NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|238624099|ref|NP_001153780|]
View 

histone-lysine N-methyltransferase SETDB2 isoform b [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 210-706 1.45e-128

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


:

Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 381.49  E-value: 1.45e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 210 FSFNTYVQLARNYPKQKEVVSDVDISNGVesvpisfcneidsrklpqfkyrktvwpraynltnfssmFTDSCDCSEGCID 289
Cdd:cd10523    1 FSFNTYVQLDRNPQDQQQLVDDFDISNGA--------------------------------------FVDSCDCTDGCID 42

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 290 ITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCKCNRQLCQNRVVQHGPQVRLQVFKTEQKGWGV 369
Cdd:cd10523   43 ILKCACLQLTARAFSKSESSPSKGGRGYKYKRLQEPIPSGLYECNVSCKCNRMLCQNRVVQHGLQVRLQVFKTEKKGWGV 122

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 370 RCLDDIDRGTFVCIYSGRLLSRANTEKSYGIdengrdentmknifskkrklevacsdcevevlplglethprtaktekcp 449
Cdd:cd10523  123 RCLDDIDKGTFVCIYAGRVLSRARSPTEPLP------------------------------------------------- 153

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 450 pkfsnnpkeltvetkydnisriqyhsvirdpesktaifqhngkkmefvssesvtpedndgfkpprehlnsktkgaqkdss 529
Cdd:cd10523      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 530 sNHVDEFEDNlliesdviditkyreetpprsrcnqattldnqnikkaievqiqkpqegrstacqrqqvfcdeellSETKN 609
Cdd:cd10523  154 -PKLELPSEN-----------------------------------------------------------------EVEVV 167

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 610 TSSDSLTKFNK--GNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGYEAGT 687
Cdd:cd10523  168 TSWLILSKKRKlrENVCFLDASKEGNVGRFLNHSCCPNLFVQNVFVDTHDKNFPWVAFFTNRVVKAGTELTWDYSYDAGT 247

                        490
                 ....*....|....*....
gi 238624099 688 VPEKEIFCQCGVNKCRKKI 706
Cdd:cd10523  248 SPEQEIPCLCGVNKCQKKI 266
HMT_MBD cd01395
Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as ...
 152-212 6.99e-26

Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated transcriptional repression. SETDB1 and other proteins in this group have a similar domain architecture. SETDB1 is a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.


:

Pssm-ID: 238689  Cd Length: 60  Bit Score: 100.53  E-value: 6.99e-26
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238624099 152 PLQLPIKCHFQRRHAKTNSHSSALHVSYKTPCGRSLRNVEEVFRYLLETeCNFLFTDNFSF 212
Cdd:cd01395    1 PLHTPLLCGFQRMKYRARVGKVKKHVIYKAPCGRSLRNMSEVHRYLRET-CSFLTVDNFSF 60
 
Name Accession Description Interval E-value
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 210-706 1.45e-128

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 381.49  E-value: 1.45e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 210 FSFNTYVQLARNYPKQKEVVSDVDISNGVesvpisfcneidsrklpqfkyrktvwpraynltnfssmFTDSCDCSEGCID 289
Cdd:cd10523    1 FSFNTYVQLDRNPQDQQQLVDDFDISNGA--------------------------------------FVDSCDCTDGCID 42

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 290 ITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCKCNRQLCQNRVVQHGPQVRLQVFKTEQKGWGV 369
Cdd:cd10523   43 ILKCACLQLTARAFSKSESSPSKGGRGYKYKRLQEPIPSGLYECNVSCKCNRMLCQNRVVQHGLQVRLQVFKTEKKGWGV 122

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 370 RCLDDIDRGTFVCIYSGRLLSRANTEKSYGIdengrdentmknifskkrklevacsdcevevlplglethprtaktekcp 449
Cdd:cd10523  123 RCLDDIDKGTFVCIYAGRVLSRARSPTEPLP------------------------------------------------- 153

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 450 pkfsnnpkeltvetkydnisriqyhsvirdpesktaifqhngkkmefvssesvtpedndgfkpprehlnsktkgaqkdss 529
Cdd:cd10523      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 530 sNHVDEFEDNlliesdviditkyreetpprsrcnqattldnqnikkaievqiqkpqegrstacqrqqvfcdeellSETKN 609
Cdd:cd10523  154 -PKLELPSEN-----------------------------------------------------------------EVEVV 167

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 610 TSSDSLTKFNK--GNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGYEAGT 687
Cdd:cd10523  168 TSWLILSKKRKlrENVCFLDASKEGNVGRFLNHSCCPNLFVQNVFVDTHDKNFPWVAFFTNRVVKAGTELTWDYSYDAGT 247

                        490
                 ....*....|....*....
gi 238624099 688 VPEKEIFCQCGVNKCRKKI 706
Cdd:cd10523  248 SPEQEIPCLCGVNKCQKKI 266
HMT_MBD cd01395
Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as ...
 152-212 6.99e-26

Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated transcriptional repression. SETDB1 and other proteins in this group have a similar domain architecture. SETDB1 is a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.


Pssm-ID: 238689  Cd Length: 60  Bit Score: 100.53  E-value: 6.99e-26
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238624099 152 PLQLPIKCHFQRRHAKTNSHSSALHVSYKTPCGRSLRNVEEVFRYLLETeCNFLFTDNFSF 212
Cdd:cd01395    1 PLHTPLLCGFQRMKYRARVGKVKKHVIYKAPCGRSLRNMSEVHRYLRET-CSFLTVDNFSF 60
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 234-347 9.16e-19

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 81.70  E-value: 9.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099  234 ISNGVESVPISFCNEIDS-RKLPQFKYRKTVWPraynLTNFSSMFTDSCDCsEGCIDiTKCACLQLTarnaktsplsSDK 312
Cdd:pfam05033   1 ISKGKENVPIPVVNEVDDePPPPDFTYITSYIY----PKEFLLIIPQGCDC-GDCSS-EKCSCAQLN----------GGE 64

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 238624099  313 ITTGYKYKRLQR-QIPTGIYECSLLCKCNRQlCQNR 347
Cdd:pfam05033  65 FRFPYDKDGLLVpESKPPIYECNPLCGCPPS-CPNR 99
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 618-684 1.16e-14

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 70.83  E-value: 1.16e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 238624099   618 FNKGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYE 684
Cdd:smart00317  58 FDIDSDLCIDARRKGNLARFINHSCEPNCELLFVEVNGDDR----IVIFALRDIKPGEELTIDYGSD 120
MBD smart00391
Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, ...
 150-227 7.15e-12

Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, MeCP1) domain


Pssm-ID: 128673  Cd Length: 77  Bit Score: 61.62  E-value: 7.15e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099   150 ENPLQLPIKCHFQRRHA--KTNSHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSFNTYVqlaRNYPKQKE 227
Cdd:smart00391   1 GDPLRLPLPCGWRRETKqrKSGRSAGKFDVYYISPCGKKLRSKSELARYLHKNGDLSLDLECFDFNATV---PVGPKFTP 77
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
626-705 1.52e-10

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 59.59  E-value: 1.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 626 LDATKEGNVGRFLNHSCCPNLlvqnVFVETHNRNFplvaFFTNRYVKARTELTWDYGYEagtVPEKEIFCQCGvnKCRKK 705
Cdd:COG2940   68 IDGALGGNPARFINHSCDPNC----EADEEDGRIF----IVALRDIAAGEELTYDYGLD---YDEEEYPCRCP--NCRGT 134
MBD pfam01429
Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one ...
 149-216 2.06e-08

Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase.


Pssm-ID: 396147 [Multi-domain]  Cd Length: 76  Bit Score: 51.59  E-value: 2.06e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099  149 GENPLQLPIKCHFQR--RHAKTNSHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSFNTYV 216
Cdd:pfam01429   3 RKREDRLPLPPGWRReeRQRKSGSKAGKVDVFYYSPTGKKLRSKSEVARYLEANGGTSPKLEDFSFTVRS 72
 
Name Accession Description Interval E-value
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 210-706 1.45e-128

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 381.49  E-value: 1.45e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 210 FSFNTYVQLARNYPKQKEVVSDVDISNGVesvpisfcneidsrklpqfkyrktvwpraynltnfssmFTDSCDCSEGCID 289
Cdd:cd10523    1 FSFNTYVQLDRNPQDQQQLVDDFDISNGA--------------------------------------FVDSCDCTDGCID 42

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 290 ITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCKCNRQLCQNRVVQHGPQVRLQVFKTEQKGWGV 369
Cdd:cd10523   43 ILKCACLQLTARAFSKSESSPSKGGRGYKYKRLQEPIPSGLYECNVSCKCNRMLCQNRVVQHGLQVRLQVFKTEKKGWGV 122

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 370 RCLDDIDRGTFVCIYSGRLLSRANTEKSYGIdengrdentmknifskkrklevacsdcevevlplglethprtaktekcp 449
Cdd:cd10523  123 RCLDDIDKGTFVCIYAGRVLSRARSPTEPLP------------------------------------------------- 153

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 450 pkfsnnpkeltvetkydnisriqyhsvirdpesktaifqhngkkmefvssesvtpedndgfkpprehlnsktkgaqkdss 529
Cdd:cd10523      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 530 sNHVDEFEDNlliesdviditkyreetpprsrcnqattldnqnikkaievqiqkpqegrstacqrqqvfcdeellSETKN 609
Cdd:cd10523  154 -PKLELPSEN-----------------------------------------------------------------EVEVV 167

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 610 TSSDSLTKFNK--GNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGYEAGT 687
Cdd:cd10523  168 TSWLILSKKRKlrENVCFLDASKEGNVGRFLNHSCCPNLFVQNVFVDTHDKNFPWVAFFTNRVVKAGTELTWDYSYDAGT 247

                        490
                 ....*....|....*....
gi 238624099 688 VPEKEIFCQCGVNKCRKKI 706
Cdd:cd10523  248 SPEQEIPCLCGVNKCQKKI 266
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 277-706 7.52e-87

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 272.50  E-value: 7.52e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 277 FTDSCDCSEGCIDITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCKCNRQLCQNRVVQHGPQVR 356
Cdd:cd10541   14 FLVGCDCTDGCRDKSKCACHQLTIQATACTPGGQDNPTAGYQYKRLEECLPTGVYECNKLCKCDPNMCQNRLVQHGLQVR 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 357 LQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSYGIDengrdentMKNIFSKKRKLEVACSdcevevlplgl 436
Cdd:cd10541   94 LQLFKTQNKGWGIRCLDDIAKGTFVCIYAGKILTDDFADKEGLEM--------GDEYFANLDHIEESCY----------- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 437 ethprtaktekcppkfsnnpkeLTVETKYDNISRIQYHsvirdpesktaifqhngkkmefvsseSVTPedndgfkppreh 516
Cdd:cd10541  155 ----------------------IIDAKLEGNLGRYLNH--------------------------SCSP------------ 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 517 lnsktkgaqkdsssnhvdefedNLLIEsdviditkyreetpprsrcnqattldnqnikkaievqiqkpqegrstacqrqq 596
Cdd:cd10541  175 ----------------------NLFVQ----------------------------------------------------- 179

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 597 vfcdeellsetkntssdsltkfnkgNVFlldatkegnvgrflnhsccpnllvqnvfVETHNRNFPLVAFFTNRYVKARTE 676
Cdd:cd10541  180 -------------------------NVF----------------------------VDTHDLRFPWVAFFASKRIKAGTE 206

                        410       420       430
                 ....*....|....*....|....*....|
gi 238624099 677 LTWDYGYEAGTVPEKEIFCQCGVNKCRKKI 706
Cdd:cd10541  207 LTWDYNYEVGSVEGKELLCCCGSNECRGRL 236
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 233-707 2.17e-83

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 265.31  E-value: 2.17e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 233 DISNGVESVPISFCNEIDSRKLPQFKYRKTVWPRAYNLTNFSSMFTDSCDCSEGCIDITKCACLQLTARNAKTSPLSSDK 312
Cdd:cd10517    8 DISYGKEGVPIPCVNEIDNSSPPYVEYSKERIPGKGVNINLDPDFLVGCDCTDGCRDKSKCACQQLTIEATAATPGGQIN 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 313 ITTGYKYKRLQRQIPTGIYECSLLCKCNRQlCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSra 392
Cdd:cd10517   88 PSAGYQYRRLMEKLPTGVYECNSRCKCDKR-CYNRVVQNGLQVRLQVFKTEKKGWGIRCLDDIPKGSFVCIYAGQILT-- 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 393 nteksygidengrdentmknifskkrklevacsdcevevlplglethprtaktekcppkfsnnpkeltvetkydnisriq 472
Cdd:cd10517      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 473 yhsvirdpesktaifqhngkkmefvssesvtpedndgfkpprehlnskTKGAQKDsSSNHVDEFEDNL-LIESdviditk 551
Cdd:cd10517  165 ------------------------------------------------EDEANEE-GLQYGDEYFAELdYIEV------- 188

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 552 yreetpprsrcnqattldnqnikkaievqIQKPQEGrstacqrqqvfcdeellsetKNTSSDSltkfnkgNVFLLDATKE 631
Cdd:cd10517  189 -----------------------------VEKLKEG--------------------YESDVEE-------HCYIIDAKSE 212

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 238624099 632 GNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGYEAGTVPEKEIFCQCGVNKCRKKIL 707
Cdd:cd10517  213 GNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASRYIRAGTELTWDYNYEVGSVPGKVLYCYCGSSNCRGRLL 288
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 256-682 1.75e-34

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 130.95  E-value: 1.75e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 256 QFKYRKTVWPRAYNLTNFSsmFTDSCDCSEGCIDiTKCACLQLTARNaktsplssdkitTGYKYKRLQR--QIPTGIYEC 333
Cdd:cd10538    4 TYIKDNIVGKNVQPFSNII--DSVGCKCKDDCLD-SKCACAAESDGI------------FAYTKNGLLRlnNSPPPIFEC 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 334 SLLCKCNRQlCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRllsranteksygidengrdentmkni 413
Cdd:cd10538   69 NSKCSCDDD-CKNRVVQRGLQARLQVFRTSKKGWGVRSLEFIPKGSFVCEYVGE-------------------------- 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 414 fskkrklevacsdcevevlplglethprtaktekcppkfsnnpkeltvetkydnisriqyhsVIRDPESKTaifqhngkk 493
Cdd:cd10538  122 --------------------------------------------------------------VITTSEADR--------- 130

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 494 mefvssesvtpedndgfkppREHLNSKtkgaQKDSSSNHVDEFEDNLLIEsdviditkyreetpprsrcnqattldnqni 573
Cdd:cd10538  131 --------------------RGKIYDK----SGGSYLFDLDEFSDSDGDG------------------------------ 156

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 574 kkaievqiqkpqegrstacqrqQVFCdeellsetkntssdsltkfnkgnvflLDATKEGNVGRFLNHSCCPNLLVQNVFV 653
Cdd:cd10538  157 ----------------------EELC--------------------------VDATFCGNVSRFINHSCDPNLFPFNVVI 188

                        410       420
                 ....*....|....*....|....*....
gi 238624099 654 ETHNRNFPLVAFFTNRYVKARTELTWDYG 682
Cdd:cd10538  189 DHDDLRYPRIALFATRDILPGEELTFDYG 217
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 280-683 8.94e-31

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 120.59  E-value: 8.94e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 280 SCDCSEGCIDITK-CAClqlTARNAKTSPLSsdkittgyKYKRLQRQIPTgIYECSLLCKCNRQlCQNRVVQHGPQVRLQ 358
Cdd:cd10545   23 GCDCKNRCTDGASdCAC---VKKNGGEIPYN--------FNGRLIRAKPA-IYECGPLCKCPPS-CYNRVTQKGLRYRLE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 359 VFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANteksygIDENGRDENTMKNIfskkrklevacsDCevevlplglet 438
Cdd:cd10545   90 VFKTAERGWGVRSWDSIPAGSFICEYVGELLDTSE------ADTRSGNDDYLFDI------------DN----------- 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 439 hprtaktekcppkfsnnpkeltvetKYDNisriqyhsvirdpesktaifqhngkKMEFVSSESVTPEDNDGFKPPREHLN 518
Cdd:cd10545  141 -------------------------RQTN-------------------------RGWDGGQRLDVGMSDGERSSAEDEES 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 519 SKtkgaqkdsssnhvdefednlliesdviditkyreetpprsrcnqattldnqnikkaievqiqkpqegrstacqrqqvf 598
Cdd:cd10545  171 SE------------------------------------------------------------------------------ 172

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 599 cdeellsetkntssdsltkfnkgnvFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELT 678
Cdd:cd10545  173 -------------------------FTIDAGSFGNVARFINHSCSPNLFVQCVLYDHNDLRLPRVMLFAADNIPPLQELT 227


                 ....*
gi 238624099 679 WDYGY 683
Cdd:cd10545  228 YDYGY 232
HMT_MBD cd01395
Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as ...
 152-212 6.99e-26

Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated transcriptional repression. SETDB1 and other proteins in this group have a similar domain architecture. SETDB1 is a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.


Pssm-ID: 238689  Cd Length: 60  Bit Score: 100.53  E-value: 6.99e-26
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238624099 152 PLQLPIKCHFQRRHAKTNSHSSALHVSYKTPCGRSLRNVEEVFRYLLETeCNFLFTDNFSF 212
Cdd:cd01395    1 PLHTPLLCGFQRMKYRARVGKVKKHVIYKAPCGRSLRNMSEVHRYLRET-CSFLTVDNFSF 60
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 281-405 2.08e-24

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 102.76  E-value: 2.08e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 281 CDCSEGCIDITKCACLQLtarnaktsplsSDKITTGYKYKRLQRQIPTGIYECSLLCKCNrQLCQNRVVQHGPQVRLQVF 360
Cdd:cd10542   25 CECTEDCHNNNPTCCPAE-----------SGVKFAYDKQGRLRLPPGTPIYECNSRCKCG-PDCPNRVVQRGRKVPLCIF 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 238624099 361 KTEQ-KGWGVRCLDDIDRGTFVCIYSGRLLSRANTE---KSYgiDENGR 405
Cdd:cd10542   93 RTSNgRGWGVKTLEDIKKGTFVMEYVGEIITSEEAErrgKIY--DANGR 139
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 255-390 3.22e-24

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 102.38  E-value: 3.22e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 255 PQFKYRKTVWPRAYNLTNFSSMFTDSCDCSEGCIDITKCACLQLTARNAKTSPLSSDKITtgyKYKRLqrqiptgIYECS 334
Cdd:cd10544    1 PDFQYTPENVPGPGADTDPNEITFPGCDCKTSSCEPETCSCLRKYGPNYDDDGCLLDFDG---KYSGP-------VFECN 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 238624099 335 LLCKCNRQlCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLS 390
Cdd:cd10544   71 SMCKCSES-CQNRVVQNGLQFKLQVFKTPKKGWGLRTLEFIPKGRFVCEYAGEVIG 125
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 280-390 5.62e-23

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 98.18  E-value: 5.62e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 280 SCDCSEGCiDITKCACLQLTARNA--KTSPLSSDkittgykykrLQRQIPTGIYECSLLCKCNRQlCQNRVVQHGPQVRL 357
Cdd:cd10543   26 TCSCRDDC-SSDNCVCGRLSVRCWydKEGRLLPD----------FNKLDPPLIFECNRACSCWRN-CRNRVVQNGIRYRL 93

                         90       100       110
                 ....*....|....*....|....*....|...
gi 238624099 358 QVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLS 390
Cdd:cd10543   94 QLFRTRGMGWGVRALQDIPKGTFVCEYIGELIS 126
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 615-704 1.58e-19

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 88.50  E-value: 1.58e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 615 LTKFNKGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDY------GYEAGTV 688
Cdd:cd10542  145 LDYNDDDCEYTVDAAYYGNISHFINHSCDPNLAVYAVWINHLDPRLPRIAFFAKRDIKAGEELTFDYlmtgtgGSSESTI 224

                         90
                 ....*....|....*....
gi 238624099 689 PEKE---IFCQCGVNKCRK 704
Cdd:cd10542  225 PKPKdvrVPCLCGSKNCRK 243
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 281-406 4.21e-19

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 86.91  E-value: 4.21e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 281 CDCSEGCIDiTKCACLQLTAR-----NAKTSPlssdkittgyKYKRLQrqiPTGIYECSLLCKCNRQlCQNRVVQHGPQV 355
Cdd:cd10535   27 CVCIDDCSS-SNCMCGQLSMRcwydkDGRLLP----------EFNMAE---PPLIFECNHACSCWRN-CRNRVVQNGLRA 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 238624099 356 RLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANT----EKSYGIDENGRD 406
Cdd:cd10535   92 RLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEAdvreEDSYLFDLDNKD 146
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 234-347 9.16e-19

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 81.70  E-value: 9.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099  234 ISNGVESVPISFCNEIDS-RKLPQFKYRKTVWPraynLTNFSSMFTDSCDCsEGCIDiTKCACLQLTarnaktsplsSDK 312
Cdd:pfam05033   1 ISKGKENVPIPVVNEVDDePPPPDFTYITSYIY----PKEFLLIIPQGCDC-GDCSS-EKCSCAQLN----------GGE 64

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 238624099  313 ITTGYKYKRLQR-QIPTGIYECSLLCKCNRQlCQNR 347
Cdd:pfam05033  65 FRFPYDKDGLLVpESKPPIYECNPLCGCPPS-CPNR 99
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 281-406 1.41e-18

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 85.45  E-value: 1.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 281 CDCSEGCIDiTKCACLQLTARnaktspLSSDKitTGYKYKRLQRQIPTGIYECSLLCKCNRQlCQNRVVQHGPQVRLQVF 360
Cdd:cd10533   27 CTCVDDCSS-SNCLCGQLSIR------CWYDK--DGRLLQEFNKIEPPLIFECNQACSCWRN-CKNRVVQSGIKVRLQLY 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 238624099 361 KTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANT----EKSYGIDENGRD 406
Cdd:cd10533   97 RTAKMGWGVRALQTIPQGTFICEYVGELISDAEAdvreDDSYLFDLDNKD 146
MBD cd00122
MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of ...
 152-212 5.67e-18

MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding protein which binds specifically to methylated DNA. The MBD can recognize a single symmetrically methylated CpG either as naked DNA or within chromatin. MeCP2, MBD1 and MBD2 (and likely MBD3) form complexes with histone deacetylase and are involved in histone deacetylase-dependent repression of transcription. MBD4 is an endonuclease that forms a complex with the DNA mismatch-repair protein MLH1. The MBDs present in putative chromatin remodelling subunit, BAZ2A, and putative histone methyltransferase, CLLD8, represent two phylogenetically distinct groups within the MBD protein family.


Pssm-ID: 238069  Cd Length: 62  Bit Score: 78.13  E-value: 5.67e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 238624099 152 PLQLPIKCHFQRRHAKTNSHS-SALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSF 212
Cdd:cd00122    1 PLRDPLPPGWKRELVIRKSGSaGKGDVYYYSPCGKKLRSKPEVARYLEKTGPSSLDLENFSF 62
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 621-703 5.70e-18

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 83.54  E-value: 5.70e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 621 GNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGYEAGTVPEKEIFCQCGVN 700
Cdd:cd10543  147 GETYCIDARRYGNISRFINHLCEPNLIPVRVFVEHQDLRFPRIAFFASRDIKAGEELGFDYGEKFWRIKGKYFTCRCGSP 226


                 ...
gi 238624099 701 KCR 703
Cdd:cd10543  227 KCK 229
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 249-403 8.73e-18

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 83.78  E-value: 8.73e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 249 IDSRKLPQFKYRKTVWPRaynltnfSSMFTDSCDCS--EGCI--DITKCACLQltarnaktsplSSDKITTGY-KYKRLQ 323
Cdd:cd20073    1 IDFEFITSYRYGLGIEPP-------DPLFISGCSCSklGGCDlnNPGSCQCLE-----------DSNEKSFAYdEYGRVR 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 324 RQIPTGIYECSLLCKCNRQlCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSYGIDEN 403
Cdd:cd20073   63 ANTGSIIYECNENCDCGIN-CPNRVVQRGRKLPLEIFKTKHKGWGLRCPRFIKAGTFIGVYLGEVITQSEAEIRGKKYDN 141
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 275-397 2.31e-16

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 79.67  E-value: 2.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 275 SMFTDSCDCSEG--CIDITkCACLQLTARnaKTSPLSSDKI----TTGYKYKRLQRQIPTG---IYECSLLCKCNrQLCQ 345
Cdd:cd19473   20 EEFRSGCECTDDedCMYSG-CLCLQDVDP--DDDRDPGKKKnayhSSGAKKGCLRGHMLNSrlpIYECHEGCACS-DDCP 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 346 NRVVQHGPQVRLQVFKTEQ-KGWGVRCLDDIDRGTFVCIYSGRLLS-------RANTEKS 397
Cdd:cd19473   96 NRVVERGRKVPLQIFRTSDgRGWGVRSTVDIKRGQFVDCYVGEIITpeeaqrrRDAATIA 155
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 555-703 3.53e-16

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 78.52  E-value: 3.53e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 555 ETPPRSRCNQAT----TLDNQNIKKAIEVQIQKPQEG------RSTACQRQQVFCDE---ELLSETK-NTSSDSLTKFN- 619
Cdd:cd10533   63 EPPLIFECNQACscwrNCKNRVVQSGIKVRLQLYRTAkmgwgvRALQTIPQGTFICEyvgELISDAEaDVREDDSYLFDl 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 620 ---KGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGYEAGTVPEKEIFCQ 696
Cdd:cd10533  143 dnkDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQ 222


                 ....*..
gi 238624099 697 CGVNKCR 703
Cdd:cd10533  223 CGSEKCK 229
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 626-706 1.04e-14

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 71.46  E-value: 1.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 626 LDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYEA-GTVPEKeifCQCGVNKCRK 704
Cdd:cd19172   67 IDATKKGNLSRFINHSCEPNCETQKWTVNGELR----VGFFAKRDIPAGEELTFDYQFERyGKEAQK---CYCGSPNCRG 139


                 ..
gi 238624099 705 KI 706
Cdd:cd19172  140 YI 141
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 618-684 1.16e-14

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 70.83  E-value: 1.16e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 238624099   618 FNKGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYE 684
Cdd:smart00317  58 FDIDSDLCIDARRKGNLARFINHSCEPNCELLFVEVNGDDR----IVIFALRDIKPGEELTIDYGSD 120
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 622-704 3.15e-14

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 73.00  E-value: 3.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 622 NVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDY-------------------- 681
Cdd:cd10525  149 DVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIALFATRTIRAGEELTFDYnmqvdpvdaestkmdsnfgl 228

                         90       100
                 ....*....|....*....|....
gi 238624099 682 -GYEAGTVPEKEIFCQCGVNKCRK 704
Cdd:cd10525  229 aGLPGSPKKRVRIECKCGVRSCRK 252
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 617-703 8.42e-14

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 68.82  E-value: 8.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 617 KFNKGNVflLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYEagTVPEKEIFCQ 696
Cdd:cd10531   58 SLSDDVV--IDATRKGNLSRFINHSCEPNCETQKWIVNGEYR----IGIFALRDIPAGEELTFDYNFV--NYNEAKQVCL 129


                 ....*..
gi 238624099 697 CGVNKCR 703
Cdd:cd10531  130 CGAQNCR 136
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 624-703 8.99e-14

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 71.46  E-value: 8.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 624 FLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDY---GY------EAGTVPEKE-- 692
Cdd:cd10532  149 FTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTIKAGEELTFDYqmkGSgdlssdSIDNSPAKKrv 228

                         90
                 ....*....|..
gi 238624099 693 -IFCQCGVNKCR 703
Cdd:cd10532  229 rTVCKCGAVTCR 240
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 624-706 9.11e-14

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 68.86  E-value: 9.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 624 FLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYEAGTVPEKEIfCQCGVNKCR 703
Cdd:cd19174   62 MVIDGYRMGNEARFVNHSCDPNCEMQKWSVNGVYR----IGLFALKDIPAGEELTYDYNFHSFNVEKQQP-CKCGSPNCR 136


                 ...
gi 238624099 704 KKI 706
Cdd:cd19174  137 GVI 139
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 627-703 7.64e-13

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 66.47  E-value: 7.64e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 238624099 627 DATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYEAgtVPEKEIFCQCGVNKCR 703
Cdd:cd10518   80 DATKKGNIARFINHSCDPNCYAKIITVDGEKH----IVIFAKRDIAPGEELTYDYKFPI--EDEEKIPCLCGAPNCR 150
MBD smart00391
Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, ...
 150-227 7.15e-12

Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, MeCP1) domain


Pssm-ID: 128673  Cd Length: 77  Bit Score: 61.62  E-value: 7.15e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099   150 ENPLQLPIKCHFQRRHA--KTNSHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSFNTYVqlaRNYPKQKE 227
Cdd:smart00391   1 GDPLRLPLPCGWRRETKqrKSGRSAGKFDVYYISPCGKKLRSKSELARYLHKNGDLSLDLECFDFNATV---PVGPKFTP 77
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 626-704 8.33e-12

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 63.56  E-value: 8.33e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 238624099 626 LDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYeagTVPEKEIFCQCGVNKCRK 704
Cdd:cd19170   78 VDATMHGNAARFINHSCEPNCYSRVVNIDGKKH----IVIFALRRILRGEELTYDYKF---PIEDVKIPCTCGSKKCRK 149
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 615-682 4.02e-11

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 60.61  E-value: 4.02e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099  615 LTKFNKGNVFLLDAT--KEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYG 682
Cdd:pfam00856  50 LFTLDEDSEYCIDARalYYGNWARFINHSCDPNCEVRVVYVNGGPR----IVIFALRDIKPGEELTIDYG 115
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 320-396 7.97e-11

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 62.99  E-value: 7.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 320 KRLQRQIPTG--IYECSLLCKCNRQlCQNRVVQHGPQVRLQVFKTEQ-KGWGVRCLDDIDRGTFVCIYSGRLLSRANTEK 396
Cdd:cd10532   48 EHGQLKIPPGtpIYECNSRCKCGPD-CPNRVVQKGTQYSLCIFRTSNgRGWGVKTLQKIKKNSFVMEYVGEVITSEEAER 126
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 594-703 8.51e-11

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 60.52  E-value: 8.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 594 RQQVFCDEELLSETKNTSSDSLTKFNKGNVflLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKA 673
Cdd:cd20072   48 RQQVADEREKRYLRQGIGSSYLFRIDDDTV--VDATKKGNIARFINHCCDPNCTAKIIKVEGEKR----IVIYAKRDIAA 121

                         90       100       110
                 ....*....|....*....|....*....|
gi 238624099 674 RTELTWDYGYEagtVPEKEIFCQCGVNKCR 703
Cdd:cd20072  122 GEELTYDYKFP---REEDKIPCLCGAPNCR 148
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 624-703 1.27e-10

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 60.04  E-value: 1.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 624 FLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYeagTVPEKEIFCQCGVNKCR 703
Cdd:cd19169   76 TIIDATKCGNLARFINHSCNPNCYAKIITVESQKK----IVIYSKRPIAVNEEITYDYKF---PIEDEKIPCLCGAPQCR 148
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 634-682 1.27e-10

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 57.65  E-value: 1.27e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 238624099 634 VGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYG 682
Cdd:cd08161   28 LARFINHSCEPNCEFEEVYVGGKPR----VFIVALRDIKAGEELTVDYG 72
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
626-705 1.52e-10

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 59.59  E-value: 1.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 626 LDATKEGNVGRFLNHSCCPNLlvqnVFVETHNRNFplvaFFTNRYVKARTELTWDYGYEagtVPEKEIFCQCGvnKCRKK 705
Cdd:COG2940   68 IDGALGGNPARFINHSCDPNC----EADEEDGRIF----IVALRDIAAGEELTYDYGLD---YDEEEYPCRCP--NCRGT 134
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 618-704 4.58e-10

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 58.60  E-value: 4.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 618 FNKGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYEAGTvPEKEIFCQC 697
Cdd:cd19171   70 FRIDNDWVIDATMTGGPARYINHSCNPNCVAEVVTFDKEKK----IIIISNRRIAKGEELTYDYKFDFED-DQHKIPCLC 144


                 ....*..
gi 238624099 698 GVNKCRK 704
Cdd:cd19171  145 GAPNCRK 151
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 330-396 5.94e-10

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 60.29  E-value: 5.94e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 238624099 330 IYECSLLCKCNRQlCQNRVVQHGPQVRLQVFKTEQ-KGWGVRCLDDIDRGTFVCIYSGRLLSRANTEK 396
Cdd:cd10525   62 IYECNSRCRCGPD-CPNRVVQKGIQYDLCIFRTDNgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAER 128
PreSET smart00468
N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal ...
 233-338 7.72e-10

N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal to some SET domains. Function is unknown. Unpublished.


Pssm-ID: 128744 [Multi-domain]  Cd Length: 98  Bit Score: 56.27  E-value: 7.72e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099   233 DISNGVESVPISFCNEIDSRKLP-QFKYRKTVWPRAYNLTNFSSMFTDSCDCSEGCIDITKCACLQLTARNAKTSplssd 311
Cdd:smart00468   3 DISNGKENVPVPLVNEVDEDPPPpDFEYISEYIYGQGVPIDRSPSPLVGCSCSGDCSSSNKCECARKNGGEFAYE----- 77

                           90       100
                   ....*....|....*....|....*..
gi 238624099   312 kittgyKYKRLQRQIPTGIYECSLLCK 338
Cdd:smart00468  78 ------LNGGLRLKRKPLIYECNSRCS 98
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 624-706 8.49e-10

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 57.43  E-value: 8.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 624 FLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYEA-GTvpekEIFCQCGVNKC 702
Cdd:cd19175   63 MVIDATFKGNLSRFINHSCDPNCELQKWQVDGETR----IGVFAIRDIKKGEELTYDYQFVQfGA----DQDCHCGSKNC 134


                 ....
gi 238624099 703 RKKI 706
Cdd:cd19175  135 RGKL 138
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 618-683 1.25e-09

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 56.48  E-value: 1.25e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 238624099 618 FNKGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGY 683
Cdd:cd10519   56 FNLNDQFVVDATRKGNKIRFANHSSNPNCYAKVMMVNGDHR----IGIFAKRDIEAGEELFFDYGY 117
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 625-703 3.95e-09

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 55.80  E-value: 3.95e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 238624099 625 LLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYeagTVPEKEIFCQCGVNKCR 703
Cdd:cd19204   78 IIDATKCGNLARFINHCCTPNCYAKVITIESQKK----IVIYSKQPIGVNEEITYDYKF---PIEDNKIPCLCGTENCR 149
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 625-704 7.18e-09

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 55.41  E-value: 7.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 625 LLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYEAGTvPEKEIFCQCGVNKCRK 704
Cdd:cd19206   77 VVDATMHGNAARFINHSCEPNCYSRVINIDGQKH----IVIFAMRKIYRGEELTYDYKFPIED-ASNKLPCNCGAKKCRK 151
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 594-704 1.40e-08

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 54.25  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 594 RQQVFCDEELLSETKNTSsdsLTKFNKGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKA 673
Cdd:cd19208   50 RNEVANRKEKLYESQNRG---VYMFRIDNDHVIDATLTGGPARYINHSCAPNCVAEVVTFEKGHK----IIISSSRRIQK 122

                         90       100       110
                 ....*....|....*....|....*....|.
gi 238624099 674 RTELTWDYGYEAGTvPEKEIFCQCGVNKCRK 704
Cdd:cd19208  123 GEELCYDYKFDFED-DQHKIPCHCGAVNCRK 152
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 625-703 1.88e-08

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 53.91  E-value: 1.88e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 238624099 625 LLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYeagTVPEKEIFCQCGVNKCR 703
Cdd:cd19205   78 IIDATKCGNFARFINHSCNPNCYAKVITVESQKK----IVIYSKQHINVNEEITYDYKF---PIEDVKIPCLCGSENCR 149
MBD pfam01429
Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one ...
 149-216 2.06e-08

Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase.


Pssm-ID: 396147 [Multi-domain]  Cd Length: 76  Bit Score: 51.59  E-value: 2.06e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099  149 GENPLQLPIKCHFQR--RHAKTNSHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSFNTYV 216
Cdd:pfam01429   3 RKREDRLPLPPGWRReeRQRKSGSKAGKVDVFYYSPTGKKLRSKSEVARYLEANGGTSPKLEDFSFTVRS 72
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 355-416 2.17e-08

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 53.11  E-value: 2.17e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 238624099   355 VRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSYGI-DENGRDENTMKNIFSK 416
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAyDTDGAKAFYLFDIDSD 63
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 624-702 4.50e-08

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 52.70  E-value: 4.50e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 238624099 624 FLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYEAGTVPEKEifCQCGVNKC 702
Cdd:cd19173   65 RIIDAGPKGNLSRFMNHSCQPNCETQKWTVNGDTR----VGLFAVRDIPAGEELTFNYNLDCLGNEKKV--CRCGAPNC 137
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 600-702 6.65e-08

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 52.30  E-value: 6.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 600 DEELLSETKNTSSDSLTKF-----NKGNVflLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKAR 674
Cdd:cd19211   38 EEECMARIKHAHENDITHFymltiDKDRI--IDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTR----VGLFAVCDIPAG 111

                         90       100
                 ....*....|....*....|....*...
gi 238624099 675 TELTWDYGYEAgtVPEKEIFCQCGVNKC 702
Cdd:cd19211  112 TELTFNYNLDC--LGNEKTVCRCGAPNC 137
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 625-704 9.18e-08

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 51.95  E-value: 9.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 625 LLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYEAGTVPEKeIFCQCGVNKCRK 704
Cdd:cd19207   77 VVDATMHGNAARFINHSCEPNCYSRVIHVEGQKH----IVIFALRKIYRGEELTYDYKFPIEDASNK-LPCNCGAKRCRR 151
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 594-704 1.16e-07

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 51.62  E-value: 1.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 594 RQQVFCDEELLSETKNTSsdsLTKFNKGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKA 673
Cdd:cd19209   51 RNEVANRREKIYEEQNRG---IYMFRINNEHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDK----IIIISSRRIPK 123

                         90       100       110
                 ....*....|....*....|....*....|.
gi 238624099 674 RTELTWDYGYEAGTvPEKEIFCQCGVNKCRK 704
Cdd:cd19209  124 GEELTYDYQFDFED-DQHKIPCHCGAWNCRK 153
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 618-683 3.37e-07

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 49.53  E-value: 3.37e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 238624099 618 FNKGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGY 683
Cdd:cd19218   59 FNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHR----IGIFAKRAIQTGEELFFDYRY 120
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 619-684 3.39e-07

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 49.65  E-value: 3.39e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 238624099 619 NKGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYE 684
Cdd:cd10522   58 LNGDILVIDAGKKGNLTRFINHSDQPNLELIVRTLKGEQH----IGFVAIRDIKPGEELFISYGPK 119
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 625-702 4.53e-07

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 49.54  E-value: 4.53e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 238624099 625 LLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGYEAgtVPEKEIFCQCGVNKC 702
Cdd:cd19210   66 IIDAGPKGNYARFMNHCCQPNCETQKWTVNGDTR----VGLFALCDIKAGTELTFNYNLEC--LGNGKTVCKCGAPNC 137
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 618-683 5.05e-07

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 49.29  E-value: 5.05e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 238624099 618 FNKGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTELTWDYGY 683
Cdd:cd19217   61 FNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHR----IGIFAKRAIQQGEELFFDYRY 122
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 357-398 1.02e-06

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 48.83  E-value: 1.02e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 238624099 357 LQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLS----RANTEKSY 398
Cdd:cd19174    2 LERFRTEDKGWGVRTKEPIKAGQFIIEYVGEVVSeqefRRRMIEQY 47
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 620-682 1.28e-06

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 48.34  E-value: 1.28e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 238624099 620 KGNVFLLDATKE-GNVGRFLNHSCC-PNLLVQNVFVETHnrnfPLVAFFTNRYVKARTELTWDYG 682
Cdd:cd10528   79 KGKTYCVDATKEsGRLGRLINHSKKkPNLKTKLLVIDGV----PHLILVAKRDIKPGEELLYDYG 139
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 600-702 1.27e-05

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 45.69  E-value: 1.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 600 DEELLSETKNTSSDSLTKFNKGNVF---LLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRnfplVAFFTNRYVKARTE 676
Cdd:cd19212   38 EEECRLRIKRAHENSVTNFYMLTVTkdrIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVR----VGLFALCDIPAGME 113

                         90       100
                 ....*....|....*....|....*.
gi 238624099 677 LTWDYGYEAgtVPEKEIFCQCGVNKC 702
Cdd:cd19212  114 LTFNYNLDC--LGNGRTECHCGADNC 137
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 357-390 1.45e-05

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 45.32  E-value: 1.45e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 238624099 357 LQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLS 390
Cdd:cd10531    2 LELFRTEKKGWGVKAKEDIQKGEFIIEYVGEVID 35
HAT_MBD cd01397
Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as ...
 153-214 8.23e-05

Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The Drosophila melanogaster toutatis protein, a putative subunit of the chromatin-remodeling complex, and other such proteins in this group share a similar domain architecture with BAZ2A, as does the Caenorhabditis elegans flectin homolog.


Pssm-ID: 238691 [Multi-domain]  Cd Length: 73  Bit Score: 41.24  E-value: 8.23e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 238624099 153 LQLPIKcHFQRRHAKTNSHSSALH--VSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSFNT 214
Cdd:cd01397    2 LRVPLE-LGWRRETRIRGLGGRIQgeVAYYAPCGKKLRQYPEVIKYLSKNGISLLSRENFSFSA 64
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 356-390 1.24e-04

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 42.57  E-value: 1.24e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 238624099 356 RLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLS 390
Cdd:cd19172    3 KVEVFRTEKKGWGLRAAEDLPKGTFVIEYVGEVLD 37
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 353-389 4.48e-04

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 41.07  E-value: 4.48e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 238624099 353 PQVrlQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLL 389
Cdd:cd19210    2 PEV--EIFRTLGRGWGLRCKTDIKKGEFVNEYVGELI 36
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 347-449 5.19e-04

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 40.64  E-value: 5.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 347 RVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANT---EKSYgidenGRDENTMKNIFSKKRKLEVA 423
Cdd:cd10528    9 ELILSGKEEGLKVIEIDGKGRGVIATRPFEKGDFVVEYHGDLITITEAkkrEALY-----AKDPSTGCYMYYFQYKGKTY 83

                         90       100       110
                 ....*....|....*....|....*....|
gi 238624099 424 CSDCEVEVLPLG-LETHPRTA---KTEKCP 449
Cdd:cd10528   84 CVDATKESGRLGrLINHSKKKpnlKTKLLV 113
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 355-392 8.59e-04

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 40.38  E-value: 8.59e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 238624099 355 VRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRA 392
Cdd:cd19173    2 PPTEPFKTGDRGWGLRTKRDIKKGDFVIEYVGELIDEE 39
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 366-426 8.74e-04

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 39.43  E-value: 8.74e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 238624099  366 GWGVRCLDDIDRGTFVCIYSGR-LLSRANTEKSYGIDENGRDENTMKNIFSKKRKLEVACSD 426
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLELRLWGPYLFTLDEDSEYCID 62
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 626-683 1.99e-03

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 38.79  E-value: 1.99e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 626 LDATKEGNVGRFLNHSCCPNLLVQNVFVEthnRNFPLVAFFTNRYVKARTELT--WDYGY 683
Cdd:cd10529   71 VDARKYGNEARFIRRSCRPNAELRHVVVS---NGELRLFIFALKDIRKGTEITipFDYDY 127
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 600-682 4.46e-03

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 37.94  E-value: 4.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 600 DEELLSETKNTSSDSLTKFNKGNVFLLDATKEGNVGRFLNH----SCCPNLLVQNVFVETHNRnfplVAFFTNRYVKART 675
Cdd:cd19168   39 DEGVRREHRRGDVSYLYLFEEQEGIWVDAAIYGNLSRYINHatdkVKTGNCMPKIMYVNHEWR----IKFTAIKDIKIGE 114


                 ....*..
gi 238624099 676 ELTWDYG 682
Cdd:cd19168  115 ELFFNYG 121
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 356-396 5.49e-03

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 37.78  E-value: 5.49e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 238624099 356 RLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEK 396
Cdd:cd19175    1 KMKLVKTEKCGWGLVADEDINAGEFIIEYVGEVIDDKTCEE 41
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 597-697 9.30e-03

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 36.97  E-value: 9.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624099 597 VFCDEELLSETKNTSSDSLTKFNKGNVFLLDATkegnvgrFLNHSCCPNllvqnvfVETHNRNFPLVAFFTNRYVKARTE 676
Cdd:cd20071   25 ILVEKPLVSVPSNSFSLTDGLNEIGVGLFPLAS-------LLNHSCDPN-------AVVVFDGNGTLRVRALRDIKAGEE 90

                         90       100
                 ....*....|....*....|....*....
gi 238624099 677 LTWDYGYEAGTVPE--KEIF------CQC 697
Cdd:cd20071   91 LTISYIDPLLPRTErrRELLekygftCSC 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH