NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|217330632|ref|NP_001136103|]
View 

speedy protein A isoform 2 [Mus musculus]

Protein Classification

Spy1 domain-containing protein( domain architecture ID 10568376)

Spy1 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Spy1 pfam11357
Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which ...
 68-198 3.72e-81

Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27. Spy1 is also known as Ringo protein A.


:

Pssm-ID: 463263  Cd Length: 131  Bit Score: 240.60  E-value: 3.72e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330632   68 QEMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTINEHTRINFFIALYLANTVEEDEEEAKYEIFPWA 147
Cdd:pfam11357   1 EEMEAFFRLLEDPVIQDFLAWDKCLRVSDKYLLAMVFAYFKRAGLFSWEYTRINFFLALYLANDMEEDEEEPKYEIFPWA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 217330632  148 LGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRER 198
Cdd:pfam11357  81 LGENWRDQYPLFLKLRDQLWARMGYRAAVSRECCEEIMAIDPEHWVWQRDR 131
 
Name Accession Description Interval E-value
Spy1 pfam11357
Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which ...
 68-198 3.72e-81

Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27. Spy1 is also known as Ringo protein A.


Pssm-ID: 463263  Cd Length: 131  Bit Score: 240.60  E-value: 3.72e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330632   68 QEMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTINEHTRINFFIALYLANTVEEDEEEAKYEIFPWA 147
Cdd:pfam11357   1 EEMEAFFRLLEDPVIQDFLAWDKCLRVSDKYLLAMVFAYFKRAGLFSWEYTRINFFLALYLANDMEEDEEEPKYEIFPWA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 217330632  148 LGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRER 198
Cdd:pfam11357  81 LGENWRDQYPLFLKLRDQLWARMGYRAAVSRECCEEIMAIDPEHWVWQRDR 131
 
Name Accession Description Interval E-value
Spy1 pfam11357
Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which ...
 68-198 3.72e-81

Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27. Spy1 is also known as Ringo protein A.


Pssm-ID: 463263  Cd Length: 131  Bit Score: 240.60  E-value: 3.72e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330632   68 QEMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTINEHTRINFFIALYLANTVEEDEEEAKYEIFPWA 147
Cdd:pfam11357   1 EEMEAFFRLLEDPVIQDFLAWDKCLRVSDKYLLAMVFAYFKRAGLFSWEYTRINFFLALYLANDMEEDEEEPKYEIFPWA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 217330632  148 LGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRER 198
Cdd:pfam11357  81 LGENWRDQYPLFLKLRDQLWARMGYRAAVSRECCEEIMAIDPEHWVWQRDR 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH