|
Name |
Accession |
Description |
Interval |
E-value |
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
250-598 |
2.64e-118 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 359.25 E-value: 2.64e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 250 VLRALSFLGFSAPTPIQALTLAPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQWhkmkappiprstgmppremrfgat 329
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIRDGKDVIGAAETGSGKTLAFGIPILERLLSQ------------------------ 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 330 ahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfdA 409
Cdd:cd17946 57 -------------------------------------------------------------------------------K 57
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 410 EQAGKLKqelcdqiaiykvhPRRPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIA 489
Cdd:cd17946 58 SSNGVGG-------------KQKPLRALILTPTRELAVQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVA 124
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 490 TPGRLWELVKEKHPHLSNLRQLRCLVIDEADRMVEKGHFAELSQLLEMLNDSQ--YNPSRQTLVFSATLTLVHQAPARIL 567
Cdd:cd17946 125 TPGRLWELIQEGNEHLANLKSLRFLVLDEADRMLEKGHFAELEKILELLNKDRagKKRKRQTFVFSATLTLDHQLPLKLN 204
|
330 340 350
....*....|....*....|....*....|.
gi 226958385 568 HKKHVKKMDKTDKLDLLMQKVGMRGKPKVID 598
Cdd:cd17946 205 SKKKKKKKEKKQKLELLIEKVGFRKKPKVID 235
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
243-776 |
1.38e-92 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 298.98 E-value: 1.38e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 243 DLFVPKAVLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHsvlqwhkmkappiprstgmppr 322
Cdd:COG0513 6 DLGLSPPLLKALAELGYTTPTPIQAQAI-PLILAGRDVLGQAQTGTGKTAAFLLPLLQ---------------------- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 323 emrfgatahlgspckdrtesgvlpeeaRIETEAQPsdsGVQAtpetsasasaqtllvcdddagegpssleekpvpkqned 402
Cdd:COG0513 63 ---------------------------RLDPSRPR---APQA-------------------------------------- 74
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 403 geekfdaeqagklkqelcdqiaiykvhprrpllgLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNR 482
Cdd:COG0513 75 ----------------------------------LILAPTRELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKR 120
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 483 HPEIVIATPGRLWELVKEKHphLsNLRQLRCLVIDEADRMVEKGHFAELSQLLEMLNdsqynPSRQTLVFSATLtlvhqa 562
Cdd:COG0513 121 GVDIVVATPGRLLDLIERGA--L-DLSGVETLVLDEADRMLDMGFIEDIERILKLLP-----KERQTLLFSATM------ 186
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 563 PARIlhKKHVKKMdktdkldllmqkvgMRgKPKVIDLTRNEGTVETLTETKIHCETDEKDLYLYYFLMQY-PGRSLVFAN 641
Cdd:COG0513 187 PPEI--RKLAKRY--------------LK-NPVRIEVAPENATAETIEQRYYLVDKRDKLELLRRLLRDEdPERAIVFCN 249
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 642 SISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRS 721
Cdd:COG0513 250 TKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPEDPEDYVHRI 329
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 226958385 722 GRTARAASEGLSLMLIGPEDVINFKKIYKTLQKD---EDIPLF-PVQSKYMDVVKERIR 776
Cdd:COG0513 330 GRTGRAGAEGTAISLVTPDERRLLRAIEKLIGQKieeEELPGFePVEEKRLERLKPKIK 388
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
250-557 |
9.16e-52 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 179.56 E-value: 9.16e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 250 VLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHsvlqwhkmkappiprstgmppremrfgat 329
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAI-PLILSGRDVIGQAQTGSGKTLAFLLPILE----------------------------- 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 330 ahlgspckdrtesgvlpeeaRIETEAQPSDSGVQAtpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfda 409
Cdd:cd00268 51 --------------------KLLPEPKKKGRGPQA--------------------------------------------- 65
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 410 eqagklkqelcdqiaiykvhprrpllgLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIA 489
Cdd:cd00268 66 ---------------------------LVLAPTRELAMQIAEVARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVG 118
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226958385 490 TPGRLWELVKEKHPHLSNlrqLRCLVIDEADRMVEKGHFAELSQLLEMLndsqyNPSRQTLVFSATLT 557
Cdd:cd00268 119 TPGRLLDLIERGKLDLSN---VKYLVLDEADRMLDMGFEEDVEKILSAL-----PKDRQTLLFSATLP 178
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
251-748 |
2.46e-48 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 177.83 E-value: 2.46e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 251 LRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSVLQWhkmkappiPRSTGMPPREmrfgata 330
Cdd:PRK11192 13 LEALQDKGYTRPTAIQAEAIPPALDGR-DVLGSAPTGTGKTAAFLLPALQHLLDF--------PRRKSGPPRI------- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 331 hlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfdae 410
Cdd:PRK11192 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 411 qagklkqelcdqiaiykvhprrpllgLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIAT 490
Cdd:PRK11192 77 --------------------------LILTPTRELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVAT 130
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 491 PGRLWELVKEKHphlSNLRQLRCLVIDEADRMVEKGhFAELSQllEMLNDSQYNpsRQTLVFSATltlvhqapariLHKK 570
Cdd:PRK11192 131 PGRLLQYIKEEN---FDCRAVETLILDEADRMLDMG-FAQDIE--TIAAETRWR--KQTLLFSAT-----------LEGD 191
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 571 HVKKMDKtdklDLLMQKVGMRGKPkvidlTRNEgtvetltETKIH-----CETDEKDLYLYYFLMQYP--GRSLVFANSI 643
Cdd:PRK11192 192 AVQDFAE----RLLNDPVEVEAEP-----SRRE-------RKKIHqwyyrADDLEHKTALLCHLLKQPevTRSIVFVRTR 255
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 644 SCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGR 723
Cdd:PRK11192 256 ERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGR 335
|
490 500
....*....|....*....|....*
gi 226958385 724 TARAASEGLSLMLIGPEDVINFKKI 748
Cdd:PRK11192 336 TGRAGRKGTAISLVEAHDHLLLGKI 360
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
247-741 |
5.56e-47 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 174.60 E-value: 5.56e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 247 PKAVLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHSVlqwhkmkappiprstgmppremrf 326
Cdd:PRK11776 12 PPALLANLNELGYTEMTPIQAQSL-PAILAGKDVIAQAKTGSGKTAAFGLGLLQKL------------------------ 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 327 gatahlgspckdrtesgvlpeearieteaQPSDSGVQAtpetsasasaqtllvcdddagegpssleekpvpkqnedgeek 406
Cdd:PRK11776 67 -----------------------------DVKRFRVQA------------------------------------------ 75
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 407 fdaeqagklkqelcdqiaiykvhprrpllgLVLTPTRELAIQVRQHIDAVAKFTGiNTAILV--GGMSTQKQQRMLNRHP 484
Cdd:PRK11776 76 ------------------------------LVLCPTRELADQVAKEIRRLARFIP-NIKVLTlcGGVPMGPQIDSLEHGA 124
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 485 EIVIATPGRLWElvkekhpHLS----NLRQLRCLVIDEADRMVEKGHFAELSQLLemlndSQYNPSRQTLVFSATLtlvh 560
Cdd:PRK11776 125 HIIVGTPGRILD-------HLRkgtlDLDALNTLVLDEADRMLDMGFQDAIDAII-----RQAPARRQTLLFSATY---- 188
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 561 qaPARILHkkhvkkmdktdkldlLMQKVgMRgKPKVIdltrnegTVETLTE-TKI-----HCETDEKDLYLYYFLMQY-P 633
Cdd:PRK11776 189 --PEGIAA---------------ISQRF-QR-DPVEV-------KVESTHDlPAIeqrfyEVSPDERLPALQRLLLHHqP 242
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 634 GRSLVFANSISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRT 713
Cdd:PRK11776 243 ESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVINYELARD 322
|
490 500
....*....|....*....|....*...
gi 226958385 714 SEIYIHRSGRTARAASEGLSLMLIGPED 741
Cdd:PRK11776 323 PEVHVHRIGRTGRAGSKGLALSLVAPEE 350
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
609-737 |
4.94e-45 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 158.05 E-value: 4.94e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 609 LTETKIHCETDEKDLYLYYFLMQ--YPGRSLVFANSISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCV 686
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLLEklKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 226958385 687 LLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGRTARAASEGLSLMLI 737
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
239-754 |
2.10e-43 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 164.70 E-value: 2.10e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 239 SAWRDLFVPKAVLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSVLQwhkmkappiprstg 318
Cdd:PRK01297 87 TRFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGH-DAIGRAQTGTGKTAAFLISIINQLLQ-------------- 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 319 mppremrfgatahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleeKPVPK 398
Cdd:PRK01297 152 ---------------------------------------------------------------------------TPPPK 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 399 QNEDGEekfdaeqagklkqelcdqiaiykvhPRrpllGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQR 478
Cdd:PRK01297 157 ERYMGE-------------------------PR----ALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLK 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 479 MLN-RHPEIVIATPGRLWELVKEKHPHLSnlrQLRCLVIDEADRMVEKGHFAELSQLLEMlndSQYNPSRQTLVFSATLT 557
Cdd:PRK01297 208 QLEaRFCDILVATPGRLLDFNQRGEVHLD---MVEVMVLDEADRMLDMGFIPQVRQIIRQ---TPRKEERQTLLFSATFT 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 558 lvhqaparilhkkhvkkmdkTDKLDLLMQKVgmrGKPKVIDLTRNEGTVETLTETKIHCETDEKDLYLYYFLMQYP-GRS 636
Cdd:PRK01297 282 --------------------DDVMNLAKQWT---TDPAIVEIEPENVASDTVEQHVYAVAGSDKYKLLYNLVTQNPwERV 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 637 LVFANSISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEI 716
Cdd:PRK01297 339 MVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDD 418
|
490 500 510
....*....|....*....|....*....|....*...
gi 226958385 717 YIHRSGRTARAASEGLSLMLIGPEDVINFKKIYKTLQK 754
Cdd:PRK01297 419 YVHRIGRTGRAGASGVSISFAGEDDAFQLPEIEELLGR 456
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
243-748 |
9.28e-42 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 158.60 E-value: 9.28e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 243 DLFVPKAVLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSVLQwhkmkappiprstgmppr 322
Cdd:PRK04837 12 DFALHPQVVEALEKKGFHNCTPIQALALPLTLAGR-DVAGQAQTGTGKTMAFLTATFHYLLS------------------ 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 323 emrfgatahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleeKPVPKQNEd 402
Cdd:PRK04837 73 -----------------------------------------------------------------------HPAPEDRK- 80
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 403 geekfdaeqagklkqelcdqiaiyKVHPRrpllGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNR 482
Cdd:PRK04837 81 ------------------------VNQPR----ALIMAPTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLES 132
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 483 HPEIVIATPGRLWELVKEKHPHLSNLRqlrCLVIDEADRMVEKGHFAELSQLLEMLNDSQynpSRQTLVFSATLTLVHQA 562
Cdd:PRK04837 133 GVDILIGTTGRLIDYAKQNHINLGAIQ---VVVLDEADRMFDLGFIKDIRWLFRRMPPAN---QRLNMLFSATLSYRVRE 206
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 563 PArilhkkhVKKMDKTDKLDLL-MQKVGMRgkpkvidltrnegtvetLTETKIHCETDEKDLYLYYFLMQ-YPGRSLVFA 640
Cdd:PRK04837 207 LA-------FEHMNNPEYVEVEpEQKTGHR-----------------IKEELFYPSNEEKMRLLQTLIEEeWPDRAIIFA 262
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 641 NSI-SCIKRLS---------GLLKVlDVMpltlhacmhQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQV 710
Cdd:PRK04837 263 NTKhRCEEIWGhlaadghrvGLLTG-DVA---------QKKRLRILEEFTRGDLDILVATDVAARGLHIPAVTHVFNYDL 332
|
490 500 510
....*....|....*....|....*....|....*...
gi 226958385 711 PRTSEIYIHRSGRTARAASEGLSLMLIGPEDVINFKKI 748
Cdd:PRK04837 333 PDDCEDYVHRIGRTGRAGASGHSISLACEEYALNLPAI 370
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
247-740 |
3.67e-40 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 156.47 E-value: 3.67e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 247 PKAVLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIP-MIHsvlqwhkmkappiprstgmppremr 325
Cdd:PTZ00110 138 PDYILKSLKNAGFTEPTPIQVQGWPIALSGR-DMIGIAETGSGKTLAFLLPaIVH------------------------- 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 326 fgatahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasASAQTLLvcddDAGEGPssleekpvpkqnedgee 405
Cdd:PTZ00110 192 ----------------------------------------------INAQPLL----RYGDGP----------------- 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 406 kfdaeqagklkqelcdqiaiykvhprrplLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPE 485
Cdd:PTZ00110 205 -----------------------------IVLVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVE 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 486 IVIATPGRLWELVKEKhphLSNLRQLRCLVIDEADRMVEKGHFAELSQLLemlndSQYNPSRQTLVFSATLTLVHQAPAR 565
Cdd:PTZ00110 256 ILIACPGRLIDFLESN---VTNLRRVTYLVLDEADRMLDMGFEPQIRKIV-----SQIRPDRQTLMWSATWPKEVQSLAR 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 566 ILHKKHVKKMDktdkldllmqkVGMrgkpkvIDLTrnegTVETLTETKIHCETDEKDLYLYYFL---MQYPGRSLVFANS 642
Cdd:PTZ00110 328 DLCKEEPVHVN-----------VGS------LDLT----ACHNIKQEVFVVEEHEKRGKLKMLLqriMRDGDKILIFVET 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 643 ISCIKRLSGLLKvLDVMP-LTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRS 721
Cdd:PTZ00110 387 KKGADFLTKELR-LDGWPaLCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRI 465
|
490
....*....|....*....
gi 226958385 722 GRTARAASEGLSLMLIGPE 740
Cdd:PTZ00110 466 GRTGRAGAKGASYTFLTPD 484
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
241-557 |
4.35e-38 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 141.30 E-value: 4.35e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 241 WRDLFVPKAVLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSVLqwhkmkappiprstgmp 320
Cdd:cd17954 2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGR-DIIGLAETGSGKTAAFALPILQALL----------------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 321 premrfgatahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqn 400
Cdd:cd17954 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 401 edgeekfdaeqagklkqelcdqiaiykvHPRRPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRML 480
Cdd:cd17954 64 ----------------------------ENPQRFFALVLAPTRELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIAL 115
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 481 NRHPEIVIATPGRLWElvkekhpHLSN-----LRQLRCLVIDEADRMVEKGHFAELSQLLEMLndsqynPS-RQTLVFSA 554
Cdd:cd17954 116 AKKPHVIVATPGRLVD-------HLENtkgfsLKSLKFLVMDEADRLLNMDFEPEIDKILKVI------PReRTTYLFSA 182
|
...
gi 226958385 555 TLT 557
Cdd:cd17954 183 TMT 185
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
249-785 |
1.33e-37 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 149.33 E-value: 1.33e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 249 AVLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSVLQwhkmkappiprstgmppremrfga 328
Cdd:PRK04537 19 ALLAGLESAGFTRCTPIQALTLPVALPGG-DVAGQAQTGTGKTLAFLVAVMNRLLS------------------------ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 329 tahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddageGPSSLEEKPvpkqnEDgeekfd 408
Cdd:PRK04537 74 ----------------------------------------------------------RPALADRKP-----ED------ 84
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 409 aeqagklkqelcdqiaiykvhPRrpllGLVLTPTRELAIQVrqHIDAVaKF---TGINTAILVGGMSTQKQQRMLNRHPE 485
Cdd:PRK04537 85 ---------------------PR----ALILAPTRELAIQI--HKDAV-KFgadLGLRFALVYGGVDYDKQRELLQQGVD 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 486 IVIATPGRLWELVKEkHPHLSnLRQLRCLVIDEADRMVEKGHFAELSQLLEMLNDsqyNPSRQTLVFSATLTlvHqapaR 565
Cdd:PRK04537 137 VIIATPGRLIDYVKQ-HKVVS-LHACEICVLDEADRMFDLGFIKDIRFLLRRMPE---RGTRQTLLFSATLS--H----R 205
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 566 ILHKKHvKKMDKTDKLdllmqkvgmrgkpkvidLTRNEGTVETLTETKIHCETDEKDLYLYYFLMQYP--GRSLVFANSI 643
Cdd:PRK04537 206 VLELAY-EHMNEPEKL-----------------VVETETITAARVRQRIYFPADEEKQTLLLGLLSRSegARTMVFVNTK 267
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 644 SCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGR 723
Cdd:PRK04537 268 AFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRIGR 347
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226958385 724 TARAASEGLSLMLIGPEDVINFKKIYKTLQkdEDIPLFPVQSKYMDVVKERIRLARQIEKAE 785
Cdd:PRK04537 348 TARLGEEGDAISFACERYAMSLPDIEAYIE--QKIPVEPVTAELLTPLPRPPRVPVEGEEAD 407
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
250-557 |
1.25e-36 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 136.62 E-value: 1.25e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 250 VLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSVLqwHKMKAPPIPRstgmppremrfgat 329
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGK-DICASAVTGSGKTAAFLLPILERLL--YRPKKKAATR-------------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 330 ahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfda 409
Cdd:cd17947 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 410 eqagklkqelcdqiaiykvhprrpllGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIA 489
Cdd:cd17947 64 --------------------------VLVLVPTRELAMQCFSVLQQLAQFTDITFALAVGGLSLKAQEAALRARPDIVIA 117
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226958385 490 TPGRLWELVkekHPHLS-NLRQLRCLVIDEADRMVEKGHFAELSQLLEMLNDsqynpSRQTLVFSATLT 557
Cdd:cd17947 118 TPGRLIDHL---RNSPSfDLDSIEILVLDEADRMLEEGFADELKEILRLCPR-----TRQTMLFSATMT 178
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
431-759 |
2.98e-36 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 143.02 E-value: 2.98e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 431 RRPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELvkeKHPHLSNLRQ 510
Cdd:PRK10590 73 RRPVRALILTPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDL---EHQNAVKLDQ 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 511 LRCLVIDEADRMVEKGHFAELSQLLEMLndsqyNPSRQTLVFSATLTLVHQAPA-RILHK-----------------KHV 572
Cdd:PRK10590 150 VEILVLDEADRMLDMGFIHDIRRVLAKL-----PAKRQNLLFSATFSDDIKALAeKLLHNpleievarrntaseqvtQHV 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 573 KKMDKTDKLDLLMQKVGMRGKPKVIDLTRNEGTVETLTETKihcetdEKDlylyyflmqypgrslvfansiscikrlsgl 652
Cdd:PRK10590 225 HFVDKKRKRELLSQMIGKGNWQQVLVFTRTKHGANHLAEQL------NKD------------------------------ 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 653 lkvlDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGRTARAASEGL 732
Cdd:PRK10590 269 ----GIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYELPNVPEDYVHRIGRTGRAAATGE 344
|
330 340
....*....|....*....|....*..
gi 226958385 733 SLMLIGPEDVINFKKIYKTLQKdeDIP 759
Cdd:PRK10590 345 ALSLVCVDEHKLLRDIEKLLKK--EIP 369
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
243-557 |
2.29e-34 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 130.42 E-value: 2.29e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 243 DLFVPKAVLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSvlqwhkmkappiprstgmppr 322
Cdd:cd17955 3 DLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGR-DVIGGAKTGSGKTAAFALPILQR--------------------- 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 323 emrfgatahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssLEEKPVpkqned 402
Cdd:cd17955 61 --------------------------------------------------------------------LSEDPY------ 66
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 403 geekfdaeqagklkqelcdqiAIYkvhprrpllGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNR 482
Cdd:cd17955 67 ---------------------GIF---------ALVLTPTRELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSK 116
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226958385 483 HPEIVIATPGRLWELVKEKHPHLSNLRQLRCLVIDEADRMVEKGHFAELSQLLEMLndsqyNPSRQTLVFSATLT 557
Cdd:cd17955 117 RPHIVVATPGRLADHLRSSDDTTKVLSRVKFLVLDEADRLLTGSFEDDLATILSAL-----PPKRQTLLFSATLT 186
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
248-556 |
3.13e-34 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 130.12 E-value: 3.13e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 248 KAVLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHsvlqwhkmkappiprstgmppremrfg 327
Cdd:cd17959 10 PPLLRAIKKKGYKVPTPIQRKTI-PLILDGRDVVAMARTGSGKTAAFLIPMIE--------------------------- 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 328 atahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqnedgeekf 407
Cdd:cd17959 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 408 daeqagKLKQElcdqiaiykvHPRRPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIV 487
Cdd:cd17959 62 ------KLKAH----------SPTVGARALILSPTRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDII 125
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226958385 488 IATPGRLWELVKEKHphlSNLRQLRCLVIDEADRMVEKGhFAElsQLLEMLndSQYNPSRQTLVFSATL 556
Cdd:cd17959 126 IATPGRLLHLLVEMN---LKLSSVEYVVFDEADRLFEMG-FAE--QLHEIL--SRLPENRQTLLFSATL 186
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
386-756 |
8.40e-31 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 125.71 E-value: 8.40e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 386 EGPSSLEEKPVpKQNEDGEEKFDAEQAGKLKQELCDQIAIYKVHPR-RPLLGLVLTPTRELAIQVRQHIDAVAKFTGINT 464
Cdd:PTZ00424 49 EKPSAIQQRGI-KPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDlNACQALILAPTRELAQQIQKVVLALGDYLKVRC 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 465 AILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKHPHLSNLRqlrCLVIDEADRMVEKGHFAELSQLLEMLNdsqyn 544
Cdd:PTZ00424 128 HACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDKRHLRVDDLK---LFILDEADEMLSRGFKGQIYDVFKKLP----- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 545 PSRQTLVFSATLtlvhqaPARILHkkhvkkmdktdkldlLMQKVgMRgKPKVIDLTRNEGTVETLTETKIHCETDE---- 620
Cdd:PTZ00424 200 PDVQVALFSATM------PNEILE---------------LTTKF-MR-DPKRILVKKDELTLEGIRQFYVAVEKEEwkfd 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 621 --KDLYLYYFLMQypgrSLVFANSISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLD 698
Cdd:PTZ00424 257 tlCDLYETLTITQ----AIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGID 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 699 IPKVQHVIHYQVPRTSEIYIHRSGRTARAASEGLSLMLIGPEDVINFKKI--YKTLQKDE 756
Cdd:PTZ00424 333 VQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIerHYNTQIEE 392
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
243-737 |
2.75e-30 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 127.66 E-value: 2.75e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 243 DLFVPKAVLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQwhKMKAPPIprstgmppr 322
Cdd:PRK11634 10 DLGLKAPILEALNDLGYEKPSPIQAECI-PHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDP--ELKAPQI--------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 323 emrfgatahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqned 402
Cdd:PRK11634 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 403 geekfdaeqagklkqelcdqiaiykvhprrpllgLVLTPTRELAIQVRQHIDAVAK-FTGINTAILVGGMSTQKQQRMLN 481
Cdd:PRK11634 78 ----------------------------------LVLAPTRELAVQVAEAMTDFSKhMRGVNVVALYGGQRYDVQLRALR 123
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 482 RHPEIVIATPGRLWELVKEKHPHLSNLRQlrcLVIDEADRMVEKGHFAELSQLLemlndSQYNPSRQTLVFSATLTlvhQ 561
Cdd:PRK11634 124 QGPQIVVGTPGRLLDHLKRGTLDLSKLSG---LVLDEADEMLRMGFIEDVETIM-----AQIPEGHQTALFSATMP---E 192
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 562 APARILhKKHVKkmdktDKLDLLMQKvGMRGKPkviDLTRNEGTVETLtetkihcetdEKDLYLYYFLmqypgRSLVFAN 641
Cdd:PRK11634 193 AIRRIT-RRFMK-----EPQEVRIQS-SVTTRP---DISQSYWTVWGM----------RKNEALVRFL-----EAEDFDA 247
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 642 SISCIKRLSGLLKVLDVMPLT------LHACMHQKQRLRNLEqfaRLQDC---VLLATDVAARGLDIPKVQHVIHYQVPR 712
Cdd:PRK11634 248 AIIFVRTKNATLEVAEALERNgynsaaLNGDMNQALREQTLE---RLKDGrldILIATDVAARGLDVERISLVVNYDIPM 324
|
490 500
....*....|....*....|....*
gi 226958385 713 TSEIYIHRSGRTARAASEGLSLMLI 737
Cdd:PRK11634 325 DSESYVHRIGRTGRAGRAGRALLFV 349
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
248-556 |
1.36e-29 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 116.91 E-value: 1.36e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 248 KAVLRALSFLGFSAPTPIQALTLAPAIRDKLDILGAAETGSGKTLAFAIPMIhsvlqwhkmkappiprstgmppremrfg 327
Cdd:cd17964 3 PSLLKALTRMGFETMTPVQQKTLKPILSTGDDVLARAKTGTGKTLAFLLPAI---------------------------- 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 328 atahlgspckdrtesgvlpeEARIETEAQPSDSGVQAtpetsasasaqtllvcdddagegpssleekpvpkqnedgeekf 407
Cdd:cd17964 55 --------------------QSLLNTKPAGRRSGVSA------------------------------------------- 71
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 408 daeqagklkqelcdqiaiykvhprrpllgLVLTPTRELAIQVRQHIDAVAKF-TGINTAILVGGMSTQKQ-QRMLNRHPE 485
Cdd:cd17964 72 -----------------------------LIISPTRELALQIAAEAKKLLQGlRKLRVQSAVGGTSRRAElNRLRRGRPD 122
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226958385 486 IVIATPGRLwelvkekHPHLSN------LRQLRCLVIDEADRMVEKGHFAELSQLLEMLNDSQYNPsRQTLVFSATL 556
Cdd:cd17964 123 ILVATPGRL-------IDHLENpgvakaFTDLDYLVLDEADRLLDMGFRPDLEQILRHLPEKNADP-RQTLLFSATV 191
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
263-557 |
3.50e-29 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 114.26 E-value: 3.50e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 263 TPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSVlqwhkmkappiprstgmppremrfgatahlgspckdrtes 342
Cdd:pfam00270 1 TPIQAEAIPAILEGR-DVLVQAPTGSGKTLAFLLPALEAL---------------------------------------- 39
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 343 gvlpeearieteaQPSDSGVQAtpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfdaeqagklkqelcdq 422
Cdd:pfam00270 40 -------------DKLDNGPQA---------------------------------------------------------- 48
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 423 iaiykvhprrpllgLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLnRHPEIVIATPGRLWELVKEKH 502
Cdd:pfam00270 49 --------------LVLAPTRELAEQIYEELKKLGKGLGLKVASLLGGDSRKEQLEKL-KGPDILVGTPGRLLDLLQERK 113
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 226958385 503 phlsNLRQLRCLVIDEADRMVEKGHFAELSQLLEMLndsqyNPSRQTLVFSATLT 557
Cdd:pfam00270 114 ----LLKNLKLLVLDEAHRLLDMGFGPDLEEILRRL-----PKKRQILLLSATLP 159
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
238-569 |
5.72e-29 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 115.55 E-value: 5.72e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 238 VSAWRDLFVPKAVLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHsvlqwHKMKAPPIprst 317
Cdd:cd17953 11 IQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQAL-PAIMSGRDVIGIAKTGSGKTLAFLLPMFR-----HIKDQRPV---- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 318 gmppremrfgatahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcddDAGEGPssleekpvp 397
Cdd:cd17953 81 -----------------------------------------------------------------KPGEGP--------- 86
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 398 kqnedgeekfdaeqagklkqelcdqiaiykvhprrplLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQ 477
Cdd:cd17953 87 -------------------------------------IGLIMAPTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQI 129
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 478 RMLNRHPEIVIATPGRLWELVKEKHPHLSNLRQLRCLVIDEADRMVEKGHFAELSQLLEmlndsQYNPSRQTLVFSATL- 556
Cdd:cd17953 130 AELKRGAEIVVCTPGRMIDILTANNGRVTNLRRVTYVVLDEADRMFDMGFEPQIMKIVN-----NIRPDRQTVLFSATFp 204
|
330
....*....|...
gi 226958385 557 TLVHQAPARILHK 569
Cdd:cd17953 205 RKVEALARKVLHK 217
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
420-753 |
1.25e-28 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 121.43 E-value: 1.25e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 420 CDQIAIYKVHPRRPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVK 499
Cdd:PLN00206 183 CCTIRSGHPSEQRNPLAMVLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLS 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 500 EkhpHLSNLRQLRCLVIDEADRMVEKGHFAELSQLLEMLndsqynPSRQTLVFSATLTlvhqaparilhkKHVKKMDKTD 579
Cdd:PLN00206 263 K---HDIELDNVSVLVLDEVDCMLERGFRDQVMQIFQAL------SQPQVLLFSATVS------------PEVEKFASSL 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 580 KLDLLMQKVGMRGKPKvidltrnegtvETLTETKIHCETDEKDLYLYYFLM---QYPGRSLVFANSISCIKRLS-GLLKV 655
Cdd:PLN00206 322 AKDIILISIGNPNRPN-----------KAVKQLAIWVETKQKKQKLFDILKskqHFKPPAVVFVSSRLGADLLAnAITVV 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 656 LDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGRTARAASEGLSLM 735
Cdd:PLN00206 391 TGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIV 470
|
330
....*....|....*...
gi 226958385 736 LIGPEDVINFKKIYKTLQ 753
Cdd:PLN00206 471 FVNEEDRNLFPELVALLK 488
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
250-556 |
1.38e-28 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 113.66 E-value: 1.38e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 250 VLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIhsvlqWHKMKAPPIprstgmppremrfgat 329
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGR-DMIGIAKTGSGKTAAFIWPML-----VHIMDQREL---------------- 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 330 ahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcddDAGEGPssleekpvpkqnedgeekfda 409
Cdd:cd17952 59 -----------------------------------------------------EKGEGP--------------------- 64
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 410 eqagklkqelcdqiaiykvhprrplLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIA 489
Cdd:cd17952 65 -------------------------IAVIVAPTRELAQQIYLEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVA 119
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226958385 490 TPGRLWELVKEKhphLSNLRQLRCLVIDEADRMVEKGhFAelSQLLEMLNdsQYNPSRQTLVFSATL 556
Cdd:cd17952 120 TPGRLIDMVKKK---ATNLQRVTYLVLDEADRMFDMG-FE--YQVRSIVG--HVRPDRQTLLFSATF 178
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
250-557 |
1.42e-27 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 111.64 E-value: 1.42e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 250 VLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSVLQwhkmkAPPIPRSTGMppremrfgat 329
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNR-DIIGIAETGSGKTAAFLIPLLVYISR-----LPPLDEETKD---------- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 330 ahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagEGPssleekpvpkqnedgeekfda 409
Cdd:cd17945 65 --------------------------------------------------------DGP--------------------- 67
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 410 eqagklkqelcdqiaiykvhprrplLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIA 489
Cdd:cd17945 68 -------------------------YALILAPTRELAQQIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIA 122
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 490 TPGRLWELVkEKhpHLSNLRQLRCLVIDEADRMVEKGhFAE-----LSQL-----------LEMLNDSQYNPSRQTLVFS 553
Cdd:cd17945 123 TPGRLLDCL-ER--RLLVLNQCTYVVLDEADRMIDMG-FEPqvtkiLDAMpvsnkkpdteeAEKLAASGKHRYRQTMMFT 198
|
....
gi 226958385 554 ATLT 557
Cdd:cd17945 199 ATMP 202
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
250-555 |
8.37e-27 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 108.61 E-value: 8.37e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 250 VLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPmihsvlqwhkmkappiprstgmppremrfgAT 329
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGR-DMVGIAQTGSGKTLAFLLP------------------------------AI 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 330 AHLgspckdrtesgvlpeearieteaqpsdsgvqatpetsasaSAQTLLvcddDAGEGPssleekpvpkqnedgeekfda 409
Cdd:cd17966 50 VHI----------------------------------------NAQPPL----ERGDGP--------------------- 64
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 410 eqagklkqelcdqiaiykvhprrplLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIA 489
Cdd:cd17966 65 -------------------------IVLVLAPTRELAQQIQQEANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIA 119
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226958385 490 TPGRLWELVKEKHphlSNLRQLRCLVIDEADRMVEKGHFAELSQLLemlndSQYNPSRQTLVFSAT 555
Cdd:cd17966 120 TPGRLIDFLDQGK---TNLRRVTYLVLDEADRMLDMGFEPQIRKIV-----DQIRPDRQTLMWSAT 177
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
250-557 |
5.72e-26 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 106.51 E-value: 5.72e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 250 VLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSVLqwhkmkappiprstgmppremrfgat 329
Cdd:cd17961 5 LLKAIAKLGWEKPTLIQSKAIPLALEGK-DILARARTGSGKTAAYALPIIQKIL-------------------------- 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 330 ahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfda 409
Cdd:cd17961 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 410 eqagKLKQELCDQIAIYkvhprrpllGLVLTPTRELAIQVRQHIDAVAKFTG--INTAILVGGMSTQKQQRMLNRHPEIV 487
Cdd:cd17961 58 ----KAKAESGEEQGTR---------ALILVPTRELAQQVSKVLEQLTAYCRkdVRVVNLSASSSDSVQRALLAEKPDIV 124
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226958385 488 IATPGRLWELVKEKhpHLSNLRQLRCLVIDEADRMVEKGHFAELSQLLEMLndsqynPSR-QTLVFSATLT 557
Cdd:cd17961 125 VSTPARLLSHLESG--SLLLLSTLKYLVIDEADLVLSYGYEEDLKSLLSYL------PKNyQTFLMSATLS 187
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
258-556 |
1.13e-25 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 106.03 E-value: 1.13e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 258 GFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLqwhkMKAPPIPRSTGMPpremrfgatahlgspck 337
Cdd:cd17967 19 GYTKPTPVQKYAI-PIILAGRDLMACAQTGSGKTAAFLLPIISKLL----EDGPPSVGRGRRK----------------- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 338 drtesgvlpeearieteAQPSdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfdaeqagklkq 417
Cdd:cd17967 77 -----------------AYPS----------------------------------------------------------- 80
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 418 elcdqiaiykvhprrpllGLVLTPTRELAIQvrqhIDAVA-KF---TGINTAILVGGMSTQKQQRMLNRHPEIVIATPGR 493
Cdd:cd17967 81 ------------------ALILAPTRELAIQ----IYEEArKFsyrSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGR 138
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226958385 494 LWELVKEkhpHLSNLRQLRCLVIDEADRMVEKGhFaeLSQLLEMLNDSQYNP--SRQTLVFSATL 556
Cdd:cd17967 139 LVDFIER---GRISLSSIKFLVLDEADRMLDMG-F--EPQIRKIVEHPDMPPkgERQTLMFSATF 197
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
620-727 |
4.01e-25 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 100.75 E-value: 4.01e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 620 EKDLYLYYFLMQYPG-RSLVFANSISCIKrLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLD 698
Cdd:pfam00271 1 EKLEALLELLKKERGgKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79
|
90 100
....*....|....*....|....*....
gi 226958385 699 IPKVQHVIHYQVPRTSEIYIHRSGRTARA 727
Cdd:pfam00271 80 LPDVDLVINYDLPWNPASYIQRIGRAGRA 108
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
251-557 |
3.20e-23 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 98.13 E-value: 3.20e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 251 LRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHS--VLQWhkmkappiprstgmppremrfga 328
Cdd:cd17941 2 LKGLKEAGFIKMTEIQRDSIPHALQGR-DILGAAKTGSGKTLAFLVPLLEKlyRERW----------------------- 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 329 tahlgspckdrtesgvlpeearieteaqpsdsgvqaTPEtsasasaqtllvcdddagegpssleekpvpkqneDGeekfd 408
Cdd:cd17941 58 ------------------------------------TPE----------------------------------DG----- 62
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 409 aeqagklkqelcdqiaiykvhprrplLG-LVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHpEIV 487
Cdd:cd17941 63 --------------------------LGaLIISPTRELAMQIFEVLRKVGKYHSFSAGLIIGGKDVKEEKERINRM-NIL 115
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 488 IATPGRLWELVKEKhPHLsNLRQLRCLVIDEADRMVEKGHFAELSQLLEMLndsqyNPSRQTLVFSATLT 557
Cdd:cd17941 116 VCTPGRLLQHMDET-PGF-DTSNLQMLVLDEADRILDMGFKETLDAIVENL-----PKSRQTLLFSATQT 178
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
422-557 |
3.50e-23 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 98.33 E-value: 3.50e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 422 QIAIYKVHPRRPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQ-QRMLNRHPEIVIATPGRLWELVKE 500
Cdd:smart00487 43 LPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLYGGDSKREQlRKLESGKTDILVTTPGRLLDLLEN 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 226958385 501 KHPHLSNlrqLRCLVIDEADRMVEKGHFAELSQLLEMLndsqyNPSRQTLVFSATLT 557
Cdd:smart00487 123 DKLSLSN---VDLVILDEAHRLLDGGFGDQLEKLLKLL-----PKNVQLLLLSATPP 171
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
437-575 |
3.86e-23 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 98.16 E-value: 3.86e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 437 LVLTPTRELAIQVRQHIDAVAKFTG---INTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKhphLSNLRQLRC 513
Cdd:cd17938 64 LILEPSRELAEQTYNCIENFKKYLDnpkLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTG---KLDLSSVRF 140
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226958385 514 LVIDEADRMVEKGHFAELSQLLEMLNDSQYNPSR-QTLVFSATltlvhqapariLHKKHVKKM 575
Cdd:cd17938 141 FVLDEADRLLSQGNLETINRIYNRIPKITSDGKRlQVIVCSAT-----------LHSFEVKKL 192
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
250-556 |
7.41e-23 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 97.41 E-value: 7.41e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 250 VLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQwHKMKAPPIPrstgmppremrfgat 329
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGL-PTILSGRDMIGIAFTGSGKTLVFTLPLIMFALE-QEKKLPFIK--------------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 330 ahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddaGEGPssleekpvpkqnedgeekfda 409
Cdd:cd17951 64 -------------------------------------------------------GEGP--------------------- 67
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 410 eqagklkqelcdqiaiykvhprrplLGLVLTPTRELAIQVRQHIDAVAK------FTGINTAILVGGMSTQKQQRMLNRH 483
Cdd:cd17951 68 -------------------------YGLIVCPSRELARQTHEVIEYYCKalqeggYPQLRCLLCIGGMSVKEQLEVIRKG 122
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226958385 484 PEIVIATPGRLWELVKEKhphLSNLRQLRCLVIDEADRMVEKGHFAELSQLLemlndSQYNPSRQTLVFSATL 556
Cdd:cd17951 123 VHIVVATPGRLMDMLNKK---KINLDICRYLCLDEADRMIDMGFEEDIRTIF-----SYFKGQRQTLLFSATM 187
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
436-557 |
1.59e-22 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 96.49 E-value: 1.59e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 436 GLVLTPTRELAIQVRQHIDAVAKFTG--INTAILVGGMSTQKQQRMLNRH-PEIVIATPGRLWELVKEKHpHLSNLRQLR 512
Cdd:cd17960 66 ALIISPTRELATQIYEVLQSFLEHHLpkLKCQLLIGGTNVEEDVKKFKRNgPNILVGTPGRLEELLSRKA-DKVKVKSLE 144
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 226958385 513 CLVIDEADRMVEKGHFAELSQLLEMLndsqynP-SRQTLVFSATLT 557
Cdd:cd17960 145 VLVLDEADRLLDLGFEADLNRILSKL------PkQRRTGLFSATQT 184
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
251-566 |
1.79e-22 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 95.89 E-value: 1.79e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 251 LRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIhsvlqwhkmkappiprstgmppremrfgata 330
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGR-DVLGAAKTGSGKTLAFLIPAI------------------------------- 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 331 hlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfdae 410
Cdd:cd17942 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 411 qagklkqELcdqiaIYKVH--PRRPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVI 488
Cdd:cd17942 50 -------EL-----LYKLKfkPRNGTGVIIISPTRELALQIYGVAKELLKYHSQTFGIVIGGANRKAEAEKLGKGVNILV 117
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 489 ATPGRLWElvkekhpHLSN-----LRQLRCLVIDEADRMVEKGHFAELSQLLEMLndsqynPS-RQTLVFSATLTLVHQA 562
Cdd:cd17942 118 ATPGRLLD-------HLQNtkgflYKNLQCLIIDEADRILEIGFEEEMRQIIKLL------PKrRQTMLFSATQTRKVED 184
|
....
gi 226958385 563 PARI 566
Cdd:cd17942 185 LARI 188
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
647-727 |
2.42e-22 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 91.50 E-value: 2.42e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 647 KRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGRTAR 726
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
.
gi 226958385 727 A 727
Cdd:smart00490 81 A 81
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
422-557 |
9.58e-22 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 95.01 E-value: 9.58e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 422 QIAIYKVHPRrpLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMST--QKQQRMLNRH------PEIVIATPGR 493
Cdd:cd17956 59 QALSKRVVPR--LRALIVVPTKELVQQVYKVFESLCKGTGLKVVSLSGQKSFkkEQKLLLVDTSgrylsrVDILVATPGR 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 494 LWELVKEKHPHlsNLRQLRCLVIDEADRMVEKGHFAELSQLLE-----------------MLNDSQYNPsrQTLVFSATL 556
Cdd:cd17956 137 LVDHLNSTPGF--TLKHLRFLVIDEADRLLNQSFQDWLETVMKalgrptapdlgsfgdanLLERSVRPL--QKLLFSATL 212
|
.
gi 226958385 557 T 557
Cdd:cd17956 213 T 213
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
258-555 |
2.48e-21 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 94.65 E-value: 2.48e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 258 GFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIhsvlqwhkmkappiprsTGMppreMRFGATAhlgspck 337
Cdd:cd18052 62 GYEKPTPVQKYAI-PIILAGRDLMACAQTGSGKTAAFLLPVL-----------------TGM----MKEGLTA------- 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 338 drtesgvlpeearieteaqPSDSGVQaTPETsasasaqtllvcdddagegpssleekpvpkqnedgeekfdaeqagklkq 417
Cdd:cd18052 113 -------------------SSFSEVQ-EPQA------------------------------------------------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 418 elcdqiaiykvhprrpllgLVLTPTRELAIQVrqHIDAVaKF---TGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRL 494
Cdd:cd18052 124 -------------------LIVAPTRELANQI--FLEAR-KFsygTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRL 181
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226958385 495 WELV-KEKhphlSNLRQLRCLVIDEADRMVEKGHFAELSQLLEMLNDSQYNpSRQTLVFSAT 555
Cdd:cd18052 182 LDFIgRGK----ISLSKLKYLILDEADRMLDMGFGPEIRKLVSEPGMPSKE-DRQTLMFSAT 238
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
436-557 |
3.08e-21 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 92.39 E-value: 3.08e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 436 GLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKhpHLSnLRQLRCLV 515
Cdd:cd17939 68 ALVLAPTRELAQQIQKVVKALGDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRR--SLR-TDKIKMFV 144
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 226958385 516 IDEADRMVEKGHFAELSQLLEMLndsqyNPSRQTLVFSATLT 557
Cdd:cd17939 145 LDEADEMLSRGFKDQIYDIFQFL-----PPETQVVLFSATMP 181
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
257-557 |
5.13e-21 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 92.26 E-value: 5.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 257 LGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQwhkmKAPPIPRSTGmppremrfgatahlgspc 336
Cdd:cd17949 9 MGIEKPTAIQKLAI-PVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLS----LEPRVDRSDG------------------ 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 337 kdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfdaeqagklk 416
Cdd:cd17949 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 417 qelcdqiaiykvhprrpLLGLVLTPTRELAIQVRQHIDAVAK-FTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLW 495
Cdd:cd17949 66 -----------------TLALVLVPTRELALQIYEVLEKLLKpFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLL 128
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226958385 496 ElvkekhpHLSN-----LRQLRCLVIDEADRMVEKGHFAELSQLLEMLNDSQYN--------PSRQTLVFSATLT 557
Cdd:cd17949 129 D-------HLKNtqsfdVSNLRWLVLDEADRLLDMGFEKDITKILELLDDKRSKaggekskpSRRQTVLVSATLT 196
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
437-557 |
7.00e-20 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 88.94 E-value: 7.00e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 437 LVLTPTRELAIQVRQHIDAVAKF-TGINTAILVGGMSTQKQQRML-NRHPEIVIATPGRLWELVKEKHPHLSNLRQlrcL 514
Cdd:cd17950 74 LVICHTRELAFQISNEYERFSKYmPNVKTAVFFGGVPIKKDIEVLkNKCPHIVVGTPGRILALVREKKLKLSHVKH---F 150
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 226958385 515 VIDEADRMVEKghfaelsqlLEMLNDSQ-----YNPSRQTLVFSATLT 557
Cdd:cd17950 151 VLDECDKMLEQ---------LDMRRDVQeifraTPHDKQVMMFSATLS 189
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
250-557 |
1.77e-19 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 87.26 E-value: 1.77e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 250 VLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQWHKmkappiprstgmppremrfgat 329
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAI-PILLHGRDLLACAPTGSGKTLAFLIPILQKLGKPRK---------------------- 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 330 ahlgspckdrtesgvlpeearieteaqpsDSGVQAtpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfda 409
Cdd:cd17957 58 -----------------------------KKGLRA--------------------------------------------- 63
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 410 eqagklkqelcdqiaiykvhprrpllgLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMS-TQKQQRMLNRHPEIVI 488
Cdd:cd17957 64 ---------------------------LILAPTRELASQIYRELLKLSKGTGLRIVLLSKSLEaKAKDGPKSITKYDILV 116
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226958385 489 ATPGRLWELVKEKHPHLSNLRQlrcLVIDEADRMVEKGhFAElsQLLEMLNDSQyNPSRQTLVFSATLT 557
Cdd:cd17957 117 STPLRLVFLLKQGPIDLSSVEY---LVLDEADKLFEPG-FRE--QTDEILAACT-NPNLQRSLFSATIP 178
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
431-555 |
4.97e-19 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 85.78 E-value: 4.97e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 431 RRPLLGLVLTPTRELAIQVRQHIDAVA-KFTGINTAILVGGMSTQKQQRMLNRhPEIVIATPGRLWELVKEkhpHLSNLR 509
Cdd:cd17943 56 RRHPQVLILAPTREIAVQIHDVFKKIGkKLEGLKCEVFIGGTPVKEDKKKLKG-CHIAVGTPGRIKQLIEL---GALNVS 131
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 226958385 510 QLRCLVIDEADRMVEKGHFAELSQLLEMLNDsqynpSRQTLVFSAT 555
Cdd:cd17943 132 HVRLFVLDEADKLMEGSFQKDVNWIFSSLPK-----NKQVIAFSAT 172
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
250-588 |
8.84e-19 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 86.27 E-value: 8.84e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 250 VLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQWHKMKAPPIPrstgmppremrfgat 329
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGI-PSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEGPFN--------------- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 330 ahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfda 409
Cdd:cd17948 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 410 eqagklkqelcdqiaiykvHPRrpllGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGmstQKQQRMLNRH---PEI 486
Cdd:cd17948 65 -------------------APR----GLVITPSRELAEQIGSVAQSLTEGLGLKVKVITGG---RTKRQIRNPHfeeVDI 118
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 487 VIATPGRLWELVKEkhpHLSNLRQLRCLVIDEADRMVEKGHFAELSQLLE--------MLNDSQYNPSRQTLVFSATLtl 558
Cdd:cd17948 119 LVATPGALSKLLTS---RIYSLEQLRHLVLDEADTLLDDSFNEKLSHFLRrfplasrrSENTDGLDPGTQLVLVSATM-- 193
|
330 340 350
....*....|....*....|....*....|....*...
gi 226958385 559 vhqaPAR---ILHKkhVKKMD-----KTDKLDLLMQKV 588
Cdd:cd17948 194 ----PSGvgeVLSK--VIDVDsietvTSDKLHRLMPHV 225
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
435-573 |
3.02e-18 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 83.75 E-value: 3.02e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 435 LGLVLTPTRELAIQV-RQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEkhpHLSNLRQLRC 513
Cdd:cd17962 60 SALILTPTRELAVQIeDQAKELMKGLPPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQ---SSVELDNIKI 136
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 514 LVIDEADRMVEKGHFAELSQLLEMLNDSQynpsrQTLVFSATLTLVHQAPARILHKKHVK 573
Cdd:cd17962 137 VVVDEADTMLKMGFQQQVLDILENISHDH-----QTILVSATIPRGIEQLAGQLLQNPVR 191
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
436-555 |
4.93e-18 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 83.01 E-value: 4.93e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 436 GLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNrhpEIVIATPGRLWELVKEKhphLSNLRQLRCLV 515
Cdd:cd17963 67 ALCLAPTRELARQIGEVVEKMGKFTGVKVALAVPGNDVPRGKKITA---QIVIGTPGTVLDWLKKR---QLDLKKIKILV 140
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 226958385 516 IDEADRMVEKGHFAELSQ-LLEMLndsqyNPSRQTLVFSAT 555
Cdd:cd17963 141 LDEADVMLDTQGHGDQSIrIKRML-----PRNCQILLFSAT 176
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
437-555 |
6.15e-18 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 83.91 E-value: 6.15e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 437 LVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKHphlSNLRQLRCLVI 516
Cdd:cd18049 101 LVLAPTRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGK---TNLRRCTYLVL 177
|
90 100 110
....*....|....*....|....*....|....*....
gi 226958385 517 DEADRMVEKGHFAELSQLLEmlndsQYNPSRQTLVFSAT 555
Cdd:cd18049 178 DEADRMLDMGFEPQIRKIVD-----QIRPDRQTLMWSAT 211
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
437-555 |
9.63e-18 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 84.29 E-value: 9.63e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 437 LVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKHphlSNLRQLRCLVI 516
Cdd:cd18050 139 LVLAPTRELAQQVQQVADDYGKSSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGK---TNLRRCTYLVL 215
|
90 100 110
....*....|....*....|....*....|....*....
gi 226958385 517 DEADRMVEKGHFAELSQLLEmlndsQYNPSRQTLVFSAT 555
Cdd:cd18050 216 DEADRMLDMGFEPQIRKIVD-----QIRPDRQTLMWSAT 249
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
432-557 |
3.51e-16 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 77.89 E-value: 3.51e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 432 RPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKHphlSNLRQL 511
Cdd:cd18045 66 RETQALILSPTRELAVQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRS---LRTRHI 142
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 226958385 512 RCLVIDEADRMVEKGHFAELSQLLEMLndsqyNPSRQTLVFSATLT 557
Cdd:cd18045 143 KMLVLDEADEMLNKGFKEQIYDVYRYL-----PPATQVVLVSATLP 183
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
436-555 |
5.25e-16 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 77.34 E-value: 5.25e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 436 GLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKHPHLSNLRQlrcLV 515
Cdd:cd17940 70 ALILVPTRELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKT---LV 146
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 226958385 516 IDEADRMVEKghfaELSQLLEMLNDSqYNPSRQTLVFSAT 555
Cdd:cd17940 147 LDEADKLLSQ----DFQPIIEKILNF-LPKERQILLFSAT 181
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
250-555 |
6.79e-16 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 77.12 E-value: 6.79e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 250 VLRALSFLGFSAPTPIQAlTLAPAIRDKLDILGAAETGSGKTLAFAIP-MIHSVLQwhkmkapPIPRstgmppremrfga 328
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQS-QAWPIILQGIDLIGVAQTGTGKTLAYLLPgFIHLDLQ-------PIPR------------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 329 tahlgspckdrtesgvlpeEARIeteaqpsdsgvqatpetsasasaqtllvcdddageGPSSLeekpvpkqnedgeekfd 408
Cdd:cd17958 60 -------------------EQRN-----------------------------------GPGVL----------------- 68
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 409 aeqagklkqelcdqiaiykvhprrpllglVLTPTRELAIQVRQHIDAVaKFTGINTAILVGGMSTQKQQRMLNRHPEIVI 488
Cdd:cd17958 69 -----------------------------VLTPTRELALQIEAECSKY-SYKGLKSVCVYGGGNRNEQIEDLSKGVDIII 118
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226958385 489 ATPGRLWELVKEkhpHLSNLRQLRCLVIDEADRMVEKGhFAelSQLLEMLNDSQynPSRQTLVFSAT 555
Cdd:cd17958 119 ATPGRLNDLQMN---NVINLKSITYLVLDEADRMLDMG-FE--PQIRKILLDIR--PDRQTIMTSAT 177
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
238-565 |
4.68e-15 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 75.85 E-value: 4.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 238 VSAWRDLFVPKAVLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQwhkmkappiprst 317
Cdd:cd18051 20 IETFSDLDLGEIIRNNIELARYTKPTPVQKHAI-PIIKSKRDLMACAQTGSGKTAAFLLPILSQIYE------------- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 318 gmppremrfgatahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagEGPssleekPVP 397
Cdd:cd18051 86 --------------------------------------------------------------------QGP------GES 91
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 398 KQNEDGeekfdaeQAGKLKQelcdqiaiykvHPrrplLGLVLTPTRELAIQVrqhIDAVAKFT---GINTAILVGGMSTQ 474
Cdd:cd18051 92 LPSESG-------YYGRRKQ-----------YP----LALVLAPTRELASQI---YDEARKFAyrsRVRPCVVYGGADIG 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 475 KQQRMLNRHPEIVIATPGRLWELVKEKHPHLSNLRQlrcLVIDEADRMVEKGHFAELSQLLEMLNdsqYNPS--RQTLVF 552
Cdd:cd18051 147 QQMRDLERGCHLLVATPGRLVDMLERGKIGLDYCKY---LVLDEADRMLDMGFEPQIRRIVEQDT---MPPTgeRQTLMF 220
|
330
....*....|...
gi 226958385 553 SATLTLVHQAPAR 565
Cdd:cd18051 221 SATFPKEIQMLAR 233
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
437-568 |
5.56e-15 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 74.40 E-value: 5.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 437 LVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKHPHLSNLRQlrcLVI 516
Cdd:cd18046 71 LVLAPTRELAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKM---FVL 147
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 226958385 517 DEADRMVEKGHFAELSQLLEMLndsqyNPSRQTLVFSATLtlvhqaPARILH 568
Cdd:cd18046 148 DEADEMLSRGFKDQIYDIFQKL-----PPDTQVVLLSATM------PNDVLE 188
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
437-555 |
4.77e-14 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 71.80 E-value: 4.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 437 LVLTPTRELAIQVRQHIDAVAKftGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKHPHLSNLRQLrclVI 516
Cdd:cd17944 68 LVLAPTRELANQVTKDFKDITR--KLSVACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHV---VL 142
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 226958385 517 DEADRMVEKGhFAElsQLLEMLN-----DSQYNPsrQTLVFSAT 555
Cdd:cd17944 143 DEVDQMLDMG-FAE--QVEEILSvsykkDSEDNP--QTLLFSAT 181
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
424-855 |
3.53e-11 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 66.97 E-value: 3.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 424 AIYKVHPRRPLLglVLTPTRELAIQvrqhidAVAKFTGINTAILVGGmstqkqqRMLNRHPEIVIATPGRLWelvkeKHP 503
Cdd:COG1061 120 LAAELLRGKRVL--VLVPRRELLEQ------WAEELRRFLGDPLAGG-------GKKDSDAPITVATYQSLA-----RRA 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 504 HLSNLRQLRCLVI-DEAdrmvekgHFAELSQLLEMLNdsqYNPSRQTLVFSATltlvhqaPARilhkkhvkkMDKTD-KL 581
Cdd:COG1061 180 HLDELGDRFGLVIiDEA-------HHAGAPSYRRILE---AFPAAYRLGLTAT-------PFR---------SDGREiLL 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 582 DLLMQKV-----------GMRGKPKVI----DLTRNEGTVETLTET---KIHCETDEKDLYLYYFLMQYPG--RSLVFAN 641
Cdd:COG1061 234 FLFDGIVyeyslkeaiedGYLAPPEYYgirvDLTDERAEYDALSERlreALAADAERKDKILRELLREHPDdrKTLVFCS 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 642 SISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQvPRTSE-IYIHR 720
Cdd:COG1061 314 SVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLR-PTGSPrEFIQR 392
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 721 SGRTARAASEG--LSLMLIGPEDVINFKKIYKTLQKDE------------DIPLFPVQSKYMDVVKERIRLARQIEKAEY 786
Cdd:COG1061 393 LGRGLRPAPGKedALVYDFVGNDVPVLEELAKDLRDLAgyrvefldeeesEELALLIAVKPALEVKGELEEELLEELELL 472
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226958385 787 RNFQACLHNSWIEQAAAALEIELEEEMYKGGKADQQEERRRQKQMKMLKQELRHLLSQPLFQENLKTRY 855
Cdd:COG1061 473 EDALLLVLAELLLLELLALALELLELAKAEGKAEEEEEEKELLLLLALAKLLKLLLLLLLLLLLELLEL 541
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
437-555 |
4.34e-09 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 55.87 E-value: 4.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 437 LVLTPTRELAIQVRQHIDAVAKfTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKHPHLsnLRQLRCLVI 516
Cdd:cd00046 34 LVLVPTKALALQTAERLRELFG-PGIRVAVLVGGSSAEEREKNKLGDADIIIATPDMLLNLLLREDRLF--LKDLKLIIV 110
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 226958385 517 DEADRMVEKGHFAELSQLLE---MLNDSqynpsrQTLVFSAT 555
Cdd:cd00046 111 DEAHALLIDSRGALILDLAVrkaGLKNA------QVILLSAT 146
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
667-729 |
4.67e-09 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 60.13 E-value: 4.67e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226958385 667 MHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQ-VPrtSEI-YIHRSGRTARAAS 729
Cdd:COG1111 395 LTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYEpVP--SEIrSIQRKGRTGRKRE 457
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
667-729 |
2.87e-08 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 57.58 E-value: 2.87e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226958385 667 MHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQ-VPrtSEI-YIHRSGRTARAAS 729
Cdd:PRK13766 407 MSQKEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSVDLVIFYEpVP--SEIrSIQRKGRTGRQEE 469
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
667-726 |
2.30e-07 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 50.82 E-value: 2.30e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226958385 667 MHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQvPRTSEI-YIHRSGRTAR 726
Cdd:cd18801 74 MSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYD-ASPSPIrMIQRMGRTGR 133
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
686-731 |
4.68e-07 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 48.08 E-value: 4.68e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 226958385 686 VLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGRTARAASEG 731
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDE 70
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
614-743 |
1.48e-06 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 51.68 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 614 IHCETDEKDLYLYYFLMQYPGRS-LVFANSISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATdV 692
Cdd:COG0514 210 VPKPPDDKLAQLLDFLKEHPGGSgIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT-I 288
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 226958385 693 A-ARGLDIPKVQHVIHYQVPRTSEIYIHRSGRTARAASEGLSLMLIGPEDVI 743
Cdd:COG0514 289 AfGMGIDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGPEDVA 340
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
635-708 |
1.82e-06 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 48.24 E-value: 1.82e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226958385 635 RSLVFANSISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDC--VLLATDVAARGLDIPKVQHVIHY 708
Cdd:cd18793 29 KVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIrvFLLSTKAGGVGLNLTAANRVILY 104
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
667-736 |
5.45e-06 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 46.82 E-value: 5.45e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226958385 667 MHQKQRLRNLEQFaRLQDC-VLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGRtARAASEGLSLML 736
Cdd:cd18802 74 MTQRKQKETLDKF-RDGELnLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR-ARAPNSKYILMV 142
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
618-726 |
5.90e-06 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 46.43 E-value: 5.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 618 TDEKDLYLYYFLMQYPGRS-LVFANSISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATdVA-AR 695
Cdd:cd18794 14 KDEKLDLLKRIKVEHLGGSgIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVAT-VAfGM 92
|
90 100 110
....*....|....*....|....*....|.
gi 226958385 696 GLDIPKVQHVIHYQVPRTSEIYIHRSGRTAR 726
Cdd:cd18794 93 GIDKPDVRFVIHYSLPKSMESYYQESGRAGR 123
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
234-304 |
6.12e-06 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 50.22 E-value: 6.12e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226958385 234 QKADVSAWRDlFVPKAVLRALSFLGFSAPTPIQALTLApAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQ 304
Cdd:COG1205 30 REARYAPWPD-WLPPELRAALKKRGIERLYSHQAEAIE-AARAGKNVVIATPTASGKSLAYLLPVLEALLE 98
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
388-579 |
1.24e-05 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 47.32 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 388 PSSLEEKPVPKQNEDGEEKFDAE-QAGKLKQE-----LCDQIAIYKVHPRrpllGLVLTPTRELAIQVRQHIDAVAKF-T 460
Cdd:cd18048 41 PSKIQENALPMMLADPPQNLIAQsQSGTGKTAafvlaMLSRVDALKLYPQ----CLCLSPTFELALQTGKVVEEMGKFcV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 461 GINTAILVGGMSTQKQQRMlnrHPEIVIATPGRLWELVKEKHphLSNLRQLRCLVIDEADRMVEKGHFAELSQLLEmlnd 540
Cdd:cd18048 117 GIQVIYAIRGNRPGKGTDI---EAQIVIGTPGTVLDWCFKLR--LIDVTNISVFVLDEADVMINVQGHSDHSVRVK---- 187
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 226958385 541 sQYNPSR-QTLVFSATL-TLVHQAPARILHKKHVKKMDKTD 579
Cdd:cd18048 188 -RSMPKEcQMLLFSATFeDSVWAFAERIVPDPNIIKLKKEE 227
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
404-525 |
3.20e-05 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 46.60 E-value: 3.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 404 EEKFDAEQAGKLKQELCDqiaiyKVHPRrpllGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRML-NR 482
Cdd:cd17965 89 QEQEPFEEAEEEYESAKD-----TGRPR----SVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSGFGPSYQRLQLaFK 159
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 226958385 483 HP-EIVIATPGRLWELVKEKhphLSNLRQLRCLVIDEADRMVEK 525
Cdd:cd17965 160 GRiDILVTTPGKLASLAKSR---PKILSRVTHLVVDEADTLFDR 200
|
|
| SF2_C_reverse_gyrase |
cd18798 |
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological ... |
674-747 |
5.05e-05 |
|
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350185 [Multi-domain] Cd Length: 174 Bit Score: 44.60 E-value: 5.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 674 RNLEQFARLQDCVLLAT----DVAARGLDIPK-VQHVIHYQVPRTSeiYIHRSGRTAR----AASEGLSLMLIGPEDVIN 744
Cdd:cd18798 63 KNLEKFEEGEIDVLIGVasyyGVLVRGIDLPErIKYAIFYGVPVTT--YIQASGRTSRlyagGLTKGLSVVLVDDPELFE 140
|
...
gi 226958385 745 FKK 747
Cdd:cd18798 141 ALK 143
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
625-742 |
2.00e-04 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 45.09 E-value: 2.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 625 LYYFLMQYPGRS-LVFANSISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFAR--LQdcVLLATDVAARGLDIPK 701
Cdd:PRK11057 227 LMRYVQEQRGKSgIIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRddLQ--IVVATVAFGMGINKPN 304
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 226958385 702 VQHVIHYQVPRTSEIYIHRSGRTARAASEGLSLMLIGPEDV 742
Cdd:PRK11057 305 VRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMLFYDPADM 345
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
437-556 |
5.64e-04 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 41.86 E-value: 5.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 437 LVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQrmlNRHPEIVIATPGRlWELVKEKHPHLsNLRQLRCLVI 516
Cdd:cd17921 50 VYIAPTRALVNQKEADLRERFGPLGKNVGLLTGDPSVNKLL---LAEADILVATPEK-LDLLLRNGGER-LIQDVRLVVV 124
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 226958385 517 DEAdRMVEKGHFAE-LSQLLEMLNdsQYNPSRQTLVFSATL 556
Cdd:cd17921 125 DEA-HLIGDGERGVvLELLLSRLL--RINKNARFVGLSATL 162
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
437-556 |
5.98e-04 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 42.01 E-value: 5.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 437 LVLTPTRELAIQVRQHIDAVAKF-TGINTAILVGGMSTQKQQRMLNrhpEIVIATPGRLWE-LVKEKhphLSNLRQLRCL 514
Cdd:cd18047 75 LCLSPTYELALQTGKVIEQMGKFyPELKLAYAVRGNKLERGQKISE---QIVIGTPGTVLDwCSKLK---FIDPKKIKVF 148
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 226958385 515 VIDEADRMV-EKGHFAELSQLLEMLNDSQynpsrQTLVFSATL 556
Cdd:cd18047 149 VLDEADVMIaTQGHQDQSIRIQRMLPRNC-----QMLLFSATF 186
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
259-293 |
1.48e-03 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 42.40 E-value: 1.48e-03
10 20 30
....*....|....*....|....*....|....*
gi 226958385 259 FSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLA 293
Cdd:COG1201 22 FGAPTPPQREAW-PAIAAGESTLLIAPTGSGKTLA 55
|
|
| DEXDc_FANCM |
cd18033 |
DEAH-box helicase domain of FANCM; Fanconi anemia group M (FANCM) protein is a DNA-dependent ... |
439-555 |
2.64e-03 |
|
DEAH-box helicase domain of FANCM; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, it binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA), and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, it efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. In vitro, on its own, it strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA. FANCM is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350791 [Multi-domain] Cd Length: 182 Bit Score: 40.00 E-value: 2.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 439 LTPTRELaiqVRQHIDAVAKFTGI---NTAILVGgmSTQKQQRM-LNRHPEIVIATPGRLWELVKEkhpHLSNLRQLRCL 514
Cdd:cd18033 52 MAPTKPL---VSQQIEACYKITGIpssQTAELTG--SVPPTKRAeLWASKRVFFLTPQTLENDLKE---GDCDPKSIVCL 123
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 226958385 515 VIDEADRMVEKGHFAELSQLLemlndSQYNPSRQTLVFSAT 555
Cdd:cd18033 124 VIDEAHRATGNYAYCQVVREL-----MRYNSHFRILALTAT 159
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
422-556 |
8.23e-03 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 39.88 E-value: 8.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 422 QIAIYKvHPRRPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKqqRMLNRhPEIVIATPGRLWELVKEK 501
Cdd:COG1204 56 ELAILK-ALLNGGKALYIVPLRALASEKYREFKRDFEELGIKVGVSTGDYDSDD--EWLGR-YDILVATPEKLDSLLRNG 131
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226958385 502 HphlSNLRQLRCLVIDEA----DRmvEKGHFAE--LSQLLEMlndsqyNPSRQTLVFSATL 556
Cdd:COG1204 132 P---SWLRDVDLVVVDEAhlidDE--SRGPTLEvlLARLRRL------NPEAQIVALSATI 181
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
461-557 |
9.22e-03 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 38.28 E-value: 9.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958385 461 GINTAILVGGMSTQKQQRMLNRHPE----IVIATPGRLW-ELVKEKHPHLSNLRQLRCLVIDEADRMVEKGH-----FAE 530
Cdd:cd17920 76 GIRAAALNSTLSPEEKREVLLRIKNgqykLLYVTPERLLsPDFLELLQRLPERKRLALIVVDEAHCVSQWGHdfrpdYLR 155
|
90 100
....*....|....*....|....*..
gi 226958385 531 LSQLLEMLNDSqynpsrQTLVFSATLT 557
Cdd:cd17920 156 LGRLRRALPGV------PILALTATAT 176
|
|
| |
