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Conserved domains on  [gi|222136607|ref|NP_001138395|]
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intraflagellar transport protein 56 isoform 3 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 31-193 1.55e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 1.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607  31 EELLSKRDFTGAITLleeYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQN-RLLFHLAHKFNDEKKL 109
Cdd:COG2956   84 QDYLKAGLLDRAEEL---LEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENaHAYCELAELYLEQGDY 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607 110 MSFHQNLQDVTED-------QLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQ 182
Cdd:COG2956  161 DEAIEALEKALKLdpdcaraLLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALE 240

                        170
                 ....*....|.
gi 222136607 183 QIPDSTIALNL 193
Cdd:COG2956  241 LDPSDDLLLAL 251
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 123-286 2.86e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.79  E-value: 2.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607 123 QLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLY 202
Cdd:COG2956   45 HLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEG 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607 203 NGRAAEAELKSLM----DNASSSFEFAKELIRHNLVvfrggEGALQVLPPLVDVIP---EARLNLVIYYLRQDDVQEAYN 275
Cdd:COG2956  125 DWEKAIEVLERLLklgpENAHAYCELAELYLEQGDY-----DEAIEALEKALKLDPdcaRALLLLAELYLEQGDYEEAIA 199

                        170
                 ....*....|.
gi 222136607 276 LIKDLEPTTPQ 286
Cdd:COG2956  200 ALERALEQDPD 210
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 31-193 1.55e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 1.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607  31 EELLSKRDFTGAITLleeYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQN-RLLFHLAHKFNDEKKL 109
Cdd:COG2956   84 QDYLKAGLLDRAEEL---LEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENaHAYCELAELYLEQGDY 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607 110 MSFHQNLQDVTED-------QLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQ 182
Cdd:COG2956  161 DEAIEALEKALKLdpdcaraLLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALE 240

                        170
                 ....*....|.
gi 222136607 183 QIPDSTIALNL 193
Cdd:COG2956  241 LDPSDDLLLAL 251
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 33-286 3.61e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.62  E-value: 3.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607   33 LLSKRDFTGAITLLEEYENATKEENcnSEVWVNLACTYFFLGMYKQAE---AAGFKASKSRLQNRL-LFHLAHKFNDEKK 108
Cdd:TIGR02917 100 YLLQGKFQQVLDELPGKTLLDDEGA--AELLALRGLAYLGLGQLELAQksyEQALAIDPRSLYAKLgLAQLALAENRFDE 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607  109 LMSF-HQNLQ---DVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQI 184
Cdd:TIGR02917 178 ARALiDEVLTadpGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKA 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607  185 PDSTIALNLKACNHFRlyNGRAAEAeLKSLMDNASSSFEFAKELIRHNLVVFRGG--EGALQVLPPLVDVIPE---ARLN 259
Cdd:TIGR02917 258 PNSPLAHYLKALVDFQ--KKNYEDA-RETLQDALKSAPEYLPALLLAGASEYQLGnlEQAYQYLNQILKYAPNshqARRL 334

                         250       260
                  ....*....|....*....|....*..
gi 222136607  260 LVIYYLRQDDVQEAYNLIKDLEPTTPQ 286
Cdd:TIGR02917 335 LASIQLRLGRVDEAIATLSPALGLDPD 361
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 123-286 2.86e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.79  E-value: 2.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607 123 QLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLY 202
Cdd:COG2956   45 HLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEG 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607 203 NGRAAEAELKSLM----DNASSSFEFAKELIRHNLVvfrggEGALQVLPPLVDVIP---EARLNLVIYYLRQDDVQEAYN 275
Cdd:COG2956  125 DWEKAIEVLERLLklgpENAHAYCELAELYLEQGDY-----DEAIEALEKALKLDPdcaRALLLLAELYLEQGDYEEAIA 199

                        170
                 ....*....|.
gi 222136607 276 LIKDLEPTTPQ 286
Cdd:COG2956  200 ALERALEQDPD 210
TPR_19 pfam14559
Tetratricopeptide repeat;
136-195 3.98e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 36.02  E-value: 3.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607  136 YQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKA 195
Cdd:pfam14559   4 YAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALLA 63
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 31-193 1.55e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 1.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607  31 EELLSKRDFTGAITLleeYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQN-RLLFHLAHKFNDEKKL 109
Cdd:COG2956   84 QDYLKAGLLDRAEEL---LEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENaHAYCELAELYLEQGDY 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607 110 MSFHQNLQDVTED-------QLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQ 182
Cdd:COG2956  161 DEAIEALEKALKLdpdcaraLLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALE 240

                        170
                 ....*....|.
gi 222136607 183 QIPDSTIALNL 193
Cdd:COG2956  241 LDPSDDLLLAL 251
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 46-280 3.28e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.04  E-value: 3.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607  46 LEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQN-RLLFHLAHKFNDEKKL---MSFHQNLQDVTE 121
Cdd:COG2956   28 IDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRaEALLELAQDYLKAGLLdraEELLEKLLELDP 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607 122 D----QLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACN 197
Cdd:COG2956  108 DdaeaLRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAEL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607 198 HFRLYNGRAAEAELKSLMDNASSSFEFAKELIRhnLVVFRG-GEGALQVLPPLVDVIPE--ARLNLVIYYLRQDDVQEAY 274
Cdd:COG2956  188 YLEQGDYEEAIAALERALEQDPDYLPALPRLAE--LYEKLGdPEEALELLRKALELDPSddLLLALADLLERKEGLEAAL 265


                 ....*.
gi 222136607 275 NLIKDL 280
Cdd:COG2956  266 ALLERQ 271
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
33-230 2.44e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.77  E-value: 2.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607  33 LLSKRDFTGAITLleeYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQN-RLLFHLA----HKFNDEK 107
Cdd:COG0457   18 YRRLGRYEEAIED---YEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDaEALNNLGlalqALGRYEE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607 108 KLMSFHQNLQ---DVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQI 184
Cdd:COG0457   95 ALEDYDKALEldpDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAA 174

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 222136607 185 PDSTIALNLKACNHFRLYNGRAAEAELKSLMDNASSSFEFAKELIR 230
Cdd:COG0457  175 LAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALA 220
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 33-286 3.61e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.62  E-value: 3.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607   33 LLSKRDFTGAITLLEEYENATKEENcnSEVWVNLACTYFFLGMYKQAE---AAGFKASKSRLQNRL-LFHLAHKFNDEKK 108
Cdd:TIGR02917 100 YLLQGKFQQVLDELPGKTLLDDEGA--AELLALRGLAYLGLGQLELAQksyEQALAIDPRSLYAKLgLAQLALAENRFDE 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607  109 LMSF-HQNLQ---DVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQI 184
Cdd:TIGR02917 178 ARALiDEVLTadpGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKA 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607  185 PDSTIALNLKACNHFRlyNGRAAEAeLKSLMDNASSSFEFAKELIRHNLVVFRGG--EGALQVLPPLVDVIPE---ARLN 259
Cdd:TIGR02917 258 PNSPLAHYLKALVDFQ--KKNYEDA-RETLQDALKSAPEYLPALLLAGASEYQLGnlEQAYQYLNQILKYAPNshqARRL 334

                         250       260
                  ....*....|....*....|....*..
gi 222136607  260 LVIYYLRQDDVQEAYNLIKDLEPTTPQ 286
Cdd:TIGR02917 335 LASIQLRLGRVDEAIATLSPALGLDPD 361
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 30-193 1.01e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.98  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607  30 LEELLSKRDFTGAITLleeYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAgfkasksrlqnrllFHLAHKFNDekkl 109
Cdd:COG3914   85 ALLLQALGRYEEALAL---YRRALALNPDNAEALFNLGNLLLALGRLEEALAA--------------LRRALALNP---- 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607 110 msfhqnlqDVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTI 189
Cdd:COG3914  144 --------DFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNAD 215


                 ....
gi 222136607 190 ALNL 193
Cdd:COG3914  216 AHSN 219
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 76-286 2.42e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.83  E-value: 2.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607  76 YKQAEAAGFKASKSRLQNRLLFHLAHKFNDEKKLMSFHQNLQDVTEDQL----------SLASIHYMRSHYQEAIDIYKR 145
Cdd:COG3914   24 AELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAallllaalleLAALLLQALGRYEEALALYRR 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607 146 ILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLynGRAAEAElkslmdnasssfefa 225
Cdd:COG3914  104 ALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRL--GRLEEAI--------------- 166

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 222136607 226 kELIRHnlvvfrggegALQVLPPLvdviPEARLNLVIYYLRQDDVQEA---YNLIKDLEPTTPQ 286
Cdd:COG3914  167 -AALRR----------ALELDPDN----AEALNNLGNALQDLGRLEEAiaaYRRALELDPDNAD 215
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 123-286 2.86e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.79  E-value: 2.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607 123 QLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLY 202
Cdd:COG2956   45 HLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEG 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607 203 NGRAAEAELKSLM----DNASSSFEFAKELIRHNLVvfrggEGALQVLPPLVDVIP---EARLNLVIYYLRQDDVQEAYN 275
Cdd:COG2956  125 DWEKAIEVLERLLklgpENAHAYCELAELYLEQGDY-----DEAIEALEKALKLDPdcaRALLLLAELYLEQGDYEEAIA 199

                        170
                 ....*....|.
gi 222136607 276 LIKDLEPTTPQ 286
Cdd:COG2956  200 ALERALEQDPD 210
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 31-187 3.91e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.56  E-value: 3.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607  31 EELLSKRDFTGAITLLEEyenATKEENCNSEVWVNLACTYFFLGMYKQAEAagfkasksrlqnrlLFHLAHKFNdekklm 110
Cdd:COG4783   12 QALLLAGDYDEAEALLEK---ALELDPDNPEAFALLGEILLQLGDLDEAIV--------------LLHEALELD------ 68

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 222136607 111 sfhqnlQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDS 187
Cdd:COG4783   69 ------PDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 33-315 4.03e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 4.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607   33 LLSKRDFTGAITLLEEyenATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKAsksrlqnrllfhLAHKFNDEKKL--- 109
Cdd:TIGR02917 169 ALAENRFDEARALIDE---VLTADPGNVDALLLKGDLLLSLGNIELALAAYRKA------------IALRPNNIAVLlal 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607  110 --MSFHQNLQDVTEDQLSL---------------ASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDV 172
Cdd:TIGR02917 234 atILIEAGEFEEAEKHADAllkkapnsplahylkALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQ 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607  173 SQEVLAVYLQQIPDSTIALNLKACnhFRLYNGRAAEA--ELKSLMDNASSS-----------------------FEFAKE 227
Cdd:TIGR02917 314 AYQYLNQILKYAPNSHQARRLLAS--IQLRLGRVDEAiaTLSPALGLDPDDpaalsllgeaylalgdfekaaeyLAKATE 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607  228 L------IRHNLVVF-------RGGEGALQVLPPLVDVIPEARLNLVIYYLRQDDVQEAYNLIKDLE---PTTPQEYILK 291
Cdd:TIGR02917 392 LdpenaaARTQLGISklsqgdpSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEkkqPDNASLHNLL 471

                         330       340
                  ....*....|....*....|....*...
gi 222136607  292 GVVNAALGQEMGSRDH----MKIAQQFF 315
Cdd:TIGR02917 472 GAIYLGKGDLAKAREAfekaLSIEPDFF 499
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 126-300 2.15e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.10  E-value: 2.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607 126 LASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGR 205
Cdd:COG2956   14 KGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607 206 AAEAELKSLMDNASSSFEFAKELIRhnLVVFRG-GEGALQVLPPLVDVIPE---ARLNLVIYYLRQDDVQEAYNLIK--- 278
Cdd:COG2956   94 RAEELLEKLLELDPDDAEALRLLAE--IYEQEGdWEKAIEVLERLLKLGPEnahAYCELAELYLEQGDYDEAIEALEkal 171

                        170       180
                 ....*....|....*....|..
gi 222136607 279 DLEPTTPQEYILKGVVNAALGQ 300
Cdd:COG2956  172 KLDPDCARALLLLAELYLEQGD 193
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 123-215 2.59e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.25  E-value: 2.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607 123 QLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLY 202
Cdd:COG4783   41 FALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALG 120

                         90
                 ....*....|...
gi 222136607 203 NGRAAEAELKSLM 215
Cdd:COG4783  121 RPDEAIAALEKAL 133
TPR_19 pfam14559
Tetratricopeptide repeat;
136-195 3.98e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 36.02  E-value: 3.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136607  136 YQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKA 195
Cdd:pfam14559   4 YAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALLA 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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