NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|221475535|ref|NP_001137829|]
View 

miles to go, isoform E [Drosophila melanogaster]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  19576999|9837732|8981327

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1380-1609 1.58e-22

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 104.70  E-value: 1.58e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1380 DLTPGGMYETQVRAINRIGAGSWSQWMRFTAAAAAPGVPEELRVLVKSATHLGVSWQPPlqeNGAPVTSYTLksasqERK 1459
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPV---TESDATGYRV-----YRS 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1460 EDDSE--EEVKEPPSSEFHNcyqgpqtcaelRNLSPYTRYHFRIQASNSAGT-GNSSDVISVCTPAAVPGAPQ-MQGYEF 1535
Cdd:COG3401   270 NSGDGpfTKVATVTTTSYTD-----------TGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSgLTATAV 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1536 TAQEVTLNWTqpAAHGSPICSYNIEYGE------RTIATPDACTRYTVSGLMPETGYKFRVQAVNAIG-AGAFSAYAKLT 1608
Cdd:COG3401   339 GSSSITLSWT--ASSDADVTGYNVYRSTsgggtyTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSAT 416


                  .
gi 221475535 1609 T 1609
Cdd:COG3401   417 T 417
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1037-1124 3.47e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.83  E-value: 3.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1037 KLVSRTKNSINLRWAAPAANGASIQHYLLEYDEgrMPGQPQKFVELAKIKAKHYVIGKLQPTTVYSFRLAAVNEAGQSPY 1116
Cdd:cd00063     8 RVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE--KGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPP 85


                  ....*...
gi 221475535 1117 SPVASYST 1124
Cdd:cd00063    86 SESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1619-1714 9.36e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 9.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1619 LECSGAGHNYIKLKWgengngkvvnSNPSGNGGDFTKYFVEMYVARAKQFQAV--YSGTNCMCKVHKLQERSSYTFRIYA 1696
Cdd:cd00063     7 LRVTDVTSTSVTLSW----------TPPEDDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRA 76

                          90
                  ....*....|....*...
gi 221475535 1697 HTDrAGDGDYSEEFVFET 1714
Cdd:cd00063    77 VNG-GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1221-1312 5.69e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 5.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1221 PGRPGKPHAKGkIHGTQFKARWDAPSDSGGaEILCYHLELSAAGPAFERIYS---GAETEAMCERLQPGTTYALRACCEG 1297
Cdd:cd00063     1 PSPPTNLRVTD-VTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 221475535 1298 PAGQSPYSDIGHVTT 1312
Cdd:cd00063    79 GGGESPPSESVTVTT 93
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
937-1125 2.15e-06

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 52.70  E-value: 2.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535  937 VIDVTSRAAKIIWeSPAIANTVTvdmrqlRYQVLLCDSGKQcKYKSLYQGEAYECIVQDLQPGQDYLVRLQVHYQklTGT 1016
Cdd:COG3401   241 ATADTPGSVTLSW-DPVTESDAT------GYRVYRSNSGDG-PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDA--AGN 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1017 VSDPTEF---RTPPCEPDQPPPPKLVSRTKNSINLRWAAPAANGASiqHYLLEYDEGrmpgQPQKFVELAK-IKAKHYVI 1092
Cdd:COG3401   311 ESAPSNVvsvTTDLTPPAAPSGLTATAVGSSSITLSWTASSDADVT--GYNVYRSTS----GGGTYTKIAEtVTTTSYTD 384

                         170       180       190
                  ....*....|....*....|....*....|....
gi 221475535 1093 GKLQPTTVYSFRLAAVNEAG-QSPYSPVASYSTS 1125
Cdd:COG3401   385 TGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTA 418
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1334-1409 3.27e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.41  E-value: 3.27e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221475535 1334 ALLKLRPPEYNGGaPILEFEAQMRRLEQVQPPQL-VYRGKQTYFVAQDLTPGGMYETQVRAINRIGAGSWSQWMRFT 1409
Cdd:cd00063    17 VTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1149-1216 7.15e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.86  E-value: 7.15e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 221475535 1149 WERRAQDG----DFLLQLQDAETGHGF-LNTYKGTELQTECLQLRRASSYQFRLRSENEAGFSPWSPEVSYRT 1216
Cdd:cd00063    21 WTPPEDDGgpitGYVVEYREKGSGDWKeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1380-1609 1.58e-22

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 104.70  E-value: 1.58e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1380 DLTPGGMYETQVRAINRIGAGSWSQWMRFTAAAAAPGVPEELRVLVKSATHLGVSWQPPlqeNGAPVTSYTLksasqERK 1459
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPV---TESDATGYRV-----YRS 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1460 EDDSE--EEVKEPPSSEFHNcyqgpqtcaelRNLSPYTRYHFRIQASNSAGT-GNSSDVISVCTPAAVPGAPQ-MQGYEF 1535
Cdd:COG3401   270 NSGDGpfTKVATVTTTSYTD-----------TGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSgLTATAV 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1536 TAQEVTLNWTqpAAHGSPICSYNIEYGE------RTIATPDACTRYTVSGLMPETGYKFRVQAVNAIG-AGAFSAYAKLT 1608
Cdd:COG3401   339 GSSSITLSWT--ASSDADVTGYNVYRSTsgggtyTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSAT 416


                  .
gi 221475535 1609 T 1609
Cdd:COG3401   417 T 417
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1415-1520 1.18e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 74.07  E-value: 1.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1415 PGVPEELRVLVKSATHLGVSWQPPlQENGAPVTSYTLksasqERKEDDSEEEVKEPPSSefhncyqGPQTCAELRNLSPY 1494
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPP-EDDGGPITGYVV-----EYREKGSGDWKEVEVTP-------GSETSYTLTGLKPG 67

                          90       100
                  ....*....|....*....|....*.
gi 221475535 1495 TRYHFRIQASNSAGTGNSSDVISVCT 1520
Cdd:cd00063    68 TEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1037-1124 3.47e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.83  E-value: 3.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1037 KLVSRTKNSINLRWAAPAANGASIQHYLLEYDEgrMPGQPQKFVELAKIKAKHYVIGKLQPTTVYSFRLAAVNEAGQSPY 1116
Cdd:cd00063     8 RVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE--KGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPP 85


                  ....*...
gi 221475535 1117 SPVASYST 1124
Cdd:cd00063    86 SESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1415-1510 8.71e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.63  E-value: 8.71e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535   1415 PGVPEELRVLVKSATHLGVSWQPPLQENG-APVTSYTLksasQERKEDDSEEEVKEPPSsefhncyqgpQTCAELRNLSP 1493
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGItGYIVGYRV----EYREEGSEWKEVNVTPS----------STSYTLTGLKP 66

                            90
                    ....*....|....*..
gi 221475535   1494 YTRYHFRIQASNSAGTG 1510
Cdd:smart00060   67 GTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
1418-1513 1.53e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 1.53e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535  1418 PEELRVLVKSATHLGVSWQPPLQENGaPVTSYTLksasqERKEDDSEEEVKEPPSSefhncyqGPQTCAELRNLSPYTRY 1497
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNG-PITGYEV-----EYRPKNSGEPWNEITVP-------GTTTSVTLTGLKPGTEY 69

                           90
                   ....*....|....*.
gi 221475535  1498 HFRIQASNSAGTGNSS 1513
Cdd:pfam00041   70 EVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1037-1114 2.87e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 2.87e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221475535   1037 KLVSRTKNSINLRWAAPAANGasIQHYLLEYDEGRMPGQPQKFVELAKIKAKHYVIGKLQPTTVYSFRLAAVNEAGQS 1114
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPDDG--ITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
1037-1117 1.61e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.57  E-value: 1.61e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535  1037 KLVSRTKNSINLRWAAPAANGASIQHYLLEYDEGRMPGQPQKFVELAkiKAKHYVIGKLQPTTVYSFRLAAVNEAGQSPY 1116
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPG--TTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84


                   .
gi 221475535  1117 S 1117
Cdd:pfam00041   85 S 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1619-1714 9.36e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 9.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1619 LECSGAGHNYIKLKWgengngkvvnSNPSGNGGDFTKYFVEMYVARAKQFQAV--YSGTNCMCKVHKLQERSSYTFRIYA 1696
Cdd:cd00063     7 LRVTDVTSTSVTLSW----------TPPEDDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRA 76

                          90
                  ....*....|....*...
gi 221475535 1697 HTDrAGDGDYSEEFVFET 1714
Cdd:cd00063    77 VNG-GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1221-1312 5.69e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 5.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1221 PGRPGKPHAKGkIHGTQFKARWDAPSDSGGaEILCYHLELSAAGPAFERIYS---GAETEAMCERLQPGTTYALRACCEG 1297
Cdd:cd00063     1 PSPPTNLRVTD-VTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 221475535 1298 PAGQSPYSDIGHVTT 1312
Cdd:cd00063    79 GGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
995-1121 6.92e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 54.24  E-value: 6.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535  995 DLQPGQDYLVRLQVHYQKLTGTVSDPTEFRTPPCEPDQPPPPKLVSRTKNSINLRWAAPAANGASiqHYLLEydegRMPG 1074
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESDAT--GYRVY----RSNS 271

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 221475535 1075 QPQKFVELAKIKAKHYVIGKLQPTTVYSFRLAAVNEAG-QSPYSPVAS 1121
Cdd:COG3401   272 GDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVS 319
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
937-1125 2.15e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 52.70  E-value: 2.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535  937 VIDVTSRAAKIIWeSPAIANTVTvdmrqlRYQVLLCDSGKQcKYKSLYQGEAYECIVQDLQPGQDYLVRLQVHYQklTGT 1016
Cdd:COG3401   241 ATADTPGSVTLSW-DPVTESDAT------GYRVYRSNSGDG-PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDA--AGN 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1017 VSDPTEF---RTPPCEPDQPPPPKLVSRTKNSINLRWAAPAANGASiqHYLLEYDEGrmpgQPQKFVELAK-IKAKHYVI 1092
Cdd:COG3401   311 ESAPSNVvsvTTDLTPPAAPSGLTATAVGSSSITLSWTASSDADVT--GYNVYRSTS----GGGTYTKIAEtVTTTSYTD 384

                         170       180       190
                  ....*....|....*....|....*....|....
gi 221475535 1093 GKLQPTTVYSFRLAAVNEAG-QSPYSPVASYSTS 1125
Cdd:COG3401   385 TGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTA 418
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 930-1025 3.11e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.49  E-value: 3.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535  930 SAIEKPEVIDVTSRAAKIIWESPAIANTvtvdmRQLRYQVLLCDSG-KQCKYKSLYQGEAYECIVQDLQPGQDYLVRLQV 1008
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGG-----PITGYVVEYREKGsGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRA 76

                          90
                  ....*....|....*..
gi 221475535 1009 HYQKLTGTVSDPTEFRT 1025
Cdd:cd00063    77 VNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1334-1409 3.27e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.41  E-value: 3.27e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221475535 1334 ALLKLRPPEYNGGaPILEFEAQMRRLEQVQPPQL-VYRGKQTYFVAQDLTPGGMYETQVRAINRIGAGSWSQWMRFT 1409
Cdd:cd00063    17 VTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1221-1302 4.44e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.06  E-value: 4.44e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535   1221 PGRPGKPHAKGkIHGTQFKARWDAPSDSGG-AEILCYHLELSAAGPAFERIY-SGAETEAMCERLQPGTTYALRACCEGP 1298
Cdd:smart00060    1 PSPPSNLRVTD-VTSTSVTLSWEPPPDDGItGYIVGYRVEYREEGSEWKEVNvTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 221475535   1299 AGQS 1302
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
930-1015 1.81e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.32  E-value: 1.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535   930 SAIEKPEVIDVTSRAAKIIWESPAIANtVTVDMRQLRYQVllCDSGKQCKYKSLyQGEAYECIVQDLQPGQDYLVRLQVH 1009
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGN-GPITGYEVEYRP--KNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*.
gi 221475535  1010 YQKLTG 1015
Cdd:pfam00041   77 NGGGEG 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1339-1400 5.79e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.59  E-value: 5.79e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221475535   1339 RPPEYNGGAPILEFEAQMRRLEQVQPpQLVYRGKQTYFVAQDLTPGGMYETQVRAINRIGAG 1400
Cdd:smart00060   23 PPPDDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
1618-1707 5.96e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.78  E-value: 5.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535  1618 RLECSGAGHNYIKLKWgengngkvvnSNPSGNGGDFTKYFVEMYVARAKQFQAVY--SGTNCMCKVHKLQERSSYTFRIY 1695
Cdd:pfam00041    5 NLTVTDVTSTSLTVSW----------TPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQ 74

                           90
                   ....*....|..
gi 221475535  1696 AHTDrAGDGDYS 1707
Cdd:pfam00041   75 AVNG-GGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 930-1012 6.26e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.59  E-value: 6.26e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535    930 SAIEKPEVIDVTSRAAKIIWESPAIANTVTvdmRQLRYQVLLCDSGKQCKyKSLYQGEAYECIVQDLQPGQDYLVRLQVH 1009
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITG---YIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ...
gi 221475535   1010 YQK 1012
Cdd:smart00060   78 NGA 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1149-1216 7.15e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.86  E-value: 7.15e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 221475535 1149 WERRAQDG----DFLLQLQDAETGHGF-LNTYKGTELQTECLQLRRASSYQFRLRSENEAGFSPWSPEVSYRT 1216
Cdd:cd00063    21 WTPPEDDGgpitGYVVEYREKGSGDWKeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1380-1609 1.58e-22

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 104.70  E-value: 1.58e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1380 DLTPGGMYETQVRAINRIGAGSWSQWMRFTAAAAAPGVPEELRVLVKSATHLGVSWQPPlqeNGAPVTSYTLksasqERK 1459
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPV---TESDATGYRV-----YRS 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1460 EDDSE--EEVKEPPSSEFHNcyqgpqtcaelRNLSPYTRYHFRIQASNSAGT-GNSSDVISVCTPAAVPGAPQ-MQGYEF 1535
Cdd:COG3401   270 NSGDGpfTKVATVTTTSYTD-----------TGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSgLTATAV 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1536 TAQEVTLNWTqpAAHGSPICSYNIEYGE------RTIATPDACTRYTVSGLMPETGYKFRVQAVNAIG-AGAFSAYAKLT 1608
Cdd:COG3401   339 GSSSITLSWT--ASSDADVTGYNVYRSTsgggtyTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSAT 416


                  .
gi 221475535 1609 T 1609
Cdd:COG3401   417 T 417
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1415-1520 1.18e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 74.07  E-value: 1.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1415 PGVPEELRVLVKSATHLGVSWQPPlQENGAPVTSYTLksasqERKEDDSEEEVKEPPSSefhncyqGPQTCAELRNLSPY 1494
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPP-EDDGGPITGYVV-----EYREKGSGDWKEVEVTP-------GSETSYTLTGLKPG 67

                          90       100
                  ....*....|....*....|....*.
gi 221475535 1495 TRYHFRIQASNSAGTGNSSDVISVCT 1520
Cdd:cd00063    68 TEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1037-1124 3.47e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.83  E-value: 3.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1037 KLVSRTKNSINLRWAAPAANGASIQHYLLEYDEgrMPGQPQKFVELAKIKAKHYVIGKLQPTTVYSFRLAAVNEAGQSPY 1116
Cdd:cd00063     8 RVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE--KGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPP 85


                  ....*...
gi 221475535 1117 SPVASYST 1124
Cdd:cd00063    86 SESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1525-1609 1.19e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 1.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1525 PGAPQ-MQGYEFTAQEVTLNWTQPAAHGSPICSYNIEYGERTIATPDAC-------TRYTVSGLMPETGYKFRVQAVNAI 1596
Cdd:cd00063     1 PSPPTnLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVevtpgseTSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 221475535 1597 GAGAFSAYAKLTT 1609
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1415-1510 8.71e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.63  E-value: 8.71e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535   1415 PGVPEELRVLVKSATHLGVSWQPPLQENG-APVTSYTLksasQERKEDDSEEEVKEPPSsefhncyqgpQTCAELRNLSP 1493
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGItGYIVGYRV----EYREEGSEWKEVNVTPS----------STSYTLTGLKP 66

                            90
                    ....*....|....*..
gi 221475535   1494 YTRYHFRIQASNSAGTG 1510
Cdd:smart00060   67 GTEYEFRVRAVNGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1525-1599 1.05e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.63  E-value: 1.05e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535   1525 PGAPQ-MQGYEFTAQEVTLNWTQPA--AHGSPICSYNIEYGE-----RTIATPDACTRYTVSGLMPETGYKFRVQAVNAI 1596
Cdd:smart00060    1 PSPPSnLRVTDVTSTSVTLSWEPPPddGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 221475535   1597 GAG 1599
Cdd:smart00060   81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
1418-1513 1.53e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 1.53e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535  1418 PEELRVLVKSATHLGVSWQPPLQENGaPVTSYTLksasqERKEDDSEEEVKEPPSSefhncyqGPQTCAELRNLSPYTRY 1497
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNG-PITGYEV-----EYRPKNSGEPWNEITVP-------GTTTSVTLTGLKPGTEY 69

                           90
                   ....*....|....*.
gi 221475535  1498 HFRIQASNSAGTGNSS 1513
Cdd:pfam00041   70 EVRVQAVNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
1539-1602 1.66e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 1.66e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221475535  1539 EVTLNWTQPAAHGSPICSYNIEY-------GERTIATPDACTRYTVSGLMPETGYKFRVQAVNAIGAGAFS 1602
Cdd:pfam00041   15 SLTVSWTPPPDGNGPITGYEVEYrpknsgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1357-1605 9.12e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 66.95  E-value: 9.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1357 RRLEQVQPPQLVYRGKQTYFVAQDLTPGGMYETQVRAINRIGAGS-WSQWMRFTAAAAAPGVPEELRVLVKSATHLGVSW 1435
Cdd:COG3401   268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESaPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSW 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1436 QPPLqenGAPVTSYTLKSASqerKEDDSEEEVKEPPSSEFHncyqgpqtcaELRNLSPYTRYHFRIQASNSAGT-GNSSD 1514
Cdd:COG3401   348 TASS---DADVTGYNVYRST---SGGGTYTKIAETVTTTSY----------TDTGLTPGTTYYYKVTAVDAAGNeSAPSE 411

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1515 VISVCTPAAVPGAPQMQGYEFTAQEVTLNWTQPAAHGSPICSYNIEY---GERTIATPDACTRYTV-SGLMPETGYKFRV 1590
Cdd:COG3401   412 EVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLadgGDTGNAVPFTTTSSTVtATTTDTTTANLSV 491

                         250
                  ....*....|....*
gi 221475535 1591 QAVNAIGAGAFSAYA 1605
Cdd:COG3401   492 TTGSLVGGSGASSVT 506
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1037-1114 2.87e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 2.87e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221475535   1037 KLVSRTKNSINLRWAAPAANGasIQHYLLEYDEGRMPGQPQKFVELAKIKAKHYVIGKLQPTTVYSFRLAAVNEAGQS 1114
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPDDG--ITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
1037-1117 1.61e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.57  E-value: 1.61e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535  1037 KLVSRTKNSINLRWAAPAANGASIQHYLLEYDEGRMPGQPQKFVELAkiKAKHYVIGKLQPTTVYSFRLAAVNEAGQSPY 1116
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPG--TTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84


                   .
gi 221475535  1117 S 1117
Cdd:pfam00041   85 S 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1619-1714 9.36e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 9.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1619 LECSGAGHNYIKLKWgengngkvvnSNPSGNGGDFTKYFVEMYVARAKQFQAV--YSGTNCMCKVHKLQERSSYTFRIYA 1696
Cdd:cd00063     7 LRVTDVTSTSVTLSW----------TPPEDDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRA 76

                          90
                  ....*....|....*...
gi 221475535 1697 HTDrAGDGDYSEEFVFET 1714
Cdd:cd00063    77 VNG-GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1221-1312 5.69e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 5.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1221 PGRPGKPHAKGkIHGTQFKARWDAPSDSGGaEILCYHLELSAAGPAFERIYS---GAETEAMCERLQPGTTYALRACCEG 1297
Cdd:cd00063     1 PSPPTNLRVTD-VTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 221475535 1298 PAGQSPYSDIGHVTT 1312
Cdd:cd00063    79 GGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
995-1121 6.92e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 54.24  E-value: 6.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535  995 DLQPGQDYLVRLQVHYQKLTGTVSDPTEFRTPPCEPDQPPPPKLVSRTKNSINLRWAAPAANGASiqHYLLEydegRMPG 1074
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESDAT--GYRVY----RSNS 271

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 221475535 1075 QPQKFVELAKIKAKHYVIGKLQPTTVYSFRLAAVNEAG-QSPYSPVAS 1121
Cdd:COG3401   272 GDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVS 319
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
937-1125 2.15e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 52.70  E-value: 2.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535  937 VIDVTSRAAKIIWeSPAIANTVTvdmrqlRYQVLLCDSGKQcKYKSLYQGEAYECIVQDLQPGQDYLVRLQVHYQklTGT 1016
Cdd:COG3401   241 ATADTPGSVTLSW-DPVTESDAT------GYRVYRSNSGDG-PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDA--AGN 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1017 VSDPTEF---RTPPCEPDQPPPPKLVSRTKNSINLRWAAPAANGASiqHYLLEYDEGrmpgQPQKFVELAK-IKAKHYVI 1092
Cdd:COG3401   311 ESAPSNVvsvTTDLTPPAAPSGLTATAVGSSSITLSWTASSDADVT--GYNVYRSTS----GGGTYTKIAEtVTTTSYTD 384

                         170       180       190
                  ....*....|....*....|....*....|....
gi 221475535 1093 GKLQPTTVYSFRLAAVNEAG-QSPYSPVASYSTS 1125
Cdd:COG3401   385 TGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTA 418
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 930-1025 3.11e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.49  E-value: 3.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535  930 SAIEKPEVIDVTSRAAKIIWESPAIANTvtvdmRQLRYQVLLCDSG-KQCKYKSLYQGEAYECIVQDLQPGQDYLVRLQV 1008
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGG-----PITGYVVEYREKGsGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRA 76

                          90
                  ....*....|....*..
gi 221475535 1009 HYQKLTGTVSDPTEFRT 1025
Cdd:cd00063    77 VNGGGESPPSESVTVTT 93
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1433-1609 1.80e-05

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 49.94  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1433 VSWQPPlqengAPVTSYTLksasQERKEDDS--EEEVKEPPSSEFHNCYQGpqtcaelrnlspytRYHFRIQASNSAGTG 1510
Cdd:COG4733   556 VSWDAP-----AGAVAYEV----EWRRDDGNwvSVPRTSGTSFEVPGIYAG--------------DYEVRVRAINALGVS 612

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1511 nSSDVISVCTP----AAVPGAPQmqgyEFTAQ----EVTLNWTQPAahGSPICSYNIEYGERT-------IATPDACTRY 1575
Cdd:COG4733   613 -SAWAASSETTvtgkTAPPPAPT----GLTATgglgGITLSWSFPV--DADTLRTEIRYSTTGdwasatvAQALYPGNTY 685

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 221475535 1576 TVSGLMPETGYKFRVQAVNAIG-AGAFSAYAKLTT 1609
Cdd:COG4733   686 TLAGLKAGQTYYYRARAVDRSGnVSAWWVSGQASA 720
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 1418-1520 2.21e-05

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 44.71  E-value: 2.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535  1418 PEELRV-LVKSATHLGVSWQPPLQENGaPVTSYTLKSASQERKEDDSEEEVKEPpssefhNCYQGPQTCAELRNLSPYTR 1496
Cdd:pfam16656    1 PEQVHLsLTGDSTSMTVSWVTPSAVTS-PVVQYGTSSSALTSTATATSSTYTTG------DGGTGYIHRATLTGLEPGTT 73

                           90       100
                   ....*....|....*....|....
gi 221475535  1497 YHFRIqasnSAGTGNSSDVISVCT 1520
Cdd:pfam16656   74 YYYRV----GDDNGGWSEVYSFTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1334-1409 3.27e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.41  E-value: 3.27e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221475535 1334 ALLKLRPPEYNGGaPILEFEAQMRRLEQVQPPQL-VYRGKQTYFVAQDLTPGGMYETQVRAINRIGAGSWSQWMRFT 1409
Cdd:cd00063    17 VTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVT 92
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1490-1852 3.46e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.85  E-value: 3.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1490 NLSPYTRYHFRIQASNSAGTGNSSDVISVCTPAAVPGAPQ-MQGYEFTAQEVTLNWTqpAAHGSPICSYNIEYGE----- 1563
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTgLTATADTPGSVTLSWD--PVTESDATGYRVYRSNsgdgp 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1564 -RTIATPDAcTRYTVSGLMPETGYKFRVQAVNAIG-AGAFSAYAKLTTQPAPPAPPR-LECSGAGHNYIKLKWGENGngk 1640
Cdd:COG3401   276 fTKVATVTT-TSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSgLTATAVGSSSITLSWTASS--- 351

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1641 vvnsnpsgnGGDFTKYfvemyvarakqfqavysgtncmckvhklqerssytfRIYahtdRAGDGDYSEEFVFETSATlpa 1720
Cdd:COG3401   352 ---------DADVTGY------------------------------------NVY----RSTSGGGTYTKIAETVTT--- 379

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535 1721 nikpprvvqegsvclmelpgqlgmqltlewqhsknsfndrveyelqyavlgaaelegeslspkgrsssssgssngapinl 1800
Cdd:COG3401       --------------------------------------------------------------------------------

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 221475535 1801 pnhdyrqlyrgpeTKFTIDNLAAGTCYQFRVcpvrIAAGGELLYGQPSSPLR 1852
Cdd:COG3401   380 -------------TSYTDTGLTPGTTYYYKV----TAVDAAGNESAPSEEVS 414
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1221-1302 4.44e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.06  E-value: 4.44e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535   1221 PGRPGKPHAKGkIHGTQFKARWDAPSDSGG-AEILCYHLELSAAGPAFERIY-SGAETEAMCERLQPGTTYALRACCEGP 1298
Cdd:smart00060    1 PSPPSNLRVTD-VTSTSVTLSWEPPPDDGItGYIVGYRVEYREEGSEWKEVNvTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 221475535   1299 AGQS 1302
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
930-1015 1.81e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.32  E-value: 1.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535   930 SAIEKPEVIDVTSRAAKIIWESPAIANtVTVDMRQLRYQVllCDSGKQCKYKSLyQGEAYECIVQDLQPGQDYLVRLQVH 1009
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGN-GPITGYEVEYRP--KNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*.
gi 221475535  1010 YQKLTG 1015
Cdd:pfam00041   77 NGGGEG 82
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
1536-1597 1.89e-03

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 42.84  E-value: 1.89e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221475535 1536 TAQEVTLNWTqPAAHGSPICSYNIEYGERTIATPDACTRYTVSGLMPETGYKFRVQAVNAIG 1597
Cdd:COG3979    15 TSSSVSLSWD-ASTDNVGVTGYDVYRGGDQVATVTGLTAWTVTGLTPGTEYTFTVGACDAAG 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1339-1400 5.79e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.59  E-value: 5.79e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221475535   1339 RPPEYNGGAPILEFEAQMRRLEQVQPpQLVYRGKQTYFVAQDLTPGGMYETQVRAINRIGAG 1400
Cdd:smart00060   23 PPPDDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
1618-1707 5.96e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.78  E-value: 5.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535  1618 RLECSGAGHNYIKLKWgengngkvvnSNPSGNGGDFTKYFVEMYVARAKQFQAVY--SGTNCMCKVHKLQERSSYTFRIY 1695
Cdd:pfam00041    5 NLTVTDVTSTSLTVSW----------TPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQ 74

                           90
                   ....*....|..
gi 221475535  1696 AHTDrAGDGDYS 1707
Cdd:pfam00041   75 AVNG-GGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 930-1012 6.26e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.59  E-value: 6.26e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221475535    930 SAIEKPEVIDVTSRAAKIIWESPAIANTVTvdmRQLRYQVLLCDSGKQCKyKSLYQGEAYECIVQDLQPGQDYLVRLQVH 1009
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITG---YIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ...
gi 221475535   1010 YQK 1012
Cdd:smart00060   78 NGA 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1149-1216 7.15e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.86  E-value: 7.15e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 221475535 1149 WERRAQDG----DFLLQLQDAETGHGF-LNTYKGTELQTECLQLRRASSYQFRLRSENEAGFSPWSPEVSYRT 1216
Cdd:cd00063    21 WTPPEDDGgpitGYVVEYREKGSGDWKeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH