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Conserved domains on  [gi|221378595|ref|NP_001138030|]
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glucose transporter 4 enhancer factor, isoform D [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4772 super family cl24535
Domain of unknown function (DUF4772); This presumed domain is functionally uncharacterized. ...
 5-177 2.11e-28

Domain of unknown function (DUF4772); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 107 and 124 amino acids in length. There is a single completely conserved residue V that may be functionally important.


The actual alignment was detected with superfamily member pfam15997:

Pssm-ID: 464964  Cd Length: 112  Bit Score: 106.71  E-value: 2.11e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221378595    5 RRLAKRSIIGTKVCAKGPDGLWYSG--TISDVKTPPSYSGPlsppppptfvvpGEAPinadTRYLVRFDfktavesptat 82
Cdd:pfam15997   1 RRLGKRSLLGTRVLAPGADGDGYPGvgVPSDPQQELLDASE------------GLAP----QPYTVLFD----------- 53

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221378595   83 tssaastsstsstdpsvivetrraanvhispaqalrrSAMIKEFRESDLIGPGFRSIMDTELQPGQRVYFTYNGREQSGD 162
Cdd:pfam15997  54 -------------------------------------GGQCREYSEEELIGPGFQGLQQVPLQPGQKVYVTYNGREVAGL 96

                         170
                  ....*....|....*
gi 221378595  163 VVKHDATKDEVIVKI 177
Cdd:pfam15997  97 VEQHSWAEDEVTVQL 111
 
Name Accession Description Interval E-value
DUF4772 pfam15997
Domain of unknown function (DUF4772); This presumed domain is functionally uncharacterized. ...
 5-177 2.11e-28

Domain of unknown function (DUF4772); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 107 and 124 amino acids in length. There is a single completely conserved residue V that may be functionally important.


Pssm-ID: 464964  Cd Length: 112  Bit Score: 106.71  E-value: 2.11e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221378595    5 RRLAKRSIIGTKVCAKGPDGLWYSG--TISDVKTPPSYSGPlsppppptfvvpGEAPinadTRYLVRFDfktavesptat 82
Cdd:pfam15997   1 RRLGKRSLLGTRVLAPGADGDGYPGvgVPSDPQQELLDASE------------GLAP----QPYTVLFD----------- 53

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221378595   83 tssaastsstsstdpsvivetrraanvhispaqalrrSAMIKEFRESDLIGPGFRSIMDTELQPGQRVYFTYNGREQSGD 162
Cdd:pfam15997  54 -------------------------------------GGQCREYSEEELIGPGFQGLQQVPLQPGQKVYVTYNGREVAGL 96

                         170
                  ....*....|....*
gi 221378595  163 VVKHDATKDEVIVKI 177
Cdd:pfam15997  97 VEQHSWAEDEVTVQL 111
Tudor_ZGPAT cd20384
Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and ...
 13-36 7.75e-03

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410455  Cd Length: 55  Bit Score: 34.51  E-value: 7.75e-03
                         10        20
                 ....*....|....*....|....
gi 221378595  13 IGTKVCAKGPDGLWYSGTISDVKT 36
Cdd:cd20384    7 EGSRCLAKYDDGLWYPATVTDIDE 30
 
Name Accession Description Interval E-value
DUF4772 pfam15997
Domain of unknown function (DUF4772); This presumed domain is functionally uncharacterized. ...
 5-177 2.11e-28

Domain of unknown function (DUF4772); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 107 and 124 amino acids in length. There is a single completely conserved residue V that may be functionally important.


Pssm-ID: 464964  Cd Length: 112  Bit Score: 106.71  E-value: 2.11e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221378595    5 RRLAKRSIIGTKVCAKGPDGLWYSG--TISDVKTPPSYSGPlsppppptfvvpGEAPinadTRYLVRFDfktavesptat 82
Cdd:pfam15997   1 RRLGKRSLLGTRVLAPGADGDGYPGvgVPSDPQQELLDASE------------GLAP----QPYTVLFD----------- 53

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221378595   83 tssaastsstsstdpsvivetrraanvhispaqalrrSAMIKEFRESDLIGPGFRSIMDTELQPGQRVYFTYNGREQSGD 162
Cdd:pfam15997  54 -------------------------------------GGQCREYSEEELIGPGFQGLQQVPLQPGQKVYVTYNGREVAGL 96

                         170
                  ....*....|....*
gi 221378595  163 VVKHDATKDEVIVKI 177
Cdd:pfam15997  97 VEQHSWAEDEVTVQL 111
Tudor_ZGPAT cd20384
Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and ...
 13-36 7.75e-03

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410455  Cd Length: 55  Bit Score: 34.51  E-value: 7.75e-03
                         10        20
                 ....*....|....*....|....
gi 221378595  13 IGTKVCAKGPDGLWYSGTISDVKT 36
Cdd:cd20384    7 EGSRCLAKYDDGLWYPATVTDIDE 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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