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Conserved domains on  [gi|239050405|ref|NP_001155082|]
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interferon zeta-like precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IFab super family cl00092
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon ...
 41-165 2.30e-28

Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. Interferons produce antiviral and antiproliferative responses in cells. Receptor specificity determines function of the various members of the family.


The actual alignment was detected with superfamily member cd00095:

Pssm-ID: 469611  Cd Length: 152  Bit Score: 103.18  E-value: 2.30e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050405  41 LAELRSVPGHQCLRDRTDFPCPWkEGTNITPMTLGETTSCYSQTLRQVLHLFDTEASRAAWHERALDQLLSSLWRELQVL 120
Cdd:cd00095   16 LRQMRRLPPQSCLKDRADFGFPQ-ELLQGDQFQKAQAASVLHEMLQQIFNIFSTPSSSAAWNETLLESLLNELHQQLNHL 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 239050405 121 KRPREQGQSC-----PLPFALAIRTYFRGFFRYLKAKAHSACSWEIVRVQ 165
Cdd:cd00095   95 ETCLEQEMGEeetpgPRNTHLHLRKYFQRIQLYLKEKKYSPCAWEVVRAE 144
 
Name Accession Description Interval E-value
IFab cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon ...
 41-165 2.30e-28

Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. Interferons produce antiviral and antiproliferative responses in cells. Receptor specificity determines function of the various members of the family.


Pssm-ID: 238047  Cd Length: 152  Bit Score: 103.18  E-value: 2.30e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050405  41 LAELRSVPGHQCLRDRTDFPCPWkEGTNITPMTLGETTSCYSQTLRQVLHLFDTEASRAAWHERALDQLLSSLWRELQVL 120
Cdd:cd00095   16 LRQMRRLPPQSCLKDRADFGFPQ-ELLQGDQFQKAQAASVLHEMLQQIFNIFSTPSSSAAWNETLLESLLNELHQQLNHL 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 239050405 121 KRPREQGQSC-----PLPFALAIRTYFRGFFRYLKAKAHSACSWEIVRVQ 165
Cdd:cd00095   95 ETCLEQEMGEeetpgPRNTHLHLRKYFQRIQLYLKEKKYSPCAWEVVRAE 144
Interferon pfam00143
Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical ...
 29-166 1.50e-27

Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily,which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules.


Pssm-ID: 459689  Cd Length: 160  Bit Score: 101.12  E-value: 1.50e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050405   29 SLHLERS--ETARFLAELRSVPGHQCLRDRTDFPCPwKEGTNITPMTLGETTSCYSQTLRQVLHLFDTEASRAAWHERAL 106
Cdd:pfam00143   2 PQQLRLSnrENLKLLNQMRRSSPQSCLKDRKDFKFP-QEILSGSQLQKEQAALVLHEMLQQIFNLFSTNHSSAAWNETLL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 239050405  107 DQLLSSLWRELQVLK---RPREQGQSCPLPF---ALAIRTYFRGFFRYLKAKAHSACSWEIVRVQL 166
Cdd:pfam00143  81 EQLLNGLHQQLEDLEtclGEEMEEEESPLGNedsRLALKKYFQRIHLYLKEKEYSSCAWEVVRVEI 146
IFabd smart00076
Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative ...
 58-165 5.54e-20

Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon.


Pssm-ID: 197503  Cd Length: 117  Bit Score: 80.43  E-value: 5.54e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050405    58 DFPCPWkEGTNITPMTLGETTSCYSQTLRQVLHLFDTEASRAAWHERALDQLLSSLWRELQVLKRPREQGQSC-----PL 132
Cdd:smart00076   1 DFAFPE-EILDGSQFQKAQAASVIHEMLQQIFNIFSSPSSSAAWNETLLESLLNELHQQLNHLEACLKQQMGEeetplTR 79

                           90       100       110
                   ....*....|....*....|....*....|...
gi 239050405   133 PFALAIRTYFRGFFRYLKAKAHSACSWEIVRVQ 165
Cdd:smart00076  80 NTHLALKKYFQRIQLYLKEKKYSPCAWEVVRVE 112
 
Name Accession Description Interval E-value
IFab cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon ...
 41-165 2.30e-28

Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. Interferons produce antiviral and antiproliferative responses in cells. Receptor specificity determines function of the various members of the family.


Pssm-ID: 238047  Cd Length: 152  Bit Score: 103.18  E-value: 2.30e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050405  41 LAELRSVPGHQCLRDRTDFPCPWkEGTNITPMTLGETTSCYSQTLRQVLHLFDTEASRAAWHERALDQLLSSLWRELQVL 120
Cdd:cd00095   16 LRQMRRLPPQSCLKDRADFGFPQ-ELLQGDQFQKAQAASVLHEMLQQIFNIFSTPSSSAAWNETLLESLLNELHQQLNHL 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 239050405 121 KRPREQGQSC-----PLPFALAIRTYFRGFFRYLKAKAHSACSWEIVRVQ 165
Cdd:cd00095   95 ETCLEQEMGEeetpgPRNTHLHLRKYFQRIQLYLKEKKYSPCAWEVVRAE 144
Interferon pfam00143
Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical ...
 29-166 1.50e-27

Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily,which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules.


Pssm-ID: 459689  Cd Length: 160  Bit Score: 101.12  E-value: 1.50e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050405   29 SLHLERS--ETARFLAELRSVPGHQCLRDRTDFPCPwKEGTNITPMTLGETTSCYSQTLRQVLHLFDTEASRAAWHERAL 106
Cdd:pfam00143   2 PQQLRLSnrENLKLLNQMRRSSPQSCLKDRKDFKFP-QEILSGSQLQKEQAALVLHEMLQQIFNLFSTNHSSAAWNETLL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 239050405  107 DQLLSSLWRELQVLK---RPREQGQSCPLPF---ALAIRTYFRGFFRYLKAKAHSACSWEIVRVQL 166
Cdd:pfam00143  81 EQLLNGLHQQLEDLEtclGEEMEEEESPLGNedsRLALKKYFQRIHLYLKEKEYSSCAWEVVRVEI 146
IFabd smart00076
Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative ...
 58-165 5.54e-20

Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon.


Pssm-ID: 197503  Cd Length: 117  Bit Score: 80.43  E-value: 5.54e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239050405    58 DFPCPWkEGTNITPMTLGETTSCYSQTLRQVLHLFDTEASRAAWHERALDQLLSSLWRELQVLKRPREQGQSC-----PL 132
Cdd:smart00076   1 DFAFPE-EILDGSQFQKAQAASVIHEMLQQIFNIFSSPSSSAAWNETLLESLLNELHQQLNHLEACLKQQMGEeetplTR 79

                           90       100       110
                   ....*....|....*....|....*....|...
gi 239050405   133 PFALAIRTYFRGFFRYLKAKAHSACSWEIVRVQ 165
Cdd:smart00076  80 NTHLALKKYFQRIQLYLKEKKYSPCAWEVVRVE 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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