sodium channel protein subunit alpha is the ion conducting pore forming subunit of the channel that mediates the voltage-dependent sodium ion permeability of excitable membranes
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1283-1554
2.32e-67
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 227.92 E-value: 2.32e-67
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1604-1854
2.80e-55
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 192.87 E-value: 2.80e-55
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
798-1009
1.08e-47
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 171.30 E-value: 1.08e-47
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
141-425
5.61e-47
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 169.37 E-value: 5.61e-47
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1544-1596
8.62e-29
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.
:
Pssm-ID: 240441 Cd Length: 54 Bit Score: 109.96 E-value: 8.62e-29
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1035-1279
7.23e-27
Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.
:
Pssm-ID: 461936 Cd Length: 195 Bit Score: 109.73 E-value: 7.23e-27
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
544-729
3.72e-25
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.
:
Pssm-ID: 463401 Cd Length: 163 Bit Score: 103.66 E-value: 3.72e-25
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1865-1912
4.36e-05
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
The actual alignment was detected with superfamily member pfam16905:
Pssm-ID: 465306 Cd Length: 54 Bit Score: 42.64 E-value: 4.36e-05
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1283-1554
2.32e-67
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 227.92 E-value: 2.32e-67
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1604-1854
2.80e-55
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 192.87 E-value: 2.80e-55
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
798-1009
1.08e-47
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 171.30 E-value: 1.08e-47
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
141-425
5.61e-47
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 169.37 E-value: 5.61e-47
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1544-1596
8.62e-29
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.
Pssm-ID: 240441 Cd Length: 54 Bit Score: 109.96 E-value: 8.62e-29
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1035-1279
7.23e-27
Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.
Pssm-ID: 461936 Cd Length: 195 Bit Score: 109.73 E-value: 7.23e-27
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
544-729
3.72e-25
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.
Pssm-ID: 463401 Cd Length: 163 Bit Score: 103.66 E-value: 3.72e-25
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1865-1912
4.36e-05
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
Pssm-ID: 465306 Cd Length: 54 Bit Score: 42.64 E-value: 4.36e-05
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1283-1554
2.32e-67
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 227.92 E-value: 2.32e-67
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1604-1854
2.80e-55
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 192.87 E-value: 2.80e-55
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
798-1009
1.08e-47
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 171.30 E-value: 1.08e-47
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
141-425
5.61e-47
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 169.37 E-value: 5.61e-47
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1544-1596
8.62e-29
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.
Pssm-ID: 240441 Cd Length: 54 Bit Score: 109.96 E-value: 8.62e-29
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1035-1279
7.23e-27
Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.
Pssm-ID: 461936 Cd Length: 195 Bit Score: 109.73 E-value: 7.23e-27
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
544-729
3.72e-25
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.
Pssm-ID: 463401 Cd Length: 163 Bit Score: 103.66 E-value: 3.72e-25
Polycystin cation channel; This family contains the cation channel region from group II of ...
1640-1847
4.49e-08
Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.
Pssm-ID: 462341 [Multi-domain] Cd Length: 225 Bit Score: 56.13 E-value: 4.49e-08
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1865-1912
4.36e-05
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
Pssm-ID: 465306 Cd Length: 54 Bit Score: 42.64 E-value: 4.36e-05
Polycystin cation channel; This family contains the cation channel region from group II of ...
886-980
1.84e-03
Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.
Pssm-ID: 462341 [Multi-domain] Cd Length: 225 Bit Score: 41.88 E-value: 1.84e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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