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Conserved domains on  [gi|238478338|ref|NP_001154302|]
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Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

Protein Classification

HAT repeat-containing protein( domain architecture ID 10647625)

HAT (Half-A-TPR) repeat-containing protein similar to Candida albicans pre-mRNA-splicing factor CLF1 that is involved in pre-mRNA splicing and cell cycle progression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HAT smart00386
HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and ...
 189-221 5.17e-04

HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and sequentially thought to be similar to TPRs.


:

Pssm-ID: 214642 [Multi-domain]  Cd Length: 33  Bit Score: 37.53  E-value: 5.17e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 238478338   189 GDFNKVVKLYERCVVTCANYPEYWIRYVTNMEA 221
Cdd:smart00386   1 GDIERARKIYERALEKFPKSVELWLKYAEFEER 33
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 186-307 8.54e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 8.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478338 186 ERDGDFNKVVKLYERCVVTCANYPEYWIRYVTNMEASGSADLAENALARATQVFvKKQPEIHLFAARLKEQNGDIAGARA 265
Cdd:COG4783   15 LLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELD-PDEPEARLNLGLALLKAGDYDEALA 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 238478338 266 AYQLVHsEISPGLLEAVIKHANMEYRLGNLDDAFSLYEQVIA 307
Cdd:COG4783   94 LLEKAL-KLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134
 
Name Accession Description Interval E-value
HAT smart00386
HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and ...
 189-221 5.17e-04

HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and sequentially thought to be similar to TPRs.


Pssm-ID: 214642 [Multi-domain]  Cd Length: 33  Bit Score: 37.53  E-value: 5.17e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 238478338   189 GDFNKVVKLYERCVVTCANYPEYWIRYVTNMEA 221
Cdd:smart00386   1 GDIERARKIYERALEKFPKSVELWLKYAEFEER 33
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 186-307 8.54e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 8.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478338 186 ERDGDFNKVVKLYERCVVTCANYPEYWIRYVTNMEASGSADLAENALARATQVFvKKQPEIHLFAARLKEQNGDIAGARA 265
Cdd:COG4783   15 LLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELD-PDEPEARLNLGLALLKAGDYDEALA 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 238478338 266 AYQLVHsEISPGLLEAVIKHANMEYRLGNLDDAFSLYEQVIA 307
Cdd:COG4783   94 LLEKAL-KLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 223-355 3.60e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.45  E-value: 3.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478338  223 GSADLAENALARATQVF---VKKQPEiHLFA----ARLKEQNGDIAGARAAYQLVhSEISPGLLEAVIKHANMEYRLGNL 295
Cdd:TIGR02917 472 GAIYLGKGDLAKAREAFekaLSIEPD-FFPAaanlARIDIQEGNPDDAIQRFEKV-LTIDPKNLRAILALAGLYLRTGNE 549

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478338  296 DDAFSLYEQVIAVEKGKEHstiLPLLYAQYsrfsYLVSRDAEKARRIIVEALDhVQPSKP 355
Cdd:TIGR02917 550 EEAVAWLEKAAELNPQEIE---PALALAQY----YLGKGQLKKALAILNEAAD-AAPDSP 601
 
Name Accession Description Interval E-value
HAT smart00386
HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and ...
 189-221 5.17e-04

HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and sequentially thought to be similar to TPRs.


Pssm-ID: 214642 [Multi-domain]  Cd Length: 33  Bit Score: 37.53  E-value: 5.17e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 238478338   189 GDFNKVVKLYERCVVTCANYPEYWIRYVTNMEA 221
Cdd:smart00386   1 GDIERARKIYERALEKFPKSVELWLKYAEFEER 33
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 186-307 8.54e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 8.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478338 186 ERDGDFNKVVKLYERCVVTCANYPEYWIRYVTNMEASGSADLAENALARATQVFvKKQPEIHLFAARLKEQNGDIAGARA 265
Cdd:COG4783   15 LLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELD-PDEPEARLNLGLALLKAGDYDEALA 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 238478338 266 AYQLVHsEISPGLLEAVIKHANMEYRLGNLDDAFSLYEQVIA 307
Cdd:COG4783   94 LLEKAL-KLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 219-309 1.76e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.13  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478338 219 MEASGSADLAENALARATQVFVKKQPEIHLFAARLKEQnGDIAGARAAYQLVHsEISPGLLEAVIKHANMEYRLGNLDDA 298
Cdd:COG3914   88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLLAL-GRLEEALAALRRAL-ALNPDFAEAYLNLGEALRRLGRLEEA 165

                         90
                 ....*....|.
gi 238478338 299 FSLYEQVIAVE 309
Cdd:COG3914  166 IAALRRALELD 176
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 223-355 3.60e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.45  E-value: 3.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478338  223 GSADLAENALARATQVF---VKKQPEiHLFA----ARLKEQNGDIAGARAAYQLVhSEISPGLLEAVIKHANMEYRLGNL 295
Cdd:TIGR02917 472 GAIYLGKGDLAKAREAFekaLSIEPD-FFPAaanlARIDIQEGNPDDAIQRFEKV-LTIDPKNLRAILALAGLYLRTGNE 549

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478338  296 DDAFSLYEQVIAVEKGKEHstiLPLLYAQYsrfsYLVSRDAEKARRIIVEALDhVQPSKP 355
Cdd:TIGR02917 550 EEAVAWLEKAAELNPQEIE---PALALAQY----YLGKGQLKKALAILNEAAD-AAPDSP 601
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 186-382 3.72e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 3.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478338 186 ERDGDFNKVVKLYERCVVTCANYPEYWIRYVTNMEASGSADLAENALARATQVfVKKQPEIHLFAARLKEQNGDIAGARA 265
Cdd:COG2956   53 RRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLEL-DPDDAEALRLLAEIYEQEGDWEKAIE 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478338 266 AYQLVhSEISPGLLEAVIKHANMEYRLGNLDDAFSLYEQVIAVEKGKEHSTilpLLYAQYsrfsYLVSRDAEKARRIIVE 345
Cdd:COG2956  132 VLERL-LKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARAL---LLLAEL----YLEQGDYEEAIAALER 203

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 238478338 346 ALDHVQPSKPLMEALIH-FEAIQPPPREIDYLEPLVEK 382
Cdd:COG2956  204 ALEQDPDYLPALPRLAElYEKLGDPEEALELLRKALEL 241
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 189-286 5.45e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 37.29  E-value: 5.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478338 189 GDFNKVVKLYERCVVTCANYPEYWIRYVTNMEASGSADLAENALARATQVfVKKQPEIHLFAARLKEQNGDIAGARAAYQ 268
Cdd:COG4235   31 GRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL-DPDNPEALYLLGLAAFQQGDYAEAIAAWQ 109

                         90
                 ....*....|....*...
gi 238478338 269 LVHSEISPGLLEAVIKHA 286
Cdd:COG4235  110 KLLALLPADAPARLLEAS 127
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 207-308 7.76e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.91  E-value: 7.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478338 207 NYPEYWIRYVTNMEASGSADLAENALARATQvFVKKQPEIHLFAARLKEQNGDIAGARAAYQLVHsEISPGLLEAVIKHA 286
Cdd:COG4235   15 NDAEGWLLLGRAYLRLGRYDEALAAYEKALR-LDPDNADALLDLAEALLAAGDTEEAEELLERAL-ALDPDNPEALYLLG 92

                         90       100
                 ....*....|....*....|..
gi 238478338 287 NMEYRLGNLDDAFSLYEQVIAV 308
Cdd:COG4235   93 LAAFQQGDYAEAIAAWQKLLAL 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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