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Conserved domains on  [gi|237681154|ref|NP_001153723|]
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zinc finger protein 281 [Mus musculus]

Protein Classification

zf-C2H2_4 and zf-H2C2_2 domain-containing protein( domain architecture ID 10620944)

zf-C2H2_4 and zf-H2C2_2 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
272-297 4.23e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 4.23e-06
                          10        20
                  ....*....|....*....|....*.
gi 237681154  272 HLRRHVLIHTGERPFQCSQCSMGFIQ 297
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-353 5.41e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 5.41e-06
                          10        20
                  ....*....|....*....|....*.
gi 237681154  328 HMERHKRTHSGEKPYKCDTCQQYFSR 353
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
258-280 4.86e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


:

Pssm-ID: 464025  Cd Length: 24  Bit Score: 35.31  E-value: 4.86e-03
                          10        20
                  ....*....|....*....|...
gi 237681154  258 HICDHCSAAFRSSYHLRRHVLIH 280
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
272-297 4.23e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 4.23e-06
                          10        20
                  ....*....|....*....|....*.
gi 237681154  272 HLRRHVLIHTGERPFQCSQCSMGFIQ 297
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-353 5.41e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 5.41e-06
                          10        20
                  ....*....|....*....|....*.
gi 237681154  328 HMERHKRTHSGEKPYKCDTCQQYFSR 353
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
258-280 4.86e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 35.31  E-value: 4.86e-03
                          10        20
                  ....*....|....*....|...
gi 237681154  258 HICDHCSAAFRSSYHLRRHVLIH 280
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
272-297 4.23e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 4.23e-06
                          10        20
                  ....*....|....*....|....*.
gi 237681154  272 HLRRHVLIHTGERPFQCSQCSMGFIQ 297
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-353 5.41e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 5.41e-06
                          10        20
                  ....*....|....*....|....*.
gi 237681154  328 HMERHKRTHSGEKPYKCDTCQQYFSR 353
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
258-280 4.86e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 35.31  E-value: 4.86e-03
                          10        20
                  ....*....|....*....|...
gi 237681154  258 HICDHCSAAFRSSYHLRRHVLIH 280
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
286-308 8.11e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 8.11e-03
                          10        20
                  ....*....|....*....|...
gi 237681154  286 FQCSQCSMGFIQKYLLQRHEKIH 308
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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