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Conserved domains on  [gi|219802098|ref|NP_001137304|]
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paired-like homeodomain transcription factor LEUTX isoform 2 [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10647766)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

CATH:  1.10.10.60
Gene Ontology:  GO:0003677
PubMed:  21557080|26464018|27768937|1357790
SCOP:  4000291

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 1-34 1.91e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


:

Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 51.10  E-value: 1.91e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 219802098     1 MHPSLATMGKLASKLQLDLSVVKIWFKNQRAKWK 34
Cdd:smart00389  24 PYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
 
Name Accession Description Interval E-value
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 1-34 1.91e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 51.10  E-value: 1.91e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 219802098     1 MHPSLATMGKLASKLQLDLSVVKIWFKNQRAKWK 34
Cdd:smart00389  24 PYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homeodomain pfam00046
Homeodomain;
1-34 2.24e-09

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 50.96  E-value: 2.24e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 219802098    1 MHPSLATMGKLASKLQLDLSVVKIWFKNQRAKWK 34
Cdd:pfam00046  23 PYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 1-34 2.76e-09

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 50.70  E-value: 2.76e-09
                         10        20        30
                 ....*....|....*....|....*....|....
gi 219802098   1 MHPSLATMGKLASKLQLDLSVVKIWFKNQRAKWK 34
Cdd:cd00086   23 PYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
2-34 3.54e-03

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 36.26  E-value: 3.54e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 219802098   2 HPSLATMGKLASKLQLDLSVVKIWFKNQRAKWK 34
Cdd:COG5576   75 YPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
 
Name Accession Description Interval E-value
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 1-34 1.91e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 51.10  E-value: 1.91e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 219802098     1 MHPSLATMGKLASKLQLDLSVVKIWFKNQRAKWK 34
Cdd:smart00389  24 PYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homeodomain pfam00046
Homeodomain;
1-34 2.24e-09

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 50.96  E-value: 2.24e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 219802098    1 MHPSLATMGKLASKLQLDLSVVKIWFKNQRAKWK 34
Cdd:pfam00046  23 PYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 1-34 2.76e-09

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 50.70  E-value: 2.76e-09
                         10        20        30
                 ....*....|....*....|....*....|....
gi 219802098   1 MHPSLATMGKLASKLQLDLSVVKIWFKNQRAKWK 34
Cdd:cd00086   23 PYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
2-34 3.54e-03

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 36.26  E-value: 3.54e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 219802098   2 HPSLATMGKLASKLQLDLSVVKIWFKNQRAKWK 34
Cdd:COG5576   75 YPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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