascular endothelial, epithelial, and neuronal cells. It plays important roles in cell growth and differentiation, angiogenesis, inflammation and immunity, and cytoskeletal regulation. A recent study implicates Fes kinase as a tumor suppressor in colorectal cancer. The Fes subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270667 [Multi-domain]  Cd Length: 252  Bit Score: 64.95  E-value: 7.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  17 EVRNVF-RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALA-LDYLRSQH 94
Cdd:cd05084   36 DLKAKFlQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGPRLKVKELIRMVENAAAgMEYLESKH 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  95 IIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERAtALAGTK----PYMAPEIfhsfVNGGTgYSFEVDWWSVGVMAYE 170
Cdd:cd05084  116 CIHRDLAARNCLVTEKNVLKISDFGMSREEEDGVYA-ATGGMKqipvKWTAPEA----LNYGR-YSSESDVWSFGILLWE 189
                        170       180
                 ....*....|....*....|..
gi 247269852 171 LL-RGWRPYDIHSSNAVESLVQ 191
Cdd:cd05084  190 TFsLGAVPYANLSNQQTREAVE 211
STKc_MLK cd14061
Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases; STKs catalyze the ...
82-178 7.69e-12

Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLKs act as mitogen-activated protein kinase kinase kinases (MAP3Ks, MKKKs, MAPKKKs), which phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Mammals have four MLKs (MLK1-4), mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270963 [Multi-domain]  Cd Length: 258  Bit Score: 64.72  E-value: 7.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQH---IIHRDVKPDNILLDEQ-GHAHL-------TDFNIATIIKDGERATAlAGTKPYMAPEIFHSFVn 150
Cdd:cd14061  100 QIARGMNYLHNEApvpIIHRDLKSSNILILEAiENEDLenktlkiTDFGLAREWHKTTRMSA-AGTYAWMAPEVIKSST- 177
                         90       100
                 ....*....|....*....|....*...
gi 247269852 151 ggtgYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd14061  178 ----FSKASDVWSYGVLLWELLTGEVPY 201
PTKc_Lck_Blk cd05067
Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk; PTKs ...
24-230 8.72e-12

Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Lck and Blk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lck is expressed in T-cells and natural killer cells. It plays a critical role in T-cell maturation, activation, and T-cell receptor (TCR) signaling. Lck phosphorylates ITAM (immunoreceptor tyr activation motif) sequences on several subunits of TCRs, leading to the activation of different second messenger cascades. Phosphorylated ITAMs serve as binding sites for other signaling factor such as Syk and ZAP-70, leading to their activation and propagation of downstream events. In addition, Lck regulates drug-induced apoptosis by interfering with the mitochondrial death pathway. The apototic role of Lck is independent of its primary function in T-cell signaling. Blk is expressed specifically in B-cells. It is involved in pre-BCR (B-cell receptor) signaling. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Lck/Blk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270652 [Multi-domain]  Cd Length: 264  Bit Score: 64.91  E-value: 8.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  24 ELEILQEIEHVFLVNLwYSFQDEEDMFMVVDLLLGGDLRYHLQqnvqfSEDTVRLYI-------CEMALALDYLRSQHII 96
Cdd:cd05067   52 EANLMKQLQHQRLVRL-YAVVTQEPIYIITEYMENGSLVDFLK-----TPSGIKLTInklldmaAQIAEGMAFIEERNYI 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  97 HRDVKPDNILLDEQGHAHLTDFNIATIIKDGERaTALAGTK---PYMAPEIfhsfVNGGTgYSFEVDWWSVGVMAYELLR 173
Cdd:cd05067  126 HRDLRAANILVSDTLSCKIADFGLARLIEDNEY-TAREGAKfpiKWTAPEA----INYGT-FTIKSDVWSFGILLTEIVT 199
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 247269852 174 GWR-PY-DIHSSNAVESLVQLFSTVSVQYVPtwsKEMVALLRKLLTVNPEHR--FSSLQDM 230
Cdd:cd05067  200 HGRiPYpGMTNPEVIQNLERGYRMPRPDNCP---EELYQLMRLCWKERPEDRptFEYLRSV 257
STKc_JNK3 cd07874
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 3; STKs catalyze the ...
19-173 1.36e-11

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK3 is expressed primarily in the brain, and to a lesser extent in the heart and testis. Mice deficient in JNK3 are protected against kainic acid-induced seizures, stroke, sciatic axotomy neural death, and neuronal death due to NGF deprivation, oxidative stress, or exposure to beta-amyloid peptide. This suggests that JNK3 may play roles in the pathogenesis of these diseases. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143379 [Multi-domain]  Cd Length: 355  Bit Score: 65.11  E-value: 1.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  19 RNVFRELEILQEIEHVFLVNLWYSF------QDEEDMFMVVDLLlggdlRYHLQQNVQFSEDTVRL--YICEMALALDYL 90
Cdd:cd07874   61 KRAYRELVLMKCVNHKNIISLLNVFtpqkslEEFQDVYLVMELM-----DANLCQVIQMELDHERMsyLLYQMLCGIKHL 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  91 RSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYE 170
Cdd:cd07874  136 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL-----GMGYKENVDIWSVGCIMGE 210

                 ...
gi 247269852 171 LLR 173
Cdd:cd07874  211 MVR 213
PTKc_Src_like cd05034
Catalytic domain of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of ...
23-178 1.65e-11

Catalytic domain of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Src subfamily members include Src, Lck, Hck, Blk, Lyn, Fgr, Fyn, Yrk, and Yes. Src (or c-Src) proteins are cytoplasmic (or non-receptor) PTKs which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. Src kinases are overexpressed in a variety of human cancers, making them attractive targets for therapy. They are also implicated in acute inflammatory responses and osteoclast function. Src, Fyn, Yes, and Yrk are widely expressed, while Blk, Lck, Hck, Fgr, and Lyn show a limited expression pattern. The Src-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270630 [Multi-domain]  Cd Length: 248  Bit Score: 63.84  E-value: 1.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDL---------RY-HLQQNVQFSedtvrlyiCEMALALDYLRS 92
Cdd:cd05034   39 QEAQIMKKLRHDKLVQLYAVCSDEEPIYIVTELMSKGSLldylrtgegRAlRLPQLIDMA--------AQIASGMAYLES 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERaTALAGTK-P--YMAPE-IFHSfvnggtGYSFEVDWWSVGVMA 168
Cdd:cd05034  111 RNYIHRDLAARNILVGENNVCKVADFGLARLIEDDEY-TAREGAKfPikWTAPEaALYG------RFTIKSDVWSFGILL 183
                        170
                 ....*....|.
gi 247269852 169 YELL-RGWRPY 178
Cdd:cd05034  184 YEIVtYGRVPY 194
PTKc_EGFR cd05108
Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor; PTKs ...
82-223 1.77e-11

Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EGFR (HER1, ErbB1) is a receptor PTK (RTK) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Ligands for EGFR include EGF, heparin binding EGF-like growth factor (HBEGF), epiregulin, amphiregulin, TGFalpha, and betacellulin. Upon ligand binding, EGFR can form homo- or heterodimers with other EGFR subfamily members. The EGFR signaling pathway is one of the most important pathways regulating cell proliferation, differentiation, survival, and growth. Overexpression and mutation in the kinase domain of EGFR have been implicated in the development and progression of a variety of cancers. A number of monoclonal antibodies and small molecule inhibitors have been developed that target EGFR, including the antibodies Cetuximab and Panitumumab, which are used in combination with other therapies for the treatment of colorectal cancer and non-small cell lung carcinoma (NSCLC). The small molecule inhibitors Gefitinib (Iressa) and Erlotinib (Tarceva), already used for NSCLC, are undergoing clinical trials for other types of cancer including gastrointestinal, breast, head and neck, and bladder. The EGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270683 [Multi-domain]  Cd Length: 313  Bit Score: 64.27  E-value: 1.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTK---PYMAPE-IFHSFvnggtgYSF 157
Cdd:cd05108  117 QIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKvpiKWMALEsILHRI------YTH 190
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 158 EVDWWSVGVMAYELLR-GWRPYDIHSSNAVESLVQlfSTVSVQYVPTWSKEMVALLRKLLTVNPEHR 223
Cdd:cd05108  191 QSDVWSYGVTVWELMTfGSKPYDGIPASEISSILE--KGERLPQPPICTIDVYMIMVKCWMIDADSR 255
STKc_MAPK4_6 cd07854
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also ...
18-226 3.98e-11

Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK4 (also called ERK4 or p63MAPK) and MAPK6 (also called ERK3 or p97MAPK) are atypical MAPKs that are not regulated by MAPK kinases. MAPK6 is expressed ubiquitously with highest amounts in brain and skeletal muscle. It may be involved in the control of cell differentiation by negatively regulating cell cycle progression in certain conditions. It may also play a role in glucose-induced insulin secretion. MAPK6 and MAPK4 cooperate to regulate the activity of MAPK-activated protein kinase 5 (MK5), leading to its relocation to the cytoplasm and exclusion from the nucleus. The MAPK6/MK5 and MAPK4/MK5 pathways may play critical roles in embryonic and post-natal development. MAPKs are important mediators of cellular responses to extracellular signals. The MAPK4/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143359 [Multi-domain]  Cd Length: 342  Bit Score: 63.64  E-value: 3.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  18 VRNVFRELEILQEIEHVFLVNLW-------------YSFQDEEDMFMVVDLLLGGDLRYHLQQNvQFSEDTVRLYICEMA 84
Cdd:cd07854   46 VKHALREIKIIRRLDHDNIVKVYevlgpsgsdltedVGSLTELNSVYIVQEYMETDLANVLEQG-PLSEEHARLFMYQLL 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  85 LALDYLRSQHIIHRDVKPDNILLD-EQGHAHLTDFNIATIIK-----DGERATALAgTKPYMAPEIFHSFVNggtgYSFE 158
Cdd:cd07854  125 RGLKYIHSANVLHRDLKPANVFINtEDLVLKIGDFGLARIVDphyshKGYLSEGLV-TKWYRSPRLLLSPNN----YTKA 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 159 VDWWSVGVMAYELLRGwRPYdIHSSNAVESLVQLFSTVSV-----------------------------QYVPTWSKEMV 209
Cdd:cd07854  200 IDMWAAGCIFAEMLTG-KPL-FAGAHELEQMQLILESVPVvreedrnellnvipsfvrndggeprrplrDLLPGVNPEAL 277
                        250
                 ....*....|....*..
gi 247269852 210 ALLRKLLTVNPEHRFSS 226
Cdd:cd07854  278 DFLEQILTFNPMDRLTA 294
STKc_PCTAIRE2 cd07872
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase; STKs catalyze the transfer ...
23-177 4.02e-11

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-2 is specifically expressed in neurons in the central nervous system, mainly in terminally differentiated neurons. It associates with Trap (Tudor repeat associator with PCTAIRE-2) and could play a role in regulating mitochondrial function in neurons. PCTAIRE-2 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143377 [Multi-domain]  Cd Length: 309  Bit Score: 63.47  E-value: 4.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQ--NVqFSEDTVRLYICEMALALDYLRSQHIIHRDV 100
Cdd:cd07872   53 REVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYL-DKDLKQYMDDcgNI-MSMHNVKIFLYQILRGLAYCHRRKVLHRDL 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 101 KPDNILLDEQGHAHLTDFNIAtiikdgeRATALAG--------TKPYMAPEIFHsfvnGGTGYSFEVDWWSVGVMAYELL 172
Cdd:cd07872  131 KPQNLLINERGELKLADFGLA-------RAKSVPTktysnevvTLWYRPPDVLL----GSSEYSTQIDMWGVGCIFFEMA 199

                 ....*
gi 247269852 173 RGwRP 177
Cdd:cd07872  200 SG-RP 203
STKc_CDK8_like cd07842
Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases; STKs ...
23-231 4.14e-11

Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK8, CDC2L6, and similar proteins. CDK8 functions as a negative or positive regulator of transcription, depending on the scenario. Together with its regulator, cyclin C, it reversibly associates with the multi-subunit core Mediator complex, a cofactor that is involved in regulating RNA polymerase II-dependent transcription. CDC2L6 also associates with Mediator in complexes lacking CDK8. In VP16-dependent transcriptional activation, CDK8 and CDC2L6 exerts opposing effects by positive and negative regulation, respectively, in similar conditions. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK8-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270834 [Multi-domain]  Cd Length: 316  Bit Score: 63.46  E-value: 4.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDM--FMVVDLL---LGGDLRYHLQ-QNVQFSEDTVRLYICEMALALDYLRSQHII 96
Cdd:cd07842   51 REIALLRELKHENVVSLVEVFLEHADKsvYLLFDYAehdLWQIIKFHRQaKRVSIPPSMVKSLLWQILNGIHYLHSNWVL 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  97 HRDVKPDNILL----DEQGHAHLTDFNIATIIKDGERATAlAGTKP-----YMAPEIFHsfvnGGTGYSFEVDWWSVGVM 167
Cdd:cd07842  131 HRDLKPANILVmgegPERGVVKIGDLGLARLFNAPLKPLA-DLDPVvvtiwYRAPELLL----GARHYTKAIDIWAIGCI 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 168 AYELL------RGwRPYDIHSSN-----AVESLVQLFSTVSVQ------YVPTWSKEMVA-------------------- 210
Cdd:cd07842  206 FAELLtlepifKG-REAKIKKSNpfqrdQLERIFEVLGTPTEKdwpdikKMPEYDTLKSDtkastypnsllakwmhkhkk 284
                        250       260
                 ....*....|....*....|....*...
gi 247269852 211 -------LLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd07842  285 pdsqgfdLLRKLLEYDPTKRITAEEALE 312
STKc_JNK2 cd07876
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 2; STKs catalyze the ...
19-174 4.99e-11

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK2 is expressed in every cell and tissue type. It is specifically translocated to the mitochondria during dopaminergic cell death. Specific substrates include the microtubule-associated proteins DCX and Tau, as well as TIF-IA which is involved in ribosomal RNA synthesis regulation. Mice deficient in Jnk2 show protection against arthritis, type 1 diabetes, atherosclerosis, abdominal aortic aneurysm, cardiac cell death, TNF-induced liver damage, and tumor growth, indicating that JNK2 may play roles in the pathogenesis of these diseases. Initially it was thought that JNK1 and JNK2 were functionally redundant as mice deficient in either genes could survive but disruption of both genes resulted in lethality. However, recent studies have shown that JNK1 and JNK2 perform distinct functions through specific binding partners and substrates. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143381 [Multi-domain]  Cd Length: 359  Bit Score: 63.51  E-value: 4.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  19 RNVFRELEILQEIEH---VFLVNLWY---SFQDEEDMFMVVDLLlggdlRYHLQQNVQFSEDTVRL--YICEMALALDYL 90
Cdd:cd07876   65 KRAYRELVLLKCVNHkniISLLNVFTpqkSLEEFQDVYLVMELM-----DANLCQVIHMELDHERMsyLLYQMLCGIKHL 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  91 RSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYE 170
Cdd:cd07876  140 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVIL-----GMGYKENVDIWSVGCIMGE 214

                 ....
gi 247269852 171 LLRG 174
Cdd:cd07876  215 LVKG 218
PKc_LIMK_like_unk cd14156
Catalytic domain of an unknown subfamily of LIM domain kinase-like protein kinases; PKs ...
21-172 5.48e-11

Catalytic domain of an unknown subfamily of LIM domain kinase-like protein kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. This group is composed of uncharacterized proteins with similarity to LIMK and Testicular or testis-specific protein kinase (TESK). LIMKs are characterized as serine/threonine kinases (STKs) while TESKs are dual-specificity protein kinases. Both LIMK and TESK phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They are implicated in many cellular functions including cell spreading, motility, morphogenesis, meiosis, mitosis, and spermatogenesis. The LIMK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271058 [Multi-domain]  Cd Length: 256  Bit Score: 62.15  E-value: 5.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  21 VFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL-QQNVQFS-EDTVRLyICEMALALDYLRSQHIIHR 98
Cdd:cd14156   35 IVREISLLQKLSHPNIVRYLGICVKDEKLHPILEYVSGGCLEELLaREELPLSwREKVEL-ACDISRGMVYLHSKNIYHR 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  99 DVKPDNILLDEQGH---AHLTDFNIATII-----KDGERATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYE 170
Cdd:cd14156  114 DLNSKNCLIRVTPRgreAVVTDFGLAREVgempaNDPERKLSLVGSAFWMAPEMLR-----GEPYDRKVDVFSFGIVLCE 188

                 ..
gi 247269852 171 LL 172
Cdd:cd14156  189 IL 190
STKc_MLK2 cd14148
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2; STKs catalyze the ...
82-178 5.50e-11

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK2 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK) and is also called MAP3K10. MAP3Ks phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MLK2 is abundant in brain, skeletal muscle, and testis. It functions upstream of the MAPK, c-Jun N-terminal kinase. It binds hippocalcin, a calcium-sensor protein that protects neurons against calcium-induced cell death. Both MLK2 and hippocalcin may be associated with the pathogenesis of Parkinson's disease. MLK2 also binds to normal huntingtin (Htt), which is important in neuronal transcription, development, and survival. MLK2 does not bind to the polyglutamine-expanded Htt, which is implicated in the pathogeneis of Huntington's disease, leading to neuronal toxicity. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 271050 [Multi-domain]  Cd Length: 258  Bit Score: 62.31  E-value: 5.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQH---IIHRDVKPDNILLDEQGHAH--------LTDFNIAtiiKDGERATAL--AGTKPYMAPEIF-HS 147
Cdd:cd14148  100 QIARGMNYLHNEAivpIIHRDLKSSNILILEPIENDdlsgktlkITDFGLA---REWHKTTKMsaAGTYAWMAPEVIrLS 176
                         90       100       110
                 ....*....|....*....|....*....|.
gi 247269852 148 FvnggtgYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd14148  177 L------FSKSSDVWSFGVLLWELLTGEVPY 201
STKc_NAK_like cd14037
Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases; STKs catalyze ...
80-223 6.12e-11

Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Drosophila melanogaster NAK, human BMP-2-inducible protein kinase (BMP2K or BIKe) and similar vertebrate proteins, as well as the Saccharomyces cerevisiae proteins Prk1, Actin-regulating kinase 1 (Ark1), and Akl1. NAK was the first characterized member of this subfamily. It plays a role in asymmetric cell division through its association with Numb. It also regulates the localization of Dlg, a protein essential for septate junction formation. BMP2K contains a nuclear localization signal and a kinase domain that is capable of phosphorylating itself and myelin basic protein. The expression of the BMP2K gene is increase during BMP-2-induced osteoblast differentiation. It may function to control the rate of differentiation. Prk1, Ark1, and Akl1 comprise a subfamily of yeast proteins that are important regulators of the actin cytoskeleton and endocytosis. They share an N-terminal kinase domain but no significant homology in other regions of their sequences. The NAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270939 [Multi-domain]  Cd Length: 277  Bit Score: 62.30  E-value: 6.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLrSQHIIHRDVKPDNILLDEQGHAHLTDFNIATII------KDG--------ERATalagTKPYMAPEIF 145
Cdd:cd14037  117 VCEAVAAMHYL-KPPLIHRDLKVENVLISDSGNYKLCDFGSATTKilppqtKQGvtyveediKKYT----TLQYRAPEMI 191
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 146 HsfVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESlvqlfSTVSVQYVPTWSKEMVALLRKLLTVNPEHR 223
Cdd:cd14037  192 D--LYRGKPITEKSDIWALGCLLYKLCFYTTPFEESGQLAILN-----GNFTFPDNSRYSKRLHKLIRYMLEEDPEKR 262
PKc_CLK cd14134
Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases; Dual-specificity ...
18-181 6.83e-11

Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. CLKs are involved in the phosphorylation and regulation of serine/arginine-rich (SR) proteins, which play a crucial role in pre-mRNA splicing by directing splice site selection. SR proteins are phosphorylated first by SR protein kinases (SRPKs) at the N-terminus, which leads to its assembly into nuclear speckles where splicing factors are stored. CLKs phosphorylate the C-terminal part of SR proteins, causing the nuclear speckles to dissolve and splicing factors to be recruited at sites of active transcription. Based on a conserved "EHLAMMERILG" signature motif which may be crucial for substrate specificity, CLKs are also referred to as LAMMER kinases. CLKs autophosphorylate at tyrosine residues and phosphorylate their substrates exclusively on S/T residues. In Drosophila, the CLK homolog DOA (Darkener of apricot) is essential for embryogenesis and its mutation leads to defects in sexual differentiation, eye formation, and neuronal development. In fission yeast, the CLK homolog Lkh1 is a negative regulator of filamentous growth and asexual flocculation, and is also involved in oxidative stress response. Vertebrates contain mutliple CLK proteins and mammals have four (CLK1-4). The CLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271036 [Multi-domain]  Cd Length: 332  Bit Score: 62.58  E-value: 6.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  18 VRNVFR-------ELEILQEIE--------HVflVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQN--VQFSEDTVRLYI 80
Cdd:cd14134   45 IRNVEKyreaakiEIDVLETLAekdpngksHC--VQLRDWFDYRGHMCIVFELL-GPSLYDFLKKNnyGPFPLEHVQHIA 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLD-------------------EQGHAHLTDFNIATIikDGERATALAGTKPYMA 141
Cdd:cd14134  122 KQLLEAVAFLHDLKLTHTDLKPENILLVdsdyvkvynpkkkrqirvpKSTDIKLIDFGSATF--DDEYHSSIVSTRHYRA 199
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 247269852 142 PEIFHsfvngGTGYSFEVDWWSVGVMAYELLRGWRPYDIH 181
Cdd:cd14134  200 PEVIL-----GLGWSYPCDVWSIGCILVELYTGELLFQTH 234
PTKc_FGFR2 cd05101
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2; PTKs ...
7-223 7.05e-11

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. There are many splice variants of FGFR2 which show differential expression and binding to FGF ligands. Disruption of either FGFR2 or FGFR2b is lethal in mice, due to defects in the placenta or severe impairment of tissue development including lung, limb, and thyroid, respectively. Disruption of FGFR2c in mice results in defective bone and skull development. Genetic alterations of FGFR2 are associated with many human skeletal disorders including Apert syndrome, Crouzon syndrome, Jackson-Weiss syndrome, and Pfeiffer syndrome. FGFR2 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270679 [Multi-domain]  Cd Length: 313  Bit Score: 62.73  E-value: 7.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   7 MNKQQCIERDeVRNVFRELEILQEI-EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ----NVQFSEDTVR---- 77
Cdd:cd05101   63 MLKDDATEKD-LSDLVSEMEMMKMIgKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRArrppGMEYSYDINRvpee 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  78 ------LYIC--EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIK--DGERATAlAGTKP--YMAPEIF 145
Cdd:cd05101  142 qmtfkdLVSCtyQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINniDYYKKTT-NGRLPvkWMAPEAL 220
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 146 HSFVnggtgYSFEVDWWSVGVMAYELLR-GWRPYdihSSNAVESLVQLFSTVSVQYVP-TWSKEMVALLRKLLTVNPEHR 223
Cdd:cd05101  221 FDRV-----YTHQSDVWSFGVLMWEIFTlGGSPY---PGIPVEELFKLLKEGHRMDKPaNCTNELYMMMRDCWHAVPSQR 292
STKc_IRAK4 cd14158
Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4; ...
3-185 7.65e-11

Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain, and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK4 plays a critical role in NFkB activation by its interaction with MyD88, which acts as a scaffold that enables IRAK4 to phosphorylate and activate IRAK1 and/or IRAK2. It also plays an important role in type I IFN production induced by TLR7/8/9. The IRAK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271060 [Multi-domain]  Cd Length: 288  Bit Score: 62.13  E-value: 7.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNVF-RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQqnvqFSEDT------ 75
Cdd:cd14158   42 AVKKLAAMVDISTEDLTKQFeQEIQVMAKCQHENLVELLGYSCDGPQLCLVYTYMPNGSLLDRLA----CLNDTpplswh 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  76 VRLYICE-MALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAtiikdgeRATA----------LAGTKPYMAPEI 144
Cdd:cd14158  118 MRCKIAQgTANGINYLHENNHIHRDIKSANILLDETFVPKISDFGLA-------RASEkfsqtimterIVGTTAYMAPEA 190
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 247269852 145 FHSFVnggtgySFEVDWWSVGVMAYELLRGWRPYDIHSSNA 185
Cdd:cd14158  191 LRGEI------TPKSDIFSFGVVLLEIITGLPPVDENRDPQ 225
STKc_JNK1 cd07875
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 1; STKs catalyze the ...
19-174 1.06e-10

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK1 is expressed in every cell and tissue type. It specifically binds with JAMP (JNK1-associated membrane protein), which regulates the duration of JNK1 activity in response to stimuli. Specific JNK1 substrates include Itch and SG10, which are implicated in Th2 responses and airway inflammation, and microtubule dynamics and axodendritic length, respectively. Mice deficient in JNK1 are protected against arthritis, obesity, type 2 diabetes, cardiac cell death, and non-alcoholic liver disease, suggesting that JNK1 may play roles in the pathogenesis of these diseases. Initially, it was thought that JNK1 and JNK2 were functionally redundant as mice deficient in either genes could survive but disruption of both genes resulted in lethality. However, recent studies have shown that JNK1 and JNK2 perform distinct functions through specific binding partners and substrates. JNKs are mitogen-activated protein kinases that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143380 [Multi-domain]  Cd Length: 364  Bit Score: 62.37  E-value: 1.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  19 RNVFRELEILQEIEH---VFLVNLWY---SFQDEEDMFMVVDLLlggdlRYHLQQNVQFSEDTVRL--YICEMALALDYL 90
Cdd:cd07875   68 KRAYRELVLMKCVNHkniIGLLNVFTpqkSLEEFQDVYIVMELM-----DANLCQVIQMELDHERMsyLLYQMLCGIKHL 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  91 RSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYE 170
Cdd:cd07875  143 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL-----GMGYKENVDIWSVGCIMGE 217

                 ....
gi 247269852 171 LLRG 174
Cdd:cd07875  218 MIKG 221
PTKc_Tec_like cd05059
Catalytic domain of Tec-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
3-229 1.12e-10

Catalytic domain of Tec-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Tec-like subfamily is composed of Tec, Btk, Bmx (Etk), Itk (Tsk, Emt), Rlk (Txk), and similar proteins. They are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, some members contain the Tec homology (TH) domain, which contains proline-rich and zinc-binding regions. Tec kinases form the second largest subfamily of nonreceptor PTKs and are expressed mainly by haematopoietic cells, although Tec and Bmx are also found in endothelial cells. B-cells express Btk and Tec, while T-cells express Itk, Txk, and Tec. Collectively, Tec kinases are expressed in a variety of myeloid cells such as mast cells, platelets, macrophages, and dendritic cells. Each Tec kinase shows a distinct cell-type pattern of expression. Tec kinases play important roles in the development, differentiation, maturation, regulation, survival, and function of B-cells and T-cells. Mutations in Btk cause the severe B-cell immunodeficiency, X-linked agammaglobulinaemia (XLA). The Tec-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173637 [Multi-domain]  Cd Length: 256  Bit Score: 61.31  E-value: 1.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDevrnVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC- 81
Cdd:cd05059   32 AIKMIKEGSMSEDD----FIEEAKVMMKLSHPKLVQLYGVCTKQRPIFIVTEYMANGCLLNYLRERRGKFQTEQLLEMCk 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERaTALAGTK---PYMAPEIFHSfvnggTGYSFE 158
Cdd:cd05059  108 DVCEAMEYLESNGFIHRDLAARNCLVGEQNVVKVSDFGLARYVLDDEY-TSSVGTKfpvKWSPPEVFMY-----SKFSSK 181
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 159 VDWWSVGVMAYELLR-GWRPYDIHS-SNAVESLVQLFSTvsvqYVPTW-SKEMVALLRKLLTVNPEHR--FSSLQD 229
Cdd:cd05059  182 SDVWSFGVLMWEVFSeGKMPYERFSnSEVVEHISQGYRL----YRPHLaPTEVYTIMYSCWHEKPEERptFKILLS 253
STKc_PFTAIRE1 cd07869
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase; STKs catalyze the transfer ...
1-174 1.43e-10

Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PFTAIRE-1 is widely expressed except in the spleen and thymus. It is highly expressed in the brain, heart, pancreas, testis, and ovary, and is localized in the cytoplasm. It is regulated by cyclin D3 and is inhibited by the p21 cell cycle inhibitor. It has also been shown to interact with the membrane-associated cyclin Y, which recruits the protein to the plasma membrane. PFTAIRE-1 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PFTAIRE-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143374 [Multi-domain]  Cd Length: 303  Bit Score: 61.63  E-value: 1.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQciERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd07869   32 LVALKVIRLQE--EEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPENVKLFL 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAtiikdgeRATALAG--------TKPYMAPEIFHsfvnGG 152
Cdd:cd07869  110 FQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLA-------RAKSVPShtysnevvTLWYRPPDVLL----GS 178
                        170       180
                 ....*....|....*....|..
gi 247269852 153 TGYSFEVDWWSVGVMAYELLRG 174
Cdd:cd07869  179 TEYSTCLDMWGVGCIFVEMIQG 200
STKc_ASK cd06624
Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase; STKs ...
2-178 1.56e-10

Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily are mitogen-activated protein kinase (MAPK) kinase kinases (MAPKKKs or MKKKs) and include ASK1, ASK2, and MAPKKK15. ASK1 (also called MAPKKK5) functions in the c-Jun N-terminal kinase (JNK) and p38 MAPK signaling pathways by directly activating their respective MAPKKs, MKK4/MKK7 and MKK3/MKK6. It plays important roles in cytokine and stress responses, as well as in reactive oxygen species-mediated cellular responses. ASK1 is implicated in various diseases mediated by oxidative stress including inschemic heart disease, hypertension, vessel injury, brain ischemia, Fanconi anemia, asthma, and pulmonary edema, among others. ASK2 (also called MAPKKK6) functions only in a heteromeric complex with ASK1, and can activate ASK1 by direct phosphorylation. The function of MAPKKK15 is still unknown. The ASK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270794 [Multi-domain]  Cd Length: 268  Bit Score: 60.88  E-value: 1.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCI------ERD--EVRNVFRELEILQEIEHVFLVNlwYSFQDEED----MFMvvDLLLGGDLRYHLQQN- 68
Cdd:cd06624   25 YAARDLSTQVRIaikeipERDsrEVQPLHEEIALHSRLSHKNIVQ--YLGSVSEDgffkIFM--EQVPGGSLSALLRSKw 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  69 --VQFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDE-QGHAHLTDF----NIATIikdGERATALAGTKPYMA 141
Cdd:cd06624  101 gpLKDNENTIGYYTKQILEGLKYLHDNKIVHRDIKGDNVLVNTySGVVKISDFgtskRLAGI---NPCTETFTGTLQYMA 177
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 247269852 142 PEIFHSfvnGGTGYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd06624  178 PEVIDK---GQRGYGPPADIWSLGCTIIEMATGKPPF 211
PKc_Myt1 cd14050
Catalytic domain of the Dual-specificity protein kinase, Myt1; Dual-specificity PKs catalyze ...
56-171 1.57e-10

Catalytic domain of the Dual-specificity protein kinase, Myt1; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. Myt1 is a cytoplasmic cell cycle checkpoint kinase that can keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of N-terminal thr (T14) and tyr (Y15) residues, leading to the delay of meiosis I entry. Meiotic progression is ensured by a two-step inhibition and downregulation of Myt1 by CDK1/XRINGO and p90Rsk during oocyte maturation. In addition, Myt1 targets cyclin B1/B2 and is essential for Golgi and ER assembly during telophase. In Drosophila, Myt1 may be a downstream target of Notch during eye development. The Myt1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270952 [Multi-domain]  Cd Length: 249  Bit Score: 60.79  E-value: 1.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  56 LLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAG 135
Cdd:cd14050   82 LCDTSLQQYCEETHSLPESEVWNILLDLLKGLKHLHDHGLIHLDIKPANIFLSKDGVCKLGDFGLVVELDKEDIHDAQEG 161
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 247269852 136 TKPYMAPEIfhsfVNGGTGYSfeVDWWSVGVMAYEL 171
Cdd:cd14050  162 DPRYMAPEL----LQGSFTKA--ADIFSLGITILEL 191
STKc_YSK4 cd06631
Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4; STKs ...
17-228 1.81e-10

Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. YSK4 is a putative MAPKKK, whose mammalian gene has been isolated. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The YSK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270801 [Multi-domain]  Cd Length: 266  Bit Score: 60.91  E-value: 1.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  17 EVRNVFRELEILQEIEHVFLVN-LWYSFQDEE-DMFMvvDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQH 94
Cdd:cd06631   46 EYEKLQEEVDLLKTLKHVNIVGyLGTCLEDNVvSIFM--EFVPGGSIASILARFGALEEPVFCRYTKQILEGVAYLHNNN 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  95 IIHRDVKPDNILLDEQGHAHLTDFNIA-------TIIKDGERATALAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVGVM 167
Cdd:cd06631  124 VIHRDIKGNNIMLMPNGVIKLIDFGCAkrlcinlSSGSQSQLLKSMRGTPYWMAPEVINE-----TGHGRKSDIWSIGCT 198
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 247269852 168 AYELLRGWRP----------YDIHS-SNAVESLVQLFSTVSVQYVptwskemvallRKLLTVNPEHRFSSLQ 228
Cdd:cd06631  199 VFEMATGKPPwadmnpmaaiFAIGSgRKPVPRLPDKFSPEARDFV-----------HACLTRDQDERPSAEQ 259
STKc_CaMK_like cd14088
Catalytic domain of an Uncharacterized group of Serine/Threonine kinases with similarity to ...
24-226 2.26e-10

Catalytic domain of an Uncharacterized group of Serine/Threonine kinases with similarity to Calcium/calmodulin-dependent protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of uncharacterized STKs with similarity to CaMKs, which are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). CaMKs contain an N-terminal catalytic domain followed by a regulatory domain that harbors a CaM binding site. This uncharacterized subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270990 [Multi-domain]  Cd Length: 265  Bit Score: 60.42  E-value: 2.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  24 ELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKPD 103
Cdd:cd14088   49 EINILKMVKHPNILQLVDVFETRKEYFIFLELATGREVFDWILDQGYYSERDTSNVIRQVLEAVAYLHSLKIVHRNLKLE 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 104 NIL-LDEQGHAHL--TDFNIA----TIIKDGeratalAGTKPYMAPEIFhsfvnGGTGYSFEVDWWSVGVMAYELLRGWR 176
Cdd:cd14088  129 NLVyYNRLKNSKIviSDFHLAklenGLIKEP------CGTPEYLAPEVV-----GRQRYGRPVDCWAIGVIMYILLSGNP 197
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 247269852 177 P---------YDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSS 226
Cdd:cd14088  198 PfydeaeeddYENHDKNLFRKILAGDYEFDSPYWDDISQAAKDLVTRLMEVEQDQRITA 256
PTZ00266 PTZ00266
NIMA-related protein kinase; Provisional
14-228 2.42e-10

NIMA-related protein kinase; Provisional


Pssm-ID: 173502 [Multi-domain]  Cd Length: 1021  Bit Score: 62.06  E-value: 2.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   14 ERDEVRNVFrELEILQEIEHVFLVNLWYSFQDE--EDMFMVVDLLLGGDLRYHLQQNVQF----SEDTVRLYICEMALAL 87
Cdd:PTZ00266   53 EREKSQLVI-EVNVMRELKHKNIVRYIDRFLNKanQKLYILMEFCDAGDLSRNIQKCYKMfgkiEEHAIVDITRQLLHAL 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   88 DYLRS-------QHIIHRDVKPDNILLD----------EQGH-------AHLTDFNIATIIKDGERATALAGTKPYMAPE 143
Cdd:PTZ00266  132 AYCHNlkdgpngERVLHRDLKPQNIFLStgirhigkitAQANnlngrpiAKIGDFGLSKNIGIESMAHSCVGTPYYWSPE 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  144 IfhsFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYdiHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHR 223
Cdd:PTZ00266  212 L---LLHETKSYDDKSDMWALGCIIYELCSGKTPF--HKANNFSQLISELKRGPDLPIKGKSKELNILIKNLLNLSAKER 286

                  ....*
gi 247269852  224 FSSLQ 228
Cdd:PTZ00266  287 PSALQ 291
STKc_PIM3 cd14102
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
3-179 2.42e-10

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3). PIM3 can inhibit apoptosis and promote cell survival and protein translation, therefore, it can enhance the proliferation of normal and cancer cells. Mice deficient with PIM3 show minimal effects, suggesting that PIM3 msy not be essential. Since its expression is enhanced in several cancers, it may make a good molecular target for cancer drugs. The PIM3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271004 [Multi-domain]  Cd Length: 253  Bit Score: 60.35  E-value: 2.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNVFRELEI--LQEIEHVF--LVNL--WYsfqDEEDMFMVV--DLLLGGDLRYHLQQNVQFSED 74
Cdd:cd14102   29 AVKHVVKERVTEWGTLNGVMVPLEIvlLKKVGSGFrgVIKLldWY---ERPDGFLIVmeRPEPVKDLFDFITEKGALDED 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  75 TVRLYICEMALALDYLRSQHIIHRDVKPDNILLD-EQGHAHLTDFNIATIIKDgERATALAGTKPYMAPEI--FHSFvng 151
Cdd:cd14102  106 TARGFFRQVLEAVRHCYSCGVVHRDIKDENLLVDlRTGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPEWirYHRY--- 181
                        170       180
                 ....*....|....*....|....*...
gi 247269852 152 gTGYSFEVdwWSVGVMAYELLRGWRPYD 179
Cdd:cd14102  182 -HGRSATV--WSLGVLLYDMVCGDIPFE 206
STKc_Unc-89_rpt2 cd14112
Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated ...
16-178 2.98e-10

Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The nematode Unc-89 gene, through alternative promoter use and splicing, encodes at least six major isoforms (Unc-89A to Unc-89F) of giant muscle proteins that are homologs for the vetebrate obscurin. In flies, five isoforms of Unc-89 have been detected: four in the muscles of adult flies (two in the indirect flight muscle and two in other muscles) and another isoform in the larva. Unc-89 in nematodes is required for normal muscle cell architecture. In flies, it is necessary for the development of a symmetrical sarcomere in the flight muscles. Unc-89 proteins contain several adhesion and signaling domains including multiple copies of the immunoglobulin (Ig) domain, as well as fibronectin type III (FN3), SH3, RhoGEF, and PH domains. The nematode Unc-89 isoforms D, C, D, and F contain two kinase domain with B and F having two complete kinase domains while the first repeat of C and D are partial domains. Homology modeling suggests that the first kinase repeat of Unc-89 may be catalytically inactive, a pseudokinase, while the second kinase repeat may be active. The Unc-89 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271014 [Multi-domain]  Cd Length: 259  Bit Score: 60.24  E-value: 2.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  16 DEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGgDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHI 95
Cdd:cd14112   42 DEASEAVREFESLRTLQHENVQRLIAAFKPSNFAYLVMEKLQE-DVFTRFSSNDYYSEEQVATTVRQILDALHYLHFKGI 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  96 IHRDVKPDNILLD--EQGHAHLTDFNIATIIKDGERATALAGTKpYMAPEifhsFVNGGTGYSFEVDWWSVGVMAYELLR 173
Cdd:cd14112  121 AHLDVQPDNIMFQsvRSWQVKLVDFGRAQKVSKLGKVPVDGDTD-WASPE----FHNPETPITVQSDIWGLGVLTFCLLS 195

                 ....*
gi 247269852 174 GWRPY 178
Cdd:cd14112  196 GFHPF 200
PTKc_FAK cd05056
Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; PTKs catalyze the ...
12-178 3.31e-10

Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. FAK is a cytoplasmic (or nonreceptor) PTK that contains an autophosphorylation site and a FERM domain at the N-terminus, a central tyr kinase domain, proline-rich regions, and a C-terminal FAT (focal adhesion targeting) domain. FAK activity is dependent on integrin-mediated cell adhesion, which facilitates N-terminal autophosphorylation. Full activation is achieved by the phosphorylation of its two adjacent A-loop tyrosines. FAK is important in mediating signaling initiated at sites of cell adhesions and at growth factor receptors. Through diverse molecular interactions, FAK functions as a biosensor or integrator to control cell motility. It is a key regulator of cell survival, proliferation, migration and invasion, and thus plays an important role in the development and progression of cancer. Src binds to autophosphorylated FAK forming the FAK-Src dual kinase complex, which is activated in a wide variety of tumor cells and generates signals promoting growth and metastasis. FAK is being developed as a target for cancer therapy. The FAK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133187 [Multi-domain]  Cd Length: 270  Bit Score: 60.13  E-value: 3.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  12 CIERDEVRNVFRELEILQEIEHVFLVNLwYSFQDEEDMFMVVDLLLGGDLRYHLQQN-VQFSEDTVRLYICEMALALDYL 90
Cdd:cd05056   45 CTSPSVREKFLQEAYIMRQFDHPHIVKL-IGVITENPVWIVMELAPLGELRSYLQVNkYSLDLASLILYAYQLSTALAYL 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  91 RSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKP--YMAPEI--FHSFvnggTGYSfevDWWSVGV 166
Cdd:cd05056  124 ESKRFVHRDIAARNVLVSSPDCVKLGDFGLSRYMEDESYYKASKGKLPikWMAPESinFRRF----TSAS---DVWMFGV 196
                        170
                 ....*....|...
gi 247269852 167 MAYELL-RGWRPY 178
Cdd:cd05056  197 CMWEILmLGVKPF 209
STKc_TEY_MAPK cd07858
Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases; ...
23-173 3.60e-10

Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Plant MAPKs are typed based on the conserved phosphorylation motif present in the activation loop, TEY and TDY. This subfamily represents the TEY subtype of plant MAPKs and is further subdivided into three groups (A, B, and C). Group A is represented by AtMPK3, AtMPK6, Nicotiana tabacum BTF4 (NtNTF4), among others. They are mostly involved in environmental and hormonal responses. AtMPK3 and AtMPK6 are also key regulators for stomatal development and patterning. Group B is represented by AtMPK4, AtMPK13, and NtNTF6, among others. They may be involved in both cell division and environmental stress response. AtMPK4 also participates in regulating innate immunity. Group C is represented by AtMPK1, AtMPK2, NtNTF3, Oryza sativa MAPK4 (OsMAPK4), among others. They may also be involved in stress responses. AtMPK1 and AtMPK2 are activated following mechanical injury and in the presence of stress chemicals such as jasmonic acid, hydrogen peroxide and abscisic acid. OsMAPK4 is also called OsMSRMK3 for Multiple Stress-Responsive MAPK3. In plants, MAPKs are associated with physiological, developmental, hormonal, and stress responses. Some plants show numerous gene duplications of MAPKs; Arabidopsis thaliana harbors at least 20 MAPKs, named AtMPK1-20. The TEY MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143363 [Multi-domain]  Cd Length: 337  Bit Score: 60.46  E-value: 3.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEH--------VFLVNLWYSFqdeEDMFMVVDLLlGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQH 94
Cdd:cd07858   53 REIKLLRHLDHenviaikdIMPPPHREAF---NDVYIVYELM-DTDLHQIIRSSQTLSDDHCQYFLYQLLRGLKYIHSAN 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  95 IIHRDVKPDNILLDEQGHAHLTDFNIA-TIIKDGERATALAGTKPYMAPEIFHSfvngGTGYSFEVDWWSVGVMAYELLR 173
Cdd:cd07858  129 VLHRDLKPSNLLLNANCDLKICDFGLArTTSEKGDFMTEYVVTRWYRAPELLLN----CSEYTTAIDVWSVGCIFAELLG 204
PTKc_Src_Fyn_like cd14203
Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
24-228 3.91e-10

Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily includes a subset of Src-like PTKs including Src, Fyn, Yrk, and Yes, which are all widely expressed. Yrk has been detected only in chickens. It is primarily found in neuronal and epithelial cells and in macrophages. It may play a role in inflammation and in response to injury. Src (or c-Src) proteins are cytoplasmic (or non-receptor) PTKs which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. They are also implicated in acute inflammatory responses and osteoclast function. The Src/Fyn-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271105 [Multi-domain]  Cd Length: 248  Bit Score: 59.54  E-value: 3.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  24 ELEILQEIEHVFLVNLwYSFQDEEDMFMV---------VDLLLGGDLRY-HLQQNVQFSedtvrlyiCEMALALDYLRSQ 93
Cdd:cd14203   40 EAQIMKKLRHDKLVQL-YAVVSEEPIYIVtefmskgslLDFLKDGEGKYlKLPQLVDMA--------AQIASGMAYIERM 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  94 HIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERaTALAGTK---PYMAPE--IFHSFvnggtgySFEVDWWSVGVMA 168
Cdd:cd14203  111 NYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEY-TARQGAKfpiKWTAPEaaLYGRF-------TIKSDVWSFGILL 182
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 247269852 169 YELL-RGWRPYDihSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHR--FSSLQ 228
Cdd:cd14203  183 TELVtKGRVPYP--GMNNREVLEQVERGYRMPCPPGCPESLHELMCQCWRKDPEERptFEYLQ 243
STKc_CDK9 cd07865
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9; STKs ...
23-226 4.77e-10

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK9, together with a cyclin partner (cyclin T1, T2a, T2b, or K), is the main component of distinct positive transcription elongation factors (P-TEFb), which function as Ser2 C-terminal domain kinases of RNA polymerase II. P-TEFb participates in multiple steps of gene expression including transcription elongation, mRNA synthesis, processing, export, and translation. It also plays a role in mediating cytokine induced transcription networks such as IL6-induced STAT3 signaling. In addition, the CDK9/cyclin T2a complex promotes muscle differentiation and enhances the function of some myogenic regulatory factors. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK9 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270848 [Multi-domain]  Cd Length: 310  Bit Score: 60.08  E-value: 4.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLW---------YSfQDEEDMFMVVDLL---LGGDLRYhlqQNVQFSEDTVRLYICEMALALDYL 90
Cdd:cd07865   60 REIKILQLLKHENVVNLIeicrtkatpYN-RYKGSIYLVFEFCehdLAGLLSN---KNVKFTLSEIKKVMKMLLNGLYYI 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  91 RSQHIIHRDVKPDNILLDEQGHAHLTDFNIA-----TIIKDGERATALAGTKPYMAPEIFHsfvnGGTGYSFEVDWWSVG 165
Cdd:cd07865  136 HRNKILHRDMKAANILITKDGVLKLADFGLArafslAKNSQPNRYTNRVVTLWYRPPELLL----GERDYGPPIDMWGAG 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 166 VMAYELlrgWRPYDIHSSNAVESLVQLFSTV----------SVQYVPTWSK----------------------EMVALLR 213
Cdd:cd07865  212 CIMAEM---WTRSPIMQGNTEQHQLTLISQLcgsitpevwpGVDKLELFKKmelpqgqkrkvkerlkpyvkdpYALDLID 288
                        250
                 ....*....|...
gi 247269852 214 KLLTVNPEHRFSS 226
Cdd:cd07865  289 KLLVLDPAKRIDA 301
STKc_LIMK1 cd14221
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1; STKs catalyze the ...
7-172 5.57e-10

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMK1 activation is induced by bone morphogenic protein, vascular endothelial growth factor, and thrombin. It plays roles in microtubule disassembly and cell cycle progression, and is critical in the regulation of neurite outgrowth. LIMK1 knockout mice show abnormalities in dendritic spine morphology and synaptic function. LIMK1 is one of the genes deleted in patients with Williams Syndrome, which is characterized by distinct craniofacial features, cardiovascular problems, as well as behavioral and neurological abnormalities. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. The LIMK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271123 [Multi-domain]  Cd Length: 267  Bit Score: 59.58  E-value: 5.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   7 MNKQQCIERDE--VRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLR---------YHLQQNVQFSEDt 75
Cdd:cd14221   21 MVMKELIRFDEetQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRgiiksmdshYPWSQRVSFAKD- 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  76 vrlyiceMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATII---------------KDGERATALAGTKPYM 140
Cdd:cd14221  100 -------IASGMAYLHSMNIIHRDLNSHNCLVRENKSVVVADFGLARLMvdektqpeglrslkkPDRKKRYTVVGNPYWM 172
                        170       180       190
                 ....*....|....*....|....*....|..
gi 247269852 141 APEIFHsfvngGTGYSFEVDWWSVGVMAYELL 172
Cdd:cd14221  173 APEMIN-----GRSYDEKVDVFSFGIVLCEII 199
STKc_MLK4 cd14146
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 4; STKs catalyze the ...
82-178 5.99e-10

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK4 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The specific function of MLK4 is yet to be determined. Mutations in the kinase domain of MLK4 have been detected in colorectal cancers. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation.The MLK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271048 [Multi-domain]  Cd Length: 268  Bit Score: 59.28  E-value: 5.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQH---IIHRDVKPDNILL------DEQGHAHL--TDFNIAtiiKDGERATAL--AGTKPYMAPEIFHSF 148
Cdd:cd14146  110 QIARGMLYLHEEAvvpILHRDLKSSNILLlekiehDDICNKTLkiTDFGLA---REWHRTTKMsaAGTYAWMAPEVIKSS 186
                         90       100       110
                 ....*....|....*....|....*....|
gi 247269852 149 VnggtgYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd14146  187 L-----FSKGSDIWSYGVLLWELLTGEVPY 211
STKc_LRRK1 cd14067
Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1; STKs catalyze ...
82-177 8.98e-10

Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRK1 is one of two vertebrate LRRKs which show complementary expression in the brain. It can form heterodimers with LRRK2, and may influence the age of onset of LRRK2-associated Parkinson's disease. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. The LRRK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270969 [Multi-domain]  Cd Length: 276  Bit Score: 58.82  E-value: 8.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNIL---LDEQGHAH--LTDFNIATIiKDGERATALAGTKPYMAPEIFHSFVnggtgYS 156
Cdd:cd14067  122 QIAAGLAYLHKKNIIFCDLKSDNILvwsLDVQEHINikLSDYGISRQ-SFHEGALGVEGTPGYQAPEIRPRIV-----YD 195
                         90       100
                 ....*....|....*....|.
gi 247269852 157 FEVDWWSVGVMAYELLRGWRP 177
Cdd:cd14067  196 EKVDMFSYGMVLYELLSGQRP 216
PTKc_FGFR cd05053
Catalytic domain of the Protein Tyrosine Kinases, Fibroblast Growth Factor Receptors; PTKs ...
3-227 1.00e-09

Catalytic domain of the Protein Tyrosine Kinases, Fibroblast Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The FGFR subfamily consists of FGFR1, FGFR2, FGFR3, FGFR4, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, and to heparin/heparan sulfate (HS) results in the formation of a ternary complex, which leads to receptor dimerization and activation, and intracellular signaling. There are at least 23 FGFs and four types of FGFRs. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. FGF/FGFR signaling is important in the regulation of embryonic development, homeostasis, and regenerative processes. Depending on the cell type and stage, FGFR signaling produces diverse cellular responses including proliferation, growth arrest, differentiation, and apoptosis. Aberrant signaling leads to many human diseases such as skeletal, olfactory, and metabolic disorders, as well as cancer. The FGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase .


Pssm-ID: 270646 [Multi-domain]  Cd Length: 294  Bit Score: 58.97  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKyMNKQQCIERDeVRNVFRELEILQEI-EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQN-----------VQ 70
Cdd:cd05053   47 AVK-MLKDDATEKD-LSDLVSEMEMMKMIgKHKNIINLLGACTQDGPLYVVVEYASKGNLREFLRARrppgeeaspddPR 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  71 FSEDTVRLY-----ICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIK--DGERATAlAGTKPY--MA 141
Cdd:cd05053  125 VPEEQLTQKdlvsfAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHhiDYYRKTT-NGRLPVkwMA 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 142 PEIFHSFVnggtgYSFEVDWWSVGVMAYELLR-GWRPYdihSSNAVESLVQLF-STVSVQYVPTWSKEMVALLRKLLTVN 219
Cdd:cd05053  204 PEALFDRV-----YTHQSDVWSFGVLLWEIFTlGGSPY---PGIPVEELFKLLkEGHRMEKPQNCTQELYMLMRDCWHEV 275
                        250
                 ....*....|
gi 247269852 220 PEHR--FSSL 227
Cdd:cd05053  276 PSQRptFKQL 285
PTKc_Tec_Rlk cd05114
Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular ...
3-190 1.07e-09

Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tec and Rlk (also named Txk) are members of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. Instead of PH, Rlk contains an N-terminal cysteine-rich region. In addition to PH, Tec also contains the Tec homology (TH) domain with proline-rich and zinc-binding regions. Tec kinases are expressed mainly by haematopoietic cells. Tec is more widely-expressed than other Tec-like subfamily kinases. It is found in endothelial cells, both B- and T-cells, and a variety of myeloid cells including mast cells, erythroid cells, platelets, macrophages and neutrophils. Rlk is expressed in T-cells and mast cell lines. Tec and Rlk are both key components of T-cell receptor (TCR) signaling. They are important in TCR-stimulated proliferation, IL-2 production and phopholipase C-gamma1 activation. The Tec/Rlk subfamily is part of a larger superfamily, that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270685 [Multi-domain]  Cd Length: 260  Bit Score: 58.33  E-value: 1.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRnvfrELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNV-QFSED---TVRL 78
Cdd:cd05114   32 AIKAIREGAMSEEDFIE----EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMENGCLLNYLRQRRgKLSRDmllSMCQ 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEmalALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKP--YMAPEIFHSfvnggTGYS 156
Cdd:cd05114  108 DVCE---GMEYLERNNFIHRDLAARNCLVNDTGVVKVSDFGMTRYVLDDQYTSSSGAKFPvkWSPPEVFNY-----SKFS 179
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 247269852 157 FEVDWWSVGVMAYELL-RGWRPYDIHSSNAVESLV 190
Cdd:cd05114  180 SKSDVWSFGVLMWEVFtEGKMPFESKSNYEVVEMV 214
PKc_LIMK_like cd14065
Catalytic domain of the LIM domain kinase-like protein kinases; PKs catalyze the transfer of ...
16-172 1.07e-09

Catalytic domain of the LIM domain kinase-like protein kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. Members of this subfamily include LIMK, Testicular or testis-specific protein kinase (TESK), and similar proteins. LIMKs are characterized as serine/threonine kinases (STKs) while TESKs are dual-specificity protein kinases. Both LIMK and TESK phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They are implicated in many cellular functions including cell spreading, motility, morphogenesis, meiosis, mitosis, and spermatogenesis. The LIMK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270967 [Multi-domain]  Cd Length: 252  Bit Score: 58.27  E-value: 1.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  16 DEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI-CEMALALDYLRSQH 94
Cdd:cd14065   30 DEQRSFLKEVKLMRRLSHPNILRFIGVCVKDNKLNFITEYVNGGTLEELLKSMDEQLPWSQRVSLaKDIASGMAYLHSKN 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  95 IIHRDVKPDNILLDEQG---HAHLTDFNIATII-----KDGERATALA--GTKPYMAPEIFHsfvngGTGYSFEVDWWSV 164
Cdd:cd14065  110 IIHRDLNSKNCLVREANrgrNAVVADFGLAREMpdektKKPDRKKRLTvvGSPYWMAPEMLR-----GESYDEKVDVFSF 184

                 ....*...
gi 247269852 165 GVMAYELL 172
Cdd:cd14065  185 GIVLCEII 192
PTKc_Tyk2_rpt2 cd05080
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; PTKs catalyze ...
23-178 1.37e-09

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tyk2 is widely expressed in many tissues. It is involved in signaling via the cytokine receptors IFN-alphabeta, IL-6, IL-10, IL-12, IL-13, and IL-23. It mediates cell surface urokinase receptor (uPAR) signaling and plays a role in modulating vascular smooth muscle cell (VSMC) functional behavior in response to injury. Tyk2 is also important in dendritic cell function and T helper (Th)1 cell differentiation. A homozygous mutation of Tyk2 was found in a patient with hyper-IgE syndrome (HIES), a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and elevated serum IgE. This suggests that Tyk2 may play important roles in multiple cytokine signaling involved in innate and adaptive immunity. Tyk2 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase catalytic domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The Tyk2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270664 [Multi-domain]  Cd Length: 283  Bit Score: 58.37  E-value: 1.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNlwY----SFQDEEDMFMVVDLLLGGDLRYHLQQNvQFSEDTVRLY---ICEmalALDYLRSQHI 95
Cdd:cd05080   55 QEIDILKTLYHENIVK--YkgccSEQGGKSLQLIMEYVPLGSLRDYLPKH-SIGLAQLLLFaqqICE---GMAYLHSQHY 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  96 IHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALA--GTKP--YMAPEIFHSFvnggtGYSFEVDWWSVGVMAYEL 171
Cdd:cd05080  129 IHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVRedGDSPvfWYAPECLKEY-----KFYYASDVWSFGVTLYEL 203

                 ....*..
gi 247269852 172 LRGWRPY 178
Cdd:cd05080  204 LTHCDSS 210
PTKc_Jak1_rpt2 cd05079
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1; PTKs catalyze the ...
16-230 1.46e-09

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak1 is widely expressed in many tissues. Many cytokines are dependent on Jak1 for signaling, including those that use the shared receptor subunits common gamma chain (IL-2, IL-4, IL-7, IL-9, IL-15, IL-21) and gp130 (IL-6, IL-11, oncostatin M, G-CSF, and IFNs, among others). The many varied interactions of Jak1 and its ubiquitous expression suggest many biological roles. Jak1 is important in neurological development, as well as in lymphoid development and function. It also plays a role in the pathophysiology of cardiac hypertrophy and heart failure. A mutation in the ATP-binding site of Jak1 was identified in a human uterine leiomyosarcoma cell line, resulting in defective cytokine induction and antigen presentation, thus allowing the tumor to evade the immune system. Jak1 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The Jak1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173644 [Multi-domain]  Cd Length: 284  Bit Score: 58.40  E-value: 1.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  16 DEVRNVFRELEILQEIEHVFLVNLWYSFQDEED--MFMVVDLLLGGDLRYHLQQNV-QFSEDTVRLYICEMALALDYLRS 92
Cdd:cd05079   48 NHIADLKKEIEILRNLYHENIVKYKGICTEDGGngIKLIMEFLPSGSLKEYLPRNKnKINLKQQLKYAVQICKGMDYLGS 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKP----YMAPE-IFHSfvnggtGYSFEVDWWSVGVM 167
Cdd:cd05079  128 RQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDLDspvfWYAPEcLIQS------KFYIASDVWSFGVT 201
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 168 AYELL----RGWRPYDI--------HSSNAVESLVQ-LFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRfSSLQDM 230
Cdd:cd05079  202 LYELLtycdSESSPMTLflkmigptHGQMTVTRLVRvLEEGKRLPRPPNCPEEVYQLMRKCWEFQPSKR-TTFQNL 276
STKc_WNK3 cd14031
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3; STKs catalyze ...
13-178 1.47e-09

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK3 shows a restricted expression pattern; it is found at high levels in the pituary glands and is also expressed in the kidney and brain. It has been shown to regulate many ion transporters including members of the SLC12A family of cation-chloride cotransporters such as NCC and NKCC2, the renal potassium channel ROMK, and the epithelial calcium channels TRPV5 and TRPV6. WNK3 appears to sense low-chloride hypotonic stress and under these conditions, it activates SPAK, which directly interacts and phosphorylates cation-chloride cotransporters. WNK3 has also been shown to promote cell survival, possibly through interaction with procaspase-3 and HSP70. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. The WNK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270933 [Multi-domain]  Cd Length: 275  Bit Score: 58.19  E-value: 1.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  13 IERDEVRNVFRELEILQEIEHVFLVNLWYSFQD----EEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALD 88
Cdd:cd14031   48 LTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESvlkgKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQ 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  89 YL--RSQHIIHRDVKPDNILLD-EQGHAHLTDFNIATIIKDgERATALAGTKPYMAPEIFHSFvnggtgYSFEVDWWSVG 165
Cdd:cd14031  128 FLhtRTPPIIHRDLKCDNIFITgPTGSVKIGDLGLATLMRT-SFAKSVIGTPEFMAPEMYEEH------YDESVDVYAFG 200
                        170
                 ....*....|...
gi 247269852 166 VMAYELLRGWRPY 178
Cdd:cd14031  201 MCMLEMATSEYPY 213
PTKc_Fes_like cd05041
Catalytic domain of Fes-like Protein Tyrosine Kinases; Protein Tyrosine Kinase (PTK) family; ...
16-178 1.51e-09

Catalytic domain of Fes-like Protein Tyrosine Kinases; Protein Tyrosine Kinase (PTK) family; Fes subfamily; catalytic (c) domain. Fes subfamily members include Fes (or Fps), Fer, and similar proteins. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fes subfamily proteins are cytoplasmic (or nonreceptor) tyr kinases containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. The genes for Fes (feline sarcoma) and Fps (Fujinami poultry sarcoma) were first isolated from tumor-causing retroviruses. The viral oncogenes encode chimeric Fes proteins consisting of Gag sequences at the N-termini, resulting in unregulated tyr kinase activity. Fes and Fer kinases play roles in haematopoiesis, inflammation and immunity, growth factor signaling, cytoskeletal regulation, cell migration and adhesion, and the regulation of cell-cell interactions. Fes and Fer show redundancy in their biological functions.


Pssm-ID: 270637 [Multi-domain]  Cd Length: 251  Bit Score: 57.84  E-value: 1.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  16 DEVRNVF-RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQN---------VQFSEDTvrlyicemAL 85
Cdd:cd05041   34 PDLKRKFlQEARILKQYDHPNIVKLIGVCVQKQPIMIVMELVPGGSLLTFLRKKgarltvkqlLQMCLDA--------AA 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  86 ALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERaTALAGTK----PYMAPEIfhsfVNGGTgYSFEVDW 161
Cdd:cd05041  106 GMEYLESKNCIHRDLAARNCLVGENNVLKISDFGMSREEEDGEY-TVSDGLKqipiKWTAPEA----LNYGR-YTSESDV 179
                        170
                 ....*....|....*...
gi 247269852 162 WSVGVMAYELLR-GWRPY 178
Cdd:cd05041  180 WSFGILLWEIFSlGATPY 197
PKc_DYRK cd14210
Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and ...
56-174 1.59e-09

Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase; Protein Kinases (PKs), Dual-specificity tYrosine-phosphorylated and -Regulated Kinase (DYRK) subfamily, catalytic (c) domain. Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. The DYRK subfamily is part of a larger superfamily that includes the catalytic domains of other protein S/T PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. They play important roles in cell proliferation, differentiation, survival, and development. Vertebrates contain multiple DYRKs (DYRK1-4) and mammals contain two types of DYRK1 proteins, DYRK1A and DYRK1B. DYRK1A is involved in neuronal differentiation and is implicated in the pathogenesis of DS (Down syndrome). DYRK1B plays a critical role in muscle differentiation by regulating transcription, cell motility, survival, and cell cycle progression. It is overexpressed in many solid tumors where it acts as a tumor survival factor. DYRK2 promotes apoptosis in response to DNA damage by phosphorylating the tumor suppressor p53, while DYRK3 promotes cell survival by phosphorylating SIRT1 and promoting p53 deacetylation. DYRK4 is a testis-specific kinase that may function during spermiogenesis.


Pssm-ID: 271112 [Multi-domain]  Cd Length: 311  Bit Score: 58.32  E-value: 1.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  56 LLGGDLRYHLQQN--VQFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDeqghaHLTDFNIaTII------KDG 127
Cdd:cd14210   96 LLSINLYELLKSNnfQGLSLSLIRKFAKQILQALQFLHKLNIIHCDLKPENILLK-----QPSKSSI-KVIdfgsscFEG 169
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 247269852 128 ERATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLRG 174
Cdd:cd14210  170 EKVYTYIQSRFYRAPEVIL-----GLPYDTAIDMWSLGCILAELYTG 211
PTKc_c-ros cd05044
Catalytic domain of the Protein Tyrosine Kinase, C-ros; PTKs catalyze the transfer of the ...
45-230 1.90e-09

Catalytic domain of the Protein Tyrosine Kinase, C-ros; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily contains c-ros, Sevenless, and similar proteins. The proto-oncogene c-ros encodes an orphan receptor PTK (RTK) with an unknown ligand. RTKs contain an extracellular ligand-binding domain, a transmembrane region, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. C-ros is expressed in embryonic cells of the kidney, intestine and lung, but disappears soon after birth. It persists only in the adult epididymis. Male mice bearing inactive mutations of c-ros lack the initial segment of the epididymis and are infertile. The Drosophila protein, Sevenless, is required for the specification of the R7 photoreceptor cell during eye development. The c-ros subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270640 [Multi-domain]  Cd Length: 268  Bit Score: 57.81  E-value: 1.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  45 DEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEM-ALALD------YLRSQHIIHRDVKPDNILLDEQGHAHLT- 116
Cdd:cd05044   70 DNDPQYIILELMEGGDLLSYLRAARPTAFTPPLLTLKDLlSICVDvakgcvYLEDMHFVHRDLAARNCLVSSKDYRERVv 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 117 ---DFNIATII-------KDGEratalaGTKP--YMAPEifhSFVNGgtGYSFEVDWWSVGVMAYELL-RGWRPYDIHSS 183
Cdd:cd05044  150 kigDFGLARDIykndyyrKEGE------GLLPvrWMAPE---SLVDG--VFTTQSDVWAFGVLMWEILtLGQQPYPARNN 218
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 247269852 184 NAVESLVQlfSTVSVQYVPTWSKEMVALLRKLLTVNPEHR--FSSLQDM 230
Cdd:cd05044  219 LEVLHFVR--AGGRLDQPDNCPDDLYELMLRCWSTDPEERpsFARILEQ 265
PTKc_ALK_LTK cd05036
Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte ...
12-190 1.97e-09

Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyr residues in protein substrates. ALK and LTK are orphan receptor PTKs (RTKs) whose ligands are not yet well-defined. ALK appears to play an important role in mammalian neural development as well as visceral muscle differentiation in Drosophila. ALK is aberrantly expressed as fusion proteins, due to chromosomal translocations, in about 60% of anaplastic large cell lymphomas (ALCLs). ALK fusion proteins are also found in rare cases of diffuse large B cell lymphomas (DLBCLs). LTK is mainly expressed in B lymphocytes and neuronal tissues. It is important in cell proliferation and survival. Transgenic mice expressing TLK display retarded growth and high mortality rate. In addition, a polymorphism in mouse and human LTK is implicated in the pathogenesis of systemic lupus erythematosus. RTKs contain an extracellular ligand-binding domain, a transmembrane region, and an intracellular tyr kinase domain. They are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The ALK/LTK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270632 [Multi-domain]  Cd Length: 277  Bit Score: 57.78  E-value: 1.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  12 CIERDEVrNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICE-MALALD-- 88
Cdd:cd05036   48 CSEQDEM-DFLMEALIMSKFNHPNIVRCIGVCFQRLPRFILLELMAGGDLKSFLRENRPRPEQPSSLTMLDlLQLAQDva 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  89 ----YLRSQHIIHRDVKPDNILLDEQGH---AHLTDFNIAtiiKDGERAT-------ALAGTKpYMAPEIFHSFVnggtg 154
Cdd:cd05036  127 kgcrYLEENHFIHRDIAARNCLLTCKGPgrvAKIGDFGMA---RDIYRADyyrkggkAMLPVK-WMPPEAFLDGI----- 197
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 247269852 155 YSFEVDWWSVGVMAYELLR-GWRPYDIHSSNAVESLV 190
Cdd:cd05036  198 FTSKTDVWSFGVLLWEIFSlGYMPYPGKSNQEVMEFV 234
STKc_MLK3 cd14147
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3; STKs catalyze the ...
19-178 2.33e-09

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK3 is a mitogen-activated protein kinase kinase kinases (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MLK3 activates multiple MAPK pathways and plays a role in apoptosis, proliferation, migration, and differentiation, depending on the cellular context. It is highly expressed in breast cancer cells and its signaling through c-Jun N-terminal kinase has been implicated in the migration, invasion, and malignancy of cancer cells. MLK3 also functions as a negative regulator of Inhibitor of Nuclear Factor-KappaB Kinase (IKK) and consequently, it also impacts inflammation and immunity. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation.The MLK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271049 [Multi-domain]  Cd Length: 267  Bit Score: 57.73  E-value: 2.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  19 RNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNvQFSEDTVRLYICEMALALDYLRSQHI--- 95
Cdd:cd14147   47 ESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGR-RVPPHVLVNWAVQIARGMHYLHCEALvpv 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  96 IHRDVKPDNILLDEQGHAH--------LTDFNIAtiiKDGERATAL--AGTKPYMAPEIFHSfvnggTGYSFEVDWWSVG 165
Cdd:cd14147  126 IHRDLKSNNILLLQPIENDdmehktlkITDFGLA---REWHKTTQMsaAGTYAWMAPEVIKA-----STFSKGSDVWSFG 197
                        170
                 ....*....|...
gi 247269852 166 VMAYELLRGWRPY 178
Cdd:cd14147  198 VLLWELLTGEVPY 210
STKc_LRRK2 cd14068
Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2; STKs catalyze ...
3-228 2.40e-09

Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRK2 is one of two vertebrate LRRKs which show complementary expression in the brain. Mutations in LRRK2, found in the kinase, ROC-COR, and WD40 domains, are linked to both familial and sporadic forms of Parkinson's disease. The most prevalent mutation, G2019S located in the activation loop of the kinase domain, increases kinase activity. The R1441C/G mutations in the GTPase domain have also been reported to influence kinase activity. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. The LRRK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270970 [Multi-domain]  Cd Length: 252  Bit Score: 57.27  E-value: 2.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQcierdEVRNVFRELEILQEIEHVFLVNLWYSfqDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC- 81
Cdd:cd14068   21 AVKIFNKHT-----SFRLLRQELVVLSHLHHPSLVALLAA--GTAPRMLVMELAPKGSLDALLQQDNASLTRTLQHRIAl 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILL-----DEQGHAHLTDFNIAT-IIKDGERATalAGTKPYMAPEIfhsfVNGGTGY 155
Cdd:cd14068   94 HVADGLRYLHSAMIIYRDLKPHNVLLftlypNCAIIAKIADYGIAQyCCRMGIKTS--EGTPGFRAPEV----ARGNVIY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 156 SFEVDWWSVGVMAYELLRGwrpydihSSNAVESLV--QLFSTVSVQ-YVPTWSKE--------MVALLRKLLTVNPEHRF 224
Cdd:cd14068  168 NQQADVYSFGLLLYDILTC-------GERIVEGLKfpNEFDELAIQgKLPDPVKEygcapwpgVEALIKDCLKENPQCRP 240

                 ....
gi 247269852 225 SSLQ 228
Cdd:cd14068  241 TSAQ 244
PK_STRAD_beta cd08226
Pseudokinase domain of STE20-related kinase adapter protein beta; The pseudokinase domain ...
86-178 3.35e-09

Pseudokinase domain of STE20-related kinase adapter protein beta; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity.STRAD-beta is also referred to as ALS2CR2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein), since the human gene encoding it is located within the juvenile ALS2 critical region on chromosome 2q33-q34. It is not linked to the development of ALS2. STRAD forms a complex with the scaffolding protein MO25, and the serine/threonine kinase (STK), LKB1, resulting in the activation of the kinase. In the complex, LKB1 phosphorylates and activates adenosine monophosphate-activated protein kinases (AMPKs), which regulate cell energy metabolism and cell polarity. LKB1 is a tumor suppressor linked to the rare inherited disease, Peutz-Jeghers syndrome, which is characterized by a predisposition to benign polyps and hyperpigmentation of the buccal mucosa. The STRAD-beta subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270864 [Multi-domain]  Cd Length: 328  Bit Score: 57.57  E-value: 3.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  86 ALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFN-IATIIKDGERATAL-------AGTKPYMAPEIFHSFVNggtGYSF 157
Cdd:cd08226  113 ALNYLHQNGCIHRSVKASHILISGDGLVSLSGLShLYSMVTNGQRSKVVydfpqfsTSVLPWLSPELLRQDLH---GYNV 189
                         90       100
                 ....*....|....*....|.
gi 247269852 158 EVDWWSVGVMAYELLRGWRPY 178
Cdd:cd08226  190 KSDIYSVGITACELARGQVPF 210
STKc_PIM2 cd14101
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
40-242 3.56e-09

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are three PIM2 isoforms resulting from alternative translation initiation sites. PIM2 is highly expressed in leukemia and lymphomas and has been shown to promote the survival and proliferation of tumor cells. The PIM2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271003 [Multi-domain]  Cd Length: 257  Bit Score: 56.78  E-value: 3.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  40 WYSFQDEedmFMVV--DLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLD-EQGHAHLT 116
Cdd:cd14101   75 WFEIPEG---FLLVleRPQHCQDLFDYITERGALDESLARRFFKQVVEAVQHCHSKGVVHRDIKDENILVDlRTGDIKLI 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 117 DFNIATIIKDgERATALAGTKPYMAPE--IFHSFvnggtgYSFEVDWWSVGVMAYELLRGWRPYDiHSSNAVESLVQLFS 194
Cdd:cd14101  152 DFGSGATLKD-SMYTDFDGTRVYSPPEwiLYHQY------HALPATVWSLGILLYDMVCGDIPFE-RDTDILKAKPSFNK 223
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 247269852 195 TVsvqyvptwSKEMVALLRKLLTVNPEHRfsslqdmqtaPSLAHVLWD 242
Cdd:cd14101  224 RV--------SNDCRSLIRSCLAYNPSDR----------PSLEQILLH 253
STKc_PIM1 cd14100
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
73-234 3.70e-09

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are two PIM1 isoforms resulting from alternative translation initiation sites. PIM1 is the founding member of the PIM subfamily. It is involved in regulating cell growth, differentiation, and apoptosis. It promotes cancer development when overexpressed by inhibiting apoptosis, promoting cell proliferation, and promoting genomic instability. The PIM1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271002 [Multi-domain]  Cd Length: 254  Bit Score: 56.90  E-value: 3.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  73 EDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLD-EQGHAHLTDFNIATIIKDgERATALAGTKPYMAPEI--FHSFv 149
Cdd:cd14100  105 EELARSFFRQVLEAVRHCHNCGVLHRDIKDENILIDlNTGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPEWirFHRY- 182
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 150 nggTGYSFEVdwWSVGVMAYELLRGWRPYDiHSSNAVESLVQLFSTVsvqyvptwSKEMVALLRKLLTVNPEHRfSSLQD 229
Cdd:cd14100  183 ---HGRSAAV--WSLGILLYDMVCGDIPFE-HDEEIIRGQVFFRQRV--------SSECQHLIKWCLALRPSDR-PSFED 247

                 ....*
gi 247269852 230 MQTAP 234
Cdd:cd14100  248 IQNHP 252
PTKc_FGFR1 cd05098
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; PTKs ...
7-223 3.80e-09

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Alternative splicing of FGFR1 transcripts produces a variety of isoforms, which are differentially expressed in cells. FGFR1 binds the ligands, FGF1 and FGF2, with high affinity and has also been reported to bind FGF4, FGF6, and FGF9. FGFR1 signaling is critical in the control of cell migration during embryo development. It promotes cell proliferation in fibroblasts. Nuclear FGFR1 plays a role in the regulation of transcription. Mutations, insertions or deletions of FGFR1 have been identified in patients with Kallman's syndrome (KS), an inherited disorder characterized by hypogonadotropic hypogonadism and loss of olfaction. Aberrant FGFR1 expression has been found in some human cancers including 8P11 myeloproliferative syndrome (EMS), breast cancer, and pancreatic adenocarcinoma. FGFR1 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270678 [Multi-domain]  Cd Length: 302  Bit Score: 57.33  E-value: 3.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   7 MNKQQCIERDeVRNVFRELEILQEI-EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQ------------------Q 67
Cdd:cd05098   52 MLKSDATEKD-LSDLISEMEMMKMIgKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQarrppgmeycynpshnpeE 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  68 NVQFSEDTVRLYicEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIK--DGERATAlAGTKP--YMAPE 143
Cdd:cd05098  131 QLSSKDLVSCAY--QVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHhiDYYKKTT-NGRLPvkWMAPE 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 144 IFHSFVnggtgYSFEVDWWSVGVMAYELLR-GWRPYdihSSNAVESLVQLFSTVSVQYVPT-WSKEMVALLRKLLTVNPE 221
Cdd:cd05098  208 ALFDRI-----YTHQSDVWSFGVLLWEIFTlGGSPY---PGVPVEELFKLLKEGHRMDKPSnCTNELYMMMRDCWHAVPS 279

                 ..
gi 247269852 222 HR 223
Cdd:cd05098  280 QR 281
PTZ00284 PTZ00284
protein kinase; Provisional
80-181 4.14e-09

protein kinase; Provisional


Pssm-ID: 140307 [Multi-domain]  Cd Length: 467  Bit Score: 57.67  E-value: 4.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEMALALDYLRSQ-HIIHRDVKPDNILL-------DEQGHAHLTDFNIATIIKD-----GER--ATALAGTKPYMAPEI 144
Cdd:PTZ00284 237 IFQTGVALDYFHTElHLMHTDLKPENILMetsdtvvDPVTNRALPPDPCRVRICDlggccDERhsRTAIVSTRHYRSPEV 316
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 247269852 145 FHsfvngGTGYSFEVDWWSVGVMAYELLRGWRPYDIH 181
Cdd:PTZ00284 317 VL-----GLGWMYSTDMWSMGCIIYELYTGKLLYDTH 348
PTKc_Zap-70 cd05115
Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa; PTKs ...
15-223 4.52e-09

Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Zap-70 is a cytoplasmic (or nonreceptor) PTK containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. Zap-70 is primarily expressed in T-cells and NK cells, and is a crucial component in T-cell receptor (TCR) signaling. Zap-70 binds the phosphorylated ITAM (immunoreceptor tyr activation motif) sequences of the activated TCR zeta-chain through its SH2 domains, leading to its phosphorylation and activation. It then phosphorylates target proteins, which propagate the signals to downstream pathways. Zap-70 is hardly detected in normal peripheral B-cells, but is present in some B-cell malignancies. It is used as a diagnostic marker for chronic lymphocytic leukemia (CLL) as it is associated with the more aggressive subtype of the disease. The Zap-70 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270686 [Multi-domain]  Cd Length: 269  Bit Score: 56.88  E-value: 4.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  15 RDEVrnvFRELEILQEIEHVFLVNLwYSFQDEEDMFMVVDLLLGGDLRYHLQ-QNVQFSEDTVRLYICEMALALDYLRSQ 93
Cdd:cd05115   48 RDEM---MREAQIMHQLDNPYIVRM-IGVCEAEALMLVMEMASGGPLNKFLSgKKDEITVSNVVELMHQVSMGMKYLEEK 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  94 HIIHRDVKPDNILLDEQGHAHLTDFNIATII-KDGERATALAGTK---PYMAPEI--FHSFvnggtgySFEVDWWSVGVM 167
Cdd:cd05115  124 NFVHRDLAARNVLLVNQHYAKISDFGLSKALgADDSYYKARSAGKwplKWYAPECinFRKF-------SSRSDVWSYGVT 196
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 168 AYELLR-GWRPYDIHSSNAVESLVQLFSTVSVQyvPTWSKEMVALLRKLLTVNPEHR 223
Cdd:cd05115  197 MWEAFSyGQKPYKKMKGPEVMSFIEQGKRMDCP--AECPPEMYALMSDCWIYKWEDR 251
STKc_CK2_alpha cd14132
Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2; STKs catalyze the ...
71-172 5.01e-09

Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CK2 is a tetrameric protein with two catalytic (alpha) and two regulatory (beta) subunits. It is constitutively active and ubiquitously expressed, and is found in the cytoplasm, nucleus, as well as in the plasma membrane. It phosphorylates a wide variety of substrates including gylcogen synthase, cell cycle proteins, nuclear proteins (e.g. DNA topoisomerase II), and ion channels (e.g. ENaC), among others. It may be considered a master kinase controlling the activity or lifespan of many other kinases and exerting its effect over cell fate, gene expression, protein synthesis and degradation, and viral infection. CK2 is implicated in every stage of the cell cycle and is required for cell cycle progression. It plays crucial roles in cell differentiation, proliferation, and survival, and is thus implicated in cancer. CK2 is not an oncogene by itself but elevated CK2 levels create an environment that enhances the survival of tumor cells. The CK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271034 [Multi-domain]  Cd Length: 306  Bit Score: 56.78  E-value: 5.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  71 FSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDeqgHAH----LTDFNIATIIKDGERATALAGTKPYMAPEIFH 146
Cdd:cd14132  109 LTDYDIRYYMYELLKALDYCHSKGIMHRDVKPHNIMID---HEKrklrLIDWGLAEFYHPGQEYNVRVASRYYKGPELLV 185
                         90       100
                 ....*....|....*....|....*.
gi 247269852 147 SFVNggtgYSFEVDWWSVGVMAYELL 172
Cdd:cd14132  186 DYQY----YDYSLDMWSLGCMLASMI 207
STKc_SRPK cd14136
Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase; STKs catalyze ...
85-174 5.93e-09

Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SRPKs phosphorylate and regulate splicing factors from the SR protein family by specifically phosphorylating multiple serine residues residing in SR/RS dipeptide motifs (also known as RS domains). Phosphorylation of the RS domains enhances interaction with transportin SR and facilitates entry of the SR proteins into the nucleus. SRPKs contain a nonconserved insert domain, within the well-conserved catalytic kinase domain, that regulates their subcellular localization. They play important roles in mediating pre-mRNA processing and mRNA maturation, as well as other cellular functions such as chromatin reorganization, cell cycle and p53 regulation, and metabolic signaling. Vertebrates contain three distinct SRPKs, called SRPK1-3. The SRPK homolog in budding yeast, Sky1p, recognizes and phosphorylates its substrate Npl3p, which lacks a classic RS domain but contains a single RS dipeptide at the C-terminus of its RGG domain. Npl3p is a shuttling heterogeneous nuclear ribonucleoprotein (hnRNP) that exports a distinct class of mRNA from the nucleus to the cytoplasm. The SRPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271038 [Multi-domain]  Cd Length: 320  Bit Score: 56.82  E-value: 5.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  85 LALDYLRSQ-HIIHRDVKPDNILLDEQG-HAHLTDFNIATIIKdgERATALAGTKPYMAPEifhsfVNGGTGYSFEVDWW 162
Cdd:cd14136  130 QGLDYLHTKcGIIHTDIKPENVLLCISKiEVKIADLGNACWTD--KHFTEDIQTRQYRSPE-----VILGAGYGTPADIW 202
                         90
                 ....*....|..
gi 247269852 163 SVGVMAYELLRG 174
Cdd:cd14136  203 STACMAFELATG 214
STKc_CDC2L1 cd07843
Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1; STKs catalyze ...
23-225 6.24e-09

Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDC2L1, also called PITSLRE, exists in different isoforms which are named using the alias CDK11(p). The CDC2L1 gene produces two protein products, CDK11(p110) and CDK11(p58). CDC2L1 is also represented by the caspase-processed CDK11(p46). CDK11(p110), the major isoform, associates with cyclin L and is expressed throughout the cell cycle. It is involved in RNA processing and the regulation of transcription. CDK11(p58) associates with cyclin D3 and is expressed during the G2/M phase of the cell cycle. It plays roles in spindle morphogenesis, centrosome maturation, sister chromatid cohesion, and the completion of mitosis. CDK11(p46) is formed from the larger isoforms by caspases during TNFalpha- and Fas-induced apoptosis. It functions as a downstream effector kinase in apoptotic signaling pathways and interacts with eukaryotic initiation factor 3f (eIF3f), p21-activated kinase (PAK1), and Ran-binding protein (RanBPM). CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDC2L1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173741 [Multi-domain]  Cd Length: 293  Bit Score: 56.46  E-value: 6.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWY----SFQDeeDMFMVVDLLlGGDLRYHLQQNVQ-FSEDTVRLYICEMALALDYLRSQHIIH 97
Cdd:cd07843   53 REINILLKLQHPNIVTVKEvvvgSNLD--KIYMVMEYV-EHDLKSLMETMKQpFLQSEVKCLMLQLLSGVAHLHDNWILH 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  98 RDVKPDNILLDEQGHAHLTDFNIATIIKDGERA-TALAGTKPYMAPEIFHsfvnGGTGYSFEVDWWSVGVMAYELLRGwR 176
Cdd:cd07843  130 RDLKTSNLLLNNRGILKICDFGLAREYGSPLKPyTQLVVTLWYRAPELLL----GAKEYSTAIDMWSVGCIFAELLTK-K 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 177 PYdIHSSNAVESLVQLFSTVSVQYVPTW-------------------------------SKEMVALLRKLLTVNPEHRFS 225
Cdd:cd07843  205 PL-FPGKSEIDQLNKIFKLLGTPTEKIWpgfselpgakkktftkypynqlrkkfpalslSDNGFDLLNRLLTYDPAKRIS 283
STKc_WNK4 cd14033
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4; STKs catalyze ...
24-178 7.55e-09

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK4 shows a restricted expression pattern and is usually found in epithelial cells. It is expressed in nephrons and in extrarenal tissues including intestine, eye, mammary glands, and prostate. WNK4 regulates a variety of ion transport proteins including apical or basolateral ion transporters, ion channels in the transcellular pathway, and claudins in the paracellular pathway. Mutations in WNK4 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension and hyperkalemia. WNK4 inhibits the activity of the thiazide-sensitive Na-Cl cotransporter (NCC), which is responsible for about 15% of NaCl reabsorption in the kidney. It also inhibits the renal outer medullary potassium channel (ROMK) and decreases its surface expression. Hypertension and hyperkalemia in PHAII patients with WNK4 mutations may be partly due to increased NaCl reabsorption through NCC and impaired renal potassium secretion by ROMK, respectively. The WNK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270935 [Multi-domain]  Cd Length: 261  Bit Score: 56.16  E-value: 7.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  24 ELEILQEIEHVFLVNLWYSFQD----EEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYL--RSQHIIH 97
Cdd:cd14033   50 EVEMLKGLQHPNIVRFYDSWKStvrgHKCIILVTELMTSGTLKTYLKRFREMKLKLLQRWSRQILKGLHFLhsRCPPILH 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  98 RDVKPDNILLD-EQGHAHLTDFNIATiIKDGERATALAGTKPYMAPEIFHSfvnggtGYSFEVDWWSVGVMAYELLRGWR 176
Cdd:cd14033  130 RDLKCDNIFITgPTGSVKIGDLGLAT-LKRASFAKSVIGTPEFMAPEMYEE------KYDEAVDVYAFGMCILEMATSEY 202

                 ..
gi 247269852 177 PY 178
Cdd:cd14033  203 PY 204
PTKc_HER2 cd05109
Catalytic domain of the Protein Tyrosine Kinase, HER2; PTKs catalyze the transfer of the ...
51-223 8.40e-09

Catalytic domain of the Protein Tyrosine Kinase, HER2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. HER2 (ErbB2, HER2/neu) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. HER2 does not bind to any known EGFR subfamily ligands, but contributes to the kinase activity of all possible heterodimers. It acts as the preferred partner of other ligand-bound EGFR proteins and functions as a signal amplifier, with the HER2-HER3 heterodimer being the most potent pair in mitogenic signaling. HER2 plays an important role in cell development, proliferation, survival and motility. Overexpression of HER2 results in its activation and downstream signaling, even in the absence of ligand. HER2 overexpression, mainly due to gene amplification, has been shown in a variety of human cancers. Its role in breast cancer is especially well-documented. HER2 is up-regulated in about 25% of breast tumors and is associated with increases in tumor aggressiveness, recurrence and mortality. HER2 is a target for monoclonal antibodies and small molecule inhibitors, which are being developed as treatments for cancer. The first humanized antibody approved for clinical use is Trastuzumab (Herceptin), which is being used in combination with other therapies to improve the survival rates of patients with HER2-overexpressing breast cancer. The HER2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270684 [Multi-domain]  Cd Length: 279  Bit Score: 56.19  E-value: 8.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  51 MVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC-EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGER 129
Cdd:cd05109   85 LVTQLMPYGCLLDYVRENKDRIGSQDLLNWCvQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDET 164
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 130 ATALAGTK---PYMAPE-IFHSfvnggtGYSFEVDWWSVGVMAYELLR-GWRPYDIHSSNAVESLVQLFSTVSVQyvPTW 204
Cdd:cd05109  165 EYHADGGKvpiKWMALEsILHR------RFTHQSDVWSYGVTVWELMTfGAKPYDGIPAREIPDLLEKGERLPQP--PIC 236
                        170
                 ....*....|....*....
gi 247269852 205 SKEMVALLRKLLTVNPEHR 223
Cdd:cd05109  237 TIDVYMIMVKCWMIDSECR 255
PKc_DYRK2_3 cd14224
Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and ...
71-175 8.62e-09

Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. This subfamily is composed of DYRK2 and DYRK3, and similar proteins. Drosophila DYRK2 interacts and phosphorylates the chromatin remodelling factor, SNR1 (Snf5-related 1), and also interacts with the essential chromatin component, trithorax. It may play a role in chromatin remodelling. Vertebrate DYRK2 phosphorylates and regulates the tumor suppressor p53 to induce apoptosis in response to DNA damage. It can also phosphorylate the transcription factor, nuclear factor of activated T cells (NFAT). DYRK2 is overexpressed in lung adenocarcinoma and esophageal carcinomas, and is a predictor for favorable prognosis in lung adenocarcinoma. DYRK3, also called regulatory erythroid kinase (REDK), is highly expressed in erythroid cells and the testis, and is also present in adult kidney and liver. It promotes cell survival by phosphorylating and activating SIRT1, an NAD(+)-dependent protein deacetylase, which promotes p53 deacetylation, resulting in the inhibition of apoptosis. DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. The DYRK2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other S/T kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271126 [Multi-domain]  Cd Length: 380  Bit Score: 56.68  E-value: 8.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  71 FSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHsfvn 150
Cdd:cd14224  165 FSLQLVRKFAHSILQCLDALHRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVIL---- 240
                         90       100
                 ....*....|....*....|....*
gi 247269852 151 gGTGYSFEVDWWSVGVMAYELLRGW 175
Cdd:cd14224  241 -GARYGMPIDMWSFGCILAELLTGY 264
PHA03207 PHA03207
serine/threonine kinase US3; Provisional
19-172 8.79e-09

serine/threonine kinase US3; Provisional


Pssm-ID: 165473 [Multi-domain]  Cd Length: 392  Bit Score: 56.78  E-value: 8.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  19 RNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQNVQFSEDTVrLYICEMAL-ALDYLRSQHIIH 97
Cdd:PHA03207 131 KTPGREIDILKTISHRAIINLIHAYRWKSTVCMVMPKY-KCDLFTYVDRSGPLPLEQA-ITIQRRLLeALAYLHGRGIIH 208
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852  98 RDVKPDNILLDEQGHAHLTDFNIA---TIIKDGERATALAGTKPYMAPEIFhsfvnGGTGYSFEVDWWSVGVMAYELL 172
Cdd:PHA03207 209 RDVKTENIFLDEPENAVLGDFGAAcklDAHPDTPQCYGWSGTLETNSPELL-----ALDPYCAKTDIWSAGLVLFEMS 281
PTKc_Abl cd05052
Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase; PTKs catalyze the transfer of ...
17-178 9.12e-09

Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Abl (or c-Abl) is a ubiquitously-expressed cytoplasmic (or nonreceptor) PTK that contains SH3, SH2, and tyr kinase domains in its N-terminal region, as well as nuclear localization motifs, a putative DNA-binding domain, and F- and G-actin binding domains in its C-terminal tail. It also contains a short autoinhibitory cap region in its N-terminus. Abl function depends on its subcellular localization. In the cytoplasm, Abl plays a role in cell proliferation and survival. In response to DNA damage or oxidative stress, Abl is transported to the nucleus where it induces apoptosis. In chronic myelogenous leukemia (CML) patients, an aberrant translocation results in the replacement of the first exon of Abl with the BCR (breakpoint cluster region) gene. The resulting BCR-Abl fusion protein is constitutively active and associates into tetramers, resulting in a hyperactive kinase sending a continuous signal. This leads to uncontrolled proliferation, morphological transformation and anti-apoptotic effects. BCR-Abl is the target of selective inhibitors, such as imatinib (Gleevec), used in the treatment of CML. Abl2, also known as ARG (Abelson-related gene), is thought to play a cooperative role with Abl in the proper development of the nervous system. The Tel-ARG fusion protein, resulting from reciprocal translocation between chromosomes 1 and 12, is associated with acute myeloid leukemia (AML). The TEL gene is a frequent fusion partner of other tyr kinase oncogenes, including Tel/Abl, Tel/PDGFRbeta, and Tel/Jak2, found in patients with leukemia and myeloproliferative disorders. The Abl subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270645 [Multi-domain]  Cd Length: 263  Bit Score: 55.89  E-value: 9.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  17 EVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRL-YIC-EMALALDYLRSQH 94
Cdd:cd05052   45 EVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMPYGNLLDYLRECNREELNAVVLlYMAtQIASAMEYLEKKN 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  95 IIHRDVKPDNILLDEQGHAHLTDFNIATIIKdGERATALAGTK---PYMAPE--IFHSFvnggtgySFEVDWWSVGVMAY 169
Cdd:cd05052  125 FIHRDLAARNCLVGENHLVKVADFGLSRLMT-GDTYTAHAGAKfpiKWTAPEslAYNKF-------SIKSDVWAFGVLLW 196
                        170
                 ....*....|
gi 247269852 170 ELLR-GWRPY 178
Cdd:cd05052  197 EIATyGMSPY 206
STKc_PINK1 cd14018
Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1; STKs catalyze ...
61-225 9.25e-09

Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PINK1 contains an N-terminal mitochondrial targeting sequence, a catalytic domain, and a C-terminal regulatory region. It plays an important role in maintaining mitochondrial homeostasis. It protects cells against oxidative stress-induced apoptosis by phosphorylating the chaperone TNFR-associated protein 1 (TRAP1), also called Hsp75. Phosphorylated TRAP1 prevents cytochrome c release and peroxide-induced apoptosis. PINK1 interacts with Omi/HtrA2, a serine protease, and Parkin, an E3 ubiquitin ligase, in different pathways to promote mitochondrial health. The parkin gene is the most commonly mutated gene in autosomal recessive familial parkinsonism. Mutations within the catalytic domain of PINK1 are also associated with Parkinson's disease. The PINK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270920 [Multi-domain]  Cd Length: 313  Bit Score: 55.96  E-value: 9.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  61 LRYHLQQNVQfSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAH----LTDFNIATIIKD-GERA----- 130
Cdd:cd14018  126 LRQYLWVNTP-SYRLARVMILQLLEGVDHLVRHGIAHRDLKSDNILLELDFDGCpwlvIADFGCCLADDSiGLQLpfssw 204
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 131 -TALAGTKPYMAPEIFHSFVNGGTGYSFE-VDWWSVGVMAYELLRGWRPYDIHSSNAVESlvqlfSTVSVQYVPTWSK-- 206
Cdd:cd14018  205 yVDRGGNACLMAPEVSTAVPGPGVVINYSkADAWAVGAIAYEIFGLSNPFYGLGDTMLES-----RSYQESQLPALPSav 279
                        170       180
                 ....*....|....*....|.
gi 247269852 207 --EMVALLRKLLTVNPEHRFS 225
Cdd:cd14018  280 ppDVRQVVKDLLQRDPNKRVS 300
STKc_RIP1 cd14027
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1; STKs catalyze ...
11-179 1.04e-08

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP1 harbors a C-terminal Death domain (DD), which binds death receptors (DRs) including TNF receptor 1, Fas, TNF-related apoptosis-inducing ligand receptor 1 (TRAILR1), and TRAILR2. It also interacts with other DD-containing adaptor proteins such as TRADD and FADD. RIP1 can also recruit other kinases including MEKK1, MEKK3, and RIP3 through an intermediate domain (ID) that bears a RIP homotypic interaction motif (RHIM). RIP1 plays a crucial role in determining a cell's fate, between survival or death, following exposure to stress signals. It is important in the signaling of NF-kappaB and MAPKs, and it links DR-associated signaling to reactive oxygen species (ROS) production. Abnormal RIP1 function may result in ROS accummulation affecting inflammatory responses, innate immunity, stress responses, and cell survival. RIP kinases serve as essential sensors of cellular stress. The RIP1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270929 [Multi-domain]  Cd Length: 267  Bit Score: 55.58  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  11 QCIERDEvrNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLrYHLQQNVQFSEDTVRLYICEMALALDYL 90
Cdd:cd14027   30 NCIEHNE--ALLEEGKMMNRLRHSRVVKLLGVILEEGKYSLVMEYMEKGNL-MHVLKKVSVPLSVKGRIILEIIEGMAYL 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  91 RSQHIIHRDVKPDNILLDEQGHAHLTDFNIAT------IIKDGER--------ATALAGTKPYMAPEIFHSFVNGGTGYS 156
Cdd:cd14027  107 HGKGVIHKDLKPENILVDNDFHIKIADLGLASfkmwskLTKEEHNeqrevdgtAKKNAGTLYYMAPEHLNDVNAKPTEKS 186
                        170       180
                 ....*....|....*....|...
gi 247269852 157 fevDWWSVGVMAYELLRGWRPYD 179
Cdd:cd14027  187 ---DVYSFAIVLWAIFANKEPYE 206
PTKc_Chk cd05083
Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase; PTKs catalyze the ...
19-191 1.16e-08

Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Chk is also referred to as megakaryocyte-associated tyrosine kinase (Matk). Chk inhibits Src kinases using a noncatalytic mechanism by simply binding to them. As a negative regulator of Src kinases, Chk may play important roles in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. Chk is expressed in brain and hematopoietic cells. Like Csk, it is a cytoplasmic (or nonreceptor) tyr kinase containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. To inhibit Src kinases that are anchored to the plasma membrane, Chk is translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. Studies in mice reveal that Chk is not functionally redundant with Csk and that it plays an important role as a regulator of immune responses. Chk also plays a role in neural differentiation in a manner independent of Src by enhancing Mapk activation via Ras-mediated signaling. The Chk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270666 [Multi-domain]  Cd Length: 254  Bit Score: 55.26  E-value: 1.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  19 RNVFRELEILQEIEHVFLVNLwYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALA--LDYLRSQHII 96
Cdd:cd05083   44 QAFLEETAVMTKLQHKNLVRL-LGVILHNGLYIVMELMSKGNLVNFLRSRGRALVPVIQLLQFSLDVAegMEYLESKKLV 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  97 HRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAgtKPYMAPEIFHSFvnggtGYSFEVDWWSVGVMAYELLR-GW 175
Cdd:cd05083  123 HRDLAARNILVSEDGVAKISDFGLAKVGSMGVDNSRLP--VKWTAPEALKNK-----KFSSKSDVWSYGVLLWEVFSyGR 195
                        170
                 ....*....|....*.
gi 247269852 176 RPYDIHSSNAVESLVQ 191
Cdd:cd05083  196 APYPKMSVKEVKEAVE 211
PTKc_FGFR3 cd05100
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3; PTKs ...
7-178 1.51e-08

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Many FGFR3 splice variants have been reported with the IIIb and IIIc isoforms being the predominant forms. FGFR3 IIIc is the isoform expressed in chondrocytes, the cells affected in dwarfism, while IIIb is expressed in epithelial cells. FGFR3 ligands include FGF1, FGF2, FGF4, FGF8, FGF9, and FGF23. It is a negative regulator of long bone growth. In the cochlear duct and in the lens, FGFR3 is involved in differentiation while it appears to have a role in cell proliferation in epithelial cells. Germline mutations in FGFR3 are associated with skeletal disorders including several forms of dwarfism. Some missense mutations are associated with multiple myeloma and carcinomas of the bladder and cervix. Overexpression of FGFR3 is found in thyroid carcinoma. FGFR3 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173652 [Multi-domain]  Cd Length: 334  Bit Score: 55.80  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   7 MNKQQCIERDeVRNVFRELEILQEI-EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQN----VQFSEDTVR---- 77
Cdd:cd05100   51 MLKDDATDKD-LSDLVSEMEMMKMIgKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARrppgMDYSFDTCKlpee 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  78 ------LYIC--EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIK--DGERATAlAGTKP--YMAPEIF 145
Cdd:cd05100  130 qltfkdLVSCayQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHniDYYKKTT-NGRLPvkWMAPEAL 208
                        170       180       190
                 ....*....|....*....|....*....|....
gi 247269852 146 HSFVnggtgYSFEVDWWSVGVMAYELLR-GWRPY 178
Cdd:cd05100  209 FDRV-----YTHQSDVWSFGVLLWEIFTlGGSPY 237
BREX_PglW NF033442
BREX system serine/threonine kinase PglW; Members of this family are PglW, a predicted serine ...
86-233 1.55e-08

BREX system serine/threonine kinase PglW; Members of this family are PglW, a predicted serine/threonine kinase of the Pgl (phage growth limitation) system (now called BREX type 2) and the BREX type 3 system.


Pssm-ID: 468028 [Multi-domain]  Cd Length: 1387  Bit Score: 56.50  E-value: 1.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   86 ALDYLRSQHIIHRDVKPDNILLDEQG----HAHLTDFNIAtiiKDGERATAlAGTKPYMAPeifhsFVNGGT--GYSFEV 159
Cdd:NF033442  619 AVVHLEGQGVWHRDIKPDNIGIRPRPsrtlHLVLFDFSLA---GAPADNIE-AGTPGYLDP-----FLGTGTrpRYDDAA 689
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852  160 DWWSVGVMAYELLRGWRP-YDIHSSNA--VESLVQLFSTVsvqYVPTWSKEMVALLRKLLTVNPEHRFSSLQDMQTA 233
Cdd:NF033442  690 ERYAAAVTLYEMATGTLPvWGDGQVDPatLDDEVTLDAEA---FDPAVRDGLVAFFRRALARDARDRFDTAEDMRRA 763
PHA03211 PHA03211
serine/threonine kinase US3; Provisional
86-170 1.61e-08

serine/threonine kinase US3; Provisional


Pssm-ID: 223009 [Multi-domain]  Cd Length: 461  Bit Score: 56.05  E-value: 1.61e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  86 ALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKdGERAT----ALAGTKPYMAPEIFhsfvnGGTGYSFEVDW 161
Cdd:PHA03211 272 AIDYIHGEGIIHRDIKTENVLVNGPEDICLGDFGAACFAR-GSWSTpfhyGIAGTVDTNAPEVL-----AGDPYTPSVDI 345

                 ....*....
gi 247269852 162 WSVGVMAYE 170
Cdd:PHA03211 346 WSAGLVIFE 354
STKc_IRE1 cd13982
Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1; STKs catalyze ...
22-240 1.81e-08

Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRE1, also called Endoplasmic reticulum (ER)-to-nucleus signaling protein (or ERN), is an ER-localized type I transmembrane protein with kinase and endoribonuclease domains in the cytoplasmic side. It acts as an ER stress sensor and is the oldest and most conserved component of the unfolded protein response (UPR) in eukaryotes. The UPR is activated when protein misfolding is detected in the ER in order to decrease the synthesis of new proteins and increase the capacity of the ER to cope with the stress. During ER stress, IRE1 dimerizes and forms oligomers, allowing the kinase domain to undergo trans-autophosphorylation. This leads to a conformational change that stimulates its endoribonuclease activity and results in the cleavage of its mRNA substrate, HAC1 in yeast and XBP1 in metazoans, promoting a splicing event that enables translation into a transcription factor which activates the UPR. Mammals contain two IRE1 proteins, IRE1alpha (or ERN1) and IRE1beta (or ERN2). The Ire1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270884 [Multi-domain]  Cd Length: 269  Bit Score: 54.97  E-value: 1.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  22 FRELEILQEI-EHVFLVNLWYSFQDEEDMFMVV--------DLLLGGDLRYHLQQNvqfSEDTVRLyICEMALALDYLRS 92
Cdd:cd13982   42 DREVQLLRESdEHPNVIRYFCTEKDRQFLYIALelcaaslqDLVESPRESKLFLRP---GLEPVRL-LRQIASGLAHLHS 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILLD-----EQGHAHLTDFNIATIIKDGE----RATALAGTKPYMAPEIFHSFVNGGTGYSfeVDWWS 163
Cdd:cd13982  118 LNIVHRDLKPQNILIStpnahGNVRAMISDFGLCKKLDVGRssfsRRSGVAGTSGWIAPEMLSGSTKRRQTRA--VDIFS 195
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247269852 164 VG-VMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRfsslqdmqtaPSLAHVL 240
Cdd:cd13982  196 LGcVFYYVLSGGSHPFGDKLEREANILKGKYSLDKLLSLGEHGPEAQDLIERMIDFDPEKR----------PSAEEVL 263
PTKc_Hck cd05073
Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase; PTKs catalyze the ...
18-230 1.84e-08

Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Hck is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Hck is present in myeloid and lymphoid cells that play a role in the development of cancer. It may be important in the oncogenic signaling of the protein Tel-Abl, which induces a chronic myelogenous leukemia (CML)-like disease. Hck also acts as a negative regulator of G-CSF-induced proliferation of granulocytic precursors, suggesting a possible role in the development of acute myeloid leukemia (AML). In addition, Hck is essential in regulating the degranulation of polymorphonuclear leukocytes. Genetic polymorphisms affect the expression level of Hck, which affects PMN mediator release and influences the development of chronic obstructive pulmonary disease (COPD). Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Hck subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270658 [Multi-domain]  Cd Length: 265  Bit Score: 55.03  E-value: 1.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  18 VRNVFRELEILQEIEHVFLVNLwYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRL--YICEMALALDYLRSQHI 95
Cdd:cd05073   50 VEAFLAEANVMKTLQHDKLVKL-HAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLidFSAQIAEGMAFIEQRNY 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  96 IHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERaTALAGTK---PYMAPEIfhsfVNGGTgYSFEVDWWSVGVMAYELL 172
Cdd:cd05073  129 IHRDLRAANILVSASLVCKIADFGLARVIEDNEY-TAREGAKfpiKWTAPEA----INFGS-FTIKSDVWSFGILLMEIV 202
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 247269852 173 R-GWRPY-DIHSSNAVESLVQLFSTVSVQYVPtwsKEMVALLRKLLTVNPEHR--FSSLQDM 230
Cdd:cd05073  203 TyGRIPYpGMSNPEVIRALERGYRMPRPENCP---EELYNIMMRCWKNRPEERptFEYIQSV 261
PTKc_PDGFR cd05055
Catalytic domain of the Protein Tyrosine Kinases, Platelet Derived Growth Factor Receptors; ...
15-228 1.87e-08

Catalytic domain of the Protein Tyrosine Kinases, Platelet Derived Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The PDGFR subfamily consists of PDGFR alpha, PDGFR beta, KIT, CSF-1R, the mammalian FLT3, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. PDGFR kinase domains are autoinhibited by their juxtamembrane regions containing tyr residues. The binding to their ligands leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR subfamily receptors are important in the development of a variety of cells. PDGFRs are expressed in a many cells including fibroblasts, neurons, endometrial cells, mammary epithelial cells, and vascular smooth muscle cells. PDGFR signaling is critical in normal embryonic development, angiogenesis, and wound healing. Kit is important in the development of melanocytes, germ cells, mast cells, hematopoietic stem cells, the interstitial cells of Cajal, and the pacemaker cells of the GI tract. CSF-1R signaling is critical in the regulation of macrophages and osteoclasts. Mammalian FLT3 plays an important role in the survival, proliferation, and differentiation of stem cells. The PDGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase .


Pssm-ID: 133186 [Multi-domain]  Cd Length: 302  Bit Score: 55.18  E-value: 1.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  15 RDEVRNVFRELEILQEI-EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRL--YICEMALALDYLR 91
Cdd:cd05055   79 SSEREALMSELKIMSHLgNHENIVNLLGACTIGGPILVITEYCCYGDLLNFLRRKRESFLTLEDLlsFSYQVAKGMAFLA 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  92 SQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTK---PYMAPE-IFHSFvnggtgYSFEVDWWSVGVM 167
Cdd:cd05055  159 SKNCIHRDLAARNVLLTHGKIVKICDFGLARDIMNDSNYVVKGNARlpvKWMAPEsIFNCV------YTFESDVWSYGIL 232
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 247269852 168 AYELLR-GWRPY-DIHSSNAVESLVQL-FSTVSVQYVPtwsKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd05055  233 LWEIFSlGSNPYpGMPVDSKFYKLIKEgYRMAQPEHAP---AEIYDIMKTCWDADPLKRPTFKQ 293
PTKc_FGFR4 cd05099
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4; PTKs ...
7-178 1.90e-08

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Unlike other FGFRs, there is only one splice form of FGFR4. It binds FGF1, FGF2, FGF6, FGF19, and FGF23. FGF19 is a selective ligand for FGFR4. Although disruption of FGFR4 in mice causes no obvious phenotype, in vivo inhibition of FGFR4 in cultured skeletal muscle cells resulted in an arrest of muscle progenitor differentiation. FGF6 and FGFR4 are uniquely expressed in myofibers and satellite cells. FGF6/FGFR4 signaling appears to play a key role in the regulation of muscle regeneration. A polymorphism in FGFR4 is found in head and neck squamous cell carcinoma. FGFR4 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR4 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133230 [Multi-domain]  Cd Length: 314  Bit Score: 55.36  E-value: 1.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   7 MNKQQCIERDeVRNVFRELEILQEI-EHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ----NVQFSEDTVR---- 77
Cdd:cd05099   51 MLKDNATDKD-LADLISEMELMKLIgKHKNIINLLGVCTQEGPLYVIVEYAAKGNLREFLRArrppGPDYTFDITKvpee 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  78 ------LYIC--EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALA-GTKP--YMAPEIFH 146
Cdd:cd05099  130 qlsfkdLVSCayQVARGMEYLESRRCIHRDLAARNVLVTEDNVMKIADFGLARGVHDIDYYKKTSnGRLPvkWMAPEALF 209
                        170       180       190
                 ....*....|....*....|....*....|...
gi 247269852 147 SFVnggtgYSFEVDWWSVGVMAYELLR-GWRPY 178
Cdd:cd05099  210 DRV-----YTHQSDVWSFGILMWEIFTlGGSPY 237
STKc_TGFbR-like cd13998
Catalytic domain of Transforming Growth Factor beta Receptor-like Serine/Threonine Kinases; ...
17-173 2.35e-08

Catalytic domain of Transforming Growth Factor beta Receptor-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of receptors for the TGFbeta family of secreted signaling molecules including TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. There are two types of TGFbeta receptors included in this subfamily, I and II, that play different roles in signaling. For signaling to occur, the ligand first binds to the high-affinity type II receptor, which is followed by the recruitment of the low-affinity type I receptor to the complex and its activation through trans-phosphorylation by the type II receptor. The active type I receptor kinase starts intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. Different ligands interact with various combinations of types I and II receptors to elicit a specific signaling pathway. Activins primarily signal through combinations of ACVR1b/ALK7 and ACVR2a/b; myostatin and GDF11 through TGFbR1/ALK4 and ACVR2a/b; BMPs through ACVR1/ALK1 and BMPR2; and TGFbeta through TGFbR1 and TGFbR2. The TGFbR-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270900 [Multi-domain]  Cd Length: 289  Bit Score: 54.75  E-value: 2.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  17 EVRNVFRELEILQE--IEHVFLVNLWYSfqDEEDMFMVVDLLL------GGDLRYHLQQNVQFSEDTVRLyICEMALALD 88
Cdd:cd13998   30 DKQSWFREKEIYRTpmLKHENILQFIAA--DERDTALRTELWLvtafhpNGSL*DYLSLHTIDWVSLCRL-ALSVARGLA 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  89 YLRSQH---------IIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALA-----GTKPYMAPEIFHSFVNGGTG 154
Cdd:cd13998  107 HLHSEIpgctqgkpaIAHRDLKSKNILVKNDGTCCIADFGLAVRLSPSTGEEDNAnngqvGTKRYMAPEVLEGAINLRDF 186
                        170       180
                 ....*....|....*....|
gi 247269852 155 YSF-EVDWWSVGVMAYELLR 173
Cdd:cd13998  187 ESFkRVDIYAMGLVLWEMAS 206
STKc_HIPK3 cd14229
Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3; ...
36-178 2.61e-08

Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HIPK3 is a Fas-interacting protein that induces FADD (Fas-associated death domain) phosphorylation and mediates FasL-induced JNK activation. Overexpression of HIPK3 does not affect cell death, however its expression in prostate cancer cells contributes to increased resistance to Fas receptor-mediated apoptosis. HIPK3 also plays a role in regulating steroidogenic gene expression. In response to cAMP, HIPK3 activates the phosphorylation of JNK and c-Jun, leading to increased activity of the transcription factor SF-1 (Steroidogenic factor 1), a key regulator for steroid biosynthesis in the gonad and adrenal gland. HIPKs, originally identified by their ability to bind homeobox factors, are nuclear proteins containing catalytic kinase and homeobox-interacting domains as well as a PEST region overlapping with the speckle-retention signal (SRS). The HIPK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 271131 [Multi-domain]  Cd Length: 330  Bit Score: 55.03  E-value: 2.61e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  36 LVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQNvQFSE---DTVRLYICEMALALDYLRSQHIIHRDVKPDNILL----D 108
Cdd:cd14229   63 FVRAYECFQHRNHTCLVFEML-EQNLYDFLKQN-KFSPlplKVIRPILQQVATALKKLKSLGLIHADLKPENIMLvdpvR 140
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 109 EQGHAHLTDFNIATIIKDGERATALAgTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd14229  141 QPYRVKVIDFGSASHVSKTVCSTYLQ-SRYYRAPEIIL-----GLPFCEAIDMWSLGCVIAELFLGWPLY 204
PHA03212 PHA03212
serine/threonine kinase US3; Provisional
74-174 2.62e-08

serine/threonine kinase US3; Provisional


Pssm-ID: 165478 [Multi-domain]  Cd Length: 391  Bit Score: 55.00  E-value: 2.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  74 DTVRLYICEMAL-------ALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKD--GERATALAGTKPYMAPEI 144
Cdd:PHA03212 175 AKRNIAICDILAiersvlrAIQYLHENRIIHRDIKAENIFINHPGDVCLGDFGAACFPVDinANKYYGWAGTIATNAPEL 254
                         90       100       110
                 ....*....|....*....|....*....|
gi 247269852 145 FhsfvnGGTGYSFEVDWWSVGVMAYELLRG 174
Cdd:PHA03212 255 L-----ARDPYGPAVDIWSAGIVLFEMATC 279
PKc_like cd13968
Catalytic domain of the Protein Kinase superfamily; The PK superfamily contains the large ...
2-118 3.19e-08

Catalytic domain of the Protein Kinase superfamily; The PK superfamily contains the large family of typical PKs that includes serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins, as well as pseudokinases that lack crucial residues for catalytic activity and/or ATP binding. It also includes phosphoinositide 3-kinases (PI3Ks), aminoglycoside 3'-phosphotransferases (APHs), choline kinase (ChoK), Actin-Fragmin Kinase (AFK), and the atypical RIO and Abc1p-like protein kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to their target substrates; these include serine/threonine/tyrosine residues in proteins for typical or atypical PKs, the 3-hydroxyl of the inositol ring of D-myo-phosphatidylinositol (PtdIns) or its derivatives for PI3Ks, the 4-hydroxyl of PtdIns for PI4Ks, and other small molecule substrates for APH/ChoK and similar proteins such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine.


Pssm-ID: 270870 [Multi-domain]  Cd Length: 136  Bit Score: 52.06  E-value: 3.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYMNKQQCIERDEVRNvfrELEILQEIE-HVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI 80
Cdd:cd13968   21 VAVKIGDDVNNEEGEDLES---EMDILRRLKgLELNIPKVLVTEDVDGPNILLMELVKGGTLIAYTQEEELDEKDVESIM 97
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 247269852  81 CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDF 118
Cdd:cd13968   98 YQLAECMRLLHSFHLIHRDLNNDNILLSEDGNVKLIDF 135
PHA03209 PHA03209
serine/threonine kinase US3; Provisional
87-172 3.26e-08

serine/threonine kinase US3; Provisional


Pssm-ID: 177557 [Multi-domain]  Cd Length: 357  Bit Score: 54.88  E-value: 3.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  87 LDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFhsfvnGGTGYSFEVDWWSVGV 166
Cdd:PHA03209 170 LRYLHAQRIIHRDVKTENIFINDVDQVCIGDLGAAQFPVVAPAFLGLAGTVETNAPEVL-----ARDKYNSKADIWSAGI 244

                 ....*.
gi 247269852 167 MAYELL 172
Cdd:PHA03209 245 VLFEML 250
STKc_WNK2_like cd14032
Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases; STKs catalyze the ...
24-224 3.35e-08

Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK2 is widely expressed and has been shown to be epigenetically silenced in gliomas. It inhibits cell growth by acting as a negative regulator of MEK1-ERK1/2 signaling. WNK2 modulates growth factor-induced cancer cell proliferation, suggesting that it may be a tumor suppressor gene. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. They are critical in regulating ion balance and are thus, important components in the control of blood pressure. The WNK2-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270934 [Multi-domain]  Cd Length: 266  Bit Score: 53.93  E-value: 3.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  24 ELEILQEIEH---VFLVNLW-YSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYL--RSQHIIH 97
Cdd:cd14032   50 EAEMLKGLQHpniVRFYDFWeSCAKGKRCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLLFLhtRTPPIIH 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  98 RDVKPDNILLD-EQGHAHLTDFNIATiIKDGERATALAGTKPYMAPEIFHSFvnggtgYSFEVDWWSVGVMAYELLRGWR 176
Cdd:cd14032  130 RDLKCDNIFITgPTGSVKIGDLGLAT-LKRASFAKSVIGTPEFMAPEMYEEH------YDESVDVYAFGMCMLEMATSEY 202
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 247269852 177 PYdihssNAVESLVQLFSTVSVQYVP-TWSK----EMVALLRKLLTVNPEHRF 224
Cdd:cd14032  203 PY-----SECQNAAQIYRKVTCGIKPaSFEKvtdpEIKEIIGECICKNKEERY 250
PKc_Dusty cd13975
Catalytic domain of the Dual-specificity Protein Kinase, Dusty; Dual-specificity PKs catalyze ...
83-174 3.53e-08

Catalytic domain of the Dual-specificity Protein Kinase, Dusty; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. Dusty protein kinase is also called Receptor-interacting protein kinase 5 (RIPK5 or RIP5) or RIP-homologous kinase. It is widely distributed in the central nervous system, and may be involved in inducing both caspase-dependent and caspase-independent cell death. The Dusty subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270877 [Multi-domain]  Cd Length: 262  Bit Score: 54.03  E-value: 3.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALD------YLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAtiIKDGERATALAGTKPYMAPEIFhsfvnggTG-Y 155
Cdd:cd13975  105 LQIALDvvegirFLHSQGLVHRDIKLKNVLLDKKNRAKITDLGFC--KPEAMMSGSIVGTPIHMAPELF-------SGkY 175
                         90
                 ....*....|....*....
gi 247269852 156 SFEVDWWSVGVMAYELLRG 174
Cdd:cd13975  176 DNSVDVYAFGILFWYLCAG 194
PKc_CLK3 cd14214
Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 3; Dual-specificity ...
18-192 4.85e-08

Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 3; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. CLK3 is predominantly expressed in mature spermatozoa, and might play a role in the fertilization process. CLKs are involved in the phosphorylation and regulation of serine/arginine-rich (SR) proteins, which play a crucial role in pre-mRNA splicing by directing splice site selection. SR proteins are phosphorylated first by SR protein kinases (SRPKs) at the N-terminus, which leads to its assembly into nuclear speckles where splicing factors are stored. CLKs phosphorylate the C-terminal part of SR proteins, causing the nuclear speckles to dissolve and splicing factors to be recruited at sites of active transcription. Based on a conserved "EHLAMMERILG" signature motif which may be crucial for substrate specificity, CLKs are also referred to as LAMMER kinases. CLKs autophosphorylate at tyrosine residues and phosphorylate their substrates exclusively on serine/threonine residues. The CLK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271116 [Multi-domain]  Cd Length: 331  Bit Score: 54.25  E-value: 4.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  18 VRNV--FRE---LEI--LQEI-----EHVFLVNL---WYSFQDEedMFMVVDLLLGGDLRYHLQQNVQ-FSEDTVRLYIC 81
Cdd:cd14214   47 IRNVgkYREaarLEInvLKKIkekdkENKFLCVLmsdWFNFHGH--MCIAFELLGKNTFEFLKENNFQpYPLPHIRHMAY 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLD--------------EQGHA-----HLTDFNIATIikDGERATALAGTKPYMAP 142
Cdd:cd14214  125 QLCHALKFLHENQLTHTDLKPENILFVnsefdtlyneskscEEKSVkntsiRVADFGSATF--DHEHHTTIVATRHYRPP 202
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 247269852 143 EIFHSFvnggtGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNavESLVQL 192
Cdd:cd14214  203 EVILEL-----GWAQPCDVWSLGCILFEYYRGFTLFQTHENR--EHLVMM 245
STKc_MAP3K8 cd13995
Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) ...
87-226 5.01e-08

Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP3K8 is also called Tumor progression locus 2 (Tpl2) or Cancer Osaka thyroid (Cot), and was first identified as a proto-oncogene in T-cell lymphoma induced by MoMuL virus and in breast carcinoma induced by MMTV. Activated MAP3K8 induces various MAPK pathways including Extracellular Regulated Kinase (ERK) 1/2, c-Jun N-terminal kinase (JNK), and p38. It plays a pivotal role in innate immunity, linking Toll-like receptors to the production of TNF and the activation of ERK in macrophages. It is also required in interleukin-1beta production and is critical in host defense against Gram-positive bacteria. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The MAP3K8 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270897 [Multi-domain]  Cd Length: 256  Bit Score: 53.47  E-value: 5.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  87 LDYLRSQHIIHRDVKPDNILLdEQGHAHLTDFNIATIIKDGERATA-LAGTKPYMAPEIFHSfvnggTGYSFEVDWWSVG 165
Cdd:cd13995  109 LDFLHSKNIIHHDIKPSNIVF-MSTKAVLVDFGLSVQMTEDVYVPKdLRGTEIYMSPEVILC-----RGHNTKADIYSLG 182
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 247269852 166 VMAYELLRGWRPY-DIHSSNAVESLVQLFSTVS--VQYVP-TWSKEMVALLRKLLTVNPEHRFSS 226
Cdd:cd13995  183 ATIIHMQTGSPPWvRRYPRSAYPSYLYIIHKQAppLEDIAqDCSPAMRELLEAALERNPNHRSSA 247
PTKc_HER4 cd05110
Catalytic domain of the Protein Tyrosine Kinase, HER4; PTKs catalyze the transfer of the ...
79-179 5.20e-08

Catalytic domain of the Protein Tyrosine Kinase, HER4; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. HER4 (ErbB4) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Ligands that bind HER4 fall into two groups, the neuregulins (or heregulins) and some EGFR (HER1) ligands including betacellulin, HBEGF, and epiregulin. All four neuregulins (NRG1-4) interact with HER4. Upon ligand binding, HER4 forms homo- or heterodimers with other HER proteins. HER4 is essential in embryonic development. It is implicated in mammary gland, cardiac, and neural development. As a postsynaptic receptor of NRG1, HER4 plays an important role in synaptic plasticity and maturation. The impairment of NRG1/HER4 signaling may contribute to schizophrenia. The HER4 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173655 [Multi-domain]  Cd Length: 303  Bit Score: 53.92  E-value: 5.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTK---PYMAPEIFHSfvnggTGY 155
Cdd:cd05110  114 WCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKmpiKWMALECIHY-----RKF 188
                         90       100
                 ....*....|....*....|....*
gi 247269852 156 SFEVDWWSVGVMAYELLR-GWRPYD 179
Cdd:cd05110  189 THQSDVWSYGVTIWELMTfGGKPYD 213
PKc_YAK1 cd14212
Catalytic domain of the Dual-specificity protein kinase, YAK1; Dual-specificity PKs catalyze ...
56-174 5.77e-08

Catalytic domain of the Dual-specificity protein kinase, YAK1; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. This subfamily is composed of proteins with similarity to Saccharomyces cerevisiae YAK1 (or Yak1p), a dual-specificity kinase that autophosphorylates at tyrosine residues and phosphorylates substrates on S/T residues. YAK1 phosphorylates and activates the transcription factors Hsf1 and Msn2, which play important roles in cellular homeostasis during stress conditions including heat shock, oxidative stress, and nutrient deficiency. It also phosphorylates the protein POP2, a component of a complex that regulates transcription, under glucose-deprived conditions. It functions as a part of a glucose-sensing system that is involved in controlling growth in yeast. The YAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271114 [Multi-domain]  Cd Length: 330  Bit Score: 53.79  E-value: 5.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  56 LLGGDLrYHLQQNVQF---SEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAH--LTDFNIATIikdgERA 130
Cdd:cd14212   83 LLGVNL-YELLKQNQFrglSLQLIRKFLQQLLDALSVLKDARIIHCDLKPENILLVNLDSPEikLIDFGSACF----ENY 157
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 247269852 131 TALA--GTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLRG 174
Cdd:cd14212  158 TLYTyiQSRFYRSPEVLL-----GLPYSTAIDMWSLGCIAAELFLG 198
STKc_GAK cd14036
Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase; STKs ...
60-225 6.82e-08

Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GAK, also called auxilin-2, contains an N-terminal kinase domain that phosphorylates the mu subunits of adaptor protein (AP) 1 and AP2. In addition, it contains an auxilin-1-like domain structure consisting of PTEN-like, clathrin-binding, and J domains. Like auxilin-1, GAK facilitates Hsc70-mediated dissociation of clathrin from clathrin-coated vesicles. GAK is expressed ubiquitously and is enriched in the Golgi, unlike auxilin-1 which is nerve-specific. GAK also plays regulatory roles outside of clathrin-mediated membrane traffic including the maintenance of centrosome integrity and chromosome congression, neural patterning, survival of neurons, and immune responses through interaction with the interleukin 12 receptor. It also interacts with the androgen receptor, acting as a transcriptional coactivator, and its expression is significantly increased with the progression of prostate cancer. The GAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270938 [Multi-domain]  Cd Length: 282  Bit Score: 53.28  E-value: 6.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  60 DLRYHLQQNVQFSEDTVRLYICEMALALDYLRSQH--IIHRDVKPDNILLDEQGHAHLTDFNIATII--------KDGER 129
Cdd:cd14036   94 DFVKKVEAPGPFSPDTVLKIFYQTCRAVQHMHKQSppIIHRDLKIENLLIGNQGQIKLCDFGSATTEahypdyswSAQKR 173
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 130 ATA----LAGTKP-YMAPEIFHSFVNGGTGYsfEVDWWSVGVMAYELLRGWRPYDIHSSNAVeslvqLFSTVSVQYVPTW 204
Cdd:cd14036  174 SLVedeiTRNTTPmYRTPEMIDLYSNYPIGE--KQDIWALGCILYLLCFRKHPFEDGAKLRI-----INAKYTIPPNDTQ 246
                        170       180
                 ....*....|....*....|.
gi 247269852 205 SKEMVALLRKLLTVNPEHRFS 225
Cdd:cd14036  247 YTVFHDLIRSTLKVNPEERLS 267
STKc_RIP2 cd14026
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2; STKs catalyze ...
3-228 7.18e-08

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP2, also called RICK or CARDIAK, harbors a C-terminal Caspase Activation and Recruitment domain (CARD) belonging to the Death domain (DD) superfamily. It functions as an effector kinase downstream of the pattern recognition receptors from the Nod-like (NLR) family, Nod1 and Nod2, which recognizes bacterial peptidoglycans released upon infection. RIP2 may also be involved in regulating wound healing and keratinocyte proliferation. RIP kinases serve as essential sensors of cellular stress. The RIP2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270928 [Multi-domain]  Cd Length: 284  Bit Score: 53.38  E-value: 7.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDT--VRLYI 80
Cdd:cd14026   26 AIKCLKLDSPVGDSERNCLLKEAEILHKARFSYILPILGICNEPEFLGIVTEYMTNGSLNELLHEKDIYPDVAwpLRLRI 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 C-EMALALDYLRSQH--IIHRDVKPDNILLDEQGHAHLTDFNIA-----TIIKD-GERATALAGTKPYMAPEIFHSfvNG 151
Cdd:cd14026  106 LyEIALGVNYLHNMSppLLHHDLKTQNILLDGEFHVKIADFGLSkwrqlSISQSrSSKSAPEGGTIIYMPPEEYEP--SQ 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 152 GTGYSFEVDWWSVGVMAYELLRGWRPYDihssnAVESLVQLFSTVSVQYVPTWSKE-----------MVALLRKLLTVNP 220
Cdd:cd14026  184 KRRASVKHDIYSYAIIMWEVLSRKIPFE-----EVTNPLQIMYSVSQGHRPDTGEDslpvdiphratLINLIESGWAQNP 258

                 ....*...
gi 247269852 221 EHRFSSLQ 228
Cdd:cd14026  259 DERPSFLK 266
PTKc_Csk cd05082
Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase; PTKs catalyze the ...
11-178 7.87e-08

Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Csk catalyzes the tyr phosphorylation of the regulatory C-terminal tail of Src kinases, resulting in their inactivation. Csk is expressed in a wide variety of tissues. As a negative regulator of Src, Csk plays a role in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. Csk is a cytoplasmic (or nonreceptor) PTK containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. To inhibit Src kinases, Csk is translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. In addition, Csk also shows Src-independent functions. It is a critical component in G-protein signaling, and plays a role in cytoskeletal reorganization and cell migration. The Csk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133213 [Multi-domain]  Cd Length: 256  Bit Score: 52.68  E-value: 7.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  11 QCIERDEVRNVF-RELEILQEIEHVFLVNLW-YSFQDEEDMFMVVDLLLGGDLRYHLQQN----------VQFSEDtvrl 78
Cdd:cd05082   35 KCIKNDATAQAFlAEASVMTQLRHSNLVQLLgVIVEEKGGLYIVTEYMAKGSLVDYLRSRgrsvlggdclLKFSLD---- 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 yICEmalALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNI---ATIIKDgeraTALAGTKpYMAPEIFHSfvnggTGY 155
Cdd:cd05082  111 -VCE---AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLtkeASSTQD----TGKLPVK-WTAPEALRE-----KKF 176
                        170       180
                 ....*....|....*....|....
gi 247269852 156 SFEVDWWSVGVMAYELLR-GWRPY 178
Cdd:cd05082  177 STKSDVWSFGILLWEIYSfGRVPY 200
PTKc_VEGFR1 cd14207
Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; ...
73-178 7.98e-08

Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR1 (or Flt1) binds VEGFA, VEGFB, and placenta growth factor (PLGF). It regulates monocyte and macrophage migration, vascular permeability, haematopoiesis, and the recruitment of haematopietic progenitor cells from the bone marrow. VEGFR1 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271109 [Multi-domain]  Cd Length: 340  Bit Score: 53.47  E-value: 7.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  73 EDTVRlYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIA-TIIKDGERATALAGTKP--YMAPE-IFHSF 148
Cdd:cd14207  180 EDLIS-YSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLArDIYKNPDYVRKGDARLPlkWMAPEsIFDKI 258
                         90       100       110
                 ....*....|....*....|....*....|.
gi 247269852 149 vnggtgYSFEVDWWSVGVMAYELLR-GWRPY 178
Cdd:cd14207  259 ------YSTKSDVWSYGVLLWEIFSlGASPY 283
PTKc_VEGFR2 cd05103
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2; ...
79-178 8.41e-08

Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR2 (or Flk1) binds the ligands VEGFA, VEGFC, VEGFD and VEGFE. VEGFR2 signaling is implicated in all aspects of normal and pathological vascular endothelial cell biology. It induces a variety of cellular effects including migration, survival, and proliferation. It is critical in regulating embryonic vascular development and angiogenesis. VEGFR2 is the major signal transducer in pathological angiogenesis including cancer and diabetic retinopathy, and is a target for inhibition in cancer therapy. The carboxyl terminus of VEGFR2 plays an important role in its autophosphorylation and activation. VEGFR2 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270681 [Multi-domain]  Cd Length: 343  Bit Score: 53.45  E-value: 8.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIA-TIIKDGERATALAGTKP--YMAPEIFHSFVnggtgY 155
Cdd:cd05103  184 YSFQVAKGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLArDIYKDPDYVRKGDARLPlkWMAPETIFDRV-----Y 258
                         90       100
                 ....*....|....*....|....
gi 247269852 156 SFEVDWWSVGVMAYELLR-GWRPY 178
Cdd:cd05103  259 TIQSDVWSFGVLLWEIFSlGASPY 282
STKc_WNK1 cd14030
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1; STKs catalyze ...
13-178 8.71e-08

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK1 is widely expressed and is most abundant in the testis. In hyperosmotic or hypotonic low-chloride stress conditions, WNK1 is activated and it phosphorylates its substrates including SPAK and OSR1 kinases, which regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. Mutations in WNK1 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension and hyperkalemia. WNK1 negates WNK4-mediated inhibition of the sodium-chloride cotransporter NCC and activates the epithelial sodium channel ENaC by activating SGK1. WNK1 also decreases the surface expression of renal outer medullary potassium channel (ROMK) by stimulating their endocytosis. Hypertension and hyperkalemia in PHAII patients with WNK1 mutations may be due partly to increased activity of NCC and ENaC, and impaired renal potassium secretion by ROMK, respectively. In addition, WNK1 interacts with MEKK2/3 and acts as an activator of extracellular signal-regulated kinase (ERK) 5. It also negatively regulates TGFbeta signaling. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. The WNK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270932 [Multi-domain]  Cd Length: 289  Bit Score: 53.13  E-value: 8.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  13 IERDEVRNVFRELEILQEIEHVFLVNLWYSFQD----EEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALD 88
Cdd:cd14030   63 LSKSERQRFKEEAGMLKGLQHPNIVRFYDSWEStvkgKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQ 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  89 YL--RSQHIIHRDVKPDNILLD-EQGHAHLTDFNIATiIKDGERATALAGTKPYMAPEIFHSfvnggtGYSFEVDWWSVG 165
Cdd:cd14030  143 FLhtRTPPIIHRDLKCDNIFITgPTGSVKIGDLGLAT-LKRASFAKSVIGTPEFMAPEMYEE------KYDESVDVYAFG 215
                        170
                 ....*....|...
gi 247269852 166 VMAYELLRGWRPY 178
Cdd:cd14030  216 MCMLEMATSEYPY 228
PTKc_Yes cd05069
Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the ...
22-178 1.01e-07

Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Yes (or c-Yes) is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. c-Yes kinase is the cellular homolog of the oncogenic protein (v-Yes) encoded by the Yamaguchi 73 and Esh sarcoma viruses. It displays functional overlap with other Src subfamily members, particularly Src. It also shows some unique functions such as binding to occludins, transmembrane proteins that regulate extracellular interactions in tight junctions. Yes also associates with a number of proteins in different cell types that Src does not interact with, like JAK2 and gp130 in pre-adipocytes, and Pyk2 in treated pulmonary vein endothelial cells. Although the biological function of Yes remains unclear, it appears to have a role in regulating cell-cell interactions and vesicle trafficking in polarized cells. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Yes subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270654 [Multi-domain]  Cd Length: 279  Bit Score: 52.77  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  22 FRELEILQEIEHVFLVNLwYSFQDEEDMFMV---------VDLLLGGDLRY-HLQQNVQFSEdtvrlyicEMALALDYLR 91
Cdd:cd05069   55 LQEAQIMKKLRHDKLVPL-YAVVSEEPIYIVtefmgkgslLDFLKEGDGKYlKLPQLVDMAA--------QIADGMAYIE 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  92 SQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERaTALAGTK---PYMAPE--IFHSFvnggtgySFEVDWWSVGV 166
Cdd:cd05069  126 RMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEY-TARQGAKfpiKWTAPEaaLYGRF-------TIKSDVWSFGI 197
                        170
                 ....*....|...
gi 247269852 167 MAYELL-RGWRPY 178
Cdd:cd05069  198 LLTELVtKGRVPY 210
STKc_CdkB_plant cd07837
Catalytic domain of the Serine/Threonine Kinase, Plant B-type Cyclin-Dependent protein Kinase; ...
23-226 1.25e-07

Catalytic domain of the Serine/Threonine Kinase, Plant B-type Cyclin-Dependent protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The plant-specific B-type CDKs are expressed from the late S to the M phase of the cell cycle. They are characterized by the cyclin binding motif PPT[A/T]LRE. They play a role in controlling mitosis and integrating developmental pathways, such as stomata and leaf development. CdkB has been shown to associate with both cyclin B, which controls G2/M transition, and cyclin D, which acts as a mediator in linking extracellular signals to the cell cycle. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CdkB subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270830 [Multi-domain]  Cd Length: 294  Bit Score: 52.53  E-value: 1.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEH----VFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSED-----TVRLYICEMALALDYLRSQ 93
Cdd:cd07837   49 REVSLLQMLSQsiyiVRLLDVEHVEENGKPLLYLVFEYLDTDLKKFIDSYGRGPHNplpakTIQSFMYQLCKGVAHCHSH 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  94 HIIHRDVKPDNILLDEQghahltdfniATIIKDGERATALAGTKP------------YMAPEIFHsfvnGGTGYSFEVDW 161
Cdd:cd07837  129 GVMHRDLKPQNLLVDKQ----------KGLLKIADLGLGRAFTIPiksytheivtlwYRAPEVLL----GSTHYSTPVDM 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 162 WSVGVMAYELLRGwRPYDIHSSNaVESLVQLFSTVSV---------------------------QYVPTWSKEMVALLRK 214
Cdd:cd07837  195 WSVGCIFAEMSRK-QPLFPGDSE-LQQLLHIFRLLGTpneevwpgvsklrdwheypqwkpqdlsRAVPDLEPEGVDLLTK 272
                        250
                 ....*....|..
gi 247269852 215 LLTVNPEHRFSS 226
Cdd:cd07837  273 MLAYDPAKRISA 284
PTKc_Axl cd05075
Catalytic domain of the Protein Tyrosine Kinase, Axl; PTKs catalyze the transfer of the ...
3-178 1.28e-07

Catalytic domain of the Protein Tyrosine Kinase, Axl; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Axl is widely expressed in a variety of organs and cells including epithelial, mesenchymal, hematopoietic, as well as non-transformed cells. It is important in many cellular functions such as survival, anti-apoptosis, proliferation, migration, and adhesion. Axl was originally isolated from patients with chronic myelogenous leukemia and a chronic myeloproliferative disorder. It is overexpressed in many human cancers including colon, squamous cell, thyroid, breast, and lung carcinomas. Axl is a member of the TAM subfamily, composed of receptor PTKs (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to its ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. The Axl subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270660 [Multi-domain]  Cd Length: 277  Bit Score: 52.32  E-value: 1.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIeRDEVRNVFRELEILQEIEHVFLVNLW-YSFQDEEDM-----FMVVDLLLGGDLRYHL------QQNVQ 70
Cdd:cd05075   31 AVKTMKIAICT-RSEMEDFLSEAVCMKEFDHPNVMRLIgVCLQNTESEgypspVVILPFMKHGDLHSFLlysrlgDCPVY 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  71 FSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE--RATALAGTK-PYMAPEIFHS 147
Cdd:cd05075  110 LPTQMLVKFMTDIASGMEYLSSKNFIHRDLAARNCMLNENMNVCVADFGLSKKIYNGDyyRQGRISKMPvKWIAIESLAD 189
                        170       180       190
                 ....*....|....*....|....*....|..
gi 247269852 148 FVnggtgYSFEVDWWSVGVMAYEL-LRGWRPY 178
Cdd:cd05075  190 RV-----YTTKSDVWSFGVTMWEIaTRGQTPY 216
PTKc_Kit cd05104
Catalytic domain of the Protein Tyrosine Kinase, Kit; PTKs catalyze the transfer of the ...
82-178 1.36e-07

Catalytic domain of the Protein Tyrosine Kinase, Kit; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Kit is important in the development of melanocytes, germ cells, mast cells, hematopoietic stem cells, the interstitial cells of Cajal, and the pacemaker cells of the GI tract. Kit signaling is involved in major cellular functions including cell survival, proliferation, differentiation, adhesion, and chemotaxis. Mutations in Kit, which result in constitutive ligand-independent activation, are found in human cancers such as gastrointestinal stromal tumor (GIST) and testicular germ cell tumor (TGCT). The aberrant expression of Kit and/or SCF is associated with other tumor types such as systemic mastocytosis and cancers of the breast, neurons, lung, prostate, colon, and rectum. Although the structure of the human Kit catalytic domain is known, it is excluded from this specific alignment model because it contains a deletion in its sequence. Kit is a member of the Platelet Derived Growth Factor Receptor (PDGFR) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of Kit to its ligand, the stem-cell factor (SCF), leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. The Kit subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270682 [Multi-domain]  Cd Length: 375  Bit Score: 52.98  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTK---PYMAPE-IFHSFvnggtgYSF 157
Cdd:cd05104  222 QVAKGMEFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARlpvKWMAPEsIFECV------YTF 295
                         90       100
                 ....*....|....*....|..
gi 247269852 158 EVDWWSVGVMAYELLR-GWRPY 178
Cdd:cd05104  296 ESDVWSYGILLWEIFSlGSSPY 317
PTKc_VEGFR3 cd05102
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3; ...
73-178 1.38e-07

Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR3 (or Flt4) preferentially binds the ligands VEGFC and VEGFD. VEGFR3 is essential for lymphatic endothelial cell (EC) development and function. It has been shown to regulate adaptive immunity during corneal transplantation. VEGFR3 is upregulated on blood vascular ECs in pathological conditions such as vascular tumors and the periphery of solid tumors. It plays a role in cancer progression and lymph node metastasis. Missense mutations in the VEGFR3 gene are associated with primary human lymphedema. VEGFR3 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. In VEGFR3, the fifth Ig-like domain is replaced by a disulfide bridge. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270680 [Multi-domain]  Cd Length: 336  Bit Score: 52.67  E-value: 1.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  73 EDTVrLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIA-TIIKDGERATALAGTKP--YMAPE-IFHSF 148
Cdd:cd05102  172 EDLI-CYSFQVARGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLArDIYKDPDYVRKGSARLPlkWMAPEsIFDKV 250
                         90       100       110
                 ....*....|....*....|....*....|.
gi 247269852 149 vnggtgYSFEVDWWSVGVMAYELLR-GWRPY 178
Cdd:cd05102  251 ------YTTQSDVWSFGVLLWEIFSlGASPY 275
PTKc_RET cd05045
Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein; PTKs ...
17-223 1.58e-07

Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. RET is a receptor PTK (RTK) containing an extracellular region with four cadherin-like repeats, a calcium-binding site, and a cysteine-rich domain, a transmembrane segment, and an intracellular catalytic domain. It is part of a multisubunit complex that binds glial-derived neurotropic factor (GDNF) family ligands (GFLs) including GDNF, neurturin, artemin, and persephin. GFLs bind RET along with four GPI-anchored coreceptors, bringing two RET molecules together, leading to autophosphorylation, activation, and intracellular signaling. RET is essential for the development of the sympathetic, parasympathetic and enteric nervous systems, and the kidney. RET disruption by germline mutations causes diseases in humans including congenital aganglionosis of the gastrointestinal tract (Hirschsprung's disease) and three related inherited cancers: multiple endocrine neoplasia type 2A (MEN2A), MEN2B, and familial medullary thyroid carcinoma. The RET subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173631 [Multi-domain]  Cd Length: 290  Bit Score: 52.27  E-value: 1.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  17 EVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQ-----------------FSED----T 75
Cdd:cd05045   46 ELRDLLSEFNLLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRSFLRESRKvgpsylgsdgnrnssylDNPDeralT 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  76 VRLYIC---EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIA-TIIKDGERATALAGTKP--YMAPEIFHSFV 149
Cdd:cd05045  126 MGDLISfawQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFGLSrDVYEEDSYVKRSKGRIPvkWMAIESLFDHI 205
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 150 nggtgYSFEVDWWSVGVMAYELLR-GWRPYdihSSNAVESLVQLFSTVSVQYVP-TWSKEMVALLRKLLTVNPEHR 223
Cdd:cd05045  206 -----YTTQSDVWSFGVLLWEIVTlGGNPY---PGIAPERLFNLLKTGYRMERPeNCSEEMYNLMLTCWKQEPDKR 273
STKc_LIMK cd14154
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase; STKs catalyze the transfer ...
5-172 1.61e-07

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. Vertebrate have two members, LIMK1 and LIMK2. The LIMK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271056 [Multi-domain]  Cd Length: 272  Bit Score: 52.12  E-value: 1.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   5 KYMNKQQCIERDE--VRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLR---------YHLQQNVQFSE 73
Cdd:cd14154   19 EVMVMKELIRFDEeaQRNFLKEVKVMRSLDHPNVLKFIGVLYKDKKLNLITEYIPGGTLKdvlkdmarpLPWAQRVRFAK 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  74 DTVrlyiCEMAlaldYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATII---KDGERATALAGTK------------- 137
Cdd:cd14154   99 DIA----SGMA----YLHSMNIIHRDLNSHNCLVREDKTVVVADFGLARLIveeRLPSGNMSPSETLrhlkspdrkkryt 170
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 247269852 138 ----PY-MAPEIFHsfvngGTGYSFEVDWWSVGVMAYELL 172
Cdd:cd14154  171 vvgnPYwMAPEMLN-----GRSYDEKVDIFSFGIVLCEII 205
PTKc_Csk_like cd05039
Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
65-178 1.66e-07

Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of Csk, Chk, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. They negatively regulate the activity of Src kinases that are anchored to the plasma membrane. To inhibit Src kinases, Csk and Chk are translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. Csk catalyzes the tyr phosphorylation of the regulatory C-terminal tail of Src kinases, resulting in their inactivation. Chk inhibit Src kinases using a noncatalytic mechanism by simply binding to them. As negative regulators of Src kinases, Csk and Chk play important roles in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. The Csk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270635 [Multi-domain]  Cd Length: 256  Bit Score: 51.97  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  65 LQQNVQFSEDTvrlyiCEmalALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAtiiKDGERATAlAGTKP--YMAP 142
Cdd:cd05039  101 RKDQLGFALDV-----CE---GMEYLESKKFVHRDLAARNVLVSEDNVAKVSDFGLA---KEASSNQD-GGKLPikWTAP 168
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 247269852 143 E-IFHSFvnggtgYSFEVDWWSVGVMAYELLR-GWRPY 178
Cdd:cd05039  169 EaLREKK------FSTKSDVWSFGILLWEIYSfGRVPY 200
PTKc_VEGFR cd05054
Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; ...
17-178 1.85e-07

Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The VEGFR subfamily consists of VEGFR1 (Flt1), VEGFR2 (Flk1), VEGFR3 (Flt4), and similar proteins. VEGFR subfamily members are receptor PTKss (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. In VEGFR3, the fifth Ig-like domain is replaced by a disulfide bridge. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. There are five VEGF ligands in mammals, which bind, in an overlapping pattern to the three VEGFRs, which can form homo or heterodimers. VEGFRs regulate the cardiovascular system. They are critical for vascular development during embryogenesis and blood vessel formation in adults. They induce cellular functions common to other growth factor receptors such as cell migration, survival, and proliferation. The VEGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270647 [Multi-domain]  Cd Length: 298  Bit Score: 52.11  E-value: 1.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  17 EVRNVFRELEILQEI-EHVFLVNLWYSFQDEEDMFMV-VDLLLGGDLRYHLQ--------------QNVQFSEDTVRLY- 79
Cdd:cd05054   53 EHKALMTELKILIHIgHHLNVVNLLGACTKPGGPLMViVEFCKFGNLSNYLRskreefvpyrdkgaRDVEEEEDDDELYk 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 --------IC---EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIA-TIIKDGERATALAGTKP--YMAPE-I 144
Cdd:cd05054  133 epltledlICysfQVARGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLArDIYKDPDYVRKGDARLPlkWMAPEsI 212
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 247269852 145 FHSFvnggtgYSFEVDWWSVGVMAYELLR-GWRPY 178
Cdd:cd05054  213 FDKV------YTTQSDVWSFGVLLWEIFSlGASPY 241
PTKc_Met_Ron cd05058
Catalytic domain of the Protein Tyrosine Kinases, Met and Ron; PTKs catalyze the transfer of ...
3-202 2.22e-07

Catalytic domain of the Protein Tyrosine Kinases, Met and Ron; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Met and Ron are receptor PTKs (RTKs) composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. Met binds to the ligand, hepatocyte growth factor/scatter factor (HGF/SF), and is also called the HGF receptor. HGF/Met signaling plays a role in growth, transformation, cell motility, invasion, metastasis, angiogenesis, wound healing, and tissue regeneration. Aberrant expression of Met through mutations or gene amplification is associated with many human cancers including hereditary papillary renal and gastric carcinomas. The ligand for Ron is macrophage stimulating protein (MSP). Ron signaling is important in regulating cell motility, adhesion, proliferation, and apoptosis. Aberrant Ron expression is implicated in tumorigenesis and metastasis. The Met/Ron subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270649 [Multi-domain]  Cd Length: 262  Bit Score: 51.71  E-value: 2.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIErdEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVV-DLLLGGDLRYHLQQNVQfsEDTVRLYI- 80
Cdd:cd05058   27 AVKSLNRITDIE--EVEQFLKEGIIMKDFSHPNVLSLLGICLPSEGSPLVVlPYMKHGDLRNFIRSETH--NPTVKDLIg 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  81 --CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE-----RATALAGTKPYMAPEIFHSfvnggT 153
Cdd:cd05058  103 fgLQVAKGMEYLASKKFVHRDLAARNCMLDESFTVKVADFGLARDIYDKEyysvhNHTGAKLPVKWMALESLQT-----Q 177
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 247269852 154 GYSFEVDWWSVGVMAYELL-RGWRPY-DIHSSNAVESLVQLFSTVSVQYVP 202
Cdd:cd05058  178 KFTTKSDVWSFGVLLWELMtRGAPPYpDVDSFDITVYLLQGRRLLQPEYCP 228
PHA03210 PHA03210
serine/threonine kinase US3; Provisional
3-198 2.40e-07

serine/threonine kinase US3; Provisional


Pssm-ID: 165476 [Multi-domain]  Cd Length: 501  Bit Score: 52.39  E-value: 2.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQqcierdevrNVFRELEILQEIEHVFLVNLWYSFqdeeDMFmvvDLLLGGDLRYHLQQNVQFSEDTVRLYICe 82
Cdd:PHA03210 216 ALGRLNHE---------NILKIEEILRSEANTYMITQKYDF----DLY---SFMYDEAFDWKDRPLLKQTRAIMKQLLC- 278
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 malALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE--RATALAGTKPYMAPEIFhsfvnGGTGYSFEVD 160
Cdd:PHA03210 279 ---AVEYIHDKKLIHRDIKLENIFLNCDGKIVLGDFGTAMPFEKEReaFDYGWVGTVATNSPEIL-----AGDGYCEITD 350
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 247269852 161 WWSVGVMAYELL-RGWRPYDIHSSNAVESLVQLFSTVSV 198
Cdd:PHA03210 351 IWSCGLILLDMLsHDFCPIGDGGGKPGKQLLKIIDSLSV 389
PKc_DYRK4 cd14225
Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and ...
56-175 2.63e-07

Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. DYRK4 is a testis-specific kinase with restricted expression to postmeiotic spermatids. It may function during spermiogenesis, however, it is not required for male fertility. DYRK4 has also been detected in a human teratocarcinoma cell line induced to produce postmitotic neurons. It may have a role in neuronal differentiation. DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. They play important roles in cell proliferation, differentiation, survival, and development. The DYRK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271127 [Multi-domain]  Cd Length: 341  Bit Score: 52.01  E-value: 2.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  56 LLGGDLrYHL--QQNVQ-FSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATA 132
Cdd:cd14225  126 LLGMNL-YELikKNNFQgFSLSLIRRFAISLLQCLRLLYRERIIHCDLKPENILLRQRGQSSIKVIDFGSSCYEHQRVYT 204
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 247269852 133 LAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLRGW 175
Cdd:cd14225  205 YIQSRFYRSPEVIL-----GLPYSMAIDMWSLGCILAELYTGY 242
STKc_HIPK cd14211
Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase; STKs ...
24-178 2.65e-07

Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HIPKs, originally identified by their ability to bind homeobox factors, are nuclear proteins containing catalytic kinase and homeobox-interacting domains as well as a PEST region overlapping with the speckle-retention signal (SRS). They show speckled localization in the nucleus, apart from the nucleoles. They play roles in the regulation of many nuclear pathways including gene transcription, cell survival, proliferation, differentiation, development, and DNA damage response. Vertebrates contain three HIPKs (HIPK1-3) and mammals harbor an additional family member HIPK4, which does not contain a homeobox-interacting domain and is localized in the cytoplasm. HIPK2, the most studied HIPK, is a coregulator of many transcription factors and cofactors and it regulates gene transcription during development and in DNA damage response. The HIPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271113 [Multi-domain]  Cd Length: 329  Bit Score: 51.68  E-value: 2.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  24 ELEILQEI------EHVFlVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQNvQFSEDT---VRLYICEMALALDYLRSQH 94
Cdd:cd14211   45 EVSILSRLsqenadEFNF-VRAYECFQHKNHTCLVFEML-EQNLYDFLKQN-KFSPLPlkyIRPILQQVLTALLKLKSLG 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  95 IIHRDVKPDNILLDEQG----HAHLTDFNIATIIKDGERATALAgTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYE 170
Cdd:cd14211  122 LIHADLKPENIMLVDPVrqpyRVKVIDFGSASHVSKAVCSTYLQ-SRYYRAPEIIL-----GLPFCEAIDMWSLGCVIAE 195

                 ....*...
gi 247269852 171 LLRGWRPY 178
Cdd:cd14211  196 LFLGWPLY 203
PTKc_Src cd05071
Catalytic domain of the Protein Tyrosine Kinase, Src; PTKs catalyze the transfer of the ...
22-178 2.68e-07

Catalytic domain of the Protein Tyrosine Kinase, Src; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Src (or c-Src) is a cytoplasmic (or non-receptor) PTK, containing an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region with a conserved tyr. It is activated by autophosphorylation at the tyr kinase domain, and is negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). c-Src is the vertebrate homolog of the oncogenic protein (v-Src) from Rous sarcoma virus. Together with other Src subfamily proteins, it is involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. Src also play a role in regulating cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. Elevated levels of Src kinase activity have been reported in a variety of human cancers. Several inhibitors of Src have been developed as anti-cancer drugs. Src is also implicated in acute inflammatory responses and osteoclast function. The Src subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270656 [Multi-domain]  Cd Length: 277  Bit Score: 51.61  E-value: 2.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  22 FRELEILQEIEHVFLVNLwYSFQDEEDMFMVVDLLLGGDLRYHLQQNvqfSEDTVRL-----YICEMALALDYLRSQHII 96
Cdd:cd05071   52 LQEAQVMKKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGE---MGKYLRLpqlvdMAAQIASGMAYVERMNYV 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  97 HRDVKPDNILLDEQGHAHLTDFNIATIIKDGERaTALAGTK---PYMAPE--IFHSFvnggtgySFEVDWWSVGVMAYEL 171
Cdd:cd05071  128 HRDLRAANILVGENLVCKVADFGLARLIEDNEY-TARQGAKfpiKWTAPEaaLYGRF-------TIKSDVWSFGILLTEL 199

                 ....*...
gi 247269852 172 -LRGWRPY 178
Cdd:cd05071  200 tTKGRVPY 207
STKc_CDC2L6 cd07867
Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6; STKs catalyze the ...
23-231 2.71e-07

Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDC2L6 is also called CDK8-like and was previously referred to as CDK11. However, this is a confusing nomenclature as CDC2L6 is distinct from CDC2L1, which is represented by the two protein products from its gene, called CDK11(p110) and CDK11(p58), as well as the caspase-processed CDK11(p46). CDK11(p110), CDK11(p58), and CDK11(p46)do not belong to this subfamily. CDC2L6 is an associated protein of Mediator, a multiprotein complex that provides a platform to connect transcriptional and chromatin regulators and cofactors, in order to activate and mediate RNA polymerase II transcription. CDC2L6 is localized mainly in the nucleus amd exerts an opposing effect to CDK8 in VP16-dependent transcriptional activation by being a negative regulator. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDC2L6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270850 [Multi-domain]  Cd Length: 318  Bit Score: 51.61  E-value: 2.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEED-----MFMVVDLLLGGDLRYHL-----QQNVQFSEDTVRLYICEMALALDYLRS 92
Cdd:cd07867   48 REIALLRELKHPNVIALQKVFLSHSDrkvwlLFDYAEHDLWHIIKFHRaskanKKPMQLPRSMVKSLLYQILDGIHYLHA 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILL----DEQGHAHLTDFNIATIIKDGERATA----LAGTKPYMAPEIFHsfvnGGTGYSFEVDWWSV 164
Cdd:cd07867  128 NWVLHRDLKPANILVmgegPERGRVKIADMGFARLFNSPLKPLAdldpVVVTFWYRAPELLL----GARHYTKAIDIWAI 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 165 GVMAYELLRG-----WRPYDIHSSNAV--ESLVQLFSTV------------SVQYVPTWSKE------------------ 207
Cdd:cd07867  204 GCIFAELLTSepifhCRQEDIKTSNPFhhDQLDRIFSVMgfpadkdwedirKMPEYPTLQKDfrrttyansslikymekh 283
                        250       260       270
                 ....*....|....*....|....*....|.
gi 247269852 208 -------MVALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd07867  284 kvkpdskVFLLLQKLLTMDPTKRITSEQALQ 314
STKc_PDIK1L cd13977
Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like; STKs ...
49-228 3.43e-07

Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PDIK1L is also called STK35 or CLIK-1. It is predominantly a nuclear protein which is capable of autophosphorylation. Through its interaction with the PDZ-LIM protein CLP-36, it is localized to actin stress fibers. The PDIK1L subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270879 [Multi-domain]  Cd Length: 322  Bit Score: 51.40  E-value: 3.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  49 MFMVVDLLLGGDLRYHLQQNvQFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHA---HLTDFNIATIIK 125
Cdd:cd13977  110 LWFVMEFCDGGDMNEYLLSR-RPDRQTNTSFMLQLSSALAFLHRNQIVHRDLKPDNILISHKRGEpilKVADFGLSKVCS 188
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 126 ------------DGERATALAGTKPYMAPEIFHSFvnggtgYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAV------- 186
Cdd:cd13977  189 gsglnpeepanvNKHFLSSACGSDFYMAPEVWEGH------YTAKADIFALGIIIWAMVERITFRDGETKKELlgtyiqq 262
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 247269852 187 --------ESLVQ---LFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd13977  263 gkeivplgEALLEnpkLELQIPLKKKKSMNDDMKQLLRDMLAANPQERPDAFQ 315
STKc_CDK8 cd07868
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8; STKs ...
23-231 3.48e-07

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK8 can act as a negative or positive regulator of transcription, depending on the scenario. Together with its regulator, cyclin C, it reversibly associates with the multi-subunit core Mediator complex, a cofactor that is involved in regulating RNA polymerase II (RNAP II)-dependent transcription. CDK8 phosphorylates cyclin H, a subunit of the general transcription factor TFIIH, which results in the inhibition of TFIIH-dependent phosphorylation of the C-terminal domain of RNAP II, facilitating the inhibition of transcription. It has also been shown to promote transcription by a mechanism that is likely to involve RNAP II phosphorylation. CDK8 also functions as a stimulus-specific positive coregulator of p53 transcriptional responses. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK8 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270851 [Multi-domain]  Cd Length: 333  Bit Score: 51.60  E-value: 3.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEED-----MFMVVDLLLGGDLRYHL-----QQNVQFSEDTVRLYICEMALALDYLRS 92
Cdd:cd07868   63 REIALLRELKHPNVISLQKVFLSHADrkvwlLFDYAEHDLWHIIKFHRaskanKKPVQLPRGMVKSLLYQILDGIHYLHA 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  93 QHIIHRDVKPDNILL----DEQGHAHLTDFNIATIIKDGERATA----LAGTKPYMAPEIFHsfvnGGTGYSFEVDWWSV 164
Cdd:cd07868  143 NWVLHRDLKPANILVmgegPERGRVKIADMGFARLFNSPLKPLAdldpVVVTFWYRAPELLL----GARHYTKAIDIWAI 218
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 165 GVMAYELLRG-----WRPYDIHSSNAV--ESLVQLFSTV---------SVQYVPTWSKEM-------------------- 208
Cdd:cd07868  219 GCIFAELLTSepifhCRQEDIKTSNPYhhDQLDRIFNVMgfpadkdweDIKKMPEHSTLMkdfrrntytncslikymekh 298
                        250       260       270
                 ....*....|....*....|....*....|.
gi 247269852 209 --------VALLRKLLTVNPEHRFSSLQDMQ 231
Cdd:cd07868  299 kvkpdskaFHLLQKLLTMDPIKRITSEQAMQ 329
PTKc_Fyn cd05070
Catalytic domain of the Protein Tyrosine Kinase, Fyn; PTKs catalyze the transfer of the ...
22-178 3.54e-07

Catalytic domain of the Protein Tyrosine Kinase, Fyn; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fyn and Yrk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Fyn, together with Lck, plays a critical role in T-cell signal transduction by phosphorylating ITAM (immunoreceptor tyr activation motif) sequences on T-cell receptors, ultimately leading to the proliferation and differentiation of T-cells. In addition, Fyn is involved in the myelination of neurons, and is implicated in Alzheimer's and Parkinson's diseases. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Fyn/Yrk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase.


Pssm-ID: 270655 [Multi-domain]  Cd Length: 274  Bit Score: 51.22  E-value: 3.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  22 FRELEILQEIEHVFLVNLwYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRL--YICEMALALDYLRSQHIIHRD 99
Cdd:cd05070   52 LEEAQIMKKLKHDKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLvdMAAQVAAGMAYIERMNYIHRD 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 100 VKPDNILLDEQGHAHLTDFNIATIIKDGERaTALAGTK---PYMAPE--IFHSFvnggtgySFEVDWWSVGVMAYELL-R 173
Cdd:cd05070  131 LRSANILVGNGLICKIADFGLARLIEDNEY-TARQGAKfpiKWTAPEaaLYGRF-------TIKSDVWSFGILLTELVtK 202

                 ....*
gi 247269852 174 GWRPY 178
Cdd:cd05070  203 GRVPY 207
STKc_MLTK cd14060
Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated ...
1-178 3.61e-07

Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLTK, also called zipper sterile-alpha-motif kinase (ZAK), contains a catalytic kinase domain and a leucine zipper. There are two alternatively-spliced variants, MLTK-alpha and MLTK-beta. MLTK-alpha contains a sterile-alpha-motif (SAM) at the C-terminus. MLTK regulates the c-Jun N-terminal kinase, extracellular signal-regulated kinase, p38 MAPK, and NF-kB pathways. ZAK is the MAP3K involved in the signaling cascade that leads to the ribotoxic stress response initiated by cellular damage due to Shiga toxins and ricin. It may also play a role in cell transformation and cancer development. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals.The MLTK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270962 [Multi-domain]  Cd Length: 242  Bit Score: 50.73  E-value: 3.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   1 MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQN--VQFSEDTVRL 78
Cdd:cd14060    9 VYRAIWVSQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGAILEAPNYGIVTEYASYGSLFDYLNSNesEEMDMDQIMT 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  79 YICEMALALDYLRSQ---HIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATaLAGTKPYMAPEIFHSFVNGGTgy 155
Cdd:cd14060   89 WATDIAKGMHYLHMEapvKVIHRDLKSRNVVIAADGVLKICDFGASRFHSHTTHMS-LVGTFPWMAPEVIQSLPVSET-- 165
                        170       180
                 ....*....|....*....|...
gi 247269852 156 sfeVDWWSVGVMAYELLRGWRPY 178
Cdd:cd14060  166 ---CDTYSYGVVLWEMLTREVPF 185
Kinase-like pfam14531
Kinase-like; This family includes the pseudokinases ROP2 and ROP8 from Toxoplasma gondii. ...
44-223 4.44e-07

Kinase-like; This family includes the pseudokinases ROP2 and ROP8 from Toxoplasma gondii. These proteins have a typical bilobed protein kinase fold, but lack catalytic actvity.


Pssm-ID: 405254 [Multi-domain]  Cd Length: 288  Bit Score: 50.96  E-value: 4.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   44 QDEEDMFMVVDLLLGGDLRYHLQ---------QNVQFSEDTV-RLYICEMALAL-DYLRSQHIIHRDVKPDNILLDEQGH 112
Cdd:pfam14531 103 SDETDYWVANYLLLYPAMSVDLQllgevllshSSTHKSLVHHaRLQLTLQLIRLaANLQHYGLVHGQFTVDNFFLDQRGG 182
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  113 AHLTDFniATIIKDGERATALAGTKPYMAPEIFHSFVNGG----TGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVES 188
Cdd:pfam14531 183 VFLGGF--EHLVRDGTKVVASEVPRGFAPPELLGSRGGYTmkntTLMTHAFDAWQLGLVIYWIWCLDLPNTLDAEEGGIE 260
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 247269852  189 lvqlFSTVSVQYVPTWSKemvALLRKLLTVNPEHR 223
Cdd:pfam14531 261 ----WKFRLCKNIPEPVR---ALLKGFLNYSQEDR 288
pknD PRK13184
serine/threonine-protein kinase PknD;
80-233 4.44e-07

serine/threonine-protein kinase PknD;


Pssm-ID: 183880 [Multi-domain]  Cd Length: 932  Bit Score: 51.69  E-value: 4.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  80 ICEmalALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIAtIIKDGERATALA--------------------GTKPY 139
Cdd:PRK13184 122 ICA---TIEYVHSKGVLHRDLKPDNILLGLFGEVVILDWGAA-IFKKLEEEDLLDidvdernicyssmtipgkivGTPDY 197
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 140 MAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLRGWRPY------DIHSSNAVESLVQLFSTVSVQyvPTWSKemVALlr 213
Cdd:PRK13184 198 MAPERLL-----GVPASESTDIYALGVILYQMLTLSFPYrrkkgrKISYRDVILSPIEVAPYREIP--PFLSQ--IAM-- 266
                        170       180
                 ....*....|....*....|
gi 247269852 214 KLLTVNPEHRFSSLQDMQTA 233
Cdd:PRK13184 267 KALAVDPAERYSSVQELKQD 286
PKc_TESK cd14155
Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase; ...
20-172 4.57e-07

Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TESK proteins phosphorylate cofilin and induce actin cytoskeletal reorganization. In the Drosphila eye, TESK is required for epithelial cell organization. Mammals contain two TESK proteins, TESK1 and TESK2, which are highly expressed in testis and play roles in spermatogenesis. TESK1 is found in testicular germ cells while TESK2 is expressed mainly in nongerminal Sertoli cells. TESK1 is stimulated by integrin-mediated signaling pathways. It regulates cell spreading and focal adhesion formation. The TESK subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271057 [Multi-domain]  Cd Length: 253  Bit Score: 50.55  E-value: 4.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  20 NVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEdTVRLYIC-EMALALDYLRSQHIIHR 98
Cdd:cd14155   34 NMLREVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINGGNLEQLLDSNEPLSW-TVRVKLAlDIARGLSYLHSKGIFHR 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  99 DVKPDNILL--DEQGH-AHLTDFNIATII---KDGERATALAGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYELL 172
Cdd:cd14155  113 DLTSKNCLIkrDENGYtAVVGDFGLAEKIpdySDGKEKLAVVGSPYWMAPEVLR-----GEPYNEKADVFSYGIILCEII 187
STKc_ACVR2a cd14141
Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor; STKs catalyze the ...
48-171 5.00e-07

Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR2a (or ActRIIA) belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. ACVR2b is one of two ACVR2 receptors found in vertebrates. Type II receptors are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. ACVR2 acts primarily as the receptors for activins, nodal, myostatin, GDF11, and a subset of BMPs. ACVR2 signaling impacts many cellular and physiological processes including reproductive and gonadal functions, myogenesis, bone remodeling and tooth development, kidney organogenesis, apoptosis, fibrosis, inflammation, and neurogenesis. The ACVR2a subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271043 [Multi-domain]  Cd Length: 290  Bit Score: 50.81  E-value: 5.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  48 DMFMVVDLLLGGDLRYHLQQNVqFSEDTVRLYICEMALALDYLRSQ----------HIIHRDVKPDNILLDEQGHAHLTD 117
Cdd:cd14141   67 DLWLITAFHEKGSLTDYLKANV-VSWNELCHIAQTMARGLAYLHEDipglkdghkpAIAHRDIKSKNVLLKNNLTACIAD 145
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 118 FNIATIIKDGERAT---ALAGTKPYMAPEIFHSFVNGGTGYSFEVDWWSVGVMAYEL 171
Cdd:cd14141  146 FGLALKFEAGKSAGdthGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWEL 202
STKc_KSR1 cd14152
Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1; STKs catalyze the ...
82-230 5.04e-07

Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. KSR1 functions as a transducer of TNFalpha-stimulated C-Raf activation of ERK1/2 and NF-kB. Detected activity of KSR1 is cell type specific and context dependent. It is inactive in normal colon epithelial cells and becomes activated at the onset of inflammatory bowel disease (IBD). Similarly, KSR1 activity is undetectable prior to stimulation by EGF or ceramide in COS-7 or YAMC cells, respectively. KSR proteins are widely regarded as pseudokinases, however, this matter is up for debate as catalytic activity has been detected for KSR1 in some systems. The KSR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271054 [Multi-domain]  Cd Length: 279  Bit Score: 50.74  E-value: 5.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDeQGHAHLTD---FNIATIIKDGERATALAGTKP---YMAPEIFHSFVNGGTG- 154
Cdd:cd14152  105 EIIKGMGYLHAKGIVHKDLKSKNVFYD-NGKVVITDfglFGISGVVQEGRRENELKLPHDwlcYLAPEIVREMTPGKDEd 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 155 ---YSFEVDWWSVGVMAYEL-LRGWrPYDIHSSNAV-------ESLVQLFSTVSVqyvptwSKEMVALLRKLLTVNPEHR 223
Cdd:cd14152  184 clpFSKAADVYAFGTIWYELqARDW-PLKNQPAEALiwqigsgEGMKQVLTTISL------GKEVTEILSACWAFDLEER 256

                 ....*....
gi 247269852 224 --FSSLQDM 230
Cdd:cd14152  257 psFTLLMDM 265
PK_GC cd13992
Pseudokinase domain of membrane Guanylate Cyclase receptors; The pseudokinase domain shows ...
3-223 5.58e-07

Pseudokinase domain of membrane Guanylate Cyclase receptors; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs lack a critical aspartate involved in ATP binding and does not exhibit kinase activity. It functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270894 [Multi-domain]  Cd Length: 268  Bit Score: 50.47  E-value: 5.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQqcieRDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRL-YIC 81
Cdd:cd13992   29 AIKHITFS----RTEKRTILQELNQLKELVHDNLNKFIGICINPPNIAVVTEYCTRGSLQDVLLNREIKMDWMFKSsFIK 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHII-HRDVKPDNILLDEQGHAHLTDFNIATIIKDGERA----TALAGTKPYMAPEIFHSFVNGGTGyS 156
Cdd:cd13992  105 DIVKGMNYLHSSSIGyHGRLKSSNCLVDSRWVVKLTDFGLRNLLEEQTNHqldeDAQHKKLLWTAPELLRGSLLEVRG-T 183
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 247269852 157 FEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQL---FSTVSVQYVPTWSKEM--VALLRKLLTVNPEHR 223
Cdd:cd13992  184 QKGDVYSFAIILYEILFRSDPFALEREVAIVEKVISggnKPFRPELAVLLDEFPPrlVLLVKQCWAENPEKR 255
STKc_LIMK2 cd14222
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2; STKs catalyze the ...
5-172 8.11e-07

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMK2 activation is induced by transforming growth factor-beta l (TGFb-l) and shares the same subcellular location as the cofilin family member twinfilin, which may be its biological substrate. LIMK2 plays a role in spermatogenesis, and may contribute to tumor progression and metastasis formation in some cancer cells. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. The LIMK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271124 [Multi-domain]  Cd Length: 272  Bit Score: 49.94  E-value: 8.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   5 KYMNKQQCIERDE--VRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL--------QQNVQFSED 74
Cdd:cd14222   19 KVMVMKELIRCDEetQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKRLNLLTEFIEGGTLKDFLraddpfpwQQKVSFAKG 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  75 TVrlyiCEMAlaldYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATII---------------------KDGERATAL 133
Cdd:cd14222   99 IA----SGMA----YLHSMSIIHRDLNSHNCLIKLDKTVVVADFGLSRLIveekkkpppdkpttkkrtlrkNDRKKRYTV 170
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 247269852 134 AGTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYELL 172
Cdd:cd14222  171 VGNPYWMAPEMLN-----GKSYDEKVDIFSFGIVLCEII 204
STKc_EIF2AK1_HRI cd14049
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
87-228 9.16e-07

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HRI (or EIF2AK1) contains an N-terminal regulatory heme-binding domain and a C-terminal catalytic kinase domain. It is suppressed under normal conditions by binding of the heme iron, and is activated during heme deficiency. It functions as a critical regulator that ensures balanced synthesis of globins and heme, in order to form stable hemoglobin during erythroid differentiation and maturation. HRI also protects cells and enhances survival under iron-deficient conditions. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The HRI subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270951 [Multi-domain]  Cd Length: 284  Bit Score: 49.81  E-value: 9.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  87 LDYLRSQHIIHRDVKPDNILLDEQG-HAHLTDFNIAT--IIKDGERA-----------TALAGTKPYMAPEIFHsfvngG 152
Cdd:cd14049  133 VTYIHSMGIVHRDLKPRNIFLHGSDiHVRIGDFGLACpdILQDGNDSttmsrlnglthTSGVGTCLYAAPEQLE-----G 207
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 153 TGYSFEVDWWSVGVMAYELLrgwRPYDIHSSNAvESLVQLFS-TVSVQYVPTWsKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd14049  208 SHYDFKSDMYSIGVILLELF---QPFGTEMERA-EVLTQLRNgQIPKSLCKRW-PVQAKYIKLLTSTEPSERPSASQ 279
STKc_SHIK cd13974
Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase; STKs ...
60-228 1.14e-06

Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SHIK, also referred to as STK40 or LYK4, is a cytoplasmic and nuclear protein that is involved in the negative regulation of NF-kappaB- and p53-mediated transcription. It was identified as a protein related to SINK, a p65-interacting protein that inhibits p65 phosphorylation by the catalytic subunit of PKA, thereby inhibiting transcriptional competence of NF-kappaB. The SHIK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270876 [Multi-domain]  Cd Length: 290  Bit Score: 49.71  E-value: 1.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  60 DLRYHLQQNVQFSE--------DTVRLYICemalaldyLRSQHIIHRDVKPDNILLDEQGH-AHLTDFNIAT-IIKDGER 129
Cdd:cd13974  118 NLQHYVIREKRLSErealvifyDVVRVVEA--------LHKKNIVHRDLKLGNMVLNKRTRkITITNFCLGKhLVSEDDL 189
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 130 ATALAGTKPYMAPEifhsfVNGGTGYSFE-VDWWSVGVMAYELLRGWRP-YDIHSSnaveslvQLFSTV-SVQY-VPT-- 203
Cdd:cd13974  190 LKDQRGSPAYISPD-----VLSGKPYLGKpSDMWALGVVLFTMLYGQFPfYDSIPQ-------ELFRKIkAAEYtIPEdg 257
                        170       180
                 ....*....|....*....|....*.
gi 247269852 204 -WSKEMVALLRKLLTVNPEHRFSSLQ 228
Cdd:cd13974  258 rVSENTVCLIRKLLVLNPQKRLTASE 283
PTKc_Ror1 cd05090
Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor ...
23-191 1.39e-06

Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Ror kinases are expressed in many tissues during development. Avian Ror1 was found to be involved in late limb development. Studies in mice reveal that Ror1 is important in the regulation of neurite growth in central neurons, as well as in respiratory development. Loss of Ror1 also enhances the heart and skeletal abnormalities found in Ror2-deficient mice. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The Ror1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270672 [Multi-domain]  Cd Length: 283  Bit Score: 49.24  E-value: 1.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL-----QQNVQFSED---TVR--------LYIC-EMAL 85
Cdd:cd05090   56 QEASLMTELHHPNIVCLLGVVTQEQPVCMLFEFMNQGDLHEFLimrspHSDVGCSSDedgTVKssldhgdfLHIAiQIAA 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  86 ALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE----RATALAGTKpYMAPEifhSFVNGgtGYSFEVDW 161
Cdd:cd05090  136 GMEYLSSHFFVHKDLAARNILVGEQLHVKISDLGLSREIYSSDyyrvQNKSLLPIR-WMPPE---AIMYG--KFSSDSDI 209
                        170       180       190
                 ....*....|....*....|....*....|.
gi 247269852 162 WSVGVMAYELLR-GWRPYDIHSSNAVESLVQ 191
Cdd:cd05090  210 WSFGVVLWEIFSfGLQPYYGFSNQEVIEMVR 240
PTKc_Trk cd05049
Catalytic domain of the Protein Tyrosine Kinases, Tropomyosin Related Kinases; PTKs catalyze ...
23-186 1.60e-06

Catalytic domain of the Protein Tyrosine Kinases, Tropomyosin Related Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Trk subfamily consists of TrkA, TrkB, TrkC, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, the nerve growth factor (NGF) family of neutrotrophins, leads to Trk receptor oligomerization and activation of the catalytic domain. Trk receptors are mainly expressed in the peripheral and central nervous systems. They play important roles in cell fate determination, neuronal survival and differentiation, as well as in the regulation of synaptic plasticity. Altered expression of Trk receptors is associated with many human diseases. The Trk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270643 [Multi-domain]  Cd Length: 280  Bit Score: 49.00  E-value: 1.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQN-------VQFSEDTVRLYICEM-------ALALD 88
Cdd:cd05049   57 REAELLTNLQHENIVKFYGVCTEGDPLLMVFEYMEHGDLNKFLRSHgpdaaflASEDSAPGELTLSQLlhiavqiASGMV 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  89 YLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATII--KDGERataLAGTK--P--YMAPE--IFHSFvnggtgySFEVD 160
Cdd:cd05049  137 YLASQHFVHRDLATRNCLVGTNLVVKIGDFGMSRDIysTDYYR---VGGHTmlPirWMPPEsiLYRKF-------TTESD 206
                        170       180
                 ....*....|....*....|....*..
gi 247269852 161 WWSVGVMAYELLR-GWRPYDIHSSNAV 186
Cdd:cd05049  207 VWSFGVVLWEIFTyGKQPWFQLSNTEV 233
STKc_ACVR1_ALK1 cd14142
Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin ...
15-228 1.90e-06

Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR1, also called Activin receptor-Like Kinase 2 (ALK2), and ALK1 act as receptors for bone morphogenetic proteins (BMPs) and they activate SMAD1/5/8. ACVR1 is widely expressed while ALK1 is limited mainly to endothelial cells. The specificity of BMP binding to type I receptors is affected by type II receptors. ACVR1 binds BMP6/7/9/10 and can also bind anti-Mullerian hormone (AMH) in the presence of AMHR2. ALK1 binds BMP9/10 as well as TGFbeta in endothelial cells. A missense mutation in the GS domain of ACVR1 causes fibrodysplasia ossificans progressiva, a complex and disabling disease characterized by congenital skeletal malformations and extraskeletal bone formation. ACVR1 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors, and AMH, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like ACVR1 and ALK1, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The ACVR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271044 [Multi-domain]  Cd Length: 298  Bit Score: 48.98  E-value: 1.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  15 RDEvRNVFRELEILQEI----EHV--FLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLyICEMALALD 88
Cdd:cd14142   39 RDE-KSWFRETEIYNTVllrhENIlgFIASDMTSRNSCTQLWLITHYHENGSLYDYLQRTTLDHQEMLRL-ALSAASGLV 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  89 YLRSQ--------HIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALA-----GTKPYMAPEIFHSFVNGGTGY 155
Cdd:cd14142  117 HLHTEifgtqgkpAIAHRDLKSKNILVKSNGQCCIADLGLAVTHSQETNQLDVGnnprvGTKRYMAPEVLDETINTDCFE 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 156 SFE-VDWWSVGVMAYELLR---------GWRP--YDIHSSNAveSLVQLFSTVSV-QYVPT----WSKE-----MVALLR 213
Cdd:cd14142  197 SYKrVDIYAFGLVLWEVARrcvsggiveEYKPpfYDVVPSDP--SFEDMRKVVCVdQQRPNipnrWSSDptltaMAKLMK 274
                        250
                 ....*....|....*
gi 247269852 214 KLLTVNPEHRFSSLQ 228
Cdd:cd14142  275 ECWYQNPSARLTALR 289
PK_KSR cd14063
Pseudokinase domain of Kinase Suppressor of Ras; The pseudokinase domain shows similarity to ...
82-231 2.06e-06

Pseudokinase domain of Kinase Suppressor of Ras; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. KSR is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases, but there is some debate in this designation as a few groups have reported detecting kinase catalytic activity for KSRs, specifically KSR1. Vertebrates contain two KSR proteins, KSR1 and KSR2. The KSR subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270965 [Multi-domain]  Cd Length: 271  Bit Score: 48.50  E-value: 2.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDeQGHAHLTDF---NIATIIKDGERATALA---GTKPYMAPEI-----FHSFVN 150
Cdd:cd14063  105 QICQGMGYLHAKGIIHKDLKSKNIFLE-NGRVVITDFglfSLSGLLQPGRREDTLVipnGWLCYLAPEIiralsPDLDFE 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 151 GGTGYSFEVDWWSVGVMAYELLRGWRPYdihSSNAVESLV--------QLFSTVSVqyvptwSKEMVALLRKLLTVNPEH 222
Cdd:cd14063  184 ESLPFTKASDVYAFGTVWYELLAGRWPF---KEQPAESIIwqvgcgkkQSLSQLDI------GREVKDILMQCWAYDPEK 254
                        170
                 ....*....|.
gi 247269852 223 R--FSSLQDMQ 231
Cdd:cd14063  255 RptFSDLLRML 265
STKc_ACVR2 cd14053
Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor; STKs catalyze the ...
78-144 2.15e-06

Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR2 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors, such as ACVR2, are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. ACVR2 acts primarily as the receptors for activins, nodal, myostatin, GDF11, and a subset of BMPs. ACVR2 signaling impacts many cellular and physiological processes including reproductive and gonadal functions, myogenesis, bone remodeling and tooth development, kidney organogenesis, apoptosis, fibrosis, inflammation, and neurogenesis. Vertebrates contain two ACVR2 proteins, ACVR2a (or ActRIIA) and ACVR2b (or ActRIIB). The ACVR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270955 [Multi-domain]  Cd Length: 290  Bit Score: 48.86  E-value: 2.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  78 LYICE-MALALDYL-------RSQH---IIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE---RATALAGTKPYMAPE 143
Cdd:cd14053   95 CKIAEsMARGLAYLhedipatNGGHkpsIAHRDFKSKNVLLKSDLTACIADFGLALKFEPGKscgDTHGQVGTRRYMAPE 174

                 .
gi 247269852 144 I 144
Cdd:cd14053  175 V 175
PTKc_EphR_A2 cd05063
Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2; PTKs catalyze the ...
24-178 2.19e-06

Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The EphA2 receptor is overexpressed in tumor cells and tumor blood vessels in a variety of cancers including breast, prostate, lung, and colon. As a result, it is an attractive target for drug design since its inhibition could affect several aspects of tumor progression. EphRs comprise the largest subfamily of receptor PTKs (RTKs). Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. The EphA2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 133194 [Multi-domain]  Cd Length: 268  Bit Score: 48.43  E-value: 2.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  24 ELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDL-RYHLQQNVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKP 102
Cdd:cd05063   56 EASIMGQFSHHNIIRLEGVVTKFKPAMIITEYMENGALdKYLRDHDGEFSSYQLVGMLRGIAAGMKYLSDMNYVHRDLAA 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 103 DNILLDEQGHAHLTDFNIATIIKDGERA--TALAGTKP--YMAPEI--FHSFVNGGTGYSFEVDWWSvgVMAYellrGWR 176
Cdd:cd05063  136 RNILVNSNLECKVSDFGLSRVLEDDPEGtyTTSGGKIPirWTAPEAiaYRKFTSASDVWSFGIVMWE--VMSF----GER 209

                 ..
gi 247269852 177 PY 178
Cdd:cd05063  210 PY 211
PK_STRAD_alpha cd08227
Pseudokinase domain of STE20-related kinase adapter protein alpha; The pseudokinase domain ...
72-178 2.30e-06

Pseudokinase domain of STE20-related kinase adapter protein alpha; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. The structure of STRAD-alpha is available and shows that this protein binds ATP, has an ordered activation loop, and adopts a closed conformation typical of fully active protein kinases. It does not possess activity due to nonconservative substitutions of essential catalytic residues. ATP binding enhances the affinity of STRAD for MO25. The conformation of STRAD-alpha, stabilized through ATP and MO25, may be needed to activate LKB1. A mutation which results in a truncation of a C-terminal part of the human STRAD-alpha pseudokinase domain and disrupts its association with LKB1, leads to PMSE (polyhydramnios, megalencephaly, symptomatic epilepsy) syndrome. Several splice variants of STRAD-alpha exist which exhibit different effects on the localization and activation of LKB1. STRAD forms a complex with the scaffolding protein MO25, and the serine/threonine kinase (STK), LKB1, resulting in the activation of the kinase. In the complex, LKB1 phosphorylates and activates adenosine monophosphate-activated protein kinases (AMPKs), which regulate cell energy metabolism and cell polarity. The STRAD alpha subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173767 [Multi-domain]  Cd Length: 327  Bit Score: 48.79  E-value: 2.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  72 SEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDF-NIATIIKDGERATAL-------AGTKPYMAPE 143
Cdd:cd08227   99 SELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLrSNLSMINHGQRLRVVhdfpkysVKVLPWLSPE 178
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 247269852 144 IFHSFVNggtGYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd08227  179 VLQQNLQ---GYDAKSDIYSVGITACELANGHVPF 210
STKc_HIPK2 cd14227
Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2; ...
36-178 2.68e-06

Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HIPK2, the most studied HIPK, is a coregulator of many transcription factors and cofactors including homeodomain proteins (Nkx and HOX families), Smad1-4, Pax6, c-Myb, AML1, the histone acetyltransferase p300, and the tumor repressor p53, among others. It regulates gene transcription during development and in DNA damage response (DDR), and mediates cell processes such as apoptosis, survival, differentiation, and proliferation. HIPK2 mediates apoptosis by phosphorylating and activating p53 during DDR, resulting in the activation of apoptotic genes. In the absence of p53, HIPK2 targets the anti-apoptotic corepressor C-terminal binding protein (CtBP), leading to CtBP's degradation and the promotion of apoptosis. HIPKs, originally identified by their ability to bind homeobox factors, are nuclear proteins containing catalytic kinase and homeobox-interacting domains as well as a PEST region overlapping with the speckle-retention signal (SRS). The HIPK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271129 [Multi-domain]  Cd Length: 355  Bit Score: 48.93  E-value: 2.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  36 LVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQNvQFSE---DTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQG- 111
Cdd:cd14227   78 FVRAYECFQHKNHTCLVFEML-EQNLYDFLKQN-KFSPlplKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPSr 155
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 112 ---HAHLTDFNIATIIKDGERATALAgTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd14227  156 qpyRVKVIDFGSASHVSKAVCSTYLQ-SRYYRAPEIIL-----GLPFCEAIDMWSLGCVIAELFLGWPLY 219
STKc_TGFbR2_like cd14055
Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II ...
59-176 2.91e-06

Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TGFbR2 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors, such as TGFbR2, are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. TGFbR2 acts as the receptor for TGFbeta, which is crucial in growth control and homeostasis in many different tissues. It plays roles in regulating apoptosis and in maintaining the balance between self renewal and cell loss. It also plays a key role in maintaining vascular integrity and in regulating responses to genotoxic stress. Mutations in TGFbR2 can cause aortic aneurysm disorders such as Loeys-Dietz and Marfan syndromes. The TGFbR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270957 [Multi-domain]  Cd Length: 295  Bit Score: 48.53  E-value: 2.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  59 GDLRYHLQQNVQFSEDtvrlyICEMA--LA--LDYLRSQH---------IIHRDVKPDNILLDEQGHAHLTDFNIATIIK 125
Cdd:cd14055   84 GSLQDYLTRHILSWED-----LCKMAgsLArgLAHLHSDRtpcgrpkipIAHRDLKSSNILVKNDGTCVLADFGLALRLD 158
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 247269852 126 DGERATALA-----GTKPYMAPEIFHSFVNGGTGYSF-EVDWWSVGVMAYELLrgWR 176
Cdd:cd14055  159 PSLSVDELAnsgqvGTARYMAPEALESRVNLEDLESFkQIDVYSMALVLWEMA--SR 213
PTKc_Ror cd05048
Catalytic Domain of the Protein Tyrosine Kinases, Receptor tyrosine kinase-like Orphan ...
22-190 3.02e-06

Catalytic Domain of the Protein Tyrosine Kinases, Receptor tyrosine kinase-like Orphan Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Ror subfamily consists of Ror1, Ror2, and similar proteins. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. Ror kinases are expressed in many tissues during development. They play important roles in bone and heart formation. Mutations in human Ror2 result in two different bone development genetic disorders, recessive Robinow syndrome and brachydactyly type B. Drosophila Ror is expressed only in the developing nervous system during neurite outgrowth and neuronal differentiation, suggesting a role for Drosophila Ror in neural development. More recently, mouse Ror1 and Ror2 have also been found to play an important role in regulating neurite growth in central neurons. Ror1 and Ror2 are believed to have some overlapping and redundant functions. The Ror subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270642 [Multi-domain]  Cd Length: 283  Bit Score: 48.14  E-value: 3.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  22 FRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQN-------VQFSEDTVR--------LYIC-EMAL 85
Cdd:cd05048   56 RREAELMSDLQHPNIVCLLGVCTKEQPQCMLFEYMAHGDLHEFLVRHsphsdvgVSSDDDGTAssldqsdfLHIAiQIAA 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  86 ALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTK-P--YMAPE--IFHSFvnggtgySFEVD 160
Cdd:cd05048  136 GMEYLSSHHYVHRDLAARNCLVGDGLTVKISDFGLSRDIYSSDYYRVQSKSLlPvrWMPPEaiLYGKF-------TTESD 208
                        170       180       190
                 ....*....|....*....|....*....|.
gi 247269852 161 WWSVGVMAYELLR-GWRPYDIHSSNAVESLV 190
Cdd:cd05048  209 VWSFGVVLWEIFSyGLQPYYGYSNQEVIEMI 239
STKc_ACVR2b cd14140
Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor; STKs catalyze the ...
83-179 3.57e-06

Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR2b (or ActRIIB) belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. ACVR2b is one of two ACVR2 receptors found in vertebrates. Type II receptors are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. ACVR2 acts primarily as the receptors for activins, nodal, myostatin, GDF11, and a subset of BMPs. ACVR2 signaling impacts many cellular and physiological processes including reproductive and gonadal functions, myogenesis, bone remodeling and tooth development, kidney organogenesis, apoptosis, fibrosis, inflammation, and neurogenesis. The ACVR2b subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271042 [Multi-domain]  Cd Length: 291  Bit Score: 48.10  E-value: 3.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  83 MALALDYLRSQ-----------HIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE---RATALAGTKPYMAPEIFHSF 148
Cdd:cd14140  101 MARGLSYLHEDvprckgeghkpAIAHRDFKSKNVLLKNDLTAVLADFGLAVRFEPGKppgDTHGQVGTRRYMAPEVLEGA 180
                         90       100       110
                 ....*....|....*....|....*....|.
gi 247269852 149 VNGGTGYSFEVDWWSVGVMAYELLRGWRPYD 179
Cdd:cd14140  181 INFQRDSFLRIDMYAMGLVLWELVSRCKAAD 211
PTKc_TrkB cd05093
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B; PTKs catalyze ...
23-191 3.79e-06

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkB is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkB to its ligands, brain-derived neurotrophic factor (BDNF) or neurotrophin 4 (NT4), results in receptor oligomerization and activation of the catalytic domain. TrkB is broadly expressed in the nervous system and in some non-neural tissues. It plays important roles in cell proliferation, differentiation, and survival. BDNF/Trk signaling plays a key role in regulating activity-dependent synaptic plasticity. TrkB also contributes to protection against gp120-induced neuronal cell death. TrkB overexpression is associated with poor prognosis in neuroblastoma (NB) and other human cancers. It acts as a suppressor of anoikis (detachment-induced apoptosis) and contributes to tumor metastasis. The TrkB subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270675 [Multi-domain]  Cd Length: 288  Bit Score: 48.11  E-value: 3.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL-------------QQNVQFSEDTVRLYICEMALALDY 89
Cdd:cd05093   56 REAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLrahgpdavlmaegNRPAELTQSQMLHIAQQIAAGMVY 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  90 LRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTK---PYMAPE--IFHSFVNggtgysfEVDWWSV 164
Cdd:cd05093  136 LASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMlpiRWMPPEsiMYRKFTT-------ESDVWSL 208
                        170       180
                 ....*....|....*....|....*....
gi 247269852 165 GVMAYELLR-GWRP-YDIHSSNAVESLVQ 191
Cdd:cd05093  209 GVVLWEIFTyGKQPwYQLSNNEVIECITQ 237
PTKc_PDGFR_beta cd05107
Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor beta; ...
82-178 4.08e-06

Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor beta; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. PDGFR beta is a receptor PTK (RTK) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding to its ligands, the PDGFs, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR beta forms homodimers or heterodimers with PDGFR alpha, depending on the nature of the PDGF ligand. PDGF-BB and PDGF-DD induce PDGFR beta homodimerization. PDGFR signaling plays many roles in normal embryonic development and adult physiology. PDGFR beta signaling leads to a variety of cellular effects including the stimulation of cell growth and chemotaxis, as well as the inhibition of apoptosis and GAP junctional communication. It is critical in normal angiogenesis as it is involved in the recruitment of pericytes and smooth muscle cells essential for vessel stability. Aberrant PDGFR beta expression is associated with some human cancers. The continuously-active fusion proteins of PDGFR beta with COL1A1 and TEL are associated with dermatofibrosarcoma protuberans (DFSP) and a subset of chronic myelomonocytic leukemia (CMML), respectively. The PDGFR beta subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133238 [Multi-domain]  Cd Length: 401  Bit Score: 48.47  E-value: 4.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIA-TIIKDGERATALAGTKP--YMAPE-IFHSFvnggtgYSF 157
Cdd:cd05107  247 QVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLArDIMRDSNYISKGSTFLPlkWMAPEsIFNNL------YTT 320
                         90       100
                 ....*....|....*....|..
gi 247269852 158 EVDWWSVGVMAYELLR-GWRPY 178
Cdd:cd05107  321 LSDVWSFGILLWEIFTlGGTPY 342
STKc_HIPK1 cd14228
Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1; ...
36-178 5.18e-06

Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HIPK1 has been implicated in regulating eye size, lens formation, and retinal morphogenesis during late embryogenesis. It also contributes to the regulation of haematopoiesis and leukaemogenesis by phosphorylating and repressing the transcription factor c-Myb, which is crucial in T- and B-cell development. In glucose-deprived conditions, HIPK1 phosphorylates Daxx, leading to its relocalization from the nucleus to the cytoplasm, where it binds and stabilizes ASK1 (apoptosis signal-regulating kinase 1), a mitogen-activated protein kinase (MAPK) kinase kinase that activates the JNK and p38 MAPK pathways. HIPKs, originally identified by their ability to bind homeobox factors, are nuclear proteins containing catalytic kinase and homeobox-interacting domains as well as a PEST region overlapping with the speckle-retention signal (SRS). The HIPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271130 [Multi-domain]  Cd Length: 355  Bit Score: 47.78  E-value: 5.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  36 LVNLWYSFQDEEDMFMVVDLLlGGDLRYHLQQNvQFSE---DTVRLYICEMALALDYLRSQHIIHRDVKPDNILL----D 108
Cdd:cd14228   78 FVRSYECFQHKNHTCLVFEML-EQNLYDFLKQN-KFSPlplKYIRPILQQVATALMKLKSLGLIHADLKPENIMLvdpvR 155
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852 109 EQGHAHLTDFNIATIIKDGERATALAgTKPYMAPEIFHsfvngGTGYSFEVDWWSVGVMAYELLRGWRPY 178
Cdd:cd14228  156 QPYRVKVIDFGSASHVSKAVCSTYLQ-SRYYRAPEIIL-----GLPFCEAIDMWSLGCVIAELFLGWPLY 219
PTK_HER3 cd05111
Pseudokinase domain of the Protein Tyrosine Kinase, HER3; HER3 (ErbB3) is a member of the EGFR ...
51-178 6.51e-06

Pseudokinase domain of the Protein Tyrosine Kinase, HER3; HER3 (ErbB3) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. HER3 contains an impaired tyr kinase domain, which lacks crucial residues for catalytic activity against exogenous substrates but is still able to bind ATP and autophosphorylate. HER3 binds the neuregulin ligands, NRG1 and NRG2, and it relies on its heterodimerization partners for activity following ligand binding. The HER2-HER3 heterodimer constitutes a high affinity co-receptor capable of potent mitogenic signaling. HER3 participates in a signaling pathway involved in the proliferation, survival, adhesion, and motility of tumor cells. The HER3 subfamily is part of a larger superfamily that includes other pseudokinases and the the catalytic domains of active kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173656 [Multi-domain]  Cd Length: 279  Bit Score: 47.26  E-value: 6.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  51 MVVDLLLGGDLRYHLQQNVQFSEDTVRLYIC-EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGER 129
Cdd:cd05111   85 LVTQLLPLGSLLDHVRQHRGSLGPQLLLNWCvQIAKGMYYLEEHRMVHRNLAARNVLLKSPSQVQVADFGVADLLYPDDK 164
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 247269852 130 ATALAGTK---PYMAPEIFHSfvnggTGYSFEVDWWSVGVMAYELLR-GWRPY 178
Cdd:cd05111  165 KYFYSEAKtpiKWMALESIHF-----GKYTHQSDVWSYGVTVWEMMTfGAEPY 212
STKc_CK1_delta_epsilon cd14125
Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon; ...
40-126 6.70e-06

Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CK1 phosphorylates a variety of substrates including enzymes, transcription and splice factors, cytoskeletal proteins, viral oncogenes, receptors, and membrane-associated proteins. There are mutliple isoforms of CK1 and in mammals, seven isoforms (alpha, beta, gamma1-3, delta, and epsilon) have been characterized. These isoforms differ mainly in the length and structure of their C-terminal non-catalytic region. The delta and epsilon isoforms of CK1 play important roles in circadian rhythm and cell growth. They phosphorylate PERIOD proteins (PER1-3), which are circadian clock proteins that fulfill negative regulatory functions. PER phosphorylation leads to its degradation. However, CRY proteins form a complex with PER and CK1delta/epsilon that protects PER from degradation and leads to nuclear accummulation of the complex, which inhibits BMAL1-CLOCK dependent transcription activation. CK1delta/epsilon also phosphorylate the tumor suppressor p53 and the cellular oncogene Mdm2, which are key regulators of cell growth, genome integrity, and the development of cancer. This subfamily also includes the CK1 fungal proteins Saccharomyces cerevisiae HRR25 and Schizosaccharomyces pombe HHP1. These fungal proteins are involved in DNA repair. The CK1 delta/epsilon subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271027 [Multi-domain]  Cd Length: 275  Bit Score: 46.98  E-value: 6.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  40 WYSFQDEEDMfMVVDLLlGGDLRYHLQQ-NVQFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNIL--LDEQGH-AHL 115
Cdd:cd14125   63 WYGVEGDYNV-MVMDLL-GPSLEDLFNFcSRKFSLKTVLMLADQMISRIEYVHSKNFIHRDIKPDNFLmgLGKKGNlVYI 140
                         90
                 ....*....|.
gi 247269852 116 TDFNIATIIKD 126
Cdd:cd14125  141 IDFGLAKKYRD 151
STKc_BMPR1 cd14144
Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor; ...
49-173 7.15e-06

Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR1 functions as a receptor for morphogenetic proteins (BMPs), which are involved in the regulation of cell proliferation, survival, differentiation, and apoptosis. BMPs are able to induce bone, cartilage, ligament, and tendon formation, and may play roles in bone diseases and tumors. Vertebrates contain two type I BMP receptors, BMPR1a and BMPR1b. BMPR1 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that also includes TGFbeta, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like BMPR1, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The BMPR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271046 [Multi-domain]  Cd Length: 287  Bit Score: 47.09  E-value: 7.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  49 MFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYIcEMALALDYLRSQ--------HIIHRDVKPDNILLDEQGHAHLTDFNI 120
Cdd:cd14144   68 LYLITDYHENGSLYDFLRGNTLDTQSMLKLAY-SAACGLAHLHTEifgtqgkpAIAHRDIKSKNILVKKNGTCCIADLGL 146
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 247269852 121 AT-IIKDGERA----TALAGTKPYMAPEIFHSFVNGGTGYSFEV-DWWSVGVMAYELLR 173
Cdd:cd14144  147 AVkFISETNEVdlppNTRVGTKRYMAPEVLDESLNRNHFDAYKMaDMYSFGLVLWEIAR 205
PTKc_TAM cd05035
Catalytic Domain of TAM (Tyro3, Axl, Mer) Protein Tyrosine Kinases; PTKs catalyze the transfer ...
3-178 7.48e-06

Catalytic Domain of TAM (Tyro3, Axl, Mer) Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The TAM subfamily consists of Tyro3 (or Sky), Axl, Mer (or Mertk), and similar proteins. TAM subfamily members are receptor tyr kinases (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. TAM proteins are implicated in a variety of cellular effects including survival, proliferation, migration, and phagocytosis. They are also associated with several types of cancer as well as inflammatory, autoimmune, vascular, and kidney diseases. The TAM subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270631 [Multi-domain]  Cd Length: 273  Bit Score: 47.14  E-value: 7.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMnKQQCIERDEVRNVFRELEILQEIEH---VFLVNLWYSFQDEEDM---FMVVDLLLGGDLRYHL------QQNVQ 70
Cdd:cd05035   31 AVKTM-KVDIHTYSEIEEFLSEAACMKDFDHpnvMRLIGVCFTASDLNKPpspMVILPFMKHGDLHSYLlysrlgGLPEK 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  71 FSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE--RATALAGTK-PYMAPEIFHS 147
Cdd:cd05035  110 LPLQTLLKFMVDIAKGMEYLSNRNFIHRDLAARNCMLDENMTVCVADFGLSRKIYSGDyyRQGRISKMPvKWIALESLAD 189
                        170       180       190
                 ....*....|....*....|....*....|..
gi 247269852 148 FVnggtgYSFEVDWWSVGVMAYELL-RGWRPY 178
Cdd:cd05035  190 NV-----YTSKSDVWSFGVTMWEIAtRGQTPY 216
STKc_TGFbR_I cd14056
Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta family Type ...
95-173 1.06e-05

Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta family Type I Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of type I receptors for the TGFbeta family of secreted signaling molecules including TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation through trans-phosphorylation by type II receptors, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. They are inhibited by the immunophilin FKBP12, which is thought to control leaky signaling caused by receptor oligomerization in the absence of ligand. The TGFbR-I subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270958 [Multi-domain]  Cd Length: 287  Bit Score: 46.50  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  95 IIHRDVKPDNILLDEQGHAHLTDFNIA---------TIIKDGERAtalaGTKPYMAPEIFHSFVNGGTGYSFE-VDWWSV 164
Cdd:cd14056  121 IAHRDLKSKNILVKRDGTCCIADLGLAvrydsdtntIDIPPNPRV----GTKRYMAPEVLDDSINPKSFESFKmADIYSF 196

                 ....*....
gi 247269852 165 GVMAYELLR 173
Cdd:cd14056  197 GLVLWEIAR 205
PK_IRAK3 cd14160
Pseudokinase domain of Interleukin-1 Receptor Associated Kinase 3; The pseudokinase domain ...
2-176 1.12e-05

Pseudokinase domain of Interleukin-1 Receptor Associated Kinase 3; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain (a pseudokinase in the case of IRAK3), and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK3 (or IRAK-M) is the only IRAK that does not show kinase activity. It is found only in monocytes and macrophages in humans, and functions as a negative regulator of TLR signaling including TLR-2 induced p38 activation. It also negatively regulates the alternative NFkB pathway in a TLR-2 specific manner. IRAK3 is downregulated in the monocytes of obese people, and is associated with high SOD2, a marker of mitochondrial oxidative stress. It is an important inhibitor of inflammation in association with obesity and metabolic syndrome. The IRAK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271062 [Multi-domain]  Cd Length: 276  Bit Score: 46.42  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   2 YAMKYM---NKQQCieRDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNvqfSEDT--- 75
Cdd:cd14160   19 YAVKLFkqeKKMQW--KKHWKRFLSELEVLLLFQHPNILELAAYFTETEKFCLVYPYMQNGTLFDRLQCH---GVTKpls 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  76 --VRLYICE-MALALDYLRSQH---IIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGER-------ATALAGTKPYMAP 142
Cdd:cd14160   94 whERINILIgIAKAIHYLHNSQpctVICGNISSANILLDDQMQPKLTDFALAHFRPHLEDqsctinmTTALHKHLWYMPE 173
                        170       180       190
                 ....*....|....*....|....*....|....
gi 247269852 143 EifhsFVNGGTgYSFEVDWWSVGVMAYELLRGWR 176
Cdd:cd14160  174 E----YIRQGK-LSVKTDVYSFGIVIMEVLTGCK 202
PTKc_EphR_A cd05066
Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors; PTKs catalyze ...
6-178 1.12e-05

Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of most class EphA receptors including EphA3, EphA4, EphA5, and EphA7, but excluding EphA1, EphA2 and EphA10. Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. One exception is EphA4, which also binds ephrins-B2/B3. EphA receptors and ephrin-A ligands are expressed in multiple areas of the developing brain, especially in the retina and tectum. They are part of a system controlling retinotectal mapping. EphRs comprise the largest subfamily of receptor PTKs (RTKs). EphRs contain an ephrin-binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. The EphA subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270651 [Multi-domain]  Cd Length: 267  Bit Score: 46.40  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   6 YMNKQQcierdevRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQN-VQFSEDTVRLYICEMA 84
Cdd:cd05066   44 YTEKQR-------RDFLSEASIMGQFDHPNIIHLEGVVTRSKPVMIVTEYMENGSLDAFLRKHdGQFTVIQLVGMLRGIA 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  85 LALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERA--TALAGTKP--YMAPEI--FHSFVNGGtgysfe 158
Cdd:cd05066  117 SGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAayTTRGGKIPirWTAPEAiaYRKFTSAS------ 190
                        170       180
                 ....*....|....*....|.
gi 247269852 159 vDWWSVGVMAYELLR-GWRPY 178
Cdd:cd05066  191 -DVWSYGIVMWEVMSyGERPY 210
STKc_CK1_gamma cd14126
Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma; STKs catalyze ...
70-141 1.30e-05

Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CK1 phosphorylates a variety of substrates including enzymes, transcription and splice factors, cytoskeletal proteins, viral oncogenes, receptors, and membrane-associated proteins. There are mutliple isoforms of CK1 and in mammals, seven isoforms (alpha, beta, gamma1-3, delta, and epsilon) have been characterized. These isoforms differ mainly in the length and structure of their C-terminal non-catalytic region. CK1gamma proteins are unique within the CK1 subfamily in that they are palmitoylated at the C-termini and are anchored to the plasma membrane. CK1gamma is involved in transducing the signaling of LDL-receptor-related protein 6 (LRP6) through direct phosphorylation following Wnt stimulation, resulting in the recruitment of the scaffold protein Axin. In Xenopus embryos, CK1gamma is required during anterio-posterior patterning. In higher vertebrates, three CK1gamma (gamma1-3) isoforms exist. In mammalian cells, CK1gamma2 has been implicated in regulating the synthesis of sphingomyelin, a phospholipid that is found in the outer leaflet of the plasma membrane, by hyperphosphorylating and inactivating the ceramide transfer protein CERT. CK1gamma2 also phosphorylates the transcription factor Smad-3 resulting in its ubiquitination and degradation. It inhibits Smad-3 mediated responses of Transforming Growth Factor-beta (TGF-beta) including cell growth arrest. The CK1 gamma subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271028 [Multi-domain]  Cd Length: 288  Bit Score: 46.27  E-value: 1.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  70 QFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLDEQGHA-----HLTDFNIATIIKDGE--------RATALAGT 136
Cdd:cd14126   92 TFSLKTVLMIAIQLISRIEYVHSKHLIYRDVKPENFLIGRQSTKkqhviHIIDFGLAKEYIDPEtnkhipyrEHKSLTGT 171

                 ....*
gi 247269852 137 KPYMA 141
Cdd:cd14126  172 ARYMS 176
PTKc_TrkA cd05092
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A; PTKs catalyze ...
23-225 1.45e-05

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkA is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkA to its ligand, nerve growth factor (NGF), results in receptor oligomerization and activation of the catalytic domain. TrkA is expressed mainly in neural-crest-derived sensory and sympathetic neurons of the peripheral nervous system, and in basal forebrain cholinergic neurons of the central nervous system. It is critical for neuronal growth, differentiation and survival. Alternative TrkA splicing has been implicated as a pivotal regulator of neuroblastoma (NB) behavior. Normal TrkA expression is associated with better NB prognosis, while the hypoxia-regulated TrkAIII splice variant promotes NB pathogenesis and progression. Aberrant TrkA expression has also been demonstrated in non-neural tumors including prostate, breast, lung, and pancreatic cancers. The TrkA subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270674 [Multi-domain]  Cd Length: 280  Bit Score: 46.11  E-value: 1.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  23 RELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQ------------QNVQFSEDTVR--LYIC-EMALAL 87
Cdd:cd05092   56 REAELLTVLQHQHIVRFYGVCTEGEPLIMVFEYMRHGDLNRFLRshgpdakildggEGQAPGQLTLGqmLQIAsQIASGM 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  88 DYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERATALAGTK---PYMAPE--IFHSFVNggtgysfEVDWW 162
Cdd:cd05092  136 VYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMlpiRWMPPEsiLYRKFTT-------ESDIW 208
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 247269852 163 SVGVMAYELLR-GWRP-YDIHSSNAVESLVQLFSTVSVQYVPTwskEMVALLRKLLTVNPEHRFS 225
Cdd:cd05092  209 SFGVVLWEIFTyGKQPwYQLSNTEAIECITQGRELERPRTCPP---EVYAIMQGCWQREPQQRHS 270
PTKc_Ror2 cd05091
Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor ...
14-191 1.66e-05

Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Ror2 plays important roles in skeletal and heart formation. Ror2-deficient mice show widespread bone abnormalities, ventricular defects in the heart, and respiratory dysfunction. Mutations in human Ror2 result in two different bone development genetic disorders, recessive Robinow syndrome and brachydactyly type B. Ror2 is also implicated in neural development. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The Ror2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270673 [Multi-domain]  Cd Length: 284  Bit Score: 46.16  E-value: 1.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  14 ERDEV--RNVFRELEILQ-EIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL-----QQNVQFSED--TVR------ 77
Cdd:cd05091   46 DKAEGplREEFRHEAMLRsRLQHPNIVCLLGVVTKEQPMSMIFSYCSHGDLHEFLvmrspHSDVGSTDDdkTVKstlepa 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  78 --LYI-CEMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGERaTALAGTKP----YMAPEifhSFVN 150
Cdd:cd05091  126 dfLHIvTQIAAGMEYLSSHHVVHKDLATRNVLVFDKLNVKISDLGLFREVYAADY-YKLMGNSLlpirWMSPE---AIMY 201
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 247269852 151 GgtGYSFEVDWWSVGVMAYELLR-GWRPYDIHSSNAVESLVQ 191
Cdd:cd05091  202 G--KFSIDSDIWSYGVVLWEVFSyGLQPYCGYSNQDVIEMIR 241
PTKc_CSF-1R cd05106
Catalytic domain of the Protein Tyrosine Kinase, Colony-Stimulating Factor-1 Receptor; PTKs ...
82-178 1.83e-05

Catalytic domain of the Protein Tyrosine Kinase, Colony-Stimulating Factor-1 Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. CSF-1R, also called c-Fms, is a member of the Platelet Derived Growth Factor Receptor (PDGFR) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of CSF-1R to its ligand, CSF-1, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. CSF-1R signaling is critical in the regulation of macrophages and osteoclasts. It leads to increases in gene transcription and protein translation, and induces cytoskeletal remodeling. CSF-1R signaling leads to a variety of cellular responses including survival, proliferation, and differentiation of target cells. It plays an important role in innate immunity, tissue development and function, and the pathogenesis of some diseases including atherosclerosis and cancer. CSF-1R signaling is also implicated in mammary gland development during pregnancy and lactation. Aberrant CSF-1/CSF-1R expression correlates with tumor cell invasiveness, poor clinical prognosis, and bone metastasis in breast cancer. Although the structure of the human CSF-1R catalytic domain is known, it is excluded from this specific alignment model because it contains a deletion in its sequence. The CSF-1R subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133237 [Multi-domain]  Cd Length: 374  Bit Score: 46.38  E-value: 1.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIA-TIIKDGERATALAGTKP--YMAPE-IFHSFvnggtgYSF 157
Cdd:cd05106  220 QVAQGMDFLASKNCIHRDVAARNVLLTDGRVAKICDFGLArDIMNDSNYVVKGNARLPvkWMAPEsIFDCV------YTV 293
                         90       100
                 ....*....|....*....|..
gi 247269852 158 EVDWWSVGVMAYELLR-GWRPY 178
Cdd:cd05106  294 QSDVWSYGILLWEIFSlGKSPY 315
PTKc_Ack_like cd05040
Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase; PTKs ...
3-128 2.96e-05

Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily includes Ack1, thirty-eight-negative kinase 1 (Tnk1), and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing an N-terminal catalytic domain, an SH3 domain, a Cdc42-binding CRIB domain, and a proline-rich region. They are mainly expressed in brain and skeletal tissues and are involved in the regulation of cell adhesion and growth, receptor degradation, and axonal guidance. Ack1 is also associated with androgen-independent prostate cancer progression. Tnk1 regulates TNFalpha signaling and may play an important role in cell death. The Ack-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270636 [Multi-domain]  Cd Length: 258  Bit Score: 45.03  E-value: 2.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852   3 AMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLwYSFQDEEDMFMVVDLLLGGDLRYHLQQNV-QFSEDTVRLYIC 81
Cdd:cd05040   27 AVKCLKSDVLSQPNAMDDFLKEVNAMHSLDHPNLIRL-YGVVLSSPLMMVTELAPLGSLLDRLRKDQgHFLISTLCDYAV 105
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDEQGHAHLTDFNIATIIKDGE 128
Cdd:cd05040  106 QIANGMAYLESKRFIHRDLAARNILLASKDKVKIGDFGLMRALPQNE 152
STKc_VRK cd14015
Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase; STKs ...
43-121 3.07e-05

Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. VRKs were initially discovered due to its similarity to vaccinia virus B1R STK, which is important for viral replication. They play important roles in cell signaling, nuclear envelope dynamics, apoptosis, and stress responses. Vertebrates contain three VRK proteins (VRK1, VRK2, and VRK3) while invertebrates, specifically fruit flies and nematodes, seem to carry only a single ortholog. Mutations of VRK in Drosophila and Caenorhabditis elegans showed varying phenotypes ranging from embryonic lethality to mitotic and meiotic defects resulting in sterility. In vertebrates, VRK1 is implicated in cell cycle progression and proliferation, nuclear envelope assembly, and chromatin condensation. VRK2 is involved in modulating JNK signaling. VRK3 is an inactive pseudokinase that inhibits ERK signaling. The VRK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270917 [Multi-domain]  Cd Length: 300  Bit Score: 45.35  E-value: 3.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  43 FQDEEDMFMVVDLLlGGDLRYHLQQNV-QFSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILLD---EQGHAHLTDF 118
Cdd:cd14015   96 YKGEKYRFLVMPRF-GRDLQKIFEKNGkRFPEKTVLQLALRILDVLEYIHENGYVHADIKASNLLLGfgkNKDQVYLVDY 174

                 ...
gi 247269852 119 NIA 121
Cdd:cd14015  175 GLA 177
PKc_CLK2 cd14215
Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2; Dual-specificity ...
71-183 3.32e-05

Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. CLK2 plays a role in hepatic insulin signaling and glucose metabolism. It is induced by the insulin/Akt pathway as part of the hepatic refeeding reponse, and it directly phosphorylates the SR domain of PGC-1alpha, which results in decreased gluconeogenic gene expression and glucose output. CLKs are involved in the phosphorylation and regulation of serine/arginine-rich (SR) proteins, which play a crucial role in pre-mRNA splicing by directing splice site selection. SR proteins are phosphorylated first by SR protein kinases (SRPKs) at the N-terminus, which leads to its assembly into nuclear speckles where splicing factors are stored. CLKs phosphorylate the C-terminal part of SR proteins, causing the nuclear speckles to dissolve and splicing factors to be recruited at sites of active transcription. Based on a conserved "EHLAMMERILG" signature motif which may be crucial for substrate specificity, CLKs are also referred to as LAMMER kinases. CLKs autophosphorylate at tyrosine residues and phosphorylate their substrates exclusively on serine/threonine residues. The CLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271117 [Multi-domain]  Cd Length: 330  Bit Score: 45.39  E-value: 3.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  71 FSEDTVRLYICEMALALDYLRSQHIIHRDVKPDNILL---------------DEQG----HAHLTDFNIATIikDGERAT 131
Cdd:cd14215  113 YPIHQVRHMAFQVCQAVKFLHDNKLTHTDLKPENILFvnsdyeltynlekkrDERSvkstAIRVVDFGSATF--DHEHHS 190
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 247269852 132 ALAGTKPYMAPEIFHSFvnggtGYSFEVDWWSVGVMAYELLRGWRPYDIHSS 183
Cdd:cd14215  191 TIVSTRHYRAPEVILEL-----GWSQPCDVWSIGCIIFEYYVGFTLFQTHDN 237
STKc_TGFbR1_ACVR1b_ACVR1c cd14143
Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I ...
15-173 3.47e-05

Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TGFbR1, also called Activin receptor-Like Kinase 5 (ALK5), functions as a receptor for TGFbeta and phoshorylates SMAD2/3. TGFbeta proteins are cytokines that regulate cell growth, differentiation, and survival, and are critical in the development and progression of many human cancers. Mutations in TGFbR1 (and TGFbR2) can cause aortic aneurysm disorders such as Loeys-Dietz and Marfan syndromes. ACVR1b (also called ALK4) and ACVR1c (also called ALK7) act as receptors for activin A and B, respectively. TGFbR1, ACVR1b, and ACVR1c belong to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like TGFbR1, ACVR1b, and ACVR1c, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The TGFbR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271045 [Multi-domain]  Cd Length: 288  Bit Score: 45.13  E-value: 3.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  15 RDEvRNVFRELEILQEI----EHVflvnLWYSFQDEED------MFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYI---C 81
Cdd:cd14143   29 REE-RSWFREAEIYQTVmlrhENI----LGFIAADNKDngtwtqLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALsiaS 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMA-LALDYLRSQ---HIIHRDVKPDNILLDEQGHAHLTDFNIA--------TI-IKDGERatalAGTKPYMAPEIFHSF 148
Cdd:cd14143  104 GLAhLHMEIVGTQgkpAIAHRDLKSKNILVKKNGTCCIADLGLAvrhdsatdTIdIAPNHR----VGTKRYMAPEVLDDT 179
                        170       180
                 ....*....|....*....|....*.
gi 247269852 149 VNGGTGYSFE-VDWWSVGVMAYELLR 173
Cdd:cd14143  180 INMKHFESFKrADIYALGLVFWEIAR 205
PTKc_EphR_B cd05065
Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors; PTKs catalyze ...
19-191 3.70e-05

Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Class EphB receptors bind to transmembrane ephrin-B ligands. There are six vertebrate EphB receptors (EphB1-6), which display promiscuous interactions with three ephrin-B ligands. One exception is EphB2, which also interacts with ephrin A5. EphB receptors play important roles in synapse formation and plasticity, spine morphogenesis, axon guidance, and angiogenesis. In the intestinal epithelium, EphBs are Wnt signaling target genes that control cell compartmentalization. They function as suppressors of colon cancer progression. EphRs comprise the largest subfamily of receptor PTKs (RTKs). They contain an ephrin-binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion. The EphB subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173638 [Multi-domain]  Cd Length: 269  Bit Score: 44.86  E-value: 3.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  19 RNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNV-QFSEDTVRLYICEMALALDYLRSQHIIH 97
Cdd:cd05065   50 RDFLSEASIMGQFDHPNIIHLEGVVTKSRPVMIITEFMENGALDSFLRQNDgQFTVIQLVGMLRGIAAGMKYLSEMNYVH 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  98 RDVKPDNILLDEQGHAHLTDFNIATIIKDGER----ATALAGTKP--YMAPEI--FHSFVNGGtgysfevDWWSVGVMAY 169
Cdd:cd05065  130 RDLAARNILVNSNLVCKVSDFGLSRFLEDDTSdptyTSSLGGKIPirWTAPEAiaYRKFTSAS-------DVWSYGIVMW 202
                        170       180
                 ....*....|....*....|....
gi 247269852 170 ELLR-GWRPY-DIHSSNAVESLVQ 191
Cdd:cd05065  203 EVMSyGERPYwDMSNQDVINAIEQ 226
PK_KSR2 cd14153
Pseudokinase domain of Kinase Suppressor of Ras 2; The pseudokinase domain shows similarity to ...
82-186 4.72e-05

Pseudokinase domain of Kinase Suppressor of Ras 2; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. KSR2 interacts with the protein phosphatase calcineurin and functions in calcium-mediated ERK signaling. It also functions in energy metabolism by regulating AMP kinase and AMPK-dependent processes such as glucose uptake and fatty acid oxidation. KSR proteins act as scaffold proteins that function downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases. The KSR2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271055 [Multi-domain]  Cd Length: 270  Bit Score: 44.61  E-value: 4.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  82 EMALALDYLRSQHIIHRDVKPDNILLDeQGHAHLTDFNIATI---IKDGERATAL---AGTKPYMAPEIFHSF----VNG 151
Cdd:cd14153  105 EIVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFTIsgvLQAGRREDKLriqSGWLCHLAPEIIRQLspetEED 183
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 247269852 152 GTGYSFEVDWWSVGVMAYEL-LRGWrPYDIHSSNAV 186
Cdd:cd14153  184 KLPFSKHSDVFAFGTIWYELhAREW-PFKTQPAEAI 218
PK_TRB1 cd14023
Pseudokinase domain of Tribbles Homolog 1; The pseudokinase domain shows similarity to protein ...
19-226 5.09e-05

Pseudokinase domain of Tribbles Homolog 1; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. TRB1 interacts directly with the mitogen activated protein kinase (MAPK) kinase MKK4, an activator of JNK. It regulates vascular smooth muscle cell proliferation and chemotaxis through the JNK signaling pathway. It is found to be down-regulated in human acute myeloid leukaemia (AML) and may play a role in the pathogenesis of the disease. It has also been identified as a potential biomarker for antibody-mediated allograft failure. TRB1 is one of three Tribbles Homolog (TRB) proteins present in vertebrates that are encoded by three separate genes. TRB proteins interact with many proteins involved in signalling pathways. They play scaffold-like regulatory functions and affect many cellular processes such as mitosis, apoptosis, and gene expression. The TRB1 subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270925 [Multi-domain]  Cd Length: 242  Bit Score: 44.27  E-value: 5.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  19 RNVFRELEILQEIEHVFLVNLWYSFQDEEDMFM----------VVDLLLG------------GDLRYHLQQNVQFSEDTV 76
Cdd:cd14023    7 EHVYRALQLHSGAELQCKVFPLKHYQDKIRPYIqlpshrnitgIVEVILGdtkayvffekdfGDMHSYVRSCKRLREEEA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247269852  77 RLYICEMALALDYLRSQHIIHRDVKPDNILL--DEQGHAHLTDFNIATIIKDGERATA-LAGTKPYMAPEIFHSfvnGGT 153
Cdd:cd14023   87 ARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFsdEERTQLRLESLEDTHIMKGEDDALSdKHGCPAYVSPEILNT---TGT 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247269852 154 GYSFEVDWWSVGVMAYELLRGWRPYdiHSSNAveslVQLFSTVSV-QY-VPTW-SKEMVALLRKLLTVNPEHRFSS 226
Cdd:cd14023  164 YSGKSADVWSLGVMLYTLLVGRYPF--HDSDP----SALFSKIRRgQFcIPDHvSPKARCLIRSLLRREPSERLTA 233
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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