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Conserved domains on  [gi|226823271|ref|NP_001152837|]
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centrosomal protein of 97 kDa isoform 3 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 18-147 5.37e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 77.13  E-value: 5.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823271  18 VNWSGQGLQKLGANLPCEAdVHTLILDKNQIIKLENLEKCKQLIQLSVANNRLVRMMGVAKLTQLRVLNLPHNSIGCVEG 97
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKN-LKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823271  98 LKDLVHLE------------------------------WLNLAGNNLKTMEQVNSCTALQHLDLSDNNIPQIGDVSKLIS 147
Cdd:cd21340   86 LENLTNLEelhienqrlppgekltfdprslaalsnslrVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLS 165
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 18-147 5.37e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.13  E-value: 5.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823271  18 VNWSGQGLQKLGANLPCEAdVHTLILDKNQIIKLENLEKCKQLIQLSVANNRLVRMMGVAKLTQLRVLNLPHNSIGCVEG 97
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKN-LKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823271  98 LKDLVHLE------------------------------WLNLAGNNLKTMEQVNSCTALQHLDLSDNNIPQIGDVSKLIS 147
Cdd:cd21340   86 LENLTNLEelhienqrlppgekltfdprslaalsnslrVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLS 165
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
16-152 1.48e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 1.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823271  16 SVVNWSGQGLQKLGANLPCEADVHTLILDKNQIIKL-ENLEKCKQLIQLSVANNRLVRM-MGVAKLTQLRVLNLPHNSIG 93
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQIT 195

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226823271  94 CV-EGLKDLVHLEWLNLAGNNLKTM-EQVNSCTALQHLDLSDNNIPQIGDVSKLISLKMLS 152
Cdd:COG4886  196 DLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELD 256
LRR_8 pfam13855
Leucine rich repeat;
80-136 5.32e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 5.32e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226823271   80 TQLRVLNLPHNSIGCVEG--LKDLVHLEWLNLAGNNLKTMEQV--NSCTALQHLDLSDNNI 136
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 76-145 6.68e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 35.98  E-value: 6.68e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226823271  76 VAKLTQLRVLNLPHNSI--GCVEGLKDLVHLEWLNLAGNNL--KTMEQVNSCTALQHLDLSDNNI-----PQIGDVSKL 145
Cdd:PLN00113 184 LTNLTSLEFLTLASNQLvgQIPRELGQMKSLKWIYLGYNNLsgEIPYEIGGLTSLNHLDLVYNNLtgpipSSLGNLKNL 262
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 18-147 5.37e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.13  E-value: 5.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823271  18 VNWSGQGLQKLGANLPCEAdVHTLILDKNQIIKLENLEKCKQLIQLSVANNRLVRMMGVAKLTQLRVLNLPHNSIGCVEG 97
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKN-LKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823271  98 LKDLVHLE------------------------------WLNLAGNNLKTMEQVNSCTALQHLDLSDNNIPQIGDVSKLIS 147
Cdd:cd21340   86 LENLTNLEelhienqrlppgekltfdprslaalsnslrVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLS 165
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 41-134 1.10e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.97  E-value: 1.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823271  41 LILDKNQIIKLENLEKCKQLIQLSVANNRLVR----------MMGVAKltQLRVLNLPHNSIGCVEGLKDLVHLEWLNLA 110
Cdd:cd21340   73 LYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltfdprsLAALSN--SLRVLNISGNNIDSLEPLAPLRNLEQLDAS 150

                         90       100
                 ....*....|....*....|....*...
gi 226823271 111 GNNLKTMEQV----NSCTALQHLDLSDN 134
Cdd:cd21340  151 NNQISDLEELldllSSWPSLRELDLTGN 178
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
16-152 1.48e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 1.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823271  16 SVVNWSGQGLQKLGANLPCEADVHTLILDKNQIIKL-ENLEKCKQLIQLSVANNRLVRM-MGVAKLTQLRVLNLPHNSIG 93
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQIT 195

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226823271  94 CV-EGLKDLVHLEWLNLAGNNLKTM-EQVNSCTALQHLDLSDNNIPQIGDVSKLISLKMLS 152
Cdd:COG4886  196 DLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELD 256
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-136 1.20e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 1.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823271  40 TLILDKNQIIKL-ENLEKCKQLIQLSVANNRLVRM-MGVAKLTQLRVLNLPHNSIGCVEGLKDLVHLEWLNLAGNNLKTM 117
Cdd:COG4886  186 ELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL 265

                         90
                 ....*....|....*....
gi 226823271 118 EQVNSCTALQHLDLSDNNI 136
Cdd:COG4886  266 PPLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-151 1.71e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 1.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823271  40 TLILDKNQIIKL-ENLEKCKQLIQLSVANNRLVRM-MGVAKLTQLRVLNLPHNSIGCV-EGLKDLVHLEWLNLAGNNLKT 116
Cdd:COG4886  163 SLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTD 242

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 226823271 117 MEQVNSCTALQHLDLSDNNIPQIGDVSKLISLKML 151
Cdd:COG4886  243 LPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTL 277
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-118 1.53e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.55  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823271  40 TLILDKNQIIKL-ENLEKCKQLIQLSVANNRLVRMMGVAKLTQLRVLNLPHNSIGCVEGLKDLVHLEWLNLAGNNLKTME 118
Cdd:COG4886  209 ELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-152 4.46e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 4.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823271  35 EADVHTLILDKNQIIKLENLEKCKQLIQLSVANNRLVRMMGVAKLTQLRVLNLPHNsigcvEGLKDLVHLEWLNLAGNNL 114
Cdd:COG4886   51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQL 125

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 226823271 115 KTM-EQVNSCTALQHLDLSDNNIPQIGDV-SKLISLKMLS 152
Cdd:COG4886  126 TDLpEELANLTNLKELDLSNNQLTDLPEPlGNLTNLKSLD 165
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 58-136 2.70e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 2.70e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226823271  58 KQLIQLSVANNRLVRMMGVAKLTQLRVLNLPHNSIGCVEGLKDLVHLEWLNLAGNNLKTMEQVNSCTALQHLDLSDNNI 136
Cdd:cd21340    2 KRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80
LRR_8 pfam13855
Leucine rich repeat;
80-136 5.32e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 5.32e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226823271   80 TQLRVLNLPHNSIGCVEG--LKDLVHLEWLNLAGNNLKTMEQV--NSCTALQHLDLSDNNI 136
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 79-151 1.76e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 1.76e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226823271  79 LTQLRVLNLPHNSIGCVEGLKDLVHLEWLNLAGNNLKTMEQVNSCTALQHLDLSDNNIPQIGDVSKLISLKML 151
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKL 73
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 23-136 2.16e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.16  E-value: 2.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823271  23 QGLQKLGANLPCEADVHTLILDKNQI------IKLENLEKCKQLIQLSVANNRLVR--MMGVAKL----TQLRVLNLPHN 90
Cdd:COG5238  195 EGIEELAEALTQNTTVTTLWLKRNPIgdegaeILAEALKGNKSLTTLDLSNNQIGDegVIALAEAlknnTTVETLYLSGN 274

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 226823271  91 SIGC------VEGLKDLVHLEWLNLAGNNLKTMEQVNSCTALQH------LDLSDNNI 136
Cdd:COG5238  275 QIGAegaialAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGnktlhtLNLAYNGI 332
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 103-147 4.14e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 4.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 226823271  103 HLEWLNLAGNNLKTMEQVNSCTALQHLDLSDNNipQIGDVSKLIS 147
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNN--KITDLSDLAN 44
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-148 4.47e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.53  E-value: 4.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823271  39 HTLILDKNQIIKLENLEKCKQLIQLSVANNRLVRMMGVAKLTQLRVLNLPHNSIGCVEgLKDLVHLEWLNLAGNNLKTME 118
Cdd:COG4886  231 ETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK-LKELELLLGLNSLLLLLLLLN 309

                         90       100       110
                 ....*....|....*....|....*....|
gi 226823271 119 QVNSCTALQHLDLSDNNIPQIGDVSKLISL 148
Cdd:COG4886  310 LLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
LRR_8 pfam13855
Leucine rich repeat;
63-114 1.64e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 1.64e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 226823271   63 LSVANNRLVRMMGVA--KLTQLRVLNLPHNSIGCVEG--LKDLVHLEWLNLAGNNL 114
Cdd:pfam13855   6 LDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 23-149 3.36e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 36.69  E-value: 3.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226823271  23 QGLQKLGANLPCEADVHTLILDKNQI-----IKL-ENLEKCKQLIQLSVANNRLvRMMGVAKLTQ-------LRVLNLPH 89
Cdd:COG5238  251 EGVIALAEALKNNTTVETLYLSGNQIgaegaIALaKALQGNTTLTSLDLSVNRI-GDEGAIALAEglqgnktLHTLNLAY 329

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226823271  90 NSIG------CVEGLKDLVHLEWLNLAGNNLKT------MEQVNSCTALQHLDLSDNNIPQIGDVSKLISLK 149
Cdd:COG5238  330 NGIGaqgaiaLAKALQENTTLHSLDLSDNQIGDegaialAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQ 401
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 80-114 5.92e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 32.99  E-value: 5.92e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 226823271   80 TQLRVLNLPHNSIGCVEGLKDLVHLEWLNLAGNNL 114
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK 35
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 76-145 6.68e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 35.98  E-value: 6.68e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226823271  76 VAKLTQLRVLNLPHNSI--GCVEGLKDLVHLEWLNLAGNNL--KTMEQVNSCTALQHLDLSDNNI-----PQIGDVSKL 145
Cdd:PLN00113 184 LTNLTSLEFLTLASNQLvgQIPRELGQMKSLKWIYLGYNNLsgEIPYEIGGLTSLNHLDLVYNNLtgpipSSLGNLKNL 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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