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Conserved domains on  [gi|1890343393|ref|NP_001138471|]
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integrin alpha-V isoform 2 precursor [Homo sapiens]

Protein Classification

integrin alpha( domain architecture ID 12146455)

integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions; integrin alpha is a transmembrane receptor that facilitates cell-extracellular matrix (ECM) adhesion; integrin alpha is a transmembrane receptor that facilitates cell-extracellular matrix (ECM) adhesion

Gene Ontology:  GO:0007155|GO:0008305|GO:0005178|GO:0046872
PubMed:  3028640|2199285|12297042|12826403|14689578|12361595|12234368

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 422-868 5.15e-163

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 486.44  E-value: 5.15e-163
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890343393  422 RPVITVNAGLEVYPSILNQDNKTCSLPGTalKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSR 501
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTGT--PVSCFTVRACFSYTGKPIPNPSLVLNYELELDRQKKKGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890343393  502 SPSHSKNMTISRGGLMQCEELIAYLRDEseFRDKLTPITIFMEYRL--DYRTAADTTGLQPILNQFTPANISRQAHILLD 579
Cdd:pfam08441   79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890343393  580 CGEDNVCKPKLEVSV----DSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVvRNNEALARLSCAFK 655
Cdd:pfam08441  157 CGEDNVCVPDLQLSAkfdsRESDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGV-RREGSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890343393  656 TENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPD 735
Cdd:pfam08441  236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPD 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890343393  736 HVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNT-LLYILHYDIDGPMNCTSDMEINP 814
Cdd:pfam08441  316 QVVGGSVKGESAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKwLLYLLDVQGQGKGECSPQNEINP 395

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1890343393  815 LRIKISSLQTTEkndtvAGQGERDHLITKRDLALSEG----DIHTLGCG-VAQCLKIVC 868
Cdd:pfam08441  396 LNLTQSLESSKP-----LRTSRVHHVVKRRDVLKSEKatqtASVLLSCDsGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 321-375 5.62e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 64.32  E-value: 5.62e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1890343393   321 FARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKK-GIVYIFNGRSTGLNAVPSQIL 375
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 202-242 5.31e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 5.31e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1890343393   202 DDSYLGYSVA-VGDFNGDGIDDFVSGVPRA--ARTLGMVYIYDG 242
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRAndAGETGAVYVYFG 44
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 256-309 2.28e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.53  E-value: 2.28e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1890343393   256 MAAYFGFSVA-ATDINGDDYADVFIGAPLFMDRgsdgklQEVGQVSVSLQRASGD 309
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDA------GETGAVYVYFGSSGGG 49
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 388-430 1.15e-06

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 46.60  E-value: 1.15e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1890343393   388 FGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAG 430
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 175-225 1.32e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


:

Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 37.98  E-value: 1.32e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1890343393  175 IVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVS 225
Cdd:pfam13517   11 VVANDGGLRLYLNNGDGTFTFITSVSLGGGGGGLSVAVGDLDGDGRLDLLV 61
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 422-868 5.15e-163

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 486.44  E-value: 5.15e-163
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890343393  422 RPVITVNAGLEVYPSILNQDNKTCSLPGTalKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSR 501
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTGT--PVSCFTVRACFSYTGKPIPNPSLVLNYELELDRQKKKGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890343393  502 SPSHSKNMTISRGGLMQCEELIAYLRDEseFRDKLTPITIFMEYRL--DYRTAADTTGLQPILNQFTPANISRQAHILLD 579
Cdd:pfam08441   79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890343393  580 CGEDNVCKPKLEVSV----DSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVvRNNEALARLSCAFK 655
Cdd:pfam08441  157 CGEDNVCVPDLQLSAkfdsRESDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGV-RREGSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890343393  656 TENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPD 735
Cdd:pfam08441  236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPD 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890343393  736 HVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNT-LLYILHYDIDGPMNCTSDMEINP 814
Cdd:pfam08441  316 QVVGGSVKGESAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKwLLYLLDVQGQGKGECSPQNEINP 395

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1890343393  815 LRIKISSLQTTEkndtvAGQGERDHLITKRDLALSEG----DIHTLGCG-VAQCLKIVC 868
Cdd:pfam08441  396 LNLTQSLESSKP-----LRTSRVHHVVKRRDVLKSEKatqtASVLLSCDsGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 321-375 5.62e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 64.32  E-value: 5.62e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1890343393   321 FARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKK-GIVYIFNGRSTGLNAVPSQIL 375
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 202-242 5.31e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 5.31e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1890343393   202 DDSYLGYSVA-VGDFNGDGIDDFVSGVPRA--ARTLGMVYIYDG 242
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRAndAGETGAVYVYFG 44
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 324-360 1.28e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.36  E-value: 1.28e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1890343393  324 FGSAIApLGDLDQDGFNDIAIAAPYGGEDKKGIVYIF 360
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 256-309 2.28e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.53  E-value: 2.28e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1890343393   256 MAAYFGFSVA-ATDINGDDYADVFIGAPLFMDRgsdgklQEVGQVSVSLQRASGD 309
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDA------GETGAVYVYFGSSGGG 49
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 207-240 4.03e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 47.12  E-value: 4.03e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1890343393  207 GYSVAVGDFNGDGIDDFVSGVPRAART-LGMVYIY 240
Cdd:pfam01839    2 GYSVAVGDLNGDGYADLAVGAPGEGGAgAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 388-430 1.15e-06

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 46.60  E-value: 1.15e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1890343393   388 FGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAG 430
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 260-301 1.17e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 45.96  E-value: 1.17e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1890343393  260 FGFSVAATDINGDDYADVFIGAPLFMDRGSdgklqevGQVSV 301
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAGA-------GAVYV 35
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 175-225 1.32e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 37.98  E-value: 1.32e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1890343393  175 IVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVS 225
Cdd:pfam13517   11 VVANDGGLRLYLNNGDGTFTFITSVSLGGGGGGLSVAVGDLDGDGRLDLLV 61
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 422-868 5.15e-163

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 486.44  E-value: 5.15e-163
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890343393  422 RPVITVNAGLEVYPSILNQDNKTCSLPGTalKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSR 501
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTGT--PVSCFTVRACFSYTGKPIPNPSLVLNYELELDRQKKKGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890343393  502 SPSHSKNMTISRGGLMQCEELIAYLRDEseFRDKLTPITIFMEYRL--DYRTAADTTGLQPILNQFTPANISRQAHILLD 579
Cdd:pfam08441   79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890343393  580 CGEDNVCKPKLEVSV----DSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVvRNNEALARLSCAFK 655
Cdd:pfam08441  157 CGEDNVCVPDLQLSAkfdsRESDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGV-RREGSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890343393  656 TENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPD 735
Cdd:pfam08441  236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPD 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890343393  736 HVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNT-LLYILHYDIDGPMNCTSDMEINP 814
Cdd:pfam08441  316 QVVGGSVKGESAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKwLLYLLDVQGQGKGECSPQNEINP 395

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1890343393  815 LRIKISSLQTTEkndtvAGQGERDHLITKRDLALSEG----DIHTLGCG-VAQCLKIVC 868
Cdd:pfam08441  396 LNLTQSLESSKP-----LRTSRVHHVVKRRDVLKSEKatqtASVLLSCDsGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 321-375 5.62e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 64.32  E-value: 5.62e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1890343393   321 FARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKK-GIVYIFNGRSTGLNAVPSQIL 375
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 202-242 5.31e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 5.31e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1890343393   202 DDSYLGYSVA-VGDFNGDGIDDFVSGVPRA--ARTLGMVYIYDG 242
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRAndAGETGAVYVYFG 44
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 324-360 1.28e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.36  E-value: 1.28e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1890343393  324 FGSAIApLGDLDQDGFNDIAIAAPYGGEDKKGIVYIF 360
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 256-309 2.28e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.53  E-value: 2.28e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1890343393   256 MAAYFGFSVA-ATDINGDDYADVFIGAPLFMDRgsdgklQEVGQVSVSLQRASGD 309
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDA------GETGAVYVYFGSSGGG 49
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 207-240 4.03e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 47.12  E-value: 4.03e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1890343393  207 GYSVAVGDFNGDGIDDFVSGVPRAART-LGMVYIY 240
Cdd:pfam01839    2 GYSVAVGDLNGDGYADLAVGAPGEGGAgAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 388-430 1.15e-06

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 46.60  E-value: 1.15e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1890343393   388 FGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAG 430
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 260-301 1.17e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 45.96  E-value: 1.17e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1890343393  260 FGFSVAATDINGDDYADVFIGAPLFMDRGSdgklqevGQVSV 301
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAGA-------GAVYV 35
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 214-279 3.70e-06

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 45.29  E-value: 3.70e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1890343393  214 DFNGDGIDDFVSGVPRAARtlgmVYIYDGKNM---SSLYNFTGeqmaAYFGFSVAATDINGDDYADVFI 279
Cdd:pfam13517    1 DLDGDGKLDLVVANDGGLR----LYLNNGDGTftfITSVSLGG----GGGGLSVAVGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 175-225 1.32e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 37.98  E-value: 1.32e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1890343393  175 IVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVS 225
Cdd:pfam13517   11 VVANDGGLRLYLNNGDGTFTFITSVSLGGGGGGLSVAVGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 333-408 1.51e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 37.59  E-value: 1.51e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1890343393  333 DLDQDGFNDIAIAapyggEDKKGIVYIFNGRSTGLNAVPSQILEGQWAarsMPPSFGysmkgatDIDKNGYPDLIV 408
Cdd:pfam13517    1 DLDGDGKLDLVVA-----NDGGLRLYLNNGDGTFTFITSVSLGGGGGG---LSVAVG-------DLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 268-344 1.62e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 37.59  E-value: 1.62e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1890343393  268 DINGDDYADVFIGAPlfmdrgsdgklqevGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAplGDLDQDGFNDIAI 344
Cdd:pfam13517    1 DLDGDGKLDLVVAND--------------GGLRLYLNNGDGTFTFITSVSLGGGGGGLSVAV--GDLDGDGRLDLLV 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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