histone deacetylase [Arabidopsis thaliana]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Arginase_HDAC super family | cl17011 | Arginase-like and histone-like hydrolases; Arginase-like/histone-like hydrolase superfamily ... |
12-50 | 3.60e-05 | ||
Arginase-like and histone-like hydrolases; Arginase-like/histone-like hydrolase superfamily includes metal-dependent enzymes that belong to Arginase-like amidino hydrolase family and histone/histone-like deacetylase class I, II, IV family, respectively. These enzymes catalyze hydrolysis of amide bond. Arginases are known to be involved in control of cellular levels of arginine and ornithine, in histidine and arginine degradation and in clavulanic acid biosynthesis. Deacetylases play a role in signal transduction through histone and/or other protein modification and can repress/activate transcription of a number of different genes. They participate in different cellular processes including cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and post-translational control of the acetyl coenzyme A synthetase. Mammalian histone deacetyases are known to be involved in progression of different tumors. Specific inhibitors of mammalian histone deacetylases are an emerging class of promising novel anticancer drugs. The actual alignment was detected with superfamily member pfam00850: Pssm-ID: 450134 [Multi-domain] Cd Length: 298 Bit Score: 39.14 E-value: 3.60e-05
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| Name | Accession | Description | Interval | E-value | ||
| Hist_deacetyl | pfam00850 | Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. ... |
12-50 | 3.60e-05 | ||
Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is caused in part by this mechanism. Histone deacetylases catalyze the removal of the acetyl group. Histone deacetylases are related to other proteins. Pssm-ID: 425906 [Multi-domain] Cd Length: 298 Bit Score: 39.14 E-value: 3.60e-05
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| HDAC_classII_2 | cd11599 | Histone deacetylases and histone-like deacetylases, classII; This subfamily includes ... |
12-50 | 5.83e-04 | ||
Histone deacetylases and histone-like deacetylases, classII; This subfamily includes eukaryotic as well as bacterial Class II histone deacetylase (HDAC) and related proteins. Deacetylases of class II are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. In D. discoideum, where four homologs (HdaA, HdaB, HdaC, HdaD) have been identified, HDAC activity is important for regulating the timing of gene expression during development. Also, inhibition of HDAC activity by trichostatin A is shown to cause hyperacetylation of the histone and a delay in cell aggregation and differentiation. Pssm-ID: 212541 [Multi-domain] Cd Length: 288 Bit Score: 35.95 E-value: 5.83e-04
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| AcuC | COG0123 | Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites ... |
11-34 | 3.62e-03 | ||
Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites biosynthesis, transport and catabolism]; Pssm-ID: 439893 [Multi-domain] Cd Length: 308 Bit Score: 33.54 E-value: 3.62e-03
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| Name | Accession | Description | Interval | E-value | ||
| Hist_deacetyl | pfam00850 | Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. ... |
12-50 | 3.60e-05 | ||
Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is caused in part by this mechanism. Histone deacetylases catalyze the removal of the acetyl group. Histone deacetylases are related to other proteins. Pssm-ID: 425906 [Multi-domain] Cd Length: 298 Bit Score: 39.14 E-value: 3.60e-05
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| HDAC_classII_2 | cd11599 | Histone deacetylases and histone-like deacetylases, classII; This subfamily includes ... |
12-50 | 5.83e-04 | ||
Histone deacetylases and histone-like deacetylases, classII; This subfamily includes eukaryotic as well as bacterial Class II histone deacetylase (HDAC) and related proteins. Deacetylases of class II are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. In D. discoideum, where four homologs (HdaA, HdaB, HdaC, HdaD) have been identified, HDAC activity is important for regulating the timing of gene expression during development. Also, inhibition of HDAC activity by trichostatin A is shown to cause hyperacetylation of the histone and a delay in cell aggregation and differentiation. Pssm-ID: 212541 [Multi-domain] Cd Length: 288 Bit Score: 35.95 E-value: 5.83e-04
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| AcuC | COG0123 | Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites ... |
11-34 | 3.62e-03 | ||
Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites biosynthesis, transport and catabolism]; Pssm-ID: 439893 [Multi-domain] Cd Length: 308 Bit Score: 33.54 E-value: 3.62e-03
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