View
Concise Results
Standard Results
Full Results
phosphoribosylformylglycinamidine synthase [Mus musculus]
Protein Classification
List of domain hits
Name
Accession
Description
Interval
E-value
PRK05297 super family
cl46903 phosphoribosylformylglycinamidine synthase; Provisional
7-1332
0e+00
phosphoribosylformylglycinamidine synthase; Provisional
TIGR01735 :Pssm-ID: 481243 [Multi-domain]
Cd Length: 1310
Bit Score: 2048.59
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 7 F YVR PS GHE G AASGRVFRR LQ E K L P T L QS V ET E L CY N V H W AAETLPWA EE MKK L MW L F G CP L VRDD vaqe PW L VP G sndl 86
Cdd:TIGR01735 1 F LRG PS ALS G FRLEKLLQK LQ T K V P E L TG V YA E F CY F V G W ESALTADE EE KLQ L LL L A G SV L EPPQ ---- SP L GR G ---- 72
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 87 LLEVGPRL NFST P A S TNIV S VCQAA GL RA VDR V E TT RRY R LS FTDHPTA E M EA ISL A A LHDRMTE QHY P DP I QS F SPQ S I 166
Cdd:TIGR01735 73 LLEVGPRL GTIS P W S SKAT S IARNC GL AK VDR I E RG RRY Y LS GAHPLSE E Q EA QAA A L LHDRMTE SVL P HE I EA F ELF S V 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 167 P A PL KGS - ID I L AE GR P ALEKANQELGLALD SWDL D FY TKRFQELQRNPS T VE VFDL AQ S NSEH S RH WF F KGQLHV DGKK 245
Cdd:TIGR01735 153 P E PL NLT t ID V L GG GR L ALEKANQELGLALD EDEI D YL TKRFQELQRNPS D VE LMMF AQ A NSEH C RH KI F NADWII DGKK 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 246 LAH SLF ES I M ST QASSNP N N V LKFC DNSS A I Q G K KV KF LRP EDS TRP SCF Q Q Q QG L R H VVFTA ETHN F PT GV APF S GA T T 325
Cdd:TIGR01735 233 QDK SLF QM I K ST HEANPE N T V SAYK DNSS V I E G H KV GR LRP DPP TRP EYR Q H Q ED L V H ILMKV ETHN H PT AI APF P GA S T 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 326 G T GG R IRD VQC TGRGA HVV AG TA G Y C FG NL H IP DYNL PWEDP s FQ Y P GNF A R PL EVA IEA SN GA SDYG N K FG E P V L A G FA 405
Cdd:TIGR01735 313 G A GG E IRD EGA TGRGA KPK AG LT G F C VS NL N IP GLEQ PWEDP - FQ K P ERI A S PL DIM IEA PL GA AAFN N E FG R P N L L G YF 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 406 R SLG L Q -- LP D GQ R R EWI KPIM FS GGIGS ME A K H VG K KPP EPG MEVVKV GGP VYR IG V GGGAASS v Q V Q G D NT S DLDF GA 483
Cdd:TIGR01735 392 R TFE L K as LP G GQ V R GYH KPIM LA GGIGS ID A E H IQ K GEI EPG ALLIVL GGP AML IG L GGGAASS - M V S G T NT A DLDF AS 470
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 484 VQRG D PEME QKMNR VI RA C VEAPGG NPI C S L HD Q GAGG NG N V L K EL SDP -- E GA I I YTSRFQ L G DP T L NA LEIW GA E Y QE 561
Cdd:TIGR01735 471 VQRG N PEME RRCQE VI DR C WQLGEK NPI I S I HD V GAGG LS N A L P EL IHD gg R GA V I DLRAVP L D DP G L SP LEIW CN E S QE 550
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 562 SNA LL L R PSDRDFLSRASA RERCP ACF VGT I TGD K R IV LVDD re CL V GKT GQGDAP LTP P - T PVDL D L DWV LGKMP QKEF 640
Cdd:TIGR01735 551 RYV LL V R AENLEIFTAICE RERCP FAV VGT A TGD G R LT LVDD -- TP V RRN GQGDAP SHF P n N PVDL P L EVL LGKMP KMTR 628
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 641 F L QRK P P V LQPL AL PP E L SVRQ AL N RVLRLPAVASKR Y L TNKV DRSVGGLVA QQ Q C VGP L QTPLADVAV V A L S HQECI G A 720
Cdd:TIGR01735 629 F V QRK A P M LQPL DI PP G L DLHE AL E RVLRLPAVASKR F L ITIG DRSVGGLVA RD Q M VGP W QTPLADVAV T A A S FDTYT G E 708
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 721 A T A L GE Q P V K S LLDPKA A ARLAV S EA L TNL VF ALV T DL R DVK C S G NWM W AA KL PGE G AAL A DA CE A MVAVMA ALG V A VDG 800
Cdd:TIGR01735 709 A M A I GE R P P K A LLDPKA S ARLAV G EA I TNL AA ALV G DL S DVK L S A NWM A AA GH PGE D AAL Y DA VK A VSELCP ALG I A IPV 788
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 801 GKDSLSM AA R VG ---- T ET V Q APGSLVISA Y A VC PD ITA TVTPDLKH PG G KG HLL Y V P L S PG QH RLGG T ALAQ C F S QLG E 876
Cdd:TIGR01735 789 GKDSLSM KT R WQ dnge T KS V T APGSLVISA F A PV PD VRK TVTPDLKH DK G DS HLL L V D L G PG KN RLGG S ALAQ V F G QLG G 868
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 877 HP PDLD L PE N L VRA F HIT QGL LK E CR L CSG HD V SDGGLVT C LLEMAFAG N CG IE VD VP A P G IHALP VLF A EE P G L V LE V Q 956
Cdd:TIGR01735 869 DC PDLD D PE R L KAF F AVM QGL VA E GL L LAY HD R SDGGLVT T LLEMAFAG H CG LD VD LD A L G DSLFA VLF N EE L G A V IQ V A 948
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 957 EA D V A G V RQRYES AGL RC L E LG HTGEA G p QA M A RISVN K A VVVE E PVG ELR AL WEETSFQL DL L QAE P R C VI EE KQ GL KE 1036
Cdd:TIGR01735 949 KP D L A A V LELLRA AGL TA L I LG IGTPT G - HP M I RISVN G A TLLS E KRS ELR DI WEETSFQL QR L RDN P E C AE EE FE GL RD 1027
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1037 R T GP SYY LP P TF P V ASVPCK P G --- G PV P R VAILRE E G S NGDREMA D AF HL AGFE V WDV T M Q DL CS G AIR LD T FRG V A FV 1113
Cdd:TIGR01735 1028 R D GP GLK LP L TF D V NEDIAA P F ink G VK P K VAILRE Q G V NGDREMA A AF DR AGFE A WDV H M S DL LA G RVH LD E FRG L A AC 1107
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1114 GGFSY A DVLG SA KGWA AAVT FNP QA R EELGR F RR RPDTFSLGVCNGCQ L L A - LL G W VGSDPSE eqaepgqdsqptqp GLL 1192
Cdd:TIGR01735 1108 GGFSY G DVLG AG KGWA KSIL FNP RL R DQFQA F FK RPDTFSLGVCNGCQ M L S n LL E W IPGTENW -------------- PHF 1173
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1193 L R H N l S G RFE S R W A T VRV EPG P AL MLRGM E GS V LPV WS AHGEGY M AFSSPELQA KIE A K GL VP L HWA DDDGNPTE Q YPLN 1272
Cdd:TIGR01735 1174 V R N N - S E RFE A R V A S VRV GES P SI MLRGM A GS R LPV AV AHGEGY A AFSSPELQA QAD A S GL AA L RYI DDDGNPTE A YPLN 1252
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1273 PNGSPGGIAGI C S Q DGR HLAL MPHPER AV R L WQ WA WRP SPF D V lp TS PWL Q LF I NARNW T 1332
Cdd:TIGR01735 1253 PNGSPGGIAGI T S C DGR VTIM MPHPER VF R A WQ NS WRP EDW D E -- DT PWL R LF R NARNW L 1310
Name
Accession
Description
Interval
E-value
FGAM_synt
TIGR01735 phosphoribosylformylglycinamidine synthase, single chain form; This model represents a ...
7-1332
0e+00
phosphoribosylformylglycinamidine synthase, single chain form; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This form is found mostly in eukaryotes and Proteobacteria. In Bacillus subtilis PurL (FGAM synthase II) and PurQ (FGAM synthase I), homologous to different parts of this model, perform the equivalent function; the unrelated small protein PurS is also required and may be a third subunit. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 188163 [Multi-domain]
Cd Length: 1310
Bit Score: 2048.59
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 7 F YVR PS GHE G AASGRVFRR LQ E K L P T L QS V ET E L CY N V H W AAETLPWA EE MKK L MW L F G CP L VRDD vaqe PW L VP G sndl 86
Cdd:TIGR01735 1 F LRG PS ALS G FRLEKLLQK LQ T K V P E L TG V YA E F CY F V G W ESALTADE EE KLQ L LL L A G SV L EPPQ ---- SP L GR G ---- 72
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 87 LLEVGPRL NFST P A S TNIV S VCQAA GL RA VDR V E TT RRY R LS FTDHPTA E M EA ISL A A LHDRMTE QHY P DP I QS F SPQ S I 166
Cdd:TIGR01735 73 LLEVGPRL GTIS P W S SKAT S IARNC GL AK VDR I E RG RRY Y LS GAHPLSE E Q EA QAA A L LHDRMTE SVL P HE I EA F ELF S V 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 167 P A PL KGS - ID I L AE GR P ALEKANQELGLALD SWDL D FY TKRFQELQRNPS T VE VFDL AQ S NSEH S RH WF F KGQLHV DGKK 245
Cdd:TIGR01735 153 P E PL NLT t ID V L GG GR L ALEKANQELGLALD EDEI D YL TKRFQELQRNPS D VE LMMF AQ A NSEH C RH KI F NADWII DGKK 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 246 LAH SLF ES I M ST QASSNP N N V LKFC DNSS A I Q G K KV KF LRP EDS TRP SCF Q Q Q QG L R H VVFTA ETHN F PT GV APF S GA T T 325
Cdd:TIGR01735 233 QDK SLF QM I K ST HEANPE N T V SAYK DNSS V I E G H KV GR LRP DPP TRP EYR Q H Q ED L V H ILMKV ETHN H PT AI APF P GA S T 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 326 G T GG R IRD VQC TGRGA HVV AG TA G Y C FG NL H IP DYNL PWEDP s FQ Y P GNF A R PL EVA IEA SN GA SDYG N K FG E P V L A G FA 405
Cdd:TIGR01735 313 G A GG E IRD EGA TGRGA KPK AG LT G F C VS NL N IP GLEQ PWEDP - FQ K P ERI A S PL DIM IEA PL GA AAFN N E FG R P N L L G YF 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 406 R SLG L Q -- LP D GQ R R EWI KPIM FS GGIGS ME A K H VG K KPP EPG MEVVKV GGP VYR IG V GGGAASS v Q V Q G D NT S DLDF GA 483
Cdd:TIGR01735 392 R TFE L K as LP G GQ V R GYH KPIM LA GGIGS ID A E H IQ K GEI EPG ALLIVL GGP AML IG L GGGAASS - M V S G T NT A DLDF AS 470
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 484 VQRG D PEME QKMNR VI RA C VEAPGG NPI C S L HD Q GAGG NG N V L K EL SDP -- E GA I I YTSRFQ L G DP T L NA LEIW GA E Y QE 561
Cdd:TIGR01735 471 VQRG N PEME RRCQE VI DR C WQLGEK NPI I S I HD V GAGG LS N A L P EL IHD gg R GA V I DLRAVP L D DP G L SP LEIW CN E S QE 550
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 562 SNA LL L R PSDRDFLSRASA RERCP ACF VGT I TGD K R IV LVDD re CL V GKT GQGDAP LTP P - T PVDL D L DWV LGKMP QKEF 640
Cdd:TIGR01735 551 RYV LL V R AENLEIFTAICE RERCP FAV VGT A TGD G R LT LVDD -- TP V RRN GQGDAP SHF P n N PVDL P L EVL LGKMP KMTR 628
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 641 F L QRK P P V LQPL AL PP E L SVRQ AL N RVLRLPAVASKR Y L TNKV DRSVGGLVA QQ Q C VGP L QTPLADVAV V A L S HQECI G A 720
Cdd:TIGR01735 629 F V QRK A P M LQPL DI PP G L DLHE AL E RVLRLPAVASKR F L ITIG DRSVGGLVA RD Q M VGP W QTPLADVAV T A A S FDTYT G E 708
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 721 A T A L GE Q P V K S LLDPKA A ARLAV S EA L TNL VF ALV T DL R DVK C S G NWM W AA KL PGE G AAL A DA CE A MVAVMA ALG V A VDG 800
Cdd:TIGR01735 709 A M A I GE R P P K A LLDPKA S ARLAV G EA I TNL AA ALV G DL S DVK L S A NWM A AA GH PGE D AAL Y DA VK A VSELCP ALG I A IPV 788
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 801 GKDSLSM AA R VG ---- T ET V Q APGSLVISA Y A VC PD ITA TVTPDLKH PG G KG HLL Y V P L S PG QH RLGG T ALAQ C F S QLG E 876
Cdd:TIGR01735 789 GKDSLSM KT R WQ dnge T KS V T APGSLVISA F A PV PD VRK TVTPDLKH DK G DS HLL L V D L G PG KN RLGG S ALAQ V F G QLG G 868
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 877 HP PDLD L PE N L VRA F HIT QGL LK E CR L CSG HD V SDGGLVT C LLEMAFAG N CG IE VD VP A P G IHALP VLF A EE P G L V LE V Q 956
Cdd:TIGR01735 869 DC PDLD D PE R L KAF F AVM QGL VA E GL L LAY HD R SDGGLVT T LLEMAFAG H CG LD VD LD A L G DSLFA VLF N EE L G A V IQ V A 948
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 957 EA D V A G V RQRYES AGL RC L E LG HTGEA G p QA M A RISVN K A VVVE E PVG ELR AL WEETSFQL DL L QAE P R C VI EE KQ GL KE 1036
Cdd:TIGR01735 949 KP D L A A V LELLRA AGL TA L I LG IGTPT G - HP M I RISVN G A TLLS E KRS ELR DI WEETSFQL QR L RDN P E C AE EE FE GL RD 1027
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1037 R T GP SYY LP P TF P V ASVPCK P G --- G PV P R VAILRE E G S NGDREMA D AF HL AGFE V WDV T M Q DL CS G AIR LD T FRG V A FV 1113
Cdd:TIGR01735 1028 R D GP GLK LP L TF D V NEDIAA P F ink G VK P K VAILRE Q G V NGDREMA A AF DR AGFE A WDV H M S DL LA G RVH LD E FRG L A AC 1107
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1114 GGFSY A DVLG SA KGWA AAVT FNP QA R EELGR F RR RPDTFSLGVCNGCQ L L A - LL G W VGSDPSE eqaepgqdsqptqp GLL 1192
Cdd:TIGR01735 1108 GGFSY G DVLG AG KGWA KSIL FNP RL R DQFQA F FK RPDTFSLGVCNGCQ M L S n LL E W IPGTENW -------------- PHF 1173
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1193 L R H N l S G RFE S R W A T VRV EPG P AL MLRGM E GS V LPV WS AHGEGY M AFSSPELQA KIE A K GL VP L HWA DDDGNPTE Q YPLN 1272
Cdd:TIGR01735 1174 V R N N - S E RFE A R V A S VRV GES P SI MLRGM A GS R LPV AV AHGEGY A AFSSPELQA QAD A S GL AA L RYI DDDGNPTE A YPLN 1252
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1273 PNGSPGGIAGI C S Q DGR HLAL MPHPER AV R L WQ WA WRP SPF D V lp TS PWL Q LF I NARNW T 1332
Cdd:TIGR01735 1253 PNGSPGGIAGI T S C DGR VTIM MPHPER VF R A WQ NS WRP EDW D E -- DT PWL R LF R NARNW L 1310
PLN03206
PLN03206 phosphoribosylformylglycinamidine synthase; Provisional
24-1331
0e+00
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 178745 [Multi-domain]
Cd Length: 1307
Bit Score: 1772.38
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 24 R RL Q E K LPT - LQ S V ETE L C Y NV HWAAETLP wa E EMKK L M WL FGCPLVRDDVAQ E PW L VP ---- G S N DLLL EVGPRL N F S T 98
Cdd:PLN03206 5 R KV Q T K VSN d IV S I ETE Q C F NV GLESPLSA -- E KLET L K WL LRETFEPENLGT E SF L EA kkse G L N AVVV EVGPRL S F T T 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 99 PA STN I VS V C Q A A GL RA V D R V E TT RRY R L SFTDHPTAEMEAISL A AL HDRMTE QH YP D P IQ SF SPQSI P A P LK g SIDILA 178
Cdd:PLN03206 83 AW STN A VS I C S A C GL TE V T R L E RS RRY L L FSSSPLDESQINAFA A MV HDRMTE CV YP Q P LT SF ESGVV P E P VY - TVPVME 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 179 EGR P ALE KA N Q E L GLA L D SW DLD F YT KR F QE - LQ R N P ST VE V FD L AQSNSEHSRHWFF K G Q L HV DG KKLAHS LF ESIMS T 257
Cdd:PLN03206 162 EGR A ALE EI N K E M GLA F D EQ DLD Y YT RL F RD d IK R D P TN VE L FD I AQSNSEHSRHWFF S G K L VI DG QPMPKT LF QMVKD T 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 258 QA s S NPNN - V LK F C DNSSAI Q G KK V KF LRP EDSTR PS CFQQQQGLRHVVF TAETHNFP TG VAP FS GA T TG T GGRIRD VQC 336
Cdd:PLN03206 242 LK - A NPNN s V IG F K DNSSAI R G FV V QP LRP VSPGS PS PLAPVDRDLDILL TAETHNFP CA VAP YP GA E TG A GGRIRD THA 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 337 TGRG AH VVAGTAGYC F GNL H I PDYNL PWED P SF Q YP G N F A R PL EVA I E ASNGASDYGNKFGEP VLA G FA R SL G LQ LP D G Q 416
Cdd:PLN03206 321 TGRG SF VVAGTAGYC V GNL R I EGSYA PWED S SF V YP S N L A S PL QIL I D ASNGASDYGNKFGEP LIQ G YT R TF G MR LP N G E 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 417 RREW I KPIMFSGGIG SMEAK H VG K KP P EP GM E VVK V GGP V YRIG V GGGAASS V q V Q G D N TSD LDF G AVQRGD P EM E QK MN 496
Cdd:PLN03206 401 RREW L KPIMFSGGIG QIDHT H LT K GE P DI GM L VVK I GGP A YRIG M GGGAASS M - V S G Q N DAE LDF N AVQRGD A EM S QK LY 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 497 RV I RACVE APGG NPI C S L HDQGAGGN G NV L KE LSD P E GA I I YTSRFQL GD P TL NA LEIWGAEYQE SN ALL LR P SD RD F L S 576
Cdd:PLN03206 480 RV V RACVE MGED NPI V S I HDQGAGGN C NV V KE IIY P K GA E I DIRAVVV GD H TL SV LEIWGAEYQE QD ALL IK P ES RD L L Q 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 577 RASA RERC PACFV GTI T G DK R I VLVD DR ec LVG K TGQGDA P l T PP TP VDLDL DW VLG K MPQK E F FLQ R KPPV L Q PL AL PP 656
Cdd:PLN03206 560 SICD RERC SMAVI GTI D G SG R V VLVD SA -- APE K CEANGL P - P PP PA VDLDL EK VLG D MPQK T F EFK R VANK L E PL DI PP 636
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 657 ELS V RQ AL N RVLRLP A V A SKR Y LT N KVDR S V G GLVAQQQ C VGPLQ T PLADVAV V A LS H QECI G A A T A L GEQP V K S L L DPK 736
Cdd:PLN03206 637 GIT V MD AL K RVLRLP S V C SKR F LT T KVDR C V T GLVAQQQ T VGPLQ I PLADVAV I A QT H TGLT G G A C A I GEQP I K G L V DPK 716
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 737 A A ARLAV S EALTNLV F A L VT D L R DVK C SGNWM W AAKL P GEGA ALA DA CE A MVAV M AA LGVA V DGGKDSLSMAA RV G T E T V 816
Cdd:PLN03206 717 A M ARLAV G EALTNLV W A K VT A L S DVK A SGNWM Y AAKL D GEGA DMY DA AV A LRDA M IE LGVA I DGGKDSLSMAA QA G G E V V 796
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 817 Q APG S LVISAY AV CPDIT A TVTPDLK H p G GK G H LL Y V P L SP G QH RLGG T ALAQ CFS Q L G EHP PDLD LPEN L VR AF HI TQ G 896
Cdd:PLN03206 797 K APG N LVISAY VT CPDIT K TVTPDLK L - G DD G V LL H V D L GK G KR RLGG S ALAQ AYD Q I G DDC PDLD DVAY L KK AF EA TQ D 875
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 897 L LKECRLCS GHD V SDGGLV TC LLEMAFAGNCGI E VD V P AP G IH A LPV LFAEE P GLVLEV QEADVAG V RQRYES AG LRCLE 976
Cdd:PLN03206 876 L IAKRLISA GHD I SDGGLV VT LLEMAFAGNCGI N VD L P SS G HS A FET LFAEE L GLVLEV SRKNLDA V MEKLAA AG VTAEV 955
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 977 L G HT g E A G P qa MARIS V NK A VVVE E PVGE LR AL WEETSFQL DL LQ AEPR CV IE EK Q GLK E R TG P SYY L P -- P T F PVASVP 1054
Cdd:PLN03206 956 I G QV - T A S P -- LIEVK V DG A TCLS E KTAS LR DM WEETSFQL EK LQ RLES CV AQ EK E GLK S R KA P TWK L S ft P A F TDKKIM 1032
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1055 CKPGG pv P R VAI L REEGSNGDREMA D AF HL AGFE V WDVTM Q DL CS G A I R LD T FRG VA FVGGFSYADVL G SAKGWA AAVT F 1134
Cdd:PLN03206 1033 NATSK -- P K VAI I REEGSNGDREMA A AF YA AGFE P WDVTM S DL LN G R I S LD D FRG IV FVGGFSYADVL D SAKGWA GSIR F 1110
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1135 N PQAREELGR F RR RPDTFSLGVCNGCQL L ALLGWV GS dp SEEQAEP G QDSQ P T QP GLL lr HN L SGRFE S R WAT V RV E PG P 1214
Cdd:PLN03206 1111 N EPLLQQFQE F YN RPDTFSLGVCNGCQL M ALLGWV PG -- PQVGGGL G AGGD P S QP RFV -- HN E SGRFE C R FTS V TI E DS P 1186
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1215 A L ML R GMEGS V L P VW S AHGEG YMA F SSPELQAKIEAKG L V P LHWA DDDG N PTEQYP L NPNGSP G GIA GI CS Q DGRHLA L M 1294
Cdd:PLN03206 1187 A I ML K GMEGS T L G VW A AHGEG RAY F PDESVLDEVLKSN L A P VRYC DDDG E PTEQYP F NPNGSP L GIA AL CS P DGRHLA M M 1266
1290 1300 1310
....*....|....*....|....*....|....*....
gi 226958458 1295 PHPER AVRL WQ WA W R P SPFD V L P T -- SPWL QL F I NAR N W 1331
Cdd:PLN03206 1267 PHPER CFLM WQ FP W Y P KEWG V D P A gp SPWL KM F Q NAR E W 1305
PurL1
COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and ...
177-1013
0e+00
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439816 [Multi-domain]
Cd Length: 747
Bit Score: 669.06
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 177 L AE GR P ALE K AN Q ELGLAL DSWDL D FYTKR fqe L Q RNP ST VE VFDLA Q SN SEH SRHWFFKGQ L hvdg K K L A hslfesims 256
Cdd:COG0046 6 L EG GR E ALE E AN R ELGLAL SDDEY D YIVEI --- L G RNP TD VE LGMFS Q MW SEH CSYKSSNAL L ---- K S L P --------- 69
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 257 tqa SSN P NNVLKFC DN SSAIQGK kvkflrp EDS trpscfqqqqglr H VVF TA E T HN F P TGVA P FS GA T TG T GG R IRD VQ c 336
Cdd:COG0046 70 --- TEG P RVLSGPG DN AGVVDIG ------- DGL ------------- A VVF KV E S HN H P SAIE P YQ GA A TG V GG I IRD IF - 125
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 337 t G R GA HVV AG TAGYC FGNL HI P D ynlpwedpsfqypgnf A R P LEVA I EASN G AS DYGN K FG E P VLA G FA R S lglqlp D GQ 416
Cdd:COG0046 126 - G M GA RPI AG LDSLR FGNL DQ P P ---------------- A S P RYIL I GVVA G IA DYGN C FG V P TVG G EV R F ------ D ES 182
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 417 RRE wi K P IMFS GG I G SME A K H VG K - K P P EP G ME VV K VGGP VY R I G V GG GAAS S V q VQ G DN t S D LD FG AVQ R GDP E ME QKM 495
Cdd:COG0046 183 YEG -- N P LVNA GG V G IIR A D H IF K a K A P GV G NK VV Y VGGP TG R D G I GG ATFA S E - EL G ED - S E LD RP AVQ V GDP F ME KRL 258
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 496 NRV I RACVEA pgg NP I CSLH D Q GAGG NGNVLK E LSD -- PE GA I I YTSRFQ L GD P TLNAL EIW GA E Y QE SNA L LLR P SDRD 573
Cdd:COG0046 259 IEA I LELGDT --- GL I VGIQ D M GAGG LSSASS E MAA kg GL GA E I DLDKVP L RE P GMSPY EIW LS E S QE RML L VVK P EKLE 335
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 574 FLSRASA R E R C PA CFV G TI T G D K R I V LV D DR E clvgktgqgdapltpp T PV DL D LD WVL G KM P QKEFFLQ R k P PV L Q PL A 653
Cdd:COG0046 336 EFEAIFE R W R L PA AVI G EV T D D G R L V VT D HG E ---------------- T VA DL P LD FLA G GA P KYHRPAK R - P AY L E PL D 398
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 654 LP PELSVRQ AL N R V L RL P A VASK RY L TNKV DR S VGG LVAQQQ cvgplqt PL AD V AVV ALSHQE c I G A A TAL GE Q P VKS LL 733
Cdd:COG0046 399 LP EPIDLEE AL L R L L SS P N VASK EW L YRQY DR E VGG NTVRDP ------- GV AD A AVV RVDGTY - K G L A MST GE N P RYA LL 470
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 734 DP K A A AR L AV S EA LT NL VFALVTD L r DVKCSG NW MWAA K l P G E G A A L AD A CEAMVAVMA ALG VA V DG G KD SL SMAARV G t 813
Cdd:COG0046 471 DP Y A G AR M AV A EA AR NL AAVGAEP L - AITDCL NW GNPE K - P E E M A Q L VE A VKGLADACR ALG IP V PS G NV SL YNETKD G - 547
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 814 e T V QA P GSL VI S A YAVCP D ITA TVTPDLK HP ggk G H LLY V p LSPGQHR LGG TAL AQ CFS QLG EH PPD L D l P E NLVRA F HI 893
Cdd:COG0046 548 - K V AI P PTP VI G A VGLVD D VRK TVTPDLK KE --- G D LLY L - IGETKNE LGG SEY AQ VLG QLG GE PPD V D - L E AEKAL F EA 621
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 894 T Q G L LK E CRLCSG HDVSDGGL VTC L L EMAFAG NC G IEV D VP A - PGIHALPV LF A E EP G - L V LE V QEA D VAG V RQRYES AG 971
Cdd:COG0046 622 V Q E L IR E GLILAA HDVSDGGL AVA L A EMAFAG GL G ADI D LD A l GDLRPDAA LF S E SQ G r A V VQ V APE D AEA V EALLAE AG 701
810 820 830 840
....*....|....*....|....*....|....*....|..
gi 226958458 972 L RCLEL G HTGEAG pqa MAR I SVNKAVVVEEPVG ELR AL WEET 1013
Cdd:COG0046 702 L PAHVI G TVTGDD --- RLV I RRGGETLLSLSLA ELR DA WEET 740
GATase_5
pfam13507 CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not ...
1062-1331
4.94e-140
CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not found in pfam00310, pfam07685 and pfam13230.
Pssm-ID: 463904 [Multi-domain]
Cd Length: 260
Bit Score: 427.30
E-value: 4.94e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1062 PRVAILRE E G S NG DR EMA D AF HL AGF EVW DV T M Q DL C SG AIR LD T F R G V A FV GGFSY A DVLGS A KGWAA AVT FNP QA R EE 1141
Cdd:pfam13507 2 PRVAILRE P G T NG EY EMA A AF ER AGF DAV DV H M S DL L SG RVS LD D F Q G L A AP GGFSY G DVLGS G KGWAA SIL FNP KL R DA 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1142 LGR F RR RPDTFSLG V CNGCQLL AL LG WV gsdpseeqae PG QDSQPTQPGLL L RH N L SGRFESRW AT V RV - E PG P ALM LRG 1220
Cdd:pfam13507 82 FEA F FN RPDTFSLG I CNGCQLL SK LG LI ---------- PG GEGDLAERWPT L TR N D SGRFESRW VN V KI s E KS P SVF LRG 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1221 M E GS V LPV ws AHGEG YMA F S S P E LQ A KI EA K G L V P L HWA D DD GNPTE Q YP L NPNGSP G GIAGICS Q DGR H L A LMPHPER A 1300
Cdd:pfam13507 152 M D GS G LPV -- AHGEG RFV F R S E E VL A RL EA N G Q V A L RYV D NA GNPTE E YP F NPNGSP L GIAGICS P DGR V L G LMPHPER V 229
250 260 270
....*....|....*....|....*....|.
gi 226958458 1301 V R L WQW AWR P s P FDVLPT SPWL Q LF I NAR N W 1331
Cdd:pfam13507 230 F R P WQW PHW P - P GEWEEV SPWL R LF R NAR K W 259
PurL_repeat1
cd02203 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. ...
218-608
2.88e-123
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100034 [Multi-domain]
Cd Length: 313
Bit Score: 384.52
E-value: 2.88e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 218 E VFDL AQ SN SEH S RH WF FK gqlhvdgkklah SL FES I M stqassnpnnvlkfcdnssaiqgkkvkflrpedstrpscfqq 297
Cdd:cd02203 1 E LGMF AQ MW SEH C RH KS FK ------------ SL LKM I W ------------------------------------------ 26
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 298 qqglr H VVF TA ETHN F P TGVA PF S GA T TG T GG R IRD VQCT G rg A HVV A GTA G YC FG N L H IP D Y nlpwedpsfq Y P GNFAR 377
Cdd:cd02203 27 ----- A VVF KV ETHN H P SAIE PF G GA A TG V GG I IRD ILSM G -- A RPI A LLD G LR FG D L D IP G Y ---------- E P KGKLS 89
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 378 P LEVAIEASN G A SDYGN KF G E P VLA G FA R S lglqlp D GQR re WIK P IMFS G GI G SMEAK H VG K - K P P E PG ME VV K VGG PV 456
Cdd:cd02203 90 P RRILDGVVA G I SDYGN CI G I P TVG G EV R F ------ D PSY -- YGN P LVNV G CV G IVPKD H IV K s K A P G PG DL VV L VGG RT 161
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 457 Y R I G V GG GAA SS VQV q GD N T S D LD FG AVQ R GDP E ME Q K MNRV I RACV E A pgg NP I CSLH D Q GAGG NGNVLK E LSD -- PE G 534
Cdd:cd02203 162 G R D G I GG ATF SS KEL - SE N S S E LD RP AVQ V GDP F ME K K LQEA I LEAR E T --- GL I VGIQ D L GAGG LSSAVS E MAA kg GL G 237
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226958458 535 A I I YTSRFQ L GD P TLNAL EIW GA E Y QE SNA L LLR P S D RDFLSRASAR E RCP A CFV G TI T G D K R IV L VDDR E CLV 608
Cdd:cd02203 238 A E I DLDKVP L RE P GMSPW EIW IS E S QE RML L VVP P E D LEEFLAICKK E DLE A AVI G EV T D D G R LR L YYKG E VVA 311
Name
Accession
Description
Interval
E-value
FGAM_synt
TIGR01735 phosphoribosylformylglycinamidine synthase, single chain form; This model represents a ...
7-1332
0e+00
phosphoribosylformylglycinamidine synthase, single chain form; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This form is found mostly in eukaryotes and Proteobacteria. In Bacillus subtilis PurL (FGAM synthase II) and PurQ (FGAM synthase I), homologous to different parts of this model, perform the equivalent function; the unrelated small protein PurS is also required and may be a third subunit. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 188163 [Multi-domain]
Cd Length: 1310
Bit Score: 2048.59
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 7 F YVR PS GHE G AASGRVFRR LQ E K L P T L QS V ET E L CY N V H W AAETLPWA EE MKK L MW L F G CP L VRDD vaqe PW L VP G sndl 86
Cdd:TIGR01735 1 F LRG PS ALS G FRLEKLLQK LQ T K V P E L TG V YA E F CY F V G W ESALTADE EE KLQ L LL L A G SV L EPPQ ---- SP L GR G ---- 72
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 87 LLEVGPRL NFST P A S TNIV S VCQAA GL RA VDR V E TT RRY R LS FTDHPTA E M EA ISL A A LHDRMTE QHY P DP I QS F SPQ S I 166
Cdd:TIGR01735 73 LLEVGPRL GTIS P W S SKAT S IARNC GL AK VDR I E RG RRY Y LS GAHPLSE E Q EA QAA A L LHDRMTE SVL P HE I EA F ELF S V 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 167 P A PL KGS - ID I L AE GR P ALEKANQELGLALD SWDL D FY TKRFQELQRNPS T VE VFDL AQ S NSEH S RH WF F KGQLHV DGKK 245
Cdd:TIGR01735 153 P E PL NLT t ID V L GG GR L ALEKANQELGLALD EDEI D YL TKRFQELQRNPS D VE LMMF AQ A NSEH C RH KI F NADWII DGKK 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 246 LAH SLF ES I M ST QASSNP N N V LKFC DNSS A I Q G K KV KF LRP EDS TRP SCF Q Q Q QG L R H VVFTA ETHN F PT GV APF S GA T T 325
Cdd:TIGR01735 233 QDK SLF QM I K ST HEANPE N T V SAYK DNSS V I E G H KV GR LRP DPP TRP EYR Q H Q ED L V H ILMKV ETHN H PT AI APF P GA S T 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 326 G T GG R IRD VQC TGRGA HVV AG TA G Y C FG NL H IP DYNL PWEDP s FQ Y P GNF A R PL EVA IEA SN GA SDYG N K FG E P V L A G FA 405
Cdd:TIGR01735 313 G A GG E IRD EGA TGRGA KPK AG LT G F C VS NL N IP GLEQ PWEDP - FQ K P ERI A S PL DIM IEA PL GA AAFN N E FG R P N L L G YF 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 406 R SLG L Q -- LP D GQ R R EWI KPIM FS GGIGS ME A K H VG K KPP EPG MEVVKV GGP VYR IG V GGGAASS v Q V Q G D NT S DLDF GA 483
Cdd:TIGR01735 392 R TFE L K as LP G GQ V R GYH KPIM LA GGIGS ID A E H IQ K GEI EPG ALLIVL GGP AML IG L GGGAASS - M V S G T NT A DLDF AS 470
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 484 VQRG D PEME QKMNR VI RA C VEAPGG NPI C S L HD Q GAGG NG N V L K EL SDP -- E GA I I YTSRFQ L G DP T L NA LEIW GA E Y QE 561
Cdd:TIGR01735 471 VQRG N PEME RRCQE VI DR C WQLGEK NPI I S I HD V GAGG LS N A L P EL IHD gg R GA V I DLRAVP L D DP G L SP LEIW CN E S QE 550
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 562 SNA LL L R PSDRDFLSRASA RERCP ACF VGT I TGD K R IV LVDD re CL V GKT GQGDAP LTP P - T PVDL D L DWV LGKMP QKEF 640
Cdd:TIGR01735 551 RYV LL V R AENLEIFTAICE RERCP FAV VGT A TGD G R LT LVDD -- TP V RRN GQGDAP SHF P n N PVDL P L EVL LGKMP KMTR 628
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 641 F L QRK P P V LQPL AL PP E L SVRQ AL N RVLRLPAVASKR Y L TNKV DRSVGGLVA QQ Q C VGP L QTPLADVAV V A L S HQECI G A 720
Cdd:TIGR01735 629 F V QRK A P M LQPL DI PP G L DLHE AL E RVLRLPAVASKR F L ITIG DRSVGGLVA RD Q M VGP W QTPLADVAV T A A S FDTYT G E 708
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 721 A T A L GE Q P V K S LLDPKA A ARLAV S EA L TNL VF ALV T DL R DVK C S G NWM W AA KL PGE G AAL A DA CE A MVAVMA ALG V A VDG 800
Cdd:TIGR01735 709 A M A I GE R P P K A LLDPKA S ARLAV G EA I TNL AA ALV G DL S DVK L S A NWM A AA GH PGE D AAL Y DA VK A VSELCP ALG I A IPV 788
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 801 GKDSLSM AA R VG ---- T ET V Q APGSLVISA Y A VC PD ITA TVTPDLKH PG G KG HLL Y V P L S PG QH RLGG T ALAQ C F S QLG E 876
Cdd:TIGR01735 789 GKDSLSM KT R WQ dnge T KS V T APGSLVISA F A PV PD VRK TVTPDLKH DK G DS HLL L V D L G PG KN RLGG S ALAQ V F G QLG G 868
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 877 HP PDLD L PE N L VRA F HIT QGL LK E CR L CSG HD V SDGGLVT C LLEMAFAG N CG IE VD VP A P G IHALP VLF A EE P G L V LE V Q 956
Cdd:TIGR01735 869 DC PDLD D PE R L KAF F AVM QGL VA E GL L LAY HD R SDGGLVT T LLEMAFAG H CG LD VD LD A L G DSLFA VLF N EE L G A V IQ V A 948
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 957 EA D V A G V RQRYES AGL RC L E LG HTGEA G p QA M A RISVN K A VVVE E PVG ELR AL WEETSFQL DL L QAE P R C VI EE KQ GL KE 1036
Cdd:TIGR01735 949 KP D L A A V LELLRA AGL TA L I LG IGTPT G - HP M I RISVN G A TLLS E KRS ELR DI WEETSFQL QR L RDN P E C AE EE FE GL RD 1027
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1037 R T GP SYY LP P TF P V ASVPCK P G --- G PV P R VAILRE E G S NGDREMA D AF HL AGFE V WDV T M Q DL CS G AIR LD T FRG V A FV 1113
Cdd:TIGR01735 1028 R D GP GLK LP L TF D V NEDIAA P F ink G VK P K VAILRE Q G V NGDREMA A AF DR AGFE A WDV H M S DL LA G RVH LD E FRG L A AC 1107
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1114 GGFSY A DVLG SA KGWA AAVT FNP QA R EELGR F RR RPDTFSLGVCNGCQ L L A - LL G W VGSDPSE eqaepgqdsqptqp GLL 1192
Cdd:TIGR01735 1108 GGFSY G DVLG AG KGWA KSIL FNP RL R DQFQA F FK RPDTFSLGVCNGCQ M L S n LL E W IPGTENW -------------- PHF 1173
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1193 L R H N l S G RFE S R W A T VRV EPG P AL MLRGM E GS V LPV WS AHGEGY M AFSSPELQA KIE A K GL VP L HWA DDDGNPTE Q YPLN 1272
Cdd:TIGR01735 1174 V R N N - S E RFE A R V A S VRV GES P SI MLRGM A GS R LPV AV AHGEGY A AFSSPELQA QAD A S GL AA L RYI DDDGNPTE A YPLN 1252
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1273 PNGSPGGIAGI C S Q DGR HLAL MPHPER AV R L WQ WA WRP SPF D V lp TS PWL Q LF I NARNW T 1332
Cdd:TIGR01735 1253 PNGSPGGIAGI T S C DGR VTIM MPHPER VF R A WQ NS WRP EDW D E -- DT PWL R LF R NARNW L 1310
PLN03206
PLN03206 phosphoribosylformylglycinamidine synthase; Provisional
24-1331
0e+00
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 178745 [Multi-domain]
Cd Length: 1307
Bit Score: 1772.38
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 24 R RL Q E K LPT - LQ S V ETE L C Y NV HWAAETLP wa E EMKK L M WL FGCPLVRDDVAQ E PW L VP ---- G S N DLLL EVGPRL N F S T 98
Cdd:PLN03206 5 R KV Q T K VSN d IV S I ETE Q C F NV GLESPLSA -- E KLET L K WL LRETFEPENLGT E SF L EA kkse G L N AVVV EVGPRL S F T T 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 99 PA STN I VS V C Q A A GL RA V D R V E TT RRY R L SFTDHPTAEMEAISL A AL HDRMTE QH YP D P IQ SF SPQSI P A P LK g SIDILA 178
Cdd:PLN03206 83 AW STN A VS I C S A C GL TE V T R L E RS RRY L L FSSSPLDESQINAFA A MV HDRMTE CV YP Q P LT SF ESGVV P E P VY - TVPVME 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 179 EGR P ALE KA N Q E L GLA L D SW DLD F YT KR F QE - LQ R N P ST VE V FD L AQSNSEHSRHWFF K G Q L HV DG KKLAHS LF ESIMS T 257
Cdd:PLN03206 162 EGR A ALE EI N K E M GLA F D EQ DLD Y YT RL F RD d IK R D P TN VE L FD I AQSNSEHSRHWFF S G K L VI DG QPMPKT LF QMVKD T 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 258 QA s S NPNN - V LK F C DNSSAI Q G KK V KF LRP EDSTR PS CFQQQQGLRHVVF TAETHNFP TG VAP FS GA T TG T GGRIRD VQC 336
Cdd:PLN03206 242 LK - A NPNN s V IG F K DNSSAI R G FV V QP LRP VSPGS PS PLAPVDRDLDILL TAETHNFP CA VAP YP GA E TG A GGRIRD THA 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 337 TGRG AH VVAGTAGYC F GNL H I PDYNL PWED P SF Q YP G N F A R PL EVA I E ASNGASDYGNKFGEP VLA G FA R SL G LQ LP D G Q 416
Cdd:PLN03206 321 TGRG SF VVAGTAGYC V GNL R I EGSYA PWED S SF V YP S N L A S PL QIL I D ASNGASDYGNKFGEP LIQ G YT R TF G MR LP N G E 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 417 RREW I KPIMFSGGIG SMEAK H VG K KP P EP GM E VVK V GGP V YRIG V GGGAASS V q V Q G D N TSD LDF G AVQRGD P EM E QK MN 496
Cdd:PLN03206 401 RREW L KPIMFSGGIG QIDHT H LT K GE P DI GM L VVK I GGP A YRIG M GGGAASS M - V S G Q N DAE LDF N AVQRGD A EM S QK LY 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 497 RV I RACVE APGG NPI C S L HDQGAGGN G NV L KE LSD P E GA I I YTSRFQL GD P TL NA LEIWGAEYQE SN ALL LR P SD RD F L S 576
Cdd:PLN03206 480 RV V RACVE MGED NPI V S I HDQGAGGN C NV V KE IIY P K GA E I DIRAVVV GD H TL SV LEIWGAEYQE QD ALL IK P ES RD L L Q 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 577 RASA RERC PACFV GTI T G DK R I VLVD DR ec LVG K TGQGDA P l T PP TP VDLDL DW VLG K MPQK E F FLQ R KPPV L Q PL AL PP 656
Cdd:PLN03206 560 SICD RERC SMAVI GTI D G SG R V VLVD SA -- APE K CEANGL P - P PP PA VDLDL EK VLG D MPQK T F EFK R VANK L E PL DI PP 636
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 657 ELS V RQ AL N RVLRLP A V A SKR Y LT N KVDR S V G GLVAQQQ C VGPLQ T PLADVAV V A LS H QECI G A A T A L GEQP V K S L L DPK 736
Cdd:PLN03206 637 GIT V MD AL K RVLRLP S V C SKR F LT T KVDR C V T GLVAQQQ T VGPLQ I PLADVAV I A QT H TGLT G G A C A I GEQP I K G L V DPK 716
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 737 A A ARLAV S EALTNLV F A L VT D L R DVK C SGNWM W AAKL P GEGA ALA DA CE A MVAV M AA LGVA V DGGKDSLSMAA RV G T E T V 816
Cdd:PLN03206 717 A M ARLAV G EALTNLV W A K VT A L S DVK A SGNWM Y AAKL D GEGA DMY DA AV A LRDA M IE LGVA I DGGKDSLSMAA QA G G E V V 796
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 817 Q APG S LVISAY AV CPDIT A TVTPDLK H p G GK G H LL Y V P L SP G QH RLGG T ALAQ CFS Q L G EHP PDLD LPEN L VR AF HI TQ G 896
Cdd:PLN03206 797 K APG N LVISAY VT CPDIT K TVTPDLK L - G DD G V LL H V D L GK G KR RLGG S ALAQ AYD Q I G DDC PDLD DVAY L KK AF EA TQ D 875
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 897 L LKECRLCS GHD V SDGGLV TC LLEMAFAGNCGI E VD V P AP G IH A LPV LFAEE P GLVLEV QEADVAG V RQRYES AG LRCLE 976
Cdd:PLN03206 876 L IAKRLISA GHD I SDGGLV VT LLEMAFAGNCGI N VD L P SS G HS A FET LFAEE L GLVLEV SRKNLDA V MEKLAA AG VTAEV 955
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 977 L G HT g E A G P qa MARIS V NK A VVVE E PVGE LR AL WEETSFQL DL LQ AEPR CV IE EK Q GLK E R TG P SYY L P -- P T F PVASVP 1054
Cdd:PLN03206 956 I G QV - T A S P -- LIEVK V DG A TCLS E KTAS LR DM WEETSFQL EK LQ RLES CV AQ EK E GLK S R KA P TWK L S ft P A F TDKKIM 1032
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1055 CKPGG pv P R VAI L REEGSNGDREMA D AF HL AGFE V WDVTM Q DL CS G A I R LD T FRG VA FVGGFSYADVL G SAKGWA AAVT F 1134
Cdd:PLN03206 1033 NATSK -- P K VAI I REEGSNGDREMA A AF YA AGFE P WDVTM S DL LN G R I S LD D FRG IV FVGGFSYADVL D SAKGWA GSIR F 1110
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1135 N PQAREELGR F RR RPDTFSLGVCNGCQL L ALLGWV GS dp SEEQAEP G QDSQ P T QP GLL lr HN L SGRFE S R WAT V RV E PG P 1214
Cdd:PLN03206 1111 N EPLLQQFQE F YN RPDTFSLGVCNGCQL M ALLGWV PG -- PQVGGGL G AGGD P S QP RFV -- HN E SGRFE C R FTS V TI E DS P 1186
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1215 A L ML R GMEGS V L P VW S AHGEG YMA F SSPELQAKIEAKG L V P LHWA DDDG N PTEQYP L NPNGSP G GIA GI CS Q DGRHLA L M 1294
Cdd:PLN03206 1187 A I ML K GMEGS T L G VW A AHGEG RAY F PDESVLDEVLKSN L A P VRYC DDDG E PTEQYP F NPNGSP L GIA AL CS P DGRHLA M M 1266
1290 1300 1310
....*....|....*....|....*....|....*....
gi 226958458 1295 PHPER AVRL WQ WA W R P SPFD V L P T -- SPWL QL F I NAR N W 1331
Cdd:PLN03206 1267 PHPER CFLM WQ FP W Y P KEWG V D P A gp SPWL KM F Q NAR E W 1305
PRK05297
PRK05297 phosphoribosylformylglycinamidine synthase; Provisional
24-1331
0e+00
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 235394 [Multi-domain]
Cd Length: 1290
Bit Score: 1480.81
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 24 R RLQ EKLPTLQ S VET E LCYNVHWA A E tl PW AEE MK KL MW L FG cplvr DDV A QEP wlvpg SNDL L LE V G PR LNFST P A S TN 103
Cdd:PRK05297 20 A RLQ AAVLPVT S IYA E YVHFADLS A P -- LS AEE QA KL ER L LT ----- YGP A EHE ----- PAGR L FL V T PR PGTIS P W S SK 87
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 104 IVSVCQAA GL RAVD R V E TTRR Y RLSFT dh PT AE ME A ISL A A LHDRMTE QHYP D PIQS --- FS PQS i P A PL K g S I D I L AE G 180
Cdd:PRK05297 88 ATDIAHNC GL AGIR R I E RGIA Y YVEAA -- LS AE QR A ALA A L LHDRMTE SVFA D LDDA eal FS HHE - P K PL T - S V D V L GG G 163
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 181 R P ALE K AN Q ELGLAL DSWDL D FYTKR F QE L Q RNP ST VE VFDL AQ S NSEH S RH WF F KGQLHV DG KKLAH SLF ES I MS T QAS 260
Cdd:PRK05297 164 R A ALE A AN V ELGLAL AEDEI D YLVEA F TK L G RNP TD VE LMMF AQ A NSEH C RH KI F NADWTI DG EEQPK SLF KM I KN T HET 243
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 261 s NP NN VL K - FC DN SSAIQ G K KV KFLR P EDS T rp SCFQQQ Q GLR H VVFTA ETHN F PT GVA PF S GA T TG T GG R IRD VQC TGR 339
Cdd:PRK05297 244 - NP DG VL S a YK DN AAVME G S KV GRFF P DPD T -- GRYGYH Q EPA H ILMKV ETHN H PT AIS PF P GA A TG S GG E IRD EGA TGR 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 340 G AHVV AG TA G YCFG NL H IP DYNL PWE DP s FQY P GNF A RP L EVA IE ASN G ASDYG N K FG E P V L A G FA R SLGLQLPDG -- QR 417
Cdd:PRK05297 321 G SKPK AG LT G FSVS NL R IP GFEQ PWE ED - YGK P ERI A SA L DIM IE GPL G GAAFN N E FG R P N L L G YF R TFEQKVNSH ne EV 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 418 R EWI KPIM FS GGIG SME A K HV G K KPPEP G MEVVKV GGP VY RIG V GGGAASS V q VQ G DNTS DLDF GA VQRG D PEME QKMNR 497
Cdd:PRK05297 400 R GYH KPIM LA GGIG NIR A D HV Q K GEIPV G AKLIVL GGP AM RIG L GGGAASS M - AS G QSSE DLDF AS VQRG N PEME RRCQE 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 498 VI RA C VEAPGG NPI C S L HD Q GAGG NG N VLK EL SDPE -- G AIIYTSRFQLGD P TLNA LEIW GA E Y QE SNA L LLR P S D RDFL 575
Cdd:PRK05297 479 VI DR C WQLGDD NPI L S I HD V GAGG LS N AFP EL VNDG gr G GRFDLRKIPNDE P GMSP LEIW CN E S QE RYV L AIA P E D LELF 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 576 SRASA RERCP ACF VG TI T GDKRIV L V D D reclvgktgqgdap LTPPT PVDL D LD WV LGK M P QKEFFLQRKPPVLQP L ALP 655
Cdd:PRK05297 559 EAICE RERCP FAV VG EA T EERHLT L E D S -------------- HFDNK PVDL P LD VL LGK P P KMHRDVKTVKAKGPA L DYS 624
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 656 p ELSVRQ A LN RVLRLP A VASK RY L TNKV DRSV G GLVA QQ Q C VGP L Q T P L AD V AV V A L S HQECI G A A T A L GE QPVKS LLD P 735
Cdd:PRK05297 625 - GIDLAE A VE RVLRLP T VASK SF L ITIG DRSV T GLVA RD Q M VGP W Q V P V AD C AV T A A S YDGYA G E A M A M GE RTPVA LLD A 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 736 K A A AR L AV S EALTN LVF A LVT DL RDV K C S G NWM W AA KL PGE G A A L A DA CE A MVAVMA - ALG VAVDG GKDSLSM AARV --- 811
Cdd:PRK05297 704 A A S AR M AV G EALTN IAA A PIG DL KRI K L S A NWM A AA GH PGE D A R L Y DA VK A VGMELC p ALG ITIPV GKDSLSM KTKW qeg 783
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 812 - GTET V QA P G SL V ISA Y A VCP D ITA T V TP D L KHPGG k GH LL YVP L SP G QH RLGG T ALAQ CFS QLG EHP PD L D LP E N L VRA 890
Cdd:PRK05297 784 g EDKE V TS P L SL I ISA F A PVE D VRK T L TP Q L RTDKD - TA LL LID L GR G KN RLGG S ALAQ VYN QLG DKA PD V D DA E D L KGF 862
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 891 F HIT Q G L LK E CR L CSG HD V SDGGL V T C L L EMAFAG N CG IEV D VP A P G IH AL PV LF A EE P G L V LE V QE AD VAG V RQRYESA 970
Cdd:PRK05297 863 F NAI Q A L VA E GL L LAY HD R SDGGL L T T L A EMAFAG H CG LDI D LD A L G DD AL AA LF N EE L G A V IQ V RA AD RDA V EAILAEH 942
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 971 GL - R C L elg H T - G EAGPQAMAR I SV N KAV V VE E PVG ELR AL W E ETS F Q LDL L QAE P R C VIE E KQGLKERTG P SYYLPP TF 1048
Cdd:PRK05297 943 GL s D C V --- H V i G KPNAGDRIV I TR N GKT V FS E SRT ELR RW W S ETS Y Q MQR L RDN P E C ADQ E FDAILDQAD P GLNVKL TF 1019
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1049 PVA --- SV P CKPG G PV P R VAILRE E G S N GDR EMA D AF HL AGF EVW DV T M Q DL CS G AIR L DT F R G VAFV GGFSY A DVLG SA 1125
Cdd:PRK05297 1020 DPN edi AA P FIAT G AR P K VAILRE Q G V N SHV EMA A AF DR AGF DAI DV H M S DL LA G RVT L ED F K G LVAC GGFSY G DVLG AG 1099
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1126 K GWA AAVT FNP QA R EELGR F RR RPDTF S LGVCNGCQ LLAL L GWVG sdpseeqae PG QDSQ P T qpgll LRH N L S GR FE S R W 1205
Cdd:PRK05297 1100 E GWA KSIL FNP RL R DQFEA F FA RPDTF A LGVCNGCQ MMSN L KEII --------- PG AEHW P R ----- FVR N R S EQ FE A R F 1165
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1206 AT V R V EPG P ALM L R GM E GS V LP VWS AHGEG YMA F SSPE L Q A k I EAKGLV P L HWA D DD G NP TE Q YP L NPNGSP G GI A G ICS 1285
Cdd:PRK05297 1166 SL V E V QES P SIF L Q GM A GS R LP IAV AHGEG RAE F PDAH L A A - L EAKGLV A L RYV D NH G QV TE T YP A NPNGSP N GI T G LTT 1244
1290 1300 1310 1320
....*....|....*....|....*....|....*....|....*.
gi 226958458 1286 Q DGR HLAL MPHPER AV R LW Q WA W R P S pf DVLPT SPW LQL F I NAR N W 1331
Cdd:PRK05297 1245 A DGR VTIM MPHPER VF R TV Q NS W H P E -- EWGED SPW MRM F R NAR K W 1288
PurL1
COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and ...
177-1013
0e+00
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439816 [Multi-domain]
Cd Length: 747
Bit Score: 669.06
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 177 L AE GR P ALE K AN Q ELGLAL DSWDL D FYTKR fqe L Q RNP ST VE VFDLA Q SN SEH SRHWFFKGQ L hvdg K K L A hslfesims 256
Cdd:COG0046 6 L EG GR E ALE E AN R ELGLAL SDDEY D YIVEI --- L G RNP TD VE LGMFS Q MW SEH CSYKSSNAL L ---- K S L P --------- 69
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 257 tqa SSN P NNVLKFC DN SSAIQGK kvkflrp EDS trpscfqqqqglr H VVF TA E T HN F P TGVA P FS GA T TG T GG R IRD VQ c 336
Cdd:COG0046 70 --- TEG P RVLSGPG DN AGVVDIG ------- DGL ------------- A VVF KV E S HN H P SAIE P YQ GA A TG V GG I IRD IF - 125
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 337 t G R GA HVV AG TAGYC FGNL HI P D ynlpwedpsfqypgnf A R P LEVA I EASN G AS DYGN K FG E P VLA G FA R S lglqlp D GQ 416
Cdd:COG0046 126 - G M GA RPI AG LDSLR FGNL DQ P P ---------------- A S P RYIL I GVVA G IA DYGN C FG V P TVG G EV R F ------ D ES 182
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 417 RRE wi K P IMFS GG I G SME A K H VG K - K P P EP G ME VV K VGGP VY R I G V GG GAAS S V q VQ G DN t S D LD FG AVQ R GDP E ME QKM 495
Cdd:COG0046 183 YEG -- N P LVNA GG V G IIR A D H IF K a K A P GV G NK VV Y VGGP TG R D G I GG ATFA S E - EL G ED - S E LD RP AVQ V GDP F ME KRL 258
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 496 NRV I RACVEA pgg NP I CSLH D Q GAGG NGNVLK E LSD -- PE GA I I YTSRFQ L GD P TLNAL EIW GA E Y QE SNA L LLR P SDRD 573
Cdd:COG0046 259 IEA I LELGDT --- GL I VGIQ D M GAGG LSSASS E MAA kg GL GA E I DLDKVP L RE P GMSPY EIW LS E S QE RML L VVK P EKLE 335
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 574 FLSRASA R E R C PA CFV G TI T G D K R I V LV D DR E clvgktgqgdapltpp T PV DL D LD WVL G KM P QKEFFLQ R k P PV L Q PL A 653
Cdd:COG0046 336 EFEAIFE R W R L PA AVI G EV T D D G R L V VT D HG E ---------------- T VA DL P LD FLA G GA P KYHRPAK R - P AY L E PL D 398
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 654 LP PELSVRQ AL N R V L RL P A VASK RY L TNKV DR S VGG LVAQQQ cvgplqt PL AD V AVV ALSHQE c I G A A TAL GE Q P VKS LL 733
Cdd:COG0046 399 LP EPIDLEE AL L R L L SS P N VASK EW L YRQY DR E VGG NTVRDP ------- GV AD A AVV RVDGTY - K G L A MST GE N P RYA LL 470
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 734 DP K A A AR L AV S EA LT NL VFALVTD L r DVKCSG NW MWAA K l P G E G A A L AD A CEAMVAVMA ALG VA V DG G KD SL SMAARV G t 813
Cdd:COG0046 471 DP Y A G AR M AV A EA AR NL AAVGAEP L - AITDCL NW GNPE K - P E E M A Q L VE A VKGLADACR ALG IP V PS G NV SL YNETKD G - 547
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 814 e T V QA P GSL VI S A YAVCP D ITA TVTPDLK HP ggk G H LLY V p LSPGQHR LGG TAL AQ CFS QLG EH PPD L D l P E NLVRA F HI 893
Cdd:COG0046 548 - K V AI P PTP VI G A VGLVD D VRK TVTPDLK KE --- G D LLY L - IGETKNE LGG SEY AQ VLG QLG GE PPD V D - L E AEKAL F EA 621
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 894 T Q G L LK E CRLCSG HDVSDGGL VTC L L EMAFAG NC G IEV D VP A - PGIHALPV LF A E EP G - L V LE V QEA D VAG V RQRYES AG 971
Cdd:COG0046 622 V Q E L IR E GLILAA HDVSDGGL AVA L A EMAFAG GL G ADI D LD A l GDLRPDAA LF S E SQ G r A V VQ V APE D AEA V EALLAE AG 701
810 820 830 840
....*....|....*....|....*....|....*....|..
gi 226958458 972 L RCLEL G HTGEAG pqa MAR I SVNKAVVVEEPVG ELR AL WEET 1013
Cdd:COG0046 702 L PAHVI G TVTGDD --- RLV I RRGGETLLSLSLA ELR DA WEET 740
PHA03366
PHA03366 FGAM-synthase; Provisional
526-1332
4.88e-140
FGAM-synthase; Provisional
Pssm-ID: 223058 [Multi-domain]
Cd Length: 1304
Bit Score: 461.03
E-value: 4.88e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 526 L KE L SD P E G AIIYT S R fq L GDPTLNA L EIWG A EYQ E S N -------------- ALL L RPSDR ---------- D F L S RA SAR 581
Cdd:PHA03366 439 L LA L CP P G G LLLFL S A -- L PEDVVSG L KPFS A SNR E T N eeivkqyflnvycs VVF L VIKNT heggegvtpl D A L K RA CRL 516
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 582 ER CP ACFV G TITGDKR I VL V D D RECL V G k TGQG D APLT P PT P VDLDLDWVLGKMP qkeff LQRKP P VL Q PLALP - PELSV 660
Cdd:PHA03366 517 AG CP VHIL G RTVPLPG I HF V N D LGNP V Y - GELR D DQFK P TF P LQPSRPLSPVSAT ----- SEDTR P SP Q DESID w ALFNL 590
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 661 RQA L NRV L RL P A V A SK R Y LTNKV DR SVG G L VAQQ QC VGPL QT P LA D VAV V AL S HQE ------------------------ 716
Cdd:PHA03366 591 NST L LQI L SH P T V G SK E Y IVRHI DR CGN G R VAQQ PG VGPL DL P VS D YSI V VH S SVK trraietpsstedltyqeadelin 670
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 717 ----------------- CI G AAT ALGEQ PV K SL LDP KAA A RL A VS EALTNL VF A L V TD L R D VKCSGNWM W A akl P GEG AA 779
Cdd:PHA03366 671 spltwfdpddesvlhpa VP G TCS ALGEQ GY K VQ LDP ILG A KY A IV EALTNL ML A P V AN L E D ITITLSVT W P --- P TDQ AA 747
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 780 ----- LAD AC EAMVA vma A LGV AV dggkd SLSM A ARVGTETVQAPG ----- SL V IS A Y A VC P DI T ATV TPDLK H PG G kg H 849
Cdd:PHA03366 748 selyr ALA AC KEFCR --- E LGV NF ----- TFTS A SSSPRQDQPPQP gplfn TI V FT A S A PV P SS T PRL TPDLK K PG S -- A 817
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 850 L LYVPL SP GQH r L G G TALA Q C F SQLGEHP PD LD l P EN L VRA F HIT Q G L LK E CRLC SGHDVSDGGL VT CL L EMA F AG NC G I 929
Cdd:PHA03366 818 L VHLSI SP EYT - L A G SVFE Q I F GLKSGTL PD IS - P SY L KNL F RAV Q H L IS E GLVV SGHDVSDGGL IA CL A EMA L AG GR G V 895
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 930 EVD VPA p G IHA L PV LF A E E PG L V L EV QEADVAG V RQ R YE S AGLR C LEL G HT G EA GP QAMARI S V N KA V VVE E PVGE LR AL 1009
Cdd:PHA03366 896 TIT VPA - G EDP L QF LF S E T PG V V I EV PPSHLSA V LT R LR S RNII C YPI G TV G PS GP SNTFSV S H N GT V LFR E SLSS LR ST 974
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1010 W ee T SF QLDLLQAEPRCVI EE KQGL K ERTGPSYY L P P ------ T F P VASV -- P C K P ggpv P RVA I L REE G SN G DREMAD A 1081
Cdd:PHA03366 975 W -- R SF SDEQFELLRPDLT EE SMYR K DYGNNEVD L G P leeglt T S P LRLY tc P D K R ---- H RVA V L LLP G CP G PHALLA A 1048
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1082 F HL AGF EVWD V TMQD L CS G AI r LD T F R G VAFV G GFSYA D VLGS A KGWA AA VTF NP QA R EE L G RF RR RPDTFSLG VCN - GC 1160
Cdd:PHA03366 1049 F TN AGF DPYP V SIEE L KD G TF - LD E F S G LVIG G SSGAE D SYTG A RAAV AA LLS NP AV R DA L L RF LN RPDTFSLG CGE l GC 1127
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1161 Q L L AL L GW VGS DPSEEQ ae PG QDSQPTQ P GL L LR h N L SG RF ESRW ATVRV - E PGPALM LR GME GSVLP V W s A H G E g YMA F 1239
Cdd:PHA03366 1128 Q I L FA L KA VGS TAPSPV -- PG TETEEQW P IT L EP - N A SG LY ESRW LNFYI p E TTKSVA LR PLR GSVLP C W - A Q G T - HLG F 1202
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1240 S -- SPELQAKIEAK G LVPLHWAD --- D D GNP TEQ YP L NP N G S p GGI AG I CS Q DGRHLAL MPH P ERAVRL WQW AWR P SPFD 1314
Cdd:PHA03366 1203 R yp NDGMEYILRNS G QIAATFHG adv D P GNP ARH YP R NP T G N - SNV AG L CS A DGRHLAL LFD P SLSFHP WQW QHV P PENG 1281
890
....*....|....*...
gi 226958458 1315 V L PT SPW LQL F INARN W T 1332
Cdd:PHA03366 1282 P L KV SPW KLM F QDLHL W C 1299
GATase_5
pfam13507 CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not ...
1062-1331
4.94e-140
CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not found in pfam00310, pfam07685 and pfam13230.
Pssm-ID: 463904 [Multi-domain]
Cd Length: 260
Bit Score: 427.30
E-value: 4.94e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1062 PRVAILRE E G S NG DR EMA D AF HL AGF EVW DV T M Q DL C SG AIR LD T F R G V A FV GGFSY A DVLGS A KGWAA AVT FNP QA R EE 1141
Cdd:pfam13507 2 PRVAILRE P G T NG EY EMA A AF ER AGF DAV DV H M S DL L SG RVS LD D F Q G L A AP GGFSY G DVLGS G KGWAA SIL FNP KL R DA 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1142 LGR F RR RPDTFSLG V CNGCQLL AL LG WV gsdpseeqae PG QDSQPTQPGLL L RH N L SGRFESRW AT V RV - E PG P ALM LRG 1220
Cdd:pfam13507 82 FEA F FN RPDTFSLG I CNGCQLL SK LG LI ---------- PG GEGDLAERWPT L TR N D SGRFESRW VN V KI s E KS P SVF LRG 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1221 M E GS V LPV ws AHGEG YMA F S S P E LQ A KI EA K G L V P L HWA D DD GNPTE Q YP L NPNGSP G GIAGICS Q DGR H L A LMPHPER A 1300
Cdd:pfam13507 152 M D GS G LPV -- AHGEG RFV F R S E E VL A RL EA N G Q V A L RYV D NA GNPTE E YP F NPNGSP L GIAGICS P DGR V L G LMPHPER V 229
250 260 270
....*....|....*....|....*....|.
gi 226958458 1301 V R L WQW AWR P s P FDVLPT SPWL Q LF I NAR N W 1331
Cdd:pfam13507 230 F R P WQW PHW P - P GEWEEV SPWL R LF R NAR K W 259
PurL_repeat1
cd02203 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. ...
218-608
2.88e-123
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100034 [Multi-domain]
Cd Length: 313
Bit Score: 384.52
E-value: 2.88e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 218 E VFDL AQ SN SEH S RH WF FK gqlhvdgkklah SL FES I M stqassnpnnvlkfcdnssaiqgkkvkflrpedstrpscfqq 297
Cdd:cd02203 1 E LGMF AQ MW SEH C RH KS FK ------------ SL LKM I W ------------------------------------------ 26
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 298 qqglr H VVF TA ETHN F P TGVA PF S GA T TG T GG R IRD VQCT G rg A HVV A GTA G YC FG N L H IP D Y nlpwedpsfq Y P GNFAR 377
Cdd:cd02203 27 ----- A VVF KV ETHN H P SAIE PF G GA A TG V GG I IRD ILSM G -- A RPI A LLD G LR FG D L D IP G Y ---------- E P KGKLS 89
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 378 P LEVAIEASN G A SDYGN KF G E P VLA G FA R S lglqlp D GQR re WIK P IMFS G GI G SMEAK H VG K - K P P E PG ME VV K VGG PV 456
Cdd:cd02203 90 P RRILDGVVA G I SDYGN CI G I P TVG G EV R F ------ D PSY -- YGN P LVNV G CV G IVPKD H IV K s K A P G PG DL VV L VGG RT 161
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 457 Y R I G V GG GAA SS VQV q GD N T S D LD FG AVQ R GDP E ME Q K MNRV I RACV E A pgg NP I CSLH D Q GAGG NGNVLK E LSD -- PE G 534
Cdd:cd02203 162 G R D G I GG ATF SS KEL - SE N S S E LD RP AVQ V GDP F ME K K LQEA I LEAR E T --- GL I VGIQ D L GAGG LSSAVS E MAA kg GL G 237
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226958458 535 A I I YTSRFQ L GD P TLNAL EIW GA E Y QE SNA L LLR P S D RDFLSRASAR E RCP A CFV G TI T G D K R IV L VDDR E CLV 608
Cdd:cd02203 238 A E I DLDKVP L RE P GMSPW EIW IS E S QE RML L VVP P E D LEEFLAICKK E DLE A AVI G EV T D D G R LR L YYKG E VVA 311
tegu_FGAM_synt
TIGR01739 herpesvirus tegument protein/v-FGAM-synthase; This model describes a family of large proteins ...
397-1332
2.41e-119
herpesvirus tegument protein/v-FGAM-synthase; This model describes a family of large proteins of herpesvirues. The protein is described variably as tegument protein or phosphoribosylformylglycinamidine synthase (FGAM-synthase). Most of the length of the protein shows homology to eukaryotic FGAM-synthase. Functional characterizations were not verified during construction of this model.
Pssm-ID: 273784 [Multi-domain]
Cd Length: 1202
Bit Score: 401.76
E-value: 2.41e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 397 G E P VLA GF A R --- SLG L Q LP DGQR rewik P IMFSGGIGSMEAKHVGKKPPE PG MEV V KV G -- G P VYR igvgggaa SSVQV 471
Cdd:TIGR01739 237 G V P TCG GF I R lis KNK L S LP TPYT ----- P TYNTSILDRLCHVTINTADEP PG QDI V AL G qf E P SLL -------- PDTPP 303
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 472 QGDNT S D LD FGAVQ rgdpeme QKMNRVIR acv EAPGGNPIC S LHDQ G AGGNGNV L KE L SD P E GA IIYT S rf Q L G D PTLN A 551
Cdd:TIGR01739 304 LLYAD S P LD VNKIL ------- TALALLTD --- DVKTPCIVG S IRPL G PCSVKEH L TA L LP P C GA ELDL S -- N L P D EVVA A 371
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 552 L EIWGAEYQES N ALLLR ---------------------------- P SD R df L SR A SARER CP ACFV G TITGDKRIVL V D D 603
Cdd:TIGR01739 372 L ARSSPANRVE N EKMVK qyflnvvcsvvfltvkntphntgtegvt P LE R -- L KT A CRMFG CP VKVL G KLVPLPGLHI V S D 449
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 604 rec L VGK tgqgdaplt P PT PVDL D LDWVLGKM P qk EFF L QRKP PV -- LQ P LA L PPE ----- L SV R QALNRV L RL P A V A SK 676
Cdd:TIGR01739 450 --- L FNP --------- V PT YPTF D FTSFTPTS P -- LLP L GGPE PV sr TR P MF L DES lnwqt L NL R STILKI L SH P T V G SK 515
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 677 RYLTNKV DR SVG G L VAQQQ C VGPL QT P LA D VAV V ALSHQE ------------------------------------ CIGA 720
Cdd:TIGR01739 516 EFIVRHI DR CGN G R VAQQQ G VGPL DL P VS D YSL V LHNLSR ptdttevtysenamdlildpdswlyswenevlenpa LSCV 595
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 721 AT ALGEQ PV K SLL DPK AA A RL A VS EAL T NL VFALVTD L R DV KCSGNWM W AAKLP g EGAA L A DA CE A MVAVMAA LGV AV dg 800
Cdd:TIGR01739 596 CS ALGEQ TY K VQA DPK RG A TY A IT EAL L NL SLSPWNT L E DV IITLSVT W SPTDH - VYSL L K DA LR A CKDFCEE LGV SF -- 672
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 801 gkd SLSM AA RVG T E - TVQ AP - G S L V I SA YAVCPDITATV TPDLK HP G G kg HL LYVP L S P g QHR L G G TALA Q CFSQLGEHP 878
Cdd:TIGR01739 673 --- TVTS AA SSP T Q d SGS AP f M S I V F SA SCPVLLSAKKI TPDLK SH G S -- HL IWLS L H P - SYT L A G SIFE Q ILGLSFIRL 746
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 879 P D L D l P EN L VRAFHIT Q G L L KE CRLC SGHDVSDGGLV T C LL EMA FA G NC G IEVDV P A p G IHA L PV L FA E E PG L V L EV QEA 958
Cdd:TIGR01739 747 P A L S - P VS L KKLLSAL Q T L V KE GVIV SGHDVSDGGLV A C VA EMA LS G GK G VRITL P H - G TDP L EF L CS E T PG V V I EV DPS 824
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 959 DVAG V R Q RYE S A GL RCLEL G HT GE A GP QAMARISV N KA V VVE EP VGE L RAL W EET S FQLDL L QAEPR cvi E EKQGLKERT 1038
Cdd:TIGR01739 825 SMYA V L Q FLR S E GL VFQVI G RV GE S GP SPTFSVVH N ST V LFQ EP LSL L QGT W RSF S DEENT L LCPNL --- E PREMHVLDY 901
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1039 G P -- SYYLP ----- P TF P VASVP C KP gg P VPR VA I L REE G SNGDREMAD A FHL AGF EVWD V TMQD L CSGAI r LDTF R G VA 1111
Cdd:TIGR01739 902 G Y ne MDFGG vpkgl P LS P LRFFT C PD -- P RHQ VA V L LLP G QSVPHGLLA A LTN AGF DPRI V SITE L KKTDF - LDTF S G LI 978
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1112 FV G GFSYA D VLGS A KGW AAA VTF N PQAREE L GR F RR RPDTFSLG VCN - GCQLL AL L GW VG SDP S eeqae PGQDSQ PT QP - 1189
Cdd:TIGR01739 979 IG G ASGTL D SEVG A RAL AAA LLR N QAFLRD L LT F LN RPDTFSLG FGE l GCQLL LA L NI VG YTQ S ----- SPFITV PT EV q 1053
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1190 - GLL L RH N L SG RF ESRW ATVRV - E PGPALM LR GME GSVLP V W s A H G E g YMAF -- SSPELQAKI E AK G LVPLHWAD --- DD 1262
Cdd:TIGR01739 1054 e PPR L EK N A SG LY ESRW LNFYI p E TTKSVF LR PLR GSVLP C W - A Q G T - HLGL yh PDDGVEEEL E NS G QIASTFHG nsp SS 1131
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1263 G N P TEQ YP L NP N G S p GGI AG I CS Q DGRHLAL MPH P ERAVRL WQW AWR P SPFDV L PT SPW LQL F INARN W T 1332
Cdd:TIGR01739 1132 G L P ATN YP R NP S G G - SNV AG L CS A DGRHLAL LID P SLSFFP WQW QHV P PNNPP L QV SPW KLM F QRLHL W S 1200
GATase1_FGAR_AT
cd01740 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ...
1064-1329
8.70e-101
Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT). FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway. FGAR-AT is a glutamine amidotransferase. Glutamine amidotransferase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. FGAR-AT belongs to the triad family of amidotransferases having a conserved Cys-His-Glu catalytic triad in the glutaminase active site
Pssm-ID: 153211 [Multi-domain]
Cd Length: 238
Bit Score: 320.72
E-value: 8.70e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1064 VA I LR EE GSN G DR E MA D AF H LAGFE VW DV TMQ DL CS G AIR LD TFR GV AFV GGFSY A D V L GSAKGW AA A vtfn P QAR EE LG 1143
Cdd:cd01740 1 VA V LR FP GSN C DR D MA Y AF E LAGFE AE DV WHN DL LA G RKD LD DYD GV VLP GGFSY G D Y L RAGAIA AA S ---- P LLM EE VK 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1144 R F RR R p DTFS LG V CNG C Q L L AL LG WV gsdpseeqaepgqdsqptq PG L L L R h N LSGR F ---- ES R WA T V RVE PGPALMLR 1219
Cdd:cd01740 77 E F AE R - GGLV LG I CNG F Q I L VE LG LL ------------------- PG A L I R - N KGLK F icrw QN R FV T L RVE NNDSPFTK 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1220 G - MEG S VL PVWS AHGEG YMAFSSPE L QAKI E AKGLV pl HWA DDDGN P TE Q YP L NPNGS PG GIAGIC SQ DGR H L AL MPHPE 1298
Cdd:cd01740 136 G y MEG E VL RIPV AHGEG RFYADDET L AELE E NGQIA -- QYV DDDGN V TE R YP A NPNGS LD GIAGIC NE DGR V L GM MPHPE 213
250 260 270
....*....|....*....|....*....|.
gi 226958458 1299 RAV RL WQW awrpsp FDV L PT S PW L Q LF I NA R 1329
Cdd:cd01740 214 RAV EP WQW ------ ERL L GG S DG L K LF R NA V 238
PurL2
COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain ...
1062-1331
2.65e-84
Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439817 [Multi-domain]
Cd Length: 236
Bit Score: 275.01
E-value: 2.65e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1062 P R VAIL REE GSN G DR E MA D AF HL AG F E VW DV TMQ DL csg AIR LD T F R G VAFV GGFSY A D V L GSAKGW A AA vtfnp QAREE 1141
Cdd:COG0047 1 P K VAIL VFP GSN C DR D MA A AF ER AG A E AE DV WHS DL --- RTD LD D F D G LVLP GGFSY G D Y L RAGAIA A FS ----- PIMDA 72
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1142 LGR F R RR p DTFS LG V CNG C Q L L AL LG WV gsdpseeqae PG Q ds Q P T qpgll L RH N L S G RF ES RW ATV RVE PGPALMLR GM 1221
Cdd:COG0047 73 VRE F A RR - GGLV LG I CNG F Q I L TE LG LL ---------- PG I -- W P A ----- L TR N R S L RF IC RW VYL RVE NNDSPFTS GM 134
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1222 E - G S V L P VWS AHGEG Y m AFSSP E LQ A KI EA K G L V PLHWA D D DGN P T eq YP L NPNGS PGG IAGI CSQ DG RH L AL MPHPERA 1300
Cdd:COG0047 135 E a G E V I P IPI AHGEG R - YVADE E TL A EL EA N G Q V AFRYV D A DGN V T -- YP A NPNGS LNN IAGI TNE DG NV L GM MPHPERA 211
250 260 270
....*....|....*....|....*....|.
gi 226958458 1301 V RLWQ waw R P S pfdvl PTSPW L QL F IN A RNW 1331
Cdd:COG0047 212 V EPLL --- G P G ----- ESTDG L RI F RS A VKY 234
PurL_repeat2
cd02204 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. ...
706-980
7.63e-79
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100035 [Multi-domain]
Cd Length: 264
Bit Score: 260.93
E-value: 7.63e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 706 D V AV VALSHQECI G A A TAL GE Q P VK SLLDP K A A A R LAV S EA LT NLV FALVTD L r DVKCSG N WMWAA K LP GE GAA L AD A CE 785
Cdd:cd02204 1 D A AV LRIPGETDK G L A MST GE N P RY SLLDP Y A G A A LAV A EA VR NLV AVGADP L - AITDCL N FGNPE K PE GE MGQ L VE A VL 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 786 AMVAVMA ALG VA V D GGKDSL SMA arvg TE T V QA P GS LVI S A YA V CP D ITAT VT P D L K HP G GK gh L LYVPLSPGQHRLGGT 865
Cdd:cd02204 80 GLGDACR ALG TP V I GGKDSL YNE ---- TE G V AI P PT LVI G A VG V VD D VRKI VT L D F K KE G DL -- L YLIGETKDELGGSEY 153
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 866 ALA qc FSQ LG EHP P D L DLP E NLVRA F HIT Q G L L KE CRLC S G HDVSDGGL VTC L L EMAFAG NC G I EVD VPAPG i HALPV LF 945
Cdd:cd02204 154 ALA -- YHG LG GGA P P L VDL E REKAL F DAV Q E L I KE GLVL S A HDVSDGGL AVA L A EMAFAG GL G A EVD LSKDD - AEDEL LF 230
250 260 270
....*....|....*....|....*....|....*
gi 226958458 946 A E EP G L VL EVQEADVAG V R q RY E S AG LRCLEL G HT 980
Cdd:cd02204 231 S E SL G R VL VEVKPENEE V F - EA E E AG VPATVI G TV 264
FGAM_synth_II
TIGR01736 phosphoribosylformylglycinamidine synthase II; Phosphoribosylformylglycinamidine synthase is a ...
304-1012
6.99e-60
phosphoribosylformylglycinamidine synthase II; Phosphoribosylformylglycinamidine synthase is a single, long polypeptide in most Proteobacteria and eukarotes. Three proteins are required in Bacillus subtilis and many other species. This is the longest of the three and is designated PurL, phosphoribosylformylglycinamidine synthase II, or FGAM synthase II. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273781 [Multi-domain]
Cd Length: 715
Bit Score: 220.25
E-value: 6.99e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 304 VVF TA E T HN F P TGVA P FS GA T TG T GG RI RD VQCT gr GA HVV A GTAGYC FG N L HI P dynlpwedpsfqypgnfa RPLEVAI 383
Cdd:TIGR01736 71 VVF KM E S HN H P SAIE P YN GA A TG V GG IL RD ILSM -- GA RPI A LLDSLR FG P L DD P ------------------ KNRYLFE 130
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 384 EASN G A SDYGN KF G E P VLA G --- F AR S L glqlp D G Q rrewik P IMFSGGI G SMEAKHVGK - K PPE PG MEV V K VGG PVY R I 459
Cdd:TIGR01736 131 GVVA G I SDYGN RI G V P TVG G eve F DE S Y ----- N G N ------ P LVNVMCV G LVRKDDIVT g K AKG PG NKL V L VGG KTG R D 199
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 460 G V GG GAAS S VQV q GDNTSDL D FG AVQ R GDP EM E QKM nrv I R A CV EA PGGNPICSLH D Q GA G G NGNVLK E LSDPE -- GA I I 537
Cdd:TIGR01736 200 G I GG ATFA S EEL - SEEAEEE D RP AVQ V GDP FT E KLL --- I E A TL EA VDTGLVKGIK D L GA A G LTSASS E MAAKG gl GA E I 275
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 538 Y TSRFQ L GD P TLNAL EI WGA E Y QE SNA L LLR P S D RDFLSRASARERC PA CFV G TI T GDK RI V L VDDR E CLV gktgqg D A P 617
Cdd:TIGR01736 276 Y LDKVP L RE P GMTPY EI MLS E S QE RML L VVA P E D VEEVLEIFEKYEL PA SVI G EV T DEG RI R L YYKG E VVA ------ D L P 349
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 618 LTPPT -- P V dld LDW vlgkm P QKE fflq R K P P VLQPLAL PP E l SVRQ A LNR VL RL P AV ASK RYLTNKV D RS V GG lvaqqq 695
Cdd:TIGR01736 350 IELLA da P E --- YER ----- P SEP ---- P K Y P EEEKEPE PP A - DLED A FLK VL SS P NI ASK EWVYRQY D HE V QT ------ 410
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 696 cv GPLQT P LA D V AV VALSHQECI G A A TALGEQ P VKSL LDP K A A A RL AV S EA LT NL VFALVTD L RD V K C -- S GN ------- 766
Cdd:TIGR01736 411 -- RTVVK P GE D A AV LRIKETGKL G L A LTADCN P RYVY LDP Y A G A AG AV A EA YR NL AAVGAEP L AA V D C ln F GN perpevy 488
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 767 W MWAAKLP G egaa L A DAC E amvavma ALG VA V D GG KD SL SMA arvg T ET V QAPGSLV I SAYAVCP D ITATV T PDL K hpg G 846
Cdd:TIGR01736 489 W QFVEAVK G ---- L G DAC R ------- ALG TP V V GG NV SL YNE ---- T NG V PIAPTPT I GMVGLVE D VEKLL T SNF K --- K 550
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 847 K G HLL Y V pls P G QHR -- LGG TALAQCFSQLGEH - P P DL DL p E NLVRAFHITQGLLKECRLCSG HDVS D GGL VTC L L EMA F 923
Cdd:TIGR01736 551 E G DAI Y L --- I G ETK de LGG SEYLRVIHGIVSG q V P AV DL - E EEKELADAVREAIRAGLVSAA HDVS R GGL AVA L A EMA A 626
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 924 A GNC G I EVD VPA - PGIHALPV LF A E EP G - LVLE V Q E ADVAGVR qry E S A G LRCLEL G H TG ea G P qama R ISV - NKAVVVE 1000
Cdd:TIGR01736 627 A SGI G A EVD IDE i ASARPDEL LF S E SN G r AIVA V P E EKAEEAV --- K S K G VPAKVI G K TG -- G D ---- R LTI k TGDDTIS 697
730
....*....|..
gi 226958458 1001 EP V G ELR AL WEE 1012
Cdd:TIGR01736 698 VS V K ELR DA WEE 709
PRK01213
PRK01213 phosphoribosylformylglycinamidine synthase subunit PurL;
304-1013
7.12e-52
phosphoribosylformylglycinamidine synthase subunit PurL;
Pssm-ID: 234921 [Multi-domain]
Cd Length: 724
Bit Score: 196.09
E-value: 7.12e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 304 VVF TA E T HN F P TG V A P FS GA T TG T GG RI RD VQCT G rg A HVV A GTAGYC FG N L hipdynlpw ED P SFQ Y -- P G nfarpl E V 381
Cdd:PRK01213 83 VVF KI E S HN H P SA V E P YQ GA A TG V GG IL RD IFSM G -- A RPI A LLDSLR FG E L --------- DH P KTR Y ll E G ------ V V 145
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 382 A ieasn G ASD YGN KF G E P VLA G --- F AR S L glqlp D G Q rrewik P IMFSGGI G SMEAKHVGK - K PPEP G ME VV K VG GPVY 457
Cdd:PRK01213 146 A ----- G IGG YGN CI G V P TVG G evy F DE S Y ----- N G N ------ P LVNAMCV G LVRHDDIVL a K ASGV G NP VV Y VG AKTG 209
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 458 R I G V GG GAAS S VQVQGDNTSDL df G AVQ R GDP E ME Q kmn RV I R AC V E APGGNPICSLH D Q GA G G ---------- N G NV lk 527
Cdd:PRK01213 210 R D G I GG ASFA S AELSEESEEKR -- P AVQ V GDP F ME K --- LL I E AC L E LIKTGLVVGIQ D M GA A G ltcsssemaa K G GL -- 282
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 528 elsdpe G AIIYTSRFQ L GDPTLNAL EI WGA E Y QE SNA L LLR P SDRD flsra SARERC ----- P A CFV G TI T G D K R IVLVD 602
Cdd:PRK01213 283 ------ G IELDLDKVP L REEGMTPY EI MLS E S QE RML L VVK P GKEE ----- EVLAIF ekwdl D A AVI G EV T D D G R LRVYH 351
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 603 DR E CLV gktgqg D A P --- L TPPT PV dld L D W vlgkm P Q KE fflqrk P PV L QP L ALP PE l SVRQ AL NRV L RL P AV ASK RYL 679
Cdd:PRK01213 352 HG E VVA ------ D V P aea L ADEA PV --- Y D R ----- P Y KE ------ P AY L DE L QAD PE - DLKE AL LKL L SS P NI ASK EWV 410
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 680 TNKV D RS V GG -- L V A qqqcvgplqt P LA D V AV VAL s HQECI G A A TALGEQ P VKSL LDP KAA A R LAV S EA LT NL V falvtd 757
Cdd:PRK01213 411 YEQY D HE V QT nt V V K ---------- P GG D A AV LRI - RGGGK G L A LTTDCN P RYVY LDP YEG A K LAV A EA AR NL A ------ 473
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 758 lrdvk CS G ---------- N W -------- MW A aklpgegaa LAD A CEAMVAVMA ALG VA V D GG KD SL S maarvg T ET VQAP 819
Cdd:PRK01213 474 ----- AV G atplaitdcl N F gnpekpev MW Q --------- FVE A VRGLADACR ALG TP V V GG NV SL Y ------ N ET GGTA 533
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 820 -- GSL VI SAYAVCP D ITATV T PDL K HP G gkg H L L Y V p L SPGQHR LGG TALAQCF - SQL G EH PP DL DL PE ----- N LVR A f 891
Cdd:PRK01213 534 iy PTP VI GMVGLID D VSKRT T SGF K KE G --- D L I Y L - L GETKDE LGG SEYLKVI h GHV G GR PP KV DL EA ekrlq E LVR E - 608
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 892 H I TQ GL LKEC rlcsg HDVS D GGL VTC L L EMA F AG NC G I EVD VPA p G IHALPV LF A E EP G - L V LE V QEADVAGVRQRY E S A 970
Cdd:PRK01213 609 A I RE GL VTSA ----- HDVS E GGL AVA L A EMA I AG GL G A EVD LSD - G LRPDAL LF S E SQ G r Y V VS V PPENEEAFEALA E A A 682
730 740 750 760
....*....|....*....|....*....|....*....|...
gi 226958458 971 G LRCLEL G HT G E agpqam ARIS V N ka VVVE E PVG ELR AL WE ET 1013
Cdd:PRK01213 683 G VPATRI G VV G G ------ DALK V K -- GNDT E SLE ELR EA WE GA 717
PurL
cd02193 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent ...
303-590
9.45e-41
Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100029 [Multi-domain]
Cd Length: 272
Bit Score: 152.07
E-value: 9.45e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 303 HVVFTA E T HN F P TGVA P FS GA T TG T GG R IRD VQC TG RG A HVV A GT A GYCFGNL H IPD ynlpwedpsfqypgnfarp LEVA 382
Cdd:cd02193 2 GEAMKI E E HN H P AAID P AA GA A TG V GG A IRD IAA TG ID A KPI A LS A NWMASAG H PGE ------------------- DAIL 62
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 383 IE A SN G ASDYG N KF G E P VLA G FA R SLGL --- Q LPDG QR REWIK P IMFSGGI G SMEAKHVGK - KPPEP G MEVVKV GG PVYR 458
Cdd:cd02193 63 YD A VK G VAELC N QL G L P IPV G KD R MSMK trw Q EGNE QR EMTHP P SLVISAF G RVRDDRHTL p QLSTE G NALLLI GG GKGH 142
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 459 I G V GG G A AS SV QVQGD nts D L DFGAV Q RG DP EM E QKMNRVIR A C V E A pgg NPICSL HD Q GAGG NGNV L K EL SDP -- E G AI 536
Cdd:cd02193 143 N G L GG T A LA SV ALSYR --- Q L GDKSA Q VR DP AQ E KGFYEAMQ A L V A A --- GKLLAW HD R GAGG LLVA L A EL VFA gh C G VQ 216
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 226958458 537 IYTSRFQLGD P TLNA LEI WGA E Y QE SNALLL R PS DRD FLSR A SARERCPACFV G 590
Cdd:cd02193 217 VDLAALGDDE P DMEP LEI ALF E S QE RGVIQV R AE DRD AVEE A QYGLADCVHVL G 270
FGAM_synth_I
TIGR01737 phosphoribosylformylglycinamidine synthase I; In some species, ...
1063-1301
1.67e-37
phosphoribosylformylglycinamidine synthase I; In some species, phosphoribosylformylglycinamidine synthase is composed of a single polypeptide chain. This model describes the PurQ protein of Bacillus subtilis (where PurL, PurQ, and PurS are required for phosphoribosylformylglycinamidine synthase activity) and functionally equivalent proteins from other bacteria and archaea. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273782 [Multi-domain]
Cd Length: 227
Bit Score: 140.98
E-value: 1.67e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1063 R VA IL R EE G S N G DR EMAD A FH L A G FEVWD V TMQ D L csgai R L DTFR GV AFV GGFSY A D V L GS ak G WA AA VTFNP Q ARE E L 1142
Cdd:TIGR01737 2 K VA VI R FP G T N C DR DTVY A LR L L G VDAEI V WYE D G ----- S L PDYD GV VLP GGFSY G D Y L RA -- G AI AA ASPIM Q EVR E F 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1143 GR f RRR P dtf S LG V CNG C Q L L ALL G WV gsdpseeqaepgqdsqptq PG L LL r H N L S G RF ES RW ATV RVE PGPALMLRGM - 1221
Cdd:TIGR01737 75 AE - KGV P --- V LG I CNG F Q I L VEA G LL ------------------- PG A LL - P N D S L RF IC RW VYL RVE NADTIFTKNY k 130
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1222 E G S V LPVWS AHGEG YMAFSSPE L q A KI E AKGL V PLHWA D D DG NPT E QY pl NPNGS P G G IAGI CSQD G RH L AL MPHPERA V 1301
Cdd:TIGR01737 131 K G E V IRIPI AHGEG RYYADDET L - A RL E SNDQ V VFRYC D E DG DVA E EA -- NPNGS V G N IAGI VNER G NV L GM MPHPERA S 207
PRK01175
PRK01175 phosphoribosylformylglycinamidine synthase I; Provisional
1062-1305
9.05e-36
phosphoribosylformylglycinamidine synthase I; Provisional
Pssm-ID: 234913 [Multi-domain]
Cd Length: 261
Bit Score: 137.20
E-value: 9.05e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1062 P RVA I LR E EG S N GDR E MAD AF HLA G F E VWD V TMQ DL CSGAIRLDTFRGVAFV GGFS YA D VLGSAKGW AA AV tf NPQA R EE 1141
Cdd:PRK01175 4 I RVA V LR M EG T N CED E TVK AF RRL G V E PEY V HIN DL AAERKSVSDYDCLVIP GGFS AG D YIRAGAIF AA RL -- KAVL R KD 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1142 LGR F RRR p DTFSL G V CNG C Q L L AL LG wvgsdpseeq AE PG Q D SQPTQ P GLL L RH N L S G RFE S R WATVRV E PGPALMLRGM 1221
Cdd:PRK01175 82 IEE F IDE - GYPII G I CNG F Q V L VE LG ---------- LL PG F D EIAEK P EMA L TV N E S N RFE C R PTYLKK E NRKCIFTKLL 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1222 EGS V LP V WS AH G EG YMA FS SP E LQAKIEAKGLVPLHWA D DD GN p TEQ YP L NPNGS PGG IAGI CSQD G RHLA LMPHPERA V 1301
Cdd:PRK01175 151 KKD V FQ V PV AH A EG RVV FS EE E ILERLIENDQIVFRYV D EN GN - YAG YP W NPNGS IYN IAGI TNEK G NVIG LMPHPERA F 229
....
gi 226958458 1302 RLW Q 1305
Cdd:PRK01175 230 YGY Q 233
PRK03619
PRK03619 phosphoribosylformylglycinamidine synthase subunit PurQ;
1063-1301
6.11e-29
phosphoribosylformylglycinamidine synthase subunit PurQ;
Pssm-ID: 235140 [Multi-domain]
Cd Length: 219
Bit Score: 115.98
E-value: 6.11e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1063 R VA ILREE GSN G DR E MA D A F - H L A G F E --- VW dvtmqdlc SGAIR LD TFRG V AFV GGFSY A D V L GS ak G WA AA vt F N P q A 1138
Cdd:PRK03619 2 K VA VIVFP GSN C DR D MA R A L r D L L G A E pey VW -------- HKETD LD GVDA V VLP GGFSY G D Y L RC -- G AI AA -- F S P - I 68
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1139 REELGR F RRR p DTFS LG V CNG C Q L L A --- LL gwvgsdpseeqaepgqdsqptq PG L L L R h N L S GR F ES R WATV RVE PGPA 1215
Cdd:PRK03619 69 MKAVKE F AEK - GKPV LG I CNG F Q I L T eag LL ---------------------- PG A L T R - N A S LK F IC R DVHL RVE NNDT 124
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1216 LMLR G M E - G S V L -- P V ws AHGEG - Y ma FSSP E LQAKI E AK G L V PLHWA D D dgnpteqypl NPNGS PGG IAGI CSQD G RH L 1291
Cdd:PRK03619 125 PFTS G Y E k G E V I ri P I -- AHGEG n Y -- YADE E TLKRL E GN G Q V VFRYC D E ---------- NPNGS VND IAGI VNEK G NV L 190
250
....*....|
gi 226958458 1292 AL MPHPERAV 1301
Cdd:PRK03619 191 GM MPHPERAV 200
AIRS_C
pfam02769 AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression ...
444-602
1.16e-25
AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression/formation protein HypE, AIR synthases EC:6.3.3.1, FGAM synthase EC:6.3.5.3 and selenide, water dikinase EC:2.7.9.3. The function of the C-terminal domain of AIR synthase is unclear, but the cleft formed between N and C domains is postulated as a sulphate binding site.
Pssm-ID: 460684 [Multi-domain]
Cd Length: 152
Bit Score: 104.35
E-value: 1.16e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 444 E PG MEVVKV G G pvyr I G VG G GAA S SVQVQGDNTSD ldf G AVQ R GDP EM E QKMNR V IRACVEA pg G NPICSL HD QGA GG NG 523
Cdd:pfam02769 1 K PG DVLILL G S ---- S G LH G AGL S LSRKGLEDSGL --- A AVQ L GDP LL E PTLIY V KLLLAAL -- G GLVKAM HD ITG GG LA 71
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 524 NV L K E LSDP -- E GA I I YTSRFQLGDPTLNA LE IWGA E Y Q ESNALLLR P SDRDFLSRASAR E RCP A CFV G TI T GDK R IVLV 601
Cdd:pfam02769 72 GA L A E MAPA sg V GA E I DLDKVPIFEELMLP LE MLLS E N Q GRGLVVVA P EEAEAVLAILEK E GLE A AVI G EV T AGG R LTVI 151
.
gi 226958458 602 D 602
Cdd:pfam02769 152 V 152
PurL
cd02193 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent ...
719-983
1.33e-25
Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100029 [Multi-domain]
Cd Length: 272
Bit Score: 108.15
E-value: 1.33e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 719 G A A TALG E QPVKSLL DP K A A A RLA V SE A LTN l VF A LVT D LRDVKC S G NWM WA A KL PGE G A A L A DA CEAMVAVMAA LG VAV 798
Cdd:cd02193 2 G E A MKIE E HNHPAAI DP A A G A ATG V GG A IRD - IA A TGI D AKPIAL S A NWM AS A GH PGE D A I L Y DA VKGVAELCNQ LG LPI 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 799 DG GKD SL SM AA R VGTETV Q APG ---- SLVISA YAVCP D ITA T V t P D L KHP G GK gh LL YVPLSP G QHR LGGTALA Q --- CF 871
Cdd:cd02193 81 PV GKD RM SM KT R WQEGNE Q REM thpp SLVISA FGRVR D DRH T L - P Q L STE G NA -- LL LIGGGK G HNG LGGTALA S val SY 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 872 S QLG EHPPDLDL P ENLVRAFHIT Q G L LKECR L CSG HD VSD GGL VTC L L E MA FAG N CG IE VD VP A ----- P GIHA L PV - LF 945
Cdd:cd02193 158 R QLG DKSAQVRD P AQEKGFYEAM Q A L VAAGK L LAW HD RGA GGL LVA L A E LV FAG H CG VQ VD LA A lgdde P DMEP L EI a LF 237
250 260 270
....*....|....*....|....*....|....*....
gi 226958458 946 AEEPGL V LE V QEA D vagv R QRY E S A GLRCLELG H T - G E A 983
Cdd:cd02193 238 ESQERG V IQ V RAE D ---- R DAV E E A QYGLADCV H V l G Q A 272
PRK14090
PRK14090 phosphoribosylformylglycinamidine synthase subunit PurL;
304-569
1.01e-15
phosphoribosylformylglycinamidine synthase subunit PurL;
Pssm-ID: 184499 [Multi-domain]
Cd Length: 601
Bit Score: 82.21
E-value: 1.01e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 304 VV F TA E T HN F P TGVA P FS GA T TG T GG R IRDV qc TGR GA HVV A gtagy C F GN LH I pdynlpwedpsfqypgnf A R PLEVA I 383
Cdd:PRK14090 63 IA F KI E S HN H P SAIE P YN GA A TG V GG I IRDV -- LAM GA RPT A ----- I F DS LH M ------------------ S R IIDGI I 117
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 384 E asn G AS DYGN KF G E P VLA G farsl G L QLPDGQRREWIKPIM f SG G IGSME a KH V GK K PPE PG MEV V KV GG PVY R I G VG G 463
Cdd:PRK14090 118 E --- G IA DYGN SI G V P TVG G ----- E L RISSLYAHNPLVNVL - AA G VVRND - ML V DS K ASR PG QVI V IF GG ATG R D G IH G 187
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 464 GAAS S VQVQ G DNTSD L dfg AV Q R GDP EM E QKM nrv I R A CV E APGGNPICSLH D Q GAGG NGNVLK EL -- SDPE GAI IYTS R 541
Cdd:PRK14090 188 ASFA S EDLT G EKATK L --- SI Q V GDP FA E KML --- I E A FL E MVEEGLVEGAQ D L GAGG VLSATS EL va KGGL GAI VHLD R 261
250 260
....*....|....*....|....*...
gi 226958458 542 FQ L GD P TLNAL EI WGA E Y QE SN A LLLR P 569
Cdd:PRK14090 262 VP L RE P DMEPW EI LIS E S QE RM A VVTS P 289
FGAR-AT_N
pfam18076 Formylglycinamide ribonucleotide amidotransferase N-terminal; This is the N-terminal domain ...
44-161
1.22e-14
Formylglycinamide ribonucleotide amidotransferase N-terminal; This is the N-terminal domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT), also known as Phosphoribosylformylglycinamidine synthase (EC:6.3.5.3), PurL and formylglycinamidine ribonucleotide (FGAM) synthase. This enzyme catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide and glutamine to formylglycinamidine ribonucleotide, ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway.
Pssm-ID: 465635 [Multi-domain]
Cd Length: 115
Bit Score: 71.35
E-value: 1.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 44 VH WAA -- ET L P w A E E MKK L MW L fgcp L VRDDVAQ EP wlvp GSNDL LL E V G PRL NFST P - A S -- T N I VSV C qaa GL R AV D R 118
Cdd:pfam18076 3 VH FVE le AP L S - A A E RAR L EQ L ---- L TYGPPLE EP ---- EPEGE LL L V T PRL GTIS P w S S ka T D I AHN C --- GL D AV R R 70
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 226958458 119 V E TTRR Y R L SFTDHPT AE ME A I s L A A LHDRMTE Q --- HYP D PIQS F 161
Cdd:pfam18076 71 I E RGIA Y Y L TGKPLSA AE LA A L - A A L LHDRMTE S vlt DLE D AAAL F 115
FGAR-AT_linker
pfam18072 Formylglycinamide ribonucleotide amidotransferase linker domain; This is the linker domain ...
184-232
1.93e-10
Formylglycinamide ribonucleotide amidotransferase linker domain; This is the linker domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT), also known as Phosphoribosylformylglycinamidine synthase (EC:6.3.5.3), PurL and formylglycinamidine ribonucleotide (FGAM) synthase. This enzyme catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway. The structure analysis of Salmonella typhimurium FGAR-AT reveals that this linker domain is made up of a long hydrophilic belt with an extended conformation.
Pssm-ID: 465632 [Multi-domain]
Cd Length: 50
Bit Score: 57.09
E-value: 1.93e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 226958458 184 LE K AN QE LGLAL DSWDL D FYTKR F QE L Q RNP ST VE VFDL AQ SN SEH S RH 232
Cdd:pfam18072 1 LE E AN RY LGLAL SDDEI D YLVEY F AG L G RNP TD VE LGMF AQ MW SEH C RH 49
AIRS_C
pfam02769 AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression ...
905-984
1.20e-09
AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression/formation protein HypE, AIR synthases EC:6.3.3.1, FGAM synthase EC:6.3.5.3 and selenide, water dikinase EC:2.7.9.3. The function of the C-terminal domain of AIR synthase is unclear, but the cleft formed between N and C domains is postulated as a sulphate binding site.
Pssm-ID: 460684 [Multi-domain]
Cd Length: 152
Bit Score: 58.13
E-value: 1.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 905 SG HD VSD GGL VTC L L EMA F A GNC G I E V D VPAP ----- GIHA L PV L FA E EP G - LVLE V QEADVAG V RQRY E SA GL RCLEL G 978
Cdd:pfam02769 61 AM HD ITG GGL AGA L A EMA P A SGV G A E I D LDKV pifee LMLP L EM L LS E NQ G r GLVV V APEEAEA V LAIL E KE GL EAAVI G 140
....*.
gi 226958458 979 HTGEA G 984
Cdd:pfam02769 141 EVTAG G 146
PurM-like
cd00396 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen ...
721-966
3.10e-07
AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain of AIR synthase forms the dimer interface of the protein, and is suggested as a putative ATP binding domain.
Pssm-ID: 100027 [Multi-domain]
Cd Length: 222
Bit Score: 52.78
E-value: 3.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 721 A TALGEQPVKSLLD P K A AA RLAV SE A LTNLV fal VTDL R DVKCSGNWMWAA kl PG E GAA L A D ACEAMVAVMAA LGV AVD G 800
Cdd:cd00396 3 A MSTDGINPPLAIN P W A GG RLAV GG A VNDIA --- AMGA R PIALLASLSLSN -- GL E VDI L E D VVDGVAEACNQ LGV PIV G 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 801 G KD S L S MA arvgtetvqapgslvisa YAVCPDIT A T vtpdlkhp GGK G HLLYVPLSPGQHRLG G TA L aqcfsqlgehppd 880
Cdd:cd00396 78 G HT S V S PG ------------------ TMGHKLSL A V -------- FAI G VVEKDRVIDSSGARP G DV L ------------- 118
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 881 ldlpen LVRAFHITQG L LKECRLCSG HD VS DGGL VTC L L E M A F A GNC G I E V D --- V P AP -------- GIHALPV LF AEEP 949
Cdd:cd00396 119 ------ ILTGVDAVLE L VAAGDVHAM HD IT DGGL LGT L P E L A Q A SGV G A E I D lea I P LD evvrwlcv EHIEEAL LF NSSG 192
250
....*....|....*....
gi 226958458 950 GL VLE V -- Q EAD VAGVRQR 966
Cdd:cd00396 193 GL LIA V pa E EAD AVLLLLN 211
GATase1
cd01653 Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase ...
1064-1165
5.79e-05
Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase (GATase1)-like domain. This group includes proteins similar to Class I glutamine amidotransferases, the intracellular PH1704 from Pyrococcus horikoshii, the C-terminal of the large catalase: Escherichia coli HP-II, Sinorhizobium meliloti Rm1021 ThuA. and, the A4 beta-galactosidase middle domain. The majority of proteins in this group have a reactive Cys found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For Class I glutamine amidotransferases proteins which transfer ammonia from the amide side chain of glutamine to an acceptor substrate, this Cys forms a Cys-His-Glu catalytic triad in the active site. Glutamine amidotransferases activity can be found in a range of biosynthetic enzymes included in this cd: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase, anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. For Pyrococcus horikoshii PH1704, the Cys of the nucleophile elbow together with a different His and, a Glu from an adjacent monomer form a catalytic triad different from the typical GATase1 triad. The E. coli HP-II C-terminal domain, S. meliloti Rm1021 ThuA and the A4 beta-galactosidase middle domain lack the catalytic triad typical GATaseI domains. GATase1-like domains can occur either as single polypeptides, as in Class I glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.
Pssm-ID: 153210 [Multi-domain]
Cd Length: 115
Bit Score: 43.74
E-value: 5.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1064 VA I L REE G SNGD -- REMA DA FHL AG F EV WD V TMQ - DLCSGAIR LD TFR G VAFV GG FSYA D V L gsakgwaaav TFNPQARE 1140
Cdd:cd01653 1 VA V L LFP G FEEL el ASPL DA LRE AG A EV DV V SPD g GPVESDVD LD DYD G LILP GG PGTP D D L ---------- ARDEALLA 70
90 100
....*....|....*....|....*
gi 226958458 1141 E L GRFRRR p DTFS LG V C N G C QLL A L 1165
Cdd:cd01653 71 L L REAAAA - GKPI LG I C L G A QLL V L 94
GAT_1
cd03128 Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase ...
1064-1163
3.81e-04
Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase (GATase1)-like domain. This group contains proteins similar to Class I glutamine amidotransferases, the intracellular PH1704 from Pyrococcus horikoshii, the C-terminal of the large catalase: Escherichia coli HP-II, Sinorhizobium meliloti Rm1021 ThuA, the A4 beta-galactosidase middle domain and peptidase E. The majority of proteins in this group have a reactive Cys found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For Class I glutamine amidotransferases proteins which transfer ammonia from the amide side chain of glutamine to an acceptor substrate, this Cys forms a Cys-His-Glu catalytic triad in the active site. Glutamine amidotransferases activity can be found in a range of biosynthetic enzymes included in this cd: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase, anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase (CPSase), cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. For Pyrococcus horikoshii PH1704, the Cys of the nucleophile elbow together with a different His and, a Glu from an adjacent monomer form a catalytic triad different from the typical GATase1 triad. Peptidase E is believed to be a serine peptidase having a Ser-His-Glu catalytic triad which differs from the Cys-His-Glu catalytic triad of typical GATase1 domains, by having a Ser in place of the reactive Cys at the nucleophile elbow. The E. coli HP-II C-terminal domain, S. meliloti Rm1021 ThuA and the A4 beta-galactosidase middle domain lack the catalytic triad typical GATaseI domains. GATase1-like domains can occur either as single polypeptides, as in Class I glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase. Peptidase E has a circular permutation in the common core of a typical GTAse1 domain.
Pssm-ID: 153222 [Multi-domain]
Cd Length: 92
Bit Score: 40.65
E-value: 3.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958458 1064 VA I L REE GS NGD -- REMA DA FHL AG F EV WD V TMQ - DLCSGAIR LD TFR G VAFV GG FSYA D V L gsakgwaaav TFNPQARE 1140
Cdd:cd03128 1 VA V L LFG GS EEL el ASPL DA LRE AG A EV DV V SPD g GPVESDVD LD DYD G LILP GG PGTP D D L ---------- AWDEALLA 70
90 100
....*....|....*....|...
gi 226958458 1141 E L GRFRRR p DTFS LG V C N G C QLL 1163
Cdd:cd03128 71 L L REAAAA - GKPV LG I C L G A QLL 92
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
