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Conserved domains on  [gi|221330261|ref|NP_001137669|]
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I[[h]] channel, isoform H [Drosophila melanogaster]

Protein Classification

ion transporter; potassium channel protein( domain architecture ID 12091564)

ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium across cell membranes| potassium channel protein spans the cell membrane to form a conduction pathway or pore, through which potassium ions diffuse according to their electrochemical gradient

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans_N pfam08412
Ion transport protein N-terminal; This metazoan domain is found to the N-terminus of pfam00520 ...
 709-751 2.54e-22

Ion transport protein N-terminal; This metazoan domain is found to the N-terminus of pfam00520 in voltage- and cyclic nucleotide-gated K/Na ion channels.


:

Pssm-ID: 400630  Cd Length: 43  Bit Score: 90.44  E-value: 2.54e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 221330261  709 LQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSS 751
Cdd:pfam08412   1 LKSLLQPSDNKLSMKLFGSKKAVEKEKERQKEAGVWIIHPCSN 43
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 753-880 3.42e-11

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 64.21  E-value: 3.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330261  753 RFYWDLCMLLLLVANLIILPVAISF-FNDDLSTRWIAFNCLSDTIFLIDIVVNFRTgimqqdnaeqviLDPKliaKHYLR 831
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFqPEEPLTTVLEILDYVFTGIFTLEMLLKIIA------------AGFK---KRYFR 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 221330261  832 T-WFFLDLISSIPLDYIFLIfnqimklqDFSDSFQILHAGRALRILRLAK 880
Cdd:pfam00520  66 SpWNILDFVVVLPSLISLVL--------SSVGSLSGLRVLRLLRLLRLLR 107
 
Name Accession Description Interval E-value
Ion_trans_N pfam08412
Ion transport protein N-terminal; This metazoan domain is found to the N-terminus of pfam00520 ...
 709-751 2.54e-22

Ion transport protein N-terminal; This metazoan domain is found to the N-terminus of pfam00520 in voltage- and cyclic nucleotide-gated K/Na ion channels.


Pssm-ID: 400630  Cd Length: 43  Bit Score: 90.44  E-value: 2.54e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 221330261  709 LQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSS 751
Cdd:pfam08412   1 LKSLLQPSDNKLSMKLFGSKKAVEKEKERQKEAGVWIIHPCSN 43
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 753-880 3.42e-11

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 64.21  E-value: 3.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330261  753 RFYWDLCMLLLLVANLIILPVAISF-FNDDLSTRWIAFNCLSDTIFLIDIVVNFRTgimqqdnaeqviLDPKliaKHYLR 831
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFqPEEPLTTVLEILDYVFTGIFTLEMLLKIIA------------AGFK---KRYFR 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 221330261  832 T-WFFLDLISSIPLDYIFLIfnqimklqDFSDSFQILHAGRALRILRLAK 880
Cdd:pfam00520  66 SpWNILDFVVVLPSLISLVL--------SSVGSLSGLRVLRLLRLLRLLR 107
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 741-845 7.18e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 62.96  E-value: 7.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330261 741 SGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMqqDNAEQVIL 820
Cdd:PLN03192  49 SDGWIISPMDSRYRWWETLMVVLVAYSAWVYPFEVAFLNASPKRGLEIADNVVDLFFAVDIVLTFFVAYI--DPRTQLLV 126

                         90       100
                 ....*....|....*....|....*.
gi 221330261 821 -DPKLIAKHYLRTWFFLDLISSIPLD 845
Cdd:PLN03192 127 rDRKKIAVRYLSTWFLMDVASTIPFQ 152
 
Name Accession Description Interval E-value
Ion_trans_N pfam08412
Ion transport protein N-terminal; This metazoan domain is found to the N-terminus of pfam00520 ...
 709-751 2.54e-22

Ion transport protein N-terminal; This metazoan domain is found to the N-terminus of pfam00520 in voltage- and cyclic nucleotide-gated K/Na ion channels.


Pssm-ID: 400630  Cd Length: 43  Bit Score: 90.44  E-value: 2.54e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 221330261  709 LQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSS 751
Cdd:pfam08412   1 LKSLLQPSDNKLSMKLFGSKKAVEKEKERQKEAGVWIIHPCSN 43
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 753-880 3.42e-11

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 64.21  E-value: 3.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330261  753 RFYWDLCMLLLLVANLIILPVAISF-FNDDLSTRWIAFNCLSDTIFLIDIVVNFRTgimqqdnaeqviLDPKliaKHYLR 831
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFqPEEPLTTVLEILDYVFTGIFTLEMLLKIIA------------AGFK---KRYFR 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 221330261  832 T-WFFLDLISSIPLDYIFLIfnqimklqDFSDSFQILHAGRALRILRLAK 880
Cdd:pfam00520  66 SpWNILDFVVVLPSLISLVL--------SSVGSLSGLRVLRLLRLLRLLR 107
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 741-845 7.18e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 62.96  E-value: 7.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330261 741 SGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMqqDNAEQVIL 820
Cdd:PLN03192  49 SDGWIISPMDSRYRWWETLMVVLVAYSAWVYPFEVAFLNASPKRGLEIADNVVDLFFAVDIVLTFFVAYI--DPRTQLLV 126

                         90       100
                 ....*....|....*....|....*.
gi 221330261 821 -DPKLIAKHYLRTWFFLDLISSIPLD 845
Cdd:PLN03192 127 rDRKKIAVRYLSTWFLMDVASTIPFQ 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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