NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|221330065|ref|NP_001137620|]
View 

Calcium-independent receptor for alpha-latrotoxin, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
7tmB2_CELSR_Adhesion_IV cd15441
cadherin EGF LAG seven-pass G-type receptors, group IV adhesion GPCRs, member of the class B2 ...
695-967 1.55e-95

cadherin EGF LAG seven-pass G-type receptors, group IV adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. Celsr3 is expressed in both the developing and adult mouse brain. It has been functionally implicated in proper neuron migration and axon guidance in the CNS.


:

Pssm-ID: 320557 [Multi-domain]  Cd Length: 254  Bit Score: 308.80  E-value: 1.55e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  695 DGNMRIFIYISIGICVVFIVIALLTLKLFNGVfvKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAI 774
Cdd:cd15441     1 VLLLKIVTYIGIGISLVLLVIAFLVLSCLRGL--QSNSNSIHKNLVACLLLAELLFLLGINQTENLFPCKLIAILLHYFY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  775 LSGTAWFCYEAFHSYSTLTSDELllevDQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMeANALFYATFVI 854
Cdd:cd15441    79 LSAFSWLLVESLHLYRMLTEPRD----INHGHMRFYYLLGYGIPAIIVGLSVGLRPDGYGNPDFCWLS-VNETLIWSFAG 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  855 PVLVFFVAAIGYTFLSWIIMCRKSRTGLKtkehtrLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAkmdddtADVYGYC 934
Cdd:cd15441   154 PIAFVIVITLIIFILALRASCTLKRHVLE------KASVRTDLRSSFLLLPLLGATWVFGLLAVNED------SELLHYL 221
                         250       260       270
                  ....*....|....*....|....*....|...
gi 221330065  935 FICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQ 967
Cdd:cd15441   222 FAGLNFLQGLFIFLFYCIFNKKVRRELKNALLR 254
GAIN pfam16489
GPCR-Autoproteolysis INducing (GAIN) domain; The GAIN a domain of alpha-helices and ...
383-614 2.93e-44

GPCR-Autoproteolysis INducing (GAIN) domain; The GAIN a domain of alpha-helices and beta-strands that is found in cell-adhesion GPCRs and precedes the GPS motif where the autoproteolysis occurs, family, pfam01825. The full GAIN domain, comprises the GPS and the GAIN, in cell-adhesion GPCRs, and is the functional unit for autoproteolysis. The GPS motif at the end of the GAIN domain is an ancient domain that exists in primitive ancestor organizms, and the full GAIN + GPS is conserved in all cell-adhesion GPCRs and all PKD1-related proteins.


:

Pssm-ID: 465137  Cd Length: 205  Bit Score: 159.74  E-value: 2.93e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065   383 SLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMmhdketfpdQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDL 462
Cdd:pfam16489    1 GAKELARELRNATRHGPLYGGDVLTAVELLSQLFDLL---------ATQDATLSNAFLENFVQTVSNLLDPENRESWEDL 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065   463 NPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVV--FPDSDQWPLSSDRIELPRAAL 540
Cdd:pfam16489   72 QQTERGTAATKLLRTLEEYALLLAQNMKYLTPFTIVTPNIVLSVDRLDTHNFKGARFprFPMKGERPKDEDSVKLPPKAF 151
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221330065   541 IDNSEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYVRntailsndsdvnageiqqrlRILNSKVISASLGK 614
Cdd:pfam16489  152 KPPDSNGTVVVVFILYRNLGSLLPPSSRYDPDRRSLRLPR--------------------RVVNSPVVSASVHS 205
Gal_Rha_Lectin super family cl45893
Galactose/rhamnose-binding lectin domain; Galactose/rhamnose-binding lectin domain is formed ...
1-45 5.68e-21

Galactose/rhamnose-binding lectin domain; Galactose/rhamnose-binding lectin domain is formed from a four-stranded antiparallel beta-sheet which packs against an alpha-helix. It was originally described as galactose-binding lectin domain since it was found in a galactose-binding sea urchin egg lectin (SUEL). SUEL was first isolated as a D-galactoside binding lectin, it was later shown that it binds to L-rhamnose preferentially. Galactose/rhamnose-binding lectin domain is also found in many rhamnose-binding lectins, such as Oncorhynchus keta L-rhamnose-binding lectins (CSLs) and Silurus asotus rhamnose-binding lectin (SAL). In addition, the superfamily includes many SUEL/CSLs/SAL homologous proteins, such as plant beta-galactosidases, mammalian latrophilins, Caenorhabditis elegans protein EVA-1 and its homolog, human protein EVA-1 homolog C (also known as C21orf63). Due to the lack of galactose/rhamnose-binding key residues, some superfamily members may not form a binding pocket for galactose/rhamnose. Therefore, they are unlikely to act as galactose/rhamnose-binding lectins.


The actual alignment was detected with superfamily member cd22830:

Pssm-ID: 459238 [Multi-domain]  Cd Length: 92  Bit Score: 88.83  E-value: 5.68e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 221330065    1 MFPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQC 45
Cdd:cd22830    48 MSPRSLRVVQERCDGKRSCSIPASSSVFGDPCPGTPKYLEVHYQC 92
GPS smart00303
G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin ...
637-684 6.60e-19

G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin REJ and polycystin.


:

Pssm-ID: 197639  Cd Length: 49  Bit Score: 81.66  E-value: 6.60e-19
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 221330065    637 TNPTCVFWNYIDHAWSANGCSLESTNRTHSVCSCNHLTNFAILMDVVD 684
Cdd:smart00303    1 FNPICVFWDESSGEWSTRGCELLETNGTHTTCSCNHLTTFAVLMDVPP 48
Herpes_TAF50 super family cl25754
Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 ...
1151-1297 1.63e-03

Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.


The actual alignment was detected with superfamily member pfam03326:

Pssm-ID: 308764 [Multi-domain]  Cd Length: 568  Bit Score: 43.15  E-value: 1.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  1151 ASSPQQAHEVFYWT--QKPNSGHNGKKKRGAGGVPASPSGSLHSRTAAAS------QVLFYPSYKKTKPGQPTGYPQYAE 1222
Cdd:pfam03326  358 ATAHQESDQRPIGPgpEKPTFLPPVGGKQFFQGLRDSRSTSFLTAPEATSaisdvfQGTEVCQPKRIRALHPPGSPSANR 437
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221330065  1223 ALDPPLA-TGNAAAYYQQQQQLRRQQLHQQQQQQQQQQLSSDEEQAEQHAHLLHLQRRAG--SQQQLPAPPPHMAQYQ 1297
Cdd:pfam03326  438 PLPSSLApTPTGPVHEPGSSLTPATVPQPLDAAPVATPEASHELQPPDEETPQPLDEDQAlcGQQDASHPPPRGQLDE 515
 
Name Accession Description Interval E-value
7tmB2_CELSR_Adhesion_IV cd15441
cadherin EGF LAG seven-pass G-type receptors, group IV adhesion GPCRs, member of the class B2 ...
695-967 1.55e-95

cadherin EGF LAG seven-pass G-type receptors, group IV adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. Celsr3 is expressed in both the developing and adult mouse brain. It has been functionally implicated in proper neuron migration and axon guidance in the CNS.


Pssm-ID: 320557 [Multi-domain]  Cd Length: 254  Bit Score: 308.80  E-value: 1.55e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  695 DGNMRIFIYISIGICVVFIVIALLTLKLFNGVfvKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAI 774
Cdd:cd15441     1 VLLLKIVTYIGIGISLVLLVIAFLVLSCLRGL--QSNSNSIHKNLVACLLLAELLFLLGINQTENLFPCKLIAILLHYFY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  775 LSGTAWFCYEAFHSYSTLTSDELllevDQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMeANALFYATFVI 854
Cdd:cd15441    79 LSAFSWLLVESLHLYRMLTEPRD----INHGHMRFYYLLGYGIPAIIVGLSVGLRPDGYGNPDFCWLS-VNETLIWSFAG 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  855 PVLVFFVAAIGYTFLSWIIMCRKSRTGLKtkehtrLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAkmdddtADVYGYC 934
Cdd:cd15441   154 PIAFVIVITLIIFILALRASCTLKRHVLE------KASVRTDLRSSFLLLPLLGATWVFGLLAVNED------SELLHYL 221
                         250       260       270
                  ....*....|....*....|....*....|...
gi 221330065  935 FICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQ 967
Cdd:cd15441   222 FAGLNFLQGLFIFLFYCIFNKKVRRELKNALLR 254
GAIN pfam16489
GPCR-Autoproteolysis INducing (GAIN) domain; The GAIN a domain of alpha-helices and ...
383-614 2.93e-44

GPCR-Autoproteolysis INducing (GAIN) domain; The GAIN a domain of alpha-helices and beta-strands that is found in cell-adhesion GPCRs and precedes the GPS motif where the autoproteolysis occurs, family, pfam01825. The full GAIN domain, comprises the GPS and the GAIN, in cell-adhesion GPCRs, and is the functional unit for autoproteolysis. The GPS motif at the end of the GAIN domain is an ancient domain that exists in primitive ancestor organizms, and the full GAIN + GPS is conserved in all cell-adhesion GPCRs and all PKD1-related proteins.


Pssm-ID: 465137  Cd Length: 205  Bit Score: 159.74  E-value: 2.93e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065   383 SLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMmhdketfpdQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDL 462
Cdd:pfam16489    1 GAKELARELRNATRHGPLYGGDVLTAVELLSQLFDLL---------ATQDATLSNAFLENFVQTVSNLLDPENRESWEDL 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065   463 NPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVV--FPDSDQWPLSSDRIELPRAAL 540
Cdd:pfam16489   72 QQTERGTAATKLLRTLEEYALLLAQNMKYLTPFTIVTPNIVLSVDRLDTHNFKGARFprFPMKGERPKDEDSVKLPPKAF 151
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221330065   541 IDNSEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYVRntailsndsdvnageiqqrlRILNSKVISASLGK 614
Cdd:pfam16489  152 KPPDSNGTVVVVFILYRNLGSLLPPSSRYDPDRRSLRLPR--------------------RVVNSPVVSASVHS 205
Gal_Rha_Lectin_dCirl cd22830
galactose/rhamnose binding lectin domain found in Drosophila melanogaster Latrophilin Cirl and ...
1-45 5.68e-21

galactose/rhamnose binding lectin domain found in Drosophila melanogaster Latrophilin Cirl and similar proteins; Latrophilin Cirl (calcium-independent receptor for latrotoxin) is an adhesion-type G-protein-coupled receptor (aGPCR) that acts as a molecular sensor and signal transducer that detects and converts mechanical stimuli into a metabotropic response. It functions in mechanosensory neurons by modulating ionotropic receptor currents, the initiating step of cellular mechanosensation. The model corresponds to a galactose/rhamnose-binding lectin domain found at the N-terminus of Latrophilin Cirl.


Pssm-ID: 438687 [Multi-domain]  Cd Length: 92  Bit Score: 88.83  E-value: 5.68e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 221330065    1 MFPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQC 45
Cdd:cd22830    48 MSPRSLRVVQERCDGKRSCSIPASSSVFGDPCPGTPKYLEVHYQC 92
7tm_2 pfam00002
7 transmembrane receptor (Secretin family); This family is known as Family B, the ...
695-946 3.45e-19

7 transmembrane receptor (Secretin family); This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs). They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteriztic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.


Pssm-ID: 459625 [Multi-domain]  Cd Length: 248  Bit Score: 88.88  E-value: 3.45e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065   695 DGNMRIFIYISIGICVVFIVIALLTLKLFNGVfvKSARTSIYTSIYLCLLAIELLFLLGIEQTETS--------IFCGFI 766
Cdd:pfam00002    1 ALSLKVIYTVGYSLSLVALLLAIAIFLLFRKL--HCTRNYIHLNLFASFILRALLFLVGDAVLFNKqdldhcswVGCKVV 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065   767 TIFLHCAILSGTAWFCYEAFHSYStltsdeLLLEV--DQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEA 844
Cdd:pfam00002   79 AVFLHYFFLANFFWMLVEGLYLYT------LLVEVffSERKYFWWYLLIGWGVPALVVGIWAGVDPKGYGEDDGCWLSNE 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065   845 NALFYaTFVIPVLVFFVaaIGYTFLSWI--IMCRKSRTglKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRgak 922
Cdd:pfam00002  153 NGLWW-IIRGPILLIIL--VNFIIFINIvrILVQKLRE--TNMGKSDLKQYRRLAKSTLLLLPLLGITWVFGLFAFN--- 224
                          250       260
                   ....*....|....*....|....
gi 221330065   923 MDDDTADVYGYCFICFNTLLGLYI 946
Cdd:pfam00002  225 PENTLRVVFLYLFLILNSFQGFFV 248
GPS smart00303
G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin ...
637-684 6.60e-19

G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin REJ and polycystin.


Pssm-ID: 197639  Cd Length: 49  Bit Score: 81.66  E-value: 6.60e-19
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 221330065    637 TNPTCVFWNYIDHAWSANGCSLESTNRTHSVCSCNHLTNFAILMDVVD 684
Cdd:smart00303    1 FNPICVFWDESSGEWSTRGCELLETNGTHTTCSCNHLTTFAVLMDVPP 48
GPS pfam01825
GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for ...
639-679 1.79e-17

GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for auto-proteolysis, so is thus named, GPS. The GPS motif is a conserved sequence of ~40 amino acids containing canonical cysteine and tryptophan residues, and is the most highly conserved part of the domain. In most, if not all, cell-adhesion GPCRs these undergo autoproteolysis in the GPS between a conserved aliphatic residue (usually a leucine) and a threonine, serine, or cysteine residue. In higher eukaryotes this motif is found embedded in the C-terminal beta-stranded part of a GAIN domain - GPCR-Autoproteolysis INducing (GAIN). The GAIN-GPS domain adopts a fold in which the GPS motif, at the C-terminus, forms five beta-strands that are tightly integrated into the overall GAIN domain. The GPS motif, evolutionarily conserved from tetrahymena to mammals, is the only extracellular domain shared by all human cell-adhesion GPCRs and PKD proteins, and is the locus of multiple human disease mutations. The GAIN-GPS domain is both necessary and sufficient functionally for autoproteolysis, suggesting an autoproteolytic mechanism whereby the overall GAIN domain fine-tunes the chemical environment in the GPS to catalyze peptide bond hydrolysis. In the cell-adhesion GPCRs and PKD proteins, the GPS motif is always located at the end of their long N-terminal extracellular regions, immediately before the first transmembrane helix of the respective protein.


Pssm-ID: 460350  Cd Length: 44  Bit Score: 77.35  E-value: 1.79e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 221330065   639 PTCVFWNYIDH---AWSANGCSLESTNRTHSVCSCNHLTNFAIL 679
Cdd:pfam01825    1 PQCVFWDFTNSttgRWSTEGCTTVSLNDTHTVCSCNHLTSFAVL 44
Gal_Lectin pfam02140
Galactose binding lectin domain;
2-45 9.77e-13

Galactose binding lectin domain;


Pssm-ID: 460460 [Multi-domain]  Cd Length: 79  Bit Score: 65.00  E-value: 9.77e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 221330065     2 FPKSLSVLNSRCAHKQSCGVLAATSMFG-DPCPGTHKYLEAHYQC 45
Cdd:pfam02140   35 SPNSLAIVSKACQGKNSCSVPASNSVFGgDPCPGTYKYLEVEYKC 79
Herpes_TAF50 pfam03326
Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 ...
1151-1297 1.63e-03

Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.


Pssm-ID: 308764 [Multi-domain]  Cd Length: 568  Bit Score: 43.15  E-value: 1.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  1151 ASSPQQAHEVFYWT--QKPNSGHNGKKKRGAGGVPASPSGSLHSRTAAAS------QVLFYPSYKKTKPGQPTGYPQYAE 1222
Cdd:pfam03326  358 ATAHQESDQRPIGPgpEKPTFLPPVGGKQFFQGLRDSRSTSFLTAPEATSaisdvfQGTEVCQPKRIRALHPPGSPSANR 437
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221330065  1223 ALDPPLA-TGNAAAYYQQQQQLRRQQLHQQQQQQQQQQLSSDEEQAEQHAHLLHLQRRAG--SQQQLPAPPPHMAQYQ 1297
Cdd:pfam03326  438 PLPSSLApTPTGPVHEPGSSLTPATVPQPLDAAPVATPEASHELQPPDEETPQPLDEDQAlcGQQDASHPPPRGQLDE 515
PLN03059 PLN03059
beta-galactosidase; Provisional
4-45 2.71e-03

beta-galactosidase; Provisional


Pssm-ID: 166698 [Multi-domain]  Cd Length: 840  Bit Score: 42.68  E-value: 2.71e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 221330065    4 KSLSVLNSRCAHKQSCGVLAATSMF-GDPCPGTHKYLEAHYQC 45
Cdd:PLN03059  797 KSYDAFERNCIGKQSCSVTVAPEVFgGDPCPDSMKKLSVEAVC 839
 
Name Accession Description Interval E-value
7tmB2_CELSR_Adhesion_IV cd15441
cadherin EGF LAG seven-pass G-type receptors, group IV adhesion GPCRs, member of the class B2 ...
695-967 1.55e-95

cadherin EGF LAG seven-pass G-type receptors, group IV adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. Celsr3 is expressed in both the developing and adult mouse brain. It has been functionally implicated in proper neuron migration and axon guidance in the CNS.


Pssm-ID: 320557 [Multi-domain]  Cd Length: 254  Bit Score: 308.80  E-value: 1.55e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  695 DGNMRIFIYISIGICVVFIVIALLTLKLFNGVfvKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAI 774
Cdd:cd15441     1 VLLLKIVTYIGIGISLVLLVIAFLVLSCLRGL--QSNSNSIHKNLVACLLLAELLFLLGINQTENLFPCKLIAILLHYFY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  775 LSGTAWFCYEAFHSYSTLTSDELllevDQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMeANALFYATFVI 854
Cdd:cd15441    79 LSAFSWLLVESLHLYRMLTEPRD----INHGHMRFYYLLGYGIPAIIVGLSVGLRPDGYGNPDFCWLS-VNETLIWSFAG 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  855 PVLVFFVAAIGYTFLSWIIMCRKSRTGLKtkehtrLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAkmdddtADVYGYC 934
Cdd:cd15441   154 PIAFVIVITLIIFILALRASCTLKRHVLE------KASVRTDLRSSFLLLPLLGATWVFGLLAVNED------SELLHYL 221
                         250       260       270
                  ....*....|....*....|....*....|...
gi 221330065  935 FICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQ 967
Cdd:cd15441   222 FAGLNFLQGLFIFLFYCIFNKKVRRELKNALLR 254
GAIN pfam16489
GPCR-Autoproteolysis INducing (GAIN) domain; The GAIN a domain of alpha-helices and ...
383-614 2.93e-44

GPCR-Autoproteolysis INducing (GAIN) domain; The GAIN a domain of alpha-helices and beta-strands that is found in cell-adhesion GPCRs and precedes the GPS motif where the autoproteolysis occurs, family, pfam01825. The full GAIN domain, comprises the GPS and the GAIN, in cell-adhesion GPCRs, and is the functional unit for autoproteolysis. The GPS motif at the end of the GAIN domain is an ancient domain that exists in primitive ancestor organizms, and the full GAIN + GPS is conserved in all cell-adhesion GPCRs and all PKD1-related proteins.


Pssm-ID: 465137  Cd Length: 205  Bit Score: 159.74  E-value: 2.93e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065   383 SLISIANDMSEVTSSKTLYGGDMLVTTKIIQTVSEKMmhdketfpdQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDL 462
Cdd:pfam16489    1 GAKELARELRNATRHGPLYGGDVLTAVELLSQLFDLL---------ATQDATLSNAFLENFVQTVSNLLDPENRESWEDL 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065   463 NPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVV--FPDSDQWPLSSDRIELPRAAL 540
Cdd:pfam16489   72 QQTERGTAATKLLRTLEEYALLLAQNMKYLTPFTIVTPNIVLSVDRLDTHNFKGARFprFPMKGERPKDEDSVKLPPKAF 151
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221330065   541 IDNSEGGLVRIVFAAFDRLESILKPSYDHFDLKSSRSYVRntailsndsdvnageiqqrlRILNSKVISASLGK 614
Cdd:pfam16489  152 KPPDSNGTVVVVFILYRNLGSLLPPSSRYDPDRRSLRLPR--------------------RVVNSPVVSASVHS 205
7tmB2_latrophilin-like_invertebrate cd15440
invertebrate latrophilin-like receptors, member of the class B2 family of seven-transmembrane ...
698-966 6.89e-42

invertebrate latrophilin-like receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors; This subgroup includes latrophilin-like proteins that are found in invertebrates such as insects and worms. Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of vertebrate latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320556 [Multi-domain]  Cd Length: 259  Bit Score: 155.11  E-value: 6.89e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  698 MRIFIYISIGICVVFIVIALLTLKLFNGVfvKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSG 777
Cdd:cd15440     4 LTFITYIGCIISIVCLLLAFITFTCFRNL--QCDRNTIHKNLCLCLLIAEIVFLLGIDQTENRTLCGVIAGLLHYFFLAA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  778 TAWFCYEAFHSYStltsdeLLLEV--DQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYAtFVIP 855
Cdd:cd15440    82 FSWMLLEGFQLYV------MLVEVfePEKSRIKWYYLFGYGLPALIVAVSAGVDPTGYGTEDHCWLSTENGFIWS-FVGP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  856 VLVFFVAAIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLrgakmdDDTADVYGYCF 935
Cdd:cd15440   155 VIVVLLANLVFLGMAIYVMCRHSSRSASKKDASKLKNIRGWLKGSIVLVVLLGLTWTFGLLFI------NQESIVMAYIF 228
                         250       260       270
                  ....*....|....*....|....*....|.
gi 221330065  936 ICFNTLLGLYIFVFHCIQNEKIRREYRKYVR 966
Cdd:cd15440   229 TILNSLQGLFIFIFHCVLNEKVRKELRRWLR 259
7tmB2_Latrophilin_Adhesion_I cd15252
Latrophilins and similar receptors, group I adhesion GPCRs, member of class B2 family of ...
698-966 1.10e-36

Latrophilins and similar receptors, group I adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; Group I adhesion GPCRs consist of latrophilins (also called lectomedins or latrotoxin receptors) and ETL (EGF-TM7-latrophilin-related protein. These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320380 [Multi-domain]  Cd Length: 257  Bit Score: 139.95  E-value: 1.10e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  698 MRIFIYISIGICVVFIVIALLTLKLFNGVfvKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSG 777
Cdd:cd15252     4 LTRITQVGIIISLVCLAICIFTFWFFRGL--QSDRTTIHKNLCISLFLAELVFLIGINTTTNKIFCSVIAGLLHYFFLAA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  778 TAWFCYEAFHSYStltsdeLLLEVDQTPK--VNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYaTFVIP 855
Cdd:cd15252    82 FAWMFIEGIQLYL------MLVEVFENEGsrHKNFYIFGYGSPAVIVGVSAALGYRYYGTTKVCWLSTENYFIW-SFIGP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  856 VLVFFVAAIGYTFLSWIIMCRKSrTGLKTkEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMdddtadVYGYCF 935
Cdd:cd15252   155 ATLIILLNLIFLGVAIYKMFRHT-AGLKP-EVSCLENIRSWARGAIALLFLLGLTWIFGVLHINHASV------VMAYLF 226
                         250       260       270
                  ....*....|....*....|....*....|.
gi 221330065  936 ICFNTLLGLYIFVFHCIQNEKIRREYRKYVR 966
Cdd:cd15252   227 TVSNSLQGMFIFLFHCVLSRKVRKEYYKLFR 257
7tmB2_Adhesion cd15040
adhesion receptors, subfamily B2 of the class B family of seven-transmembrane G ...
698-961 2.13e-32

adhesion receptors, subfamily B2 of the class B family of seven-transmembrane G protein-coupled receptors; The B2 subfamily of class B GPCRs consists of cell-adhesion receptors with 33 members in humans and vertebrates. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing a variety of structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, linked to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320168 [Multi-domain]  Cd Length: 253  Bit Score: 127.30  E-value: 2.13e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  698 MRIFIYISIGICVVFIVIALLTLklfngVFVKSARTSIYTSI--YLCLLAIELLF--LLGIEQTETSIFCGFITIFLHCA 773
Cdd:cd15040     4 LSIITYIGCGLSLLGLLLTIITY-----ILFRKLRKRKPTKIllNLCLALLLANLlfLFGINSTDNPVLCTAVAALLHYF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  774 ILSGTAWFCYEAFHSYSTLTSdelLLEVDQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQN-DYCVLMEANALFYAtF 852
Cdd:cd15040    79 LLASFMWMLVEALLLYLRLVK---VFGTYPRHFILKYALIGWGLPLIIVIITLAVDPDSYGNSsGYCWLSNGNGLYYA-F 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  853 VIPVLVFFVA-AIGYTFLSWIIMCRKSRTGLKTKEHTRLasvrfDIRCSFVFLLLLSAVWCSAYFYLRGAKMdddtadVY 931
Cdd:cd15040   155 LGPVLLIILVnLVIFVLVLRKLLRLSAKRNKKKRKKTKA-----QLRAAVSLFFLLGLTWIFGILAIFGARV------VF 223
                         250       260       270
                  ....*....|....*....|....*....|
gi 221330065  932 GYCFICFNTLLGLYIFVFHCIQNEKIRREY 961
Cdd:cd15040   224 QYLFAIFNSLQGFFIFIFHCLRNKEVRKAW 253
7tmB2_Latrophilin-2 cd16006
Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled ...
698-967 7.46e-27

Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320672 [Multi-domain]  Cd Length: 258  Bit Score: 111.55  E-value: 7.46e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  698 MRIFIYISIGICVVFIVIALLTLKLFNGVfvKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSG 777
Cdd:cd16006     4 LTVITWVGIVISLVCLAICIFTFCFFRGL--QSDRNTIHKNLCINLFIAEFIFLIGIDKTEYKIACPIFAGLLHFFFLAA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  778 TAWFCYEAFHSYStltsdeLLLEVDQT--PKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANAlFYATFVIP 855
Cdd:cd16006    82 FAWMCLEGVQLYL------MLVEVFESeySRKKYYYVAGYLFPATVVGVSAAIDYKSYGTEKACWLRVDNY-FIWSFIGP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  856 VLVFFVAAIGYTFLSWIIMCRKSRTgLKtKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLrgakmdDDTADVYGYCF 935
Cdd:cd16006   155 VTFIILLNLIFLVITLCKMVKHSNT-LK-PDSSRLENIKSWVLGAFALLCLLGLTWSFGLLFI------NEETIVMAYLF 226
                         250       260       270
                  ....*....|....*....|....*....|..
gi 221330065  936 ICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQ 967
Cdd:cd16006   227 TIFNAFQGMFIFIFHCALQKKVRKEYSKCFRH 258
7tmB2_EMR cd15439
epidermal growth factor-like module-containing mucin-like hormone receptors, member of the ...
703-967 8.59e-27

epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors; group II adhesion GPCRs, including the epidermal growth factor (EGF)-module-containing, mucin-like hormone receptor (EMR1-4) and the leukocyte cell-surface antigen CD97, are primarily expressed in cells of the immune system. All EGF-TM7 receptors, which belong to the B2 subfamily of adhesion GPCRs, are members of group II, except for ETL (EGF-TM7-latrophilin related protein), which is classified into group I. Members of the EGF-TM7 receptors are characterized by the presence of varying number of N-terminal EGF-like domains, which play critical roles in ligand recognition and cell adhesion, linked by a stalk region to a class B seven-transmembrane domain. In the case of EMR2, alternative splicing results in four isoforms possessing either two (EGF1,2), three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. EMR2 shares strong sequence homology with CD97, differing by only six amino acids. CD97 is widely expressed on lymphocytes, monocytes, macrophages, dendritic cells, granulocytes and smooth muscle cells as well as in a variety of human tumors including colorectal, gastric, esophageal pancreatic, and thyroid carcinoma. However, unlike CD97, EMR2 is not found in those of CD97-positive tumor cells and is not expressed on lymphocytes but instead on monocytes, macrophages and granulocytes. CD97 has three known ligands: CD55, decay-accelerating factor for regulation of complement system; chondroitin sulfate, a glycosaminoglycan found in the extracellular matrix; and the integrin alpha5beta1, which play a role in angiogenesis. Although EMR2 does not effectively interact with CD55, the fourth EGF-like domain of this receptor binds to chondroitin sulfate to mediate cell attachment.


Pssm-ID: 320555 [Multi-domain]  Cd Length: 263  Bit Score: 111.28  E-value: 8.59e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  703 YISIGICVVFIVIALLTLKLFNGVfvKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFC 782
Cdd:cd15439     9 YVGLIISLLCLFLAILTFLLCRSI--RNTSTSLHLQLSLCLFLADLLFLVGIDRTDNKVLCSIIAGFLHYLFLACFAWMF 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  783 YEAFHSYSTLTSdellLEV-----DQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVL-MEANalFYATFVIPV 856
Cdd:cd15439    87 LEAVHLFLTVRN----LKVvnyfsSHRFKKRFMYPVGYGLPAVIVAISAAVNPQGYGTPKHCWLsMEKG--FIWSFLGPV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  857 LVFFVaaIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAkmdddtADVYGYCFI 936
Cdd:cd15439   161 CVIIV--INLVLFCLTLWILREKLSSLNAEVSTLKNTRLLTFKAIAQLFILGCTWILGLFQVGPV------ATVMAYLFT 232
                         250       260       270
                  ....*....|....*....|....*....|.
gi 221330065  937 CFNTLLGLYIFVFHCIQNEKIRREYRKYVRQ 967
Cdd:cd15439   233 ITNSLQGVFIFLVHCLLNRQVREEYRRWITG 263
7tm_classB cd13952
class B family of seven-transmembrane G protein-coupled receptors; The class B of ...
698-961 1.97e-26

class B family of seven-transmembrane G protein-coupled receptors; The class B of seven-transmembrane GPCRs is classified into three major subfamilies: subfamily B1 (secretin-like receptor family), B2 (adhesion family), and B3 (Methuselah-like family). The class B receptors have been identified in all the vertebrates, from fishes to mammals, as well as invertebrates including Caenorhabditis elegans and Drosophila melanogaster, but are not present in plants, fungi or prokaryotes. The B1 subfamily comprises receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the subfamily B1 receptors preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. The subfamily B2 consists of cell-adhesion receptors with 33 members in humans and vertebrates. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing a variety of structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, linked to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Furthermore, the subfamily B3 includes Methuselah (Mth) protein, which was originally identified in Drosophila as a GPCR affecting stress resistance and aging, and its closely related proteins.


Pssm-ID: 410627 [Multi-domain]  Cd Length: 260  Bit Score: 110.38  E-value: 1.97e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  698 MRIFIYISIGICVVFIVIALLTLklfngVFVKSART-SIYTSIYLCLLAIELLFLLGIEQTETS----IFCGFITIFLHC 772
Cdd:cd13952     4 LSIITYIGCSLSLVGLLLTIITY-----LLFPKLRNlRGKILINLCLSLLLAQLLFLIGQLLTSsdrpVLCKALAILLHY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  773 AILSGTAWFCYEAFHSYSTLTSdelLLEVDQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQ-----NDYCVLMEANAL 847
Cdd:cd13952    79 FLLASFFWMLVEAFDLYRTFVK---VFGSSERRRFLKYSLYGWGLPLLIVIITAIVDFSLYGPspgygGEYCWLSNGNAL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  848 FYAtFVIPVLVFFVAAIgyTFLSWI--IMCRKSRtglKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYlrgakMDD 925
Cdd:cd13952   156 LWA-FYGPVLLILLVNL--VFFILTvrILLRKLR---ETPKQSERKSDRKQLRAYLKLFPLMGLTWIFGILA-----PFV 224
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 221330065  926 DTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREY 961
Cdd:cd13952   225 GGSLVFWYLFDILNSLQGFFIFLIFCLKNKEVRRLL 260
7tmB2_CELSR1 cd15991
Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of ...
698-962 7.58e-22

Cadherin EGF LAG seven-pass G-type receptor 1, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320657 [Multi-domain]  Cd Length: 254  Bit Score: 96.84  E-value: 7.58e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  698 MRIFIYISIGICVVFIVIALLTLKLFNGVfvKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSG 777
Cdd:cd15991     4 LKIITYTTVSLSLVALLITFILLVLIRTL--RSNLHSIHKNLVAALFFSELIFLIGINQTENPFVCTVVAILLHYFYMST 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  778 TAWFCYEAFHSYSTLTSdelLLEVDQTPkVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYaTFVIPVL 857
Cdd:cd15991    82 FAWMFVEGLHIYRMLTE---VRNINTGH-MRFYYVVGWGIPAIITGLAVGLDPQGYGNPDFCWLSVQDTLIW-SFAGPIG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  858 VFFVAAIGYTFLSWIIMCRKSRtglKTKEHTRLASVrfdIRCSFVFLLLLSAVWcsayfYLRGAKMDDDTADvYGYCFIC 937
Cdd:cd15991   157 IVVIINTVIFVLAAKASCGRRQ---RYFEKSGVISM---LRTAFLLLLLISATW-----LLGLMAVNSDTLS-FHYLFAI 224
                         250       260
                  ....*....|....*....|....*
gi 221330065  938 FNTLLGLYIFVFHCIQNEKIRREYR 962
Cdd:cd15991   225 FSCLQGIFIFFFHCIFNKEVRKHLK 249
Gal_Rha_Lectin_dCirl cd22830
galactose/rhamnose binding lectin domain found in Drosophila melanogaster Latrophilin Cirl and ...
1-45 5.68e-21

galactose/rhamnose binding lectin domain found in Drosophila melanogaster Latrophilin Cirl and similar proteins; Latrophilin Cirl (calcium-independent receptor for latrotoxin) is an adhesion-type G-protein-coupled receptor (aGPCR) that acts as a molecular sensor and signal transducer that detects and converts mechanical stimuli into a metabotropic response. It functions in mechanosensory neurons by modulating ionotropic receptor currents, the initiating step of cellular mechanosensation. The model corresponds to a galactose/rhamnose-binding lectin domain found at the N-terminus of Latrophilin Cirl.


Pssm-ID: 438687 [Multi-domain]  Cd Length: 92  Bit Score: 88.83  E-value: 5.68e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 221330065    1 MFPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQC 45
Cdd:cd22830    48 MSPRSLRVVQERCDGKRSCSIPASSSVFGDPCPGTPKYLEVHYQC 92
7tmB2_Latrophilin cd15436
Latrophilins, member of the class B2 family of seven-transmembrane G protein-coupled receptors; ...
700-966 7.61e-21

Latrophilins, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320552 [Multi-domain]  Cd Length: 258  Bit Score: 94.09  E-value: 7.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  700 IFIYISIGICVVFIVIALLTLKLFNGVfvKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTA 779
Cdd:cd15436     6 VITWVGIVISLVCLLICIFTFCFFRGL--QTDRNTIHKNLCINLFIAELLFLIGINRTQYTIACPIFAGLLHFFFLAAFC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  780 WFCYEAFHSYStltsdeLLLEV--DQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANaLFYATFVIPVL 857
Cdd:cd15436    84 WLCLEGVQLYL------LLVEVfeSEYSRRKYFYLCGYSFPALVVAVSAAIDYRSYGTEKACWLRVDN-YFIWSFIGPVT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  858 vfFVAAIGYTFLSwIIMCRK-SRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMdddtadVYGYCFI 936
Cdd:cd15436   157 --FVITLNLVFLV-ITLHKMvSHSDLLKPDSSRLDNIKSWALGAIALLFLLGLTWSFGLMFINEESV------VMAYLFT 227
                         250       260       270
                  ....*....|....*....|....*....|
gi 221330065  937 CFNTLLGLYIFVFHCIQNEKIRREYRKYVR 966
Cdd:cd15436   228 IFNAFQGVFIFIFHCALQKKVRKEYSKCLR 257
7tmB2_Latrophilin-1 cd16007
Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled ...
698-967 1.59e-20

Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320673 [Multi-domain]  Cd Length: 258  Bit Score: 93.06  E-value: 1.59e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  698 MRIFIYISIGICVVFIVIALLTLKLFNGVfvKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSG 777
Cdd:cd16007     4 LSVITWVGIVISLVCLAICISTFCFLRGL--QTDRNTIHKNLCINLFLAELLFLIGIDKTQYQIACPIFAGLLHFFFLAA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  778 TAWFCYEAFHSYStltsdeLLLEVDQT--PKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANaLFYATFVIP 855
Cdd:cd16007    82 FSWLCLEGVQLYL------MLVEVFESeySRKKYYYLCGYCFPALVVGISAAIDYRSYGTEKACWLRVDN-YFIWSFIGP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  856 VLVFFVAAIGYTFLSWIIMCRKSrTGLKtKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLrgakmdDDTADVYGYCF 935
Cdd:cd16007   155 VSFVIVVNLVFLMVTLHKMIRSS-SVLK-PDSSRLDNIKSWALGAITLLFLLGLTWAFGLLFI------NKESVVMAYLF 226
                         250       260       270
                  ....*....|....*....|....*....|..
gi 221330065  936 ICFNTLLGLYIFVFHCIQNEKIRREYRKYVRQ 967
Cdd:cd16007   227 TTFNAFQGMFIFIFHCALQKKVHKEYSKCLRH 258
7tmB2_GPR133-like_Adhesion_V cd15933
orphan GPR133 and related proteins, group V adhesion GPCRs, member of class B2 family of ...
698-958 2.57e-19

orphan GPR133 and related proteins, group V adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; group V adhesion GPCRs include orphan receptors GPR133, GPR144, and closely related proteins. The function of GPR144 has not yet been characterized, whereas GPR133 is highly expressed in the pituitary gland and is coupled to the G(s) protein, leading to activation of adenylate cyclase pathway. Moreover, genetic variations in the GPR133 have been reported to be associated with adult height and heart rate. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320599 [Multi-domain]  Cd Length: 252  Bit Score: 89.31  E-value: 2.57e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  698 MRIFIYISIGICVVFIVIALLTLKLFNgvFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSG 777
Cdd:cd15933     4 LSIISYIGCGISIACLALTLIIFLVLR--VLSSDRFQIHKNLCVALLLAQILLLAGEWAEGNKVACKVVAILLHFFFMAA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  778 TAWFCYEAFHSYSTLTSdelllEVDQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYAtFVIPVL 857
Cdd:cd15933    82 FSWMLVEGLHLYLMIVK-----VFNYKSKMRYYYFIGWGLPAIIVAISLAILFDDYGSPNVCWLSLDDGLIWA-FVGPVI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  858 vfFVAAIGYTFLSWI--IMCRKSRTGLKTKEHTrLASVRFDIRCSFVFLLLLSAVWcsayfyLRGAKMDDDTADVYGYCF 935
Cdd:cd15933   156 --FIITVNTVILILVvkITVSLSTNDAKKSQGT-LAQIKSTAKASVVLLPILGLTW------LFGVLVVNSQTIVFQYIF 226
                         250       260
                  ....*....|....*....|...
gi 221330065  936 ICFNTLLGLYIFVFHCIQNEKIR 958
Cdd:cd15933   227 VILNSLQGLMIFLFHCVLNSEVR 249
7tm_2 pfam00002
7 transmembrane receptor (Secretin family); This family is known as Family B, the ...
695-946 3.45e-19

7 transmembrane receptor (Secretin family); This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs). They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteriztic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.


Pssm-ID: 459625 [Multi-domain]  Cd Length: 248  Bit Score: 88.88  E-value: 3.45e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065   695 DGNMRIFIYISIGICVVFIVIALLTLKLFNGVfvKSARTSIYTSIYLCLLAIELLFLLGIEQTETS--------IFCGFI 766
Cdd:pfam00002    1 ALSLKVIYTVGYSLSLVALLLAIAIFLLFRKL--HCTRNYIHLNLFASFILRALLFLVGDAVLFNKqdldhcswVGCKVV 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065   767 TIFLHCAILSGTAWFCYEAFHSYStltsdeLLLEV--DQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEA 844
Cdd:pfam00002   79 AVFLHYFFLANFFWMLVEGLYLYT------LLVEVffSERKYFWWYLLIGWGVPALVVGIWAGVDPKGYGEDDGCWLSNE 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065   845 NALFYaTFVIPVLVFFVaaIGYTFLSWI--IMCRKSRTglKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRgak 922
Cdd:pfam00002  153 NGLWW-IIRGPILLIIL--VNFIIFINIvrILVQKLRE--TNMGKSDLKQYRRLAKSTLLLLPLLGITWVFGLFAFN--- 224
                          250       260
                   ....*....|....*....|....
gi 221330065   923 MDDDTADVYGYCFICFNTLLGLYI 946
Cdd:pfam00002  225 PENTLRVVFLYLFLILNSFQGFFV 248
7tmB2_EMR_Adhesion_II cd15931
EGF-like module receptors, group II adhesion GPCRs, member of class B2 family of ...
695-965 3.81e-19

EGF-like module receptors, group II adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; group II adhesion GPCRs, including the leukocyte cell-surface antigen CD97 and the epidermal growth factor (EGF)-module-containing, mucin-like hormone receptor (EMR1-4), are primarily expressed in cells of the immune system. All EGF-TM7 receptors, which belong to the B2 subfamily B2 of adhesion GPCRs, are members of group II, except for ETL (EGF-TM7-latrophilin related protein), which is classified into group I. Members of the EGF-TM7 receptors are characterized by the presence of varying numbers of N-terminal EGF-like domains, which play critical roles in ligand recognition and cell adhesion, linked by a stalk region to a class B seven-transmembrane domain. In the case of CD97, alternative splicing results in three isoforms possessing either three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. On the other hand, EMR2 generates four isoforms possessing either two (EGF1,2), three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. For example, CD97, which is involved in angiogenesis and the migration and invasion of tumor cells, has been shown to promote cell aggregation in a GPS proteolysis-dependent manner. CD97 is widely expressed on lymphocytes, monocytes, macrophages, dendritic cells, granulocytes and smooth muscle cells as well as in a variety of human tumors including colorectal, gastric, esophageal pancreatic, and thyroid carcinoma. EMR2 shares strong sequence homology with CD97, differing by only six amino acids. However, unlike CD97, EMR2 is not found in those of CD97-positive tumor cells and is not expressed on lymphocytes but instead on monocytes, macrophages and granulocytes. CD97 has three known ligands: CD55, decay-accelerating factor for regulation of complement system; chondroitin sulfate, a glycosaminoglycan found in the extracellular matrix; and the integrin alpha5beta1, which play a role in angiogenesis. Although EMR2 does not effectively interact with CD55, the fourth EGF-like domain of this receptor binds to chondroitin sulfate to mediate cell attachment.


Pssm-ID: 320597 [Multi-domain]  Cd Length: 262  Bit Score: 89.11  E-value: 3.81e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  695 DGNMRIFIYISIGICVVFIVIALLTLKLFNgvFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAI 774
Cdd:cd15931     1 DPFLEWINRVGVIVSLFCLGLAIFTFLLCR--WIPKINTTAHLHLCLCLSMSHTLFLAGIEYVENELACTVMAGLLHYLF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  775 LSGTAWFCYEAFhsystltsdELLLEVDQTPKVNCY----------YLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEA 844
Cdd:cd15931    79 LASFVWMLLEAL---------QLHLLVRRLTKVQVIqrdglprpllCLIGYGVPFLIVGVSALVYSDGYGEAKMCWLSQE 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  845 NALFYAtFVIPVLvfFVAAIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLrgakmd 924
Cdd:cd15931   150 RGFNWS-FLGPVI--AIIGINWILFCATLWCLRQTLSNMNSDISQLKDTRLLTFKAVAQLFILGCTWVLGLFQT------ 220
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 221330065  925 DDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYV 965
Cdd:cd15931   221 NPVALVFQYLFTILNSLQGAFLFLVHCLLNKEVREEYIKWL 261
GPS smart00303
G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin ...
637-684 6.60e-19

G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin REJ and polycystin.


Pssm-ID: 197639  Cd Length: 49  Bit Score: 81.66  E-value: 6.60e-19
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 221330065    637 TNPTCVFWNYIDHAWSANGCSLESTNRTHSVCSCNHLTNFAILMDVVD 684
Cdd:smart00303    1 FNPICVFWDESSGEWSTRGCELLETNGTHTTCSCNHLTTFAVLMDVPP 48
7tmB2_Latrophilin-3 cd16005
Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled ...
698-966 3.82e-18

Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Latrophilins (also called lectomedins or latrotoxin receptors) belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: LPH1 (latrophilin-1), LPH2, and LPH3. The latrophilin-1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. Latrophilin-2 and -3, although sharing strong sequence homology to latrophilin-1, do not bind alpha-latrotoxin. While latrophilin-3 is also brain specific, latrophilin-2 is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. ETL, a seven transmembrane receptor containing EGF-like repeats is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. The function of the ETL is unknown. All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320671 [Multi-domain]  Cd Length: 258  Bit Score: 86.15  E-value: 3.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  698 MRIFIYISIGICVVFIVIALLTLKLFNGVfvKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSG 777
Cdd:cd16005     4 LDVITWVGILLSLVCLLICIFTFCFFRGL--QSDRNTIHKNLCISLFVAELLFLIGINRTDQPIACAVFAALLHFFFLAA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  778 TAWFCYEAFHSYSTLTSdelLLEVDQTPKvNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLmEANALFYATFVIPVL 857
Cdd:cd16005    82 FTWMFLEGVQLYIMLVE---VFESEHSRR-KYFYLVGYGMPALIVAVSAAVDYRSYGTDKVCWL-RLDTYFIWSFIGPAT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  858 VFFVaaIGYTFLSWIIMCRKSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLrgakmdDDTADVYGYCFIC 937
Cdd:cd16005   157 LIIM--LNVIFLGIALYKMFHHTAILKPESGCLDNIKSWVIGAIALLCLLGLTWAFGLMYI------NESTVIMAYLFTI 228
                         250       260
                  ....*....|....*....|....*....
gi 221330065  938 FNTLLGLYIFVFHCIQNEKIRREYRKYVR 966
Cdd:cd16005   229 FNSLQGMFIFIFHCVLQKKVRKEYGKCLR 257
GPS pfam01825
GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for ...
639-679 1.79e-17

GPCR proteolysis site, GPS, motif; The GPS motif is found in GPCRs, and is the site for auto-proteolysis, so is thus named, GPS. The GPS motif is a conserved sequence of ~40 amino acids containing canonical cysteine and tryptophan residues, and is the most highly conserved part of the domain. In most, if not all, cell-adhesion GPCRs these undergo autoproteolysis in the GPS between a conserved aliphatic residue (usually a leucine) and a threonine, serine, or cysteine residue. In higher eukaryotes this motif is found embedded in the C-terminal beta-stranded part of a GAIN domain - GPCR-Autoproteolysis INducing (GAIN). The GAIN-GPS domain adopts a fold in which the GPS motif, at the C-terminus, forms five beta-strands that are tightly integrated into the overall GAIN domain. The GPS motif, evolutionarily conserved from tetrahymena to mammals, is the only extracellular domain shared by all human cell-adhesion GPCRs and PKD proteins, and is the locus of multiple human disease mutations. The GAIN-GPS domain is both necessary and sufficient functionally for autoproteolysis, suggesting an autoproteolytic mechanism whereby the overall GAIN domain fine-tunes the chemical environment in the GPS to catalyze peptide bond hydrolysis. In the cell-adhesion GPCRs and PKD proteins, the GPS motif is always located at the end of their long N-terminal extracellular regions, immediately before the first transmembrane helix of the respective protein.


Pssm-ID: 460350  Cd Length: 44  Bit Score: 77.35  E-value: 1.79e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 221330065   639 PTCVFWNYIDH---AWSANGCSLESTNRTHSVCSCNHLTNFAIL 679
Cdd:pfam01825    1 PQCVFWDFTNSttgRWSTEGCTTVSLNDTHTVCSCNHLTSFAVL 44
7tmB2_GPR133 cd15256
orphan adhesion receptor GPR133, member of the class B2 family of seven-transmembrane G ...
703-962 2.65e-17

orphan adhesion receptor GPR133, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR133 is an orphan receptor that belongs to the group V adhesion-GPCRs together with GPR144. The function of GPR144 has not yet been characterized, whereas GPR133 is highly expressed in the pituitary gland and is coupled to the Gs protein, leading to activation of adenylyl cyclase pathway. Moreover, genetic variations in the GPR133 have been reported to be associated with adult height and heart rate. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320384 [Multi-domain]  Cd Length: 260  Bit Score: 83.82  E-value: 2.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  703 YISIGICVVFIVIALLTLKLFNGV-FVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWF 781
Cdd:cd15256     9 YVGCSLSIFCLAITLVTFAVLSSVsTIRNQRYHIHANLSFAVLVAQILLLISFRFEPGTLPCKIMAILLHFFFLSAFAWM 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  782 CYEAFHSYStltsdeLLLEV--DQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYAtFVIPVLVF 859
Cdd:cd15256    89 LVEGLHLYS------MVIKVfgSEESKHFYYYGIGWGSPLLICIISLTSALDSYGESDNCWLSLENGAIWA-FVAPALFV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  860 FVAAIGYTFLSWIIMCRKSRTGLKTkeHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMdddtadVYGYCFICFN 939
Cdd:cd15256   162 IVVNIGILIAVTRVISRISADNYKV--HGDANAFKLTAKAVAVLLPILGSSWVFGVLAVNTHAL------VFQYMFAIFN 233
                         250       260
                  ....*....|....*....|...
gi 221330065  940 TLLGLYIFVFHCIQNEKIRREYR 962
Cdd:cd15256   234 SLQGFFIFLFHCLLNSEVRAAFK 256
7tmB2_CELSR3 cd15993
Cadherin EGF LAG seven-pass G-type receptor 3, member of the class B2 family of ...
700-975 3.94e-17

Cadherin EGF LAG seven-pass G-type receptor 3, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. Celsr3 is expressed in both the developing and adult mouse brain. It has been functionally implicated in proper neuronal migration and axon guidance in the CNS. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320659 [Multi-domain]  Cd Length: 254  Bit Score: 82.97  E-value: 3.94e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  700 IFIYISIGICVVFIVIALLTLKLFNGVfvKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTA 779
Cdd:cd15993     6 IVTYSSVSASLAALVLTFSVLTCLRGL--KSNTRGIHSNIAAALFLSELLFLLGINRTENQFLCTVVAILLHYFFLSTFA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  780 WFCYEAFHSYSTLTSDElllEVDQTPkVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYaTFVIPVLVF 859
Cdd:cd15993    84 WLFVQGLHIYRMQTEAR---NVNFGA-MRFYYAIGWGVPAIITGLAVGLDPEGYGNPDFCWISIHDKLVW-SFAGPIVVV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  860 FVAAIGYTFLSWIIMCRksrtglKTKEHTRLASVRFDIRCSFVFLLLLSAVWcsayfyLRGAKMDDDTADVYGYCFICFN 939
Cdd:cd15993   159 IVMNGVMFLLVARMSCS------PGQKETKKTSVLMTLRSSFLLLLLISATW------LFGLLAVNNSVLAFHYLHAILC 226
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 221330065  940 TLLGLYIFVFHCIQNEKIrreyrkyvrQHAWLPKCL 975
Cdd:cd15993   227 CLQGLAVLLLFCVLNEEV---------QEAWKLACL 253
7tmB2_GPR64 cd15444
orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B ...
762-965 2.16e-16

orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors; GPR64 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR56, GPR97, GPR112, GPR114, and GPR126. GPR64 is mainly expressed in the epididymis of male reproductive tract, and targeted deletion of GPR64 causes sperm stasis and efferent duct blockage due to abnormal fluid reabsorption, resulting in male infertility. GPR64 is also over-expressed in Ewing's sarcoma (ES), as well as upregulated in other carcinomas from kidney, prostate or lung, and promotes invasiveness and metastasis in ES via the upregulation of placental growth factor (PGF) and matrix metalloproteinase (MMP) 1. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320560 [Multi-domain]  Cd Length: 271  Bit Score: 81.03  E-value: 2.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  762 FCGFITIFLHCAILSGTAWFCYEAFHSYSTLTsdelllevdqtpKV-NCY---YLLSY-----GLSLSVVAISLVIDPST 832
Cdd:cd15444    70 LCISVAVFLHYFLLVSFTWMGLEAFHMYLALV------------KVfNTYirkYILKFcivgwGVPAVVVAIVLAVSKDN 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  833 Y-----------TQNDYCVLmEANALFYATFVIPVLVFFVAAIGYTFLSWIIMCR-KSRTGLKTKEHTRLAsvrfDIRCS 900
Cdd:cd15444   138 YglgsygkspngSTDDFCWI-NNNIVFYITVVGYFCVIFLLNISMFIVVLVQLCRiKKQKQLGAQRKTSLQ----DLRSV 212
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221330065  901 FVFLLLLSAVWCSAYFYLRGAKMdddtadVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYV 965
Cdd:cd15444   213 AGITFLLGITWGFAFFAWGPVNL------AFMYLFAIFNTLQGFFIFIFYCVAKENVRKQWRRYL 271
7tmB2_CD97 cd15438
CD97 antigen, member of the class B2 family of seven-transmembrane G protein-coupled receptors; ...
704-963 2.31e-16

CD97 antigen, member of the class B2 family of seven-transmembrane G protein-coupled receptors; group II adhesion GPCRs, including the leukocyte cell-surface antigen CD97 and the epidermal growth factor (EGF)-module-containing, mucin-like hormone receptor (EMR1-4), are primarily expressed in cells of the immune system. All EGF-TM7 receptors, which belong to the B2 subfamily B2 of adhesion GPCRs, are members of group II, except for ETL (EGF-TM7-latrophilin related protein), which is classified into group I. Members of the EGF-TM7 receptors are characterized by the presence of varying numbers of N-terminal EGF-like domains, which play critical roles in ligand recognition and cell adhesion, linked by a stalk region to a class B seven-transmembrane domain. In the case of CD97, alternative splicing results in three isoforms possessing either three (EGF1,2,5), four (EGF1,2,3,5) or five (EGF1,2,3,4,5) EGF-like domains. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. For example, CD97, which is involved in angiogenesis and the migration and invasion of tumor cells, has been shown to promote cell aggregation in a GPS proteolysis-dependent manner. CD97 is widely expressed on lymphocytes, monocytes, macrophages, dendritic cells, granulocytes and smooth muscle cells as well as in a variety of human tumors including colorectal, gastric, esophageal pancreatic, and thyroid carcinoma. EMR2 shares strong sequence homology with CD97, differing by only six amino acids. However, unlike CD97, EMR2 is not found in those of CD97-positive tumor cells and is not expressed on lymphocytes but instead on monocytes, macrophages and granulocytes. CD97 has three known ligands: CD55, decay-accelerating factor for regulation of complement system; chondroitin sulfate, a glycosaminoglycan found in the extracellular matrix; and the integrin alpha5beta1, which play a role in angiogenesis. Although EMR2 does not effectively interact with CD55, the fourth EGF-like domain of this receptor binds to chondroitin sulfate to mediate cell attachment.


Pssm-ID: 320554 [Multi-domain]  Cd Length: 261  Bit Score: 80.96  E-value: 2.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  704 ISIGICVVFIVIALLTLKLFNGVfvKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCY 783
Cdd:cd15438    10 VGLSVSLFCLFLCILTFLFCRSI--RGTRNTIHLHLCLSLFLAHLIFLLGINNTNNQVACAVVAGLLHYFFLAAFCWMSL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  784 EAFHSYStltsdeLLLEVDQTPKVNCYYLL--SYGLSLSVVAISLVIDPSTYTQNDYCVLMEANAlFYATFVIPV-LVFF 860
Cdd:cd15438    88 EGVELYL------MVVQVFNTQSLKKRYLLliGYGVPLVIVAISAAVNSKGYGTQRHCWLSLERG-FLWSFLGPVcLIIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  861 VAAIGYTFLSWIIMCRKSRTGLKTKEHTRLASvrFDIrCSFVFLLLLSAVWCSAYFYLrgakmdDDTADVYGYCFICFNT 940
Cdd:cd15438   161 VNAIIFVITVWKLAEKFSSINPDMEKLRKIRA--LTI-TAIAQLCILGCTWIFGFFQF------SDSTLVMSYLFTILNS 231
                         250       260
                  ....*....|....*....|...
gi 221330065  941 LLGLYIFVFHCIQNEKIRREYRK 963
Cdd:cd15438   232 LQGLFIFLLHCLLSKQVREEYSR 254
7tmB2_ETL cd15437
Epidermal Growth Factor, latrophilin and seven transmembrane domain-containing protein 1; ...
713-961 1.48e-14

Epidermal Growth Factor, latrophilin and seven transmembrane domain-containing protein 1; member of the class B2 family of seven-transmembrane G protein-coupled receptors; ETL (EGF-TM7-latrophilin-related protein) belongs to Group I adhesion GPCRs, which also include latrophilins (also called lectomedins or latrotoxin receptors). All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. ETL, for instance, contains EGF-like repeats, which also present in other EGF-TM7 adhesion GPCRs, such as Cadherin EGF LAG seven-pass G-type receptors (CELSR1-3), EGF-like module receptors (EMR1-3), CD97, and Flamingo. ETL is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320553 [Multi-domain]  Cd Length: 258  Bit Score: 75.68  E-value: 1.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  713 IVIALLTLKL--FNGVF---VKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFH 787
Cdd:cd15437    12 IIISLICLSMciFTFWFfseIQSTRTTIHKNLCCSLFLAELIFLIGINMNANKLFCSIIAGLLHYFFLAAFAWMCIEGIH 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  788 SYSTLTS---DELLLEVDqtpkvncYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIPVLVFFVAAI 864
Cdd:cd15437    92 LYLIVVGviyNKGFLHKN-------FYIFGYGSPAVVVGISAALGYKYYGTTKVCWLSTENNFIWSFIGPACLIILVNLL 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  865 GYTFLSWIIMcrkSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMdddtadVYGYCFICFNTLLGL 944
Cdd:cd15437   165 AFGVIIYKVF---RHTAMLKPEVSCYENIRSCARGALALLFLLGATWIFGVLHVVYGSV------VTAYLFTISNAFQGM 235
                         250
                  ....*....|....*..
gi 221330065  945 YIFVFHCIQNEKIRREY 961
Cdd:cd15437   236 FIFIFLCVLSRKIQEEY 252
Gal_Rha_Lectin_SUL-I-like cd22827
galactose/rhamnose binding lectin domain found in Toxopneustes pileolus rhamnose-binding ...
3-45 1.65e-14

galactose/rhamnose binding lectin domain found in Toxopneustes pileolus rhamnose-binding lectin SUL-I and similar proteins; SUL-I is a galactose/rhamnose-binding lectin with mitogenic, chemotactic, and cytotoxic activity. These activities can be triggered by binding of the lectin to specific carbohydrate chains on target cells. SUL-I may be involved in self-defense against invading microorganisms. SUL-I is composed of three distinctive domains with a folding structure similar to galactose/rhamnose-binding lectin domain found in proteins such as mammalian latrophilins, Oncorhynchus keta L-rhamnose-binding lectins (CSLs), and Silurus asotus rhamnose-binding lectin (SAL). The family also includes Heliocidaris crassispina D-galactoside-specific lectin, also known as sea urchin egg lectin or SUEL, and Echinometra lucunter L-rhamnose-binding lectin ELEL-1, both of which contain only one galactose/rhamnose-binding lectin domain. SUEL binds D-galactoside. It may play an important role in the activation of eggs triggered by fertilization, or in their subsequent differentiation. The dimeric form is essential for hemagglutination activity of SUEL. ELEL-1 is a rhamnose-binding lectin that also binds alpha-D-melibiose, alpha-D-lactose, beta-D-lactose, methyl-alpha-D-galactopyranoside, methyl-beta-D--galactopyranoside and D-galactose, but not D-arabinose, L-fucose, D-glucose, D-mannose, D-maltose, D-sucrose, N-acetyl-D-galactosamine, N-acetyl-D-glucosamine, N-acetyl-D-mannosamine-D-xylose, or by glycoproteins orosomucoid, thyroglobulin, ovomucoid and porcine stomach mucin. It shows cation-independent hemagglutinating activity against rabbit and human erythrocytes. ELEL-1 agglutinates cells of Gram-positive bacterial species S. aureus but not those of Gram-negative E. coli.


Pssm-ID: 438684 [Multi-domain]  Cd Length: 89  Bit Score: 70.31  E-value: 1.65e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 221330065    3 PKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQC 45
Cdd:cd22827    47 SNSLSIVRNRCNGKRSCSVKASNSVFGDPCVGTYKYLEVRYRC 89
7tmB2_GPR124-like_Adhesion_III cd15259
orphan GPR124 and related proteins, group III adhesion GPCRs, member of class B2 family of ...
698-962 2.66e-14

orphan GPR124 and related proteins, group III adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors; group III adhesion GPCRs include orphan GPR123, GPR124, GPR125, and their closely related proteins. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. GPR123 is predominantly expressed in the CNS including thalamus, brain stem and regions containing large pyramidal cells. GPR124, also known as tumor endothelial marker 5 (TEM5), is highly expressed in tumor vessels and in the vasculature of the developing embryo. GPR124 is essentially required for proper angiogenic sprouting into neural tissue, CNS-specific vascularization, and formation of the blood-brain barrier. GPR124 also interacts with the PDZ domain of DLG1 (discs large homolog 1) through its PDZ-binding motif. Recently, studies of double-knockout mice showed that GPR124 functions as a co-activator of Wnt7a/Wnt7b-dependent beta-catenin signaling in brain endothelium. Furthermore, WNT7-stimulated beta-catenin signaling is regulated by GPR124's intracellular PDZ binding motif and leucine-rich repeats (LRR) in its N-terminal extracellular domain. GPR125 directly interacts with dishevelled (Dvl) via its intracellular C-terminus, and together, GPR125 and Dvl recruit a subset of planar cell polarity (PCP) components into membrane subdomains, a prerequisite for activation of Wnt/PCP signaling. Thus, GPR125 influences the noncanonical WNT/PCP pathway, which does not involve beta-catenin, through interacting with and modulating the distribution of Dvl.


Pssm-ID: 320387 [Multi-domain]  Cd Length: 260  Bit Score: 74.72  E-value: 2.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  698 MRIFIYISIGICVVFIVIALLTLKLFnGVFVKSARTSIYTSIYLCLLAIELLF--LLGIEQTETSIFCGFITIFLHCAIL 775
Cdd:cd15259     4 LHPVVYAGAALCLLCLLATIITYIVF-HRLIRISRKGRHMLVNLCLHLLLTCVvfVGGINRTANQLVCQAVGILLHYSTL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  776 SGTAWFCYEAFHSYSTLTSDELL-LEVDQTPKVNC----YYLLSYGLSLSVVAISLVIDPSTYTQNDYCvLMEANALFYA 850
Cdd:cd15259    83 CTLLWVGVTARNMYKQVTKTAKPpQDEDQPPRPPKpmlrFYLIGWGIPLIICGITAAVNLDNYSTYDYC-WLAWDPSLGA 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  851 tFVIPVlVFFVAAIGYTFLswiimcrksRTGLKTKEHTrlASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDdtaDV 930
Cdd:cd15259   162 -FYGPA-ALIVLVNCIYFL---------RIYCQLKGAP--VSFQSQLRGAVITLFLYVAMWACGALAVSQRYFLD---LV 225
                         250       260       270
                  ....*....|....*....|....*....|..
gi 221330065  931 YGYCFICFNTLLGLYIFVFHCIQNEKIRREYR 962
Cdd:cd15259   226 FSCLYGATCSSLGLFVLIHHCLSREDVRQSWR 257
7tmB2_GPR112 cd15997
Probable G protein-coupled receptor 112, member of the class B2 family of seven-transmembrane ...
763-962 2.41e-13

Probable G protein-coupled receptor 112, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR112 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR56, GPR64, GPR97, GPR114, and GPR126. GPR112 is specifically expressed in normal enterochromatin cells and gastrointestinal neuroendocrine carcinoma cells, but its biological function is unknown. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320663  Cd Length: 269  Bit Score: 72.00  E-value: 2.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  763 CGFITIFLHCAILSGTAWFCYEAFHSYSTLTsdelllevdqtpKV-NCY---YLLSY-----GLSLSVVAISLVIDPSTY 833
Cdd:cd15997    70 CITVAAFLHYFLLASFTWMGLEAVHMYFALV------------KVfNIYipnYILKFciagwGIPAVVVALVLAINKDFY 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  834 ----------TQNDYCvLMEANALFYATFVIPVLVFFVAAIgYTFLSWIIMCRKsrtgLKTKEHTRLASVRF--DIRCSF 901
Cdd:cd15997   138 gnelssdslhPSTPFC-WIQDDVVFYISVVAYFCLIFLCNI-SMFITVLIQIRS----MKAKKPSRNWKQGFlhDLKSVA 211
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221330065  902 VFLLLLSAVWCSAYFYLRGAKMdddtadVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYR 962
Cdd:cd15997   212 SLTFLLGLTWGFAFFAWGPVRI------FFLYLFSICNTLQGFFIFVFHCLMKENVRKQWR 266
Gal_Rha_Lectin_LPHNs cd22826
galactose/rhamnose binding lectin domain found in latrophilins; Latrophilins, also called ...
2-45 8.08e-13

galactose/rhamnose binding lectin domain found in latrophilins; Latrophilins, also called lectomedins or latrotoxin receptors, belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: latrophilin-1 (LPHN1), Latrophilin-2 (LPHN2), and Latrophilin-3 (LPHN3). The LPHN1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. LPHN2 and LPHN3, although sharing strong sequence homology to LPHN1, do not bind alpha-latrotoxin. While LPHN3 is also brain specific, LPHN2, is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. All members in this family contain a galactose/rhamnose-binding lectin domain at N-terminus.


Pssm-ID: 438683 [Multi-domain]  Cd Length: 92  Bit Score: 65.80  E-value: 8.08e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 221330065    2 FPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQC 45
Cdd:cd22826    49 LPDALAIVSQRCNNRTRCNVRADSSFFPDPCPGTFKYLEVIYEC 92
7tmB2_CELSR2 cd15992
Cadherin EGF LAG seven-pass G-type receptor 2, member of the class B2 family of ...
698-962 8.49e-13

Cadherin EGF LAG seven-pass G-type receptor 2, member of the class B2 family of seven-transmembrane G protein-coupled receptors; The group IV adhesion GPCRs include the cadherin EGF LAG seven-pass G-type receptors (CELSRs) and their Drosophila homolog Flamingo (also known as Starry night). These receptors are also classified as that belongs to the EGF-TM7 group of subfamily B2 adhesion GPCRs, because they contain EGF-like domains. Functionally, the group IV receptors act as key regulators of many physiological processes such as endocrine cell differentiation, neuronal migration, dendrite growth, axon, guidance, lymphatic vessel and valve formation, and planar cell polarity (PCP) during embryonic development. Three mammalian orthologs of Flamingo, Celsr1-3, are widely expressed in the nervous system from embryonic development until the adult stage. Each Celsr exhibits different expression patterns in the developing brain, suggesting that they serve distinct functions. Mutations of CELSR1 cause neural tube defects in the nervous system, while mutations of CELSR2 are associated with coronary heart disease. Moreover, CELSR1 and several other PCP signaling molecules, such as dishevelled, prickle, frizzled, have been shown to be upregulated in B lymphocytes of chronic lymphocytic leukemia patients. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. In the case of CELSR/Flamingo/Starry night, their extracellular domains comprise nine cadherin repeats linked to a series of epidermal growth factor (EGF)-like and laminin globular (G)-like domains. The cadherin repeats contain sequence motifs that mediate calcium-dependent cell-cell adhesion by homophilic interactions. Moreover, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320658  Cd Length: 255  Bit Score: 70.23  E-value: 8.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  698 MRIFIYISIGICVVFIVIALLTLKLFNGVfvKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSG 777
Cdd:cd15992     4 LKTLTWSSVGVTLGFLLLTFLFLLCLRAL--RSNKTSIRKNGATALFLSELVFILGINQADNPFACTVIAILLHFFYLCT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  778 TAWFCYEAFHSYSTLTSdelLLEVDQTPkVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYaTFVIPVL 857
Cdd:cd15992    82 FSWLFLEGLHIYRMLSE---VRDINYGP-MRFYYLIGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLIW-SFAGPVA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  858 VFFVAAIGYTFLSWIIMCRKSRTGLKTKEHTRLAsvrfdIRCSFVFLLLLSAVWCSAYFylrgaKMDDDTAdVYGYCFIC 937
Cdd:cd15992   157 FAVSMNVFLYILSSRASCSAQQQSFEKKKGPVSG-----LRTAFTVLLLVSVTCLLALL-----SVNSDVI-LFHYLFAG 225
                         250       260
                  ....*....|....*....|....*
gi 221330065  938 FNTLLGLYIFVFHCIQNEKIRREYR 962
Cdd:cd15992   226 FNCLQGPFIFLSHVVLLKEVRKALK 250
Gal_Lectin pfam02140
Galactose binding lectin domain;
2-45 9.77e-13

Galactose binding lectin domain;


Pssm-ID: 460460 [Multi-domain]  Cd Length: 79  Bit Score: 65.00  E-value: 9.77e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 221330065     2 FPKSLSVLNSRCAHKQSCGVLAATSMFG-DPCPGTHKYLEAHYQC 45
Cdd:pfam02140   35 SPNSLAIVSKACQGKNSCSVPASNSVFGgDPCPGTYKYLEVEYKC 79
7tmB3_Methuselah-like cd15039
Methuselah-like subfamily B3, member of the class B family of seven-transmembrane G ...
759-963 1.33e-12

Methuselah-like subfamily B3, member of the class B family of seven-transmembrane G protein-coupled receptors; The subfamily B3 of class B GPCRs consists of Methuselah (Mth) and its closely related proteins found in bilateria. Mth was originally identified in Drosophila as a GPCR affecting stress resistance and aging. In addition to the seven transmembrane helices, Mth contains an N-terminal extracellular domain involved in ligand binding, and a third intracellular loop (IC3) required for the specificity of G-protein coupling. Drosophila Mth mutants showed an increase in average lifespan by 35% and greater resistance to a variety of stress factors, including starvation, high temperature, and paraquat-induced oxidative toxicity. Moreover, mutations in two endogenous peptide ligands of Methuselah, Stunted A and B, showed an increased in lifespan and resistance to oxidative stress induced by dietary paraquat. These results strongly suggest that the Stunted-Methuselah system plays important roles in stress response and aging.


Pssm-ID: 410632 [Multi-domain]  Cd Length: 270  Bit Score: 69.95  E-value: 1.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  759 TSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPKVNCYYLL-SYGLSLSVVAISLVID---PSTYT 834
Cdd:cd15039    64 DSTLCVALGILLHFFFLAAFFWLNVMSFDIWRTFRGKRSSSSRSKERKRFLRYSLyAWGVPLLLVAVTIIVDfspNTDSL 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  835 Q----NDYCVLMEANALFYaTFVIPVLVFFVAAIG-YTFLSWIIMCRKSRTglkTKEHTRLASVRFDIRCSFVFLLLLSA 909
Cdd:cd15039   144 RpgygEGSCWISNPWALLL-YFYGPVALLLLFNIIlFILTAIRIRKVKKET---AKVQSRLRSDKQRFRLYLKLFVIMGV 219
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 221330065  910 VWCS---AYFYlrgakmddDTADVYGYCFICFNTLLGLYIFV-FHCiqNEKIRREYRK 963
Cdd:cd15039   220 TWILeiiSWFV--------GGSSVLWYIFDILNGLQGVFIFLiFVC--KRRVLRLLKK 267
7tmB2_GPR144 cd15255
orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G ...
709-963 3.66e-12

orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR144 is an orphan receptor that belongs to the group V adhesion-GPCRs together with GPR133. The function of GPR144 has not yet been characterized, whereas GPR133 is highly expressed in the pituitary gland and is coupled to the Gs protein, leading to activation of adenylyl cyclase pathway. Moreover, genetic variations in the GPR133 have been reported to be associated with adult height and heart rate. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320383 [Multi-domain]  Cd Length: 263  Bit Score: 68.34  E-value: 3.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  709 CVVFIVIALLTLKLFNGVFV-KSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFH 787
Cdd:cd15255    12 CGVSLCALIVTFILFLAVGVpKSERTTVHKNLIFALAAAEFLLMFSEWAKGNQVACWAVTALLHLFFLAAFSWMLVEGLL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  788 SYSTLTSdellLEVDQTPKVNCYYLLSYGLSLSVVAISLVIDPSTYTQNDYCVLMEANALFYAtFVIPVLvfFVAAIGYT 867
Cdd:cd15255    92 LWSKVVA----VNMSEDRRMKFYYVTGWGLPVVIVAVTLATSFNKYVADQHCWLNVQTDIIWA-FVGPVL--FVLTVNTF 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  868 FLSWIIMCRKSRTGLKTKEHTRLASVRFDI--------RCSFVFLLLLSAVW-CSAYFYLrgakmdddtADVYGYCFICF 938
Cdd:cd15255   165 VLFRVVMVTVSSARRRAKMLTPSSDLEKQIgiqiwataKPVLVLLPVLGLTWlCGVLVHL---------SDVWAYVFITL 235
                         250       260
                  ....*....|....*....|....*
gi 221330065  939 NTLLGLYIFVFHCIQNEKIRREYRK 963
Cdd:cd15255   236 NSFQGLYIFLVYAIYNSEVRNAIQR 260
Gal_Rha_Lectin cd22823
Galactose/rhamnose-binding lectin domain; Galactose/rhamnose-binding lectin domain is formed ...
2-45 5.24e-12

Galactose/rhamnose-binding lectin domain; Galactose/rhamnose-binding lectin domain is formed from a four-stranded antiparallel beta-sheet which packs against an alpha-helix. It was originally described as galactose-binding lectin domain since it was found in a galactose-binding sea urchin egg lectin (SUEL). SUEL was first isolated as a D-galactoside binding lectin, it was later shown that it binds to L-rhamnose preferentially. Galactose/rhamnose-binding lectin domain is also found in many rhamnose-binding lectins, such as Oncorhynchus keta L-rhamnose-binding lectins (CSLs) and Silurus asotus rhamnose-binding lectin (SAL). In addition, the superfamily includes many SUEL/CSLs/SAL homologous proteins, such as plant beta-galactosidases, mammalian latrophilins, Caenorhabditis elegans protein EVA-1 and its homolog, human protein EVA-1 homolog C (also known as C21orf63). Due to the lack of galactose/rhamnose-binding key residues, some superfamily members may not form a binding pocket for galactose/rhamnose. Therefore, they are unlikely to act as galactose/rhamnose-binding lectins.


Pssm-ID: 438682 [Multi-domain]  Cd Length: 91  Bit Score: 63.29  E-value: 5.24e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 221330065    2 FPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQC 45
Cdd:cd22823    48 SPDVLDIVKELCDGKQSCSVPASNSVFGDPCPGTSKYLEVTYTC 91
7tmB2_BAI_Adhesion_VII cd15251
brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 ...
709-966 7.92e-12

brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediate direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320379  Cd Length: 253  Bit Score: 67.28  E-value: 7.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  709 CVVFIVIALLTLKLFNgvFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHS 788
Cdd:cd15251    16 CLALLTLLAIYAAFWR--YIRSERSIILINFCLSIISSNILILVGQTQTLNKGVCTMTAAFLHFFFLSSFCWVLTEAWQS 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  789 YSTLTSDElllevdQTPKVNCYYL-LSYGLSLSVVAISLVIDPST-YTQNDYCVLMEANALFYAtFVIP--VLVFFVAAI 864
Cdd:cd15251    94 YMAVTGRM------RTRLIRKRFLcLGWGLPALVVAVSVGFTRTKgYGTSSYCWLSLEGGLLYA-FVGPaaAVVLVNMVI 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  865 GYTFLSWIImcrkSRTGLKTKEHTRLASvrfdircSFVFLLLLSAVWCSAYFylrgaKMDDDTADVYGYCFICFNTLLGL 944
Cdd:cd15251   167 GILVFNKLV----SRDGISDNAMASLWS-------SCVVLPLLALTWMSAVL-----AMTDRRSVLFQILFAVFDSLQGF 230
                         250       260
                  ....*....|....*....|..
gi 221330065  945 YIFVFHCIqnekIRREYRKYVR 966
Cdd:cd15251   231 VIVMVHCI----LRREVQDAVK 248
Gal_Rha_Lectin_EVA1_EVA1C_rpt1 cd22828
first galactose/rhamnose binding lectin domain found in Caenorhabditis elegans protein EVA-1, ...
3-45 5.82e-11

first galactose/rhamnose binding lectin domain found in Caenorhabditis elegans protein EVA-1, human protein EVA-1 homolog C and similar proteins; The family includes Caenorhabditis elegans protein EVA-1 and its homologs, such as human protein EVA-1 homolog C (also known as C21orf63). EVA-1 functions as an UNC-40 coreceptor to enhance attraction to the MADD-4 guidance cue in C. elegans. It also acts as a receptor for slt-1 and is required for the guidance of the AVM pioneer axon to the ventral nerve cord. Human C21orf63 is a type-1 transmembrane heparin-binding protein. Both human C21orf63 is a type-1 transmembrane heparin-binding protein. Members in this family contain two tandem galactose/rhamnose-binding lectin domains. This model corresponds to the first one.


Pssm-ID: 438685 [Multi-domain]  Cd Length: 105  Bit Score: 60.76  E-value: 5.82e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 221330065    3 PKSLSVLNSRCAHKQSCGVLAATSMFG-DPCPGTHKYLEAHYQC 45
Cdd:cd22828    60 PTALQKVVEECQKKRSCRLLVSSRTFGlDPCPGTSKYLEVAYKC 103
Gal_Rha_Lectin_SML_rpt2 cd22835
second galactose/rhamnose binding lectin domain found in Scomberomorus niphonius ...
12-45 1.83e-10

second galactose/rhamnose binding lectin domain found in Scomberomorus niphonius L-rhamnose-binding lectin (SML) and similar proteins; SML is a rhamnose-binding lectin that also binds melibiose, raffinose, D-galactose, L-arabinose, D-fucose, maltose and D-glucose with decreasing affinity. It does not bind D-arabinose, L-fucose, lactose, xylose or 2-deoxy-D-galactose. SML shows strong hemagglutinating activity against rabbit erythrocytes. SML contains two tandem galactose/rhamnose-binding lectin domains. This model corresponds to the second one.


Pssm-ID: 438692 [Multi-domain]  Cd Length: 92  Bit Score: 58.85  E-value: 1.83e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 221330065   12 RCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQC 45
Cdd:cd22835    59 RCNGKNSCSIKASNSVFGDPCVGTYKYLEVAYTC 92
7tmB2_GPR126 cd15996
orphan adhesion receptor GPR126, member of the class B2 family of seven-transmembrane G ...
762-965 6.08e-10

orphan adhesion receptor GPR126, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR126 is an orphan receptor that has been classified as that belongs to the Group VIII of adhesion GPCRs. Other members of the Group VII include orphan GPCRs such as GPR56, GPR64, GPR97, GPR112, and GPR114. GPR126 is required in Schwann cells for proper differentiation and myelination via G-Protein Activation. GPR126 is believed to couple to G(s)-protein, which leads to activation of adenylate cyclase for cAMP production. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320662  Cd Length: 271  Bit Score: 61.83  E-value: 6.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  762 FCGFITIFLHCAILSGTAWFCYEAFHSYSTLTsdelllevdqtpKV-NCY---YLLSY-----GLSLSVVAISLVIDPST 832
Cdd:cd15996    69 LCITVAVLLHFFLLATFTWMGLEAIHMYIALV------------KVfNTYirrYILKFciigwGLPALIVSIVLASTNDN 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  833 YTQN------------DYCvLMEANALFYATFVIPVLVFFVAAIGYTFLSWIIMCrkSRTGLKTKEHTRLASVRfDIRCS 900
Cdd:cd15996   137 YGYGyygkdkdgqggdEFC-WIKNPVVFYVTCAAYFGIMFLMNVAMFIVVMVQIC--GRNGKRSNRTLREEILR-NLRSV 212
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221330065  901 FVFLLLLSAVWCSAYFYLRGAKMdddtadVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYV 965
Cdd:cd15996   213 VSLTFLLGMTWGFAFFAWGPVNL------AFMYLFTIFNSLQGLFIFVFHCALKENVQKQWRRHL 271
Gal_Rha_Lectin_LPHN3 cd22846
galactose/rhamnose binding lectin domain found in latrophilin-3 and similar proteins; ...
2-46 6.89e-10

galactose/rhamnose binding lectin domain found in latrophilin-3 and similar proteins; Latrophilin-3 (LPHN3), also called adhesion G protein-coupled receptor L3 (ADGRL3), or calcium-independent alpha-latrotoxin receptor 3 (CIRL-3), or lectomedin-3, is a brain-specific calcium-independent receptor that plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. It is involved in the development of glutamatergic synapses in the cortex. This model corresponds to a galactose/rhamnose-binding lectin domain found at the N-terminus of LPHN3.


Pssm-ID: 438703 [Multi-domain]  Cd Length: 99  Bit Score: 57.80  E-value: 6.89e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 221330065    2 FPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQCI 46
Cdd:cd22846    52 LPDAYKIMSQRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQYECV 96
Gal_Rha_Lectin_RBL_rpt3 cd22837
third galactose/rhamnose binding lectin domain found in Silurus asotus rhamnose-binding lectin ...
5-45 8.46e-10

third galactose/rhamnose binding lectin domain found in Silurus asotus rhamnose-binding lectin (RBL) and similar proteins; RBL, also known as Silurus asotus (catfish) roe lectin (SAL), is a lectin that binds L-rhamnose. It also binds monosaccharides possessing steric similarity to the hydroxyl group orientation at C2 and C4 of the pyranose ring structure of L-rhamnose, such as L-mannose and L-lyxose. RBL does not require a Ca2+ ion or free thiol group for its agglutination activity. RBL contains three galactose/rhamnose-binding lectin domains. This model corresponds to the third one.


Pssm-ID: 438694 [Multi-domain]  Cd Length: 87  Bit Score: 57.05  E-value: 8.46e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 221330065    5 SLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQC 45
Cdd:cd22837    47 TLAYIRALCQGKQTCTLQASNSVFGDPCPGTYKYLRITYSC 87
Gal_Rha_Lectin_REJ3 cd22841
galactose/rhamnose binding lectin domain found in Strongylocentrotus purpuratus receptor for ...
8-45 1.21e-09

galactose/rhamnose binding lectin domain found in Strongylocentrotus purpuratus receptor for egg jelly 3 protein (REJ3) and similar proteins; REJ3 is a polycystin-1 protein (components of non-selective cation channels) that is cleaved at the GPS (G-protein-coupled receptor proteolytic site) domain and localizes to the acrosomal region of sea urchin sperm. REJ3 is a multidomain protein containing only one galactose/rhamnose-binding lectin domain at its N-terminus.


Pssm-ID: 438698 [Multi-domain]  Cd Length: 92  Bit Score: 56.71  E-value: 1.21e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 221330065    8 VLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQC 45
Cdd:cd22841    55 ILSACCNGQSQCTVTATNSIFGDPCPGTYKYLNVTYTC 92
Gal_Rha_Lectin_RBL_rpt2 cd22836
second galactose/rhamnose binding lectin domain found in Silurus asotus rhamnose-binding ...
2-45 1.69e-09

second galactose/rhamnose binding lectin domain found in Silurus asotus rhamnose-binding lectin (RBL) and similar proteins; RBL, also known as Silurus asotus (catfish) roe lectin (SAL), is a lectin that binds L-rhamnose. It also binds monosaccharides possessing steric similarity to the hydroxyl group orientation at C2 and C4 of the pyranose ring structure of L-rhamnose, such as L-mannose and L-lyxose. RBL does not require a Ca2+ ion or free thiol group for its agglutination activity. RBL contains three galactose/rhamnose-binding lectin domains. This model corresponds to the second one.


Pssm-ID: 438693 [Multi-domain]  Cd Length: 95  Bit Score: 56.53  E-value: 1.69e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 221330065    2 FPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQC 45
Cdd:cd22836    52 ASNSLAIVSQSCNGKKSCTVSASNSVFSDPCVGTYKYLYVTYSC 95
Gal_Rha_Lectin_LPHN1 cd22844
galactose/rhamnose binding lectin domain found in latrophilin-1 and similar proteins; ...
2-46 2.28e-09

galactose/rhamnose binding lectin domain found in latrophilin-1 and similar proteins; Latrophilin-1 (LPHN1), also called adhesion G protein-coupled receptor L1 (ADGRL1), or calcium-independent alpha-latrotoxin receptor 1 (CIRL-1), or lectomedin-2, is a brain-specific calcium-independent receptor that mediates the effect of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. This model corresponds to a galactose/rhamnose-binding lectin domain found at the N-terminus of LPHN1.


Pssm-ID: 438701 [Multi-domain]  Cd Length: 97  Bit Score: 56.21  E-value: 2.28e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 221330065    2 FPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQCI 46
Cdd:cd22844    51 LPDAFKIMSQRCNNRTQCVVVAGSDAFPDPCPGTYKYLEVQYDCV 95
7tmB2_GPR126-like_Adhesion_VIII cd15258
orphan GPR126 and related proteins, group VIII adhesion GPCRs, member of the class B2 family ...
763-962 7.41e-09

orphan GPR126 and related proteins, group VIII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Group VIII adhesion GPCRs include orphan GPCRs such as GPR56, GPR64, GPR97, GPR112, GPR114, and GPR126. GPR56 is involved in the regulation of oligodendrocyte development and myelination in the central nervous system via coupling to G(12/13) proteins, which leads to the activation of RhoA GTPase. GPR126, on the other hand, is required for Schwann cells, but not oligodendrocyte myelination in the peripheral nervous system. Gpr64 is mainly expressed in the epididymis of male reproductive tract, and targeted deletion of GPR64 causes sperm stasis and efferent duct blockage due to abnormal fluid reabsorption, resulting in male infertility. GPR64 is also over-expressed in Ewing's sarcoma (ES), as well as upregulated in other carcinomas from kidney, prostate or lung, and promotes invasiveness and metastasis in ES via the upregulation of placental growth factor (PGF) and matrix metalloproteinase (MMP) 1. GPR97 is identified as a lymphatic adhesion receptor that is specifically expressed in lymphatic endothelium, but not in blood vascular endothelium, and is shown to regulate migration of lymphatic endothelial cells via the small GTPases RhoA and cdc42. GPR112 is specifically expressed in normal enterochromatin cells and gastrointestinal neuroendocrine carcinoma cells, but its biological function is unknown. GPR114 is mainly found in granulocytes (polymorphonuclear leukocytes), and GPR114-transfected cells induced an increase in cAMP levels via coupling to G(s) protein. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320386 [Multi-domain]  Cd Length: 267  Bit Score: 58.58  E-value: 7.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  763 CGFITIFLHCAILSGTAWFCYEAFHSYStltsdeLLLEVDQTpKVNCYYL----LSYGLSLSVVAISLVIDPSTYTqndY 838
Cdd:cd15258    70 CIAVAVALHYFLLACLTWMGLEAFHLYL------LLVKVFNT-YIRRYILklclVGWGLPALLVTLVLSVRSDNYG---P 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  839 CVLMEANALFYATF--VIPVLVFFVAAIGY---TFLSWIIM--------CRKSRTGLKTKEHTRLASVRFDIRCSFvfll 905
Cdd:cd15258   140 ITIPNGEGFQNDSFcwIRDPVVFYITVVGYfglTFLFNMVMlatvlvqiCRLREKAQATPRKRALHDLLTLLGLTF---- 215
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 221330065  906 LLSAVWCSAYFYLRGAKMdddtadVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYR 962
Cdd:cd15258   216 LLGLTWGLAFFAWGPFNL------PFLYLFAIFNSLQGFFIFIWYCSMKENVRKQWR 266
7tmB2_BAI1 cd15990
brain-specific angiogenesis inhibitor 1, a group VII adhesion GPCR, member of the class B2 ...
727-966 1.86e-08

brain-specific angiogenesis inhibitor 1, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediates direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320656  Cd Length: 267  Bit Score: 57.31  E-value: 1.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  727 FVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSdelllEVDQTPK 806
Cdd:cd15990    35 YIRSERSVILINFCLSIISSNALILIGQTQTRNKVVCTLVAAFLHFFFLSSFCWVLTEAWQSYMAVTG-----RLRNRII 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  807 VNCYYLLSYGLSLSVVAISL-VIDPSTYTQNDYCVLMEANALFYAtFVIP--VLVFFVAAIGYTFLSWIImcrkSRTGLK 883
Cdd:cd15990   110 RKRFLCLGWGLPALVVAISVgFTKAKGYGTVNYCWLSLEGGLLYA-FVGPaaAVVLVNMVIGILVFNKLV----SKDGIT 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  884 TKEHTRLASVRFDIRCsfVFLLLLSAVWCSAYFylrgaKMDDDTADVYGYCFICFNTLLGLYIFVFHCIqnekIRREYRK 963
Cdd:cd15990   185 DKKLKERAGASLWSSC--VVLPLLALTWMSAVL-----AITDRRSALFQILFAVFDSLEGFVIVMVHCI----LRREVQD 253

                  ...
gi 221330065  964 YVR 966
Cdd:cd15990   254 AVK 256
Gal_Rha_Lectin_CSL1_rpt2 cd22834
second galactose/rhamnose binding lectin domain found in Oncorhynchus keta CSL1 and similar ...
3-45 2.32e-08

second galactose/rhamnose binding lectin domain found in Oncorhynchus keta CSL1 and similar proteins; The family includes a group of L-rhamnose-binding lectins, such as Oncorhynchus keta CSL1. CSL1 has hemagglutinating activity towards rabbit erythrocytes, but not human type B erythrocytes. Its hemagglutinating activity is inhibited by smooth-type lipopolysaccharide (LPS) from Klebsiella pneumoniae, Escherichia coli K-235, Shigella flexneri 1A, Aeromonas salmonicida and Salmonella minnesota and rough-type LPS from S. flexneri, but not by rough-type LPS from E. coli K12 and E. coli EH100. CSL1 agglutinates E. coli K12 and Bacillus subtilis. CSL1 contains two tandem galactose-binding lectin domains. This model corresponds to the second one.


Pssm-ID: 438691 [Multi-domain]  Cd Length: 95  Bit Score: 53.23  E-value: 2.32e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 221330065    3 PKSLSVLNSRCAHKQSCGVLAaTSMFGDPCPGTHKYLEAHYQC 45
Cdd:cd22834    54 PETTKVMSERCNGKSLCDLLA-SNVVTDPCYGTYKYLEVSYSC 95
Gal_Rha_Lectin_CSL3_rpt1_rpt2-like cd22832
first and second galactose/rhamnose binding lectin domain found in Oncorhynchus keta ...
3-45 4.38e-08

first and second galactose/rhamnose binding lectin domain found in Oncorhynchus keta L-rhamnose-binding lectin CSL3 and similar proteins; The family includes a group of L-rhamnose-binding lectins, such as Oncorhynchus keta CSL1-3. CSL1 has hemagglutinating activity towards rabbit erythrocytes, but not human type B erythrocytes. CSL2 has hemagglutinating activity towards rabbit erythrocytes and human type B erythrocytes. CSL3 has hemagglutinating activity towards rabbit erythrocytes, human type A erythrocytes, human type B erythrocytes, human type O erythrocytes, and sheep erythrocytes. Their hemagglutinating activities are inhibited by smooth-type lipopolysaccharide (LPS) from different bacterial species. Members in this family contain two tandem galactose-binding lectin domains. This model corresponds to the first and second galactose/rhamnose-binding lectin domains found in Oncorhynchus keta CSL3, as well as the second galactose/rhamnose-binding lectin domain found in Oncorhynchus keta CSL2.


Pssm-ID: 438689 [Multi-domain]  Cd Length: 94  Bit Score: 52.49  E-value: 4.38e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 221330065    3 PKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQC 45
Cdd:cd22832    52 QSTTSKMAERCDGKSQCIVPASNSVFGDPCVGTYKYLDVAYTC 94
Gal_Rha_Lectin_LPHN2 cd22845
galactose/rhamnose binding lectin domain found in latrophilin-2 and similar proteins; ...
2-46 4.73e-08

galactose/rhamnose binding lectin domain found in latrophilin-2 and similar proteins; Latrophilin-2 (LPHN2), also called adhesion G protein-coupled receptor L2 (ADGRL2), or calcium-independent alpha-latrotoxin receptor 2 (CIRL-2), or latrophilin homolog 1 (LPHH1), or lectomedin-1, is ubiquitously distributed calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. It is probably implicated in the regulation of exocytosis. This model corresponds to a galactose/rhamnose-binding lectin domain found at the N-terminus of LPHN2.


Pssm-ID: 438702 [Multi-domain]  Cd Length: 97  Bit Score: 52.32  E-value: 4.73e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 221330065    2 FPKSLSVLNSRCAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQCI 46
Cdd:cd22845    51 LPDAYKIMTQRCNNRTQCIVVTGSDVFPDPCPGTYKYLEVQYECV 95
7tmB2_BAI2 cd15988
brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 ...
715-966 8.72e-08

brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediates direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320654 [Multi-domain]  Cd Length: 291  Bit Score: 55.73  E-value: 8.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  715 IALLTLKLFNGVF---VKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYST 791
Cdd:cd15988    17 MALLILLAIYAAFwrfIRSERSIILLNFCLSILASNILILVGQSQTLSKGVCTMTAAFLHFFFLSSFCWVLTEAWQSYLA 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  792 LTSDElllevdQTPKVNCYYL-LSYGLSLSVVAISLVIDPST-YTQNDYCVLMEANALFYAtFVIP--VLVFFVAAIGYT 867
Cdd:cd15988    97 VIGRM------RTRLVRKRFLcLGWGLPALVVAVSVGFTRTKgYGTASYCWLSLEGGLLYA-FVGPaaVIVLVNMLIGII 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  868 FLSWIIM-------CRKSRTGLKTKEHTRL--------------------ASVRFDIRCSFVFLLLLSAVWCSAYFylrg 920
Cdd:cd15988   170 VFNKLMSrdgisdkSKKQRAGSEAEPCSSLllkcskcgvvssaamssataSSAMASLWSSCVVLPLLALTWMSAVL---- 245
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 221330065  921 aKMDDDTADVYGYCFICFNTLLGLYIFVFHCIqnekIRREYRKYVR 966
Cdd:cd15988   246 -AMTDRRSILFQVLFAVFNSVQGFVIITVHCF----LRREVQDVVK 286
7tmB2_GPR116-like_Adhesion_VI cd15932
orphan GPR116 and related proteins, group IV adhesion GPCRs, member of the class B2 family of ...
811-959 1.52e-07

orphan GPR116 and related proteins, group IV adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors; group VI adhesion GPCRs consist of orphan receptors GPR110, GPR111, GPR113, GPR115, GPR116, and closely related proteins. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. GPR110 possesses a SEA box in the N-terminal has been identified as an oncogene over-expressed in lung and prostate cancer. GPR113 contains a hormone binding domain and one EGF (epidermal grown factor) domain. GPR112 has extremely long N-terminus (about 2,400 amino acids) containing a number of Ser/Thr-rich glycosylation sites and a pentraxin (PTX) domain. GPR116 has two C2-set immunoglobulin-like repeats, which is found in the members of the immunoglobulin superfamily of cell surface proteins, and a SEA (sea urchin sperm protein, enterokinase, and a grin)-box, which is present in the extracellular domain of the transmembrane mucin (MUC) family and known to enhance O-glycosylation. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320598 [Multi-domain]  Cd Length: 268  Bit Score: 54.63  E-value: 1.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  811 YLLSYG--LSLSVVAISLVIDPSTYTQNDYCVL--MEANALFyaTFVIPVLVffVAAIGYTFLSWII--MCRKSrTGLKT 884
Cdd:cd15932   122 FSLGYGcpLIIAIITVAATAPQGGYTRKGVCWLnwDKTKALL--AFVIPALA--IVVVNFIILIVVIfkLLRPS-VGERP 196
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221330065  885 KEHTRLASVRFdIRCSFVFLLLLSAVWCsayFYLrgAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRR 959
Cdd:cd15932   197 SKDEKNALVQI-GKSVAILTPLLGLTWG---FGL--GTMIDPKSLAFHIIFAILNSFQGFFILVFGTLLDSKVRE 265
Gal_Rha_Lectin_LAT1 cd22839
galactose/rhamnose binding lectin domain found in Caenorhabditis elegans latrophilin-like ...
3-45 1.58e-07

galactose/rhamnose binding lectin domain found in Caenorhabditis elegans latrophilin-like protein 1 (LAT1) and similar proteins; LAT1 plays a role in the establishment of anterior-posterior polarity in tissues during embryogenesis. It is required for the alignment of the mitotic spindles and division planes. It may have a role in cell death events and play an essential role in normal defection and oocyte fertilization. LAT1 is involved in sperm function. it operates in pharyngeal pumping during feeding. LAT1 contains a galactose/rhamnose binding lectin domain at the N-terminus.


Pssm-ID: 438696 [Multi-domain]  Cd Length: 95  Bit Score: 50.88  E-value: 1.58e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 221330065    3 PKSLSVLNSRCAHKQSCGVLAATSMF-GDPCPGTHKYLEAHYQC 45
Cdd:cd22839    52 DKTLPILQKSCDGKSECSFVVSNKFFfEDPCPGTPKYLEATYSC 95
7tmB2_BAI3 cd15989
brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 ...
709-966 4.40e-07

brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors; Brain-specific angiogenesis inhibitors (BAI1-3) constitute the group VII of cell-adhesion receptors that have been implicated in vascularization of glioblastomas. They belong to the B2 subfamily of class B GPCRs, are predominantly expressed in the brain, and are only present in vertebrates. Three BAIs, like all adhesion receptors, are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. For example, BAI1 N-terminus contain an integrin-binding RGD (Arg-Gly-Asp) motif in addition to five thrombospondin type 1 repeats (TSRs), which are known to regulate the anti-angiogenic activity of thrombospondin-1, whereas BAI2 and BAI3 have four TSRs, but do not possess RGD motifs. The TSRs are functionally involved in cell attachment, activation of latent TGF-beta, inhibition of angiogenesis and endothelial cell migration. The TSRs of BAI1 mediates direct binding to phosphatidylserine, which enables both recognition and internalization of apoptotic cells by phagocytes. Thus, BAI1 functions as a phosphatidylserine receptor that forms a trimeric complex with ELMO and Dock180, leading to activation of Rac-GTPase which promotes the binding and phagocytosis of apoptotic cells. BAI3 can also interact with the ELMO-Dock180 complex to activate the Rac pathway and can also bind to secreted C1ql proteins of the C1Q complement family via its N-terminal TSRs. BAI3 and its ligands C1QL1 are highly expressed during synaptogenesis and are involved in synapse specificity. Moreover, BAI2 acts as a transcription repressor to regulate vascular endothelial growth factor (VEGF) expression through interaction with GA-binding protein gamma (GABP). The N-terminal extracellular domains of all three BAIs also contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain, which undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif to generate N- and C-terminal fragments (NTF and CTF), a putative hormone-binding domain (HBD), and multiple N-glycosylation sites. The C-terminus of each BAI subtype ends with a conserved Gln-Thr-Glu-Val (QTEV) motif known to interact with PDZ domain-containing proteins, but only BAI1 possesses a proline-rich region, which may be involved in protein-protein interactions.


Pssm-ID: 320655 [Multi-domain]  Cd Length: 293  Bit Score: 53.53  E-value: 4.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  709 CVVFIVIALLTLKLFNgvFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHS 788
Cdd:cd15989    18 CLALITLAVVYAALWR--YIRSERSIILINFCLSIISSNILILVGQTQTHNKGICTMTTAFLHFFFLASFCWVLTEAWQS 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  789 YSTLTSDELLLEVDQTpkvncYYLLSYGLSLSVVAISLVIDPST-YTQNDYCVLMEANALFYAtFVIP--VLVFFVAAIG 865
Cdd:cd15989    96 YMAVTGKIRTRLIRKR-----FLCLGWGLPALVVAISMGFTKAKgYGTPHYCWLSLEGGLLYA-FVGPaaAVVLVNMVIG 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  866 YTFLSWIIMCR-------KSRTGLKTKEHTRL--------------------ASVRFDIRCSFVFLLLLSAVWCSAYFyl 918
Cdd:cd15989   170 ILVFNKLVSRDgildkklKHRAGQMSEPHSGLtlkcakcgvvsttalsattaSNAMASLWSSCVVLPLLALTWMSAVL-- 247
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 221330065  919 rgaKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYVR 966
Cdd:cd15989   248 ---AMTDKRSILFQILFAVFDSLQGFVIVMVHCILRREVQDAFRCRLR 292
Gal_Rha_Lectin_EVA1_EVA1C_rpt2 cd22829
second galactose/rhamnose binding lectin domain found in Caenorhabditis elegans protein EVA-1, ...
6-47 4.44e-07

second galactose/rhamnose binding lectin domain found in Caenorhabditis elegans protein EVA-1, human protein EVA-1 homolog C and similar proteins; The family includes Caenorhabditis elegans protein EVA-1 and its homologs, such as human protein EVA-1 homolog C (also known as C21orf63). EVA-1 functions as an UNC-40 coreceptor to enhance attraction to the MADD-4 guidance cue in C. elegans. It also acts as a receptor for slt-1 and is required for the guidance of the AVM pioneer axon to the ventral nerve cord. Human C21orf63 is a type-1 transmembrane heparin-binding protein. Members in this family contain two tandem galactose/rhamnose-binding lectin domains. This model corresponds to the second one. Due to the lack of rhamnose-binding key residues, the second galactose/rhamnose-binding domains of EVA-1 does not form a binding pocket for rhamnose.


Pssm-ID: 438686 [Multi-domain]  Cd Length: 99  Bit Score: 49.57  E-value: 4.44e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 221330065    6 LSVLNSRCAHKQSCGVLAATSMFGDPC-PGTHKYLEAHYQCIS 47
Cdd:cd22829    57 LETVMKRCHGKRRCSLTADSETFGDPCpPGVRKYLKVVYTCVP 99
Gal_Rha_Lectin_BGal cd22842
galactose/rhamnose binding lectin domain found in plant beta-galactosidases and similar ...
3-43 1.38e-06

galactose/rhamnose binding lectin domain found in plant beta-galactosidases and similar proteins; The family represents a group of plant beta-galactosidases (BGals), which belong to glycoside hydrolase family 35. They have a C-terminal domain homologous to animal galactose and rhamnose-binding lectins. BGals (EC 3.2.1.23), also called Exo-(1->4)-beta-D-galactanase, or lactase, catalyze hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. Some family members contain more than one galactose/rhamnose binding lectin domain. Due to the lack of rhamnose-binding key residues, the galactose/rhamnose-binding lectin domains of BGals do not form a binding pocket for rhamnose. Therefore, BGals are unlikely to act as rhamnose-binding lectins.


Pssm-ID: 438699 [Multi-domain]  Cd Length: 91  Bit Score: 48.05  E-value: 1.38e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 221330065    3 PKSLSVLNSRCAHKQSCGVLAATSM-FGDPCPGTHKYL--EAHY 43
Cdd:cd22842    48 PNSLSVVEKACLGKNSCSIPASNSVfFGDPCPGTTKRLavQATC 91
7tmB2_GPR128 cd15257
orphan adhesion receptor GPR128, member of the class B2 family of seven-transmembrane G ...
763-963 3.39e-06

orphan adhesion receptor GPR128, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR128 is an orphan receptor of the adhesion family (subclass B2) that belongs to the class B GPCRs. Expression of GPR128 was detected in the mouse intestinal mucosa and is thought to be involved in energy balance, as its knockout mice showed a decrease in body weight gain and an increase in intestinal contraction frequency compared to wild-type controls. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320385 [Multi-domain]  Cd Length: 303  Bit Score: 51.03  E-value: 3.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  763 CGFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPKVNcyyLLSYGLSLSVVAI----------SLVIDPST 832
Cdd:cd15257    93 CTAVAALLHYFLLVTFMWNAVYSAQLYLLLIRMMKPLPEMFILQAS---AIGWGIPAVVVAItlgatyrfptSLPVFTRT 169
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  833 YTQNDYCVL--MEAN-----ALFYAtFVIPVLVFFVAAIGYTFLSWIIMCRKSRTGLKTKEhtrlASVRFDIRCSFVFLL 905
Cdd:cd15257   170 YRQEEFCWLaaLDKNfdikkPLLWG-FLLPVGLILITNVILFIMTSQKVLKKNNKKLTTKK----RSYMKKIYITVSVAV 244
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 221330065  906 LLSAVWCSAYFYLrgaKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRK 963
Cdd:cd15257   245 VFGITWILGYLML---VNNDLSKLVFSYIFCITNTTQGVQIFILYTWRTPEFRKLVSK 299
7tmB2_GPR123 cd16000
G protein-coupled receptor 123, member of the class B2 family of seven-transmembrane G ...
753-957 1.15e-05

G protein-coupled receptor 123, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR123 is an orphan receptor that has been classified as that belongs to the group III of adhesion GPCRs, and also includes orphan receptors GPR124 and GPR125. GPR123 is predominantly expressed in the CNS including thalamus, brain stem and regions containing large pyramidal cells, yet its biological function remains to be determined. Adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320666 [Multi-domain]  Cd Length: 275  Bit Score: 48.80  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  753 GIEQTETSIFCGFITIFLHCAILSGTAWFCYEAFHSYSTLTSD-ELLLEVDQTP----KVNCYYLLSYGLSLSVVAISLV 827
Cdd:cd16000    60 GINRTKYPIICQAVGIVLHYSTLSTMLWIGVTARNIYKQVTKKpHLCQDTDQPPypkqPLLRFYLVSGGVPFIICGITAA 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  828 IDPSTYTQND----YCVLMEANAL--FYATFVIPVLVFFVaaigYTFLSWIIMCRKSRTGLKTK-EHtrlaSVRFDIRCS 900
Cdd:cd16000   140 TNINNYGTEDedtpYCWMAWEPSLgaFYGPVAFIVLVTCI----YFLCTYVQLRRHPERKYELKnEH----SFKAQLRAA 211
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 221330065  901 FVFLLLLSAVWC-SAYFYLRGAKMDDDTADVYGycfiCFNTLLGLYIFVFHCIQNEKI 957
Cdd:cd16000   212 AFTLFLFTATWAfGALAVSQGHFLDMIFSCLYG----AFCVTLGLFILIHHCAKRDDV 265
Gal_Rha_Lectin_CSL1-2_RBL_SML_rpt1 cd22833
first galactose/rhamnose binding lectin domain found in Oncorhynchus keta CSL1-2, Silurus ...
3-46 4.67e-05

first galactose/rhamnose binding lectin domain found in Oncorhynchus keta CSL1-2, Silurus asotus RBL, Scomberomorus niphonius SML and similar proteins; The family includes a group of L-rhamnose-binding lectins, such as Oncorhynchus keta CSL1 and CSL2. CSL1 has hemagglutinating activity towards rabbit erythrocytes, but not human type B erythrocytes. CSL2 has hemagglutinating activity towards rabbit erythrocytes and human type B erythrocytes. Their hemagglutinating activities are inhibited by smooth-type lipopolysaccharide (LPS) from different bacterial species. The family also includes Silurus asotus rhamnose-binding lectin (RBL) and Scomberomorus niphonius L-rhamnose-binding lectin (SML). RBL, also known as Silurus asotus (catfish) roe lectin (SAL), is a lectin that binds L-rhamnose. It also binds monosaccharides possessing steric similarity to the hydroxyl group orientation at C2 and C4 of the pyranose ring structure of L-rhamnose, such as L-mannose and L-lyxose. RBL does not require a Ca2+ ion or free thiol group for its agglutination activity. SML is a rhamnose-binding lectin that also binds melibiose, raffinose, D-galactose, L-arabinose, D-fucose, maltose, and D-glucose with decreasing affinity. It does not bind D-arabinose, L-fucose, lactose, xylose or 2-deoxy-D-galactose. SML shows strong hemagglutinating activity against rabbit erythrocytes. CSL1-2 and SML contain two tandem galactose/rhamnose-binding lectin domains. RBL contains three galactose/rhamnose-binding lectin domains. This model corresponds to the first one.


Pssm-ID: 438690 [Multi-domain]  Cd Length: 97  Bit Score: 43.79  E-value: 4.67e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 221330065    3 PKSLSVLNSRCAHKQSCGVlaATSMFG--DPCPGTHKYLEAHYQCI 46
Cdd:cd22833    53 SGTLDLLKNRCDGKKVCEL--NTNDFRtsDPCPGTYKYLQTNYTCL 96
7tmB2_GPR116_Ig-Hepta cd15254
The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family ...
797-958 1.92e-04

The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR116 (also known as Ig-hepta) is an orphan receptor that belongs to group VI adhesion-GPCRs along with GPR110, GPR111, GPR113, and GPR115. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. GPR116 has four I-set immunoglobulin-like repeats, which is found in the members of the immunoglobulin superfamily of cell surface proteins, and a SEA (sea urchin sperm protein, enterokinase, and a grin)-box, which is present in the extracellular domain of the transmembrane mucin (MUC) family and known to enhance O-glycosylation. GPR116 is highly expressed in fetal and adult lung, and it has been shown to regulate lung surfactant levels as well as to stimulate breast cancer metastasis through a G(q)-p63-RhoGEF-Rho GTPase signaling pathway. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320382 [Multi-domain]  Cd Length: 275  Bit Score: 45.18  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  797 LLLEVDQTPKVNCYYLLSYG--LSLSVVAISLVIDPSTYTQNDYCVLMEANALFYATFVIPVLVffVAAIGyTFLSWIIM 874
Cdd:cd15254   110 ILHDTSKTIQKAVAFCLGYGcpLIISVITIAVTLPRDSYTRKKVCWLNWEDSKALLAFVIPALI--IVAVN-SIITVVVI 186
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  875 CRKSRTGLKTKEHTRLASVRFDIRCSFVFLL-LLSAVWCsayFYLrgAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQ 953
Cdd:cd15254   187 VKILRPSIGEKPSKQERSSLFQIIKSIGVLTpLLGLTWG---FGL--ATVIKGSSIVFHILFTLLNAFQGLFILVFGTLW 261

                  ....*
gi 221330065  954 NEKIR 958
Cdd:cd15254   262 DKKVQ 266
Gal_Rha_Lectin_LAT2 cd22840
galactose/rhamnose binding lectin domain found in Caenorhabditis elegans latrophilin-like ...
3-45 8.22e-04

galactose/rhamnose binding lectin domain found in Caenorhabditis elegans latrophilin-like protein 2 (LAT2) and similar proteins; LAT2 may have a role in pharyngeal pumping during feeding. It contains a galactose/rhamnose binding lectin domain at the N-terminal region. Due to the lack of rhamnose-binding key residues, the galactose/rhamnose-binding domains of LAT2 does not form a binding pocket for rhamnose. Therefore, LAT2 is unlikely to act as a rhamnose-binding lectin.


Pssm-ID: 438697 [Multi-domain]  Cd Length: 96  Bit Score: 40.09  E-value: 8.22e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 221330065    3 PKSLSVLNSRCAHKQSCGVLAATSMF-GDPCPGTH-KYLEAHYQC 45
Cdd:cd22840    52 PNSLQTMRQRCQGRQSCEIRVLNSLFpNDPCPGTSkKYLEYRYRC 96
Herpes_TAF50 pfam03326
Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 ...
1151-1297 1.63e-03

Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.


Pssm-ID: 308764 [Multi-domain]  Cd Length: 568  Bit Score: 43.15  E-value: 1.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  1151 ASSPQQAHEVFYWT--QKPNSGHNGKKKRGAGGVPASPSGSLHSRTAAAS------QVLFYPSYKKTKPGQPTGYPQYAE 1222
Cdd:pfam03326  358 ATAHQESDQRPIGPgpEKPTFLPPVGGKQFFQGLRDSRSTSFLTAPEATSaisdvfQGTEVCQPKRIRALHPPGSPSANR 437
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221330065  1223 ALDPPLA-TGNAAAYYQQQQQLRRQQLHQQQQQQQQQQLSSDEEQAEQHAHLLHLQRRAG--SQQQLPAPPPHMAQYQ 1297
Cdd:pfam03326  438 PLPSSLApTPTGPVHEPGSSLTPATVPQPLDAAPVATPEASHELQPPDEETPQPLDEDQAlcGQQDASHPPPRGQLDE 515
7tmB2_GPR113 cd15253
orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G ...
817-963 1.91e-03

orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR113 is an orphan receptor that belongs to group VI adhesion-GPCRs along with GPR110, GPR111, GPR115, and GPR116. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. GPR113 contains a hormone binding domain and one EGF (epidermal grown factor) domain, and is primarily expressed in a subset of taste receptor cells. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.


Pssm-ID: 320381 [Multi-domain]  Cd Length: 271  Bit Score: 42.05  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  817 LSLSVVAISLVIDPSTYTQNDYCVLMEANALFYaTFVIPVLVFFVAAIGYTFLSWIIMCRKSRT-GLKTKEHTRLASVrf 895
Cdd:cd15253   129 LLIAAATVAYYYPKRQYLHEGACWLNGESGAIY-AFSIPVLAIVLVNLLVLFVVLMKLMRPSVSeGPPPEERKALLSI-- 205
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221330065  896 dircsFVFLLLLSAVWcSAYFYLRGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRK 963
Cdd:cd15253   206 -----FKALLVLTPVF-GLTWGLGVATLTGESSQVSHYGFAILNAFQGVFILLFGCLMDKKVREALLK 267
PLN03059 PLN03059
beta-galactosidase; Provisional
4-45 2.71e-03

beta-galactosidase; Provisional


Pssm-ID: 166698 [Multi-domain]  Cd Length: 840  Bit Score: 42.68  E-value: 2.71e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 221330065    4 KSLSVLNSRCAHKQSCGVLAATSMF-GDPCPGTHKYLEAHYQC 45
Cdd:PLN03059  797 KSYDAFERNCIGKQSCSVTVAPEVFgGDPCPDSMKKLSVEAVC 839
Gal_Rha_Lectin_nemgal cd22838
galactose/rhamnose binding lectin domain found in Hydra vulgaris nematogalectin and similar ...
13-46 2.98e-03

galactose/rhamnose binding lectin domain found in Hydra vulgaris nematogalectin and similar proteins; Nematogalectin, also called nemgal, is a nematocyst protein with an N-terminal GlyXY domain and a galactose/rhamnose binding lectin domain. There are two nematogalectins, A and B, in Hydra, and they are the products of alternative splicing. They are major components of the nematocyst tubule. Nematogalectin functions as a trimer that could bind to multiple chondroitin glycosaminoglycan molecules and stabilize the chondroitin proteoglycan layer.


Pssm-ID: 438695 [Multi-domain]  Cd Length: 100  Bit Score: 38.79  E-value: 2.98e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 221330065   13 CAHKQSCGVLAATSMFGDP-CPGTHKYLEAHYQCI 46
Cdd:cd22838    65 CQGEQACEVVASNIFFDDTiCPDVYKYLKVKYECI 99
Gal_Rha_Lectin_PKD1L2 cd22831
galactose binding lectin domain found in polycystic kidney disease protein 1-like 2 ...
13-46 3.58e-03

galactose binding lectin domain found in polycystic kidney disease protein 1-like 2 (polycystin-1L2) and similar proteins; Polycystin-1L2 is a novel G-protein-coupled receptor that may function as an ion-channel regulator. This model corresponds to a galactose/rhamnose-binding lectin domain found at the N-terminal region of polycystin-1L2. Due to the lack of rhamnose-binding key residues, the galactose/rhamnose-binding domains of Polycystin-1L2 does not form a binding pocket for rhamnose. Therefore, Polycystin-1L2 is unlikely to act as a rhamnose-binding lectin.


Pssm-ID: 438688 [Multi-domain]  Cd Length: 98  Bit Score: 38.49  E-value: 3.58e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 221330065   13 CAHKQSCGVLAATSMFGDPCPGTHKYLEAHYQCI 46
Cdd:cd22831    64 CHGLQVCQIPADPSSFGEPCPELGSYLSVEYHCK 97
7tmB2_GPR124 cd15998
G protein-coupled receptor 124, member of the class B2 family of seven-transmembrane G ...
710-962 6.40e-03

G protein-coupled receptor 124, member of the class B2 family of seven-transmembrane G protein-coupled receptors; GPR124 is an orphan receptor that has been classified as that belongs to the group III of adhesion GPCRs, which also includes orphan GPR123 and GPR125. GPR124, also known as tumor endothelial marker 5 (TEM5), is highly expressed in tumor vessels and in the vasculature of the developing embryo. GPR124 is essentially required for proper angiogenic sprouting into neural tissue, CNS-specific vascularization, and formation of the blood-brain barrier. GPR124 interacts with the PDZ domain of DLG1 (discs large homolog 1) through its PDZ-binding motif. Recently, studies of double-knockout mice showed that GPR124 functions as a co-activator of Wnt7a/Wnt7b-dependent beta-catenin signaling in brain endothelium. Moreover, WNT7-stimulated beta-catenin signaling is regulated by GPR124's intracellular PDZ binding motif and leucine-rich repeats (LRR) in its N-terminal extracellular domain. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, that are coupled to a class B seven-transmembrane domain. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.


Pssm-ID: 320664 [Multi-domain]  Cd Length: 268  Bit Score: 40.32  E-value: 6.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  710 VVFIVIALLTLKLFNGVF--------VKSARTSIYTSIYLC--LLAIELLFLLGIEQTETSIFCGFITIFLHCAILSGTA 779
Cdd:cd15998     7 VVYPCTALLLLCLFSTIItyilnhssIHVSRKGWHMLLNLCfhIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  780 WFCYEAFHSYSTLTSDELLLEVDQ----TPKVNC-YYLLSYGLSLSVVAISLVIDPSTYTQND-YCVLMEANALfyATFV 853
Cdd:cd15998    87 WMGVKARVLHKELTWRAPPPQEGDpalpTPRPMLrFYLIAGGIPLIICGITAAVNIHNYRDHSpYCWLVWRPSL--GAFY 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  854 IPVLVFFVaaigytfLSWI-IMCrksrTGLKTKEHTRLASVRFDIRCSFVFLL----LLSAVW-CSAYFYLRGAKMDDDT 927
Cdd:cd15998   165 IPVALILL-------VTWIyFLC----AGLHLRGPSADGDSVYSPGVQLGALVtthfLYLAMWaCGALAVSQRWLPRVVC 233
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 221330065  928 ADVYGYCficfNTLLGLYIFVFHCIQNEKIRREYR 962
Cdd:cd15998   234 SCLYGVA----ASALGLFVFTHHCARRRDVRASWR 264
7tmF_Frizzled_SMO cd13951
class F frizzled/smoothened family, member of the 7-transmembrane G protein-coupled receptor ...
698-917 8.96e-03

class F frizzled/smoothened family, member of the 7-transmembrane G protein-coupled receptor superfamily; The class F G protein-coupled receptors includes the frizzled (FZD) family of seven-transmembrane proteins consisting of 10 isoforms (FZD1-10) in mammals. The FZDs are activated by the wingless/int-1 (WNT) family of secreted lipoglycoproteins and preferentially couple to stimulatory G proteins of the Gs family, which activate adenylate cyclase, but can also couple to G proteins of the Gi/Gq families. In the WNT/beta-catenin signaling pathway, the WNT ligand binds to FZD and a lipoprotein receptor-related protein (LRP) co-receptor. This leads to the stabilization and translocation of beta-catenin to the nucleus, where it induces the activation of TCF/LEF family transcription factors. The conserved cytoplasmic motif of FZD, Lys-Thr-X-X-X-Trp, is required for activation of the WNT/beta-catenin pathway, and for membrane localization and phosphorylation of Dsh (dishevelled) protein, a key component of the WNT pathway that relays the WNT signals from the activated receptor to downstream effector proteins. Also included in the class F family is the closely related smoothened (SMO), which is a transmembrane G protein-coupled receptor that acts as the transducer of the hedgehog (HH) signaling pathway. SMO is activated by the hedgehog (HH) family of proteins acting on the 12-transmembrane domain receptor patched (PTCH), which constitutively inhibits SMO. Thus, in the absence of HH proteins, PTCH inhibits SMO signaling. On the other hand, binding of HH to the PTCH receptor activates its internalization and degradation, thereby releasing the PTCH inhibition of SMO. This allows SMO to trigger intracellular signaling and the subsequent activation of the Gli family of zinc finger transcriptional factors and induction of HH target gene expression (PTCH, Gli1, cyclin, Bcl-2, etc). The WNT and HH signaling pathways play critical roles in many developmental processes, such as cell-fate determination, cell proliferation, neural patterning, stem cell renewal, tissue homeostasis and repair, and tumorigenesis, among many others.


Pssm-ID: 320089  Cd Length: 314  Bit Score: 39.99  E-value: 8.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  698 MRIFIYISIGICVVFIVIALLTLKLFNGVFVKSARTSIYTSI--------YL-----------ClLAIELLFLLGIEQTE 758
Cdd:cd13951    11 AEIWISAWSALCFLLTLFTLLTFLIDPSRFRYPERPIIFLALcynfyslgYLvrlvvgregiaC-GKDEGKPYLLLVDGS 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  759 TSIFCGFITIFLHCAILSGTAW---FCYEAFHSYSTLTSDELLlevdqTPKVNCYYLLSYGLS--LSVVAISL-VIDPST 832
Cdd:cd13951    90 GNAPCAIVFLLTYYFGMAASIWwviLTLTWFLSAGLKWSSEAI-----EKKSSYFHLVAWGLPavLTIAVLVLrKVDGDE 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330065  833 YTQNDYCVLMEANALfyATFVI-PVLVFFvaAIGYTFL--SWIIMCR-KSRTGLKTKEHTRLasVRFDIR-CSFVFL-LL 906
Cdd:cd13951   165 LTGICFVGNQNLDAL--RGFVLaPLFLYL--ILGTVFLlcGFLSLFRiRSILSNDGKKTDKL--EKLMLRiGIFAVLyTL 238
                         250
                  ....*....|.
gi 221330065  907 LSAVWCSAYFY 917
Cdd:cd13951   239 PALIVIACYFY 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH