|
Name |
Accession |
Description |
Interval |
E-value |
| squalene_cyclas |
TIGR01787 |
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ... |
76-710 |
0e+00 |
|
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.
Pssm-ID: 273809 [Multi-domain] Cd Length: 621 Bit Score: 978.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 76 GALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPaGYREEIVRYLR-----------HIEDKSTVFGTA 144
Cdd:TIGR01787 1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIADTPLP-GYREKIVRYLRhhqnedggwglHIGGKSTVFGTV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 145 LNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQ 224
Cdd:TIGR01787 80 LAYVALKILGMSPDDPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKSWCRCRM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 225 VYLPMSYCYAVRLSAAEDPlvqslRQELYVEDfASIDwlAQRNNVAPDELYTPHSWLLRVVYALLNL-YEHHHSAHLRQR 303
Cdd:TIGR01787 160 VYLPMSYCYGERLSAPIDP-----REELYVED-DSIR--AQRNNVAKEDLYTPHSWLLRALYGLLNLfYHPFLRKALRKR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 304 AVQKLYEHIVADDrftksiSIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTnGSQIWDTAFAIQ 383
Cdd:TIGR01787 232 ALQWLYEHIAADG------SIGPISKAMAMLALWFLDGPNSPAFQKHLQRIDDYLWLQLDGMKMQGT-GSQVWDTAFAIQ 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 384 ALLEAGGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRK-GGFSFSTLDCGW-IVSDCTAEALKAVLLLQEkcp 461
Cdd:TIGR01787 305 ALRESGDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAFSFLNCGYpDVDDTAVVALKAVLLLQE--- 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 462 hvTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFhkrfpEHR 541
Cdd:TIGR01787 382 --DEHVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQALGAF-----GHR 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 542 AAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADGGWGED 621
Cdd:TIGR01787 455 ADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRN---CPEVQKACDWLLSRQMPDGGWGED 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 622 FESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFN-KSCAISYTSYRNIF 700
Cdd:TIGR01787 532 CFSYEDPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRPDGDWPQEYITGVGFpKNFYLKYTNYRNIF 611
|
650
....*....|
gi 224177556 701 PIWALGRFSQ 710
Cdd:TIGR01787 612 PLWALGRYRQ 621
|
|
| SQCY_1 |
cd02892 |
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ... |
77-708 |
0e+00 |
|
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.
Pssm-ID: 239222 [Multi-domain] Cd Length: 634 Bit Score: 910.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 77 ALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLR-----------HIEDKSTVFGTAL 145
Cdd:cd02892 1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGIPIDPEHRKEIARYLRnhqnpdggwglHHEGPSTMFGTVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 146 NYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQV 225
Cdd:cd02892 81 NYVALRLLGVSPDDPHMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFWCWARTV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 226 YLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPdeLYTPHSWLLRVVYALLNLYEHHHSAHLRQRAV 305
Cdd:cd02892 161 YVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRNDLYD--YRPPWQRLFDALDRLLHWYEPLPPKPLRRKAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 306 QKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQAL 385
Cdd:cd02892 239 RKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPAFKRHLERIDDFLWLGPEGMKMCQTNGSQVWDTALAVQAL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 386 LEAGGHhrPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHvTE 465
Cdd:cd02892 319 LEAGLA--PEFDPALKKALDWLLESQILDNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALLRLQELPPF-GE 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 466 HIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRaAEI 545
Cdd:cd02892 396 KVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGLFGKLYPGHR-REI 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 546 RETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADGGWGEDFESC 625
Cdd:cd02892 475 DPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYEN---SPYIRKACDFLLSKQNPDGGWGESYLSY 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 626 EERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWAL 705
Cdd:cd02892 552 EDKSYAGGGRSTVVQTAWALLALMAAGEPDSEAVERGIKYLLNTQLPDGDWPQEEITGVGFPNFYIRYHNYRNYFPLWAL 631
|
...
gi 224177556 706 GRF 708
Cdd:cd02892 632 GRY 634
|
|
| PLN03012 |
PLN03012 |
Camelliol C synthase |
32-713 |
0e+00 |
|
Camelliol C synthase
Pssm-ID: 166653 [Multi-domain] Cd Length: 759 Bit Score: 570.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 32 GRQTWTYLQD-----ERAGREQTGLEAY---------------ALGLDTKNYFKDLPKA------HTAFEGALN----GM 81
Cdd:PLN03012 24 GRQTWEFDPDagspeELAAVEEARRIFYddrfhvkassdliwrMQFLKEKKFEQRIAPAkvedaeKITFEIATNalrkGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 82 TFYVGLQAEDGHW----TGDYGGPLFLLPGLLITCHVARIpLPAGYREEIVRYLR-----------HIEDKSTVFGTALN 146
Cdd:PLN03012 104 HFFSALQASDGHWpaenAGPLFFLPPLVFCLYITGHLDEI-FTQDHRKEILRYIYchqkedggwglHIEGHSTMFCTTLN 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 147 YVSLRILGVGPD---DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCR 223
Cdd:PLN03012 183 YICMRILGEGPDgghDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPIHPAKMWCYCR 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 224 QVYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAH---- 299
Cdd:PLN03012 263 LVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLIQDLIWDCLYIFAEPFLACwpfn 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 300 --LRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWyVDGPASTAFQEHVSRIPDYLWMGLDGMKMQgTNGSQIWD 377
Cdd:PLN03012 343 klLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACW-VEDPNGDHFKKHLLRISDYLWIAEDGMKMQ-SFGSQLWD 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 378 TAFAIQALLEAggHHRPEFSSCLQKAHEFLRLSQVPDNPP-DYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLL 456
Cdd:PLN03012 421 SGFALQALLAS--NLSNEIPDVLRRGHDFIKNSQVGENPSgDFKNMYRHISKGAWTFSDRDHGWQASDCTAEGFKCCLLF 498
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 457 QEKCPH-VTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHK 535
Cdd:PLN03012 499 SMIAPDiVGPKMDPEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIEHEYNECTSSAIQALILFKQ 578
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 536 RFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMAD 615
Cdd:PLN03012 579 LYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFND---CEAIRKGVHFLLAAQKDN 655
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 616 GGWGEDFESCEERRYLQSA--QSQIHNTCWAMMGLM----AVRHPdiEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSC 689
Cdd:PLN03012 656 GGWGESYLSCPKKIYIAQEgeISNLVQTAWALMGLIhagqAERDP--IPLHRAAKLIINSQLENGDFPQQEATGAFLKNC 733
|
730 740
....*....|....*....|....
gi 224177556 690 AISYTSYRNIFPIWALGRFSQLYP 713
Cdd:PLN03012 734 LLHYAAYRNIFPLWALAEYRARVP 757
|
|
| SqhC |
COG1657 |
Terpene cyclase SqhC [Lipid transport and metabolism]; |
71-712 |
0e+00 |
|
Terpene cyclase SqhC [Lipid transport and metabolism];
Pssm-ID: 441263 [Multi-domain] Cd Length: 644 Bit Score: 536.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 71 HTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLR-----------HIEDKST 139
Cdd:COG1657 18 RSLLDAAIAAAQALLLQQQDDGGWWGGELEADVTIAAEYILLHHFLGPDDEELEAKIARYLRrqqnddggwplYHGGPGD 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 140 VFGTALNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLW 219
Cdd:COG1657 98 LSTTVKAYFALKLLGDDPDAPHMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYKFS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 220 CHCRQVYLPMSYCYAVRLSAAEDPLVqsLRQELYVEDFASIDWLAQRNNVApdelyTPHSWLLRVVYALLNLYEHHHSAH 299
Cdd:COG1657 178 YWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVDYYFPAPRDR-----SPWSRFFLALDRLLRAYERLPPKP 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 300 LRQRAVQKLYEHIvaDDRFTKS---ISIGP-ISKTINMLvRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGtNGSQI 375
Cdd:COG1657 251 LRRRALRKAEDWI--LERLEGDgglGGIFPaMVNSLMAL-LALGYPPDHPVVRRALEALEKLLVETEDGARCQP-CVSPV 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 376 WDTAFAIQALLEAGghhRPEFSSCLQKAHEFLRLSQVPDnPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLL 455
Cdd:COG1657 327 WDTALAVQALQEAG---LPEDHPALERAADWLLSKQILV-KGDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVLMALLR 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 456 LQekcpHVTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEvFGdIMIDYTYVECTSAVMQALKyfhk 535
Cdd:COG1657 403 LR----LPDEPRYREAIERAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFAD-HG-ALLDPPTADVTARCLEMLG---- 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 536 rfpEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFLLSRQMAD 615
Cdd:COG1657 473 ---QLGLTEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGVDPDD----PAIRRAVAWLLSIQNAD 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 616 GGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNKSCAISYT 694
Cdd:COG1657 546 GGWGEDCRSYEDPRYVGLGPSTASQTAWALLALLAAGEADSPAVARGIAYLLSTQREDGSWDEEYFTGTgFPRVFYLRYH 625
|
650
....*....|....*...
gi 224177556 695 SYRNIFPIWALGRFSQLY 712
Cdd:COG1657 626 LYRQYFPLWALARYRNLR 643
|
|
| SQHop_cyclase_C |
pfam13243 |
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
373-708 |
9.06e-51 |
|
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.
Pssm-ID: 433057 [Multi-domain] Cd Length: 319 Bit Score: 179.84 E-value: 9.06e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 373 SQIWDTAFAIQALLEAGGhhrPEFSSCLQKAHEFLRLSQVPDnPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKA 452
Cdd:pfam13243 2 SPVWDTALALHALLEAGV---PADHPALVKAAQWLLDRQVLV-KGDWAVKRPDLEPGGWAFQFANDHYPDVDDTAVVVLA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 453 vlLLQEKCPHVTEhiPRERLCDAVAVLLNMRNPDGGFATYETKrggHLLELLN--PsevFGDI--MIDYTYVECTSAVMQ 528
Cdd:pfam13243 78 --LDRVRLPDERR--RDDAIARGIEWILGMQSKNGGWGAFDKD---NTKYYLNkiP---FADHgaLLDPPTADVTARVLE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 529 ALKYFHkrFPEHRAAEIRetltqGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFL 608
Cdd:pfam13243 148 MLGQLG--YPDDHPVAAR-----ALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNR----PYIRKAVDWL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 609 LSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNK 687
Cdd:pfam13243 217 KSRQNPDGGWGEDCESYKDPKLAGRGPSTASQTAWALLALMAAGEVDSPAVRRGIQYLLETQKPDGTWDEPYFTGTgFPR 296
|
330 340
....*....|....*....|.
gi 224177556 688 SCAISYTSYRNIFPIWALGRF 708
Cdd:pfam13243 297 VFYLKYHGYRNYFPLWALARY 317
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| squalene_cyclas |
TIGR01787 |
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ... |
76-710 |
0e+00 |
|
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.
Pssm-ID: 273809 [Multi-domain] Cd Length: 621 Bit Score: 978.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 76 GALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPaGYREEIVRYLR-----------HIEDKSTVFGTA 144
Cdd:TIGR01787 1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIADTPLP-GYREKIVRYLRhhqnedggwglHIGGKSTVFGTV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 145 LNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQ 224
Cdd:TIGR01787 80 LAYVALKILGMSPDDPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKSWCRCRM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 225 VYLPMSYCYAVRLSAAEDPlvqslRQELYVEDfASIDwlAQRNNVAPDELYTPHSWLLRVVYALLNL-YEHHHSAHLRQR 303
Cdd:TIGR01787 160 VYLPMSYCYGERLSAPIDP-----REELYVED-DSIR--AQRNNVAKEDLYTPHSWLLRALYGLLNLfYHPFLRKALRKR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 304 AVQKLYEHIVADDrftksiSIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTnGSQIWDTAFAIQ 383
Cdd:TIGR01787 232 ALQWLYEHIAADG------SIGPISKAMAMLALWFLDGPNSPAFQKHLQRIDDYLWLQLDGMKMQGT-GSQVWDTAFAIQ 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 384 ALLEAGGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRK-GGFSFSTLDCGW-IVSDCTAEALKAVLLLQEkcp 461
Cdd:TIGR01787 305 ALRESGDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAFSFLNCGYpDVDDTAVVALKAVLLLQE--- 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 462 hvTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFhkrfpEHR 541
Cdd:TIGR01787 382 --DEHVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQALGAF-----GHR 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 542 AAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADGGWGED 621
Cdd:TIGR01787 455 ADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRN---CPEVQKACDWLLSRQMPDGGWGED 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 622 FESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFN-KSCAISYTSYRNIF 700
Cdd:TIGR01787 532 CFSYEDPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRPDGDWPQEYITGVGFpKNFYLKYTNYRNIF 611
|
650
....*....|
gi 224177556 701 PIWALGRFSQ 710
Cdd:TIGR01787 612 PLWALGRYRQ 621
|
|
| SQCY_1 |
cd02892 |
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ... |
77-708 |
0e+00 |
|
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.
Pssm-ID: 239222 [Multi-domain] Cd Length: 634 Bit Score: 910.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 77 ALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLR-----------HIEDKSTVFGTAL 145
Cdd:cd02892 1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGIPIDPEHRKEIARYLRnhqnpdggwglHHEGPSTMFGTVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 146 NYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQV 225
Cdd:cd02892 81 NYVALRLLGVSPDDPHMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFWCWARTV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 226 YLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPdeLYTPHSWLLRVVYALLNLYEHHHSAHLRQRAV 305
Cdd:cd02892 161 YVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRNDLYD--YRPPWQRLFDALDRLLHWYEPLPPKPLRRKAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 306 QKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQAL 385
Cdd:cd02892 239 RKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPAFKRHLERIDDFLWLGPEGMKMCQTNGSQVWDTALAVQAL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 386 LEAGGHhrPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHvTE 465
Cdd:cd02892 319 LEAGLA--PEFDPALKKALDWLLESQILDNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALLRLQELPPF-GE 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 466 HIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRaAEI 545
Cdd:cd02892 396 KVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGLFGKLYPGHR-REI 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 546 RETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADGGWGEDFESC 625
Cdd:cd02892 475 DPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYEN---SPYIRKACDFLLSKQNPDGGWGESYLSY 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 626 EERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWAL 705
Cdd:cd02892 552 EDKSYAGGGRSTVVQTAWALLALMAAGEPDSEAVERGIKYLLNTQLPDGDWPQEEITGVGFPNFYIRYHNYRNYFPLWAL 631
|
...
gi 224177556 706 GRF 708
Cdd:cd02892 632 GRY 634
|
|
| osq_cycl |
TIGR03463 |
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella ... |
87-708 |
0e+00 |
|
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella aurantiaca which produces cycloartenol, and Gemmata obscuriglobus and Methylococcus capsulatus, which each produce the closely related sterol, lanosterol.
Pssm-ID: 274591 [Multi-domain] Cd Length: 634 Bit Score: 591.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 87 LQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLR-----------HIEDKSTVFGTALNYVSLRILGV 155
Cdd:TIGR03463 4 LQDSAGDWEGDMGGCQFIIAIAVAGLHVMGRPPDAEERAAIIAHFElhqladgawglDPEAPGQVFFSVLAYVALRLLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 156 GPDDPDLVRARNILH-KKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPMSYCYA 234
Cdd:TIGR03463 84 GKDDAGLARARAWFHaQPEGPKASGAWGKFILALLGLYEREGLNAVPPELFLLPESLPFHPSRFWCHCRLIYLGIAWLSG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 235 VRLSAAE-DPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLYEHIV 313
Cdd:TIGR03463 164 RGARAPEsDPLLAAIRQEIFAEGYEQVDFGAARERVAPTDLFTPISFVLKAANDLLAGYERLAGKALRARALDFAFEQIL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 314 ADDRFTKSISIGPISKTINMLVrWYVDGPASTAFQEHVSRIPDYLWMGLD-GMKMQGTNGSQIWDTAFAIQALLEAG--- 389
Cdd:TIGR03463 244 AEDEATHYICIGPINGLLNCLA-IFAHDPDGPDLAAHLEGLEAWFWEDDAeGLRMNGANSNALWDTAFAVQALAALGeld 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 390 GHHRpefsSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEK-CPHVTEHIP 468
Cdd:TIGR03463 323 EEAK----HALEEAAAFIDAAQMLADLADPQEAFRDPAKGGWCFSDGDHCWPISDCAAEALKALFALEELgDNRISEALG 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 469 RERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRAAEIRET 548
Cdd:TIGR03463 399 AARLQDAVEFILSMQNADGGFATYELQRGGKLLELLNPSDMFGQCMTDLSYVECTAACLGALAAWLKHHPDLPDAKIDAA 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 549 LTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFLLSRQMADGGWGEDFESCEER 628
Cdd:TIGR03463 479 IRKAEEFIRRRQLDDGSFMGFWGICFTYATFFGAKGLIAAGAEPAD----MALQAAAAFLLEKQRADGAWGEHVESCLEA 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 629 RYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRF 708
Cdd:TIGR03463 555 RWVEGKHGHAVMTAWALLALAAAGEAAHDAAERGIAWLCEQQGEDGGWPPEGIAGIFFGAAAIDYDAYLRIFPTWALARC 634
|
|
| PLN03012 |
PLN03012 |
Camelliol C synthase |
32-713 |
0e+00 |
|
Camelliol C synthase
Pssm-ID: 166653 [Multi-domain] Cd Length: 759 Bit Score: 570.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 32 GRQTWTYLQD-----ERAGREQTGLEAY---------------ALGLDTKNYFKDLPKA------HTAFEGALN----GM 81
Cdd:PLN03012 24 GRQTWEFDPDagspeELAAVEEARRIFYddrfhvkassdliwrMQFLKEKKFEQRIAPAkvedaeKITFEIATNalrkGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 82 TFYVGLQAEDGHW----TGDYGGPLFLLPGLLITCHVARIpLPAGYREEIVRYLR-----------HIEDKSTVFGTALN 146
Cdd:PLN03012 104 HFFSALQASDGHWpaenAGPLFFLPPLVFCLYITGHLDEI-FTQDHRKEILRYIYchqkedggwglHIEGHSTMFCTTLN 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 147 YVSLRILGVGPD---DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCR 223
Cdd:PLN03012 183 YICMRILGEGPDgghDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPIHPAKMWCYCR 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 224 QVYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAH---- 299
Cdd:PLN03012 263 LVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLIQDLIWDCLYIFAEPFLACwpfn 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 300 --LRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWyVDGPASTAFQEHVSRIPDYLWMGLDGMKMQgTNGSQIWD 377
Cdd:PLN03012 343 klLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACW-VEDPNGDHFKKHLLRISDYLWIAEDGMKMQ-SFGSQLWD 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 378 TAFAIQALLEAggHHRPEFSSCLQKAHEFLRLSQVPDNPP-DYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLL 456
Cdd:PLN03012 421 SGFALQALLAS--NLSNEIPDVLRRGHDFIKNSQVGENPSgDFKNMYRHISKGAWTFSDRDHGWQASDCTAEGFKCCLLF 498
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 457 QEKCPH-VTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHK 535
Cdd:PLN03012 499 SMIAPDiVGPKMDPEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIEHEYNECTSSAIQALILFKQ 578
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 536 RFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMAD 615
Cdd:PLN03012 579 LYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFND---CEAIRKGVHFLLAAQKDN 655
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 616 GGWGEDFESCEERRYLQSA--QSQIHNTCWAMMGLM----AVRHPdiEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSC 689
Cdd:PLN03012 656 GGWGESYLSCPKKIYIAQEgeISNLVQTAWALMGLIhagqAERDP--IPLHRAAKLIINSQLENGDFPQQEATGAFLKNC 733
|
730 740
....*....|....*....|....
gi 224177556 690 AISYTSYRNIFPIWALGRFSQLYP 713
Cdd:PLN03012 734 LLHYAAYRNIFPLWALAEYRARVP 757
|
|
| PLN02993 |
PLN02993 |
lupeol synthase |
80-708 |
0e+00 |
|
lupeol synthase
Pssm-ID: 215537 [Multi-domain] Cd Length: 763 Bit Score: 540.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 80 GMTFYVGLQAEDGHW----TGDYGGPLFLLPGLLITCHVARIpLPAGYREEIVRYLR-----------HIEDKSTVFGTA 144
Cdd:PLN02993 102 GVSFFSALQASDGHWpgeiTGPLFFLPPLVFCLYITGHLEEV-FDAEHRKEMLRHIYchqnedggwglHIESKSVMFCTV 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 145 LNYVSLRILGVGPD---DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCH 221
Cdd:PLN02993 181 LNYICLRMLGEGPNggrENACKRARQWILDHGGVTYIPSWGKFWLSILGIYDWSGTNPMPPEIWLLPSFLPIHLGKTLCY 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 222 CRQVYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAH-- 299
Cdd:PLN02993 261 TRMVYMPMSYLYGKRFVGPITPLIMLLREELHLQPYEEINWNKARRLCAKEDMYYPHPLVQDLIWDTLHNFVEPFLTRwp 340
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 300 ----LRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWyVDGPASTAFQEHVSRIPDYLWMGLDGMKMQgTNGSQI 375
Cdd:PLN02993 341 lnklVREKALQVAMKHIHYEDENSHYITIGCVEKVLCMLACW-IENPNGDHFKKHLARIPDYMWVAEDGMKMQ-SFGSQL 418
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 376 WDTAFAIQALLEAggHHRPEFSSCLQKAHEFLRLSQVPDNPP-DYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVL 454
Cdd:PLN02993 419 WDTGFAIQALLAS--DLSDETDDVLRRGHNYIKKSQVRENPSgDFKSMYRHISKGAWTLSDRDHGWQVSDCTAEALKCCM 496
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 455 LLQEKCPHVT-EHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYF 533
Cdd:PLN02993 497 LLSMMPADVVgQKIDPEQLYDSVNLLLSLQSENGGVTAWEPVRAYKWLELLNPTDFFANTMVEREYVECTSAVIQALVLF 576
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 534 HKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQM 613
Cdd:PLN02993 577 KQLYPDHRTKEIIKSIEKAVQFIESKQTPDGSWYGNWGICFIYATWFALGGLAAAGKTYND---CLAMRKGVHFLLTIQR 653
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 614 ADGGWGEDFESCEERRY--LQSAQSQIHNTCWAMMGLMAVRHP--DIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSC 689
Cdd:PLN02993 654 DDGGWGESYLSCPEQRYipLEGNRSNLVQTAWAMMGLIHAGQAerDLIPLHRAAKLIITSQLENGDFPQQEILGAFMNTC 733
|
650
....*....|....*....
gi 224177556 690 AISYTSYRNIFPIWALGRF 708
Cdd:PLN02993 734 MLHYATYRNTFPLWALAEY 752
|
|
| SqhC |
COG1657 |
Terpene cyclase SqhC [Lipid transport and metabolism]; |
71-712 |
0e+00 |
|
Terpene cyclase SqhC [Lipid transport and metabolism];
Pssm-ID: 441263 [Multi-domain] Cd Length: 644 Bit Score: 536.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 71 HTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLR-----------HIEDKST 139
Cdd:COG1657 18 RSLLDAAIAAAQALLLQQQDDGGWWGGELEADVTIAAEYILLHHFLGPDDEELEAKIARYLRrqqnddggwplYHGGPGD 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 140 VFGTALNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLW 219
Cdd:COG1657 98 LSTTVKAYFALKLLGDDPDAPHMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYKFS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 220 CHCRQVYLPMSYCYAVRLSAAEDPLVqsLRQELYVEDFASIDWLAQRNNVApdelyTPHSWLLRVVYALLNLYEHHHSAH 299
Cdd:COG1657 178 YWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVDYYFPAPRDR-----SPWSRFFLALDRLLRAYERLPPKP 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 300 LRQRAVQKLYEHIvaDDRFTKS---ISIGP-ISKTINMLvRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGtNGSQI 375
Cdd:COG1657 251 LRRRALRKAEDWI--LERLEGDgglGGIFPaMVNSLMAL-LALGYPPDHPVVRRALEALEKLLVETEDGARCQP-CVSPV 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 376 WDTAFAIQALLEAGghhRPEFSSCLQKAHEFLRLSQVPDnPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLL 455
Cdd:COG1657 327 WDTALAVQALQEAG---LPEDHPALERAADWLLSKQILV-KGDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVLMALLR 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 456 LQekcpHVTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEvFGdIMIDYTYVECTSAVMQALKyfhk 535
Cdd:COG1657 403 LR----LPDEPRYREAIERAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFAD-HG-ALLDPPTADVTARCLEMLG---- 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 536 rfpEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFLLSRQMAD 615
Cdd:COG1657 473 ---QLGLTEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGVDPDD----PAIRRAVAWLLSIQNAD 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 616 GGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNKSCAISYT 694
Cdd:COG1657 546 GGWGEDCRSYEDPRYVGLGPSTASQTAWALLALLAAGEADSPAVARGIAYLLSTQREDGSWDEEYFTGTgFPRVFYLRYH 625
|
650
....*....|....*...
gi 224177556 695 SYRNIFPIWALGRFSQLY 712
Cdd:COG1657 626 LYRQYFPLWALARYRNLR 643
|
|
| SQCY |
cd02889 |
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ... |
373-708 |
9.03e-175 |
|
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.
Pssm-ID: 239219 [Multi-domain] Cd Length: 348 Bit Score: 503.29 E-value: 9.03e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 373 SQIWDTAFAIQALLEAGGHhrPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKA 452
Cdd:cd02889 23 SQVWDTALALQALLEAGLA--PEFDPALKKALEWLLKSQIRDNPDDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 453 VLLLQEKCPHvTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELlnPSEVFGDIMIDYTYVECTSAVMQALKY 532
Cdd:cd02889 101 LLRLQKKPPD-GKKVSRERLYDAVDWLLSMQNSNGGFAAFEPDNTYKYLEL--IPEVDGDIMIDPPYVECTGSVLEALGL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 533 FHKRFPEHRAaEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRdgtaCAEVSRACDFLLSRQ 612
Cdd:cd02889 178 FGKLYPEHRR-EIDPAIRRAVKYLEREQEPDGSWYGRWGVCFIYGTWFALEALAAAGEDEN----SPYVRKACDWLLSKQ 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 613 MADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAIS 692
Cdd:cd02889 253 NPDGGWGESYESYEDPSYAGGGRSTVVQTAWALLALMAAGEPDSEAVKRGVKYLLNTQQEDGDWPQEEITGVFFKNFYIR 332
|
330
....*....|....*.
gi 224177556 693 YTSYRNIFPIWALGRF 708
Cdd:cd02889 333 YHNYRNYFPLWALGRY 348
|
|
| hopene_cyclase |
TIGR01507 |
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) ... |
83-711 |
2.34e-57 |
|
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products. [Fatty acid and phospholipid metabolism, Other]
Pssm-ID: 273661 [Multi-domain] Cd Length: 635 Bit Score: 206.28 E-value: 2.34e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 83 FYVGLQAEDGHWTGDYGGPLFLLPGLLITCH----VARIPLpagyrEEIVRYLRHIE-----------DKSTVFGTALNY 147
Cdd:TIGR01507 24 YLLSCQKDEGYWWGELESNVTIEAEYVLLCHildrVDRDRM-----EKIRNYLLHEQredgtwalypgGPGDLSTTVEAY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 148 VSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYL 227
Cdd:TIGR01507 99 VALKYIGMSRDEPPMQKALRFIQSQGGIESSRVFTRMWLALVGEYPWRGVPMVPPEIMLLPKRFPFNIYEFSSWARATVV 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 228 PMSYCYAVRLSAaedPLVQSLR-QELYVEDfasidwlaqrnnVAPDELYTPHS---W-LLRVVYALLNLYEHHHSAHLRQ 302
Cdd:TIGR01507 179 PLSIVCSRKPVF---PLPERARvPELYETD------------VPKPRRRGAKGgtgWgIFDALDRALHGYEKLSVHPFRR 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 303 RAVQKLYEHIVAddRFTKSISIGPISKT-INMLVRWYVDG-PASTAF-QEHVSRIPDYLWMGLDGMKMQGTNgSQIWDTA 379
Cdd:TIGR01507 244 AAEIRALDWLLE--RQAGDGSWGGIQPAmFNALIALKILGmTQHDAFiKLGWEGIDLYGVELDDSWMFQACV-SPVWDTA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 380 FAIQALLEAGghhRPEFSSCLQKAHEFLRLSQVpDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEK 459
Cdd:TIGR01507 321 LAVLALREAG---LPADHDALVKAGEWLLDKQI-TVPGDWAVKRPNLEPGGWAFQFDNVYYPDVDDTAVVVWALNGLRLP 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 460 cphvTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNpsevFGDI--MIDYTYVECTSAVMQALKYFHKRF 537
Cdd:TIGR01507 397 ----DERRRRDAMTKAFRWIAGMQSSNGGWGAFDVDNTSDLLNHIP----FCDFgaVTDPPTADVTARVLECLGSFGYDD 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 538 PehraaeiRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFLLSRQMADGG 617
Cdd:TIGR01507 469 A-------WPVIERAVEYLKREQEPDGSWFGRWGVNYLYGTGAVLSALKAVGIDTRE----PYIQKALAWLESHQNPDGG 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 618 WGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNKSCAISYTSY 696
Cdd:TIGR01507 538 WGEDCRSYEDPAYAGKGASTASQTAWALIALIAAGRAESEAARRGVQYLVETQRPDGGWDEPYYTGTgFPGDFYLGYHMY 617
|
650
....*....|....*
gi 224177556 697 RNIFPIWALGRFSQL 711
Cdd:TIGR01507 618 RHVFPLLALARYKQA 632
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
363-708 |
2.79e-56 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 194.31 E-value: 2.79e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 363 DGMKMQGTNGSQIWDTAFAIQALLEAGGH--HRPEFSSCLQKAHEFLRLSQVPDnppdyqkyyrqmrkGGFSFSTLDcGW 440
Cdd:cd00688 15 DGHWYQSLCGEQTWSTAWPLLALLLLLAAtgIRDKADENIEKGIQRLLSYQLSD--------------GGFSGWGGN-DY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 441 IVSDCTAEALKAVLLLQEkcphvTEHIPRERLCDAVAVLLNMRNPDGGFATYEtkrgghllellnpsEVFGDIMIDYTYV 520
Cdd:cd00688 80 PSLWLTAYALKALLLAGD-----YIAVDRIDLARALNWLLSLQNEDGGFREDG--------------PGNHRIGGDESDV 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 521 ECTSAVMQALKYFHKRFPehraaeiRETLTQGLEFCRRQQRADGSWeGSWGVCFTYGTWFGLEAFACMGQTYRDgtacaE 600
Cdd:cd00688 141 RLTAYALIALALLGKLDP-------DPLIEKALDYLLSCQNYDGGF-GPGGESHGYGTACAAAALALLGDLDSP-----D 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 601 VSRACDFLLSRQMADGGWGedfesceERRYLQSAQSQIHNTCWAMMGLMA-VRHPDIEAQERGVRCLLEKQLPNGDWPQE 679
Cdd:cd00688 208 AKKALRWLLSRQRPDGGWG-------EGRDRTNKLSDSCYTEWAAYALLAlGKLGDLEDAEKLVKWLLSQQNEDGGFSSK 280
|
330 340
....*....|....*....|....*....
gi 224177556 680 NIagvfnkscaISYTSYRNIFPIWALGRF 708
Cdd:cd00688 281 PG---------KSYDTQHTVFALLALSLY 300
|
|
| SQHop_cyclase_C |
pfam13243 |
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
373-708 |
9.06e-51 |
|
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.
Pssm-ID: 433057 [Multi-domain] Cd Length: 319 Bit Score: 179.84 E-value: 9.06e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 373 SQIWDTAFAIQALLEAGGhhrPEFSSCLQKAHEFLRLSQVPDnPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKA 452
Cdd:pfam13243 2 SPVWDTALALHALLEAGV---PADHPALVKAAQWLLDRQVLV-KGDWAVKRPDLEPGGWAFQFANDHYPDVDDTAVVVLA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 453 vlLLQEKCPHVTEhiPRERLCDAVAVLLNMRNPDGGFATYETKrggHLLELLN--PsevFGDI--MIDYTYVECTSAVMQ 528
Cdd:pfam13243 78 --LDRVRLPDERR--RDDAIARGIEWILGMQSKNGGWGAFDKD---NTKYYLNkiP---FADHgaLLDPPTADVTARVLE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 529 ALKYFHkrFPEHRAAEIRetltqGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFL 608
Cdd:pfam13243 148 MLGQLG--YPDDHPVAAR-----ALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNR----PYIRKAVDWL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 609 LSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGV-FNK 687
Cdd:pfam13243 217 KSRQNPDGGWGEDCESYKDPKLAGRGPSTASQTAWALLALMAAGEVDSPAVRRGIQYLLETQKPDGTWDEPYFTGTgFPR 296
|
330 340
....*....|....*....|.
gi 224177556 688 SCAISYTSYRNIFPIWALGRF 708
Cdd:pfam13243 297 VFYLKYHGYRNYFPLWALARY 317
|
|
| SQHop_cyclase_N |
pfam13249 |
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
86-314 |
1.27e-30 |
|
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.
Pssm-ID: 433061 [Multi-domain] Cd Length: 290 Bit Score: 121.82 E-value: 1.27e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 86 GLQAEDGHWTGD----------YggplfllpgllITCHVARIPLPAGYREEIVRYLRHI-----------EDKSTVFGTA 144
Cdd:pfam13249 10 SLQHPDGHWVGEleanvtitaeY-----------ILLRHFLGPDDPELEAKIARYLRSQqredggwplfhGGPGDLSTTV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 145 LNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQ 224
Cdd:pfam13249 79 EAYFALKLLGDSPDAPHMVRAREFILARGGAAKANVFTRIWLALFGQYPWRGVPSMPPEIMLLPRWFPFNIYKFSSWART 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 225 VYLPMSYCYAVRLSAAEDPlvQSLRQELYVEDFASIDWlaqrnnvaPDELYTPHSW--LLRVVYALLNLYEHHHSAHLRQ 302
Cdd:pfam13249 159 TIVPLLILSALKPVAPLPP--GIGLDELFVEPPENVRY--------YPRPHRLFSWtnLFLGLDRVLKLYERLPPKPLRR 228
|
250
....*....|..
gi 224177556 303 RAVQKLYEHIVA 314
Cdd:pfam13249 229 RALRKAEEWILE 240
|
|
| squa_tetra_cyc |
TIGR04277 |
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, ... |
143-708 |
5.49e-16 |
|
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, occurs a small number of eukaryotes, some of them anaerobic. The pathway can occur under anaerobic conditions, and the product is thought to replace sterols, letting organisms with this compound build membrane suitable for performing phagocytosis.
Pssm-ID: 212000 [Multi-domain] Cd Length: 624 Bit Score: 81.99 E-value: 5.49e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 143 TALNYVSLRILGVGPD-DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLntLFPEMWLFPDWAPAHPSTLWCH 221
Cdd:TIGR04277 103 TIFNYWYLKAIGIDIHiDAALKKAQEWIKANGGIEAAQTMTKFKLAAFGQYPWEDL--FKIPLFIFKKKGIFKPLYIKDI 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 222 CRQ-VYLPMSYCYAVRLSAAEDPLVQSLRQELYvedfasIDWLAQRNNVAPDELYT--PHSWLLRVVYALLNLYEHHHSa 298
Cdd:TIGR04277 181 TAQwVYPHLTALAYLQNQRIIFNVAVADIRELW------INKAKKGIKHQKKERPSffIDNDLLILMDEIFKLKQPLGS- 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 299 hLRQRAVQKLYEHIVADDrFTksisigpiSKTINMlvrwyvdgpastafqeHVSRIPDYLWMGLDGMKM------QGTNG 372
Cdd:TIGR04277 254 -FGAYTISTLLSLLAFKD-FQ--------GKHPHK----------------HKNEIQDALEDGLDFVEFnyfnfrEAYHG 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 373 S----QIWDTAFAIQALLEAGGHH---RPEFSSCLQKAHEflrlsqvPDNPPDYQKYYrqmrkgGFSFSTLDCGwivsdc 445
Cdd:TIGR04277 308 SlddgRWWDTILISWAMLESGEDKekiFPIVENMLKEGLQ-------PKGGIEYGYDF------EYAPDADDTG------ 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 446 taealkavLLLQEKCPHVTEHipRERLCDAVAVLLNMRNPDGGFATYET-KRGGHLL--------ELLNPSEVFgdimiD 516
Cdd:TIGR04277 369 --------LLLQVLSYYGEAF--ADAIDEGAEFLFSMQNDDGGFPAFDKgKMEDNLLfkfafkiaGIADSAEIF-----D 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 517 YTYVECTSAVMQALKYFHKRfPEHraaeirETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDGT 596
Cdd:TIGR04277 434 PSCPDITAHILEGLGEFGDQ-ANH------DQIQKMIKYFMDTQEKFGSWEARWGINYIMAAGAVLPALAKMNYDLNEGW 506
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 597 acaeVSRACDFLLSRQMADGGWGEDFESCEE-RRYLQSAQSQIHNTCWAMMGLMAVR-HPDI--EAQERGVRCLLEK-QL 671
Cdd:TIGR04277 507 ----AKNAINWLLNKQNADGGFGECTLSYNDpEKWNGIGKSTVTQTSWGLLALLAVEdHNDQikEAADKAAQYLLDQfKR 582
|
570 580 590
....*....|....*....|....*....|....*...
gi 224177556 672 PNGDWPQENIAGVFNKSCA-ISYTSYRNIFPIWALGRF 708
Cdd:TIGR04277 583 DDGEFKDHSTIGTGHRGLLyLQYPSYAQSFPLIALGRF 620
|
|
| CAL1 |
COG5029 |
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ... |
479-674 |
4.82e-08 |
|
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];
Pssm-ID: 444045 [Multi-domain] Cd Length: 259 Bit Score: 54.71 E-value: 4.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 479 LLNMRNPDGGFATYETkrgghllellnPSEVFgdimidYTYVECTSAVMQALKYFHkrfpEHRAAEIRETLtqglefcrr 558
Cdd:COG5029 28 LRASQNPDGGFAGRSG-----------PSDLY------STYYAVRTLALLGESPKW----RDRVADLLSSL--------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 559 qQRADGSW----EGSWGvcFTYGTWFGLEAFACMGQTYRDgtacaeVSRACDFLLSRQMADGGWGEDFesceerrylqSA 634
Cdd:COG5029 78 -RVEDGGFakapEGGAG--STYHTYLATLLAELLGRPPPD------PDRLVRFLISQQNDDGGFEISP----------GR 138
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 224177556 635 QSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNG 674
Cdd:COG5029 139 RSDTNPTAAAIGALRALGALDDPIETKVIRFLRDVQSPEG 178
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
553-589 |
3.16e-07 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 47.12 E-value: 3.16e-07
10 20 30
....*....|....*....|....*....|....*...
gi 224177556 553 LEFCRRQQRADGSWEGSWGVC-FTYGTWFGLEAFACMG 589
Cdd:pfam00432 7 VDYLLSCQNEDGGFGGRPGGEsDTYYTYCALAALALLG 44
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
601-647 |
1.51e-05 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 42.50 E-value: 1.51e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 224177556 601 VSRACDFLLSRQMADGGWGEDFESCeerryLQSAQSQIHNTCWAMMG 647
Cdd:pfam00432 3 KEKLVDYLLSCQNEDGGFGGRPGGE-----SDTYYTYCALAALALLG 44
|
|
| AF1543 |
COG1689 |
Class II terpene cyclase family protein AF1543 [General function prediction only]; |
400-649 |
3.37e-03 |
|
Class II terpene cyclase family protein AF1543 [General function prediction only];
Pssm-ID: 441295 [Multi-domain] Cd Length: 272 Bit Score: 40.09 E-value: 3.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 400 LQKAHEFLRLSQVPDnppdyqkyyrqmrkGGFSF-----STLdcgwivSDcTAEALKAVLLLQEKCPHVTEHIprerlcd 474
Cdd:COG1689 8 LARTIEYVLKRQNED--------------GGFCAypglpSTL------AD-TYYAVRILKLLGEEVPNRDKTI------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 475 avAVLLNMRNPDGG-FATYETKRGGHLLELLnpsevfGDIMIDYtyvectsavMQALKYFHKRFPEHRAAE---IRET-- 548
Cdd:COG1689 60 --EFLESCQDEEGGgFALYTTSYGLMALALL------GIDPPDE---------QEALEYLSDALPTKFAGGasdLEETyl 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 549 LTQGLE--------------FCRRQQRADGSWEGSWGVcfTYGTWFGLEAFACMGQTYRDGtacaevSRACDFLLSRQMA 614
Cdd:COG1689 123 AVALLEalgaseperekireFLLSLRRPDGGFGGKKPN--LEDTYWALAALRRLGRDLPPA------DRVIAFILACQNE 194
|
250 260 270
....*....|....*....|....*....|....*
gi 224177556 615 DGGWGedfesceerrYLQSAQSQIHNTCWAMMGLM 649
Cdd:COG1689 195 DGGFS----------KTPGSYSDLEATYYALRALK 219
|
|
| AF1543 |
COG1689 |
Class II terpene cyclase family protein AF1543 [General function prediction only]; |
377-565 |
5.44e-03 |
|
Class II terpene cyclase family protein AF1543 [General function prediction only];
Pssm-ID: 441295 [Multi-domain] Cd Length: 272 Bit Score: 39.32 E-value: 5.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 377 DTAFAIQALLEAGG-------------HHRPEFSSCLQKAHEFLR---LSQVPDNPPDYQK---YYR-----QMRKGGFS 432
Cdd:COG1689 37 DTYYAVRILKLLGEevpnrdktiefleSCQDEEGGGFALYTTSYGlmaLALLGIDPPDEQEaleYLSdalptKFAGGASD 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224177556 433 FSTLDCgwivsdcTAEALKAVLLLQEKCPhvtehiprerlcDAVAVLLNMRNPDGGFA-----TYETkrgGHLLELL--- 504
Cdd:COG1689 117 LEETYL-------AVALLEALGASEPERE------------KIREFLLSLRRPDGGFGgkkpnLEDT---YWALAALrrl 174
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 224177556 505 -----NPSEV-------------FGDIMIDYTYVECTSAVMQALKYFHKRFPEHRAAeiretltqgLEFCRRQQRADGS 565
Cdd:COG1689 175 grdlpPADRViafilacqnedggFSKTPGSYSDLEATYYALRALKLLGEPPKNVDKL---------LEFIASCQNSDGG 244
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| SQCY |
cd02889 |
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ... |
603-676 |
7.34e-03 |
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Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.
Pssm-ID: 239219 [Multi-domain] Cd Length: 348 Bit Score: 39.13 E-value: 7.34e-03
10 20 30 40 50 60 70
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gi 224177556 603 RACDFLLSRQMADGGWGEDFesceerrylqsaqSQIHNTCWAMMGLMA--VRHPDIEAQERGVRCLLEKQLP-NGDW 676
Cdd:cd02889 3 RALDFLLSLQAPDGHWPGEY-------------SQVWDTALALQALLEagLAPEFDPALKKALEWLLKSQIRdNPDD 66
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