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Conserved domains on  [gi|224451032|ref|NP_001138776|]
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IQ domain-containing protein N isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 276-558 6.76e-08

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 57.23  E-value: 6.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   276 GDSVKTKRVS----ARTNKARAPETPLSRRYDQAvTRPSRAQTQGPVKAETPKAPFQICPGPMITKTllqTYPVVSVTLP 351
Cdd:pfam05109  465 GPTVSTADVTsptpAGTTSGASPVTPSPSPRDNG-TESKAPDMTSPTSAVTTPTPNATSPTPAVTTP---TPNATSPTLG 540

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   352 QTYPASTMTT-TPPKTSPVPKVTiikTPAQMYPGPTVTKTAPH---TCPMPTMTKIQVHPTASRTGTPRQTCPAT----- 422
Cdd:pfam05109  541 KTSPTSAVTTpTPNATSPTPAVT---TPTPNATIPTLGKTSPTsavTTPTPNATSPTVGETSPQANTTNHTLGGTsstpv 617

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   423 ITAKNRPQVSLLASIMKSLPQVCPGpAMAKTPPQMHPVTTPAKN-------PLQTCLSATMSKTSSQRSPVGVTKPSPQT 495
Cdd:pfam05109  618 VTSPPKNATSAVTTGQHNITSSSTS-SMSLRPSSISETLSPSTSdnstshmPLLTSAHPTGGENITQVTPASTSTHHVST 696

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 224451032   496 RLPAMITKTPAQlrsvatilktlcLASPTVANVKAPP-QVAVAAGTPNTSGSIHENPPKAKATV 558
Cdd:pfam05109  697 SSPAPRPGTTSQ------------ASGPGNSSTSTKPgEVNVTKGTPPKNATSPQAPSGQKTAV 748
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 351-862 1.20e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 1.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  351 PQTYPASTMTTTPPKTSPVPKvtiiktPAQMYPGPTVTKTA--PHTCPMPTMTKIQVHPTASRTGTPRQTCPATITAKNR 428
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSVPPPR------PAPRPSEPAVTSRArrPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  429 PQvsllASIMKSLPQVCPGPAMAKTPPQMHPVTTPAknPLQTCLSatmSKTSSQRSPVGVTKPSPQTRLPAMitktPAQL 508
Cdd:PHA03247 2626 PP----PPSPSPAANEPDPHPPPTVPPPERPRDDPA--PGRVSRP---RRARRLGRAAQASSPPQRPRRRAA----RPTV 2692

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  509 RSVATILKtlclaSPTVANVKAPPQVAVAAGTPNTSGsihenPPKAKATVNVKQAAKVVKASSPSYLAEGKIRCLAQPHP 588
Cdd:PHA03247 2693 GSLTSLAD-----PPPPPPTPEPAPHALVSATPLPPG-----PAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT 2762

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  589 GTGVPRAAAElpleaekiktgtqkqaktdmAFKTSVAVEMAGAPSWTKVAEEGDKPPHVYVPVDMAVTLPRGQLAAPLTN 668
Cdd:PHA03247 2763 TAGPPAPAPP--------------------AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAA 2822

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  669 ASSQRHPPCLSQRPLAAPLTKASSQGHLPTELTKTPS--LAHLDTCLSKMHSQTHLATGAVKVQSQAPLAtclTKTQSRG 746
Cdd:PHA03247 2823 SPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGgdVRRRPPSRSPAAKPAAPARPPVRRLARPAVS---RSTESFA 2899

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  747 QPITDITTCLIPAHQAADLSSNTHSQvlltgsKVSNHACQRLGGLSAPPWAKPEDRQTQPQPHGHVPGKTTqGGPCPAAC 826
Cdd:PHA03247 2900 LPPDQPERPPQPQAPPPPQPQPQPPP------PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWL-GALVPGRV 2972

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 224451032  827 EVQGMLVPPMAP------------TGHSTCNVESWGDNGATRAQPSMP 862
Cdd:PHA03247 2973 AVPRFRVPQPAPsreapasstpplTGHSLSRVSSWASSLALHEETDPP 3020
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 97-131 7.84e-05

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


:

Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 40.99  E-value: 7.84e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224451032   97 DEMDMMHaRAATLIQANWRGYWLRQKLISQMMAAK 131
Cdd:cd23767     3 EELQRMN-RAATLIQALWRGYKVRKELKKKKKKGK 36
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 1137-1158 9.71e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


:

Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 37.91  E-value: 9.71e-04
                          10        20
                  ....*....|....*....|..
gi 224451032 1137 HRGAMVIQATWRGYRVRRNLAH 1158
Cdd:cd23767     9 NRAATLIQALWRGYKVRKELKK 30
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
 1116-1134 4.97e-03

IQ calmodulin-binding motif; Calmodulin-binding motif.


:

Pssm-ID: 459869  Cd Length: 21  Bit Score: 35.76  E-value: 4.97e-03
                           10
                   ....*....|....*....
gi 224451032  1116 AVITIQAGVRGYLARRRIR 1134
Cdd:pfam00612    3 AAIKIQAAWRGYLARKRYK 21
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 1161-1181 9.17e-03

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


:

Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 35.21  E-value: 9.17e-03
                          10        20
                  ....*....|....*....|.
gi 224451032 1161 RATTTIQSAWRGYSTRRDQAR 1181
Cdd:cd23767    10 RAATLIQALWRGYKVRKELKK 30
 
Name Accession Description Interval E-value
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 276-558 6.76e-08

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 57.23  E-value: 6.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   276 GDSVKTKRVS----ARTNKARAPETPLSRRYDQAvTRPSRAQTQGPVKAETPKAPFQICPGPMITKTllqTYPVVSVTLP 351
Cdd:pfam05109  465 GPTVSTADVTsptpAGTTSGASPVTPSPSPRDNG-TESKAPDMTSPTSAVTTPTPNATSPTPAVTTP---TPNATSPTLG 540

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   352 QTYPASTMTT-TPPKTSPVPKVTiikTPAQMYPGPTVTKTAPH---TCPMPTMTKIQVHPTASRTGTPRQTCPAT----- 422
Cdd:pfam05109  541 KTSPTSAVTTpTPNATSPTPAVT---TPTPNATIPTLGKTSPTsavTTPTPNATSPTVGETSPQANTTNHTLGGTsstpv 617

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   423 ITAKNRPQVSLLASIMKSLPQVCPGpAMAKTPPQMHPVTTPAKN-------PLQTCLSATMSKTSSQRSPVGVTKPSPQT 495
Cdd:pfam05109  618 VTSPPKNATSAVTTGQHNITSSSTS-SMSLRPSSISETLSPSTSdnstshmPLLTSAHPTGGENITQVTPASTSTHHVST 696

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 224451032   496 RLPAMITKTPAQlrsvatilktlcLASPTVANVKAPP-QVAVAAGTPNTSGSIHENPPKAKATV 558
Cdd:pfam05109  697 SSPAPRPGTTSQ------------ASGPGNSSTSTKPgEVNVTKGTPPKNATSPQAPSGQKTAV 748
PHA03247 PHA03247
large tegument protein UL36; Provisional
 205-604 7.86e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 7.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  205 PQSSPLLQPPAAQGTPEPCVQGPHAARVRGLAFLPHQTVTIRFPCPVSLDAKCQPCLLTRTIRSTCLVHIEGDSVKTKR- 283
Cdd:PHA03247 2604 DRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRp 2683

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  284 --------VSARTNKARAPETPLSRRYDQAVTRPSRAQTQGPVKAETPKAPFQICPGPMITKTLLQT--------YPVVS 347
Cdd:PHA03247 2684 rrraarptVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATpggparpaRPPTT 2763

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  348 VTLPQTYPASTMTTTPPKTSPVPKVTIIKTPAQMYPGPTVTKTAPHTCPMPTMTKiqvhPTASRTGTPRQTCPATITAKN 427
Cdd:PHA03247 2764 AGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL----PPAASPAGPLPPPTSAQPTAP 2839

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  428 RPQVSLLASIMKSLPQVCPGPAMAKTPPQMHPVTTPAKNPLQTCLSATMSKTSSQRSPVGVTKPSPQtRLPAMITKTPAQ 507
Cdd:PHA03247 2840 PPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPE-RPPQPQAPPPPQ 2918

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  508 LRSVATILKTLCLASPTVANVKAPPQ-VAVAAGTPNTSGSIHENPPKAKATVNVKQAAKVVKASSPSYLAEGKIRCLAQP 586
Cdd:PHA03247 2919 PQPQPPPPPQPQPPPPPPPRPQPPLApTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTG 2998

                         410
                  ....*....|....*...
gi 224451032  587 HPGTGVPRAAAELPLEAE 604
Cdd:PHA03247 2999 HSLSRVSSWASSLALHEE 3016
PHA03247 PHA03247
large tegument protein UL36; Provisional
 351-862 1.20e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 1.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  351 PQTYPASTMTTTPPKTSPVPKvtiiktPAQMYPGPTVTKTA--PHTCPMPTMTKIQVHPTASRTGTPRQTCPATITAKNR 428
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSVPPPR------PAPRPSEPAVTSRArrPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  429 PQvsllASIMKSLPQVCPGPAMAKTPPQMHPVTTPAknPLQTCLSatmSKTSSQRSPVGVTKPSPQTRLPAMitktPAQL 508
Cdd:PHA03247 2626 PP----PPSPSPAANEPDPHPPPTVPPPERPRDDPA--PGRVSRP---RRARRLGRAAQASSPPQRPRRRAA----RPTV 2692

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  509 RSVATILKtlclaSPTVANVKAPPQVAVAAGTPNTSGsihenPPKAKATVNVKQAAKVVKASSPSYLAEGKIRCLAQPHP 588
Cdd:PHA03247 2693 GSLTSLAD-----PPPPPPTPEPAPHALVSATPLPPG-----PAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT 2762

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  589 GTGVPRAAAElpleaekiktgtqkqaktdmAFKTSVAVEMAGAPSWTKVAEEGDKPPHVYVPVDMAVTLPRGQLAAPLTN 668
Cdd:PHA03247 2763 TAGPPAPAPP--------------------AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAA 2822

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  669 ASSQRHPPCLSQRPLAAPLTKASSQGHLPTELTKTPS--LAHLDTCLSKMHSQTHLATGAVKVQSQAPLAtclTKTQSRG 746
Cdd:PHA03247 2823 SPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGgdVRRRPPSRSPAAKPAAPARPPVRRLARPAVS---RSTESFA 2899

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  747 QPITDITTCLIPAHQAADLSSNTHSQvlltgsKVSNHACQRLGGLSAPPWAKPEDRQTQPQPHGHVPGKTTqGGPCPAAC 826
Cdd:PHA03247 2900 LPPDQPERPPQPQAPPPPQPQPQPPP------PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWL-GALVPGRV 2972

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 224451032  827 EVQGMLVPPMAP------------TGHSTCNVESWGDNGATRAQPSMP 862
Cdd:PHA03247 2973 AVPRFRVPQPAPsreapasstpplTGHSLSRVSSWASSLALHEETDPP 3020
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 97-131 7.84e-05

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 40.99  E-value: 7.84e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224451032   97 DEMDMMHaRAATLIQANWRGYWLRQKLISQMMAAK 131
Cdd:cd23767     3 EELQRMN-RAATLIQALWRGYKVRKELKKKKKKGK 36
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 1137-1158 9.71e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 37.91  E-value: 9.71e-04
                          10        20
                  ....*....|....*....|..
gi 224451032 1137 HRGAMVIQATWRGYRVRRNLAH 1158
Cdd:cd23767     9 NRAATLIQALWRGYKVRKELKK 30
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 1137-1156 3.97e-03

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 35.76  E-value: 3.97e-03
                            10        20
                    ....*....|....*....|
gi 224451032   1137 HRGAMVIQATWRGYRVRRNL 1156
Cdd:smart00015    3 TRAAIIIQAAWRGYLARKRY 22
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
 1116-1134 4.97e-03

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 459869  Cd Length: 21  Bit Score: 35.76  E-value: 4.97e-03
                           10
                   ....*....|....*....
gi 224451032  1116 AVITIQAGVRGYLARRRIR 1134
Cdd:pfam00612    3 AAIKIQAAWRGYLARKRYK 21
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 1116-1134 5.60e-03

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 35.38  E-value: 5.60e-03
                            10
                    ....*....|....*....
gi 224451032   1116 AVITIQAGVRGYLARRRIR 1134
Cdd:smart00015    5 AAIIIQAAWRGYLARKRYK 23
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 105-123 7.22e-03

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 35.38  E-value: 7.22e-03
                            10
                    ....*....|....*....
gi 224451032    105 RAATLIQANWRGYWLRQKL 123
Cdd:smart00015    4 RAAIIIQAAWRGYLARKRY 22
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1118-1195 8.08e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 40.83  E-value: 8.08e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 224451032 1118 ITIQAGVRGYLARRRIRLWHRGAMVIQATWRGYRVRRN-LAHLCRaTTTIQSAWRGYSTRRDQARHwqmlhpvTWVELG 1195
Cdd:COG5022   726 VFFKAGVLAALEDMRDAKLDNIATRIQRAIRGRYLRRRyLQALKR-IKKIQVIQHGFRLRRLVDYE-------LKWRLF 796
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 1161-1181 9.17e-03

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 35.21  E-value: 9.17e-03
                          10        20
                  ....*....|....*....|.
gi 224451032 1161 RATTTIQSAWRGYSTRRDQAR 1181
Cdd:cd23767    10 RAATLIQALWRGYKVRKELKK 30
 
Name Accession Description Interval E-value
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 276-558 6.76e-08

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 57.23  E-value: 6.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   276 GDSVKTKRVS----ARTNKARAPETPLSRRYDQAvTRPSRAQTQGPVKAETPKAPFQICPGPMITKTllqTYPVVSVTLP 351
Cdd:pfam05109  465 GPTVSTADVTsptpAGTTSGASPVTPSPSPRDNG-TESKAPDMTSPTSAVTTPTPNATSPTPAVTTP---TPNATSPTLG 540

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   352 QTYPASTMTT-TPPKTSPVPKVTiikTPAQMYPGPTVTKTAPH---TCPMPTMTKIQVHPTASRTGTPRQTCPAT----- 422
Cdd:pfam05109  541 KTSPTSAVTTpTPNATSPTPAVT---TPTPNATIPTLGKTSPTsavTTPTPNATSPTVGETSPQANTTNHTLGGTsstpv 617

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   423 ITAKNRPQVSLLASIMKSLPQVCPGpAMAKTPPQMHPVTTPAKN-------PLQTCLSATMSKTSSQRSPVGVTKPSPQT 495
Cdd:pfam05109  618 VTSPPKNATSAVTTGQHNITSSSTS-SMSLRPSSISETLSPSTSdnstshmPLLTSAHPTGGENITQVTPASTSTHHVST 696

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 224451032   496 RLPAMITKTPAQlrsvatilktlcLASPTVANVKAPP-QVAVAAGTPNTSGSIHENPPKAKATV 558
Cdd:pfam05109  697 SSPAPRPGTTSQ------------ASGPGNSSTSTKPgEVNVTKGTPPKNATSPQAPSGQKTAV 748
PHA03247 PHA03247
large tegument protein UL36; Provisional
 205-604 7.86e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 7.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  205 PQSSPLLQPPAAQGTPEPCVQGPHAARVRGLAFLPHQTVTIRFPCPVSLDAKCQPCLLTRTIRSTCLVHIEGDSVKTKR- 283
Cdd:PHA03247 2604 DRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRp 2683

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  284 --------VSARTNKARAPETPLSRRYDQAVTRPSRAQTQGPVKAETPKAPFQICPGPMITKTLLQT--------YPVVS 347
Cdd:PHA03247 2684 rrraarptVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATpggparpaRPPTT 2763

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  348 VTLPQTYPASTMTTTPPKTSPVPKVTIIKTPAQMYPGPTVTKTAPHTCPMPTMTKiqvhPTASRTGTPRQTCPATITAKN 427
Cdd:PHA03247 2764 AGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL----PPAASPAGPLPPPTSAQPTAP 2839

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  428 RPQVSLLASIMKSLPQVCPGPAMAKTPPQMHPVTTPAKNPLQTCLSATMSKTSSQRSPVGVTKPSPQtRLPAMITKTPAQ 507
Cdd:PHA03247 2840 PPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPE-RPPQPQAPPPPQ 2918

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  508 LRSVATILKTLCLASPTVANVKAPPQ-VAVAAGTPNTSGSIHENPPKAKATVNVKQAAKVVKASSPSYLAEGKIRCLAQP 586
Cdd:PHA03247 2919 PQPQPPPPPQPQPPPPPPPRPQPPLApTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTG 2998

                         410
                  ....*....|....*...
gi 224451032  587 HPGTGVPRAAAELPLEAE 604
Cdd:PHA03247 2999 HSLSRVSSWASSLALHEE 3016
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 306-557 1.19e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 49.91  E-value: 1.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   306 VTRPSRAQTQGPVKAETPKAPFQICPGPMITKTLLQTyPVVSVTLPQTYPASTMTTTPPKTSPVPKVTIIKTPAqmyPGP 385
Cdd:pfam05109  405 ITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFAA-PNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPT---PAG 480

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   386 TVTKTAPHTcPMPTmtkiqVHPTASRTGTPRQTCPATITAKNRPQVSllasimkslpqvCPGPAmaktppqmhpVTTPAK 465
Cdd:pfam05109  481 TTSGASPVT-PSPS-----PRDNGTESKAPDMTSPTSAVTTPTPNAT------------SPTPA----------VTTPTP 532

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   466 NplqtCLSATMSKTSSQRSpvgVTKPSPQTRLPAMITKTPAQLRSVATILKTlclasptvanvkaPPQVAVAAGTPN-TS 544
Cdd:pfam05109  533 N----ATSPTLGKTSPTSA---VTTPTPNATSPTPAVTTPTPNATIPTLGKT-------------SPTSAVTTPTPNaTS 592

                          250
                   ....*....|...
gi 224451032   545 GSIHENPPKAKAT 557
Cdd:pfam05109  593 PTVGETSPQANTT 605
PHA03247 PHA03247
large tegument protein UL36; Provisional
 351-862 1.20e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 1.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  351 PQTYPASTMTTTPPKTSPVPKvtiiktPAQMYPGPTVTKTA--PHTCPMPTMTKIQVHPTASRTGTPRQTCPATITAKNR 428
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSVPPPR------PAPRPSEPAVTSRArrPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  429 PQvsllASIMKSLPQVCPGPAMAKTPPQMHPVTTPAknPLQTCLSatmSKTSSQRSPVGVTKPSPQTRLPAMitktPAQL 508
Cdd:PHA03247 2626 PP----PPSPSPAANEPDPHPPPTVPPPERPRDDPA--PGRVSRP---RRARRLGRAAQASSPPQRPRRRAA----RPTV 2692

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  509 RSVATILKtlclaSPTVANVKAPPQVAVAAGTPNTSGsihenPPKAKATVNVKQAAKVVKASSPSYLAEGKIRCLAQPHP 588
Cdd:PHA03247 2693 GSLTSLAD-----PPPPPPTPEPAPHALVSATPLPPG-----PAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT 2762

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  589 GTGVPRAAAElpleaekiktgtqkqaktdmAFKTSVAVEMAGAPSWTKVAEEGDKPPHVYVPVDMAVTLPRGQLAAPLTN 668
Cdd:PHA03247 2763 TAGPPAPAPP--------------------AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAA 2822

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  669 ASSQRHPPCLSQRPLAAPLTKASSQGHLPTELTKTPS--LAHLDTCLSKMHSQTHLATGAVKVQSQAPLAtclTKTQSRG 746
Cdd:PHA03247 2823 SPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGgdVRRRPPSRSPAAKPAAPARPPVRRLARPAVS---RSTESFA 2899

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032  747 QPITDITTCLIPAHQAADLSSNTHSQvlltgsKVSNHACQRLGGLSAPPWAKPEDRQTQPQPHGHVPGKTTqGGPCPAAC 826
Cdd:PHA03247 2900 LPPDQPERPPQPQAPPPPQPQPQPPP------PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWL-GALVPGRV 2972

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 224451032  827 EVQGMLVPPMAP------------TGHSTCNVESWGDNGATRAQPSMP 862
Cdd:PHA03247 2973 AVPRFRVPQPAPsreapasstpplTGHSLSRVSSWASSLALHEETDPP 3020
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 97-131 7.84e-05

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 40.99  E-value: 7.84e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224451032   97 DEMDMMHaRAATLIQANWRGYWLRQKLISQMMAAK 131
Cdd:cd23767     3 EELQRMN-RAATLIQALWRGYKVRKELKKKKKKGK 36
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 340-759 2.54e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 45.34  E-value: 2.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   340 LQTYPVVSVTLPQTYPASTMTTTPPKTSPVPKVTIIKTPAQMY-PGPTVTKTAPHTcpmptmtkiqvhPTASRTGTPRQT 418
Cdd:pfam17823   62 AATAAPAPVTLTKGTSAAHLNSTEVTAEHTPHGTDLSEPATREgAADGAASRALAA------------AASSSPSSAAQS 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   419 CPATITAKNRPQVSLLASIMKSLPQVCpGPAMAKTPPQMHPVTTPAKNPLQTCLSATMSKTSSQRSPVGVTKPSPQTRLP 498
Cdd:pfam17823  130 LPAAIAALPSEAFSAPRAAACRANASA-APRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTP 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   499 AMITKTPAqLRSVATILKTLCLASPTVANVKAPPQVAVAAGTPNTSGSIhenppkAKATVNVKQAAKVVKASSPSYlaeg 578
Cdd:pfam17823  209 ARGISTAA-TATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATL------AAAAGTVASAAGTINMGDPHA---- 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   579 kirclAQPHPGTGVPR-AAAELPLEAEKIKT-GTQKQAKTDMAFKTSVAvemAGAPSWTKVAEEGDKPPHVYVPVDMAVT 656
Cdd:pfam17823  278 -----RRLSPAKHMPSdTMARNPAAPMGAQAqGPIIQVSTDQPVHNTAG---EPTPSPSNTTLEPNTPKSVASTNLAVVT 349

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   657 LPRGQL----AAPLTNASSQRHPPCLSQRPLAAPLTKASSQGHL-PTELTKTPSLAHLDTCLSKMHSQTHLATGAVKVQS 731
Cdd:pfam17823  350 TTKAQAkepsASPVPVLHTSMIPEVEATSPTTQPSPLLPTQGAAgPGILLAPEQVATEATAGTASAGPTPRSSGDPKTLA 429

                          410       420
                   ....*....|....*....|....*...
gi 224451032   732 qapLATCLTKTQsrGQPITDITTCLIPA 759
Cdd:pfam17823  430 ---MASCQLSTQ--GQYLVVTTDPLTPA 452
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 1137-1158 9.71e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 37.91  E-value: 9.71e-04
                          10        20
                  ....*....|....*....|..
gi 224451032 1137 HRGAMVIQATWRGYRVRRNLAH 1158
Cdd:cd23767     9 NRAATLIQALWRGYKVRKELKK 30
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 313-554 3.37e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 3.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   313 QTQGPVKAETPKAPFQICPGPMITKTLLQTYPVVSVTL--PQTYPASTMTTTPPKTSPVPKVTIIKTPA---QMYPGP-T 386
Cdd:pfam03154  168 QTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSvpPQGSPATSQPPNQTQSTAAPHTLIQQTPTlhpQRLPSPhP 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   387 VTKTAPHTCPmPTMTKIQVHPTASRTGT------PRQTCPATITAKNRPQVSLLASIMkSLPQVCPGPA-MAKTPPQMHP 459
Cdd:pfam03154  248 PLQPMTQPPP-PSQVSPQPLPQPSLHGQmppmphSLQTGPSHMQHPVPPQPFPLTPQS-SQSQVPPGPSpAAPGQSQQRI 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   460 VTTPAKNPLQTCLSATMSKTSSQRSPVGVTKPSPQTRLPAMIT----KTPAQLRSvatilktlclASPTVANVKAPPQVA 535
Cdd:pfam03154  326 HTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNpqshKHPPHLSG----------PSPFQMNSNLPPPPA 395

                          250
                   ....*....|....*....
gi 224451032   536 VaagTPNTSGSIHeNPPKA 554
Cdd:pfam03154  396 L---KPLSSLSTH-HPPSA 410
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 377-704 3.67e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 3.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   377 TPAQMYPGPTVTKTAPHTCPMPTMTKIQVHPTASRTGTPRQTCPATI-------TAKNRPQ-VSLLASIMKSLPQVCP-- 446
Cdd:pfam03154  180 AASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAphtliqqTPTLHPQrLPSPHPPLQPMTQPPPps 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   447 -GPAMAKTPPQMHPVTTPAKNPLQTCLSATMSKTSSQRSPV------GVTKPSPQTRLPAMITKTPAQLRSVATIL---- 515
Cdd:pfam03154  260 qVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLtpqssqSQVPPGPSPAAPGQSQQRIHTPPSQSQLQsqqp 339

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   516 ---KTLCLASPTVANVKAPPQVAVAagtPNTSGSIHENPPKAKATVNVKQAAKVvkassPSYLAEGKIRCLAQPHPGTGV 592
Cdd:pfam03154  340 preQPLPPAPLSMPHIKPPPTTPIP---QLPNPQSHKHPPHLSGPSPFQMNSNL-----PPPPALKPLSSLSTHHPPSAH 411

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451032   593 PRAAAELPLEAEKIKTGTQKQAKTDMAFKTSVAVEMAGAPSWTKVAEEGDKPPHVYVPVDMAVTLPRGQLAAPLTNASSQ 672
Cdd:pfam03154  412 PPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPG 491

                          330       340       350
                   ....*....|....*....|....*....|..
gi 224451032   673 RHPPCLSQRPLAAPLTKASSQGHLPTELTKTP 704
Cdd:pfam03154  492 IQPPSSASVSSSGPVPAAVSCPLPPVQIKEEA 523
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 1137-1156 3.97e-03

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 35.76  E-value: 3.97e-03
                            10        20
                    ....*....|....*....|
gi 224451032   1137 HRGAMVIQATWRGYRVRRNL 1156
Cdd:smart00015    3 TRAAIIIQAAWRGYLARKRY 22
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
 1116-1134 4.97e-03

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 459869  Cd Length: 21  Bit Score: 35.76  E-value: 4.97e-03
                           10
                   ....*....|....*....
gi 224451032  1116 AVITIQAGVRGYLARRRIR 1134
Cdd:pfam00612    3 AAIKIQAAWRGYLARKRYK 21
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 1116-1134 5.60e-03

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 35.38  E-value: 5.60e-03
                            10
                    ....*....|....*....
gi 224451032   1116 AVITIQAGVRGYLARRRIR 1134
Cdd:smart00015    5 AAIIIQAAWRGYLARKRYK 23
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 105-123 7.22e-03

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 35.38  E-value: 7.22e-03
                            10
                    ....*....|....*....
gi 224451032    105 RAATLIQANWRGYWLRQKL 123
Cdd:smart00015    4 RAAIIIQAAWRGYLARKRY 22
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1118-1195 8.08e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 40.83  E-value: 8.08e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 224451032 1118 ITIQAGVRGYLARRRIRLWHRGAMVIQATWRGYRVRRN-LAHLCRaTTTIQSAWRGYSTRRDQARHwqmlhpvTWVELG 1195
Cdd:COG5022   726 VFFKAGVLAALEDMRDAKLDNIATRIQRAIRGRYLRRRyLQALKR-IKKIQVIQHGFRLRRLVDYE-------LKWRLF 796
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 1161-1181 9.17e-03

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 35.21  E-value: 9.17e-03
                          10        20
                  ....*....|....*....|.
gi 224451032 1161 RATTTIQSAWRGYSTRRDQAR 1181
Cdd:cd23767    10 RAATLIQALWRGYKVRKELKK 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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